Annotation Detail
Information
- Associated Genes
- COMT
- Associated Variants
-
rs737865
(
ENST00000361682.11,
ENST00000403184.5,
ENST00000403710.5,
ENST00000407537.5,
ENST00000428707.2,
ENST00000676678.1,
ENST00000678769.1,
ENST00000678868.1 )
COMT p.Val158Met (p.V158M) ( ENST00000361682.11, ENST00000403184.5, ENST00000403710.5, ENST00000406520.7, ENST00000407537.5, ENST00000428707.2, ENST00000449653.5, ENST00000676678.1, ENST00000678255.1, ENST00000678769.1, ENST00000678868.1 )
COMT c.*522G>A ( ENST00000361682.11, ENST00000678255.1, ENST00000678769.1, ENST00000678868.1 )
rs737865 ( ENST00000361682.11, ENST00000403184.5, ENST00000403710.5, ENST00000407537.5, ENST00000428707.2, ENST00000676678.1, ENST00000678769.1, ENST00000678868.1 )
COMT p.Val158Met (p.V158M) ( ENST00000361682.11, ENST00000403184.5, ENST00000403710.5, ENST00000406520.7, ENST00000407537.5, ENST00000428707.2, ENST00000449653.5, ENST00000676678.1, ENST00000678255.1, ENST00000678769.1, ENST00000678868.1 )
COMT c.*522G>A ( ENST00000361682.11, ENST00000678255.1, ENST00000678769.1, ENST00000678868.1 ) - Associated Disease
- schizophrenia
- Source Database
- DisGeNET
- Description
- We find that P50 and PPI may be influenced by COMT rs4680 polymorphisms in schizophrenia; more excitingly, we find that P50 might be influenced by COMT rs737865 polymorphisms and PPI may be influenced by COMT rs165599 polymorphisms in schizophrenia, and their mutations are associated with the reduction of the risk of P50 or PPI defects in schizophrenia.
- Pubmed
- 23598060
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.345417491171353
- Year of publication
- 2013
Drugs