Annotation Detail

Information
Associated Genes
ABCB1
Associated Variants
ABCB1 p.Ile1145= (p.I1145=) ( ENST00000265724.8, ENST00000543898.5, ENST00000622132.5 )
ABCB1 p.Ile1145= (p.I1145=) ( ENST00000265724.8, ENST00000543898.5, ENST00000622132.5 )
Associated Disease
lung non-small cell carcinoma
Source Database
CIViC Evidence
Description
The mutation at codon 3435 (C>T) correlated with a significantly higher response rate to platinum-based chemotherapy in patients with advanced non small cell lung cancer (NSCLC). 103 Chinese patients with NSCLC were evaluated in this study. However, there was not a significant correlation between the mutation and overall survival.
Variant Origin
Common Germline
Variant Origin
Common Germline
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/675
Gene URL
https://civic.genome.wustl.edu/links/genes/4244
Variant URL
https://civic.genome.wustl.edu/links/variants/263
Rating
2
Evidence Type
Predictive
Disease
Lung Non-small Cell Carcinoma
Evidence Direction
Supports
Drug
Cisplatin,Carboplatin
Evidence Level
B
Clinical Significance
Sensitivity/Response
Pubmed
22296372
Drugs
Drug NameSensitivitySupported
CarboplatinSensitivitytrue
CisplatinSensitivitytrue