chr22:19963748:G>A Detail (hg38) (COMT)
Information
Genome
Assembly | Position |
---|---|
hg19 | chr22:19,951,271-19,951,271 View the variant detail on this assembly version. |
hg38 | chr22:19,963,748-19,963,748 |
HGVS
Type | Transcript | Protein |
---|---|---|
RefSeq | NM_000754.3:c.472G>A | NP_000745.1:p.Val158Met |
NM_001135162.1:c.472G>A | NP_001128634.1:p.Val158Met | |
NM_007310.2:c.322G>A | NP_009294.1:p.Val108Met |
Summary
MGeND
Clinical significance | |
Variant entry | |
GWAS entry | |
Disease area statistics | Show details |
Frequency
JP | HGVD:0.310 |
ToMMo:0.317 | |
NCBN:[No Data.] | |
NCBN(Hondo):[No Data.] | |
NCBN(Ryukyu):[No Data.] | |
East asia | ExAC:0.285 |
Prediction
ClinVar
Clinical Significance |
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Review star | ![]() |
Show details |
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
Clinical significance | Last evaluated | Review status | Condition | Origin | Links |
---|---|---|---|---|---|
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2011-01-01 | no assertion criteria provided | CATECHOL-O-METHYLTRANSFERASE POLYMORPHISM |
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Detail |
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criteria provided, single submitter | not specified |
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Detail | |
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2018-04-28 | no assertion criteria provided |
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Detail | |
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criteria provided, single submitter | schizophrenia |
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Detail |
CIViC
[No Data.]
DisGeNET
Score | Disease name | Description | Source | Pubmed | Links |
---|---|---|---|---|---|
0.033 | breast carcinoma | Pairwise analysis showed that combinations of the ERalpha G allele with the homo... | BeFree | 18820009 | Detail |
0.345 | schizophrenia | Our results demonstrated initial significant associations of two SNPs for DRD2 (... | BeFree | 19207030 | Detail |
0.240 | Malignant neoplasm of breast | Pairwise analysis showed that combinations of the ERalpha G allele with the homo... | BeFree | 18820009 | Detail |
0.080 | breast carcinoma | Pairwise analysis showed that combinations of the ERalpha G allele with the homo... | BeFree | 18820009 | Detail |
<0.001 | Chronic Kidney Diseases | The Chi-square test, multivariable logistic regression analysis with adjustment ... | BeFree | 19578796 | Detail |
0.001 | Chronic Kidney Diseases | The Chi-square test, multivariable logistic regression analysis with adjustment ... | BeFree | 19578796 | Detail |
<0.001 | Chronic Kidney Diseases | The Chi-square test, multivariable logistic regression analysis with adjustment ... | BeFree | 19578796 | Detail |
0.127 | major depressive disorder | To investigate the possible relationship between genetic risk factors and depres... | BeFree | 23157339 | Detail |
0.082 | depressive disorder | To investigate the possible relationship between genetic risk factors and depres... | BeFree | 23157339 | Detail |
0.026 | Mental Depression | To investigate the possible relationship between genetic risk factors and depres... | BeFree | 23157339 | Detail |
0.002 | Unipolar Depression | To investigate the possible relationship between genetic risk factors and depres... | BeFree | 23157339 | Detail |
0.013 | Mental Depression | To investigate the possible relationship between genetic risk factors and depres... | BeFree | 23157339 | Detail |
0.006 | depressive disorder | To investigate the possible relationship between genetic risk factors and depres... | BeFree | 23157339 | Detail |
0.088 | depressive disorder | To investigate the possible relationship between genetic risk factors and depres... | BeFree | 23157339 | Detail |
0.018 | Mental Depression | To investigate the possible relationship between genetic risk factors and depres... | BeFree | 23157339 | Detail |
0.087 | depressive disorder | To investigate the possible relationship between genetic risk factors and depres... | BeFree | 23157339 | Detail |
0.002 | depressive disorder | To investigate the possible relationship between genetic risk factors and depres... | BeFree | 23157339 | Detail |
0.003 | major depressive disorder | To investigate the possible relationship between genetic risk factors and depres... | BeFree | 23157339 | Detail |
0.004 | Unipolar Depression | To investigate the possible relationship between genetic risk factors and depres... | BeFree | 23157339 | Detail |
0.020 | Mental Depression | To investigate the possible relationship between genetic risk factors and depres... | BeFree | 23157339 | Detail |
0.009 | depressive disorder | To investigate the possible relationship between genetic risk factors and depres... | BeFree | 23157339 | Detail |
0.033 | Mental Depression | To investigate the possible relationship between genetic risk factors and depres... | BeFree | 23157339 | Detail |
0.006 | depressive disorder | To investigate the possible relationship between genetic risk factors and depres... | BeFree | 23157339 | Detail |
0.038 | Mental Depression | To investigate the possible relationship between genetic risk factors and depres... | BeFree | 23157339 | Detail |
0.009 | Mental Depression | To investigate the possible relationship between genetic risk factors and depres... | BeFree | 23157339 | Detail |
0.043 | Mental Depression | To investigate the possible relationship between genetic risk factors and depres... | BeFree | 23157339 | Detail |
0.007 | depressive disorder | To investigate the possible relationship between genetic risk factors and depres... | BeFree | 23157339 | Detail |
0.020 | panic disorder | Nine gene-candidates, including 5-HTTLPR, MAO-A VNTR, TPH2 rs1386494, 5-HTR1A -1... | BeFree | 18832011 | Detail |
0.005 | PANIC DISORDER 1 | Nine gene-candidates, including 5-HTTLPR, MAO-A VNTR, TPH2 rs1386494, 5-HTR1A -1... | BeFree | 18832011 | Detail |
0.002 | PANIC DISORDER 1 | Nine gene-candidates, including 5-HTTLPR, MAO-A VNTR, TPH2 rs1386494, 5-HTR1A -1... | BeFree | 18832011 | Detail |
0.162 | panic disorder | Nine gene-candidates, including 5-HTTLPR, MAO-A VNTR, TPH2 rs1386494, 5-HTR1A -1... | BeFree | 18832011 | Detail |
0.178 | attention deficit hyperactivity disorder | We genotyped a sample of 45 adults with ADHD at four candidate polymorphisms for... | BeFree | 17886261 | Detail |
<0.001 | attention deficit hyperactivity disorder | We genotyped a sample of 45 adults with ADHD at four candidate polymorphisms for... | BeFree | 17886261 | Detail |
0.329 | attention deficit hyperactivity disorder | We genotyped a sample of 45 adults with ADHD at four candidate polymorphisms for... | BeFree | 17886261 | Detail |
0.340 | attention deficit hyperactivity disorder | We genotyped a sample of 45 adults with ADHD at four candidate polymorphisms for... | BeFree | 17886261 | Detail |
<0.001 | epilepsy | Stage 1 analysis included 290 patients with epilepsy and revealed a higher load ... | BeFree | 22881836 | Detail |
<0.001 | epilepsy | Stage 1 analysis included 290 patients with epilepsy and revealed a higher load ... | BeFree | 22881836 | Detail |
0.345 | schizophrenia | We find that P50 and PPI may be influenced by COMT rs4680 polymorphisms in schiz... | BeFree | 23598060 | Detail |
0.345 | schizophrenia | A common functional polymorphism, Val108/158Met (rs4680), and haplotypes rs73786... | BeFree | 19329282 | Detail |
0.012 | schizophrenia | We find that P50 and PPI may be influenced by COMT rs4680 polymorphisms in schiz... | BeFree | 23598060 | Detail |
<0.001 | Opiate Addiction | To determine whether COMT is important in substance dependence, rs165774 and rs4... | BeFree | 22208661 | Detail |
0.345 | schizophrenia | It is possible that the rs165774 SNP, in combination with rs4680, results in a c... | BeFree | 22208661 | Detail |
0.122 | DiGeorge syndrome | The increased volumes in the genu, splenium and total CC in the 22q11DS group we... | BeFree | 22763378 | Detail |
0.121 | Shprintzen syndrome | The increased volumes in the genu, splenium and total CC in the 22q11DS group we... | BeFree | 22763378 | Detail |
0.280 | DiGeorge syndrome | The increased volumes in the genu, splenium and total CC in the 22q11DS group we... | BeFree | 22763378 | Detail |
0.135 | Shprintzen syndrome | The increased volumes in the genu, splenium and total CC in the 22q11DS group we... | BeFree | 22763378 | Detail |
<0.001 | Shprintzen syndrome | The increased volumes in the genu, splenium and total CC in the 22q11DS group we... | BeFree | 22763378 | Detail |
<0.001 | DiGeorge syndrome | The increased volumes in the genu, splenium and total CC in the 22q11DS group we... | BeFree | 22763378 | Detail |
0.014 | endometrial carcinoma | Patients with EH (n = 89), EH concurrent with ECa (n = 76), ECa (n = 186), and h... | BeFree | 25741405 | Detail |
<0.001 | endometrial hyperplasia | Patients with EH (n = 89), EH concurrent with ECa (n = 76), ECa (n = 186), and h... | BeFree | 25741405 | Detail |
<0.001 | Flushing | Functional alleles that alter alcoholism-related intermediate phenotypes include... | BeFree | 15584875 | Detail |
0.011 | Flushing | Functional alleles that alter alcoholism-related intermediate phenotypes include... | BeFree | 15584875 | Detail |
<0.001 | Dysphoric mood | Functional alleles that alter alcoholism-related intermediate phenotypes include... | BeFree | 15584875 | Detail |
0.347 | Alcoholic Intoxication, Chronic | Functional alleles that alter alcoholism-related intermediate phenotypes include... | BeFree | 15584875 | Detail |
0.159 | Alcoholic Intoxication, Chronic | Functional alleles that alter alcoholism-related intermediate phenotypes include... | BeFree | 15584875 | Detail |
<0.001 | Dysphoric mood | Functional alleles that alter alcoholism-related intermediate phenotypes include... | BeFree | 15584875 | Detail |
0.001 | Anxiety Disorders | Functional alleles that alter alcoholism-related intermediate phenotypes include... | BeFree | 15584875 | Detail |
0.157 | Alcoholic Intoxication, Chronic | Functional alleles that alter alcoholism-related intermediate phenotypes include... | BeFree | 15584875 | Detail |
<0.001 | Anxiety Disorders | Functional alleles that alter alcoholism-related intermediate phenotypes include... | BeFree | 15584875 | Detail |
0.017 | Anxiety Disorders | Functional alleles that alter alcoholism-related intermediate phenotypes include... | BeFree | 15584875 | Detail |
0.001 | Nonorganic psychosis | Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) po... | BeFree | 18351593 | Detail |
<0.001 | Bulimia | We explored the influence of interactions between polymorphisms acting upon post... | BeFree | 22683321 | Detail |
0.004 | nicotine dependence | Age, gender, Fagerström Test for Nicotine Dependence, dopamine pathway genotypes... | BeFree | 23941313 | Detail |
<0.001 | Eating Disorders | We explored the influence of interactions between polymorphisms acting upon post... | BeFree | 22683321 | Detail |
<0.001 | Bulimia | We explored the influence of interactions between polymorphisms acting upon post... | BeFree | 22683321 | Detail |
0.003 | Bulimia | We explored the influence of interactions between polymorphisms acting upon post... | BeFree | 22683321 | Detail |
0.004 | Psychotic Disorders | Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) po... | BeFree | 18351593 | Detail |
0.001 | Eating Disorders | We explored the influence of interactions between polymorphisms acting upon post... | BeFree | 22683321 | Detail |
0.006 | Psychotic Disorders | Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) po... | BeFree | 18351593 | Detail |
0.006 | Eating Disorders | We explored the influence of interactions between polymorphisms acting upon post... | BeFree | 22683321 | Detail |
0.003 | Nonorganic psychosis | Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) po... | BeFree | 18351593 | Detail |
0.003 | Eating Disorders | We explored the influence of interactions between polymorphisms acting upon post... | BeFree | 22683321 | Detail |
0.003 | Bulimia | We explored the influence of interactions between polymorphisms acting upon post... | BeFree | 22683321 | Detail |
0.012 | Nonorganic psychosis | Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) po... | BeFree | 18351593 | Detail |
0.032 | Psychotic Disorders | Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) po... | BeFree | 18351593 | Detail |
0.003 | Impaired cognition | The investigation of the catechol-O-methyltransferase (COMT-[rs4680]) and methyl... | BeFree | 23353103 | Detail |
0.003 | Impaired cognition | The investigation of the catechol-O-methyltransferase (COMT-[rs4680]) and methyl... | BeFree | 23353103 | Detail |
<0.001 | adenocarcinoma | The G/G homozygous genotype in COMT rs4680 and A/A homozygous genotype in PLCH1 ... | BeFree | 22658813 | Detail |
<0.001 | squamous cell carcinoma | The G/G homozygous genotype in COMT rs4680 and A/A homozygous genotype in PLCH1 ... | BeFree | 22658813 | Detail |
0.101 | Malignant neoplasm of breast | However, when this relation was assessed within strata based on estrogen-related... | BeFree | 22199302 | Detail |
0.240 | Malignant neoplasm of breast | However, when this relation was assessed within strata based on estrogen-related... | BeFree | 22199302 | Detail |
0.028 | Malignant neoplasm of breast | However, when this relation was assessed within strata based on estrogen-related... | BeFree | 22199302 | Detail |
0.005 | Mammographic Density | However, when this relation was assessed within strata based on estrogen-related... | BeFree | 22199302 | Detail |
0.003 | Mammographic Density | However, when this relation was assessed within strata based on estrogen-related... | BeFree | 22199302 | Detail |
0.080 | breast carcinoma | However, when this relation was assessed within strata based on estrogen-related... | BeFree | 22199302 | Detail |
0.004 | breast carcinoma | However, when this relation was assessed within strata based on estrogen-related... | BeFree | 22199302 | Detail |
0.003 | Mammographic Density | However, when this relation was assessed within strata based on estrogen-related... | BeFree | 22199302 | Detail |
0.021 | breast carcinoma | However, when this relation was assessed within strata based on estrogen-related... | BeFree | 22199302 | Detail |
0.004 | breast carcinoma | However, when this relation was assessed within strata based on estrogen-related... | BeFree | 22199302 | Detail |
0.006 | Mammographic Density | However, when this relation was assessed within strata based on estrogen-related... | BeFree | 22199302 | Detail |
0.042 | Malignant neoplasm of breast | However, when this relation was assessed within strata based on estrogen-related... | BeFree | 22199302 | Detail |
0.097 | Malignant neoplasm of breast | We examined the potential association of breast cancer risk in Mexican women wit... | BeFree | 23000097 | Detail |
0.001 | Uterine Fibroids | The genetic polymorphism of rs3087869 (IVS1+2329C>T) (OR 3.200, 95% CI 1.614-... | BeFree | 24777039 | Detail |
0.104 | Malignant neoplasm of breast | We examined the potential association of breast cancer risk in Mexican women wit... | BeFree | 23000097 | Detail |
0.101 | Malignant neoplasm of breast | We examined the potential association of breast cancer risk in Mexican women wit... | BeFree | 23000097 | Detail |
0.102 | Malignant neoplasm of breast | We examined the potential association of breast cancer risk in Mexican women wit... | BeFree | 23000097 | Detail |
0.017 | breast carcinoma | We examined the potential association of breast cancer risk in Mexican women wit... | BeFree | 23000097 | Detail |
0.002 | Uterine Fibroids | The genetic polymorphism of rs3087869 (IVS1+2329C>T) (OR 3.200, 95% CI 1.614-... | BeFree | 24777039 | Detail |
0.021 | breast carcinoma | We examined the potential association of breast cancer risk in Mexican women wit... | BeFree | 23000097 | Detail |
0.001 | Uterine Fibroids | The genetic polymorphisms of IVS1+2329C>T and Val158Met loci in COMT, Ile462V... | BeFree | 24320736 | Detail |
0.002 | Uterine Fibroids | The genetic polymorphisms of IVS1+2329C>T and Val158Met loci in COMT, Ile462V... | BeFree | 24320736 | Detail |
0.016 | breast carcinoma | We examined the potential association of breast cancer risk in Mexican women wit... | BeFree | 23000097 | Detail |
0.096 | Malignant neoplasm of breast | We examined the potential association of breast cancer risk in Mexican women wit... | BeFree | 23000097 | Detail |
0.024 | breast carcinoma | We examined the potential association of breast cancer risk in Mexican women wit... | BeFree | 23000097 | Detail |
0.004 | Uterine Fibroids | The genetic polymorphism of rs3087869 (IVS1+2329C>T) (OR 3.200, 95% CI 1.614-... | BeFree | 24777039 | Detail |
0.019 | breast carcinoma | We examined the potential association of breast cancer risk in Mexican women wit... | BeFree | 23000097 | Detail |
0.099 | Malignant neoplasm of breast | We examined the potential association of breast cancer risk in Mexican women wit... | BeFree | 23000097 | Detail |
0.022 | breast carcinoma | We examined the potential association of breast cancer risk in Mexican women wit... | BeFree | 23000097 | Detail |
0.004 | Uterine Fibroids | The genetic polymorphisms of IVS1+2329C>T and Val158Met loci in COMT, Ile462V... | BeFree | 24320736 | Detail |
0.345 | schizophrenia | We assessed catechol-O-methyltransferase (COMT) Val108/158Met (rs4680) and dopam... | BeFree | 24495967 | Detail |
0.291 | schizophrenia | We assessed catechol-O-methyltransferase (COMT) Val108/158Met (rs4680) and dopam... | BeFree | 24495967 | Detail |
0.007 | Marijuana Abuse | Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms ... | BeFree | 24407958 | Detail |
0.014 | Marijuana Abuse | Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms ... | BeFree | 24407958 | Detail |
<0.001 | Marijuana Abuse | Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms ... | BeFree | 24407958 | Detail |
0.002 | Marijuana Abuse | Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms ... | BeFree | 24407958 | Detail |
0.006 | Marijuana Abuse | Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms ... | BeFree | 24407958 | Detail |
0.003 | Marijuana Abuse | Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms ... | BeFree | 24407958 | Detail |
0.120 | Mental Depression | Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158... | BeFree | 17941097 | Detail |
0.002 | Chronic pain | However, genetic effects (COMT Val(158)Met and BDNF Val(66)Met) on experimental ... | BeFree | 21049025 | Detail |
0.009 | depressive disorder | Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158... | BeFree | 17941097 | Detail |
0.017 | Anxiety Disorders | Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxi... | BeFree | 19582565 | Detail |
0.248 | depressive disorder | Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158... | BeFree | 17941097 | Detail |
0.001 | Autism Spectrum Disorders | Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxi... | BeFree | 19582565 | Detail |
0.038 | Mental Depression | Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158... | BeFree | 17941097 | Detail |
0.006 | Cognitive changes | Patients were also genotyped for three polymorphisms associated with cognitive c... | BeFree | 25080285 | Detail |
<0.001 | Cognitive changes | Patients were also genotyped for three polymorphisms associated with cognitive c... | BeFree | 25080285 | Detail |
<0.001 | Cognitive changes | Patients were also genotyped for three polymorphisms associated with cognitive c... | BeFree | 25080285 | Detail |
0.104 | Malignant neoplasm of breast | Results from this study suggest that rs4680 in the COMT gene and rs4646903 in th... | BeFree | 17429315 | Detail |
0.024 | breast carcinoma | Results from this study suggest that rs4680 in the COMT gene and rs4646903 in th... | BeFree | 17429315 | Detail |
0.101 | Malignant neoplasm of breast | Results from this study suggest that rs4680 in the COMT gene and rs4646903 in th... | BeFree | 17429315 | Detail |
0.021 | breast carcinoma | Results from this study suggest that rs4680 in the COMT gene and rs4646903 in th... | BeFree | 17429315 | Detail |
<0.001 | Phobic anxiety disorder | Functional polymorphisms in the MAO-A uVNTR promoter gene, the COMT gene (Val158... | BeFree | 15450911 | Detail |
0.023 | fibromyalgia | Catechol-O-methyltransferase Val158Met polymorphism influences anxiety, depressi... | BeFree | 23025981 | Detail |
0.124 | 22q11 Deletion Syndrome | COMT Val(158) met genotype and striatal D(2/3) receptor binding in adults with 2... | BeFree | 21465565 | Detail |
0.001 | post-traumatic stress disorder | Catechol-O-methyltransferase Val158Met polymorphism moderates anterior cingulate... | BeFree | 21783175 | Detail |
0.034 | obsessive-compulsive disorder | Many of these differences are unconfirmed or minor, but some appear to be of rea... | BeFree | 17805313 | Detail |
0.162 | panic disorder | Only Val158Met polymorphism of the catechol-O-methyltransferase gene has been im... | BeFree | 20048750 | Detail |
0.124 | Anxiety Disorders | The paper focuses on such candidate gene polymorphisms that alter alcoholism-rel... | BeFree | 17079080 | Detail |
0.016 | major depressive disorder | We investigated the associations between COMT Val(158)Met and depression in a Sw... | BeFree | 20828831 | Detail |
0.032 | Psychotic Disorders | In addition, carriers of the COMT Val(158)Met Val allele were more susceptible t... | BeFree | 17640440 | Detail |
0.005 | PANIC DISORDER 1 | Sympathetic nervous function and the effect of the catechol-O-methyltransferase ... | BeFree | 19900710 | Detail |
0.002 | Uterine Fibroids | The associations between the Val158Met in the catechol-O-methyltransferase (COMT... | BeFree | 23939469 | Detail |
<0.001 | female breast carcinoma | We examined 87 cases and 341 population controls in Taiwan to determine the asso... | BeFree | 16191465 | Detail |
0.009 | depressive disorder | The functional Val158Met polymorphism in catechol-O-methyltransferase (COMT) is ... | BeFree | 20828831 | Detail |
0.157 | Alcoholic Intoxication, Chronic | Reduced dopamine receptor sensitivity as an intermediate phenotype in alcohol de... | BeFree | 22474103 | Detail |
0.082 | attention deficit hyperactivity disorder | We studied the association of the catechol O-methyltransferase (COMT) Val158Met ... | BeFree | 20868372 | Detail |
0.032 | Psychotic Disorders | Our review examined evidence of an association between the COMT Val(158)Met poly... | BeFree | 23527885 | Detail |
0.345 | schizophrenia | No association found between 158 Val/Met polymorphism of the COMT gene and schiz... | BeFree | 16109444 | Detail |
0.345 | schizophrenia | Cannabis use profiles and COMT Val158Met genotypes were obtained from 80 inpatie... | BeFree | 21231925 | Detail |
0.280 | DiGeorge syndrome | [The effects of gender and catechol O-methyltransferase (COMT) Val108/158Met pol... | GAD | 20123031 | Detail |
<0.001 | Drug withdrawal syndrome | Our results indicate that genotyping for COMT rs4680 and SLC6A4 STin2 VNTR could... | BeFree | 24684248 | Detail |
0.019 | lingual-facial-buccal dyskinesia | Evidence from pooled data for genetic association with tardive dyskinesia (TD) s... | BeFree | 18180754 | Detail |
0.017 | Anxiety Disorders | Association of the catechol-O-methyltransferase val158met polymorphism and anxie... | BeFree | 24300663 | Detail |
0.181 | bipolar disorder | This work first showed the association of combined Leu136Leu and Val158Met varia... | BeFree | 25766270 | Detail |
0.002 | nicotine dependence | The catechol-O-methyltransferase (COMT) Val158Met polymorphism may be a risk fac... | BeFree | 23459442 | Detail |
0.023 | fibromyalgia | Clinical symptoms in fibromyalgia are associated to catechol-O-methyltransferase... | BeFree | 24762091 | Detail |
0.345 | schizophrenia | Catechol-O-methyltransferase Val158Met polymorphism in relation to aggressive sc... | BeFree | 18789857 | Detail |
<0.001 | Drug withdrawal syndrome | Our results indicate that genotyping for COMT rs4680 and SLC6A4 STin2 VNTR could... | BeFree | 24684248 | Detail |
0.002 | nicotine dependence | The common methionine (met) for valine (val) at codon 158 (val(158)met) polymorp... | BeFree | 23828159 | Detail |
0.345 | schizophrenia | No association between the Catechol-O-Methyltransferase (COMT) val158met polymor... | BeFree | 21458532 | Detail |
0.345 | schizophrenia | Interaction between catechol-O-methyltransferase (COMT) Val158Met genotype and g... | BeFree | 22617427 | Detail |
0.034 | obsessive-compulsive disorder | In subjects of Afrikaner descent, the L/L genotype of the COMT Val158Met polymor... | BeFree | 16187774 | Detail |
0.003 | Herpes Simplex Infections | Both the COMT Val158Met polymorphism and serological evidence of HSV-1 infection... | BeFree | 16542182 | Detail |
0.003 | schizophrenia | Here, we report the investigation of the differential activity of membrane-bound... | BeFree | 16984965 | Detail |
0.002 | Unipolar Depression | Dopamine 2 receptor gene (DRD2) polymorphism C957T (rs6277) and cathechol-o-meth... | BeFree | 18929622 | Detail |
0.012 | Nonorganic psychosis | Carriers of the COMT Val(158)Met Val allele, but not subjects with the Met/Met g... | BeFree | 18808401 | Detail |
<0.001 | Mental disorders | Polymorphisms of COMT Val158Met and DAT1 3'-UTR VNTR in illicit drug use and dru... | BeFree | 24708432 | Detail |
0.021 | breast carcinoma | Association of COMT Val158Met polymorphism and breast cancer risk: an updated me... | BeFree | 23039364 | Detail |
0.345 | schizophrenia | Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical fun... | BeFree | 19666577 | Detail |
0.058 | Malignant neoplasm of prostate | The Val158Met polymorphism of the catechol-O-methyltransferase gene is associate... | BeFree | 16126332 | Detail |
0.058 | Malignant neoplasm of prostate | The Val158Met polymorphism of the catechol-O-methyltransferase gene is associate... | BeFree | 16126332 | Detail |
0.012 | Nonorganic psychosis | Cannabis use and age at onset of psychosis: further evidence of interaction with... | BeFree | 21231925 | Detail |
0.017 | Anxiety Disorders | The present results provide further support for a-potentially female-specific-ro... | BeFree | 22387174 | Detail |
0.001 | post-traumatic stress disorder | The risk of posttraumatic stress disorder after trauma depends on traumatic load... | BeFree | 19944409 | Detail |
0.012 | Nonorganic psychosis | The aim of the study was to evaluate the influence of COMT Val158Met polymorphis... | BeFree | 18092319 | Detail |
0.005 | osteochondritis dissecans | These results do not support the hypothesis that the COMT Val158Met gene polymor... | BeFree | 16043283 | Detail |
0.162 | panic disorder | Gender-specific association between the COMT Val158Met polymorphism and openness... | BeFree | 24852514 | Detail |
0.002 | borderline personality disorder | The catechol o-methyltransferase (COMT) val(158)met polymorphism modulates the a... | BeFree | 19906087 | Detail |
<0.001 | Chronic tension-type headache | Genetic contribution of catechol-O-methyltransferase polymorphism (Val158Met) in... | BeFree | 21691248 | Detail |
0.017 | Anxiety Disorders | A coding variant in one such gene, encoding the dopamine catabolic enzyme catech... | BeFree | 18729643 | Detail |
0.157 | Alcoholic Intoxication, Chronic | [We evaluated the association of COMT genotype at this locus with blood pressure... | GAD | 19023276 | Detail |
0.004 | MAJOR AFFECTIVE DISORDER 8 | Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han C... | BeFree | 9352569 | Detail |
0.264 | Anxiety Disorders | The paper focuses on such candidate gene polymorphisms that alter alcoholism-rel... | BeFree | 17079080 | Detail |
0.016 | major depressive disorder | Association of the COMT val158met variant with antidepressant treatment response... | BeFree | 17522626 | Detail |
0.181 | bipolar disorder | The impact of the Val158Met catechol-O-methyltransferase genotype on neural corr... | BeFree | 20667170 | Detail |
0.034 | obsessive-compulsive disorder | The data here are consistent with previous work delineating the different sympto... | BeFree | 19398820 | Detail |
0.002 | Malignant neoplasm of endometrium | Contribution of catechol-O-methyltransferase Val158Met polymorphism to endometri... | BeFree | 24390993 | Detail |
<0.001 | Apathy | Our study indicates an association between rs4680, an SNP in the COMT gene, and ... | BeFree | 23769684 | Detail |
0.012 | Nonorganic psychosis | A putative interaction between cannabis and variation at rs4680 within the catec... | BeFree | 21947654 | Detail |
0.001 | Memory impairment | The COMT val(158)met polymorphism was associated with abstinence-related working... | BeFree | 23828159 | Detail |
0.003 | Hot flushes | Compared with nonsmokers, European-American COMT Val158Met double-variant carrie... | BeFree | 22466345 | Detail |
0.093 | Hypertensive disease | Previous studies of a functional variant of the catechol-O-methyl transferase (C... | BeFree | 21776034 | Detail |
0.345 | schizophrenia | Effect of catechol O-methyltransferase val(158)met polymorphism on the p50 gatin... | BeFree | 17448448 | Detail |
0.001 | irritable bowel syndrome | Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in i... | BeFree | 23110189 | Detail |
0.008 | Unipolar Depression | Association of the COMT val158met variant with antidepressant treatment response... | BeFree | 17522626 | Detail |
0.014 | Marijuana Abuse | Catechol-O-Methyltransferase (COMT) Val158Met variations and cannabis use in fir... | BeFree | 20493536 | Detail |
0.157 | Alcoholic Intoxication, Chronic | COMT Val158Met modulates the effect of childhood adverse experiences on the risk... | BeFree | 22509987 | Detail |
0.178 | attention deficit hyperactivity disorder | This study aimed to derive a comprehensive, whole-brain characterization of larg... | BeFree | 25201318 | Detail |
0.345 | schizophrenia | COMT Val 158 Met polymorphism is associated with cognitive flexibility in a sign... | BeFree | 19585392 | Detail |
0.004 | Carcinogenesis | To better evaluate the role of COMT Val158Met in endometrial carcinogenesis, we ... | BeFree | 24390993 | Detail |
0.345 | schizophrenia | Moreover, variations in the COMT Val158Met functional polymorphism have been ass... | BeFree | 18407467 | Detail |
0.014 | Mood Disorders | Association of the COMT synonymous polymorphism Leu136Leu and missense variant V... | BeFree | 25766270 | Detail |
<0.001 | Obesity, Abdominal | Catechol O-methyltransferase val158-met polymorphism is associated with abdomina... | BeFree | 18442637 | Detail |
<0.001 | Delusions | We sought to determine whether the COMT val158met polymorphism (rs4680) is assoc... | BeFree | 23069674 | Detail |
<0.001 | Phobic anxiety disorder | Functional polymorphisms in the MAO-A uVNTR promoter gene, the COMT gene (Val158... | BeFree | 15450911 | Detail |
0.204 | Alcoholic Intoxication, Chronic | This study tested the hypothesis that genetic variation in COMT Val158Met and DR... | BeFree | 22509987 | Detail |
0.345 | schizophrenia | Association study of catechol-O-methyltransferase (COMT) gene Val158Met polymorp... | BeFree | 20483173 | Detail |
<0.001 | homicidal | The purpose of our study is to examine the association between Ala72Ser and Val1... | BeFree | 18163386 | Detail |
0.009 | depressive disorder | In the present study, 256 patients with major depression (DSM-IV) of Caucasian d... | BeFree | 17522626 | Detail |
0.345 | schizophrenia | Executive subprocesses in working memory: relationship to catechol-O-methyltrans... | BeFree | 12963670 | Detail |
<0.001 | Anemia, Sickle Cell | Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorp... | BeFree | 25102390 | Detail |
0.345 | schizophrenia | Catechol-O-methyltransferase Val158Met polymorphism in schizophrenia: associatio... | BeFree | 16037677 | Detail |
0.004 | Dyskinetic syndrome | Catechol-O-methyltransferase Val158Met and the risk of dyskinesias in Parkinson'... | BeFree | 22083803 | Detail |
0.004 | MAJOR AFFECTIVE DISORDER 6 | Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han C... | BeFree | 9352569 | Detail |
0.032 | Psychotic Disorders | The Val158Met polymorphism of the COMT (Catechol-O-Methyltransferase) gene, invo... | BeFree | 20493536 | Detail |
<0.001 | Aggressive personality | A functional single nucleotide polymorphism (V158M) in the COMT gene is associat... | BeFree | 12842306 | Detail |
0.032 | Psychotic Disorders | Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond. | BeFree | 16476412 | Detail |
0.021 | Malignant neoplasm of prostate | A total of 11 htSNPs (including COMT Val(158)Met) were selected based on the res... | BeFree | 17018638 | Detail |
0.005 | PANIC DISORDER 1 | Association between the catechol-O-methyltransferase Val158Met polymorphism and ... | BeFree | 20457471 | Detail |
0.345 | schizophrenia | Associations between COMT Val(158)Met genotype and RTV do not appear to reflect ... | BeFree | 16815691 | Detail |
0.005 | Depression, Postpartum | Among those with history of psychiatric problems, the COMT-Val158Met and 5HTT-LP... | BeFree | 21099450 | Detail |
0.345 | schizophrenia | Catechol-O-methyltransferase Val(158)Met association with parahippocampal physio... | BeFree | 21144115 | Detail |
0.005 | PANIC DISORDER 1 | Influence of the catechol-O-methyltransferase val158met genotype on amygdala and... | BeFree | 18440204 | Detail |
0.003 | adenocarcinoma | In this study, we found that the COMT rs4680 SNP was significantly associated wi... | BeFree | 22658813 | Detail |
<0.001 | Sciatica | We examined if the COMT Val158Met SNP could contribute to discogenic subacute lo... | BeFree | 22337560 | Detail |
0.219 | schizophrenia | A functional interaction between Catechol-O-Methyltransferase (COMT) Val158Met a... | BeFree | 22128864 | Detail |
0.178 | attention deficit hyperactivity disorder | Catechol-O-methyltransferase valine158methionine polymorphism moderates methylph... | BeFree | 21550019 | Detail |
0.023 | fibromyalgia | These results suggest that SNPs rs4680 and rs4818 of the COMT gene may be associ... | BeFree | 21120493 | Detail |
<0.001 | Psychoses, Drug | To investigate the involvement of COMT Val158Met and DAT1 3'-UTR VNTR genotypes ... | BeFree | 24708432 | Detail |
0.345 | schizophrenia | Heterozygosity at catechol-O-methyltransferase Val158Met and schizophrenia: new ... | BeFree | 20488458 | Detail |
0.132 | Mental disorders | The Val158Met polymorphism of the gene encoding catechol-O-methyltransferase (CO... | BeFree | 18384078 | Detail |
<0.001 | Psychoses, Drug | To investigate the involvement of COMT Val158Met and DAT1 3'-UTR VNTR genotypes ... | BeFree | 24708432 | Detail |
<0.001 | Mild cognitive disorder | The aim of this study is to examine the influence of the catechol-O-methyltranfe... | BeFree | 19793392 | Detail |
0.181 | bipolar disorder | This is the first study suggesting that COMT rs4680 modulates FER differently du... | BeFree | 22222175 | Detail |
0.012 | Nonorganic psychosis | COMT Val158Met-stress interaction in psychosis: role of background psychosis ris... | BeFree | 21073668 | Detail |
<0.001 | carpal tunnel syndrome | Catechol-O-methyltransferase Val158Met polymorphism is associated with pain and ... | BeFree | 24077209 | Detail |
0.038 | Mental Depression | The present study investigated the effects of familial risk for depression and t... | BeFree | 24679392 | Detail |
<0.001 | Acute onset pain | Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorp... | BeFree | 25102390 | Detail |
0.005 | prostate carcinoma | The Val158Met polymorphism of the catechol-O-methyltransferase gene is associate... | BeFree | 16126332 | Detail |
0.001 | conduct disorder | Variation in the catechol-O-methyltransferase Val 158 Met polymorphism associate... | BeFree | 19997043 | Detail |
0.023 | bipolar disorder | Functional polymorphisms in the serotonin transporter (5-HTTLPR), catechol-O-met... | BeFree | 16969276 | Detail |
0.345 | schizophrenia | Anhedonia as a phenotype for the Val158Met COMT polymorphism in relatives of pat... | BeFree | 19025226 | Detail |
0.017 | Anxiety Disorders | We show that Val/Val but neither Met/Met nor Val/Met carriers of the catechol-O-... | BeFree | 25238960 | Detail |
0.004 | MAJOR AFFECTIVE DISORDER 2 | Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han C... | BeFree | 9352569 | Detail |
0.101 | Malignant neoplasm of breast | Catechol-O-methyltransferase Val158Met polymorphism and breast cancer risk in As... | BeFree | 24146281 | Detail |
0.002 | Unipolar Depression | Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical o... | BeFree | 24555772 | Detail |
<0.001 | bulimia nervosa | Previous studies have shown that the met allele of the COMT val158met single nuc... | BeFree | 25216558 | Detail |
0.012 | schizophrenia | Effect of catechol O-methyltransferase val(158)met polymorphism on the p50 gatin... | BeFree | 17448448 | Detail |
<0.001 | Coronary Arteriosclerosis | Functional COMT Val158Met polymorphism, risk of acute coronary events and serum ... | BeFree | 17264883 | Detail |
0.016 | major depressive disorder | Effect of the COMT val158met polymorphism on white matter connectivity in patien... | BeFree | 23618651 | Detail |
0.058 | prostate carcinoma | The Val158Met polymorphism of the catechol-O-methyltransferase gene is associate... | BeFree | 16126332 | Detail |
0.007 | major depressive disorder | Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical o... | BeFree | 24555772 | Detail |
0.012 | Nonorganic psychosis | Stress reactivity associated with COMT Val158Met in patients with psychosis may ... | BeFree | 22128864 | Detail |
<0.001 | Malignant neoplasm of female breast | We examined 87 cases and 341 population controls in Taiwan to determine the asso... | BeFree | 16191465 | Detail |
0.021 | breast carcinoma | Catechol-O-methyltransferase Val158Met polymorphism and breast cancer risk in As... | BeFree | 24146281 | Detail |
0.004 | lingual-facial-buccal dyskinesia | Negative association between catechol-O-methyltransferase (COMT) gene Val158Met ... | BeFree | 15583953 | Detail |
0.008 | Unipolar Depression | We investigated the associations between COMT Val(158)Met and depression in a Sw... | BeFree | 20828831 | Detail |
<0.001 | Mental Depression | Changes in severity of depression were assessed with weekly Hamilton Depression ... | BeFree | 20619611 | Detail |
0.178 | attention deficit hyperactivity disorder | No evidence of association between Catechol-O-Methyltransferase (COMT) Val158Met... | BeFree | 15182372 | Detail |
<0.001 | Breast Cancer, Familial | This case control study investigated whether polymorphisms of estrogen metaboliz... | BeFree | 19863350 | Detail |
0.058 | Malignant neoplasm of prostate | The Val158Met polymorphism of the catechol-O-methyltransferase gene is associate... | BeFree | 16126332 | Detail |
0.012 | Nonorganic psychosis | Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior i... | BeFree | 23799032 | Detail |
<0.001 | Drug usage | To investigate the involvement of COMT Val158Met and DAT1 3'-UTR VNTR genotypes ... | BeFree | 24708432 | Detail |
0.001 | Mixed anxiety and depressive disorder | Catechol-O-methyltransferase Val158Met polymorphism influences anxiety, depressi... | BeFree | 23025981 | Detail |
0.034 | obsessive-compulsive disorder | COMT Val158Met polymorphism in schizophrenia with obsessive-compulsive disorder:... | BeFree | 16043283 | Detail |
0.178 | attention deficit hyperactivity disorder | Catechol-O-methyltransferase (COMT; Val158Met) and DA D4-receptor (DRD4; 48 bp V... | BeFree | 22617852 | Detail |
0.001 | Mixed anxiety and depressive disorder | We investigated the associations between COMT Val(158)Met and depression in a Sw... | BeFree | 20828831 | Detail |
0.345 | schizophrenia | Opposite effects of catechol-O-methyltransferase Val158Met on cortical function ... | BeFree | 19054502 | Detail |
0.345 | schizophrenia | Based on the pivotal role ascribed to the prefrontal executive control network f... | BeFree | 15965969 | Detail |
0.282 | depressive disorder | The present study investigated the effects of familial risk for depression and t... | BeFree | 24679392 | Detail |
0.345 | schizophrenia | COMT Val158Met polymorphism in relation to activation and de-activation in the p... | BeFree | 20398774 | Detail |
0.155 | Mental Depression | The present study investigated the effects of familial risk for depression and t... | BeFree | 24679392 | Detail |
0.021 | breast carcinoma | Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatig... | BeFree | 21898113 | Detail |
0.017 | Anxiety Disorders | The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been found to... | BeFree | 19944409 | Detail |
0.021 | breast carcinoma | Association between the COMT Val158Met polymorphism and breast cancer risk: a me... | BeFree | 22297695 | Detail |
0.345 | schizophrenia | Prefrontal dysfunction in schizophrenia controlling for COMT Val158Met genotype ... | BeFree | 16952445 | Detail |
0.008 | Unipolar Depression | Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical o... | BeFree | 24555772 | Detail |
0.012 | Nonorganic psychosis | An experimental study of catechol-o-methyltransferase Val158Met moderation of de... | BeFree | 16936704 | Detail |
<0.001 | schizophrenia | COMT Val(158)Met polymorphism was studied with ARMS-PCR method in 99 outpatients... | BeFree | 20570494 | Detail |
0.004 | Carcinogenesis | Genetic polymorphism Val158Met of catechol-O-methyltransferase (COMT) may contri... | BeFree | 20591221 | Detail |
0.178 | attention deficit hyperactivity disorder | Catechol-O-methyltransferase Val158Met polymorphism is associated with methylphe... | BeFree | 18214865 | Detail |
<0.001 | bipolar disorder | Here, we report the investigation of the differential activity of membrane-bound... | BeFree | 16984965 | Detail |
0.178 | attention deficit hyperactivity disorder | COMT Val158Met variant and functional haplotypes associated with childhood ADHD ... | BeFree | 21300128 | Detail |
0.017 | Anxiety Disorders | We also found a significant interaction effect of COMT met alleles (β = -32.5 SE... | BeFree | 25722948 | Detail |
0.038 | Mental Depression | The Met allele of the Catechol-O-Methyltransferase (COMT) gene functional polymo... | BeFree | 18828035 | Detail |
0.181 | bipolar disorder | The catechol O-methyltransferase Val158Met polymorphism and herpes simplex virus... | BeFree | 16542182 | Detail |
0.010 | lingual-facial-buccal dyskinesia | Evidence from pooled data for genetic association with tardive dyskinesia (TD) s... | BeFree | 18180754 | Detail |
0.012 | Nonorganic psychosis | Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond. | BeFree | 16476412 | Detail |
<0.001 | spina bifida | The COMT rs4680 A allele was negatively related with the risk of spina bifida, w... | BeFree | 24382678 | Detail |
<0.001 | cocaine dependence | Association between the catechol-O-methyltransferase Val158Met polymorphism and ... | BeFree | 18704099 | Detail |
0.021 | breast carcinoma | Val158Met Polymorphism in catechol-O-methyltransferase gene associated with risk... | BeFree | 14504192 | Detail |
<0.001 | Malignant tumor of colon | Therefore, we evaluated the following ten estrogen metabolism-associated single-... | BeFree | 16202920 | Detail |
<0.001 | Mild cognitive disorder | Influence of COMT Val158Met polymorphism on Alzheimer's disease and mild cogniti... | BeFree | 22890094 | Detail |
0.021 | breast carcinoma | COMT Val158Met polymorphism and breast cancer risk: evidence from 26 case-contro... | BeFree | 20130981 | Detail |
0.014 | Mood Disorders | Results indicate a main as well as a GxE effect of the COMT Val158Met variant an... | BeFree | 22745815 | Detail |
0.005 | PANIC DISORDER 1 | Only Val158Met polymorphism of the catechol-O-methyltransferase gene has been im... | BeFree | 20048750 | Detail |
0.003 | Depression, Postpartum | Among those with history of psychiatric problems, the COMT-Val158Met and 5HTT-LP... | BeFree | 21099450 | Detail |
0.345 | schizophrenia | Catechol-O-methyltransferase Val 158 Met polymorphism and antisaccade eye moveme... | BeFree | 18562342 | Detail |
0.032 | Psychotic Disorders | An experimental study of catechol-o-methyltransferase Val158Met moderation of de... | BeFree | 16936704 | Detail |
0.101 | Malignant neoplasm of breast | Influence of catechol-o-methyltransferase genotype (Val158Met) on endocrine, sym... | BeFree | 21974969 | Detail |
0.124 | 22q11 Deletion Syndrome | No evidence for an effect of COMT Val158Met genotype on executive function in pa... | BeFree | 16513880 | Detail |
0.058 | prostate carcinoma | The Val158Met polymorphism of the catechol-O-methyltransferase gene is associate... | BeFree | 16126332 | Detail |
0.003 | Phobic anxiety disorder | Functional polymorphisms in the MAO-A uVNTR promoter gene, the COMT gene (Val158... | BeFree | 15450911 | Detail |
0.032 | Psychotic Disorders | Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior i... | BeFree | 23799032 | Detail |
0.017 | Anxiety Disorders | Depression and anxiety in relation to catechol-O-methyltransferase Val158Met gen... | BeFree | 18578865 | Detail |
0.017 | Anxiety Disorders | Given that catechol-O-methyltransferase (COMT) is widely distributed in the hipp... | BeFree | 25598522 | Detail |
0.004 | Carcinogenesis | Val158Met is a common single-nucleotide polymorphism of the COMT gene (Ex4-12 G&... | BeFree | 17636223 | Detail |
0.126 | Anxiety Disorders | The paper focuses on such candidate gene polymorphisms that alter alcoholism-rel... | BeFree | 17079080 | Detail |
0.101 | Malignant neoplasm of breast | When MnSOD Ala was combined with either cytochrome P450 1B1 CYP1B1*1 and catecho... | BeFree | 15386537 | Detail |
0.017 | Anxiety Disorders | A functional polymorphism of the COMT gene, val158met, has been linked to intern... | BeFree | 23475824 | Detail |
0.023 | fibromyalgia | The relationship between a common catechol-O-methyltransferase (COMT) polymorphi... | BeFree | 20074440 | Detail |
0.017 | Anxiety Disorders | This study suggests that the Val158Met COMT polymorphism modulated some psycholo... | BeFree | 23025981 | Detail |
0.204 | Alcoholic Intoxication, Chronic | COMT Val158Met and DRD2 Taq1A may confer their risk of alcohol dependence throug... | BeFree | 22474103 | Detail |
<0.001 | Malignant neoplasm of female breast | We examined 87 cases and 341 population controls in Taiwan to determine the asso... | BeFree | 16191465 | Detail |
0.032 | Psychotic Disorders | Cannabis use and age at onset of psychosis: further evidence of interaction with... | BeFree | 21231925 | Detail |
0.021 | breast carcinoma | A functional Val158Met polymorphism in the COMT gene has been known as a suscept... | BeFree | 17047485 | Detail |
0.236 | Pain | Given that catechol-O-methyltransferase (COMT) is widely distributed in the hipp... | BeFree | 25598522 | Detail |
<0.001 | Psychotic Disorders | Experimental effects of Delta-9-THC on cognition and psychosis are moderated by ... | BeFree | 16936704 | Detail |
0.006 | Mammographic Density | In a cross-sectional study of 396 Caucasian and African-American women, we evalu... | BeFree | 12052257 | Detail |
0.003 | oppositional defiant disorder | COMT Val(158)Met polymorphism has been associated with both symptoms of attentio... | BeFree | 22270685 | Detail |
<0.001 | desquamative interstitial pneumonia | However, neither allele frequencies of COMT Val158Met nor allele frequencies of ... | BeFree | 24708432 | Detail |
0.058 | Parkinson disease | Association of COMT Val158Met polymorphism with wearing-off susceptibility in Pa... | BeFree | 25367407 | Detail |
<0.001 | Anxiety state | A well-characterized single nucleotide polymorphism (472G/A-Val/Met-SNP8) in the... | BeFree | 11950461 | Detail |
0.345 | schizophrenia | The findings provide independent support for the hypothesis that the catechol-O-... | BeFree | 12372660 | Detail |
0.101 | Malignant neoplasm of breast | A functional Val158Met polymorphism in the COMT gene has been known as a suscept... | BeFree | 17047485 | Detail |
0.005 | PANIC DISORDER 1 | Meta-analysis of COMT val158met in panic disorder: ethnic heterogeneity and gend... | BeFree | 17357147 | Detail |
0.058 | Parkinson disease | Val158Met polymorphism of COMT gene and Parkinson's disease risk in Asians. | BeFree | 25060648 | Detail |
0.016 | major depressive disorder | The val158met polymorphism of the COMT gene exemplifies the lack of consensus in... | BeFree | 20558238 | Detail |
0.032 | Psychotic Disorders | A putative interaction between cannabis and variation at rs4680 within the catec... | BeFree | 21947654 | Detail |
0.010 | Tardive Dyskinesia | Evidence from pooled data for genetic association with tardive dyskinesia (TD) s... | BeFree | 18180754 | Detail |
<0.001 | colon carcinoma | Therefore, we evaluated the following ten estrogen metabolism-associated single-... | BeFree | 16202920 | Detail |
0.345 | schizophrenia | Genetic association of catechol-O-methyltransferase val(158)met polymorphism in ... | BeFree | 24782165 | Detail |
0.004 | Major affective disorder 7 | Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han C... | BeFree | 9352569 | Detail |
0.003 | myocardial infarction | The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism,... | BeFree | 17577421 | Detail |
0.014 | Mood Disorders | No association of COMT Val158Met polymorphism with suicidal behavior or CSF mono... | BeFree | 18828035 | Detail |
0.005 | osteochondritis dissecans | The data here are consistent with previous work delineating the different sympto... | BeFree | 19398820 | Detail |
0.003 | Psychotic symptom | The findings suggest that the COMT(Val158Met) polymorphism moderates affective a... | BeFree | 17525974 | Detail |
0.345 | schizophrenia | The C957T polymorphism in the dopamine D2 receptor (DRD2) gene and the Val158Met... | BeFree | 17113268 | Detail |
0.040 | Mild cognitive disorder | The aim of this study is to examine the influence of the catechol-O-methyltranfe... | BeFree | 19793392 | Detail |
<0.001 | bulimia nervosa | COMT Val158Met variant and functional haplotypes associated with childhood ADHD ... | BeFree | 21300128 | Detail |
0.181 | bipolar disorder | The aim of this study is to examine the role of the COMT gene Val158Met polymorp... | BeFree | 20004480 | Detail |
0.021 | breast carcinoma | When MnSOD Ala was combined with either cytochrome P450 1B1 CYP1B1*1 and catecho... | BeFree | 15386537 | Detail |
0.101 | Malignant neoplasm of breast | COMT rs4680 genotypes did not have a modifying effect on the association of gree... | BeFree | 19074205 | Detail |
0.058 | Parkinson disease | Catechol-O-methyltransferase Val158Met polymorphism: modulation of wearing-off s... | BeFree | 25108642 | Detail |
0.345 | schizophrenia | A meta-analysis of the Val158Met COMT polymorphism and violent behavior in schiz... | BeFree | 22905266 | Detail |
0.005 | PANIC DISORDER 1 | The effects of the catechol-O-methyltransferase val158met polymorphism on white ... | BeFree | 23141115 | Detail |
0.008 | Unipolar Depression | The val158met polymorphism of the COMT gene exemplifies the lack of consensus in... | BeFree | 20558238 | Detail |
0.002 | Tardive Dyskinesia | Negative association between catechol-O-methyltransferase (COMT) gene Val158Met ... | BeFree | 15583953 | Detail |
0.008 | Unipolar Depression | COMT val158met influence on electroconvulsive therapy response in major depressi... | BeFree | 19309019 | Detail |
0.001 | Autism Spectrum Disorders | Catechol-O-methyltransferase Val158Met polymorphism and risk of autism spectrum ... | BeFree | 23613504 | Detail |
0.236 | Pain | The Val158Met polymorphism of the COMT gene is associated with increased pain se... | BeFree | 23210659 | Detail |
0.345 | schizophrenia | The COMT Val158Met polymorphism did not appear to significantly affect susceptib... | BeFree | 15118357 | Detail |
<0.001 | desquamative interstitial pneumonia | However, neither allele frequencies of COMT Val158Met nor allele frequencies of ... | BeFree | 24708432 | Detail |
0.345 | schizophrenia | These preliminary results imply that PPI is influenced by COMT Val(158)Met genot... | BeFree | 18635674 | Detail |
<0.001 | Psychoses, Drug | To investigate the involvement of COMT Val158Met and DAT1 3'-UTR VNTR genotypes ... | BeFree | 24708432 | Detail |
<0.001 | depressive disorder | Changes in severity of depression were assessed with weekly Hamilton Depression ... | BeFree | 20619611 | Detail |
0.014 | Marijuana Abuse | The relationship between catechol-O-methyltransferase gene Val158Met (COMT) poly... | BeFree | 25600541 | Detail |
0.001 | Autism Spectrum Disorders | Catechol-O-methyltransferase Val158Met polymorphism and hyperactivity symptoms i... | BeFree | 23643763 | Detail |
0.162 | panic disorder | The effects of the catechol-O-methyltransferase val158met polymorphism on white ... | BeFree | 23141115 | Detail |
0.004 | Antisocial behavior | In this paper, we review the findings regarding four polymorphisms-MAOA (Monoami... | BeFree | 24764243 | Detail |
0.032 | Psychotic Disorders | Stress reactivity associated with COMT Val158Met in patients with psychosis may ... | BeFree | 22128864 | Detail |
0.002 | Violence | Catechol-O-methyltransferase (COMT) val158met polymorphism as a risk factor for ... | BeFree | 21080103 | Detail |
0.038 | Mental Depression | In the present study, 256 patients with major depression (DSM-IV) of Caucasian d... | BeFree | 17522626 | Detail |
0.001 | Chronic schizophrenia | Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizo... | BeFree | 12372660 | Detail |
0.178 | attention deficit hyperactivity disorder | Structural correlates of COMT Val158Met polymorphism in childhood ADHD: a voxel-... | BeFree | 25495556 | Detail |
<0.001 | Impulsive aggression | The catechol o-methyltransferase (COMT) val(158)met polymorphism modulates the a... | BeFree | 19906087 | Detail |
0.329 | attention deficit hyperactivity disorder | Catechol-O-methyltransferase (COMT; Val158Met) and DA D4-receptor (DRD4; 48 bp V... | BeFree | 22617852 | Detail |
<0.001 | Abnormal involuntary movement | We examined 209 Korean schizophrenic patients using the Abnormal Involuntary Mov... | BeFree | 18424907 | Detail |
0.023 | fibromyalgia | Has catechol-O-methyltransferase genotype (Val158Met) an influence on endocrine,... | BeFree | 24503977 | Detail |
0.014 | Marijuana Abuse | We also examined a putative interaction between cannabis and Val(158)Met within ... | BeFree | 17978319 | Detail |
0.005 | Low Back Pain | The COMT rs4680 Met allele contributes to long-lasting low back pain, sciatica a... | BeFree | 22337560 | Detail |
0.032 | Psychotic Disorders | COMT Val158Met-stress interaction in psychosis: role of background psychosis ris... | BeFree | 21073668 | Detail |
0.181 | bipolar disorder | Differential association of the COMT Val158Met polymorphism with clinical phenot... | BeFree | 18571901 | Detail |
0.004 | MAJOR AFFECTIVE DISORDER 1 | Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han C... | BeFree | 9352569 | Detail |
0.226 | bipolar disorder | Functional polymorphisms in the serotonin transporter (5-HTTLPR), catechol-O-met... | BeFree | 16969276 | Detail |
0.017 | Anxiety Disorders | COMT Val(158)Met and 5HTTLPR functional loci interact to predict persistence of ... | BeFree | 17504250 | Detail |
0.162 | panic disorder | Sympathetic nervous function and the effect of the catechol-O-methyltransferase ... | BeFree | 19900710 | Detail |
0.345 | schizophrenia | The role of catechol-O-methyltransferase (COMT) val158met in prefrontal cortical... | BeFree | 17516763 | Detail |
0.005 | prostate carcinoma | No association between COMT Val158Met polymorphism and prostate cancer risk: a m... | BeFree | 23116175 | Detail |
0.001 | nervous system disorder | Genotyping of rs4680 and rs4818 Catechol-O-Methyltransferase gene polymorphisms ... | BeFree | 25929431 | Detail |
0.008 | heroin dependence | The Met allele of the functional COMT Val158Met was associated with protection f... | BeFree | 25875614 | Detail |
<0.001 | Drug usage | To investigate the involvement of COMT Val158Met and DAT1 3'-UTR VNTR genotypes ... | BeFree | 24708432 | Detail |
0.345 | schizophrenia | A common Val->Met polymorphism (rs4680) in the COMT gene, associated with inc... | BeFree | 21999147 | Detail |
0.005 | osteochondritis dissecans | In subjects of Afrikaner descent, the L/L genotype of the COMT Val158Met polymor... | BeFree | 16187774 | Detail |
<0.001 | Dysphoric mood | The paper focuses on such candidate gene polymorphisms that alter alcoholism-rel... | BeFree | 17079080 | Detail |
<0.001 | Emotional disorder | There have been several reports on the association between the Val(158)Met genet... | BeFree | 23748501 | Detail |
0.080 | prostate carcinoma | The Val158Met polymorphism of the catechol-O-methyltransferase gene is associate... | BeFree | 16126332 | Detail |
0.012 | Nonorganic psychosis | The Val158Met polymorphism of the COMT (Catechol-O-Methyltransferase) gene, invo... | BeFree | 20493536 | Detail |
0.021 | Malignant neoplasm of prostate | Lack of association between COMT Val158Met polymorphism and prostate cancer susc... | BeFree | 23257985 | Detail |
0.101 | Malignant neoplasm of breast | Val158Met Polymorphism in catechol-O-methyltransferase gene associated with risk... | BeFree | 14504192 | Detail |
<0.001 | Non-small cell lung carcinoma | In this study, we found that the COMT rs4680 SNP was significantly associated wi... | BeFree | 22658813 | Detail |
<0.001 | Chronic Cancer Pain | Previous studies have associated the catechol-O-methyltransferase (COMT) enzyme ... | BeFree | 25185591 | Detail |
0.016 | Antisocial behavior | In this paper, we review the findings regarding four polymorphisms-MAOA (Monoami... | BeFree | 24764243 | Detail |
0.291 | schizophrenia | Multifactor-dimensionality reduction analysis suggested a two locus model (rs627... | BeFree | 19207030 | Detail |
0.004 | fibromyalgia | The objective of this study was to determine the potential effects of single nuc... | BeFree | 18196244 | Detail |
0.005 | Antisocial behavior | In this paper, we review the findings regarding four polymorphisms-MAOA (Monoami... | BeFree | 24764243 | Detail |
<0.001 | ovarian carcinoma | Lack of association between the COMT rs4680 polymorphism and ovarian cancer risk... | BeFree | 25292091 | Detail |
<0.001 | Impulsive aggression | Monoamine oxidase A gene promoter (MAOA-uVNTR) and catechol-O-methyltransferase ... | BeFree | 15457497 | Detail |
0.032 | Psychotic Disorders | The COMT gene is probably not a gene for any mental disorder, but the Val158Met ... | BeFree | 17419009 | Detail |
<0.001 | Pain | These exploratory findings suggest that DRD3 Ser9Gly and COMT Val158Met may cont... | BeFree | 25102390 | Detail |
0.132 | Mental disorders | One of its most widely studied variations comprises a common single nucleotide p... | BeFree | 22138198 | Detail |
<0.001 | Anemia, Sickle Cell | Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorp... | BeFree | 25102390 | Detail |
0.178 | attention deficit hyperactivity disorder | Since our previous association studies between attention deficit hyperactivity d... | BeFree | 19941049 | Detail |
0.162 | panic disorder | Asymmetry of prefrontal cortex activities and catechol-O-methyltransferase Val15... | BeFree | 19429001 | Detail |
0.005 | PANIC DISORDER 1 | Gender-specific association between the COMT Val158Met polymorphism and openness... | BeFree | 24852514 | Detail |
0.038 | Mental Depression | The functional Val158Met polymorphism in catechol-O-methyltransferase (COMT) is ... | BeFree | 20828831 | Detail |
0.058 | prostate carcinoma | The Val158Met polymorphism of the catechol-O-methyltransferase gene is associate... | BeFree | 16126332 | Detail |
0.006 | Hallucinations | We sought to determine whether the COMT val158met polymorphism (rs4680) is assoc... | BeFree | 23069674 | Detail |
0.013 | Malignant neoplasm of lung | The COMT rs4680 A allele was positively associated with lung cancer in never smo... | BeFree | 22331461 | Detail |
0.017 | Anxiety Disorders | The interaction of early life experiences with COMT val158met affects anxiety se... | BeFree | 24118915 | Detail |
0.004 | Migraine Disorders | Look beyond Catechol-O-Methyltransferase genotype for cathecolamines derangement... | BeFree | 25929431 | Detail |
0.345 | schizophrenia | A valine/methionine polymorphism of the catechol O-methyltransferase gene at ami... | BeFree | 16542182 | Detail |
0.012 | Nonorganic psychosis | In this study, using an epidemiologically-based sample of 130 patients experienc... | BeFree | 18407467 | Detail |
0.005 | Antisocial behavior | The Val158-allele of the catechol-O-methyltransferase (COMT) Val158Met (rs4680) ... | BeFree | 25495556 | Detail |
0.012 | Nonorganic psychosis | In addition, carriers of the COMT Val(158)Met Val allele were more susceptible t... | BeFree | 17640440 | Detail |
0.345 | schizophrenia | A functional interaction between Catechol-O-Methyltransferase (COMT) Val158Met a... | BeFree | 22128864 | Detail |
0.003 | Depressive Symptoms | Catechol-O-methyltransferase gene val158met polymorphism and depressive symptoms... | BeFree | 23475824 | Detail |
0.014 | endometrial carcinoma | Contribution of catechol-O-methyltransferase Val158Met polymorphism to endometri... | BeFree | 24390993 | Detail |
0.345 | schizophrenia | Negative association between catechol-O-methyltransferase (COMT) gene Val158Met ... | BeFree | 15583953 | Detail |
0.003 | Psychotic symptom | The COMT Val(158)Met genotype may moderate the effect of stress on psychotic sym... | BeFree | 17640440 | Detail |
0.016 | Tardive Dyskinesia | Evidence from pooled data for genetic association with tardive dyskinesia (TD) s... | BeFree | 18180754 | Detail |
0.008 | Mammographic Density | In a cross-sectional study of 396 Caucasian and African-American women, we evalu... | BeFree | 12052257 | Detail |
0.001 | Drug usage | To investigate the involvement of COMT Val158Met and DAT1 3'-UTR VNTR genotypes ... | BeFree | 24708432 | Detail |
0.021 | breast carcinoma | COMT rs4680 genotypes did not have a modifying effect on the association of gree... | BeFree | 19074205 | Detail |
0.004 | dementia | No association of COMT val158met polymorphism and psychotic symptoms in Lewy bod... | BeFree | 23069674 | Detail |
<0.001 | Nonorganic psychosis | Experimental effects of Delta-9-THC on cognition and psychosis are moderated by ... | BeFree | 16936704 | Detail |
0.009 | depressive disorder | The Met allele of the Catechol-O-Methyltransferase (COMT) gene functional polymo... | BeFree | 18828035 | Detail |
<0.001 | Malignant neoplasm of female breast | We examined 135 breast cancer patients and 107 healthy controls in North Syria t... | BeFree | 22124994 | Detail |
0.345 | schizophrenia | COMT Val 158 Met polymorphism is related with interpersonal problem solving in s... | BeFree | 20570494 | Detail |
0.003 | Psychotic symptom | COMT Val(158)Met moderates the effect of stress on psychotic symptoms. | BeFree | 25068285 | Detail |
0.016 | major depressive disorder | Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical o... | BeFree | 24555772 | Detail |
0.101 | Malignant neoplasm of breast | A valine-108-methionine polymorphism in exon 4 of the catechol-O-methyltransfera... | BeFree | 11142424 | Detail |
0.262 | Malignant neoplasm of prostate | The Val158Met polymorphism of the catechol-O-methyltransferase gene is associate... | BeFree | 16126332 | Detail |
0.005 | prostate carcinoma | A total of 11 htSNPs (including COMT Val(158)Met) were selected based on the res... | BeFree | 17018638 | Detail |
0.013 | Malignant neoplasm of ovary | Lack of association between the COMT rs4680 polymorphism and ovarian cancer risk... | BeFree | 25292091 | Detail |
0.006 | Headache | The association between headache and Val158Met polymorphism in the catechol-O-me... | BeFree | 16688411 | Detail |
0.058 | Parkinson disease | Daytime sleepiness and the COMT val158met polymorphism in patients with Parkinso... | BeFree | 16453988 | Detail |
0.001 | conduct disorder | COMT Val(158)Met polymorphism has been associated with both symptoms of attentio... | BeFree | 22270685 | Detail |
0.004 | MAJOR AFFECTIVE DISORDER 9 | Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han C... | BeFree | 9352569 | Detail |
<0.001 | desquamative interstitial pneumonia | However, neither allele frequencies of COMT Val158Met nor allele frequencies of ... | BeFree | 24708432 | Detail |
0.132 | Mental disorders | To examine, in a sample of young psychiatric patients, (n = 157, mean age 17.01 ... | BeFree | 21231925 | Detail |
0.132 | Mental disorders | The catechol O-methyltransferase Val158Met polymorphism and herpes simplex virus... | BeFree | 16542182 | Detail |
0.017 | Anxiety Disorders | The data here are consistent with previous work delineating the different sympto... | BeFree | 19398820 | Detail |
0.016 | major depressive disorder | This work first showed the association of combined Leu136Leu and Val158Met varia... | BeFree | 25766270 | Detail |
0.001 | Ichthyosis bullosa of Siemens | In a regression model, the number of methionine alleles in COMT val158met was li... | BeFree | 23110189 | Detail |
0.001 | Temporomandibular Joint Dysfunction Syndrome | Results show that the COMT rs4680 (val(158)met) polymorphism is most strongly as... | BeFree | 25218601 | Detail |
<0.001 | Acute onset pain | Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorp... | BeFree | 25102390 | Detail |
0.005 | PANIC DISORDER 1 | Asymmetry of prefrontal cortex activities and catechol-O-methyltransferase Val15... | BeFree | 19429001 | Detail |
0.236 | Pain | The val158met polymorphism of human catechol-O-methyltransferase (COMT) affects ... | BeFree | 20509977 | Detail |
0.132 | Mental disorders | A functional polymorphism COMT Val158Met has been associated with psychiatric di... | BeFree | 24389396 | Detail |
0.021 | breast carcinoma | Influence of catechol-o-methyltransferase genotype (Val158Met) on endocrine, sym... | BeFree | 21974969 | Detail |
0.016 | major depressive disorder | COMT val158met influence on electroconvulsive therapy response in major depressi... | BeFree | 19309019 | Detail |
0.345 | schizophrenia | Our findings suggest that the Val158Met polymorphism of the COMT gene might cont... | BeFree | 16330500 | Detail |
0.014 | Marijuana Abuse | The COMT Val158Met genotype seems to modulate the association between cannabis a... | BeFree | 21231925 | Detail |
0.017 | Anxiety Disorders | Association between the COMT Val158Met polymorphism and propensity to anxiety in... | BeFree | 15900225 | Detail |
0.032 | Psychotic Disorders | In this study, using an epidemiologically-based sample of 130 patients experienc... | BeFree | 18407467 | Detail |
0.001 | Antisocial behavior | In this paper, we review the findings regarding four polymorphisms-MAOA (Monoami... | BeFree | 24764243 | Detail |
0.002 | uterine corpus cancer | Contribution of catechol-O-methyltransferase Val158Met polymorphism to endometri... | BeFree | 24390993 | Detail |
0.002 | Impulsive aggression | Monoamine oxidase A gene promoter (MAOA-uVNTR) and catechol-O-methyltransferase ... | BeFree | 15457497 | Detail |
0.236 | Pain | The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain res... | BeFree | 22132136 | Detail |
0.005 | Impaired cognition | Our previous work has implicated two genetic factors in the development of cogni... | BeFree | 19812213 | Detail |
0.005 | NEUROTICISM | These data suggest that involvement of the COMT locus in susceptibility to anxie... | BeFree | 15956988 | Detail |
0.021 | Malignant neoplasm of prostate | No association between COMT Val158Met polymorphism and prostate cancer risk: a m... | BeFree | 23116175 | Detail |
0.001 | Chronic schizophrenia | We analysed the COMT Val158Met polymorphism in 50 patients with chronic schizoph... | BeFree | 17383818 | Detail |
0.017 | breast carcinoma | When MnSOD Ala was combined with either cytochrome P450 1B1 CYP1B1*1 and catecho... | BeFree | 15386537 | Detail |
0.101 | Malignant neoplasm of breast | Association of COMT Val158Met polymorphism and breast cancer risk: an updated me... | BeFree | 23039364 | Detail |
0.009 | depressive disorder | The present results provide further support for a-potentially female-specific-ro... | BeFree | 22387174 | Detail |
0.181 | bipolar disorder | Functional polymorphisms in the serotonin transporter (5-HTTLPR), catechol-O-met... | BeFree | 16969276 | Detail |
0.023 | fibromyalgia | Association between the COMT Val158Met polymorphism and fibromyalgia susceptibil... | BeFree | 24951880 | Detail |
0.345 | schizophrenia | COMT Val158Met polymorphism in schizophrenia with obsessive-compulsive disorder:... | BeFree | 16043283 | Detail |
0.093 | Hypertensive disease | [COMT genotype influences the effect of alcohol on blood pressure: results from ... | GAD | 19023276 | Detail |
<0.001 | Opiate Addiction | Catechol-O-methyltransferase (COMT) gene variants: possible association of the V... | BeFree | 18270997 | Detail |
0.004 | Migraine Disorders | The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism,... | BeFree | 16688411 | Detail |
0.014 | Marijuana Abuse | Observational studies have suggested that psychometric psychosis liability and a... | BeFree | 16936704 | Detail |
0.001 | Affective Disorders, Psychotic | Catechol-O-methyltransferase Val158Met polymorphism and clinical characteristics... | BeFree | 18092319 | Detail |
0.012 | Nonorganic psychosis | Our review examined evidence of an association between the COMT Val(158)Met poly... | BeFree | 23527885 | Detail |
0.236 | Pain | Three common haplotypes of the human COMT gene, divergent in two synonymous and ... | BeFree | 19365560 | Detail |
0.345 | schizophrenia | COMT val(158)met genotype and smooth pursuit eye movements in schizophrenia. | BeFree | 19647329 | Detail |
0.001 | Manic | 64 BD type I patients (39 in manic and 25 in depressive episodes) and 75 healthy... | BeFree | 22222175 | Detail |
0.001 | TIBIAL MUSCULAR DYSTROPHY, TARDIVE | Results show that the COMT rs4680 (val(158)met) polymorphism is most strongly as... | BeFree | 25218601 | Detail |
0.345 | schizophrenia | Increased catechol-O-methyltransferase activity associated with variation in cat... | BeFree | 15450787 | Detail |
<0.001 | eclampsia | The Val158Met polymorphism was more frequent in controls than in PE patients and... | BeFree | 22886584 | Detail |
0.215 | Alcoholic Intoxication, Chronic | The paper focuses on such candidate gene polymorphisms that alter alcoholism-rel... | BeFree | 17079080 | Detail |
0.345 | schizophrenia | The relationship between catechol-O-methyltransferase gene Val158Met (COMT) poly... | BeFree | 25600541 | Detail |
0.265 | schizophrenia | Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical fun... | BeFree | 19666577 | Detail |
0.345 | schizophrenia | Association study of COMT gene Val158Met polymorphism with auditory P300 and per... | BeFree | 17071544 | Detail |
0.008 | Unipolar Depression | Effect of the COMT val158met polymorphism on white matter connectivity in patien... | BeFree | 23618651 | Detail |
0.006 | Headache | Intriguingly, in migraine patients, the COMT rs4680 polymorphism influenced head... | BeFree | 23773341 | Detail |
0.032 | Psychotic Disorders | Because of its role in catecholamine metabolism and several lines of evidence po... | BeFree | 9352569 | Detail |
0.001 | Cancer pain | The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene... | BeFree | 15927391 | Detail |
0.005 | prostate carcinoma | Lack of association between COMT Val158Met polymorphism and prostate cancer susc... | BeFree | 23257985 | Detail |
<0.001 | Carcinoma of lung | The COMT rs4680 A allele was positively associated with lung cancer in never smo... | BeFree | 22331461 | Detail |
0.007 | major depressive disorder | Dopamine 2 receptor gene (DRD2) polymorphism C957T (rs6277) and cathechol-o-meth... | BeFree | 18929622 | Detail |
0.004 | MAJOR AFFECTIVE DISORDER 4 | Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han C... | BeFree | 9352569 | Detail |
0.008 | Unipolar Depression | This work first showed the association of combined Leu136Leu and Val158Met varia... | BeFree | 25766270 | Detail |
0.181 | bipolar disorder | Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han C... | BeFree | 9352569 | Detail |
<0.001 | Fatigue | Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatig... | BeFree | 21898113 | Detail |
<0.001 | Catch - Finding of sensory dimension of pain | N = 83 female participants genotyped for COMT Val158Met received 200 mg sulpirid... | BeFree | 24773408 | Detail |
0.003 | Kidney Failure, Acute | COMT-Val158Met-polymorphism is not a risk factor for acute kidney injury after c... | BeFree | 24167357 | Detail |
<0.001 | Dysphoric mood | The paper focuses on such candidate gene polymorphisms that alter alcoholism-rel... | BeFree | 17079080 | Detail |
0.178 | attention deficit hyperactivity disorder | The functional Val158Met COMT polymorphism appears to affect a host of behaviour... | BeFree | 19946720 | Detail |
0.004 | Mental disorders | Polymorphisms of COMT Val158Met and DAT1 3'-UTR VNTR in illicit drug use and dru... | BeFree | 24708432 | Detail |
0.001 | Ichthyosis bullosa of Siemens | In this study we found an association between the val/val genotype of the val158... | BeFree | 21437260 | Detail |
<0.001 | Prolapsed lumbar disc | The COMT rs4680 Met allele contributes to long-lasting low back pain, sciatica a... | BeFree | 22337560 | Detail |
0.101 | Malignant neoplasm of breast | Association between the COMT Val158Met polymorphism and breast cancer risk: a me... | BeFree | 22297695 | Detail |
0.345 | schizophrenia | Catechol O-methyltransferase Val158Met polymorphism in schizophrenia: differenti... | BeFree | 14754787 | Detail |
0.003 | Psychotic symptom | No association of COMT val158met polymorphism and psychotic symptoms in Lewy bod... | BeFree | 23069674 | Detail |
0.012 | Nonorganic psychosis | Because of its role in catecholamine metabolism and several lines of evidence po... | BeFree | 9352569 | Detail |
0.003 | Atrial Septal Defects | We studied the association of the catechol O-methyltransferase (COMT) Val158Met ... | BeFree | 20868372 | Detail |
0.014 | Marijuana Abuse | Modulation of brain structure by catechol-O-methyltransferase Val(158) Met polym... | BeFree | 23311613 | Detail |
0.021 | Malignant neoplasm of prostate | The Val158Met polymorphism of the catechol-O-methyltransferase gene is associate... | BeFree | 16126332 | Detail |
0.345 | schizophrenia | Influence of catechol-O-methyltransferase Val158Met polymorphism on neuropsychol... | BeFree | 17383818 | Detail |
0.001 | Drug usage | The Met allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism... | BeFree | 23807274 | Detail |
0.101 | Malignant neoplasm of breast | Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatig... | BeFree | 21898113 | Detail |
0.012 | Nonorganic psychosis | Evidence that the COMT(Val158Met) polymorphism moderates sensitivity to stress i... | BeFree | 17525974 | Detail |
0.032 | Psychotic Disorders | Carriers of the COMT Val(158)Met Val allele, but not subjects with the Met/Met g... | BeFree | 18808401 | Detail |
0.101 | Malignant neoplasm of breast | COMT Val158Met polymorphism and breast cancer risk: evidence from 26 case-contro... | BeFree | 20130981 | Detail |
0.004 | MAJOR AFFECTIVE DISORDER 5 | Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han C... | BeFree | 9352569 | Detail |
0.001 | Affective Disorders, Psychotic | Catechol-O-Methyltransferase (COMT) Val158Met variations and cannabis use in fir... | BeFree | 20493536 | Detail |
0.012 | anorexia nervosa | Combined family trio and case-control analysis of the COMT Val158Met polymorphis... | BeFree | 14681918 | Detail |
0.001 | Atrial Septal Defects | The COMT gene Val158Met polymorphism may be a biomarker for phenotypic variation... | BeFree | 23613504 | Detail |
0.001 | Manic | Catechol-O-methyltransferase Val158Met polymorphism affects therapeutic response... | BeFree | 20004480 | Detail |
0.178 | attention deficit hyperactivity disorder | Variation in the catechol-O-methyltransferase Val 158 Met polymorphism associate... | BeFree | 19997043 | Detail |
0.032 | Psychotic Disorders | Evidence that the COMT(Val158Met) polymorphism moderates sensitivity to stress i... | BeFree | 17525974 | Detail |
0.162 | panic disorder | Association between the catechol-O-methyltransferase Val158Met polymorphism and ... | BeFree | 20457471 | Detail |
0.038 | Mental Depression | Our objectives were (1) to examine how baseline stress and change in stress is a... | BeFree | 22044241 | Detail |
<0.001 | Cognitive changes | In the present study, we analyzed the interaction between pharmacological treatm... | BeFree | 24656901 | Detail |
0.132 | Mental disorders | Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior i... | BeFree | 23799032 | Detail |
0.236 | Pain | These exploratory findings suggest that DRD3 Ser9Gly and COMT Val158Met may cont... | BeFree | 25102390 | Detail |
0.005 | NEUROTICISM | COMT Val158Met had an effect on Neuroticism in females by age 25 (p=0.001, Bonfe... | BeFree | 23928267 | Detail |
0.345 | schizophrenia | While it cannot be determined whether TBI influenced the association of COMT Val... | BeFree | 16387984 | Detail |
0.008 | Unipolar Depression | COMT Val158met polymorphism was genotyped in 334 Chinese major depressive disord... | BeFree | 18533273 | Detail |
<0.001 | Attention deficit-hyperactivity | COMT Val158Met polymorphism and socioeconomic status interact to predict attenti... | BeFree | 19946720 | Detail |
0.014 | Marijuana Abuse | A putative interaction between cannabis and variation at rs4680 within the catec... | BeFree | 21947654 | Detail |
0.001 | Affective Disorders, Psychotic | Lack of influence of COMT Val158Met genotype on cognition in first-episode non-a... | BeFree | 18407467 | Detail |
0.017 | Anxiety Disorders | Catechol O-methyltransferase (COMT), the major enzyme determining cortical dopam... | BeFree | 17146014 | Detail |
0.127 | Substance Withdrawal Syndrome | Our results indicate that genotyping for COMT rs4680 and SLC6A4 STin2 VNTR could... | BeFree | 24684248 | Detail |
0.002 | Chronic pain | The meta-analyses showed that fibromyalgia or chronic widespread pain is the onl... | BeFree | 22722321 | Detail |
0.016 | major depressive disorder | COMT Val158met polymorphism was genotyped in 334 Chinese major depressive disord... | BeFree | 18533273 | Detail |
0.001 | Affective Disorders, Psychotic | Catechol-O-methyltransferase Val158Met polymorphism and negative symptoms after ... | BeFree | 20591499 | Detail |
0.345 | schizophrenia | Effects of the val(158)met catechol-O-methyltransferase gene polymorphism on olf... | BeFree | 22148860 | Detail |
<0.001 | female breast carcinoma | We examined 135 breast cancer patients and 107 healthy controls in North Syria t... | BeFree | 22124994 | Detail |
0.157 | Alcoholic Intoxication, Chronic | Sex differences in the influence of COMT Val158Met on alcoholism and smoking in ... | BeFree | 16499480 | Detail |
0.345 | schizophrenia | Differential association of the COMT Val158Met polymorphism with clinical phenot... | BeFree | 18571901 | Detail |
0.001 | irritable bowel syndrome | The relationship between the val158met catechol-O-methyltransferase (COMT) polym... | BeFree | 21437260 | Detail |
0.017 | Anxiety Disorders | Results indicate a main as well as a GxE effect of the COMT Val158Met variant an... | BeFree | 22745815 | Detail |
0.003 | Substance Withdrawal Syndrome | Our results indicate that genotyping for COMT rs4680 and SLC6A4 STin2 VNTR could... | BeFree | 24684248 | Detail |
0.132 | Mental disorders | Polymorphisms of COMT Val158Met and DAT1 3'-UTR VNTR in illicit drug use and dru... | BeFree | 24708432 | Detail |
0.017 | Anxiety Disorders | Functional polymorphisms in the MAO-A uVNTR promoter gene, the COMT gene (Val158... | BeFree | 15450911 | Detail |
0.059 | Malignant neoplasm of prostate | The Val158Met polymorphism of the catechol-O-methyltransferase gene is associate... | BeFree | 16126332 | Detail |
0.059 | prostate carcinoma | The Val158Met polymorphism of the catechol-O-methyltransferase gene is associate... | BeFree | 16126332 | Detail |
<0.001 | Emotional disorder | There have been several reports on the association between the Val(158)Met genet... | BeFree | 23748501 | Detail |
<0.001 | female breast carcinoma | We examined 87 cases and 341 population controls in Taiwan to determine the asso... | BeFree | 16191465 | Detail |
0.003 | Impaired cognition | Their presence may be correlated with cognitive impairment; however, the relatio... | BeFree | 24551149 | Detail |
0.009 | depressive disorder | Our objectives were (1) to examine how baseline stress and change in stress is a... | BeFree | 22044241 | Detail |
0.345 | schizophrenia | Catechol-O-methyltransferase (COMT) val(108/158)met (rs4680) is thought to affec... | BeFree | 17707347 | Detail |
0.162 | panic disorder | Meta-analysis of COMT val158met in panic disorder: ethnic heterogeneity and gend... | BeFree | 17357147 | Detail |
0.003 | Impaired cognition | Our previous work has implicated two genetic factors in the development of cogni... | BeFree | 19812213 | Detail |
0.132 | Mental disorders | Role of the COMT gene Val158Met polymorphism in mental disorders: a review. | BeFree | 17419009 | Detail |
0.017 | Anxiety Disorders | Many of these differences are unconfirmed or minor, but some appear to be of rea... | BeFree | 17805313 | Detail |
0.003 | multiple sclerosis | Catechol-O-methyltransferase Val158Met polymorphism (rs4680) is associated with ... | BeFree | 24290452 | Detail |
0.162 | panic disorder | Influence of the catechol-O-methyltransferase val158met genotype on amygdala and... | BeFree | 18440204 | Detail |
0.345 | schizophrenia | Catechol-o-methyltransferase valine(158)methionine genotype and resting regional... | BeFree | 19892319 | Detail |
0.001 | Cancer pain | It is shown that a polymorphism in the COMT gene, Rs4680 (Val158Met), influence ... | BeFree | 19094200 | Detail |
0.097 | Malignant neoplasm of breast | When MnSOD Ala was combined with either cytochrome P450 1B1 CYP1B1*1 and catecho... | BeFree | 15386537 | Detail |
0.003 | Impaired cognition | The catechol O-methyltransferase Val158Met polymorphism and herpes simplex virus... | BeFree | 16542182 | Detail |
0.021 | breast carcinoma | A valine-108-methionine polymorphism in exon 4 of the catechol-O-methyltransfera... | BeFree | 11142424 | Detail |
0.002 | Chronic pain | This study highlights the importance of COMT rs4680 in influencing the clinical ... | BeFree | 23773341 | Detail |
0.038 | Mental Depression | The present results provide further support for a-potentially female-specific-ro... | BeFree | 22387174 | Detail |
<0.001 | Sexual abuse | The functional polymorphism of the catecholamine-O-methyl-transferase (COMT) gen... | BeFree | 20002200 | Detail |
<0.001 | Non-small cell lung carcinoma | When we corrected for multiple testing using these statistical tools, three nove... | BeFree | 18258609 | Detail |
<0.001 | Non-small cell lung carcinoma | When we corrected for multiple testing using these statistical tools, three nove... | BeFree | 18258609 | Detail |
<0.001 | Premenopausal breast cancer | Although CYP1B1 and COMT genotypes did not exhibit statistically significant ass... | BeFree | 20037207 | Detail |
<0.001 | Premenopausal breast cancer | Although CYP1B1 and COMT genotypes did not exhibit statistically significant ass... | BeFree | 20037207 | Detail |
0.329 | attention deficit hyperactivity disorder | Gene-gene interaction analysis revealed significant additive effect of DBH rs110... | BeFree | 21216270 | Detail |
0.178 | attention deficit hyperactivity disorder | Gene-gene interaction analysis revealed significant additive effect of DBH rs110... | BeFree | 21216270 | Detail |
0.114 | Malignant neoplasm of breast | Pairwise analysis showed that combinations of the ERalpha G allele with the homo... | BeFree | 18820009 | Detail |
Annotation
Annotations
Descrption | Source | Links |
---|---|---|
NM_000754.4(COMT):c.472G>A (p.Val158Met) AND CATECHOL-O-METHYLTRANSFERASE POLYMORPHISM | ClinVar | Detail |
NM_000754.4(COMT):c.472G>A (p.Val158Met) AND not specified | ClinVar | Detail |
NM_000754.4(COMT):c.472G>A (p.Val158Met) AND Tramadol response | ClinVar | Detail |
NM_000754.4(COMT):c.472G>A (p.Val158Met) AND Schizophrenia | ClinVar | Detail |
Pairwise analysis showed that combinations of the ERalpha G allele with the homozygous Trp genotype ... | DisGeNET | Detail |
Our results demonstrated initial significant associations of two SNPs for DRD2 (rs11608185, genotype... | DisGeNET | Detail |
Pairwise analysis showed that combinations of the ERalpha G allele with the homozygous Trp genotype ... | DisGeNET | Detail |
Pairwise analysis showed that combinations of the ERalpha G allele with the homozygous Trp genotype ... | DisGeNET | Detail |
The Chi-square test, multivariable logistic regression analysis with adjustment for covariates, and ... | DisGeNET | Detail |
The Chi-square test, multivariable logistic regression analysis with adjustment for covariates, and ... | DisGeNET | Detail |
The Chi-square test, multivariable logistic regression analysis with adjustment for covariates, and ... | DisGeNET | Detail |
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... | DisGeNET | Detail |
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... | DisGeNET | Detail |
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... | DisGeNET | Detail |
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... | DisGeNET | Detail |
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... | DisGeNET | Detail |
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... | DisGeNET | Detail |
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... | DisGeNET | Detail |
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... | DisGeNET | Detail |
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... | DisGeNET | Detail |
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... | DisGeNET | Detail |
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... | DisGeNET | Detail |
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... | DisGeNET | Detail |
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... | DisGeNET | Detail |
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... | DisGeNET | Detail |
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... | DisGeNET | Detail |
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... | DisGeNET | Detail |
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... | DisGeNET | Detail |
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... | DisGeNET | Detail |
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... | DisGeNET | Detail |
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... | DisGeNET | Detail |
Nine gene-candidates, including 5-HTTLPR, MAO-A VNTR, TPH2 rs1386494, 5-HTR1A -1019C-G, 5-HTR2A 102T... | DisGeNET | Detail |
Nine gene-candidates, including 5-HTTLPR, MAO-A VNTR, TPH2 rs1386494, 5-HTR1A -1019C-G, 5-HTR2A 102T... | DisGeNET | Detail |
Nine gene-candidates, including 5-HTTLPR, MAO-A VNTR, TPH2 rs1386494, 5-HTR1A -1019C-G, 5-HTR2A 102T... | DisGeNET | Detail |
Nine gene-candidates, including 5-HTTLPR, MAO-A VNTR, TPH2 rs1386494, 5-HTR1A -1019C-G, 5-HTR2A 102T... | DisGeNET | Detail |
We genotyped a sample of 45 adults with ADHD at four candidate polymorphisms for the disorder (DRD4 ... | DisGeNET | Detail |
We genotyped a sample of 45 adults with ADHD at four candidate polymorphisms for the disorder (DRD4 ... | DisGeNET | Detail |
We genotyped a sample of 45 adults with ADHD at four candidate polymorphisms for the disorder (DRD4 ... | DisGeNET | Detail |
We genotyped a sample of 45 adults with ADHD at four candidate polymorphisms for the disorder (DRD4 ... | DisGeNET | Detail |
Stage 1 analysis included 290 patients with epilepsy and revealed a higher load of adverse psychotro... | DisGeNET | Detail |
Stage 1 analysis included 290 patients with epilepsy and revealed a higher load of adverse psychotro... | DisGeNET | Detail |
We find that P50 and PPI may be influenced by COMT rs4680 polymorphisms in schizophrenia; more excit... | DisGeNET | Detail |
A common functional polymorphism, Val108/158Met (rs4680), and haplotypes rs737865-rs4680-rs165599 in... | DisGeNET | Detail |
We find that P50 and PPI may be influenced by COMT rs4680 polymorphisms in schizophrenia; more excit... | DisGeNET | Detail |
To determine whether COMT is important in substance dependence, rs165774 and rs4680 were genotyped a... | DisGeNET | Detail |
It is possible that the rs165774 SNP, in combination with rs4680, results in a common molecular vari... | DisGeNET | Detail |
The increased volumes in the genu, splenium and total CC in the 22q11DS group were associated with p... | DisGeNET | Detail |
The increased volumes in the genu, splenium and total CC in the 22q11DS group were associated with p... | DisGeNET | Detail |
The increased volumes in the genu, splenium and total CC in the 22q11DS group were associated with p... | DisGeNET | Detail |
The increased volumes in the genu, splenium and total CC in the 22q11DS group were associated with p... | DisGeNET | Detail |
The increased volumes in the genu, splenium and total CC in the 22q11DS group were associated with p... | DisGeNET | Detail |
The increased volumes in the genu, splenium and total CC in the 22q11DS group were associated with p... | DisGeNET | Detail |
Patients with EH (n = 89), EH concurrent with ECa (n = 76), ECa (n = 186), and healthy controls (n =... | DisGeNET | Detail |
Patients with EH (n = 89), EH concurrent with ECa (n = 76), ECa (n = 186), and healthy controls (n =... | DisGeNET | Detail |
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... | DisGeNET | Detail |
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... | DisGeNET | Detail |
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... | DisGeNET | Detail |
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... | DisGeNET | Detail |
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... | DisGeNET | Detail |
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... | DisGeNET | Detail |
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... | DisGeNET | Detail |
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... | DisGeNET | Detail |
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... | DisGeNET | Detail |
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... | DisGeNET | Detail |
Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) polymorphisms were ana... | DisGeNET | Detail |
We explored the influence of interactions between polymorphisms acting upon postsynaptic receptors (... | DisGeNET | Detail |
Age, gender, Fagerström Test for Nicotine Dependence, dopamine pathway genotypes (rs1800497 [ANKK1 E... | DisGeNET | Detail |
We explored the influence of interactions between polymorphisms acting upon postsynaptic receptors (... | DisGeNET | Detail |
We explored the influence of interactions between polymorphisms acting upon postsynaptic receptors (... | DisGeNET | Detail |
We explored the influence of interactions between polymorphisms acting upon postsynaptic receptors (... | DisGeNET | Detail |
Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) polymorphisms were ana... | DisGeNET | Detail |
We explored the influence of interactions between polymorphisms acting upon postsynaptic receptors (... | DisGeNET | Detail |
Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) polymorphisms were ana... | DisGeNET | Detail |
We explored the influence of interactions between polymorphisms acting upon postsynaptic receptors (... | DisGeNET | Detail |
Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) polymorphisms were ana... | DisGeNET | Detail |
We explored the influence of interactions between polymorphisms acting upon postsynaptic receptors (... | DisGeNET | Detail |
We explored the influence of interactions between polymorphisms acting upon postsynaptic receptors (... | DisGeNET | Detail |
Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) polymorphisms were ana... | DisGeNET | Detail |
Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) polymorphisms were ana... | DisGeNET | Detail |
The investigation of the catechol-O-methyltransferase (COMT-[rs4680]) and methylenetetrahydrofolate ... | DisGeNET | Detail |
The investigation of the catechol-O-methyltransferase (COMT-[rs4680]) and methylenetetrahydrofolate ... | DisGeNET | Detail |
The G/G homozygous genotype in COMT rs4680 and A/A homozygous genotype in PLCH1 rs181696 were associ... | DisGeNET | Detail |
The G/G homozygous genotype in COMT rs4680 and A/A homozygous genotype in PLCH1 rs181696 were associ... | DisGeNET | Detail |
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... | DisGeNET | Detail |
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... | DisGeNET | Detail |
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... | DisGeNET | Detail |
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... | DisGeNET | Detail |
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... | DisGeNET | Detail |
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... | DisGeNET | Detail |
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... | DisGeNET | Detail |
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... | DisGeNET | Detail |
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... | DisGeNET | Detail |
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... | DisGeNET | Detail |
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... | DisGeNET | Detail |
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... | DisGeNET | Detail |
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... | DisGeNET | Detail |
The genetic polymorphism of rs3087869 (IVS1+2329C>T) (OR 3.200, 95% CI 1.614-6.345) and rs4680 (V... | DisGeNET | Detail |
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... | DisGeNET | Detail |
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... | DisGeNET | Detail |
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... | DisGeNET | Detail |
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... | DisGeNET | Detail |
The genetic polymorphism of rs3087869 (IVS1+2329C>T) (OR 3.200, 95% CI 1.614-6.345) and rs4680 (V... | DisGeNET | Detail |
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... | DisGeNET | Detail |
The genetic polymorphisms of IVS1+2329C>T and Val158Met loci in COMT, Ile462Val and Gly45Asp loci... | DisGeNET | Detail |
The genetic polymorphisms of IVS1+2329C>T and Val158Met loci in COMT, Ile462Val and Gly45Asp loci... | DisGeNET | Detail |
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... | DisGeNET | Detail |
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... | DisGeNET | Detail |
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... | DisGeNET | Detail |
The genetic polymorphism of rs3087869 (IVS1+2329C>T) (OR 3.200, 95% CI 1.614-6.345) and rs4680 (V... | DisGeNET | Detail |
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... | DisGeNET | Detail |
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... | DisGeNET | Detail |
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... | DisGeNET | Detail |
The genetic polymorphisms of IVS1+2329C>T and Val158Met loci in COMT, Ile462Val and Gly45Asp loci... | DisGeNET | Detail |
We assessed catechol-O-methyltransferase (COMT) Val108/158Met (rs4680) and dopamine D2 receptor (DRD... | DisGeNET | Detail |
We assessed catechol-O-methyltransferase (COMT) Val108/158Met (rs4680) and dopamine D2 receptor (DRD... | DisGeNET | Detail |
Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms (SNP) of the CNR1 (r... | DisGeNET | Detail |
Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms (SNP) of the CNR1 (r... | DisGeNET | Detail |
Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms (SNP) of the CNR1 (r... | DisGeNET | Detail |
Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms (SNP) of the CNR1 (r... | DisGeNET | Detail |
Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms (SNP) of the CNR1 (r... | DisGeNET | Detail |
Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms (SNP) of the CNR1 (r... | DisGeNET | Detail |
Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-deriv... | DisGeNET | Detail |
However, genetic effects (COMT Val(158)Met and BDNF Val(66)Met) on experimental pain were moderated ... | DisGeNET | Detail |
Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-deriv... | DisGeNET | Detail |
Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics i... | DisGeNET | Detail |
Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-deriv... | DisGeNET | Detail |
Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics i... | DisGeNET | Detail |
Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-deriv... | DisGeNET | Detail |
Patients were also genotyped for three polymorphisms associated with cognitive change in Parkinson's... | DisGeNET | Detail |
Patients were also genotyped for three polymorphisms associated with cognitive change in Parkinson's... | DisGeNET | Detail |
Patients were also genotyped for three polymorphisms associated with cognitive change in Parkinson's... | DisGeNET | Detail |
Results from this study suggest that rs4680 in the COMT gene and rs4646903 in the CYP1A1 gene may be... | DisGeNET | Detail |
Results from this study suggest that rs4680 in the COMT gene and rs4646903 in the CYP1A1 gene may be... | DisGeNET | Detail |
Results from this study suggest that rs4680 in the COMT gene and rs4646903 in the CYP1A1 gene may be... | DisGeNET | Detail |
Results from this study suggest that rs4680 in the COMT gene and rs4646903 in the CYP1A1 gene may be... | DisGeNET | Detail |
Functional polymorphisms in the MAO-A uVNTR promoter gene, the COMT gene (Val158Met) exon 4, and the... | DisGeNET | Detail |
Catechol-O-methyltransferase Val158Met polymorphism influences anxiety, depression, and disability, ... | DisGeNET | Detail |
COMT Val(158) met genotype and striatal D(2/3) receptor binding in adults with 22q11 deletion syndro... | DisGeNET | Detail |
Catechol-O-methyltransferase Val158Met polymorphism moderates anterior cingulate volume in posttraum... | DisGeNET | Detail |
Many of these differences are unconfirmed or minor, but some appear to be of reasonable robustness a... | DisGeNET | Detail |
Only Val158Met polymorphism of the catechol-O-methyltransferase gene has been implicated in suscepti... | DisGeNET | Detail |
The paper focuses on such candidate gene polymorphisms that alter alcoholism-related intermediate ph... | DisGeNET | Detail |
We investigated the associations between COMT Val(158)Met and depression in a Swedish population-bas... | DisGeNET | Detail |
In addition, carriers of the COMT Val(158)Met Val allele were more susceptible to the effect of stre... | DisGeNET | Detail |
Sympathetic nervous function and the effect of the catechol-O-methyltransferase Val(158)Met polymorp... | DisGeNET | Detail |
The associations between the Val158Met in the catechol-O-methyltransferase (COMT) gene and the risk ... | DisGeNET | Detail |
We examined 87 cases and 341 population controls in Taiwan to determine the association between the ... | DisGeNET | Detail |
The functional Val158Met polymorphism in catechol-O-methyltransferase (COMT) is associated with depr... | DisGeNET | Detail |
Reduced dopamine receptor sensitivity as an intermediate phenotype in alcohol dependence and the rol... | DisGeNET | Detail |
We studied the association of the catechol O-methyltransferase (COMT) Val158Met polymorphism and the... | DisGeNET | Detail |
Our review examined evidence of an association between the COMT Val(158)Met polymorphism and both ne... | DisGeNET | Detail |
No association found between 158 Val/Met polymorphism of the COMT gene and schizophrenia with minor ... | DisGeNET | Detail |
Cannabis use profiles and COMT Val158Met genotypes were obtained from 80 inpatients with schizophren... | DisGeNET | Detail |
[The effects of gender and catechol O-methyltransferase (COMT) Val108/158Met polymorphism on emotion... | DisGeNET | Detail |
Our results indicate that genotyping for COMT rs4680 and SLC6A4 STin2 VNTR could be useful for the i... | DisGeNET | Detail |
Evidence from pooled data for genetic association with tardive dyskinesia (TD) showed (1) in COMT(va... | DisGeNET | Detail |
Association of the catechol-O-methyltransferase val158met polymorphism and anxiety-related traits: a... | DisGeNET | Detail |
This work first showed the association of combined Leu136Leu and Val158Met variants of COMT gene wit... | DisGeNET | Detail |
The catechol-O-methyltransferase (COMT) Val158Met polymorphism may be a risk factor for nicotine add... | DisGeNET | Detail |
Clinical symptoms in fibromyalgia are associated to catechol-O-methyltransferase (COMT) gene Val158M... | DisGeNET | Detail |
Catechol-O-methyltransferase Val158Met polymorphism in relation to aggressive schizophrenia in a Kor... | DisGeNET | Detail |
Our results indicate that genotyping for COMT rs4680 and SLC6A4 STin2 VNTR could be useful for the i... | DisGeNET | Detail |
The common methionine (met) for valine (val) at codon 158 (val(158)met) polymorphism in the catechol... | DisGeNET | Detail |
No association between the Catechol-O-Methyltransferase (COMT) val158met polymorphism and cognitive ... | DisGeNET | Detail |
Interaction between catechol-O-methyltransferase (COMT) Val158Met genotype and genetic vulnerability... | DisGeNET | Detail |
In subjects of Afrikaner descent, the L/L genotype of the COMT Val158Met polymorphism was significan... | DisGeNET | Detail |
Both the COMT Val158Met polymorphism and serological evidence of HSV-1 infection affect cognitive fu... | DisGeNET | Detail |
Here, we report the investigation of the differential activity of membrane-bound catechol-O-methyltr... | DisGeNET | Detail |
Dopamine 2 receptor gene (DRD2) polymorphism C957T (rs6277) and cathechol-o-methyltransferase (COMT)... | DisGeNET | Detail |
Carriers of the COMT Val(158)Met Val allele, but not subjects with the Met/Met genotype, showed an i... | DisGeNET | Detail |
Polymorphisms of COMT Val158Met and DAT1 3'-UTR VNTR in illicit drug use and drug-related psychiatri... | DisGeNET | Detail |
Association of COMT Val158Met polymorphism and breast cancer risk: an updated meta-analysis. | DisGeNET | Detail |
Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical function in healthy sub... | DisGeNET | Detail |
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progr... | DisGeNET | Detail |
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progr... | DisGeNET | Detail |
Cannabis use and age at onset of psychosis: further evidence of interaction with COMT Val158Met poly... | DisGeNET | Detail |
The present results provide further support for a-potentially female-specific-role of the COMT val15... | DisGeNET | Detail |
The risk of posttraumatic stress disorder after trauma depends on traumatic load and the catechol-o-... | DisGeNET | Detail |
The aim of the study was to evaluate the influence of COMT Val158Met polymorphism genotype in the ph... | DisGeNET | Detail |
These results do not support the hypothesis that the COMT Val158Met gene polymorphism is associated ... | DisGeNET | Detail |
Gender-specific association between the COMT Val158Met polymorphism and openness to experience in pa... | DisGeNET | Detail |
The catechol o-methyltransferase (COMT) val(158)met polymorphism modulates the association of seriou... | DisGeNET | Detail |
Genetic contribution of catechol-O-methyltransferase polymorphism (Val158Met) in children with chron... | DisGeNET | Detail |
A coding variant in one such gene, encoding the dopamine catabolic enzyme catechol-O-methyltransfera... | DisGeNET | Detail |
[We evaluated the association of COMT genotype at this locus with blood pressure (BP) in 839 alcohol... | DisGeNET | Detail |
Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and ... | DisGeNET | Detail |
The paper focuses on such candidate gene polymorphisms that alter alcoholism-related intermediate ph... | DisGeNET | Detail |
Association of the COMT val158met variant with antidepressant treatment response in major depression... | DisGeNET | Detail |
The impact of the Val158Met catechol-O-methyltransferase genotype on neural correlates of sad facial... | DisGeNET | Detail |
The data here are consistent with previous work delineating the different symptom subtypes of OCD, a... | DisGeNET | Detail |
Contribution of catechol-O-methyltransferase Val158Met polymorphism to endometrial cancer risk in po... | DisGeNET | Detail |
Our study indicates an association between rs4680, an SNP in the COMT gene, and lower risk of apathy... | DisGeNET | Detail |
A putative interaction between cannabis and variation at rs4680 within the catechol-methyl-transfera... | DisGeNET | Detail |
The COMT val(158)met polymorphism was associated with abstinence-related working memory deficits in ... | DisGeNET | Detail |
Compared with nonsmokers, European-American COMT Val158Met double-variant carriers who smoked had in... | DisGeNET | Detail |
Previous studies of a functional variant of the catechol-O-methyl transferase (COMT) gene, Val158Met... | DisGeNET | Detail |
Effect of catechol O-methyltransferase val(158)met polymorphism on the p50 gating endophenotype in s... | DisGeNET | Detail |
Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in irritable bowel syndr... | DisGeNET | Detail |
Association of the COMT val158met variant with antidepressant treatment response in major depression... | DisGeNET | Detail |
Catechol-O-Methyltransferase (COMT) Val158Met variations and cannabis use in first-episode non-affec... | DisGeNET | Detail |
COMT Val158Met modulates the effect of childhood adverse experiences on the risk of alcohol dependen... | DisGeNET | Detail |
This study aimed to derive a comprehensive, whole-brain characterization of large-scale axonal conne... | DisGeNET | Detail |
COMT Val 158 Met polymorphism is associated with cognitive flexibility in a signal discrimination ta... | DisGeNET | Detail |
To better evaluate the role of COMT Val158Met in endometrial carcinogenesis, we performed this meta-... | DisGeNET | Detail |
Moreover, variations in the COMT Val158Met functional polymorphism have been associated with prefron... | DisGeNET | Detail |
Association of the COMT synonymous polymorphism Leu136Leu and missense variant Val158Met with mood d... | DisGeNET | Detail |
Catechol O-methyltransferase val158-met polymorphism is associated with abdominal obesity and blood ... | DisGeNET | Detail |
We sought to determine whether the COMT val158met polymorphism (rs4680) is associated with delusions... | DisGeNET | Detail |
Functional polymorphisms in the MAO-A uVNTR promoter gene, the COMT gene (Val158Met) exon 4, and the... | DisGeNET | Detail |
This study tested the hypothesis that genetic variation in COMT Val158Met and DRD2/ANKK1 Taq1A inter... | DisGeNET | Detail |
Association study of catechol-O-methyltransferase (COMT) gene Val158Met polymorphism with auditory P... | DisGeNET | Detail |
The purpose of our study is to examine the association between Ala72Ser and Val158Met functional pol... | DisGeNET | Detail |
In the present study, 256 patients with major depression (DSM-IV) of Caucasian descent were genotype... | DisGeNET | Detail |
Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met gen... | DisGeNET | Detail |
Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorphisms and acute pain... | DisGeNET | Detail |
Catechol-O-methyltransferase Val158Met polymorphism in schizophrenia: associations with cognitive an... | DisGeNET | Detail |
Catechol-O-methyltransferase Val158Met and the risk of dyskinesias in Parkinson's disease. | DisGeNET | Detail |
Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and ... | DisGeNET | Detail |
The Val158Met polymorphism of the COMT (Catechol-O-Methyltransferase) gene, involved in dopamine reg... | DisGeNET | Detail |
A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive p... | DisGeNET | Detail |
Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond. | DisGeNET | Detail |
A total of 11 htSNPs (including COMT Val(158)Met) were selected based on the resequencing and dense ... | DisGeNET | Detail |
Association between the catechol-O-methyltransferase Val158Met polymorphism and panic disorder: a re... | DisGeNET | Detail |
Associations between COMT Val(158)Met genotype and RTV do not appear to reflect transmission of schi... | DisGeNET | Detail |
Among those with history of psychiatric problems, the COMT-Val158Met and 5HTT-LPR risk variants were... | DisGeNET | Detail |
Catechol-O-methyltransferase Val(158)Met association with parahippocampal physiology during memory e... | DisGeNET | Detail |
Influence of the catechol-O-methyltransferase val158met genotype on amygdala and prefrontal cortex e... | DisGeNET | Detail |
In this study, we found that the COMT rs4680 SNP was significantly associated with a reduced risk of... | DisGeNET | Detail |
We examined if the COMT Val158Met SNP could contribute to discogenic subacute low back pain and scia... | DisGeNET | Detail |
A functional interaction between Catechol-O-Methyltransferase (COMT) Val158Met and methylenetetrahyd... | DisGeNET | Detail |
Catechol-O-methyltransferase valine158methionine polymorphism moderates methylphenidate effects on o... | DisGeNET | Detail |
These results suggest that SNPs rs4680 and rs4818 of the COMT gene may be associated with fibromyalg... | DisGeNET | Detail |
To investigate the involvement of COMT Val158Met and DAT1 3'-UTR VNTR genotypes in the pathogenesis ... | DisGeNET | Detail |
Heterozygosity at catechol-O-methyltransferase Val158Met and schizophrenia: new data and meta-analys... | DisGeNET | Detail |
The Val158Met polymorphism of the gene encoding catechol-O-methyltransferase (COMT) is one of the mo... | DisGeNET | Detail |
To investigate the involvement of COMT Val158Met and DAT1 3'-UTR VNTR genotypes in the pathogenesis ... | DisGeNET | Detail |
The aim of this study is to examine the influence of the catechol-O-methyltranferase (COMT) gene (po... | DisGeNET | Detail |
This is the first study suggesting that COMT rs4680 modulates FER differently during BD episodes and... | DisGeNET | Detail |
COMT Val158Met-stress interaction in psychosis: role of background psychosis risk. | DisGeNET | Detail |
Catechol-O-methyltransferase Val158Met polymorphism is associated with pain and disability, but not ... | DisGeNET | Detail |
The present study investigated the effects of familial risk for depression and the 5-HTTLPR and COMT... | DisGeNET | Detail |
Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorphisms and acute pain... | DisGeNET | Detail |
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progr... | DisGeNET | Detail |
Variation in the catechol-O-methyltransferase Val 158 Met polymorphism associated with conduct disor... | DisGeNET | Detail |
Functional polymorphisms in the serotonin transporter (5-HTTLPR), catechol-O-methyltransferase (Val1... | DisGeNET | Detail |
Anhedonia as a phenotype for the Val158Met COMT polymorphism in relatives of patients with schizophr... | DisGeNET | Detail |
We show that Val/Val but neither Met/Met nor Val/Met carriers of the catechol-O-methyltransferase (C... | DisGeNET | Detail |
Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and ... | DisGeNET | Detail |
Catechol-O-methyltransferase Val158Met polymorphism and breast cancer risk in Asian population. | DisGeNET | Detail |
Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical outcomes in patients ... | DisGeNET | Detail |
Previous studies have shown that the met allele of the COMT val158met single nucleotide polymorphism... | DisGeNET | Detail |
Effect of catechol O-methyltransferase val(158)met polymorphism on the p50 gating endophenotype in s... | DisGeNET | Detail |
Functional COMT Val158Met polymorphism, risk of acute coronary events and serum homocysteine: the Ku... | DisGeNET | Detail |
Effect of the COMT val158met polymorphism on white matter connectivity in patients with major depres... | DisGeNET | Detail |
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progr... | DisGeNET | Detail |
Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical outcomes in patients ... | DisGeNET | Detail |
Stress reactivity associated with COMT Val158Met in patients with psychosis may crucially depend on ... | DisGeNET | Detail |
We examined 87 cases and 341 population controls in Taiwan to determine the association between the ... | DisGeNET | Detail |
Catechol-O-methyltransferase Val158Met polymorphism and breast cancer risk in Asian population. | DisGeNET | Detail |
Negative association between catechol-O-methyltransferase (COMT) gene Val158Met polymorphism and per... | DisGeNET | Detail |
We investigated the associations between COMT Val(158)Met and depression in a Swedish population-bas... | DisGeNET | Detail |
Changes in severity of depression were assessed with weekly Hamilton Depression ratings and analyzed... | DisGeNET | Detail |
No evidence of association between Catechol-O-Methyltransferase (COMT) Val158Met genotype and perfor... | DisGeNET | Detail |
This case control study investigated whether polymorphisms of estrogen metabolizing genes CYP1A1 Msp... | DisGeNET | Detail |
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progr... | DisGeNET | Detail |
Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress... | DisGeNET | Detail |
To investigate the involvement of COMT Val158Met and DAT1 3'-UTR VNTR genotypes in the pathogenesis ... | DisGeNET | Detail |
Catechol-O-methyltransferase Val158Met polymorphism influences anxiety, depression, and disability, ... | DisGeNET | Detail |
COMT Val158Met polymorphism in schizophrenia with obsessive-compulsive disorder: a case-control stud... | DisGeNET | Detail |
Catechol-O-methyltransferase (COMT; Val158Met) and DA D4-receptor (DRD4; 48 bp VNTR) genotypes were ... | DisGeNET | Detail |
We investigated the associations between COMT Val(158)Met and depression in a Swedish population-bas... | DisGeNET | Detail |
Opposite effects of catechol-O-methyltransferase Val158Met on cortical function in healthy subjects ... | DisGeNET | Detail |
Based on the pivotal role ascribed to the prefrontal executive control network for absorbed attentio... | DisGeNET | Detail |
The present study investigated the effects of familial risk for depression and the 5-HTTLPR and COMT... | DisGeNET | Detail |
COMT Val158Met polymorphism in relation to activation and de-activation in the prefrontal cortex: A ... | DisGeNET | Detail |
The present study investigated the effects of familial risk for depression and the 5-HTTLPR and COMT... | DisGeNET | Detail |
Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatigue and pain sensitiv... | DisGeNET | Detail |
The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been found to affect fear extinct... | DisGeNET | Detail |
Association between the COMT Val158Met polymorphism and breast cancer risk: a meta-analysis of 30,19... | DisGeNET | Detail |
Prefrontal dysfunction in schizophrenia controlling for COMT Val158Met genotype and working memory p... | DisGeNET | Detail |
Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical outcomes in patients ... | DisGeNET | Detail |
An experimental study of catechol-o-methyltransferase Val158Met moderation of delta-9-tetrahydrocann... | DisGeNET | Detail |
COMT Val(158)Met polymorphism was studied with ARMS-PCR method in 99 outpatients with schizophrenia. | DisGeNET | Detail |
Genetic polymorphism Val158Met of catechol-O-methyltransferase (COMT) may contribute to estrogen-ind... | DisGeNET | Detail |
Catechol-O-methyltransferase Val158Met polymorphism is associated with methylphenidate response in A... | DisGeNET | Detail |
Here, we report the investigation of the differential activity of membrane-bound catechol-O-methyltr... | DisGeNET | Detail |
COMT Val158Met variant and functional haplotypes associated with childhood ADHD history in women wit... | DisGeNET | Detail |
We also found a significant interaction effect of COMT met alleles (β = -32.5 SE 14.1, P = 0.021). i... | DisGeNET | Detail |
The Met allele of the Catechol-O-Methyltransferase (COMT) gene functional polymorphism (COMT-V158M) ... | DisGeNET | Detail |
The catechol O-methyltransferase Val158Met polymorphism and herpes simplex virus type 1 infection ar... | DisGeNET | Detail |
Evidence from pooled data for genetic association with tardive dyskinesia (TD) showed (1) in COMT(va... | DisGeNET | Detail |
Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond. | DisGeNET | Detail |
The COMT rs4680 A allele was negatively related with the risk of spina bifida, with adjusted OR = 0.... | DisGeNET | Detail |
Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence. | DisGeNET | Detail |
Val158Met Polymorphism in catechol-O-methyltransferase gene associated with risk factors for breast ... | DisGeNET | Detail |
Therefore, we evaluated the following ten estrogen metabolism-associated single-nucleotide polymorph... | DisGeNET | Detail |
Influence of COMT Val158Met polymorphism on Alzheimer's disease and mild cognitive impairment in Ita... | DisGeNET | Detail |
COMT Val158Met polymorphism and breast cancer risk: evidence from 26 case-control studies. | DisGeNET | Detail |
Results indicate a main as well as a GxE effect of the COMT Val158Met variant and childhood maltreat... | DisGeNET | Detail |
Only Val158Met polymorphism of the catechol-O-methyltransferase gene has been implicated in suscepti... | DisGeNET | Detail |
Among those with history of psychiatric problems, the COMT-Val158Met and 5HTT-LPR risk variants were... | DisGeNET | Detail |
Catechol-O-methyltransferase Val 158 Met polymorphism and antisaccade eye movements in schizophrenia... | DisGeNET | Detail |
An experimental study of catechol-o-methyltransferase Val158Met moderation of delta-9-tetrahydrocann... | DisGeNET | Detail |
Influence of catechol-o-methyltransferase genotype (Val158Met) on endocrine, sympathetic nervous and... | DisGeNET | Detail |
No evidence for an effect of COMT Val158Met genotype on executive function in patients with 22q11 de... | DisGeNET | Detail |
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progr... | DisGeNET | Detail |
Functional polymorphisms in the MAO-A uVNTR promoter gene, the COMT gene (Val158Met) exon 4, and the... | DisGeNET | Detail |
Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress... | DisGeNET | Detail |
Depression and anxiety in relation to catechol-O-methyltransferase Val158Met genotype in the general... | DisGeNET | Detail |
Given that catechol-O-methyltransferase (COMT) is widely distributed in the hippocampus and its gene... | DisGeNET | Detail |
Val158Met is a common single-nucleotide polymorphism of the COMT gene (Ex4-12 G>A; rs4680) that r... | DisGeNET | Detail |
The paper focuses on such candidate gene polymorphisms that alter alcoholism-related intermediate ph... | DisGeNET | Detail |
When MnSOD Ala was combined with either cytochrome P450 1B1 CYP1B1*1 and catechol O-methyltransferas... | DisGeNET | Detail |
A functional polymorphism of the COMT gene, val158met, has been linked to internalizing symptoms (i.... | DisGeNET | Detail |
The relationship between a common catechol-O-methyltransferase (COMT) polymorphism val(158) met and ... | DisGeNET | Detail |
This study suggests that the Val158Met COMT polymorphism modulated some psychological variables but ... | DisGeNET | Detail |
COMT Val158Met and DRD2 Taq1A may confer their risk of alcohol dependence through reduced dopamine r... | DisGeNET | Detail |
We examined 87 cases and 341 population controls in Taiwan to determine the association between the ... | DisGeNET | Detail |
Cannabis use and age at onset of psychosis: further evidence of interaction with COMT Val158Met poly... | DisGeNET | Detail |
A functional Val158Met polymorphism in the COMT gene has been known as a susceptible marker for brea... | DisGeNET | Detail |
Given that catechol-O-methyltransferase (COMT) is widely distributed in the hippocampus and its gene... | DisGeNET | Detail |
Experimental effects of Delta-9-THC on cognition and psychosis are moderated by COMT Val(158)Met gen... | DisGeNET | Detail |
In a cross-sectional study of 396 Caucasian and African-American women, we evaluated whether polymor... | DisGeNET | Detail |
COMT Val(158)Met polymorphism has been associated with both symptoms of attention-deficit/hyperactiv... | DisGeNET | Detail |
However, neither allele frequencies of COMT Val158Met nor allele frequencies of DAT1 3'-UTR VNTR wer... | DisGeNET | Detail |
Association of COMT Val158Met polymorphism with wearing-off susceptibility in Parkinson's disease. | DisGeNET | Detail |
A well-characterized single nucleotide polymorphism (472G/A-Val/Met-SNP8) in the coding sequence of ... | DisGeNET | Detail |
The findings provide independent support for the hypothesis that the catechol-O-methyltransferase Va... | DisGeNET | Detail |
A functional Val158Met polymorphism in the COMT gene has been known as a susceptible marker for brea... | DisGeNET | Detail |
Meta-analysis of COMT val158met in panic disorder: ethnic heterogeneity and gender specificity. | DisGeNET | Detail |
Val158Met polymorphism of COMT gene and Parkinson's disease risk in Asians. | DisGeNET | Detail |
The val158met polymorphism of the COMT gene exemplifies the lack of consensus in the literature: alt... | DisGeNET | Detail |
A putative interaction between cannabis and variation at rs4680 within the catechol-methyl-transfera... | DisGeNET | Detail |
Evidence from pooled data for genetic association with tardive dyskinesia (TD) showed (1) in COMT(va... | DisGeNET | Detail |
Therefore, we evaluated the following ten estrogen metabolism-associated single-nucleotide polymorph... | DisGeNET | Detail |
Genetic association of catechol-O-methyltransferase val(158)met polymorphism in Saudi schizophrenia ... | DisGeNET | Detail |
Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and ... | DisGeNET | Detail |
The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met which has... | DisGeNET | Detail |
No association of COMT Val158Met polymorphism with suicidal behavior or CSF monoamine metabolites in... | DisGeNET | Detail |
The data here are consistent with previous work delineating the different symptom subtypes of OCD, a... | DisGeNET | Detail |
The findings suggest that the COMT(Val158Met) polymorphism moderates affective and psychotic respons... | DisGeNET | Detail |
The C957T polymorphism in the dopamine D2 receptor (DRD2) gene and the Val158Met polymorphism in the... | DisGeNET | Detail |
The aim of this study is to examine the influence of the catechol-O-methyltranferase (COMT) gene (po... | DisGeNET | Detail |
COMT Val158Met variant and functional haplotypes associated with childhood ADHD history in women wit... | DisGeNET | Detail |
The aim of this study is to examine the role of the COMT gene Val158Met polymorphism on the clinical... | DisGeNET | Detail |
When MnSOD Ala was combined with either cytochrome P450 1B1 CYP1B1*1 and catechol O-methyltransferas... | DisGeNET | Detail |
COMT rs4680 genotypes did not have a modifying effect on the association of green tea intake with br... | DisGeNET | Detail |
Catechol-O-methyltransferase Val158Met polymorphism: modulation of wearing-off susceptibility in a C... | DisGeNET | Detail |
A meta-analysis of the Val158Met COMT polymorphism and violent behavior in schizophrenia. | DisGeNET | Detail |
The effects of the catechol-O-methyltransferase val158met polymorphism on white matter connectivity ... | DisGeNET | Detail |
The val158met polymorphism of the COMT gene exemplifies the lack of consensus in the literature: alt... | DisGeNET | Detail |
Negative association between catechol-O-methyltransferase (COMT) gene Val158Met polymorphism and per... | DisGeNET | Detail |
COMT val158met influence on electroconvulsive therapy response in major depression. | DisGeNET | Detail |
Catechol-O-methyltransferase Val158Met polymorphism and risk of autism spectrum disorders. | DisGeNET | Detail |
The Val158Met polymorphism of the COMT gene is associated with increased pain sensitivity in morphin... | DisGeNET | Detail |
The COMT Val158Met polymorphism did not appear to significantly affect susceptibility, symptomatolog... | DisGeNET | Detail |
However, neither allele frequencies of COMT Val158Met nor allele frequencies of DAT1 3'-UTR VNTR wer... | DisGeNET | Detail |
These preliminary results imply that PPI is influenced by COMT Val(158)Met genotype in schizophrenia... | DisGeNET | Detail |
To investigate the involvement of COMT Val158Met and DAT1 3'-UTR VNTR genotypes in the pathogenesis ... | DisGeNET | Detail |
Changes in severity of depression were assessed with weekly Hamilton Depression ratings and analyzed... | DisGeNET | Detail |
The relationship between catechol-O-methyltransferase gene Val158Met (COMT) polymorphism and premorb... | DisGeNET | Detail |
Catechol-O-methyltransferase Val158Met polymorphism and hyperactivity symptoms in Egyptian children ... | DisGeNET | Detail |
The effects of the catechol-O-methyltransferase val158met polymorphism on white matter connectivity ... | DisGeNET | Detail |
In this paper, we review the findings regarding four polymorphisms-MAOA (Monoamine oxidase A) uVNTR,... | DisGeNET | Detail |
Stress reactivity associated with COMT Val158Met in patients with psychosis may crucially depend on ... | DisGeNET | Detail |
Catechol-O-methyltransferase (COMT) val158met polymorphism as a risk factor for PTSD after urban vio... | DisGeNET | Detail |
In the present study, 256 patients with major depression (DSM-IV) of Caucasian descent were genotype... | DisGeNET | Detail |
Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia. | DisGeNET | Detail |
Structural correlates of COMT Val158Met polymorphism in childhood ADHD: a voxel-based morphometry st... | DisGeNET | Detail |
The catechol o-methyltransferase (COMT) val(158)met polymorphism modulates the association of seriou... | DisGeNET | Detail |
Catechol-O-methyltransferase (COMT; Val158Met) and DA D4-receptor (DRD4; 48 bp VNTR) genotypes were ... | DisGeNET | Detail |
We examined 209 Korean schizophrenic patients using the Abnormal Involuntary Movement Scale (AIMS), ... | DisGeNET | Detail |
Has catechol-O-methyltransferase genotype (Val158Met) an influence on endocrine, sympathetic nervous... | DisGeNET | Detail |
We also examined a putative interaction between cannabis and Val(158)Met within the catechol-O-methy... | DisGeNET | Detail |
The COMT rs4680 Met allele contributes to long-lasting low back pain, sciatica and disability after ... | DisGeNET | Detail |
COMT Val158Met-stress interaction in psychosis: role of background psychosis risk. | DisGeNET | Detail |
Differential association of the COMT Val158Met polymorphism with clinical phenotypes in schizophreni... | DisGeNET | Detail |
Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and ... | DisGeNET | Detail |
Functional polymorphisms in the serotonin transporter (5-HTTLPR), catechol-O-methyltransferase (Val1... | DisGeNET | Detail |
COMT Val(158)Met and 5HTTLPR functional loci interact to predict persistence of anxiety across adole... | DisGeNET | Detail |
Sympathetic nervous function and the effect of the catechol-O-methyltransferase Val(158)Met polymorp... | DisGeNET | Detail |
The role of catechol-O-methyltransferase (COMT) val158met in prefrontal cortical deficits associated... | DisGeNET | Detail |
No association between COMT Val158Met polymorphism and prostate cancer risk: a meta-analysis. | DisGeNET | Detail |
Genotyping of rs4680 and rs4818 Catechol-O-Methyltransferase gene polymorphisms was performed on 380... | DisGeNET | Detail |
The Met allele of the functional COMT Val158Met was associated with protection from OD. | DisGeNET | Detail |
To investigate the involvement of COMT Val158Met and DAT1 3'-UTR VNTR genotypes in the pathogenesis ... | DisGeNET | Detail |
A common Val->Met polymorphism (rs4680) in the COMT gene, associated with increased prefrontal do... | DisGeNET | Detail |
In subjects of Afrikaner descent, the L/L genotype of the COMT Val158Met polymorphism was significan... | DisGeNET | Detail |
The paper focuses on such candidate gene polymorphisms that alter alcoholism-related intermediate ph... | DisGeNET | Detail |
There have been several reports on the association between the Val(158)Met genetic polymorphism of t... | DisGeNET | Detail |
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progr... | DisGeNET | Detail |
The Val158Met polymorphism of the COMT (Catechol-O-Methyltransferase) gene, involved in dopamine reg... | DisGeNET | Detail |
Lack of association between COMT Val158Met polymorphism and prostate cancer susceptibility. | DisGeNET | Detail |
Val158Met Polymorphism in catechol-O-methyltransferase gene associated with risk factors for breast ... | DisGeNET | Detail |
In this study, we found that the COMT rs4680 SNP was significantly associated with a reduced risk of... | DisGeNET | Detail |
Previous studies have associated the catechol-O-methyltransferase (COMT) enzyme rs4680 polymorphism ... | DisGeNET | Detail |
In this paper, we review the findings regarding four polymorphisms-MAOA (Monoamine oxidase A) uVNTR,... | DisGeNET | Detail |
Multifactor-dimensionality reduction analysis suggested a two locus model (rs6275/DRD2 and rs4680/CO... | DisGeNET | Detail |
The objective of this study was to determine the potential effects of single nucleotide polymorphism... | DisGeNET | Detail |
In this paper, we review the findings regarding four polymorphisms-MAOA (Monoamine oxidase A) uVNTR,... | DisGeNET | Detail |
Lack of association between the COMT rs4680 polymorphism and ovarian cancer risk: evidence from a me... | DisGeNET | Detail |
Monoamine oxidase A gene promoter (MAOA-uVNTR) and catechol-O-methyltransferase V158M (COMT-V158M) g... | DisGeNET | Detail |
The COMT gene is probably not a gene for any mental disorder, but the Val158Met polymorphism appears... | DisGeNET | Detail |
These exploratory findings suggest that DRD3 Ser9Gly and COMT Val158Met may contribute to pain heter... | DisGeNET | Detail |
One of its most widely studied variations comprises a common single nucleotide polymorphism (SNP), a... | DisGeNET | Detail |
Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorphisms and acute pain... | DisGeNET | Detail |
Since our previous association studies between attention deficit hyperactivity disorder (ADHD) and t... | DisGeNET | Detail |
Asymmetry of prefrontal cortex activities and catechol-O-methyltransferase Val158Met genotype in pat... | DisGeNET | Detail |
Gender-specific association between the COMT Val158Met polymorphism and openness to experience in pa... | DisGeNET | Detail |
The functional Val158Met polymorphism in catechol-O-methyltransferase (COMT) is associated with depr... | DisGeNET | Detail |
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progr... | DisGeNET | Detail |
We sought to determine whether the COMT val158met polymorphism (rs4680) is associated with delusions... | DisGeNET | Detail |
The COMT rs4680 A allele was positively associated with lung cancer in never smokers (for G/A or A/A... | DisGeNET | Detail |
The interaction of early life experiences with COMT val158met affects anxiety sensitivity. | DisGeNET | Detail |
Look beyond Catechol-O-Methyltransferase genotype for cathecolamines derangement in migraine: the Bi... | DisGeNET | Detail |
A valine/methionine polymorphism of the catechol O-methyltransferase gene at amino acid 158 (COMT Va... | DisGeNET | Detail |
In this study, using an epidemiologically-based sample of 130 patients experiencing a first-episode ... | DisGeNET | Detail |
The Val158-allele of the catechol-O-methyltransferase (COMT) Val158Met (rs4680) functional polymorph... | DisGeNET | Detail |
In addition, carriers of the COMT Val(158)Met Val allele were more susceptible to the effect of stre... | DisGeNET | Detail |
A functional interaction between Catechol-O-Methyltransferase (COMT) Val158Met and methylenetetrahyd... | DisGeNET | Detail |
Catechol-O-methyltransferase gene val158met polymorphism and depressive symptoms during early childh... | DisGeNET | Detail |
Contribution of catechol-O-methyltransferase Val158Met polymorphism to endometrial cancer risk in po... | DisGeNET | Detail |
Negative association between catechol-O-methyltransferase (COMT) gene Val158Met polymorphism and per... | DisGeNET | Detail |
The COMT Val(158)Met genotype may moderate the effect of stress on psychotic symptoms. | DisGeNET | Detail |
Evidence from pooled data for genetic association with tardive dyskinesia (TD) showed (1) in COMT(va... | DisGeNET | Detail |
In a cross-sectional study of 396 Caucasian and African-American women, we evaluated whether polymor... | DisGeNET | Detail |
To investigate the involvement of COMT Val158Met and DAT1 3'-UTR VNTR genotypes in the pathogenesis ... | DisGeNET | Detail |
COMT rs4680 genotypes did not have a modifying effect on the association of green tea intake with br... | DisGeNET | Detail |
No association of COMT val158met polymorphism and psychotic symptoms in Lewy body dementias. | DisGeNET | Detail |
Experimental effects of Delta-9-THC on cognition and psychosis are moderated by COMT Val(158)Met gen... | DisGeNET | Detail |
The Met allele of the Catechol-O-Methyltransferase (COMT) gene functional polymorphism (COMT-V158M) ... | DisGeNET | Detail |
We examined 135 breast cancer patients and 107 healthy controls in North Syria to determine the asso... | DisGeNET | Detail |
COMT Val 158 Met polymorphism is related with interpersonal problem solving in schizophrenia. | DisGeNET | Detail |
COMT Val(158)Met moderates the effect of stress on psychotic symptoms. | DisGeNET | Detail |
Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical outcomes in patients ... | DisGeNET | Detail |
A valine-108-methionine polymorphism in exon 4 of the catechol-O-methyltransferase (COMT) gene cause... | DisGeNET | Detail |
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progr... | DisGeNET | Detail |
A total of 11 htSNPs (including COMT Val(158)Met) were selected based on the resequencing and dense ... | DisGeNET | Detail |
Lack of association between the COMT rs4680 polymorphism and ovarian cancer risk: evidence from a me... | DisGeNET | Detail |
The association between headache and Val158Met polymorphism in the catechol-O-methyltransferase gene... | DisGeNET | Detail |
Daytime sleepiness and the COMT val158met polymorphism in patients with Parkinson disease. | DisGeNET | Detail |
COMT Val(158)Met polymorphism has been associated with both symptoms of attention-deficit/hyperactiv... | DisGeNET | Detail |
Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and ... | DisGeNET | Detail |
However, neither allele frequencies of COMT Val158Met nor allele frequencies of DAT1 3'-UTR VNTR wer... | DisGeNET | Detail |
To examine, in a sample of young psychiatric patients, (n = 157, mean age 17.01 years (SD = 3.6)) wh... | DisGeNET | Detail |
The catechol O-methyltransferase Val158Met polymorphism and herpes simplex virus type 1 infection ar... | DisGeNET | Detail |
The data here are consistent with previous work delineating the different symptom subtypes of OCD, a... | DisGeNET | Detail |
This work first showed the association of combined Leu136Leu and Val158Met variants of COMT gene wit... | DisGeNET | Detail |
In a regression model, the number of methionine alleles in COMT val158met was linearly related to pl... | DisGeNET | Detail |
Results show that the COMT rs4680 (val(158)met) polymorphism is most strongly associated with outcom... | DisGeNET | Detail |
Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorphisms and acute pain... | DisGeNET | Detail |
Asymmetry of prefrontal cortex activities and catechol-O-methyltransferase Val158Met genotype in pat... | DisGeNET | Detail |
The val158met polymorphism of human catechol-O-methyltransferase (COMT) affects anterior cingulate c... | DisGeNET | Detail |
A functional polymorphism COMT Val158Met has been associated with psychiatric disorders including su... | DisGeNET | Detail |
Influence of catechol-o-methyltransferase genotype (Val158Met) on endocrine, sympathetic nervous and... | DisGeNET | Detail |
COMT val158met influence on electroconvulsive therapy response in major depression. | DisGeNET | Detail |
Our findings suggest that the Val158Met polymorphism of the COMT gene might contribute to morphologi... | DisGeNET | Detail |
The COMT Val158Met genotype seems to modulate the association between cannabis and age at onset of p... | DisGeNET | Detail |
Association between the COMT Val158Met polymorphism and propensity to anxiety in an Australian popul... | DisGeNET | Detail |
In this study, using an epidemiologically-based sample of 130 patients experiencing a first-episode ... | DisGeNET | Detail |
In this paper, we review the findings regarding four polymorphisms-MAOA (Monoamine oxidase A) uVNTR,... | DisGeNET | Detail |
Contribution of catechol-O-methyltransferase Val158Met polymorphism to endometrial cancer risk in po... | DisGeNET | Detail |
Monoamine oxidase A gene promoter (MAOA-uVNTR) and catechol-O-methyltransferase V158M (COMT-V158M) g... | DisGeNET | Detail |
The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain responses to repeated p... | DisGeNET | Detail |
Our previous work has implicated two genetic factors in the development of cognitive dysfunction in ... | DisGeNET | Detail |
These data suggest that involvement of the COMT locus in susceptibility to anxiety-related traits (i... | DisGeNET | Detail |
No association between COMT Val158Met polymorphism and prostate cancer risk: a meta-analysis. | DisGeNET | Detail |
We analysed the COMT Val158Met polymorphism in 50 patients with chronic schizophrenia randomly alloc... | DisGeNET | Detail |
When MnSOD Ala was combined with either cytochrome P450 1B1 CYP1B1*1 and catechol O-methyltransferas... | DisGeNET | Detail |
Association of COMT Val158Met polymorphism and breast cancer risk: an updated meta-analysis. | DisGeNET | Detail |
The present results provide further support for a-potentially female-specific-role of the COMT val15... | DisGeNET | Detail |
Functional polymorphisms in the serotonin transporter (5-HTTLPR), catechol-O-methyltransferase (Val1... | DisGeNET | Detail |
Association between the COMT Val158Met polymorphism and fibromyalgia susceptibility and fibromyalgia... | DisGeNET | Detail |
COMT Val158Met polymorphism in schizophrenia with obsessive-compulsive disorder: a case-control stud... | DisGeNET | Detail |
[COMT genotype influences the effect of alcohol on blood pressure: results from the COMBINE study.] | DisGeNET | Detail |
Catechol-O-methyltransferase (COMT) gene variants: possible association of the Val158Met variant wit... | DisGeNET | Detail |
The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, that has... | DisGeNET | Detail |
Observational studies have suggested that psychometric psychosis liability and a functional polymorp... | DisGeNET | Detail |
Catechol-O-methyltransferase Val158Met polymorphism and clinical characteristics in first episode no... | DisGeNET | Detail |
Our review examined evidence of an association between the COMT Val(158)Met polymorphism and both ne... | DisGeNET | Detail |
Three common haplotypes of the human COMT gene, divergent in two synonymous and one nonsynonymous (v... | DisGeNET | Detail |
COMT val(158)met genotype and smooth pursuit eye movements in schizophrenia. | DisGeNET | Detail |
64 BD type I patients (39 in manic and 25 in depressive episodes) and 75 healthy controls were genot... | DisGeNET | Detail |
Results show that the COMT rs4680 (val(158)met) polymorphism is most strongly associated with outcom... | DisGeNET | Detail |
Increased catechol-O-methyltransferase activity associated with variation in catechol-O-methyltransf... | DisGeNET | Detail |
The Val158Met polymorphism was more frequent in controls than in PE patients and the placental prese... | DisGeNET | Detail |
The paper focuses on such candidate gene polymorphisms that alter alcoholism-related intermediate ph... | DisGeNET | Detail |
The relationship between catechol-O-methyltransferase gene Val158Met (COMT) polymorphism and premorb... | DisGeNET | Detail |
Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical function in healthy sub... | DisGeNET | Detail |
Association study of COMT gene Val158Met polymorphism with auditory P300 and performance on neurocog... | DisGeNET | Detail |
Effect of the COMT val158met polymorphism on white matter connectivity in patients with major depres... | DisGeNET | Detail |
Intriguingly, in migraine patients, the COMT rs4680 polymorphism influenced headache response to tri... | DisGeNET | Detail |
Because of its role in catecholamine metabolism and several lines of evidence pointing to a locus fo... | DisGeNET | Detail |
The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morph... | DisGeNET | Detail |
Lack of association between COMT Val158Met polymorphism and prostate cancer susceptibility. | DisGeNET | Detail |
The COMT rs4680 A allele was positively associated with lung cancer in never smokers (for G/A or A/A... | DisGeNET | Detail |
Dopamine 2 receptor gene (DRD2) polymorphism C957T (rs6277) and cathechol-o-methyltransferase (COMT)... | DisGeNET | Detail |
Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and ... | DisGeNET | Detail |
This work first showed the association of combined Leu136Leu and Val158Met variants of COMT gene wit... | DisGeNET | Detail |
Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and ... | DisGeNET | Detail |
Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatigue and pain sensitiv... | DisGeNET | Detail |
N = 83 female participants genotyped for COMT Val158Met received 200 mg sulpiride versus placebo and... | DisGeNET | Detail |
COMT-Val158Met-polymorphism is not a risk factor for acute kidney injury after cardiac surgery. | DisGeNET | Detail |
The paper focuses on such candidate gene polymorphisms that alter alcoholism-related intermediate ph... | DisGeNET | Detail |
The functional Val158Met COMT polymorphism appears to affect a host of behaviours mediated by the pr... | DisGeNET | Detail |
Polymorphisms of COMT Val158Met and DAT1 3'-UTR VNTR in illicit drug use and drug-related psychiatri... | DisGeNET | Detail |
In this study we found an association between the val/val genotype of the val158met COMT gene and IB... | DisGeNET | Detail |
The COMT rs4680 Met allele contributes to long-lasting low back pain, sciatica and disability after ... | DisGeNET | Detail |
Association between the COMT Val158Met polymorphism and breast cancer risk: a meta-analysis of 30,19... | DisGeNET | Detail |
Catechol O-methyltransferase Val158Met polymorphism in schizophrenia: differential effects of Val an... | DisGeNET | Detail |
No association of COMT val158met polymorphism and psychotic symptoms in Lewy body dementias. | DisGeNET | Detail |
Because of its role in catecholamine metabolism and several lines of evidence pointing to a locus fo... | DisGeNET | Detail |
We studied the association of the catechol O-methyltransferase (COMT) Val158Met polymorphism and the... | DisGeNET | Detail |
Modulation of brain structure by catechol-O-methyltransferase Val(158) Met polymorphism in chronic c... | DisGeNET | Detail |
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progr... | DisGeNET | Detail |
Influence of catechol-O-methyltransferase Val158Met polymorphism on neuropsychological and functiona... | DisGeNET | Detail |
The Met allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with ... | DisGeNET | Detail |
Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatigue and pain sensitiv... | DisGeNET | Detail |
Evidence that the COMT(Val158Met) polymorphism moderates sensitivity to stress in psychosis: an expe... | DisGeNET | Detail |
Carriers of the COMT Val(158)Met Val allele, but not subjects with the Met/Met genotype, showed an i... | DisGeNET | Detail |
COMT Val158Met polymorphism and breast cancer risk: evidence from 26 case-control studies. | DisGeNET | Detail |
Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and ... | DisGeNET | Detail |
Catechol-O-Methyltransferase (COMT) Val158Met variations and cannabis use in first-episode non-affec... | DisGeNET | Detail |
Combined family trio and case-control analysis of the COMT Val158Met polymorphism in European patien... | DisGeNET | Detail |
The COMT gene Val158Met polymorphism may be a biomarker for phenotypic variation in ASD, but these p... | DisGeNET | Detail |
Catechol-O-methyltransferase Val158Met polymorphism affects therapeutic response to mood stabilizer ... | DisGeNET | Detail |
Variation in the catechol-O-methyltransferase Val 158 Met polymorphism associated with conduct disor... | DisGeNET | Detail |
Evidence that the COMT(Val158Met) polymorphism moderates sensitivity to stress in psychosis: an expe... | DisGeNET | Detail |
Association between the catechol-O-methyltransferase Val158Met polymorphism and panic disorder: a re... | DisGeNET | Detail |
Our objectives were (1) to examine how baseline stress and change in stress is associated with cours... | DisGeNET | Detail |
In the present study, we analyzed the interaction between pharmacological treatment (clozapine vs ty... | DisGeNET | Detail |
Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress... | DisGeNET | Detail |
These exploratory findings suggest that DRD3 Ser9Gly and COMT Val158Met may contribute to pain heter... | DisGeNET | Detail |
COMT Val158Met had an effect on Neuroticism in females by age 25 (p=0.001, Bonferroni-corrected for ... | DisGeNET | Detail |
While it cannot be determined whether TBI influenced the association of COMT Val158Met to executive ... | DisGeNET | Detail |
COMT Val158met polymorphism was genotyped in 334 Chinese major depressive disorder (MDD) patients wh... | DisGeNET | Detail |
COMT Val158Met polymorphism and socioeconomic status interact to predict attention deficit/hyperacti... | DisGeNET | Detail |
A putative interaction between cannabis and variation at rs4680 within the catechol-methyl-transfera... | DisGeNET | Detail |
Lack of influence of COMT Val158Met genotype on cognition in first-episode non-affective psychosis. | DisGeNET | Detail |
Catechol O-methyltransferase (COMT), the major enzyme determining cortical dopamine flux, has a comm... | DisGeNET | Detail |
Our results indicate that genotyping for COMT rs4680 and SLC6A4 STin2 VNTR could be useful for the i... | DisGeNET | Detail |
The meta-analyses showed that fibromyalgia or chronic widespread pain is the only type of chronic pa... | DisGeNET | Detail |
COMT Val158met polymorphism was genotyped in 334 Chinese major depressive disorder (MDD) patients wh... | DisGeNET | Detail |
Catechol-O-methyltransferase Val158Met polymorphism and negative symptoms after acute antipsychotic ... | DisGeNET | Detail |
Effects of the val(158)met catechol-O-methyltransferase gene polymorphism on olfactory processing in... | DisGeNET | Detail |
We examined 135 breast cancer patients and 107 healthy controls in North Syria to determine the asso... | DisGeNET | Detail |
Sex differences in the influence of COMT Val158Met on alcoholism and smoking in plains American Indi... | DisGeNET | Detail |
Differential association of the COMT Val158Met polymorphism with clinical phenotypes in schizophreni... | DisGeNET | Detail |
The relationship between the val158met catechol-O-methyltransferase (COMT) polymorphism and irritabl... | DisGeNET | Detail |
Results indicate a main as well as a GxE effect of the COMT Val158Met variant and childhood maltreat... | DisGeNET | Detail |
Our results indicate that genotyping for COMT rs4680 and SLC6A4 STin2 VNTR could be useful for the i... | DisGeNET | Detail |
Polymorphisms of COMT Val158Met and DAT1 3'-UTR VNTR in illicit drug use and drug-related psychiatri... | DisGeNET | Detail |
Functional polymorphisms in the MAO-A uVNTR promoter gene, the COMT gene (Val158Met) exon 4, and the... | DisGeNET | Detail |
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progr... | DisGeNET | Detail |
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progr... | DisGeNET | Detail |
There have been several reports on the association between the Val(158)Met genetic polymorphism of t... | DisGeNET | Detail |
We examined 87 cases and 341 population controls in Taiwan to determine the association between the ... | DisGeNET | Detail |
Their presence may be correlated with cognitive impairment; however, the relationship between region... | DisGeNET | Detail |
Our objectives were (1) to examine how baseline stress and change in stress is associated with cours... | DisGeNET | Detail |
Catechol-O-methyltransferase (COMT) val(108/158)met (rs4680) is thought to affect dopamine regulated... | DisGeNET | Detail |
Meta-analysis of COMT val158met in panic disorder: ethnic heterogeneity and gender specificity. | DisGeNET | Detail |
Our previous work has implicated two genetic factors in the development of cognitive dysfunction in ... | DisGeNET | Detail |
Role of the COMT gene Val158Met polymorphism in mental disorders: a review. | DisGeNET | Detail |
Many of these differences are unconfirmed or minor, but some appear to be of reasonable robustness a... | DisGeNET | Detail |
Catechol-O-methyltransferase Val158Met polymorphism (rs4680) is associated with pain in multiple scl... | DisGeNET | Detail |
Influence of the catechol-O-methyltransferase val158met genotype on amygdala and prefrontal cortex e... | DisGeNET | Detail |
Catechol-o-methyltransferase valine(158)methionine genotype and resting regional cerebral blood flow... | DisGeNET | Detail |
It is shown that a polymorphism in the COMT gene, Rs4680 (Val158Met), influence pain sensitivity in ... | DisGeNET | Detail |
When MnSOD Ala was combined with either cytochrome P450 1B1 CYP1B1*1 and catechol O-methyltransferas... | DisGeNET | Detail |
The catechol O-methyltransferase Val158Met polymorphism and herpes simplex virus type 1 infection ar... | DisGeNET | Detail |
A valine-108-methionine polymorphism in exon 4 of the catechol-O-methyltransferase (COMT) gene cause... | DisGeNET | Detail |
This study highlights the importance of COMT rs4680 in influencing the clinical response to drugs us... | DisGeNET | Detail |
The present results provide further support for a-potentially female-specific-role of the COMT val15... | DisGeNET | Detail |
The functional polymorphism of the catecholamine-O-methyl-transferase (COMT) gene Val158Met signific... | DisGeNET | Detail |
When we corrected for multiple testing using these statistical tools, three novel associations of NS... | DisGeNET | Detail |
When we corrected for multiple testing using these statistical tools, three novel associations of NS... | DisGeNET | Detail |
Although CYP1B1 and COMT genotypes did not exhibit statistically significant association with breast... | DisGeNET | Detail |
Although CYP1B1 and COMT genotypes did not exhibit statistically significant association with breast... | DisGeNET | Detail |
Gene-gene interaction analysis revealed significant additive effect of DBH rs1108580 and DRD4 rs1800... | DisGeNET | Detail |
Gene-gene interaction analysis revealed significant additive effect of DBH rs1108580 and DRD4 rs1800... | DisGeNET | Detail |
Pairwise analysis showed that combinations of the ERalpha G allele with the homozygous Trp genotype ... | DisGeNET | Detail |
Overlapped Transcript Coordinates
Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
---|
Overlapped Transcript
Gene | Transcript ID | Chromosome | Start | Stop | Links |
---|
- Gene
- -
- dbSNP
- rs4680 dbSNP
- Genome
- hg38
- Position
- chr22:19,963,748-19,963,748
- Variant Type
- snv
- Reference Allele
- G
- Alternative Allele
- A
- Filtering Status (HGVD)
- PASS
- # of samples (HGVD)
- 1202
- Mean of sample read depth (HGVD)
- 55.85
- Standard deviation of sample read depth (HGVD)
- 27.78
- Number of reference allele (HGVD)
- 1659
- Number of alternative allele (HGVD)
- 745
- Allele Frequency (HGVD)
- 0.3099001663893511
- Gene Symbol (HGVD)
- COMT
- ToMMo VCF FILTER column value (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
- PASS
- Total VCF ID column value (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
- rs4680
- Allele frequency, for each ALT allele (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
- 0.3173
- Allele count in genotypes, for each ALT allele (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
- 5318
- Total number of alleles in called genotypes (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
- 16760
- East Asian Chromosome Counts (ExAC)
- 8314
- East Asian Allele Counts (ExAC)
- 2369
- East Asian Heterozygous Counts (ExAC)
- 1715
- East Asian Homozygous Counts (ExAC)
- 327
- East Asian Allele Frequency (ExAC)
- 0.2849410632667789
- Chromosome Counts in All Race (ExAC)
- 117012
- Allele Counts in All Race (ExAC)
- 55317
- Heterozygous Counts in All Race (ExAC)
- 28887
- Homozygous Counts in All Race (ExAC)
- 13215
- Allele Frequency in All Race (ExAC)
- 0.4727463849861553
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