chr7:87509329:A>G Detail (hg38) (ABCB1)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr7:87,138,645-87,138,645 View the variant detail on this assembly version. |
| hg38 | chr7:87,509,329-87,509,329 |
HGVS
| Type | Transcript | Protein |
|---|---|---|
| RefSeq | NM_000927.4:c.3435T>C | NP_000918.2:p.Ile1145= |
| Ensemble | ENST00000265724.8:c.3435T>C | ENST00000265724.8:p.Ile1145= |
| ENST00000543898.5:c.3243T>C | ENST00000543898.5:p.Ile1081= |
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
Frequency
| JP | HGVD:0.600 |
| ToMMo:0.582 | |
| NCBN:[No Data.] | |
| NCBN(Hondo):[No Data.] | |
| NCBN(Ryukyu):[No Data.] | |
| East asia | ExAC:0.625 |
Prediction
ClinVar
| Clinical Significance |
Benign
Likely benign
|
| Review star |  |
| Show details | |
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
| Clinical significance | Last evaluated | Review status | Condition | Origin | Links |
|---|---|---|---|---|---|
|
Benign
|
2007-01-26 | no assertion criteria provided | MDR1 POLYMORPHISM |
germline
|
Detail |
not provided
|
2016-03-10 | no assertion provided | Non-small cell lung carcinoma |
somatic
|
Detail |
|
Benign
|
2018-03-13 | criteria provided, single submitter | not provided |
germline
|
Detail |
drug response
|
2018-04-28 | no assertion criteria provided |
somatic
|
Detail | |
|
Likely benign
|
2021-07-21 | criteria provided, single submitter | ABCB1-related disorder |
germline
|
Detail |
CIViC
| Disease | Drug | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| breast cancer | B |
Prognostic
|
Supports
|
Better Outcome | Common Germline | 3 | 22906996 | Detail | |
| lung non-small cell carcinoma | Cisplatin,Carboplatin | B |
Predictive
|
Supports
|
Sensitivity/Response | Common Germline | 2 | 22296372 | Detail |
DisGeNET
| Score | Disease name | Description | Source | Pubmed | Links |
|---|---|---|---|---|---|
| <0.001 | diarrhea | In irinotecan-treated patients, T allele of ABCB1C1236T SNP was associated with ... | BeFree | 23543295 | Detail |
| 0.097 | Malignant neoplasm of breast | Polymorphism C3435T of the MDR-1 gene predict response to preoperative chemother... | BeFree | 19151448 | Detail |
| 0.139 | Colorectal Neoplasms | Functional MDR1 polymorphisms (G2677T and C3435T) and TCF4 mutations in colorect... | BeFree | 11980438 | Detail |
| 0.127 | Non-small cell lung carcinoma | MDR1 single nucleotide polymorphism C3435T in Turkish patients with non-small-ce... | BeFree | 22766400 | Detail |
| 0.003 | nephrotic syndrome | Our data suggested that MDR1 C3435T or G2677T/A gene polymorphisms are risk fact... | BeFree | 23994685 | Detail |
| 0.083 | HIV Infections | Prevalence of MDR1 C3435T and CYP2B6 G516T polymorphisms among HIV-1 infected So... | BeFree | 22297601 | Detail |
| 0.008 | chronic lymphocytic leukemia | Different frequencies and effects of ABCB1 T3435C polymorphism on clinical and l... | BeFree | 25586345 | Detail |
| 0.160 | Precursor Cell Lymphoblastic Leukemia Lymphoma | Analysis of single nucleotide polymorphism C3435T of the multidrug resistance ge... | BeFree | 12851703 | Detail |
| 0.004 | Leukemia, Lymphocytic, Acute, L1 | To determine the influence of the MDR1 C3435T polymorphism on the development of... | BeFree | 19317599 | Detail |
| 0.006 | Malignant neoplasm of ovary | CYP2C8*3 and the ABCB1 SNPs C1236T, G2677T/A, and C3435T were not statistically ... | BeFree | 21327421 | Detail |
| 0.011 | colorectal carcinoma | Association between the C3435T polymorphism of ABCB1/MDR1 gene (rs1045642) and c... | BeFree | 23504525 | Detail |
| 0.042 | breast carcinoma | We aimed to determine the associations of genetic polymorphisms of excision repa... | BeFree | 24933103 | Detail |
| 0.009 | Carcinoma of lung | In regard to the clinical implications of MDR1 SNPs, it was found in large meta-... | BeFree | 24687344 | Detail |
| 0.002 | Acute coronary syndrome | The C3435T polymorphism of the MDR-1 gene influences ADP dependent platelet reac... | BeFree | 19784880 | Detail |
| 0.005 | Non-small cell lung carcinoma | We aimed to determine the associations of genetic polymorphisms of excision repa... | BeFree | 24933103 | Detail |
| 0.009 | Acute coronary syndrome | Thus, detection of ABCB1 C3435T polymorphism may be a promising biomarker for th... | BeFree | 25118983 | Detail |
| 0.004 | Leukemia, Lymphocytic, Acute, L1 | MDR1 C3435T and C1236T polymorphisms: association with high-risk childhood acute... | BeFree | 25854371 | Detail |
| 0.097 | Malignant neoplasm of breast | MDR1 C3435T polymorphism in patients with breast cancer. | BeFree | 17560460 | Detail |
| <0.001 | Sickle Cell Dactylitis | The risk for mucosal inflammation was increased in the presence of the G allele ... | BeFree | 19667267 | Detail |
| 0.007 | familial Mediterranean fever | Analysis of common MDR1 (ABCB1) gene C1236T and C3435T polymorphisms in Turkish ... | BeFree | 22194207 | Detail |
| <0.001 | Malignant neoplasm of endometrium | The significance of C3435T point mutation of the MDR1 gene in endometrial cancer... | BeFree | 17300681 | Detail |
| 0.009 | Mental Depression | Implication of P-glycoprotein in formation of depression-prone personality: asso... | BeFree | 24577069 | Detail |
| 0.001 | diarrhea | PG analysis showed that ABCB1 (C3435T)T/T (membrane transport) was associated wi... | BeFree | 19349543 | Detail |
| 0.001 | vascular disease occlusive | All subjects were genotyped for 13 polymorphic variants in the genes of xenobiot... | BeFree | 23107763 | Detail |
| 0.147 | neutropenia | PG analysis showed that ABCB1 (C3435T)T/T (membrane transport) was associated wi... | BeFree | 19349543 | Detail |
| <0.001 | Juvenile arthritis | ABCB1 rs1045642, ABCC3 rs4793665, and SLC19A1 rs1051266 polymorphisms were assoc... | BeFree | 22859359 | Detail |
| 0.121 | COLCHICINE RESISTANCE | Our results indicate that C3435T polymorphism in exon 26 of MDR1 gene is associa... | BeFree | 21851199 | Detail |
| 0.134 | rheumatoid arthritis | These data suggest that the presence of the MTHFR C677T and ABCB1 C3435T SNPs co... | BeFree | 23095111 | Detail |
| 0.012 | Non-small cell lung carcinoma | We aimed to determine the associations of genetic polymorphisms of excision repa... | BeFree | 24933103 | Detail |
| 0.003 | Epilepsy, Generalized | The influence of C3435T polymorphism of ABCB1 gene on penetration of phenobarbit... | BeFree | 18329296 | Detail |
| 0.097 | Malignant neoplasm of breast | The available evidence indicates that MDR1 C3435T polymorphism cannot be conside... | BeFree | 22160574 | Detail |
| 0.002 | Xeroderma Pigmentosum, Complementation Group D | We aimed to determine the associations of genetic polymorphisms of excision repa... | BeFree | 24933103 | Detail |
| 0.011 | stomach carcinoma | No correlation was observed between the C3435T polymorphism of the MDR1 gene and... | BeFree | 22641402 | Detail |
| 0.121 | Esophageal Neoplasms | Impact of ABCB1 C3435T polymorphism on lymph node regression in multimodality tr... | BeFree | 21332314 | Detail |
| 0.004 | Leukemia, Lymphocytic, Acute, L1 | MDR1 C3435T polymorphism and childhood acute lymphoblastic leukemia susceptibili... | BeFree | 25661341 | Detail |
| 0.003 | Diabetes Mellitus, Non-Insulin-Dependent | ) to standard-dose clopidogrel (75 mg/d) (TRIPLE) compared with double-dose clop... | BeFree | 22837373 | Detail |
| 0.042 | breast carcinoma | The distribution of TSER (TYMS), C677T (MTHFR), Arg72Pro (p53) and C3435T (MDR1)... | BeFree | 20371218 | Detail |
| 0.083 | HIV Infections | We studied the influence of AIDS restriction genes (ARGs) CCR5-Delta32, CCR2-64I... | BeFree | 18391751 | Detail |
| 0.097 | Malignant neoplasm of breast | Correlation of polymorphism C3435T of the MDR-1 gene and the response of primary... | BeFree | 18393221 | Detail |
| 0.130 | neutropenia | PG analysis showed that ABCB1 (C3435T)T/T (membrane transport) was associated wi... | BeFree | 19349543 | Detail |
| 0.042 | breast carcinoma | Polymorphism C3435T of the MDR-1 gene predicts response to preoperative chemothe... | BeFree | 12684679 | Detail |
| <0.001 | Adenocarcinoma of large intestine | In this study, 3 genotypes of MDR1, 4 genotypes of MRP1, and 6 genotypes of MRP2... | BeFree | 16107775 | Detail |
| 0.003 | epilepsy | The study failed to corroborate association between polymorphism CYP3A5*3 and C3... | BeFree | 23984379 | Detail |
| 0.011 | stomach carcinoma | MDR1 C3435T polymorphism has no influence on developing Helicobacter pylori infe... | BeFree | 18644389 | Detail |
| 0.009 | Peptic Ulcer | MDR1 C3435T polymorphism has no influence on developing Helicobacter pylori infe... | BeFree | 18644389 | Detail |
| 0.003 | kidney failure | The purpose of this study is to compare the genotype frequency of C3435T and G11... | BeFree | 17376299 | Detail |
| 0.002 | renal carcinoma | In summary, this meta-analysis suggests that the MDR1 C3435T polymorphism is ass... | BeFree | 22358302 | Detail |
| 0.026 | Crohn Disease | A total of 211 patients with Crohn's disease (CD), 97 patients with ulcerative c... | BeFree | 17260353 | Detail |
| <0.001 | Pancolitis | The MDR1 variant C3435T was associated with disease behavior in CD (OR = 1.45, 9... | BeFree | 19685447 | Detail |
| <0.001 | juvenile rheumatoid arthritis | ABCB1 rs1045642, ABCC3 rs4793665, and SLC19A1 rs1051266 polymorphisms were assoc... | BeFree | 22859359 | Detail |
| 0.089 | Epilepsy, Temporal Lobe | Polymorphism of the multidrug resistance 1 gene MDR1/ABCB1 C3435T and response t... | BeFree | 25458099 | Detail |
| 0.080 | breast carcinoma | Polymorphism C3435T of the MDR-1 gene predict response to preoperative chemother... | BeFree | 19151448 | Detail |
| 0.160 | Precursor Cell Lymphoblastic Leukemia Lymphoma | Is the MDR1 C3435T polymorphism responsible for oral mucositis in children with ... | BeFree | 23244145 | Detail |
| 0.098 | Malignant neoplasm of breast | We aimed to determine the associations of genetic polymorphisms of excision repa... | BeFree | 24933103 | Detail |
| 0.002 | Adult Acute Myeloblastic Leukemia | MDR1 C3435T polymorphism influences the development of colon cancer and adult ac... | BeFree | 18644389 | Detail |
| <0.001 | Colorectal cancer metastatic | The aim of the study was to evaluate the influence of the MDR1 C3435T polymorphi... | BeFree | 19862647 | Detail |
| 0.002 | Colorectal Neoplasms | Functional MDR1 polymorphisms (G2677T and C3435T) and TCF4 mutations in colorect... | BeFree | 11980438 | Detail |
| 0.086 | HIV Infections | Prevalence of MDR1 C3435T and CYP2B6 G516T polymorphisms among HIV-1 infected So... | BeFree | 22297601 | Detail |
| <0.001 | sexual dysfunction | This study measured functionally implicated ABCB1 variants (rs2235015, rs1128503... | BeFree | 23356581 | Detail |
| 0.010 | Acute lymphocytic leukemia | MDR1 C3435T polymorphism in Mexican children with acute lymphoblastic leukemia a... | BeFree | 19317599 | Detail |
| 0.083 | HIV Infections | The aim of this study was to investigate the influence of CYP3A5 A6986G, ABCB1 (... | BeFree | 21743379 | Detail |
| 0.018 | Diabetes Mellitus, Non-Insulin-Dependent | ) to standard-dose clopidogrel (75 mg/d) (TRIPLE) compared with double-dose clop... | BeFree | 22837373 | Detail |
| 0.065 | HIV Infections | We studied the influence of AIDS restriction genes (ARGs) CCR5-Delta32, CCR2-64I... | BeFree | 18391751 | Detail |
| 0.015 | Malignant neoplasm of stomach | Lack of association of the MDR1 C3435T polymorphism with susceptibility to gastr... | BeFree | 24815441 | Detail |
| 0.006 | leukopenia | PG analysis showed that ABCB1 (C3435T)T/T (membrane transport) was associated wi... | BeFree | 19349543 | Detail |
| 0.194 | epilepsy | The drug-transporter gene MDR1 C3435T and G2677T/A polymorphisms and the risk of... | BeFree | 24213830 | Detail |
| 0.041 | Malignant neoplasm of lung | In regard to the clinical implications of MDR1 SNPs, it was found in large meta-... | BeFree | 24687344 | Detail |
| 0.013 | colon carcinoma | MDR1 C3435T polymorphism influences the development of colon cancer and adult ac... | BeFree | 18644389 | Detail |
| 0.012 | Hypercholesterolemia | [In conclusion, ABCB1 and ABCC1 mRNA levels in PBMC are modulated by atorvastati... | GAD | 18851956 | Detail |
| 0.194 | epilepsy | All the case-control association researches evaluating the role of MDR1 C3435T p... | BeFree | 24553780 | Detail |
| 0.007 | Helicobacter pylori infection | Effect of MDR1 C3435T polymorphism on cure rates of Helicobacter pylori infectio... | BeFree | 17697203 | Detail |
| 0.010 | Glioma | The C3435T polymorphism of MDR1 and susceptibility to adult glioma. | BeFree | 15947495 | Detail |
| 0.003 | Carcinogenesis | The C3435T (rs1045642) polymorphism, located in multi-drug resistance gene 1 (MD... | BeFree | 24070710 | Detail |
| 0.337 | hyperhomocysteinemia | All subjects were genotyped for 13 polymorphic variants in the genes of xenobiot... | BeFree | 23107763 | Detail |
| 0.080 | breast carcinoma | We aimed to determine the associations of genetic polymorphisms of excision repa... | BeFree | 24933103 | Detail |
| 0.008 | Malignant tumor of colon | Genetic testing for C3435T MDR1 gene polymorphism may be a suitable test to eval... | BeFree | 15912392 | Detail |
| 0.204 | rheumatoid arthritis | These data suggest that the presence of the MTHFR C677T and ABCB1 C3435T SNPs co... | BeFree | 23095111 | Detail |
| 0.008 | acute leukemia | Association of an MDR1 gene (C3435T) polymorphism with acute leukemia in India. | BeFree | 21133625 | Detail |
| 0.001 | diarrhea | In irinotecan-treated patients, T allele of ABCB1C1236T SNP was associated with ... | BeFree | 23543295 | Detail |
| 0.133 | Colorectal Neoplasms | Functional MDR1 polymorphisms (G2677T and C3435T) and TCF4 mutations in colorect... | BeFree | 11980438 | Detail |
| <0.001 | Epithelioma | Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the... | BeFree | 12089380 | Detail |
| 0.194 | epilepsy | The aim of our study was to investigate the relationship between C3435T polymorp... | BeFree | 25223475 | Detail |
| 0.015 | Malignant neoplasm of stomach | MDR1 gene C3435T polymorphism is associated with clinical outcomes in gastric ca... | BeFree | 22296392 | Detail |
| 0.194 | epilepsy | ABCB1 C3435T polymorphism and the risk of resistance to antiepileptic drugs in e... | BeFree | 20605481 | Detail |
| 0.005 | gastritis | We assessed the MDR1 C3435T polymorphism in H. pylori-positive gastritis alone p... | BeFree | 18644389 | Detail |
| 0.022 | Inflammatory Bowel Diseases | MDR1 C3435T polymorphism and inflammatory bowel disease risk: a meta-analysis. | BeFree | 24449364 | Detail |
| 0.003 | Diabetes Mellitus, Non-Insulin-Dependent | ) to standard-dose clopidogrel (75 mg/d) (TRIPLE) compared with double-dose clop... | BeFree | 22837373 | Detail |
| 0.160 | Precursor Cell Lymphoblastic Leukemia Lymphoma | MDR1 C3435T polymorphism in Mexican children with acute lymphoblastic leukemia a... | BeFree | 19317599 | Detail |
| 0.001 | Adenocarcinoma of large intestine | In this study, 3 genotypes of MDR1, 4 genotypes of MRP1, and 6 genotypes of MRP2... | BeFree | 16107775 | Detail |
| 0.010 | Acute lymphocytic leukemia | Is the MDR1 C3435T polymorphism responsible for oral mucositis in children with ... | BeFree | 23244145 | Detail |
| 0.032 | multiple myeloma | [ABCB1 (MDR1) rs1045642 is associated with increased overall survival in plasma ... | GAD | 19373654 | Detail |
| 0.006 | leukopenia | CYP2C8*3 and the ABCB1 SNPs C1236T, G2677T/A, and C3435T were not statistically ... | BeFree | 21327421 | Detail |
| 0.194 | epilepsy | Association of ABCB1 C3435T polymorphism with phenobarbital resistance in Thai p... | BeFree | 25846690 | Detail |
| 0.097 | Malignant neoplasm of breast | The distribution of TSER (TYMS), C677T (MTHFR), Arg72Pro (p53) and C3435T (MDR1)... | BeFree | 20371218 | Detail |
| <0.001 | Hodgkin Disease | these results suggest that MDR1 C3435T polymorphism might play a role in HL occu... | BeFree | 21762523 | Detail |
| 0.164 | Seizures | Role of MDR1 C3435T and GABRG2 C588T gene polymorphisms in seizure occurrence an... | BeFree | 22239287 | Detail |
| 0.016 | myocardial infarction | Thus, detection of ABCB1 C3435T polymorphism may be a promising biomarker for th... | BeFree | 25118983 | Detail |
| 0.055 | leukemia | Association between the MDR1 gene variant C3435T and risk of leukaemia: a meta-a... | BeFree | 23731124 | Detail |
| 0.016 | myocardial infarction | Variant genotypes of APOAI -2500C/T, CETP 405I/V, and ABCB1 3435C/T showed highe... | BeFree | 20578904 | Detail |
| 0.007 | Helicobacter pylori infection | MDR1 C3435T polymorphism has no influence on developing Helicobacter pylori infe... | BeFree | 18644389 | Detail |
| 0.016 | diarrhea | PG analysis showed that ABCB1 (C3435T)T/T (membrane transport) was associated wi... | BeFree | 19349543 | Detail |
| 0.003 | HIV Infections | We investigated whether polymorphisms in MDR1 (T-129C, C1236T and C3435T) and PX... | BeFree | 23528223 | Detail |
| 0.015 | ovarian carcinoma | Basal expression of the multidrug resistance gene 1 (MDR-1) is associated with t... | BeFree | 12142082 | Detail |
| 0.011 | stomach carcinoma | MDR1 gene C3435T polymorphism is associated with clinical outcomes in gastric ca... | BeFree | 22296392 | Detail |
| 0.194 | epilepsy | We included all published studies until September 2007, in which patients with r... | BeFree | 19178561 | Detail |
| 0.006 | Epithelial ovarian cancer | Our study represents the largest analysis of ABCB1 SNPs and EOC progression and ... | BeFree | 23917080 | Detail |
| 0.001 | Coronary heart disease | The C3435T polymorphism in the ABCB1 gene of fetus increases the risks of CHD in... | BeFree | 23874772 | Detail |
| 0.018 | Malignant neoplasm of breast | We aimed to determine the associations of genetic polymorphisms of excision repa... | BeFree | 24933103 | Detail |
| 0.006 | Pain | Single-nucleotide polymorphisms in OPRM1 gene (opioid receptor, A118G), ABCB1 ge... | BeFree | 25576257 | Detail |
| 0.005 | Non-small cell lung carcinoma | We aimed to determine the associations of genetic polymorphisms of excision repa... | BeFree | 24933103 | Detail |
| 0.008 | Malignant tumor of colon | MDR1 C3435T polymorphism influences the development of colon cancer and adult ac... | BeFree | 18644389 | Detail |
| 0.038 | Acute coronary syndrome | Genetic polymorphisms of CYP2C19 2 and ABCB1 C3435T affect the pharmacokinetic a... | BeFree | 25542807 | Detail |
| 0.006 | Malignant neoplasm of kidney | In summary, this meta-analysis suggests that the MDR1 C3435T polymorphism is ass... | BeFree | 22358302 | Detail |
| 0.122 | diffuse large B-cell lymphoma | The present study evaluated the impact of single gene polymorphisms (SNPs: rs180... | BeFree | 23829278 | Detail |
| 0.080 | Colorectal cancer metastatic | The aim of the study was to evaluate the influence of the MDR1 C3435T polymorphi... | BeFree | 19862647 | Detail |
| 0.016 | Alzheimer's disease | ABCB1 C3435T polymorphism influences the risk for Alzheimer's disease. | BeFree | 25273678 | Detail |
| 0.102 | Pain | Single-nucleotide polymorphisms in OPRM1 gene (opioid receptor, A118G), ABCB1 ge... | BeFree | 25576257 | Detail |
| <0.001 | Asthenia | In irinotecan-treated patients, T allele of ABCB1C1236T SNP was associated with ... | BeFree | 23543295 | Detail |
| <0.001 | Asthenia | In irinotecan-treated patients, T allele of ABCB1C1236T SNP was associated with ... | BeFree | 23543295 | Detail |
| <0.001 | Adenocarcinoma of large intestine | In this study, 3 genotypes of MDR1, 4 genotypes of MRP1, and 6 genotypes of MRP2... | BeFree | 16107775 | Detail |
| <0.001 | Adenocarcinoma of large intestine | In this study, 3 genotypes of MDR1, 4 genotypes of MRP1, and 6 genotypes of MRP2... | BeFree | 16107775 | Detail |
| 0.011 | colorectal carcinoma | MDR1 single nucleotide polymorphism C3435T in normal colorectal tissue and color... | BeFree | 12894567 | Detail |
| 0.194 | epilepsy | This study failed to corroborate a previously reported association between the C... | BeFree | 15857428 | Detail |
| <0.001 | uterine corpus cancer | The significance of C3435T point mutation of the MDR1 gene in endometrial cancer... | BeFree | 17300681 | Detail |
| 0.001 | Chronic pain | Polymorphisms of OPRM1 A118G and ABCB1 C3435T have been suggested to contribute ... | BeFree | 23803057 | Detail |
| 0.121 | Pain, Postoperative | Single-nucleotide polymorphism C3435T in the ABCB1 gene is associated with opioi... | BeFree | 24034787 | Detail |
| 0.194 | epilepsy | Significance of MDR1 gene polymorphism C3435T in predicting drug response in epi... | BeFree | 24300029 | Detail |
| <0.001 | ovarian carcinoma | CYP2C8*3 and the ABCB1 SNPs C1236T, G2677T/A, and C3435T were not statistically ... | BeFree | 21327421 | Detail |
| 0.009 | Peptic Ulcer | Lack of association of the MDR1 C3435T polymorphism with susceptibility to gastr... | BeFree | 24815441 | Detail |
| <0.001 | Heart Septal Defects | The C3435T polymorphism in the ABCB1 gene of fetus increases the risks of CHD in... | BeFree | 23874772 | Detail |
| <0.001 | Palmar-plantar erythrodysesthesia syndrome | The risk for mucosal inflammation was increased in the presence of the G allele ... | BeFree | 19667267 | Detail |
| 0.020 | Myeloid Leukemia, Chronic | Three ABCB1 SNPs (C1236T, G2677T, and C3435T) were genotyped in 100 Egyptian pat... | BeFree | 25301112 | Detail |
| 0.194 | epilepsy | Role of MDR1 C3435T and GABRG2 C588T gene polymorphisms in seizure occurrence an... | BeFree | 22239287 | Detail |
| 0.015 | Malignant neoplasm of stomach | No correlation was observed between the C3435T polymorphism of the MDR1 gene and... | BeFree | 22641402 | Detail |
| 0.083 | HIV Infections | We show that genotyping for ABCB1 variations (rs1045642 and rs2032582) may help ... | BeFree | 23372834 | Detail |
| 0.011 | stomach carcinoma | Lack of association of the MDR1 C3435T polymorphism with susceptibility to gastr... | BeFree | 24815441 | Detail |
| 0.042 | breast carcinoma | Effect of ABCB1 C3435T polymorphism on docetaxel pharmacokinetics according to m... | BeFree | 20628376 | Detail |
| <0.001 | leukopenia | CYP2C8*3 and the ABCB1 SNPs C1236T, G2677T/A, and C3435T were not statistically ... | BeFree | 21327421 | Detail |
| <0.001 | hyperhomocysteinemia | All subjects were genotyped for 13 polymorphic variants in the genes of xenobiot... | BeFree | 23107763 | Detail |
| 0.001 | Cancer pain | Gene polymorphisms of OPRM1 A118G and ABCB1 C3435T may influence opioid requirem... | BeFree | 23803057 | Detail |
| <0.001 | Epilepsies, Partial | Polymorphism of ABCB1/MDR1 C3435T in children and adolescents with partial epile... | BeFree | 25223475 | Detail |
| 0.054 | ulcerative colitis | A total of 211 patients with Crohn's disease (CD), 97 patients with ulcerative c... | BeFree | 17260353 | Detail |
| 0.054 | ulcerative colitis | MDR1 C3435T polymorphism is predictive of later onset of ulcerative colitis in J... | BeFree | 16462040 | Detail |
| 0.042 | breast carcinoma | Association of C3435T single-nucleotide polymorphism of MDR1 gene with breast ca... | BeFree | 19388849 | Detail |
| 0.026 | Crohn Disease | The present study examined the association of ABCB1 C3435T and G2677T/A in a lar... | BeFree | 16633048 | Detail |
| 0.084 | Malignant neoplasm of breast | We aimed to determine the associations of genetic polymorphisms of excision repa... | BeFree | 24933103 | Detail |
| 0.042 | breast carcinoma | MDR1 C3435T polymorphism in Mexican patients with breast cancer. | BeFree | 25062490 | Detail |
| 0.003 | endometrial carcinoma | The significance of C3435T point mutation of the MDR1 gene in endometrial cancer... | BeFree | 17300681 | Detail |
| 0.194 | epilepsy | Association of MDR1 (C3435T) polymorphism and resistance to carbamazepine in epi... | BeFree | 17917461 | Detail |
| 0.194 | epilepsy | Lack of association between C3435T nucleotide MDR1 genetic polymorphism and mult... | BeFree | 16542858 | Detail |
| 0.009 | Peptic Ulcer | C3435T polymorphism of the ABCB1 gene: impact on genetic susceptibility to pepti... | BeFree | 22001987 | Detail |
| 0.006 | major depressive disorder | Association between the functional polymorphism (C3435T) of the gene encoding P-... | BeFree | 22306099 | Detail |
| 0.130 | neutropenia | CYP2C8*3 and the ABCB1 SNPs C1236T, G2677T/A, and C3435T were not statistically ... | BeFree | 21327421 | Detail |
| 0.004 | Drug Resistant Epilepsy | Association between MDR1 C3435T polymorphism and refractory epilepsy in the Chin... | BeFree | 24953225 | Detail |
| 0.007 | familial Mediterranean fever | Association analysis of three ABCB1 (MDR1) gene variants (C1236T, G2677A/T and C... | BeFree | 24773260 | Detail |
| 0.045 | colorectal cancer | Association between the C3435T polymorphism of ABCB1/MDR1 gene (rs1045642) and c... | BeFree | 23504525 | Detail |
| 0.006 | Unipolar Depression | Association between the functional polymorphism (C3435T) of the gene encoding P-... | BeFree | 22306099 | Detail |
| <0.001 | Coronary Arteriosclerosis | ABCB1 C3435T polymorphism and the risk of coronary heart disease: a meta-analysi... | BeFree | 24328528 | Detail |
| 0.018 | breast carcinoma | We aimed to determine the associations of genetic polymorphisms of excision repa... | BeFree | 24933103 | Detail |
| 0.008 | chronic lymphocytic leukemia | MDR-1 polymorphisms (G2677T and C3435T) in B-chronic lymphocytic leukemia: an im... | BeFree | 20496015 | Detail |
| 0.083 | HIV Infections | Influence of ABCB-1 C3435T polymorphisms on plasma nevirapine and efavirenz leve... | BeFree | 23082557 | Detail |
| <0.001 | Behcet Syndrome | MDR1 C3435T polymorphism associated with the development of clinical features in... | BeFree | 24898446 | Detail |
| <0.001 | schizoaffective disorder | The present study does not suggest a major influence of MDR1 G2677T/A and C3435T... | BeFree | 20060871 | Detail |
| 0.164 | Seizures | The association of ABCB1-C3435T with risk of drug-resistance was significant in ... | BeFree | 24794827 | Detail |
| 0.026 | Crohn Disease | This was a case-control analysis of MDR1 C3435T and G2677T SNPs in a large well-... | BeFree | 15685540 | Detail |
| 0.006 | leukopenia | In addition, a statistically significant association was found among neutropenia... | BeFree | 25007187 | Detail |
| 0.054 | ulcerative colitis | In regard to the clinical implications of MDR1 SNPs, it was found in large meta-... | BeFree | 24687344 | Detail |
| 0.026 | HIV Infections | The aim of this study was to investigate the influence of CYP3A5 A6986G, ABCB1 (... | BeFree | 21743379 | Detail |
| 0.143 | liver carcinoma | Evaluation of the C3435T polymorphism in the MDR1 gene in patients with hepatoce... | BeFree | 23109454 | Detail |
| 0.042 | breast carcinoma | The available evidence indicates that MDR1 C3435T polymorphism cannot be conside... | BeFree | 22160574 | Detail |
| 0.134 | rheumatoid arthritis | ABCB1 C3435T polymorphism influences methotrexate sensitivity in rheumatoid arth... | BeFree | 17181924 | Detail |
| 0.011 | breast carcinoma | We aimed to determine the associations of genetic polymorphisms of excision repa... | BeFree | 24933103 | Detail |
| 0.001 | Coronary heart disease | ABCB1 C3435T polymorphism and the risk of coronary heart disease: a meta-analysi... | BeFree | 24328528 | Detail |
| 0.001 | Diabetes Mellitus, Non-Insulin-Dependent | ) to standard-dose clopidogrel (75 mg/d) (TRIPLE) compared with double-dose clop... | BeFree | 22837373 | Detail |
| 0.015 | Malignant neoplasm of stomach | MDR1 C3435T polymorphism has no influence on developing Helicobacter pylori infe... | BeFree | 18644389 | Detail |
| 0.097 | Malignant neoplasm of breast | Effect of ABCB1 C3435T polymorphism on docetaxel pharmacokinetics according to m... | BeFree | 20628376 | Detail |
| 0.004 | Drug Resistant Epilepsy | Association analysis of intractable epilepsy with C3435T and G2677T/A ABCB1 gene... | BeFree | 21636342 | Detail |
| <0.001 | bipolar disorder | Association of MDR1 C3435T polymorphism with bipolar disorder in patients treate... | BeFree | 18165917 | Detail |
| <0.001 | Coronary Arteriosclerosis | The association of MDR1 C3435T and G2677T/A polymorphisms with plasma platelet-a... | BeFree | 23816407 | Detail |
| 0.360 | Malignant neoplasm of breast | We aimed to determine the associations of genetic polymorphisms of excision repa... | BeFree | 24933103 | Detail |
| 0.194 | epilepsy | The study failed to corroborate association between polymorphism CYP3A5*3 and C3... | BeFree | 23984379 | Detail |
| 0.007 | Helicobacter pylori infection | The isolated C3435T ABCB1 SNP is not a major factor for genetic susceptibility t... | BeFree | 22001987 | Detail |
| 0.083 | HIV Infections | MDR1 C3435T genetic polymorphism does not influence the response to antiretrovir... | BeFree | 12853754 | Detail |
| <0.001 | glomerulonephritis | The CYP2B6*9 and ABCB1 C3435T polymorphisms alter the pharmacokinetics of cyclop... | BeFree | 22380717 | Detail |
| 0.006 | Epithelial ovarian cancer | Basal expression of the multidrug resistance gene 1 (MDR-1) is associated with t... | BeFree | 12142082 | Detail |
| 0.236 | Pain | Single-nucleotide polymorphisms in OPRM1 gene (opioid receptor, A118G), ABCB1 ge... | BeFree | 25576257 | Detail |
| 0.054 | ulcerative colitis | The frequency of C3435T MDR1 gene polymorphism in Iranian patients with ulcerati... | BeFree | 17242936 | Detail |
| <0.001 | Chronic pain | Polymorphisms of OPRM1 A118G and ABCB1 C3435T have been suggested to contribute ... | BeFree | 23803057 | Detail |
| 0.054 | ulcerative colitis | Association between the C3435T MDR1 gene polymorphism and susceptibility for ulc... | BeFree | 12512026 | Detail |
| 0.042 | breast carcinoma | Correlation of polymorphism C3435T of the MDR-1 gene and the response of primary... | BeFree | 18393221 | Detail |
| <0.001 | neutropenia | CYP2C8*3 and the ABCB1 SNPs C1236T, G2677T/A, and C3435T were not statistically ... | BeFree | 21327421 | Detail |
| <0.001 | organic sexual dysfunction | This study measured functionally implicated ABCB1 variants (rs2235015, rs1128503... | BeFree | 23356581 | Detail |
| <0.001 | Sickle Cell Dactylitis | The risk for mucosal inflammation was increased in the presence of the G allele ... | BeFree | 19667267 | Detail |
| 0.127 | Non-small cell lung carcinoma | Polymorphisms of ERCC1 C118T/C8092A and MDR1 C3435T predict outcome of platinum-... | BeFree | 21827803 | Detail |
| 0.013 | diffuse large B-cell lymphoma | The present study evaluated the impact of single gene polymorphisms (SNPs: rs180... | BeFree | 23829278 | Detail |
| 0.032 | multiple myeloma | ABCB1 (MDR1) rs1045642 is associated with increased overall survival in plasma c... | BeFree | 19373654 | Detail |
| <0.001 | Myoclonic Epilepsy, Juvenile | However, a significant association was observed between ABCB1 (C3435T) rs1045642... | BeFree | 24586633 | Detail |
| 0.042 | breast carcinoma | MDR1 C3435T polymorphism in patients with breast cancer. | BeFree | 17560460 | Detail |
| 0.097 | Malignant neoplasm of breast | We aimed to determine the associations of genetic polymorphisms of excision repa... | BeFree | 24933103 | Detail |
| 0.010 | Acute lymphocytic leukemia | Analysis of single nucleotide polymorphism C3435T of the multidrug resistance ge... | BeFree | 12851703 | Detail |
| 0.003 | Malignant neoplasm of esophagus | Impact of ABCB1 C3435T polymorphism on lymph node regression in multimodality tr... | BeFree | 21332314 | Detail |
| 0.006 | major depressive disorder | ABCB1 C3435T polymorphism is associated with susceptibility to major depression,... | BeFree | 24911075 | Detail |
| 0.042 | breast carcinoma | Polymorphism C3435T of the MDR-1 gene predict response to preoperative chemother... | BeFree | 19151448 | Detail |
| 0.009 | Acute coronary syndrome | Genetic polymorphisms of CYP2C19 2 and ABCB1 C3435T affect the pharmacokinetic a... | BeFree | 25542807 | Detail |
| 0.004 | Leukemia, Lymphocytic, Acute, L1 | Functional C3435T polymorphism of MDR1 gene: an impact on genetic susceptibility... | BeFree | 15059065 | Detail |
| 0.016 | myocardial infarction | Genetic C3435T polymorphism of the multidrug resistance gene-1 (MDR-1) limits or... | BeFree | 19784880 | Detail |
| 0.009 | Acute coronary syndrome | The current meta-analysis suggests that ABCB1 C3435T polymorphism may contribute... | BeFree | 24328528 | Detail |
| 0.002 | depressive disorder | Implication of P-glycoprotein in formation of depression-prone personality: asso... | BeFree | 24577069 | Detail |
| 0.097 | Malignant neoplasm of breast | MDR1 (C3435T) polymorphism: relation to the risk of breast cancer and therapeuti... | BeFree | 19752884 | Detail |
| 0.085 | Malignant neoplasm of breast | We aimed to determine the associations of genetic polymorphisms of excision repa... | BeFree | 24933103 | Detail |
| 0.042 | breast carcinoma | Association between MDR1 C3435T polymorphism and risk of breast cancer. | BeFree | 24070710 | Detail |
| <0.001 | Myocardial Ischemia | ABCB1 C3435T polymorphism and the risk of ischemic heart disease: a meta-analysi... | BeFree | 25118983 | Detail |
| 0.097 | Malignant neoplasm of breast | Association between MDR1 C3435T polymorphism and risk of breast cancer. | BeFree | 24070710 | Detail |
| 0.006 | leukopenia | Serum LDH may be a promising predictor of prognosis, and the ABCB1 C3435T polymo... | BeFree | 21706123 | Detail |
| 0.194 | epilepsy | Multidrug resistance 1 (MDR1) 3435C/T genotyping in childhood drug-resistant epi... | BeFree | 23465586 | Detail |
| 0.194 | epilepsy | Previous studies have attempted to confirm the association between the ABCB1-C34... | BeFree | 24794827 | Detail |
| 0.054 | ulcerative colitis | This was a case-control analysis of MDR1 C3435T and G2677T SNPs in a large well-... | BeFree | 15685540 | Detail |
| 0.121 | congenital heart defects | General maternal medication use, folic acid, the MDR1 C3435T polymorphism, and t... | BeFree | 21183151 | Detail |
| <0.001 | Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | P-glycoprotein expression in Helicobacter pylori-positive patients: the influenc... | BeFree | 22788927 | Detail |
| 0.130 | neutropenia | In addition, a statistically significant association was found among neutropenia... | BeFree | 25007187 | Detail |
| 0.121 | congenital heart defects | Increased risk for congenital heart defects in children carrying the ABCB1 Gene ... | BeFree | 23874772 | Detail |
| 0.008 | Cerebrovascular accident | Therefore the present study was taken up to investigate the role of C3435T polym... | BeFree | 22177087 | Detail |
| 0.006 | coronary artery disease | The association of MDR1 C3435T and G2677T/A polymorphisms with plasma platelet-a... | BeFree | 23816407 | Detail |
| 0.009 | Acute coronary syndrome | Influence of C3435T multidrug resistance gene-1 (MDR-1) polymorphism on platelet... | BeFree | 19784880 | Detail |
| 0.018 | epilepsy | To assess the role of MDR1 and gamma-aminobutyric acid receptor-gamma 2 sub unit... | BeFree | 22239287 | Detail |
| 0.097 | Malignant neoplasm of breast | Association of C3435T single-nucleotide polymorphism of MDR1 gene with breast ca... | BeFree | 19388849 | Detail |
| 0.097 | Malignant neoplasm of breast | MDR1 C3435T polymorphism in Mexican patients with breast cancer. | BeFree | 25062490 | Detail |
| 0.002 | Acute lymphocytic leukemia | To investigate their possible roles in disease susceptibility and some disease c... | BeFree | 18243305 | Detail |
| 0.194 | epilepsy | ABCB1 gene C3435T polymorphism and drug resistance in epilepsy: evidence based o... | BeFree | 25799371 | Detail |
| 0.014 | schizophrenia | The present study does not suggest a major influence of MDR1 G2677T/A and C3435T... | BeFree | 20060871 | Detail |
| 0.008 | chronic lymphocytic leukemia | MDR1 (ABCB1) gene polymorphism C3435T is associated with P-glycoprotein activity... | BeFree | 17085864 | Detail |
| 0.194 | epilepsy | Studies on epilepsy have focused on the C3435T polymorphism of the ABCB1 gene, b... | BeFree | 19167193 | Detail |
| 0.006 | coronary artery disease | ABCB1 C3435T polymorphism and response to clopidogrel treatment in coronary arte... | BeFree | 23056288 | Detail |
| 0.003 | Carcinogenesis | The multidrug resistance 1 gene (MDR1) C3435T polymorphism has been demonstrated... | BeFree | 24815441 | Detail |
| 0.006 | Unipolar Depression | ABCB1 C3435T polymorphism is associated with susceptibility to major depression,... | BeFree | 24911075 | Detail |
| 0.013 | colon carcinoma | Genetic testing for C3435T MDR1 gene polymorphism may be a suitable test to eval... | BeFree | 15912392 | Detail |
| 0.194 | epilepsy | Association between ABCB1 C3435T polymorphism and drug-resistant epilepsy in Han... | BeFree | 17521963 | Detail |
| 0.004 | Drug Resistant Epilepsy | Association of MDR1 gene C3435T polymorphism with childhood intractable epilepsy... | BeFree | 24553780 | Detail |
| 0.194 | epilepsy | The relationship established in a subset of the Chinese population between the M... | BeFree | 24953225 | Detail |
| 0.001 | Coronary heart disease | The association of MDR1 C3435T and G2677T/A polymorphisms with plasma platelet-a... | BeFree | 23816407 | Detail |
| 0.006 | Seizures | Role of MDR1 C3435T and GABRG2 C588T gene polymorphisms in seizure occurrence an... | BeFree | 22239287 | Detail |
| <0.001 | glomerulonephritis | The CYP2B6*9 and ABCB1 C3435T polymorphisms alter the pharmacokinetics of cyclop... | BeFree | 22380717 | Detail |
| <0.001 | Palmar-plantar erythrodysesthesia syndrome | The risk for mucosal inflammation was increased in the presence of the G allele ... | BeFree | 19667267 | Detail |
| 0.055 | leukemia | Variant genotypes of MDR1 C3435T increase the risk of leukemia: evidence from 10... | BeFree | 22088099 | Detail |
| 0.014 | schizophrenia | The present study was therefore designed to examine whether the major polymorphi... | BeFree | 16386826 | Detail |
| 0.240 | Malignant neoplasm of breast | Polymorphism C3435T of the MDR-1 gene predict response to preoperative chemother... | BeFree | 19151448 | Detail |
| 0.012 | glioblastoma | Although the C3435T polymorphism does not appear to be associated with other typ... | BeFree | 15947495 | Detail |
| 0.013 | leukopenia | PG analysis showed that ABCB1 (C3435T)T/T (membrane transport) was associated wi... | BeFree | 19349543 | Detail |
| <0.001 | cannabis dependence | Association between ABCB1 C3435T polymorphism and increased risk of cannabis dep... | BeFree | 19625010 | Detail |
| 0.022 | Inflammatory Bowel Diseases | C3435T polymorphism of the ABCB1/MDR1 gene encoding P-glycoprotein in patients w... | BeFree | 22661185 | Detail |
| 0.042 | breast carcinoma | MDR1 (C3435T) polymorphism: relation to the risk of breast cancer and therapeuti... | BeFree | 19752884 | Detail |
| 0.146 | Homocysteinemia | All subjects were genotyped for 13 polymorphic variants in the genes of xenobiot... | BeFree | 23107763 | Detail |
| <0.001 | esophageal carcinoma | Impact of ABCB1 C3435T polymorphism on lymph node regression in multimodality tr... | BeFree | 21332314 | Detail |
| <0.001 | Homocysteinemia | All subjects were genotyped for 13 polymorphic variants in the genes of xenobiot... | BeFree | 23107763 | Detail |
| 0.008 | breast carcinoma | We aimed to determine the associations of genetic polymorphisms of excision repa... | BeFree | 24933103 | Detail |
| 0.164 | Seizures | C3435T polymorphism of ABCB1 gene was demonstrated in vivo to significantly infl... | BeFree | 18329296 | Detail |
| 0.097 | Malignant neoplasm of breast | Polymorphism C3435T of the MDR-1 gene predicts response to preoperative chemothe... | BeFree | 12684679 | Detail |
| 0.006 | breast carcinoma | We aimed to determine the associations of genetic polymorphisms of excision repa... | BeFree | 24933103 | Detail |
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| A total of 57 women with HER2-positive metastatic breast cancer were analyzed after taxane plus tras... | CIViC Evidence | Detail |
| The mutation at codon 3435 (C>T) correlated with a significantly higher response rate to platinum-ba... | CIViC Evidence | Detail |
| NM_001348946.2(ABCB1):c.3435T>C (p.Ile1145=) AND MDR1 POLYMORPHISM | ClinVar | Detail |
| NM_001348946.2(ABCB1):c.3435T>C (p.Ile1145=) AND Non-small cell lung carcinoma | ClinVar | Detail |
| NM_001348946.2(ABCB1):c.3435T>C (p.Ile1145=) AND not provided | ClinVar | Detail |
| NM_001348946.2(ABCB1):c.3435T>C (p.Ile1145=) AND Tramadol response | ClinVar | Detail |
| NM_001348946.2(ABCB1):c.3435T>C (p.Ile1145=) AND ABCB1-related disorder | ClinVar | Detail |
| In irinotecan-treated patients, T allele of ABCB1C1236T SNP was associated with a lower risk of asth... | DisGeNET | Detail |
| Polymorphism C3435T of the MDR-1 gene predict response to preoperative chemotherapy in locally advan... | DisGeNET | Detail |
| Functional MDR1 polymorphisms (G2677T and C3435T) and TCF4 mutations in colorectal tumors with high ... | DisGeNET | Detail |
| MDR1 single nucleotide polymorphism C3435T in Turkish patients with non-small-cell lung cancer. | DisGeNET | Detail |
| Our data suggested that MDR1 C3435T or G2677T/A gene polymorphisms are risk factors of increased sus... | DisGeNET | Detail |
| Prevalence of MDR1 C3435T and CYP2B6 G516T polymorphisms among HIV-1 infected South African patients... | DisGeNET | Detail |
| Different frequencies and effects of ABCB1 T3435C polymorphism on clinical and laboratory features o... | DisGeNET | Detail |
| Analysis of single nucleotide polymorphism C3435T of the multidrug resistance gene MDR1 in acute lym... | DisGeNET | Detail |
| To determine the influence of the MDR1 C3435T polymorphism on the development of childhood acute lym... | DisGeNET | Detail |
| CYP2C8*3 and the ABCB1 SNPs C1236T, G2677T/A, and C3435T were not statistically significantly correl... | DisGeNET | Detail |
| Association between the C3435T polymorphism of ABCB1/MDR1 gene (rs1045642) and colorectal cancer sus... | DisGeNET | Detail |
| We aimed to determine the associations of genetic polymorphisms of excision repair cross-complementa... | DisGeNET | Detail |
| In regard to the clinical implications of MDR1 SNPs, it was found in large meta-analysis that C3435T... | DisGeNET | Detail |
| The C3435T polymorphism of the MDR-1 gene influences ADP dependent platelet reactivity in patients w... | DisGeNET | Detail |
| We aimed to determine the associations of genetic polymorphisms of excision repair cross-complementa... | DisGeNET | Detail |
| Thus, detection of ABCB1 C3435T polymorphism may be a promising biomarker for the early detection of... | DisGeNET | Detail |
| MDR1 C3435T and C1236T polymorphisms: association with high-risk childhood acute lymphoblastic leuke... | DisGeNET | Detail |
| MDR1 C3435T polymorphism in patients with breast cancer. | DisGeNET | Detail |
| The risk for mucosal inflammation was increased in the presence of the G allele in CYP1A1 2455A/G (O... | DisGeNET | Detail |
| Analysis of common MDR1 (ABCB1) gene C1236T and C3435T polymorphisms in Turkish patients with famili... | DisGeNET | Detail |
| The significance of C3435T point mutation of the MDR1 gene in endometrial cancer. | DisGeNET | Detail |
| Implication of P-glycoprotein in formation of depression-prone personality: association study betwee... | DisGeNET | Detail |
| PG analysis showed that ABCB1 (C3435T)T/T (membrane transport) was associated with IP-related diarrh... | DisGeNET | Detail |
| All subjects were genotyped for 13 polymorphic variants in the genes of xenobiotics detoxification C... | DisGeNET | Detail |
| PG analysis showed that ABCB1 (C3435T)T/T (membrane transport) was associated with IP-related diarrh... | DisGeNET | Detail |
| ABCB1 rs1045642, ABCC3 rs4793665, and SLC19A1 rs1051266 polymorphisms were associated with response ... | DisGeNET | Detail |
| Our results indicate that C3435T polymorphism in exon 26 of MDR1 gene is associated with colchicine ... | DisGeNET | Detail |
| These data suggest that the presence of the MTHFR C677T and ABCB1 C3435T SNPs contribute to MTX toxi... | DisGeNET | Detail |
| We aimed to determine the associations of genetic polymorphisms of excision repair cross-complementa... | DisGeNET | Detail |
| The influence of C3435T polymorphism of ABCB1 gene on penetration of phenobarbital across the blood-... | DisGeNET | Detail |
| The available evidence indicates that MDR1 C3435T polymorphism cannot be considered as a reliable pr... | DisGeNET | Detail |
| We aimed to determine the associations of genetic polymorphisms of excision repair cross-complementa... | DisGeNET | Detail |
| No correlation was observed between the C3435T polymorphism of the MDR1 gene and GC risk or prognosi... | DisGeNET | Detail |
| Impact of ABCB1 C3435T polymorphism on lymph node regression in multimodality treatment of locally a... | DisGeNET | Detail |
| MDR1 C3435T polymorphism and childhood acute lymphoblastic leukemia susceptibility: an updated meta-... | DisGeNET | Detail |
| ) to standard-dose clopidogrel (75 mg/d) (TRIPLE) compared with double-dose clopidogrel (150 mg/d) (... | DisGeNET | Detail |
| The distribution of TSER (TYMS), C677T (MTHFR), Arg72Pro (p53) and C3435T (MDR1) gene polymorphisms ... | DisGeNET | Detail |
| We studied the influence of AIDS restriction genes (ARGs) CCR5-Delta32, CCR2-64I, SDF1-3'A, IL10-5'A... | DisGeNET | Detail |
| Correlation of polymorphism C3435T of the MDR-1 gene and the response of primary chemotherapy in wom... | DisGeNET | Detail |
| PG analysis showed that ABCB1 (C3435T)T/T (membrane transport) was associated with IP-related diarrh... | DisGeNET | Detail |
| Polymorphism C3435T of the MDR-1 gene predicts response to preoperative chemotherapy in locally adva... | DisGeNET | Detail |
| In this study, 3 genotypes of MDR1, 4 genotypes of MRP1, and 6 genotypes of MRP2 were additionally e... | DisGeNET | Detail |
| The study failed to corroborate association between polymorphism CYP3A5*3 and C3435T polymorphism in... | DisGeNET | Detail |
| MDR1 C3435T polymorphism has no influence on developing Helicobacter pylori infection-related gastri... | DisGeNET | Detail |
| MDR1 C3435T polymorphism has no influence on developing Helicobacter pylori infection-related gastri... | DisGeNET | Detail |
| The purpose of this study is to compare the genotype frequency of C3435T and G1199A polymorphisms in... | DisGeNET | Detail |
| In summary, this meta-analysis suggests that the MDR1 C3435T polymorphism is associated with cancer ... | DisGeNET | Detail |
| A total of 211 patients with Crohn's disease (CD), 97 patients with ulcerative colitis (UC), and 212... | DisGeNET | Detail |
| The MDR1 variant C3435T was associated with disease behavior in CD (OR = 1.45, 95% CI = 1.01-2.08, P... | DisGeNET | Detail |
| ABCB1 rs1045642, ABCC3 rs4793665, and SLC19A1 rs1051266 polymorphisms were associated with response ... | DisGeNET | Detail |
| Polymorphism of the multidrug resistance 1 gene MDR1/ABCB1 C3435T and response to antiepileptic drug... | DisGeNET | Detail |
| Polymorphism C3435T of the MDR-1 gene predict response to preoperative chemotherapy in locally advan... | DisGeNET | Detail |
| Is the MDR1 C3435T polymorphism responsible for oral mucositis in children with acute lymphoblastic ... | DisGeNET | Detail |
| We aimed to determine the associations of genetic polymorphisms of excision repair cross-complementa... | DisGeNET | Detail |
| MDR1 C3435T polymorphism influences the development of colon cancer and adult acute myeloid leukemia... | DisGeNET | Detail |
| The aim of the study was to evaluate the influence of the MDR1 C3435T polymorphism on the therapeuti... | DisGeNET | Detail |
| Functional MDR1 polymorphisms (G2677T and C3435T) and TCF4 mutations in colorectal tumors with high ... | DisGeNET | Detail |
| Prevalence of MDR1 C3435T and CYP2B6 G516T polymorphisms among HIV-1 infected South African patients... | DisGeNET | Detail |
| This study measured functionally implicated ABCB1 variants (rs2235015, rs1128503, rs2032582, and rs1... | DisGeNET | Detail |
| MDR1 C3435T polymorphism in Mexican children with acute lymphoblastic leukemia and in healthy indivi... | DisGeNET | Detail |
| The aim of this study was to investigate the influence of CYP3A5 A6986G, ABCB1 (C3435T and G2677T), ... | DisGeNET | Detail |
| ) to standard-dose clopidogrel (75 mg/d) (TRIPLE) compared with double-dose clopidogrel (150 mg/d) (... | DisGeNET | Detail |
| We studied the influence of AIDS restriction genes (ARGs) CCR5-Delta32, CCR2-64I, SDF1-3'A, IL10-5'A... | DisGeNET | Detail |
| Lack of association of the MDR1 C3435T polymorphism with susceptibility to gastric cancer and peptic... | DisGeNET | Detail |
| PG analysis showed that ABCB1 (C3435T)T/T (membrane transport) was associated with IP-related diarrh... | DisGeNET | Detail |
| The drug-transporter gene MDR1 C3435T and G2677T/A polymorphisms and the risk of multidrug-resistant... | DisGeNET | Detail |
| In regard to the clinical implications of MDR1 SNPs, it was found in large meta-analysis that C3435T... | DisGeNET | Detail |
| MDR1 C3435T polymorphism influences the development of colon cancer and adult acute myeloid leukemia... | DisGeNET | Detail |
| [In conclusion, ABCB1 and ABCC1 mRNA levels in PBMC are modulated by atorvastatin and ABCB1 G2677T/A... | DisGeNET | Detail |
| All the case-control association researches evaluating the role of MDR1 C3435T polymorphism in child... | DisGeNET | Detail |
| Effect of MDR1 C3435T polymorphism on cure rates of Helicobacter pylori infection by triple therapy ... | DisGeNET | Detail |
| The C3435T polymorphism of MDR1 and susceptibility to adult glioma. | DisGeNET | Detail |
| The C3435T (rs1045642) polymorphism, located in multi-drug resistance gene 1 (MDR1), has demonstrate... | DisGeNET | Detail |
| All subjects were genotyped for 13 polymorphic variants in the genes of xenobiotics detoxification C... | DisGeNET | Detail |
| We aimed to determine the associations of genetic polymorphisms of excision repair cross-complementa... | DisGeNET | Detail |
| Genetic testing for C3435T MDR1 gene polymorphism may be a suitable test to evaluate the risk for co... | DisGeNET | Detail |
| These data suggest that the presence of the MTHFR C677T and ABCB1 C3435T SNPs contribute to MTX toxi... | DisGeNET | Detail |
| Association of an MDR1 gene (C3435T) polymorphism with acute leukemia in India. | DisGeNET | Detail |
| In irinotecan-treated patients, T allele of ABCB1C1236T SNP was associated with a lower risk of asth... | DisGeNET | Detail |
| Functional MDR1 polymorphisms (G2677T and C3435T) and TCF4 mutations in colorectal tumors with high ... | DisGeNET | Detail |
| Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to r... | DisGeNET | Detail |
| The aim of our study was to investigate the relationship between C3435T polymorphism of the MDR1 gen... | DisGeNET | Detail |
| MDR1 gene C3435T polymorphism is associated with clinical outcomes in gastric cancer patients treate... | DisGeNET | Detail |
| ABCB1 C3435T polymorphism and the risk of resistance to antiepileptic drugs in epilepsy: a systemati... | DisGeNET | Detail |
| We assessed the MDR1 C3435T polymorphism in H. pylori-positive gastritis alone patients (n=150), gas... | DisGeNET | Detail |
| MDR1 C3435T polymorphism and inflammatory bowel disease risk: a meta-analysis. | DisGeNET | Detail |
| ) to standard-dose clopidogrel (75 mg/d) (TRIPLE) compared with double-dose clopidogrel (150 mg/d) (... | DisGeNET | Detail |
| MDR1 C3435T polymorphism in Mexican children with acute lymphoblastic leukemia and in healthy indivi... | DisGeNET | Detail |
| In this study, 3 genotypes of MDR1, 4 genotypes of MRP1, and 6 genotypes of MRP2 were additionally e... | DisGeNET | Detail |
| Is the MDR1 C3435T polymorphism responsible for oral mucositis in children with acute lymphoblastic ... | DisGeNET | Detail |
| [ABCB1 (MDR1) rs1045642 is associated with increased overall survival in plasma cell myeloma.] | DisGeNET | Detail |
| CYP2C8*3 and the ABCB1 SNPs C1236T, G2677T/A, and C3435T were not statistically significantly correl... | DisGeNET | Detail |
| Association of ABCB1 C3435T polymorphism with phenobarbital resistance in Thai patients with epileps... | DisGeNET | Detail |
| The distribution of TSER (TYMS), C677T (MTHFR), Arg72Pro (p53) and C3435T (MDR1) gene polymorphisms ... | DisGeNET | Detail |
| these results suggest that MDR1 C3435T polymorphism might play a role in HL occurrence; however this... | DisGeNET | Detail |
| Role of MDR1 C3435T and GABRG2 C588T gene polymorphisms in seizure occurrence and MDR1 effect on ant... | DisGeNET | Detail |
| Thus, detection of ABCB1 C3435T polymorphism may be a promising biomarker for the early detection of... | DisGeNET | Detail |
| Association between the MDR1 gene variant C3435T and risk of leukaemia: a meta-analysis. | DisGeNET | Detail |
| Variant genotypes of APOAI -2500C/T, CETP 405I/V, and ABCB1 3435C/T showed higher risk of myocardial... | DisGeNET | Detail |
| MDR1 C3435T polymorphism has no influence on developing Helicobacter pylori infection-related gastri... | DisGeNET | Detail |
| PG analysis showed that ABCB1 (C3435T)T/T (membrane transport) was associated with IP-related diarrh... | DisGeNET | Detail |
| We investigated whether polymorphisms in MDR1 (T-129C, C1236T and C3435T) and PXR (C63396T) affect l... | DisGeNET | Detail |
| Basal expression of the multidrug resistance gene 1 (MDR-1) is associated with the TT genotype at th... | DisGeNET | Detail |
| MDR1 gene C3435T polymorphism is associated with clinical outcomes in gastric cancer patients treate... | DisGeNET | Detail |
| We included all published studies until September 2007, in which patients with responsive and unresp... | DisGeNET | Detail |
| Our study represents the largest analysis of ABCB1 SNPs and EOC progression and survival to date, bu... | DisGeNET | Detail |
| The C3435T polymorphism in the ABCB1 gene of fetus increases the risks of CHD in a Han Chinese popul... | DisGeNET | Detail |
| We aimed to determine the associations of genetic polymorphisms of excision repair cross-complementa... | DisGeNET | Detail |
| Single-nucleotide polymorphisms in OPRM1 gene (opioid receptor, A118G), ABCB1 gene (opioid transport... | DisGeNET | Detail |
| We aimed to determine the associations of genetic polymorphisms of excision repair cross-complementa... | DisGeNET | Detail |
| MDR1 C3435T polymorphism influences the development of colon cancer and adult acute myeloid leukemia... | DisGeNET | Detail |
| Genetic polymorphisms of CYP2C19 2 and ABCB1 C3435T affect the pharmacokinetic and pharmacodynamic r... | DisGeNET | Detail |
| In summary, this meta-analysis suggests that the MDR1 C3435T polymorphism is associated with cancer ... | DisGeNET | Detail |
| The present study evaluated the impact of single gene polymorphisms (SNPs: rs1801133 and rs1801131 i... | DisGeNET | Detail |
| The aim of the study was to evaluate the influence of the MDR1 C3435T polymorphism on the therapeuti... | DisGeNET | Detail |
| ABCB1 C3435T polymorphism influences the risk for Alzheimer's disease. | DisGeNET | Detail |
| Single-nucleotide polymorphisms in OPRM1 gene (opioid receptor, A118G), ABCB1 gene (opioid transport... | DisGeNET | Detail |
| In irinotecan-treated patients, T allele of ABCB1C1236T SNP was associated with a lower risk of asth... | DisGeNET | Detail |
| In irinotecan-treated patients, T allele of ABCB1C1236T SNP was associated with a lower risk of asth... | DisGeNET | Detail |
| In this study, 3 genotypes of MDR1, 4 genotypes of MRP1, and 6 genotypes of MRP2 were additionally e... | DisGeNET | Detail |
| In this study, 3 genotypes of MDR1, 4 genotypes of MRP1, and 6 genotypes of MRP2 were additionally e... | DisGeNET | Detail |
| MDR1 single nucleotide polymorphism C3435T in normal colorectal tissue and colorectal carcinomas det... | DisGeNET | Detail |
| This study failed to corroborate a previously reported association between the C3435T polymorphism i... | DisGeNET | Detail |
| The significance of C3435T point mutation of the MDR1 gene in endometrial cancer. | DisGeNET | Detail |
| Polymorphisms of OPRM1 A118G and ABCB1 C3435T have been suggested to contribute to inter-individual ... | DisGeNET | Detail |
| Single-nucleotide polymorphism C3435T in the ABCB1 gene is associated with opioid consumption in pos... | DisGeNET | Detail |
| Significance of MDR1 gene polymorphism C3435T in predicting drug response in epilepsy. | DisGeNET | Detail |
| CYP2C8*3 and the ABCB1 SNPs C1236T, G2677T/A, and C3435T were not statistically significantly correl... | DisGeNET | Detail |
| Lack of association of the MDR1 C3435T polymorphism with susceptibility to gastric cancer and peptic... | DisGeNET | Detail |
| The C3435T polymorphism in the ABCB1 gene of fetus increases the risks of CHD in a Han Chinese popul... | DisGeNET | Detail |
| The risk for mucosal inflammation was increased in the presence of the G allele in CYP1A1 2455A/G (O... | DisGeNET | Detail |
| Three ABCB1 SNPs (C1236T, G2677T, and C3435T) were genotyped in 100 Egyptian patients with CML under... | DisGeNET | Detail |
| Role of MDR1 C3435T and GABRG2 C588T gene polymorphisms in seizure occurrence and MDR1 effect on ant... | DisGeNET | Detail |
| No correlation was observed between the C3435T polymorphism of the MDR1 gene and GC risk or prognosi... | DisGeNET | Detail |
| We show that genotyping for ABCB1 variations (rs1045642 and rs2032582) may help predict HIV treatmen... | DisGeNET | Detail |
| Lack of association of the MDR1 C3435T polymorphism with susceptibility to gastric cancer and peptic... | DisGeNET | Detail |
| Effect of ABCB1 C3435T polymorphism on docetaxel pharmacokinetics according to menopausal status in ... | DisGeNET | Detail |
| CYP2C8*3 and the ABCB1 SNPs C1236T, G2677T/A, and C3435T were not statistically significantly correl... | DisGeNET | Detail |
| All subjects were genotyped for 13 polymorphic variants in the genes of xenobiotics detoxification C... | DisGeNET | Detail |
| Gene polymorphisms of OPRM1 A118G and ABCB1 C3435T may influence opioid requirements in Chinese pati... | DisGeNET | Detail |
| Polymorphism of ABCB1/MDR1 C3435T in children and adolescents with partial epilepsy is due to differ... | DisGeNET | Detail |
| A total of 211 patients with Crohn's disease (CD), 97 patients with ulcerative colitis (UC), and 212... | DisGeNET | Detail |
| MDR1 C3435T polymorphism is predictive of later onset of ulcerative colitis in Japanese. | DisGeNET | Detail |
| Association of C3435T single-nucleotide polymorphism of MDR1 gene with breast cancer in an Iranian p... | DisGeNET | Detail |
| The present study examined the association of ABCB1 C3435T and G2677T/A in a large British case-cont... | DisGeNET | Detail |
| We aimed to determine the associations of genetic polymorphisms of excision repair cross-complementa... | DisGeNET | Detail |
| MDR1 C3435T polymorphism in Mexican patients with breast cancer. | DisGeNET | Detail |
| The significance of C3435T point mutation of the MDR1 gene in endometrial cancer. | DisGeNET | Detail |
| Association of MDR1 (C3435T) polymorphism and resistance to carbamazepine in epileptic patients from... | DisGeNET | Detail |
| Lack of association between C3435T nucleotide MDR1 genetic polymorphism and multidrug-resistant epil... | DisGeNET | Detail |
| C3435T polymorphism of the ABCB1 gene: impact on genetic susceptibility to peptic ulcers. | DisGeNET | Detail |
| Association between the functional polymorphism (C3435T) of the gene encoding P-glycoprotein (ABCB1)... | DisGeNET | Detail |
| CYP2C8*3 and the ABCB1 SNPs C1236T, G2677T/A, and C3435T were not statistically significantly correl... | DisGeNET | Detail |
| Association between MDR1 C3435T polymorphism and refractory epilepsy in the Chinese population: a sy... | DisGeNET | Detail |
| Association analysis of three ABCB1 (MDR1) gene variants (C1236T, G2677A/T and C3435T) and their gen... | DisGeNET | Detail |
| Association between the C3435T polymorphism of ABCB1/MDR1 gene (rs1045642) and colorectal cancer sus... | DisGeNET | Detail |
| Association between the functional polymorphism (C3435T) of the gene encoding P-glycoprotein (ABCB1)... | DisGeNET | Detail |
| ABCB1 C3435T polymorphism and the risk of coronary heart disease: a meta-analysis. | DisGeNET | Detail |
| We aimed to determine the associations of genetic polymorphisms of excision repair cross-complementa... | DisGeNET | Detail |
| MDR-1 polymorphisms (G2677T and C3435T) in B-chronic lymphocytic leukemia: an impact on susceptibili... | DisGeNET | Detail |
| Influence of ABCB-1 C3435T polymorphisms on plasma nevirapine and efavirenz levels and their effects... | DisGeNET | Detail |
| MDR1 C3435T polymorphism associated with the development of clinical features in Behçet's disease in... | DisGeNET | Detail |
| The present study does not suggest a major influence of MDR1 G2677T/A and C3435T polymorphisms on tr... | DisGeNET | Detail |
| The association of ABCB1-C3435T with risk of drug-resistance was significant in the overall populati... | DisGeNET | Detail |
| This was a case-control analysis of MDR1 C3435T and G2677T SNPs in a large well-characterized Scotti... | DisGeNET | Detail |
| In addition, a statistically significant association was found among neutropenia (absolute neutrophi... | DisGeNET | Detail |
| In regard to the clinical implications of MDR1 SNPs, it was found in large meta-analysis that C3435T... | DisGeNET | Detail |
| The aim of this study was to investigate the influence of CYP3A5 A6986G, ABCB1 (C3435T and G2677T), ... | DisGeNET | Detail |
| Evaluation of the C3435T polymorphism in the MDR1 gene in patients with hepatocellular carcinoma. | DisGeNET | Detail |
| The available evidence indicates that MDR1 C3435T polymorphism cannot be considered as a reliable pr... | DisGeNET | Detail |
| ABCB1 C3435T polymorphism influences methotrexate sensitivity in rheumatoid arthritis patients. | DisGeNET | Detail |
| We aimed to determine the associations of genetic polymorphisms of excision repair cross-complementa... | DisGeNET | Detail |
| ABCB1 C3435T polymorphism and the risk of coronary heart disease: a meta-analysis. | DisGeNET | Detail |
| ) to standard-dose clopidogrel (75 mg/d) (TRIPLE) compared with double-dose clopidogrel (150 mg/d) (... | DisGeNET | Detail |
| MDR1 C3435T polymorphism has no influence on developing Helicobacter pylori infection-related gastri... | DisGeNET | Detail |
| Effect of ABCB1 C3435T polymorphism on docetaxel pharmacokinetics according to menopausal status in ... | DisGeNET | Detail |
| Association analysis of intractable epilepsy with C3435T and G2677T/A ABCB1 gene polymorphisms in Ir... | DisGeNET | Detail |
| Association of MDR1 C3435T polymorphism with bipolar disorder in patients treated with valproic acid... | DisGeNET | Detail |
| The association of MDR1 C3435T and G2677T/A polymorphisms with plasma platelet-activating factor lev... | DisGeNET | Detail |
| We aimed to determine the associations of genetic polymorphisms of excision repair cross-complementa... | DisGeNET | Detail |
| The study failed to corroborate association between polymorphism CYP3A5*3 and C3435T polymorphism in... | DisGeNET | Detail |
| The isolated C3435T ABCB1 SNP is not a major factor for genetic susceptibility to peptic ulcer, but ... | DisGeNET | Detail |
| MDR1 C3435T genetic polymorphism does not influence the response to antiretroviral therapy in drug-n... | DisGeNET | Detail |
| The CYP2B6*9 and ABCB1 C3435T polymorphisms alter the pharmacokinetics of cyclophosphamide and 4-hyd... | DisGeNET | Detail |
| Basal expression of the multidrug resistance gene 1 (MDR-1) is associated with the TT genotype at th... | DisGeNET | Detail |
| Single-nucleotide polymorphisms in OPRM1 gene (opioid receptor, A118G), ABCB1 gene (opioid transport... | DisGeNET | Detail |
| The frequency of C3435T MDR1 gene polymorphism in Iranian patients with ulcerative colitis. | DisGeNET | Detail |
| Polymorphisms of OPRM1 A118G and ABCB1 C3435T have been suggested to contribute to inter-individual ... | DisGeNET | Detail |
| Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis. | DisGeNET | Detail |
| Correlation of polymorphism C3435T of the MDR-1 gene and the response of primary chemotherapy in wom... | DisGeNET | Detail |
| CYP2C8*3 and the ABCB1 SNPs C1236T, G2677T/A, and C3435T were not statistically significantly correl... | DisGeNET | Detail |
| This study measured functionally implicated ABCB1 variants (rs2235015, rs1128503, rs2032582, and rs1... | DisGeNET | Detail |
| The risk for mucosal inflammation was increased in the presence of the G allele in CYP1A1 2455A/G (O... | DisGeNET | Detail |
| Polymorphisms of ERCC1 C118T/C8092A and MDR1 C3435T predict outcome of platinum-based chemotherapies... | DisGeNET | Detail |
| The present study evaluated the impact of single gene polymorphisms (SNPs: rs1801133 and rs1801131 i... | DisGeNET | Detail |
| ABCB1 (MDR1) rs1045642 is associated with increased overall survival in plasma cell myeloma. | DisGeNET | Detail |
| However, a significant association was observed between ABCB1 (C3435T) rs1045642 and risk of having ... | DisGeNET | Detail |
| MDR1 C3435T polymorphism in patients with breast cancer. | DisGeNET | Detail |
| We aimed to determine the associations of genetic polymorphisms of excision repair cross-complementa... | DisGeNET | Detail |
| Analysis of single nucleotide polymorphism C3435T of the multidrug resistance gene MDR1 in acute lym... | DisGeNET | Detail |
| Impact of ABCB1 C3435T polymorphism on lymph node regression in multimodality treatment of locally a... | DisGeNET | Detail |
| ABCB1 C3435T polymorphism is associated with susceptibility to major depression, but not with a clin... | DisGeNET | Detail |
| Polymorphism C3435T of the MDR-1 gene predict response to preoperative chemotherapy in locally advan... | DisGeNET | Detail |
| Genetic polymorphisms of CYP2C19 2 and ABCB1 C3435T affect the pharmacokinetic and pharmacodynamic r... | DisGeNET | Detail |
| Functional C3435T polymorphism of MDR1 gene: an impact on genetic susceptibility and clinical outcom... | DisGeNET | Detail |
| Genetic C3435T polymorphism of the multidrug resistance gene-1 (MDR-1) limits oral bioavailability o... | DisGeNET | Detail |
| The current meta-analysis suggests that ABCB1 C3435T polymorphism may contribute to the risk of CHD,... | DisGeNET | Detail |
| Implication of P-glycoprotein in formation of depression-prone personality: association study betwee... | DisGeNET | Detail |
| MDR1 (C3435T) polymorphism: relation to the risk of breast cancer and therapeutic outcome. | DisGeNET | Detail |
| We aimed to determine the associations of genetic polymorphisms of excision repair cross-complementa... | DisGeNET | Detail |
| Association between MDR1 C3435T polymorphism and risk of breast cancer. | DisGeNET | Detail |
| ABCB1 C3435T polymorphism and the risk of ischemic heart disease: a meta-analysis. | DisGeNET | Detail |
| Association between MDR1 C3435T polymorphism and risk of breast cancer. | DisGeNET | Detail |
| Serum LDH may be a promising predictor of prognosis, and the ABCB1 C3435T polymorphism may be a gene... | DisGeNET | Detail |
| Multidrug resistance 1 (MDR1) 3435C/T genotyping in childhood drug-resistant epilepsy. | DisGeNET | Detail |
| Previous studies have attempted to confirm the association between the ABCB1-C3435T polymorphism and... | DisGeNET | Detail |
| This was a case-control analysis of MDR1 C3435T and G2677T SNPs in a large well-characterized Scotti... | DisGeNET | Detail |
| General maternal medication use, folic acid, the MDR1 C3435T polymorphism, and the risk of a child w... | DisGeNET | Detail |
| P-glycoprotein expression in Helicobacter pylori-positive patients: the influence of MDR1 C3435T pol... | DisGeNET | Detail |
| In addition, a statistically significant association was found among neutropenia (absolute neutrophi... | DisGeNET | Detail |
| Increased risk for congenital heart defects in children carrying the ABCB1 Gene C3435T polymorphism ... | DisGeNET | Detail |
| Therefore the present study was taken up to investigate the role of C3435T polymorphism (rs 1045642)... | DisGeNET | Detail |
| The association of MDR1 C3435T and G2677T/A polymorphisms with plasma platelet-activating factor lev... | DisGeNET | Detail |
| Influence of C3435T multidrug resistance gene-1 (MDR-1) polymorphism on platelet reactivity and prog... | DisGeNET | Detail |
| To assess the role of MDR1 and gamma-aminobutyric acid receptor-gamma 2 sub unit (GABRG2) gene polym... | DisGeNET | Detail |
| Association of C3435T single-nucleotide polymorphism of MDR1 gene with breast cancer in an Iranian p... | DisGeNET | Detail |
| MDR1 C3435T polymorphism in Mexican patients with breast cancer. | DisGeNET | Detail |
| To investigate their possible roles in disease susceptibility and some disease characteristics we ge... | DisGeNET | Detail |
| ABCB1 gene C3435T polymorphism and drug resistance in epilepsy: evidence based on 8,604 subjects. | DisGeNET | Detail |
| The present study does not suggest a major influence of MDR1 G2677T/A and C3435T polymorphisms on tr... | DisGeNET | Detail |
| MDR1 (ABCB1) gene polymorphism C3435T is associated with P-glycoprotein activity in B-cell chronic l... | DisGeNET | Detail |
| Studies on epilepsy have focused on the C3435T polymorphism of the ABCB1 gene, but other ABC transpo... | DisGeNET | Detail |
| ABCB1 C3435T polymorphism and response to clopidogrel treatment in coronary artery disease (CAD) pat... | DisGeNET | Detail |
| The multidrug resistance 1 gene (MDR1) C3435T polymorphism has been demonstrated to influence the P-... | DisGeNET | Detail |
| ABCB1 C3435T polymorphism is associated with susceptibility to major depression, but not with a clin... | DisGeNET | Detail |
| Genetic testing for C3435T MDR1 gene polymorphism may be a suitable test to evaluate the risk for co... | DisGeNET | Detail |
| Association between ABCB1 C3435T polymorphism and drug-resistant epilepsy in Han Chinese. | DisGeNET | Detail |
| Association of MDR1 gene C3435T polymorphism with childhood intractable epilepsy: a meta-analysis. | DisGeNET | Detail |
| The relationship established in a subset of the Chinese population between the MDR1 C3435T polymorph... | DisGeNET | Detail |
| The association of MDR1 C3435T and G2677T/A polymorphisms with plasma platelet-activating factor lev... | DisGeNET | Detail |
| Role of MDR1 C3435T and GABRG2 C588T gene polymorphisms in seizure occurrence and MDR1 effect on ant... | DisGeNET | Detail |
| The CYP2B6*9 and ABCB1 C3435T polymorphisms alter the pharmacokinetics of cyclophosphamide and 4-hyd... | DisGeNET | Detail |
| The risk for mucosal inflammation was increased in the presence of the G allele in CYP1A1 2455A/G (O... | DisGeNET | Detail |
| Variant genotypes of MDR1 C3435T increase the risk of leukemia: evidence from 10 case-control studie... | DisGeNET | Detail |
| The present study was therefore designed to examine whether the major polymorphisms of MDR1 gene, C3... | DisGeNET | Detail |
| Polymorphism C3435T of the MDR-1 gene predict response to preoperative chemotherapy in locally advan... | DisGeNET | Detail |
| Although the C3435T polymorphism does not appear to be associated with other types of glioma, we can... | DisGeNET | Detail |
| PG analysis showed that ABCB1 (C3435T)T/T (membrane transport) was associated with IP-related diarrh... | DisGeNET | Detail |
| Association between ABCB1 C3435T polymorphism and increased risk of cannabis dependence. | DisGeNET | Detail |
| C3435T polymorphism of the ABCB1/MDR1 gene encoding P-glycoprotein in patients with inflammatory bow... | DisGeNET | Detail |
| MDR1 (C3435T) polymorphism: relation to the risk of breast cancer and therapeutic outcome. | DisGeNET | Detail |
| All subjects were genotyped for 13 polymorphic variants in the genes of xenobiotics detoxification C... | DisGeNET | Detail |
| Impact of ABCB1 C3435T polymorphism on lymph node regression in multimodality treatment of locally a... | DisGeNET | Detail |
| All subjects were genotyped for 13 polymorphic variants in the genes of xenobiotics detoxification C... | DisGeNET | Detail |
| We aimed to determine the associations of genetic polymorphisms of excision repair cross-complementa... | DisGeNET | Detail |
| C3435T polymorphism of ABCB1 gene was demonstrated in vivo to significantly influence the CSF/S PB c... | DisGeNET | Detail |
| Polymorphism C3435T of the MDR-1 gene predicts response to preoperative chemotherapy in locally adva... | DisGeNET | Detail |
| We aimed to determine the associations of genetic polymorphisms of excision repair cross-complementa... | DisGeNET | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- dbSNP
- rs1045642 dbSNP
- Genome
- hg38
- Position
- chr7:87,509,329-87,509,329
- Variant Type
- snv
- Reference Allele
- A
- Alternative Allele
- G
- Filtering Status (HGVD)
- PASS
- # of samples (HGVD)
- 1119
- Mean of sample read depth (HGVD)
- 39.23
- Standard deviation of sample read depth (HGVD)
- 22.69
- Number of reference allele (HGVD)
- 895
- Number of alternative allele (HGVD)
- 1341
- Allele Frequency (HGVD)
- 0.5997316636851521
- Gene Symbol (HGVD)
- ABCB1
- ToMMo VCF FILTER column value (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
- PASS
- Total VCF ID column value (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
- rs1045642
- Allele frequency, for each ALT allele (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
- 0.5825
- Allele count in genotypes, for each ALT allele (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
- 9761
- Total number of alleles in called genotypes (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
- 16758
- East Asian Chromosome Counts (ExAC)
- 8632
- East Asian Allele Counts (ExAC)
- 5391
- East Asian Heterozygous Counts (ExAC)
- 2001
- East Asian Homozygous Counts (ExAC)
- 1695
- East Asian Allele Frequency (ExAC)
- 0.6245366079703429
- Chromosome Counts in All Race (ExAC)
- 121366
- Allele Counts in All Race (ExAC)
- 61100
- Heterozygous Counts in All Race (ExAC)
- 28376
- Homozygous Counts in All Race (ExAC)
- 16362
- Allele Frequency in All Race (ExAC)
- 0.5034358881400063
- Variant (CIViC) (CIViC Variant)
- I1145I
- Transcript 1 (CIViC Variant)
- ENST00000265724.3
- Variant URL (CIViC Variant)
- https://civic.genome.wustl.edu/links/variants/263
- Summary (CIViC Variant)
- ABCB1 I1145I is a germline polymorphism that has improved responses in cancer. Specifically, it can indicate sensitivity to platinum-based chemotherapies for patients with NSCLC or better outcome for HER2-positive metastatic breast cancer patients.
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