chr22:19951271:G>A Detail (hg19) (COMT)

Information

Genome

Assembly Position
hg19 chr22:19,951,271-19,951,271
hg38 chr22:19,963,748-19,963,748 View the variant detail on this assembly version.

HGVS

Type Transcript Protein
RefSeq NM_000754.3:c.472G>A NP_000745.1:p.Val158Met
NM_001135162.1:c.472G>A NP_001128634.1:p.Val158Met
NM_007310.2:c.322G>A NP_009294.1:p.Val108Met
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

JP HGVD:0.310
ToMMo:0.317
NCBN:[No Data.]
NCBN(Hondo):[No Data.]
NCBN(Ryukyu):[No Data.]
East asia ExAC:0.285

Prediction

ClinVar

Clinical Significance Benign
Review star
Show details
Links
Type Database ID Link
Gene MIM 116790 OMIM
HGNC 2228 HGNC
Ensembl ENSG00000093010 Ensembl
NCBI NCBI
Gene Cards Gene Cards
OncoKB OncoKB
Type Database ID Link
Variant TogoVar tgv65380347 TogoVar
COSMIC
MONDO
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
Clinical significance Last evaluated Review status Condition Origin Links
Benign 2011-01-01 no assertion criteria provided CATECHOL-O-METHYLTRANSFERASE POLYMORPHISM germline Detail
Benign criteria provided, single submitter not specified germline Detail
drug response 2018-04-28 no assertion criteria provided somatic Detail
Benign criteria provided, single submitter schizophrenia germline Detail
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.033 breast carcinoma Pairwise analysis showed that combinations of the ERalpha G allele with the homo... BeFree 18820009 Detail
0.345 schizophrenia Our results demonstrated initial significant associations of two SNPs for DRD2 (... BeFree 19207030 Detail
0.240 Malignant neoplasm of breast Pairwise analysis showed that combinations of the ERalpha G allele with the homo... BeFree 18820009 Detail
0.080 breast carcinoma Pairwise analysis showed that combinations of the ERalpha G allele with the homo... BeFree 18820009 Detail
<0.001 Chronic Kidney Diseases The Chi-square test, multivariable logistic regression analysis with adjustment ... BeFree 19578796 Detail
0.001 Chronic Kidney Diseases The Chi-square test, multivariable logistic regression analysis with adjustment ... BeFree 19578796 Detail
<0.001 Chronic Kidney Diseases The Chi-square test, multivariable logistic regression analysis with adjustment ... BeFree 19578796 Detail
0.127 major depressive disorder To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.082 depressive disorder To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.026 Mental Depression To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.002 Unipolar Depression To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.013 Mental Depression To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.006 depressive disorder To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.088 depressive disorder To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.018 Mental Depression To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.087 depressive disorder To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.002 depressive disorder To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.003 major depressive disorder To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.004 Unipolar Depression To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.020 Mental Depression To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.009 depressive disorder To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.033 Mental Depression To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.006 depressive disorder To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.038 Mental Depression To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.009 Mental Depression To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.043 Mental Depression To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.007 depressive disorder To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.020 panic disorder Nine gene-candidates, including 5-HTTLPR, MAO-A VNTR, TPH2 rs1386494, 5-HTR1A -1... BeFree 18832011 Detail
0.005 PANIC DISORDER 1 Nine gene-candidates, including 5-HTTLPR, MAO-A VNTR, TPH2 rs1386494, 5-HTR1A -1... BeFree 18832011 Detail
0.002 PANIC DISORDER 1 Nine gene-candidates, including 5-HTTLPR, MAO-A VNTR, TPH2 rs1386494, 5-HTR1A -1... BeFree 18832011 Detail
0.162 panic disorder Nine gene-candidates, including 5-HTTLPR, MAO-A VNTR, TPH2 rs1386494, 5-HTR1A -1... BeFree 18832011 Detail
0.178 attention deficit hyperactivity disorder We genotyped a sample of 45 adults with ADHD at four candidate polymorphisms for... BeFree 17886261 Detail
<0.001 attention deficit hyperactivity disorder We genotyped a sample of 45 adults with ADHD at four candidate polymorphisms for... BeFree 17886261 Detail
0.329 attention deficit hyperactivity disorder We genotyped a sample of 45 adults with ADHD at four candidate polymorphisms for... BeFree 17886261 Detail
0.340 attention deficit hyperactivity disorder We genotyped a sample of 45 adults with ADHD at four candidate polymorphisms for... BeFree 17886261 Detail
<0.001 epilepsy Stage 1 analysis included 290 patients with epilepsy and revealed a higher load ... BeFree 22881836 Detail
<0.001 epilepsy Stage 1 analysis included 290 patients with epilepsy and revealed a higher load ... BeFree 22881836 Detail
0.345 schizophrenia We find that P50 and PPI may be influenced by COMT rs4680 polymorphisms in schiz... BeFree 23598060 Detail
0.345 schizophrenia A common functional polymorphism, Val108/158Met (rs4680), and haplotypes rs73786... BeFree 19329282 Detail
0.012 schizophrenia We find that P50 and PPI may be influenced by COMT rs4680 polymorphisms in schiz... BeFree 23598060 Detail
<0.001 Opiate Addiction To determine whether COMT is important in substance dependence, rs165774 and rs4... BeFree 22208661 Detail
0.345 schizophrenia It is possible that the rs165774 SNP, in combination with rs4680, results in a c... BeFree 22208661 Detail
0.122 DiGeorge syndrome The increased volumes in the genu, splenium and total CC in the 22q11DS group we... BeFree 22763378 Detail
0.121 Shprintzen syndrome The increased volumes in the genu, splenium and total CC in the 22q11DS group we... BeFree 22763378 Detail
0.280 DiGeorge syndrome The increased volumes in the genu, splenium and total CC in the 22q11DS group we... BeFree 22763378 Detail
0.135 Shprintzen syndrome The increased volumes in the genu, splenium and total CC in the 22q11DS group we... BeFree 22763378 Detail
<0.001 Shprintzen syndrome The increased volumes in the genu, splenium and total CC in the 22q11DS group we... BeFree 22763378 Detail
<0.001 DiGeorge syndrome The increased volumes in the genu, splenium and total CC in the 22q11DS group we... BeFree 22763378 Detail
0.014 endometrial carcinoma Patients with EH (n = 89), EH concurrent with ECa (n = 76), ECa (n = 186), and h... BeFree 25741405 Detail
<0.001 endometrial hyperplasia Patients with EH (n = 89), EH concurrent with ECa (n = 76), ECa (n = 186), and h... BeFree 25741405 Detail
<0.001 Flushing Functional alleles that alter alcoholism-related intermediate phenotypes include... BeFree 15584875 Detail
0.011 Flushing Functional alleles that alter alcoholism-related intermediate phenotypes include... BeFree 15584875 Detail
<0.001 Dysphoric mood Functional alleles that alter alcoholism-related intermediate phenotypes include... BeFree 15584875 Detail
0.347 Alcoholic Intoxication, Chronic Functional alleles that alter alcoholism-related intermediate phenotypes include... BeFree 15584875 Detail
0.159 Alcoholic Intoxication, Chronic Functional alleles that alter alcoholism-related intermediate phenotypes include... BeFree 15584875 Detail
<0.001 Dysphoric mood Functional alleles that alter alcoholism-related intermediate phenotypes include... BeFree 15584875 Detail
0.001 Anxiety Disorders Functional alleles that alter alcoholism-related intermediate phenotypes include... BeFree 15584875 Detail
0.157 Alcoholic Intoxication, Chronic Functional alleles that alter alcoholism-related intermediate phenotypes include... BeFree 15584875 Detail
<0.001 Anxiety Disorders Functional alleles that alter alcoholism-related intermediate phenotypes include... BeFree 15584875 Detail
0.017 Anxiety Disorders Functional alleles that alter alcoholism-related intermediate phenotypes include... BeFree 15584875 Detail
0.001 Nonorganic psychosis Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) po... BeFree 18351593 Detail
<0.001 Bulimia We explored the influence of interactions between polymorphisms acting upon post... BeFree 22683321 Detail
0.004 nicotine dependence Age, gender, Fagerström Test for Nicotine Dependence, dopamine pathway genotypes... BeFree 23941313 Detail
<0.001 Eating Disorders We explored the influence of interactions between polymorphisms acting upon post... BeFree 22683321 Detail
<0.001 Bulimia We explored the influence of interactions between polymorphisms acting upon post... BeFree 22683321 Detail
0.003 Bulimia We explored the influence of interactions between polymorphisms acting upon post... BeFree 22683321 Detail
0.004 Psychotic Disorders Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) po... BeFree 18351593 Detail
0.001 Eating Disorders We explored the influence of interactions between polymorphisms acting upon post... BeFree 22683321 Detail
0.006 Psychotic Disorders Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) po... BeFree 18351593 Detail
0.006 Eating Disorders We explored the influence of interactions between polymorphisms acting upon post... BeFree 22683321 Detail
0.003 Nonorganic psychosis Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) po... BeFree 18351593 Detail
0.003 Eating Disorders We explored the influence of interactions between polymorphisms acting upon post... BeFree 22683321 Detail
0.003 Bulimia We explored the influence of interactions between polymorphisms acting upon post... BeFree 22683321 Detail
0.012 Nonorganic psychosis Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) po... BeFree 18351593 Detail
0.032 Psychotic Disorders Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) po... BeFree 18351593 Detail
0.003 Impaired cognition The investigation of the catechol-O-methyltransferase (COMT-[rs4680]) and methyl... BeFree 23353103 Detail
0.003 Impaired cognition The investigation of the catechol-O-methyltransferase (COMT-[rs4680]) and methyl... BeFree 23353103 Detail
<0.001 adenocarcinoma The G/G homozygous genotype in COMT rs4680 and A/A homozygous genotype in PLCH1 ... BeFree 22658813 Detail
<0.001 squamous cell carcinoma The G/G homozygous genotype in COMT rs4680 and A/A homozygous genotype in PLCH1 ... BeFree 22658813 Detail
0.101 Malignant neoplasm of breast However, when this relation was assessed within strata based on estrogen-related... BeFree 22199302 Detail
0.240 Malignant neoplasm of breast However, when this relation was assessed within strata based on estrogen-related... BeFree 22199302 Detail
0.028 Malignant neoplasm of breast However, when this relation was assessed within strata based on estrogen-related... BeFree 22199302 Detail
0.005 Mammographic Density However, when this relation was assessed within strata based on estrogen-related... BeFree 22199302 Detail
0.003 Mammographic Density However, when this relation was assessed within strata based on estrogen-related... BeFree 22199302 Detail
0.080 breast carcinoma However, when this relation was assessed within strata based on estrogen-related... BeFree 22199302 Detail
0.004 breast carcinoma However, when this relation was assessed within strata based on estrogen-related... BeFree 22199302 Detail
0.003 Mammographic Density However, when this relation was assessed within strata based on estrogen-related... BeFree 22199302 Detail
0.021 breast carcinoma However, when this relation was assessed within strata based on estrogen-related... BeFree 22199302 Detail
0.004 breast carcinoma However, when this relation was assessed within strata based on estrogen-related... BeFree 22199302 Detail
0.006 Mammographic Density However, when this relation was assessed within strata based on estrogen-related... BeFree 22199302 Detail
0.042 Malignant neoplasm of breast However, when this relation was assessed within strata based on estrogen-related... BeFree 22199302 Detail
0.097 Malignant neoplasm of breast We examined the potential association of breast cancer risk in Mexican women wit... BeFree 23000097 Detail
0.001 Uterine Fibroids The genetic polymorphism of rs3087869 (IVS1+2329C&gt;T) (OR 3.200, 95% CI 1.614-... BeFree 24777039 Detail
0.104 Malignant neoplasm of breast We examined the potential association of breast cancer risk in Mexican women wit... BeFree 23000097 Detail
0.101 Malignant neoplasm of breast We examined the potential association of breast cancer risk in Mexican women wit... BeFree 23000097 Detail
0.102 Malignant neoplasm of breast We examined the potential association of breast cancer risk in Mexican women wit... BeFree 23000097 Detail
0.017 breast carcinoma We examined the potential association of breast cancer risk in Mexican women wit... BeFree 23000097 Detail
0.002 Uterine Fibroids The genetic polymorphism of rs3087869 (IVS1+2329C&gt;T) (OR 3.200, 95% CI 1.614-... BeFree 24777039 Detail
0.021 breast carcinoma We examined the potential association of breast cancer risk in Mexican women wit... BeFree 23000097 Detail
0.001 Uterine Fibroids The genetic polymorphisms of IVS1+2329C&gt;T and Val158Met loci in COMT, Ile462V... BeFree 24320736 Detail
0.002 Uterine Fibroids The genetic polymorphisms of IVS1+2329C&gt;T and Val158Met loci in COMT, Ile462V... BeFree 24320736 Detail
0.016 breast carcinoma We examined the potential association of breast cancer risk in Mexican women wit... BeFree 23000097 Detail
0.096 Malignant neoplasm of breast We examined the potential association of breast cancer risk in Mexican women wit... BeFree 23000097 Detail
0.024 breast carcinoma We examined the potential association of breast cancer risk in Mexican women wit... BeFree 23000097 Detail
0.004 Uterine Fibroids The genetic polymorphism of rs3087869 (IVS1+2329C&gt;T) (OR 3.200, 95% CI 1.614-... BeFree 24777039 Detail
0.019 breast carcinoma We examined the potential association of breast cancer risk in Mexican women wit... BeFree 23000097 Detail
0.099 Malignant neoplasm of breast We examined the potential association of breast cancer risk in Mexican women wit... BeFree 23000097 Detail
0.022 breast carcinoma We examined the potential association of breast cancer risk in Mexican women wit... BeFree 23000097 Detail
0.004 Uterine Fibroids The genetic polymorphisms of IVS1+2329C&gt;T and Val158Met loci in COMT, Ile462V... BeFree 24320736 Detail
0.345 schizophrenia We assessed catechol-O-methyltransferase (COMT) Val108/158Met (rs4680) and dopam... BeFree 24495967 Detail
0.291 schizophrenia We assessed catechol-O-methyltransferase (COMT) Val108/158Met (rs4680) and dopam... BeFree 24495967 Detail
0.007 Marijuana Abuse Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms ... BeFree 24407958 Detail
0.014 Marijuana Abuse Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms ... BeFree 24407958 Detail
<0.001 Marijuana Abuse Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms ... BeFree 24407958 Detail
0.002 Marijuana Abuse Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms ... BeFree 24407958 Detail
0.006 Marijuana Abuse Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms ... BeFree 24407958 Detail
0.003 Marijuana Abuse Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms ... BeFree 24407958 Detail
0.120 Mental Depression Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158... BeFree 17941097 Detail
0.002 Chronic pain However, genetic effects (COMT Val(158)Met and BDNF Val(66)Met) on experimental ... BeFree 21049025 Detail
0.009 depressive disorder Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158... BeFree 17941097 Detail
0.017 Anxiety Disorders Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxi... BeFree 19582565 Detail
0.248 depressive disorder Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158... BeFree 17941097 Detail
0.001 Autism Spectrum Disorders Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxi... BeFree 19582565 Detail
0.038 Mental Depression Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158... BeFree 17941097 Detail
0.006 Cognitive changes Patients were also genotyped for three polymorphisms associated with cognitive c... BeFree 25080285 Detail
<0.001 Cognitive changes Patients were also genotyped for three polymorphisms associated with cognitive c... BeFree 25080285 Detail
<0.001 Cognitive changes Patients were also genotyped for three polymorphisms associated with cognitive c... BeFree 25080285 Detail
0.104 Malignant neoplasm of breast Results from this study suggest that rs4680 in the COMT gene and rs4646903 in th... BeFree 17429315 Detail
0.024 breast carcinoma Results from this study suggest that rs4680 in the COMT gene and rs4646903 in th... BeFree 17429315 Detail
0.101 Malignant neoplasm of breast Results from this study suggest that rs4680 in the COMT gene and rs4646903 in th... BeFree 17429315 Detail
0.021 breast carcinoma Results from this study suggest that rs4680 in the COMT gene and rs4646903 in th... BeFree 17429315 Detail
<0.001 Phobic anxiety disorder Functional polymorphisms in the MAO-A uVNTR promoter gene, the COMT gene (Val158... BeFree 15450911 Detail
0.023 fibromyalgia Catechol-O-methyltransferase Val158Met polymorphism influences anxiety, depressi... BeFree 23025981 Detail
0.124 22q11 Deletion Syndrome COMT Val(158) met genotype and striatal D(2/3) receptor binding in adults with 2... BeFree 21465565 Detail
0.001 post-traumatic stress disorder Catechol-O-methyltransferase Val158Met polymorphism moderates anterior cingulate... BeFree 21783175 Detail
0.034 obsessive-compulsive disorder Many of these differences are unconfirmed or minor, but some appear to be of rea... BeFree 17805313 Detail
0.162 panic disorder Only Val158Met polymorphism of the catechol-O-methyltransferase gene has been im... BeFree 20048750 Detail
0.124 Anxiety Disorders The paper focuses on such candidate gene polymorphisms that alter alcoholism-rel... BeFree 17079080 Detail
0.016 major depressive disorder We investigated the associations between COMT Val(158)Met and depression in a Sw... BeFree 20828831 Detail
0.032 Psychotic Disorders In addition, carriers of the COMT Val(158)Met Val allele were more susceptible t... BeFree 17640440 Detail
0.005 PANIC DISORDER 1 Sympathetic nervous function and the effect of the catechol-O-methyltransferase ... BeFree 19900710 Detail
0.002 Uterine Fibroids The associations between the Val158Met in the catechol-O-methyltransferase (COMT... BeFree 23939469 Detail
<0.001 female breast carcinoma We examined 87 cases and 341 population controls in Taiwan to determine the asso... BeFree 16191465 Detail
0.009 depressive disorder The functional Val158Met polymorphism in catechol-O-methyltransferase (COMT) is ... BeFree 20828831 Detail
0.157 Alcoholic Intoxication, Chronic Reduced dopamine receptor sensitivity as an intermediate phenotype in alcohol de... BeFree 22474103 Detail
0.082 attention deficit hyperactivity disorder We studied the association of the catechol O-methyltransferase (COMT) Val158Met ... BeFree 20868372 Detail
0.032 Psychotic Disorders Our review examined evidence of an association between the COMT Val(158)Met poly... BeFree 23527885 Detail
0.345 schizophrenia No association found between 158 Val/Met polymorphism of the COMT gene and schiz... BeFree 16109444 Detail
0.345 schizophrenia Cannabis use profiles and COMT Val158Met genotypes were obtained from 80 inpatie... BeFree 21231925 Detail
0.280 DiGeorge syndrome [The effects of gender and catechol O-methyltransferase (COMT) Val108/158Met pol... GAD 20123031 Detail
<0.001 Drug withdrawal syndrome Our results indicate that genotyping for COMT rs4680 and SLC6A4 STin2 VNTR could... BeFree 24684248 Detail
0.019 lingual-facial-buccal dyskinesia Evidence from pooled data for genetic association with tardive dyskinesia (TD) s... BeFree 18180754 Detail
0.017 Anxiety Disorders Association of the catechol-O-methyltransferase val158met polymorphism and anxie... BeFree 24300663 Detail
0.181 bipolar disorder This work first showed the association of combined Leu136Leu and Val158Met varia... BeFree 25766270 Detail
0.002 nicotine dependence The catechol-O-methyltransferase (COMT) Val158Met polymorphism may be a risk fac... BeFree 23459442 Detail
0.023 fibromyalgia Clinical symptoms in fibromyalgia are associated to catechol-O-methyltransferase... BeFree 24762091 Detail
0.345 schizophrenia Catechol-O-methyltransferase Val158Met polymorphism in relation to aggressive sc... BeFree 18789857 Detail
<0.001 Drug withdrawal syndrome Our results indicate that genotyping for COMT rs4680 and SLC6A4 STin2 VNTR could... BeFree 24684248 Detail
0.002 nicotine dependence The common methionine (met) for valine (val) at codon 158 (val(158)met) polymorp... BeFree 23828159 Detail
0.345 schizophrenia No association between the Catechol-O-Methyltransferase (COMT) val158met polymor... BeFree 21458532 Detail
0.345 schizophrenia Interaction between catechol-O-methyltransferase (COMT) Val158Met genotype and g... BeFree 22617427 Detail
0.034 obsessive-compulsive disorder In subjects of Afrikaner descent, the L/L genotype of the COMT Val158Met polymor... BeFree 16187774 Detail
0.003 Herpes Simplex Infections Both the COMT Val158Met polymorphism and serological evidence of HSV-1 infection... BeFree 16542182 Detail
0.003 schizophrenia Here, we report the investigation of the differential activity of membrane-bound... BeFree 16984965 Detail
0.002 Unipolar Depression Dopamine 2 receptor gene (DRD2) polymorphism C957T (rs6277) and cathechol-o-meth... BeFree 18929622 Detail
0.012 Nonorganic psychosis Carriers of the COMT Val(158)Met Val allele, but not subjects with the Met/Met g... BeFree 18808401 Detail
<0.001 Mental disorders Polymorphisms of COMT Val158Met and DAT1 3'-UTR VNTR in illicit drug use and dru... BeFree 24708432 Detail
0.021 breast carcinoma Association of COMT Val158Met polymorphism and breast cancer risk: an updated me... BeFree 23039364 Detail
0.345 schizophrenia Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical fun... BeFree 19666577 Detail
0.058 Malignant neoplasm of prostate The Val158Met polymorphism of the catechol-O-methyltransferase gene is associate... BeFree 16126332 Detail
0.058 Malignant neoplasm of prostate The Val158Met polymorphism of the catechol-O-methyltransferase gene is associate... BeFree 16126332 Detail
0.012 Nonorganic psychosis Cannabis use and age at onset of psychosis: further evidence of interaction with... BeFree 21231925 Detail
0.017 Anxiety Disorders The present results provide further support for a-potentially female-specific-ro... BeFree 22387174 Detail
0.001 post-traumatic stress disorder The risk of posttraumatic stress disorder after trauma depends on traumatic load... BeFree 19944409 Detail
0.012 Nonorganic psychosis The aim of the study was to evaluate the influence of COMT Val158Met polymorphis... BeFree 18092319 Detail
0.005 osteochondritis dissecans These results do not support the hypothesis that the COMT Val158Met gene polymor... BeFree 16043283 Detail
0.162 panic disorder Gender-specific association between the COMT Val158Met polymorphism and openness... BeFree 24852514 Detail
0.002 borderline personality disorder The catechol o-methyltransferase (COMT) val(158)met polymorphism modulates the a... BeFree 19906087 Detail
<0.001 Chronic tension-type headache Genetic contribution of catechol-O-methyltransferase polymorphism (Val158Met) in... BeFree 21691248 Detail
0.017 Anxiety Disorders A coding variant in one such gene, encoding the dopamine catabolic enzyme catech... BeFree 18729643 Detail
0.157 Alcoholic Intoxication, Chronic [We evaluated the association of COMT genotype at this locus with blood pressure... GAD 19023276 Detail
0.004 MAJOR AFFECTIVE DISORDER 8 Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han C... BeFree 9352569 Detail
0.264 Anxiety Disorders The paper focuses on such candidate gene polymorphisms that alter alcoholism-rel... BeFree 17079080 Detail
0.016 major depressive disorder Association of the COMT val158met variant with antidepressant treatment response... BeFree 17522626 Detail
0.181 bipolar disorder The impact of the Val158Met catechol-O-methyltransferase genotype on neural corr... BeFree 20667170 Detail
0.034 obsessive-compulsive disorder The data here are consistent with previous work delineating the different sympto... BeFree 19398820 Detail
0.002 Malignant neoplasm of endometrium Contribution of catechol-O-methyltransferase Val158Met polymorphism to endometri... BeFree 24390993 Detail
<0.001 Apathy Our study indicates an association between rs4680, an SNP in the COMT gene, and ... BeFree 23769684 Detail
0.012 Nonorganic psychosis A putative interaction between cannabis and variation at rs4680 within the catec... BeFree 21947654 Detail
0.001 Memory impairment The COMT val(158)met polymorphism was associated with abstinence-related working... BeFree 23828159 Detail
0.003 Hot flushes Compared with nonsmokers, European-American COMT Val158Met double-variant carrie... BeFree 22466345 Detail
0.093 Hypertensive disease Previous studies of a functional variant of the catechol-O-methyl transferase (C... BeFree 21776034 Detail
0.345 schizophrenia Effect of catechol O-methyltransferase val(158)met polymorphism on the p50 gatin... BeFree 17448448 Detail
0.001 irritable bowel syndrome Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in i... BeFree 23110189 Detail
0.008 Unipolar Depression Association of the COMT val158met variant with antidepressant treatment response... BeFree 17522626 Detail
0.014 Marijuana Abuse Catechol-O-Methyltransferase (COMT) Val158Met variations and cannabis use in fir... BeFree 20493536 Detail
0.157 Alcoholic Intoxication, Chronic COMT Val158Met modulates the effect of childhood adverse experiences on the risk... BeFree 22509987 Detail
0.178 attention deficit hyperactivity disorder This study aimed to derive a comprehensive, whole-brain characterization of larg... BeFree 25201318 Detail
0.345 schizophrenia COMT Val 158 Met polymorphism is associated with cognitive flexibility in a sign... BeFree 19585392 Detail
0.004 Carcinogenesis To better evaluate the role of COMT Val158Met in endometrial carcinogenesis, we ... BeFree 24390993 Detail
0.345 schizophrenia Moreover, variations in the COMT Val158Met functional polymorphism have been ass... BeFree 18407467 Detail
0.014 Mood Disorders Association of the COMT synonymous polymorphism Leu136Leu and missense variant V... BeFree 25766270 Detail
<0.001 Obesity, Abdominal Catechol O-methyltransferase val158-met polymorphism is associated with abdomina... BeFree 18442637 Detail
<0.001 Delusions We sought to determine whether the COMT val158met polymorphism (rs4680) is assoc... BeFree 23069674 Detail
<0.001 Phobic anxiety disorder Functional polymorphisms in the MAO-A uVNTR promoter gene, the COMT gene (Val158... BeFree 15450911 Detail
0.204 Alcoholic Intoxication, Chronic This study tested the hypothesis that genetic variation in COMT Val158Met and DR... BeFree 22509987 Detail
0.345 schizophrenia Association study of catechol-O-methyltransferase (COMT) gene Val158Met polymorp... BeFree 20483173 Detail
<0.001 homicidal The purpose of our study is to examine the association between Ala72Ser and Val1... BeFree 18163386 Detail
0.009 depressive disorder In the present study, 256 patients with major depression (DSM-IV) of Caucasian d... BeFree 17522626 Detail
0.345 schizophrenia Executive subprocesses in working memory: relationship to catechol-O-methyltrans... BeFree 12963670 Detail
<0.001 Anemia, Sickle Cell Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorp... BeFree 25102390 Detail
0.345 schizophrenia Catechol-O-methyltransferase Val158Met polymorphism in schizophrenia: associatio... BeFree 16037677 Detail
0.004 Dyskinetic syndrome Catechol-O-methyltransferase Val158Met and the risk of dyskinesias in Parkinson'... BeFree 22083803 Detail
0.004 MAJOR AFFECTIVE DISORDER 6 Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han C... BeFree 9352569 Detail
0.032 Psychotic Disorders The Val158Met polymorphism of the COMT (Catechol-O-Methyltransferase) gene, invo... BeFree 20493536 Detail
<0.001 Aggressive personality A functional single nucleotide polymorphism (V158M) in the COMT gene is associat... BeFree 12842306 Detail
0.032 Psychotic Disorders Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond. BeFree 16476412 Detail
0.021 Malignant neoplasm of prostate A total of 11 htSNPs (including COMT Val(158)Met) were selected based on the res... BeFree 17018638 Detail
0.005 PANIC DISORDER 1 Association between the catechol-O-methyltransferase Val158Met polymorphism and ... BeFree 20457471 Detail
0.345 schizophrenia Associations between COMT Val(158)Met genotype and RTV do not appear to reflect ... BeFree 16815691 Detail
0.005 Depression, Postpartum Among those with history of psychiatric problems, the COMT-Val158Met and 5HTT-LP... BeFree 21099450 Detail
0.345 schizophrenia Catechol-O-methyltransferase Val(158)Met association with parahippocampal physio... BeFree 21144115 Detail
0.005 PANIC DISORDER 1 Influence of the catechol-O-methyltransferase val158met genotype on amygdala and... BeFree 18440204 Detail
0.003 adenocarcinoma In this study, we found that the COMT rs4680 SNP was significantly associated wi... BeFree 22658813 Detail
<0.001 Sciatica We examined if the COMT Val158Met SNP could contribute to discogenic subacute lo... BeFree 22337560 Detail
0.219 schizophrenia A functional interaction between Catechol-O-Methyltransferase (COMT) Val158Met a... BeFree 22128864 Detail
0.178 attention deficit hyperactivity disorder Catechol-O-methyltransferase valine158methionine polymorphism moderates methylph... BeFree 21550019 Detail
0.023 fibromyalgia These results suggest that SNPs rs4680 and rs4818 of the COMT gene may be associ... BeFree 21120493 Detail
<0.001 Psychoses, Drug To investigate the involvement of COMT Val158Met and DAT1 3'-UTR VNTR genotypes ... BeFree 24708432 Detail
0.345 schizophrenia Heterozygosity at catechol-O-methyltransferase Val158Met and schizophrenia: new ... BeFree 20488458 Detail
0.132 Mental disorders The Val158Met polymorphism of the gene encoding catechol-O-methyltransferase (CO... BeFree 18384078 Detail
<0.001 Psychoses, Drug To investigate the involvement of COMT Val158Met and DAT1 3'-UTR VNTR genotypes ... BeFree 24708432 Detail
<0.001 Mild cognitive disorder The aim of this study is to examine the influence of the catechol-O-methyltranfe... BeFree 19793392 Detail
0.181 bipolar disorder This is the first study suggesting that COMT rs4680 modulates FER differently du... BeFree 22222175 Detail
0.012 Nonorganic psychosis COMT Val158Met-stress interaction in psychosis: role of background psychosis ris... BeFree 21073668 Detail
<0.001 carpal tunnel syndrome Catechol-O-methyltransferase Val158Met polymorphism is associated with pain and ... BeFree 24077209 Detail
0.038 Mental Depression The present study investigated the effects of familial risk for depression and t... BeFree 24679392 Detail
<0.001 Acute onset pain Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorp... BeFree 25102390 Detail
0.005 prostate carcinoma The Val158Met polymorphism of the catechol-O-methyltransferase gene is associate... BeFree 16126332 Detail
0.001 conduct disorder Variation in the catechol-O-methyltransferase Val 158 Met polymorphism associate... BeFree 19997043 Detail
0.023 bipolar disorder Functional polymorphisms in the serotonin transporter (5-HTTLPR), catechol-O-met... BeFree 16969276 Detail
0.345 schizophrenia Anhedonia as a phenotype for the Val158Met COMT polymorphism in relatives of pat... BeFree 19025226 Detail
0.017 Anxiety Disorders We show that Val/Val but neither Met/Met nor Val/Met carriers of the catechol-O-... BeFree 25238960 Detail
0.004 MAJOR AFFECTIVE DISORDER 2 Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han C... BeFree 9352569 Detail
0.101 Malignant neoplasm of breast Catechol-O-methyltransferase Val158Met polymorphism and breast cancer risk in As... BeFree 24146281 Detail
0.002 Unipolar Depression Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical o... BeFree 24555772 Detail
<0.001 bulimia nervosa Previous studies have shown that the met allele of the COMT val158met single nuc... BeFree 25216558 Detail
0.012 schizophrenia Effect of catechol O-methyltransferase val(158)met polymorphism on the p50 gatin... BeFree 17448448 Detail
<0.001 Coronary Arteriosclerosis Functional COMT Val158Met polymorphism, risk of acute coronary events and serum ... BeFree 17264883 Detail
0.016 major depressive disorder Effect of the COMT val158met polymorphism on white matter connectivity in patien... BeFree 23618651 Detail
0.058 prostate carcinoma The Val158Met polymorphism of the catechol-O-methyltransferase gene is associate... BeFree 16126332 Detail
0.007 major depressive disorder Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical o... BeFree 24555772 Detail
0.012 Nonorganic psychosis Stress reactivity associated with COMT Val158Met in patients with psychosis may ... BeFree 22128864 Detail
<0.001 Malignant neoplasm of female breast We examined 87 cases and 341 population controls in Taiwan to determine the asso... BeFree 16191465 Detail
0.021 breast carcinoma Catechol-O-methyltransferase Val158Met polymorphism and breast cancer risk in As... BeFree 24146281 Detail
0.004 lingual-facial-buccal dyskinesia Negative association between catechol-O-methyltransferase (COMT) gene Val158Met ... BeFree 15583953 Detail
0.008 Unipolar Depression We investigated the associations between COMT Val(158)Met and depression in a Sw... BeFree 20828831 Detail
<0.001 Mental Depression Changes in severity of depression were assessed with weekly Hamilton Depression ... BeFree 20619611 Detail
0.178 attention deficit hyperactivity disorder No evidence of association between Catechol-O-Methyltransferase (COMT) Val158Met... BeFree 15182372 Detail
<0.001 Breast Cancer, Familial This case control study investigated whether polymorphisms of estrogen metaboliz... BeFree 19863350 Detail
0.058 Malignant neoplasm of prostate The Val158Met polymorphism of the catechol-O-methyltransferase gene is associate... BeFree 16126332 Detail
0.012 Nonorganic psychosis Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior i... BeFree 23799032 Detail
<0.001 Drug usage To investigate the involvement of COMT Val158Met and DAT1 3'-UTR VNTR genotypes ... BeFree 24708432 Detail
0.001 Mixed anxiety and depressive disorder Catechol-O-methyltransferase Val158Met polymorphism influences anxiety, depressi... BeFree 23025981 Detail
0.034 obsessive-compulsive disorder COMT Val158Met polymorphism in schizophrenia with obsessive-compulsive disorder:... BeFree 16043283 Detail
0.178 attention deficit hyperactivity disorder Catechol-O-methyltransferase (COMT; Val158Met) and DA D4-receptor (DRD4; 48 bp V... BeFree 22617852 Detail
0.001 Mixed anxiety and depressive disorder We investigated the associations between COMT Val(158)Met and depression in a Sw... BeFree 20828831 Detail
0.345 schizophrenia Opposite effects of catechol-O-methyltransferase Val158Met on cortical function ... BeFree 19054502 Detail
0.345 schizophrenia Based on the pivotal role ascribed to the prefrontal executive control network f... BeFree 15965969 Detail
0.282 depressive disorder The present study investigated the effects of familial risk for depression and t... BeFree 24679392 Detail
0.345 schizophrenia COMT Val158Met polymorphism in relation to activation and de-activation in the p... BeFree 20398774 Detail
0.155 Mental Depression The present study investigated the effects of familial risk for depression and t... BeFree 24679392 Detail
0.021 breast carcinoma Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatig... BeFree 21898113 Detail
0.017 Anxiety Disorders The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been found to... BeFree 19944409 Detail
0.021 breast carcinoma Association between the COMT Val158Met polymorphism and breast cancer risk: a me... BeFree 22297695 Detail
0.345 schizophrenia Prefrontal dysfunction in schizophrenia controlling for COMT Val158Met genotype ... BeFree 16952445 Detail
0.008 Unipolar Depression Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical o... BeFree 24555772 Detail
0.012 Nonorganic psychosis An experimental study of catechol-o-methyltransferase Val158Met moderation of de... BeFree 16936704 Detail
<0.001 schizophrenia COMT Val(158)Met polymorphism was studied with ARMS-PCR method in 99 outpatients... BeFree 20570494 Detail
0.004 Carcinogenesis Genetic polymorphism Val158Met of catechol-O-methyltransferase (COMT) may contri... BeFree 20591221 Detail
0.178 attention deficit hyperactivity disorder Catechol-O-methyltransferase Val158Met polymorphism is associated with methylphe... BeFree 18214865 Detail
<0.001 bipolar disorder Here, we report the investigation of the differential activity of membrane-bound... BeFree 16984965 Detail
0.178 attention deficit hyperactivity disorder COMT Val158Met variant and functional haplotypes associated with childhood ADHD ... BeFree 21300128 Detail
0.017 Anxiety Disorders We also found a significant interaction effect of COMT met alleles (β = -32.5 SE... BeFree 25722948 Detail
0.038 Mental Depression The Met allele of the Catechol-O-Methyltransferase (COMT) gene functional polymo... BeFree 18828035 Detail
0.181 bipolar disorder The catechol O-methyltransferase Val158Met polymorphism and herpes simplex virus... BeFree 16542182 Detail
0.010 lingual-facial-buccal dyskinesia Evidence from pooled data for genetic association with tardive dyskinesia (TD) s... BeFree 18180754 Detail
0.012 Nonorganic psychosis Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond. BeFree 16476412 Detail
<0.001 spina bifida The COMT rs4680 A allele was negatively related with the risk of spina bifida, w... BeFree 24382678 Detail
<0.001 cocaine dependence Association between the catechol-O-methyltransferase Val158Met polymorphism and ... BeFree 18704099 Detail
0.021 breast carcinoma Val158Met Polymorphism in catechol-O-methyltransferase gene associated with risk... BeFree 14504192 Detail
<0.001 Malignant tumor of colon Therefore, we evaluated the following ten estrogen metabolism-associated single-... BeFree 16202920 Detail
<0.001 Mild cognitive disorder Influence of COMT Val158Met polymorphism on Alzheimer's disease and mild cogniti... BeFree 22890094 Detail
0.021 breast carcinoma COMT Val158Met polymorphism and breast cancer risk: evidence from 26 case-contro... BeFree 20130981 Detail
0.014 Mood Disorders Results indicate a main as well as a GxE effect of the COMT Val158Met variant an... BeFree 22745815 Detail
0.005 PANIC DISORDER 1 Only Val158Met polymorphism of the catechol-O-methyltransferase gene has been im... BeFree 20048750 Detail
0.003 Depression, Postpartum Among those with history of psychiatric problems, the COMT-Val158Met and 5HTT-LP... BeFree 21099450 Detail
0.345 schizophrenia Catechol-O-methyltransferase Val 158 Met polymorphism and antisaccade eye moveme... BeFree 18562342 Detail
0.032 Psychotic Disorders An experimental study of catechol-o-methyltransferase Val158Met moderation of de... BeFree 16936704 Detail
0.101 Malignant neoplasm of breast Influence of catechol-o-methyltransferase genotype (Val158Met) on endocrine, sym... BeFree 21974969 Detail
0.124 22q11 Deletion Syndrome No evidence for an effect of COMT Val158Met genotype on executive function in pa... BeFree 16513880 Detail
0.058 prostate carcinoma The Val158Met polymorphism of the catechol-O-methyltransferase gene is associate... BeFree 16126332 Detail
0.003 Phobic anxiety disorder Functional polymorphisms in the MAO-A uVNTR promoter gene, the COMT gene (Val158... BeFree 15450911 Detail
0.032 Psychotic Disorders Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior i... BeFree 23799032 Detail
0.017 Anxiety Disorders Depression and anxiety in relation to catechol-O-methyltransferase Val158Met gen... BeFree 18578865 Detail
0.017 Anxiety Disorders Given that catechol-O-methyltransferase (COMT) is widely distributed in the hipp... BeFree 25598522 Detail
0.004 Carcinogenesis Val158Met is a common single-nucleotide polymorphism of the COMT gene (Ex4-12 G&... BeFree 17636223 Detail
0.126 Anxiety Disorders The paper focuses on such candidate gene polymorphisms that alter alcoholism-rel... BeFree 17079080 Detail
0.101 Malignant neoplasm of breast When MnSOD Ala was combined with either cytochrome P450 1B1 CYP1B1*1 and catecho... BeFree 15386537 Detail
0.017 Anxiety Disorders A functional polymorphism of the COMT gene, val158met, has been linked to intern... BeFree 23475824 Detail
0.023 fibromyalgia The relationship between a common catechol-O-methyltransferase (COMT) polymorphi... BeFree 20074440 Detail
0.017 Anxiety Disorders This study suggests that the Val158Met COMT polymorphism modulated some psycholo... BeFree 23025981 Detail
0.204 Alcoholic Intoxication, Chronic COMT Val158Met and DRD2 Taq1A may confer their risk of alcohol dependence throug... BeFree 22474103 Detail
<0.001 Malignant neoplasm of female breast We examined 87 cases and 341 population controls in Taiwan to determine the asso... BeFree 16191465 Detail
0.032 Psychotic Disorders Cannabis use and age at onset of psychosis: further evidence of interaction with... BeFree 21231925 Detail
0.021 breast carcinoma A functional Val158Met polymorphism in the COMT gene has been known as a suscept... BeFree 17047485 Detail
0.236 Pain Given that catechol-O-methyltransferase (COMT) is widely distributed in the hipp... BeFree 25598522 Detail
<0.001 Psychotic Disorders Experimental effects of Delta-9-THC on cognition and psychosis are moderated by ... BeFree 16936704 Detail
0.006 Mammographic Density In a cross-sectional study of 396 Caucasian and African-American women, we evalu... BeFree 12052257 Detail
0.003 oppositional defiant disorder COMT Val(158)Met polymorphism has been associated with both symptoms of attentio... BeFree 22270685 Detail
<0.001 desquamative interstitial pneumonia However, neither allele frequencies of COMT Val158Met nor allele frequencies of ... BeFree 24708432 Detail
0.058 Parkinson disease Association of COMT Val158Met polymorphism with wearing-off susceptibility in Pa... BeFree 25367407 Detail
<0.001 Anxiety state A well-characterized single nucleotide polymorphism (472G/A-Val/Met-SNP8) in the... BeFree 11950461 Detail
0.345 schizophrenia The findings provide independent support for the hypothesis that the catechol-O-... BeFree 12372660 Detail
0.101 Malignant neoplasm of breast A functional Val158Met polymorphism in the COMT gene has been known as a suscept... BeFree 17047485 Detail
0.005 PANIC DISORDER 1 Meta-analysis of COMT val158met in panic disorder: ethnic heterogeneity and gend... BeFree 17357147 Detail
0.058 Parkinson disease Val158Met polymorphism of COMT gene and Parkinson's disease risk in Asians. BeFree 25060648 Detail
0.016 major depressive disorder The val158met polymorphism of the COMT gene exemplifies the lack of consensus in... BeFree 20558238 Detail
0.032 Psychotic Disorders A putative interaction between cannabis and variation at rs4680 within the catec... BeFree 21947654 Detail
0.010 Tardive Dyskinesia Evidence from pooled data for genetic association with tardive dyskinesia (TD) s... BeFree 18180754 Detail
<0.001 colon carcinoma Therefore, we evaluated the following ten estrogen metabolism-associated single-... BeFree 16202920 Detail
0.345 schizophrenia Genetic association of catechol-O-methyltransferase val(158)met polymorphism in ... BeFree 24782165 Detail
0.004 Major affective disorder 7 Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han C... BeFree 9352569 Detail
0.003 myocardial infarction The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism,... BeFree 17577421 Detail
0.014 Mood Disorders No association of COMT Val158Met polymorphism with suicidal behavior or CSF mono... BeFree 18828035 Detail
0.005 osteochondritis dissecans The data here are consistent with previous work delineating the different sympto... BeFree 19398820 Detail
0.003 Psychotic symptom The findings suggest that the COMT(Val158Met) polymorphism moderates affective a... BeFree 17525974 Detail
0.345 schizophrenia The C957T polymorphism in the dopamine D2 receptor (DRD2) gene and the Val158Met... BeFree 17113268 Detail
0.040 Mild cognitive disorder The aim of this study is to examine the influence of the catechol-O-methyltranfe... BeFree 19793392 Detail
<0.001 bulimia nervosa COMT Val158Met variant and functional haplotypes associated with childhood ADHD ... BeFree 21300128 Detail
0.181 bipolar disorder The aim of this study is to examine the role of the COMT gene Val158Met polymorp... BeFree 20004480 Detail
0.021 breast carcinoma When MnSOD Ala was combined with either cytochrome P450 1B1 CYP1B1*1 and catecho... BeFree 15386537 Detail
0.101 Malignant neoplasm of breast COMT rs4680 genotypes did not have a modifying effect on the association of gree... BeFree 19074205 Detail
0.058 Parkinson disease Catechol-O-methyltransferase Val158Met polymorphism: modulation of wearing-off s... BeFree 25108642 Detail
0.345 schizophrenia A meta-analysis of the Val158Met COMT polymorphism and violent behavior in schiz... BeFree 22905266 Detail
0.005 PANIC DISORDER 1 The effects of the catechol-O-methyltransferase val158met polymorphism on white ... BeFree 23141115 Detail
0.008 Unipolar Depression The val158met polymorphism of the COMT gene exemplifies the lack of consensus in... BeFree 20558238 Detail
0.002 Tardive Dyskinesia Negative association between catechol-O-methyltransferase (COMT) gene Val158Met ... BeFree 15583953 Detail
0.008 Unipolar Depression COMT val158met influence on electroconvulsive therapy response in major depressi... BeFree 19309019 Detail
0.001 Autism Spectrum Disorders Catechol-O-methyltransferase Val158Met polymorphism and risk of autism spectrum ... BeFree 23613504 Detail
0.236 Pain The Val158Met polymorphism of the COMT gene is associated with increased pain se... BeFree 23210659 Detail
0.345 schizophrenia The COMT Val158Met polymorphism did not appear to significantly affect susceptib... BeFree 15118357 Detail
<0.001 desquamative interstitial pneumonia However, neither allele frequencies of COMT Val158Met nor allele frequencies of ... BeFree 24708432 Detail
0.345 schizophrenia These preliminary results imply that PPI is influenced by COMT Val(158)Met genot... BeFree 18635674 Detail
<0.001 Psychoses, Drug To investigate the involvement of COMT Val158Met and DAT1 3'-UTR VNTR genotypes ... BeFree 24708432 Detail
<0.001 depressive disorder Changes in severity of depression were assessed with weekly Hamilton Depression ... BeFree 20619611 Detail
0.014 Marijuana Abuse The relationship between catechol-O-methyltransferase gene Val158Met (COMT) poly... BeFree 25600541 Detail
0.001 Autism Spectrum Disorders Catechol-O-methyltransferase Val158Met polymorphism and hyperactivity symptoms i... BeFree 23643763 Detail
0.162 panic disorder The effects of the catechol-O-methyltransferase val158met polymorphism on white ... BeFree 23141115 Detail
0.004 Antisocial behavior In this paper, we review the findings regarding four polymorphisms-MAOA (Monoami... BeFree 24764243 Detail
0.032 Psychotic Disorders Stress reactivity associated with COMT Val158Met in patients with psychosis may ... BeFree 22128864 Detail
0.002 Violence Catechol-O-methyltransferase (COMT) val158met polymorphism as a risk factor for ... BeFree 21080103 Detail
0.038 Mental Depression In the present study, 256 patients with major depression (DSM-IV) of Caucasian d... BeFree 17522626 Detail
0.001 Chronic schizophrenia Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizo... BeFree 12372660 Detail
0.178 attention deficit hyperactivity disorder Structural correlates of COMT Val158Met polymorphism in childhood ADHD: a voxel-... BeFree 25495556 Detail
<0.001 Impulsive aggression The catechol o-methyltransferase (COMT) val(158)met polymorphism modulates the a... BeFree 19906087 Detail
0.329 attention deficit hyperactivity disorder Catechol-O-methyltransferase (COMT; Val158Met) and DA D4-receptor (DRD4; 48 bp V... BeFree 22617852 Detail
<0.001 Abnormal involuntary movement We examined 209 Korean schizophrenic patients using the Abnormal Involuntary Mov... BeFree 18424907 Detail
0.023 fibromyalgia Has catechol-O-methyltransferase genotype (Val158Met) an influence on endocrine,... BeFree 24503977 Detail
0.014 Marijuana Abuse We also examined a putative interaction between cannabis and Val(158)Met within ... BeFree 17978319 Detail
0.005 Low Back Pain The COMT rs4680 Met allele contributes to long-lasting low back pain, sciatica a... BeFree 22337560 Detail
0.032 Psychotic Disorders COMT Val158Met-stress interaction in psychosis: role of background psychosis ris... BeFree 21073668 Detail
0.181 bipolar disorder Differential association of the COMT Val158Met polymorphism with clinical phenot... BeFree 18571901 Detail
0.004 MAJOR AFFECTIVE DISORDER 1 Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han C... BeFree 9352569 Detail
0.226 bipolar disorder Functional polymorphisms in the serotonin transporter (5-HTTLPR), catechol-O-met... BeFree 16969276 Detail
0.017 Anxiety Disorders COMT Val(158)Met and 5HTTLPR functional loci interact to predict persistence of ... BeFree 17504250 Detail
0.162 panic disorder Sympathetic nervous function and the effect of the catechol-O-methyltransferase ... BeFree 19900710 Detail
0.345 schizophrenia The role of catechol-O-methyltransferase (COMT) val158met in prefrontal cortical... BeFree 17516763 Detail
0.005 prostate carcinoma No association between COMT Val158Met polymorphism and prostate cancer risk: a m... BeFree 23116175 Detail
0.001 nervous system disorder Genotyping of rs4680 and rs4818 Catechol-O-Methyltransferase gene polymorphisms ... BeFree 25929431 Detail
0.008 heroin dependence The Met allele of the functional COMT Val158Met was associated with protection f... BeFree 25875614 Detail
<0.001 Drug usage To investigate the involvement of COMT Val158Met and DAT1 3'-UTR VNTR genotypes ... BeFree 24708432 Detail
0.345 schizophrenia A common Val-&gt;Met polymorphism (rs4680) in the COMT gene, associated with inc... BeFree 21999147 Detail
0.005 osteochondritis dissecans In subjects of Afrikaner descent, the L/L genotype of the COMT Val158Met polymor... BeFree 16187774 Detail
<0.001 Dysphoric mood The paper focuses on such candidate gene polymorphisms that alter alcoholism-rel... BeFree 17079080 Detail
<0.001 Emotional disorder There have been several reports on the association between the Val(158)Met genet... BeFree 23748501 Detail
0.080 prostate carcinoma The Val158Met polymorphism of the catechol-O-methyltransferase gene is associate... BeFree 16126332 Detail
0.012 Nonorganic psychosis The Val158Met polymorphism of the COMT (Catechol-O-Methyltransferase) gene, invo... BeFree 20493536 Detail
0.021 Malignant neoplasm of prostate Lack of association between COMT Val158Met polymorphism and prostate cancer susc... BeFree 23257985 Detail
0.101 Malignant neoplasm of breast Val158Met Polymorphism in catechol-O-methyltransferase gene associated with risk... BeFree 14504192 Detail
<0.001 Non-small cell lung carcinoma In this study, we found that the COMT rs4680 SNP was significantly associated wi... BeFree 22658813 Detail
<0.001 Chronic Cancer Pain Previous studies have associated the catechol-O-methyltransferase (COMT) enzyme ... BeFree 25185591 Detail
0.016 Antisocial behavior In this paper, we review the findings regarding four polymorphisms-MAOA (Monoami... BeFree 24764243 Detail
0.291 schizophrenia Multifactor-dimensionality reduction analysis suggested a two locus model (rs627... BeFree 19207030 Detail
0.004 fibromyalgia The objective of this study was to determine the potential effects of single nuc... BeFree 18196244 Detail
0.005 Antisocial behavior In this paper, we review the findings regarding four polymorphisms-MAOA (Monoami... BeFree 24764243 Detail
<0.001 ovarian carcinoma Lack of association between the COMT rs4680 polymorphism and ovarian cancer risk... BeFree 25292091 Detail
<0.001 Impulsive aggression Monoamine oxidase A gene promoter (MAOA-uVNTR) and catechol-O-methyltransferase ... BeFree 15457497 Detail
0.032 Psychotic Disorders The COMT gene is probably not a gene for any mental disorder, but the Val158Met ... BeFree 17419009 Detail
<0.001 Pain These exploratory findings suggest that DRD3 Ser9Gly and COMT Val158Met may cont... BeFree 25102390 Detail
0.132 Mental disorders One of its most widely studied variations comprises a common single nucleotide p... BeFree 22138198 Detail
<0.001 Anemia, Sickle Cell Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorp... BeFree 25102390 Detail
0.178 attention deficit hyperactivity disorder Since our previous association studies between attention deficit hyperactivity d... BeFree 19941049 Detail
0.162 panic disorder Asymmetry of prefrontal cortex activities and catechol-O-methyltransferase Val15... BeFree 19429001 Detail
0.005 PANIC DISORDER 1 Gender-specific association between the COMT Val158Met polymorphism and openness... BeFree 24852514 Detail
0.038 Mental Depression The functional Val158Met polymorphism in catechol-O-methyltransferase (COMT) is ... BeFree 20828831 Detail
0.058 prostate carcinoma The Val158Met polymorphism of the catechol-O-methyltransferase gene is associate... BeFree 16126332 Detail
0.006 Hallucinations We sought to determine whether the COMT val158met polymorphism (rs4680) is assoc... BeFree 23069674 Detail
0.013 Malignant neoplasm of lung The COMT rs4680 A allele was positively associated with lung cancer in never smo... BeFree 22331461 Detail
0.017 Anxiety Disorders The interaction of early life experiences with COMT val158met affects anxiety se... BeFree 24118915 Detail
0.004 Migraine Disorders Look beyond Catechol-O-Methyltransferase genotype for cathecolamines derangement... BeFree 25929431 Detail
0.345 schizophrenia A valine/methionine polymorphism of the catechol O-methyltransferase gene at ami... BeFree 16542182 Detail
0.012 Nonorganic psychosis In this study, using an epidemiologically-based sample of 130 patients experienc... BeFree 18407467 Detail
0.005 Antisocial behavior The Val158-allele of the catechol-O-methyltransferase (COMT) Val158Met (rs4680) ... BeFree 25495556 Detail
0.012 Nonorganic psychosis In addition, carriers of the COMT Val(158)Met Val allele were more susceptible t... BeFree 17640440 Detail
0.345 schizophrenia A functional interaction between Catechol-O-Methyltransferase (COMT) Val158Met a... BeFree 22128864 Detail
0.003 Depressive Symptoms Catechol-O-methyltransferase gene val158met polymorphism and depressive symptoms... BeFree 23475824 Detail
0.014 endometrial carcinoma Contribution of catechol-O-methyltransferase Val158Met polymorphism to endometri... BeFree 24390993 Detail
0.345 schizophrenia Negative association between catechol-O-methyltransferase (COMT) gene Val158Met ... BeFree 15583953 Detail
0.003 Psychotic symptom The COMT Val(158)Met genotype may moderate the effect of stress on psychotic sym... BeFree 17640440 Detail
0.016 Tardive Dyskinesia Evidence from pooled data for genetic association with tardive dyskinesia (TD) s... BeFree 18180754 Detail
0.008 Mammographic Density In a cross-sectional study of 396 Caucasian and African-American women, we evalu... BeFree 12052257 Detail
0.001 Drug usage To investigate the involvement of COMT Val158Met and DAT1 3'-UTR VNTR genotypes ... BeFree 24708432 Detail
0.021 breast carcinoma COMT rs4680 genotypes did not have a modifying effect on the association of gree... BeFree 19074205 Detail
0.004 dementia No association of COMT val158met polymorphism and psychotic symptoms in Lewy bod... BeFree 23069674 Detail
<0.001 Nonorganic psychosis Experimental effects of Delta-9-THC on cognition and psychosis are moderated by ... BeFree 16936704 Detail
0.009 depressive disorder The Met allele of the Catechol-O-Methyltransferase (COMT) gene functional polymo... BeFree 18828035 Detail
<0.001 Malignant neoplasm of female breast We examined 135 breast cancer patients and 107 healthy controls in North Syria t... BeFree 22124994 Detail
0.345 schizophrenia COMT Val 158 Met polymorphism is related with interpersonal problem solving in s... BeFree 20570494 Detail
0.003 Psychotic symptom COMT Val(158)Met moderates the effect of stress on psychotic symptoms. BeFree 25068285 Detail
0.016 major depressive disorder Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical o... BeFree 24555772 Detail
0.101 Malignant neoplasm of breast A valine-108-methionine polymorphism in exon 4 of the catechol-O-methyltransfera... BeFree 11142424 Detail
0.262 Malignant neoplasm of prostate The Val158Met polymorphism of the catechol-O-methyltransferase gene is associate... BeFree 16126332 Detail
0.005 prostate carcinoma A total of 11 htSNPs (including COMT Val(158)Met) were selected based on the res... BeFree 17018638 Detail
0.013 Malignant neoplasm of ovary Lack of association between the COMT rs4680 polymorphism and ovarian cancer risk... BeFree 25292091 Detail
0.006 Headache The association between headache and Val158Met polymorphism in the catechol-O-me... BeFree 16688411 Detail
0.058 Parkinson disease Daytime sleepiness and the COMT val158met polymorphism in patients with Parkinso... BeFree 16453988 Detail
0.001 conduct disorder COMT Val(158)Met polymorphism has been associated with both symptoms of attentio... BeFree 22270685 Detail
0.004 MAJOR AFFECTIVE DISORDER 9 Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han C... BeFree 9352569 Detail
<0.001 desquamative interstitial pneumonia However, neither allele frequencies of COMT Val158Met nor allele frequencies of ... BeFree 24708432 Detail
0.132 Mental disorders To examine, in a sample of young psychiatric patients, (n = 157, mean age 17.01 ... BeFree 21231925 Detail
0.132 Mental disorders The catechol O-methyltransferase Val158Met polymorphism and herpes simplex virus... BeFree 16542182 Detail
0.017 Anxiety Disorders The data here are consistent with previous work delineating the different sympto... BeFree 19398820 Detail
0.016 major depressive disorder This work first showed the association of combined Leu136Leu and Val158Met varia... BeFree 25766270 Detail
0.001 Ichthyosis bullosa of Siemens In a regression model, the number of methionine alleles in COMT val158met was li... BeFree 23110189 Detail
0.001 Temporomandibular Joint Dysfunction Syndrome Results show that the COMT rs4680 (val(158)met) polymorphism is most strongly as... BeFree 25218601 Detail
<0.001 Acute onset pain Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorp... BeFree 25102390 Detail
0.005 PANIC DISORDER 1 Asymmetry of prefrontal cortex activities and catechol-O-methyltransferase Val15... BeFree 19429001 Detail
0.236 Pain The val158met polymorphism of human catechol-O-methyltransferase (COMT) affects ... BeFree 20509977 Detail
0.132 Mental disorders A functional polymorphism COMT Val158Met has been associated with psychiatric di... BeFree 24389396 Detail
0.021 breast carcinoma Influence of catechol-o-methyltransferase genotype (Val158Met) on endocrine, sym... BeFree 21974969 Detail
0.016 major depressive disorder COMT val158met influence on electroconvulsive therapy response in major depressi... BeFree 19309019 Detail
0.345 schizophrenia Our findings suggest that the Val158Met polymorphism of the COMT gene might cont... BeFree 16330500 Detail
0.014 Marijuana Abuse The COMT Val158Met genotype seems to modulate the association between cannabis a... BeFree 21231925 Detail
0.017 Anxiety Disorders Association between the COMT Val158Met polymorphism and propensity to anxiety in... BeFree 15900225 Detail
0.032 Psychotic Disorders In this study, using an epidemiologically-based sample of 130 patients experienc... BeFree 18407467 Detail
0.001 Antisocial behavior In this paper, we review the findings regarding four polymorphisms-MAOA (Monoami... BeFree 24764243 Detail
0.002 uterine corpus cancer Contribution of catechol-O-methyltransferase Val158Met polymorphism to endometri... BeFree 24390993 Detail
0.002 Impulsive aggression Monoamine oxidase A gene promoter (MAOA-uVNTR) and catechol-O-methyltransferase ... BeFree 15457497 Detail
0.236 Pain The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain res... BeFree 22132136 Detail
0.005 Impaired cognition Our previous work has implicated two genetic factors in the development of cogni... BeFree 19812213 Detail
0.005 NEUROTICISM These data suggest that involvement of the COMT locus in susceptibility to anxie... BeFree 15956988 Detail
0.021 Malignant neoplasm of prostate No association between COMT Val158Met polymorphism and prostate cancer risk: a m... BeFree 23116175 Detail
0.001 Chronic schizophrenia We analysed the COMT Val158Met polymorphism in 50 patients with chronic schizoph... BeFree 17383818 Detail
0.017 breast carcinoma When MnSOD Ala was combined with either cytochrome P450 1B1 CYP1B1*1 and catecho... BeFree 15386537 Detail
0.101 Malignant neoplasm of breast Association of COMT Val158Met polymorphism and breast cancer risk: an updated me... BeFree 23039364 Detail
0.009 depressive disorder The present results provide further support for a-potentially female-specific-ro... BeFree 22387174 Detail
0.181 bipolar disorder Functional polymorphisms in the serotonin transporter (5-HTTLPR), catechol-O-met... BeFree 16969276 Detail
0.023 fibromyalgia Association between the COMT Val158Met polymorphism and fibromyalgia susceptibil... BeFree 24951880 Detail
0.345 schizophrenia COMT Val158Met polymorphism in schizophrenia with obsessive-compulsive disorder:... BeFree 16043283 Detail
0.093 Hypertensive disease [COMT genotype influences the effect of alcohol on blood pressure: results from ... GAD 19023276 Detail
<0.001 Opiate Addiction Catechol-O-methyltransferase (COMT) gene variants: possible association of the V... BeFree 18270997 Detail
0.004 Migraine Disorders The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism,... BeFree 16688411 Detail
0.014 Marijuana Abuse Observational studies have suggested that psychometric psychosis liability and a... BeFree 16936704 Detail
0.001 Affective Disorders, Psychotic Catechol-O-methyltransferase Val158Met polymorphism and clinical characteristics... BeFree 18092319 Detail
0.012 Nonorganic psychosis Our review examined evidence of an association between the COMT Val(158)Met poly... BeFree 23527885 Detail
0.236 Pain Three common haplotypes of the human COMT gene, divergent in two synonymous and ... BeFree 19365560 Detail
0.345 schizophrenia COMT val(158)met genotype and smooth pursuit eye movements in schizophrenia. BeFree 19647329 Detail
0.001 Manic 64 BD type I patients (39 in manic and 25 in depressive episodes) and 75 healthy... BeFree 22222175 Detail
0.001 TIBIAL MUSCULAR DYSTROPHY, TARDIVE Results show that the COMT rs4680 (val(158)met) polymorphism is most strongly as... BeFree 25218601 Detail
0.345 schizophrenia Increased catechol-O-methyltransferase activity associated with variation in cat... BeFree 15450787 Detail
<0.001 eclampsia The Val158Met polymorphism was more frequent in controls than in PE patients and... BeFree 22886584 Detail
0.215 Alcoholic Intoxication, Chronic The paper focuses on such candidate gene polymorphisms that alter alcoholism-rel... BeFree 17079080 Detail
0.345 schizophrenia The relationship between catechol-O-methyltransferase gene Val158Met (COMT) poly... BeFree 25600541 Detail
0.265 schizophrenia Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical fun... BeFree 19666577 Detail
0.345 schizophrenia Association study of COMT gene Val158Met polymorphism with auditory P300 and per... BeFree 17071544 Detail
0.008 Unipolar Depression Effect of the COMT val158met polymorphism on white matter connectivity in patien... BeFree 23618651 Detail
0.006 Headache Intriguingly, in migraine patients, the COMT rs4680 polymorphism influenced head... BeFree 23773341 Detail
0.032 Psychotic Disorders Because of its role in catecholamine metabolism and several lines of evidence po... BeFree 9352569 Detail
0.001 Cancer pain The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene... BeFree 15927391 Detail
0.005 prostate carcinoma Lack of association between COMT Val158Met polymorphism and prostate cancer susc... BeFree 23257985 Detail
<0.001 Carcinoma of lung The COMT rs4680 A allele was positively associated with lung cancer in never smo... BeFree 22331461 Detail
0.007 major depressive disorder Dopamine 2 receptor gene (DRD2) polymorphism C957T (rs6277) and cathechol-o-meth... BeFree 18929622 Detail
0.004 MAJOR AFFECTIVE DISORDER 4 Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han C... BeFree 9352569 Detail
0.008 Unipolar Depression This work first showed the association of combined Leu136Leu and Val158Met varia... BeFree 25766270 Detail
0.181 bipolar disorder Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han C... BeFree 9352569 Detail
<0.001 Fatigue Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatig... BeFree 21898113 Detail
<0.001 Catch - Finding of sensory dimension of pain N = 83 female participants genotyped for COMT Val158Met received 200 mg sulpirid... BeFree 24773408 Detail
0.003 Kidney Failure, Acute COMT-Val158Met-polymorphism is not a risk factor for acute kidney injury after c... BeFree 24167357 Detail
<0.001 Dysphoric mood The paper focuses on such candidate gene polymorphisms that alter alcoholism-rel... BeFree 17079080 Detail
0.178 attention deficit hyperactivity disorder The functional Val158Met COMT polymorphism appears to affect a host of behaviour... BeFree 19946720 Detail
0.004 Mental disorders Polymorphisms of COMT Val158Met and DAT1 3'-UTR VNTR in illicit drug use and dru... BeFree 24708432 Detail
0.001 Ichthyosis bullosa of Siemens In this study we found an association between the val/val genotype of the val158... BeFree 21437260 Detail
<0.001 Prolapsed lumbar disc The COMT rs4680 Met allele contributes to long-lasting low back pain, sciatica a... BeFree 22337560 Detail
0.101 Malignant neoplasm of breast Association between the COMT Val158Met polymorphism and breast cancer risk: a me... BeFree 22297695 Detail
0.345 schizophrenia Catechol O-methyltransferase Val158Met polymorphism in schizophrenia: differenti... BeFree 14754787 Detail
0.003 Psychotic symptom No association of COMT val158met polymorphism and psychotic symptoms in Lewy bod... BeFree 23069674 Detail
0.012 Nonorganic psychosis Because of its role in catecholamine metabolism and several lines of evidence po... BeFree 9352569 Detail
0.003 Atrial Septal Defects We studied the association of the catechol O-methyltransferase (COMT) Val158Met ... BeFree 20868372 Detail
0.014 Marijuana Abuse Modulation of brain structure by catechol-O-methyltransferase Val(158) Met polym... BeFree 23311613 Detail
0.021 Malignant neoplasm of prostate The Val158Met polymorphism of the catechol-O-methyltransferase gene is associate... BeFree 16126332 Detail
0.345 schizophrenia Influence of catechol-O-methyltransferase Val158Met polymorphism on neuropsychol... BeFree 17383818 Detail
0.001 Drug usage The Met allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism... BeFree 23807274 Detail
0.101 Malignant neoplasm of breast Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatig... BeFree 21898113 Detail
0.012 Nonorganic psychosis Evidence that the COMT(Val158Met) polymorphism moderates sensitivity to stress i... BeFree 17525974 Detail
0.032 Psychotic Disorders Carriers of the COMT Val(158)Met Val allele, but not subjects with the Met/Met g... BeFree 18808401 Detail
0.101 Malignant neoplasm of breast COMT Val158Met polymorphism and breast cancer risk: evidence from 26 case-contro... BeFree 20130981 Detail
0.004 MAJOR AFFECTIVE DISORDER 5 Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han C... BeFree 9352569 Detail
0.001 Affective Disorders, Psychotic Catechol-O-Methyltransferase (COMT) Val158Met variations and cannabis use in fir... BeFree 20493536 Detail
0.012 anorexia nervosa Combined family trio and case-control analysis of the COMT Val158Met polymorphis... BeFree 14681918 Detail
0.001 Atrial Septal Defects The COMT gene Val158Met polymorphism may be a biomarker for phenotypic variation... BeFree 23613504 Detail
0.001 Manic Catechol-O-methyltransferase Val158Met polymorphism affects therapeutic response... BeFree 20004480 Detail
0.178 attention deficit hyperactivity disorder Variation in the catechol-O-methyltransferase Val 158 Met polymorphism associate... BeFree 19997043 Detail
0.032 Psychotic Disorders Evidence that the COMT(Val158Met) polymorphism moderates sensitivity to stress i... BeFree 17525974 Detail
0.162 panic disorder Association between the catechol-O-methyltransferase Val158Met polymorphism and ... BeFree 20457471 Detail
0.038 Mental Depression Our objectives were (1) to examine how baseline stress and change in stress is a... BeFree 22044241 Detail
<0.001 Cognitive changes In the present study, we analyzed the interaction between pharmacological treatm... BeFree 24656901 Detail
0.132 Mental disorders Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior i... BeFree 23799032 Detail
0.236 Pain These exploratory findings suggest that DRD3 Ser9Gly and COMT Val158Met may cont... BeFree 25102390 Detail
0.005 NEUROTICISM COMT Val158Met had an effect on Neuroticism in females by age 25 (p=0.001, Bonfe... BeFree 23928267 Detail
0.345 schizophrenia While it cannot be determined whether TBI influenced the association of COMT Val... BeFree 16387984 Detail
0.008 Unipolar Depression COMT Val158met polymorphism was genotyped in 334 Chinese major depressive disord... BeFree 18533273 Detail
<0.001 Attention deficit-hyperactivity COMT Val158Met polymorphism and socioeconomic status interact to predict attenti... BeFree 19946720 Detail
0.014 Marijuana Abuse A putative interaction between cannabis and variation at rs4680 within the catec... BeFree 21947654 Detail
0.001 Affective Disorders, Psychotic Lack of influence of COMT Val158Met genotype on cognition in first-episode non-a... BeFree 18407467 Detail
0.017 Anxiety Disorders Catechol O-methyltransferase (COMT), the major enzyme determining cortical dopam... BeFree 17146014 Detail
0.127 Substance Withdrawal Syndrome Our results indicate that genotyping for COMT rs4680 and SLC6A4 STin2 VNTR could... BeFree 24684248 Detail
0.002 Chronic pain The meta-analyses showed that fibromyalgia or chronic widespread pain is the onl... BeFree 22722321 Detail
0.016 major depressive disorder COMT Val158met polymorphism was genotyped in 334 Chinese major depressive disord... BeFree 18533273 Detail
0.001 Affective Disorders, Psychotic Catechol-O-methyltransferase Val158Met polymorphism and negative symptoms after ... BeFree 20591499 Detail
0.345 schizophrenia Effects of the val(158)met catechol-O-methyltransferase gene polymorphism on olf... BeFree 22148860 Detail
<0.001 female breast carcinoma We examined 135 breast cancer patients and 107 healthy controls in North Syria t... BeFree 22124994 Detail
0.157 Alcoholic Intoxication, Chronic Sex differences in the influence of COMT Val158Met on alcoholism and smoking in ... BeFree 16499480 Detail
0.345 schizophrenia Differential association of the COMT Val158Met polymorphism with clinical phenot... BeFree 18571901 Detail
0.001 irritable bowel syndrome The relationship between the val158met catechol-O-methyltransferase (COMT) polym... BeFree 21437260 Detail
0.017 Anxiety Disorders Results indicate a main as well as a GxE effect of the COMT Val158Met variant an... BeFree 22745815 Detail
0.003 Substance Withdrawal Syndrome Our results indicate that genotyping for COMT rs4680 and SLC6A4 STin2 VNTR could... BeFree 24684248 Detail
0.132 Mental disorders Polymorphisms of COMT Val158Met and DAT1 3'-UTR VNTR in illicit drug use and dru... BeFree 24708432 Detail
0.017 Anxiety Disorders Functional polymorphisms in the MAO-A uVNTR promoter gene, the COMT gene (Val158... BeFree 15450911 Detail
0.059 Malignant neoplasm of prostate The Val158Met polymorphism of the catechol-O-methyltransferase gene is associate... BeFree 16126332 Detail
0.059 prostate carcinoma The Val158Met polymorphism of the catechol-O-methyltransferase gene is associate... BeFree 16126332 Detail
<0.001 Emotional disorder There have been several reports on the association between the Val(158)Met genet... BeFree 23748501 Detail
<0.001 female breast carcinoma We examined 87 cases and 341 population controls in Taiwan to determine the asso... BeFree 16191465 Detail
0.003 Impaired cognition Their presence may be correlated with cognitive impairment; however, the relatio... BeFree 24551149 Detail
0.009 depressive disorder Our objectives were (1) to examine how baseline stress and change in stress is a... BeFree 22044241 Detail
0.345 schizophrenia Catechol-O-methyltransferase (COMT) val(108/158)met (rs4680) is thought to affec... BeFree 17707347 Detail
0.162 panic disorder Meta-analysis of COMT val158met in panic disorder: ethnic heterogeneity and gend... BeFree 17357147 Detail
0.003 Impaired cognition Our previous work has implicated two genetic factors in the development of cogni... BeFree 19812213 Detail
0.132 Mental disorders Role of the COMT gene Val158Met polymorphism in mental disorders: a review. BeFree 17419009 Detail
0.017 Anxiety Disorders Many of these differences are unconfirmed or minor, but some appear to be of rea... BeFree 17805313 Detail
0.003 multiple sclerosis Catechol-O-methyltransferase Val158Met polymorphism (rs4680) is associated with ... BeFree 24290452 Detail
0.162 panic disorder Influence of the catechol-O-methyltransferase val158met genotype on amygdala and... BeFree 18440204 Detail
0.345 schizophrenia Catechol-o-methyltransferase valine(158)methionine genotype and resting regional... BeFree 19892319 Detail
0.001 Cancer pain It is shown that a polymorphism in the COMT gene, Rs4680 (Val158Met), influence ... BeFree 19094200 Detail
0.097 Malignant neoplasm of breast When MnSOD Ala was combined with either cytochrome P450 1B1 CYP1B1*1 and catecho... BeFree 15386537 Detail
0.003 Impaired cognition The catechol O-methyltransferase Val158Met polymorphism and herpes simplex virus... BeFree 16542182 Detail
0.021 breast carcinoma A valine-108-methionine polymorphism in exon 4 of the catechol-O-methyltransfera... BeFree 11142424 Detail
0.002 Chronic pain This study highlights the importance of COMT rs4680 in influencing the clinical ... BeFree 23773341 Detail
0.038 Mental Depression The present results provide further support for a-potentially female-specific-ro... BeFree 22387174 Detail
<0.001 Sexual abuse The functional polymorphism of the catecholamine-O-methyl-transferase (COMT) gen... BeFree 20002200 Detail
<0.001 Non-small cell lung carcinoma When we corrected for multiple testing using these statistical tools, three nove... BeFree 18258609 Detail
<0.001 Non-small cell lung carcinoma When we corrected for multiple testing using these statistical tools, three nove... BeFree 18258609 Detail
<0.001 Premenopausal breast cancer Although CYP1B1 and COMT genotypes did not exhibit statistically significant ass... BeFree 20037207 Detail
<0.001 Premenopausal breast cancer Although CYP1B1 and COMT genotypes did not exhibit statistically significant ass... BeFree 20037207 Detail
0.329 attention deficit hyperactivity disorder Gene-gene interaction analysis revealed significant additive effect of DBH rs110... BeFree 21216270 Detail
0.178 attention deficit hyperactivity disorder Gene-gene interaction analysis revealed significant additive effect of DBH rs110... BeFree 21216270 Detail
0.114 Malignant neoplasm of breast Pairwise analysis showed that combinations of the ERalpha G allele with the homo... BeFree 18820009 Detail
Annotation

Annotations

DescrptionSourceLinks
NM_000754.4(COMT):c.472G>A (p.Val158Met) AND CATECHOL-O-METHYLTRANSFERASE POLYMORPHISM ClinVar Detail
NM_000754.4(COMT):c.472G>A (p.Val158Met) AND not specified ClinVar Detail
NM_000754.4(COMT):c.472G>A (p.Val158Met) AND Tramadol response ClinVar Detail
NM_000754.4(COMT):c.472G>A (p.Val158Met) AND Schizophrenia ClinVar Detail
Pairwise analysis showed that combinations of the ERalpha G allele with the homozygous Trp genotype ... DisGeNET Detail
Our results demonstrated initial significant associations of two SNPs for DRD2 (rs11608185, genotype... DisGeNET Detail
Pairwise analysis showed that combinations of the ERalpha G allele with the homozygous Trp genotype ... DisGeNET Detail
Pairwise analysis showed that combinations of the ERalpha G allele with the homozygous Trp genotype ... DisGeNET Detail
The Chi-square test, multivariable logistic regression analysis with adjustment for covariates, and ... DisGeNET Detail
The Chi-square test, multivariable logistic regression analysis with adjustment for covariates, and ... DisGeNET Detail
The Chi-square test, multivariable logistic regression analysis with adjustment for covariates, and ... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
Nine gene-candidates, including 5-HTTLPR, MAO-A VNTR, TPH2 rs1386494, 5-HTR1A -1019C-G, 5-HTR2A 102T... DisGeNET Detail
Nine gene-candidates, including 5-HTTLPR, MAO-A VNTR, TPH2 rs1386494, 5-HTR1A -1019C-G, 5-HTR2A 102T... DisGeNET Detail
Nine gene-candidates, including 5-HTTLPR, MAO-A VNTR, TPH2 rs1386494, 5-HTR1A -1019C-G, 5-HTR2A 102T... DisGeNET Detail
Nine gene-candidates, including 5-HTTLPR, MAO-A VNTR, TPH2 rs1386494, 5-HTR1A -1019C-G, 5-HTR2A 102T... DisGeNET Detail
We genotyped a sample of 45 adults with ADHD at four candidate polymorphisms for the disorder (DRD4 ... DisGeNET Detail
We genotyped a sample of 45 adults with ADHD at four candidate polymorphisms for the disorder (DRD4 ... DisGeNET Detail
We genotyped a sample of 45 adults with ADHD at four candidate polymorphisms for the disorder (DRD4 ... DisGeNET Detail
We genotyped a sample of 45 adults with ADHD at four candidate polymorphisms for the disorder (DRD4 ... DisGeNET Detail
Stage 1 analysis included 290 patients with epilepsy and revealed a higher load of adverse psychotro... DisGeNET Detail
Stage 1 analysis included 290 patients with epilepsy and revealed a higher load of adverse psychotro... DisGeNET Detail
We find that P50 and PPI may be influenced by COMT rs4680 polymorphisms in schizophrenia; more excit... DisGeNET Detail
A common functional polymorphism, Val108/158Met (rs4680), and haplotypes rs737865-rs4680-rs165599 in... DisGeNET Detail
We find that P50 and PPI may be influenced by COMT rs4680 polymorphisms in schizophrenia; more excit... DisGeNET Detail
To determine whether COMT is important in substance dependence, rs165774 and rs4680 were genotyped a... DisGeNET Detail
It is possible that the rs165774 SNP, in combination with rs4680, results in a common molecular vari... DisGeNET Detail
The increased volumes in the genu, splenium and total CC in the 22q11DS group were associated with p... DisGeNET Detail
The increased volumes in the genu, splenium and total CC in the 22q11DS group were associated with p... DisGeNET Detail
The increased volumes in the genu, splenium and total CC in the 22q11DS group were associated with p... DisGeNET Detail
The increased volumes in the genu, splenium and total CC in the 22q11DS group were associated with p... DisGeNET Detail
The increased volumes in the genu, splenium and total CC in the 22q11DS group were associated with p... DisGeNET Detail
The increased volumes in the genu, splenium and total CC in the 22q11DS group were associated with p... DisGeNET Detail
Patients with EH (n = 89), EH concurrent with ECa (n = 76), ECa (n = 186), and healthy controls (n =... DisGeNET Detail
Patients with EH (n = 89), EH concurrent with ECa (n = 76), ECa (n = 186), and healthy controls (n =... DisGeNET Detail
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... DisGeNET Detail
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... DisGeNET Detail
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... DisGeNET Detail
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... DisGeNET Detail
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... DisGeNET Detail
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... DisGeNET Detail
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... DisGeNET Detail
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... DisGeNET Detail
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... DisGeNET Detail
Functional alleles that alter alcoholism-related intermediate phenotypes include common alcohol dehy... DisGeNET Detail
Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) polymorphisms were ana... DisGeNET Detail
We explored the influence of interactions between polymorphisms acting upon postsynaptic receptors (... DisGeNET Detail
Age, gender, Fagerström Test for Nicotine Dependence, dopamine pathway genotypes (rs1800497 [ANKK1 E... DisGeNET Detail
We explored the influence of interactions between polymorphisms acting upon postsynaptic receptors (... DisGeNET Detail
We explored the influence of interactions between polymorphisms acting upon postsynaptic receptors (... DisGeNET Detail
We explored the influence of interactions between polymorphisms acting upon postsynaptic receptors (... DisGeNET Detail
Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) polymorphisms were ana... DisGeNET Detail
We explored the influence of interactions between polymorphisms acting upon postsynaptic receptors (... DisGeNET Detail
Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) polymorphisms were ana... DisGeNET Detail
We explored the influence of interactions between polymorphisms acting upon postsynaptic receptors (... DisGeNET Detail
Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) polymorphisms were ana... DisGeNET Detail
We explored the influence of interactions between polymorphisms acting upon postsynaptic receptors (... DisGeNET Detail
We explored the influence of interactions between polymorphisms acting upon postsynaptic receptors (... DisGeNET Detail
Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) polymorphisms were ana... DisGeNET Detail
Val158Met (rs4680, COMT), Taq IA (rs1800497, DRD2) and Ser9Gly (rs6280; DRD3) polymorphisms were ana... DisGeNET Detail
The investigation of the catechol-O-methyltransferase (COMT-[rs4680]) and methylenetetrahydrofolate ... DisGeNET Detail
The investigation of the catechol-O-methyltransferase (COMT-[rs4680]) and methylenetetrahydrofolate ... DisGeNET Detail
The G/G homozygous genotype in COMT rs4680 and A/A homozygous genotype in PLCH1 rs181696 were associ... DisGeNET Detail
The G/G homozygous genotype in COMT rs4680 and A/A homozygous genotype in PLCH1 rs181696 were associ... DisGeNET Detail
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... DisGeNET Detail
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... DisGeNET Detail
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... DisGeNET Detail
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... DisGeNET Detail
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... DisGeNET Detail
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... DisGeNET Detail
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... DisGeNET Detail
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... DisGeNET Detail
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... DisGeNET Detail
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... DisGeNET Detail
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... DisGeNET Detail
However, when this relation was assessed within strata based on estrogen-related factors, a few SNPs... DisGeNET Detail
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... DisGeNET Detail
The genetic polymorphism of rs3087869 (IVS1+2329C&gt;T) (OR 3.200, 95% CI 1.614-6.345) and rs4680 (V... DisGeNET Detail
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... DisGeNET Detail
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... DisGeNET Detail
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... DisGeNET Detail
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... DisGeNET Detail
The genetic polymorphism of rs3087869 (IVS1+2329C&gt;T) (OR 3.200, 95% CI 1.614-6.345) and rs4680 (V... DisGeNET Detail
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... DisGeNET Detail
The genetic polymorphisms of IVS1+2329C&gt;T and Val158Met loci in COMT, Ile462Val and Gly45Asp loci... DisGeNET Detail
The genetic polymorphisms of IVS1+2329C&gt;T and Val158Met loci in COMT, Ile462Val and Gly45Asp loci... DisGeNET Detail
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... DisGeNET Detail
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... DisGeNET Detail
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... DisGeNET Detail
The genetic polymorphism of rs3087869 (IVS1+2329C&gt;T) (OR 3.200, 95% CI 1.614-6.345) and rs4680 (V... DisGeNET Detail
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... DisGeNET Detail
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... DisGeNET Detail
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... DisGeNET Detail
The genetic polymorphisms of IVS1+2329C&gt;T and Val158Met loci in COMT, Ile462Val and Gly45Asp loci... DisGeNET Detail
We assessed catechol-O-methyltransferase (COMT) Val108/158Met (rs4680) and dopamine D2 receptor (DRD... DisGeNET Detail
We assessed catechol-O-methyltransferase (COMT) Val108/158Met (rs4680) and dopamine D2 receptor (DRD... DisGeNET Detail
Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms (SNP) of the CNR1 (r... DisGeNET Detail
Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms (SNP) of the CNR1 (r... DisGeNET Detail
Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms (SNP) of the CNR1 (r... DisGeNET Detail
Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms (SNP) of the CNR1 (r... DisGeNET Detail
Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms (SNP) of the CNR1 (r... DisGeNET Detail
Here, we made a preliminary screening among ten Single Nucleotide Polymorphisms (SNP) of the CNR1 (r... DisGeNET Detail
Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-deriv... DisGeNET Detail
However, genetic effects (COMT Val(158)Met and BDNF Val(66)Met) on experimental pain were moderated ... DisGeNET Detail
Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-deriv... DisGeNET Detail
Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics i... DisGeNET Detail
Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-deriv... DisGeNET Detail
Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics i... DisGeNET Detail
Two common functional polymorphisms in catechol-O-methyltransferase (COMT Val158Met) and brain-deriv... DisGeNET Detail
Patients were also genotyped for three polymorphisms associated with cognitive change in Parkinson's... DisGeNET Detail
Patients were also genotyped for three polymorphisms associated with cognitive change in Parkinson's... DisGeNET Detail
Patients were also genotyped for three polymorphisms associated with cognitive change in Parkinson's... DisGeNET Detail
Results from this study suggest that rs4680 in the COMT gene and rs4646903 in the CYP1A1 gene may be... DisGeNET Detail
Results from this study suggest that rs4680 in the COMT gene and rs4646903 in the CYP1A1 gene may be... DisGeNET Detail
Results from this study suggest that rs4680 in the COMT gene and rs4646903 in the CYP1A1 gene may be... DisGeNET Detail
Results from this study suggest that rs4680 in the COMT gene and rs4646903 in the CYP1A1 gene may be... DisGeNET Detail
Functional polymorphisms in the MAO-A uVNTR promoter gene, the COMT gene (Val158Met) exon 4, and the... DisGeNET Detail
Catechol-O-methyltransferase Val158Met polymorphism influences anxiety, depression, and disability, ... DisGeNET Detail
COMT Val(158) met genotype and striatal D(2/3) receptor binding in adults with 22q11 deletion syndro... DisGeNET Detail
Catechol-O-methyltransferase Val158Met polymorphism moderates anterior cingulate volume in posttraum... DisGeNET Detail
Many of these differences are unconfirmed or minor, but some appear to be of reasonable robustness a... DisGeNET Detail
Only Val158Met polymorphism of the catechol-O-methyltransferase gene has been implicated in suscepti... DisGeNET Detail
The paper focuses on such candidate gene polymorphisms that alter alcoholism-related intermediate ph... DisGeNET Detail
We investigated the associations between COMT Val(158)Met and depression in a Swedish population-bas... DisGeNET Detail
In addition, carriers of the COMT Val(158)Met Val allele were more susceptible to the effect of stre... DisGeNET Detail
Sympathetic nervous function and the effect of the catechol-O-methyltransferase Val(158)Met polymorp... DisGeNET Detail
The associations between the Val158Met in the catechol-O-methyltransferase (COMT) gene and the risk ... DisGeNET Detail
We examined 87 cases and 341 population controls in Taiwan to determine the association between the ... DisGeNET Detail
The functional Val158Met polymorphism in catechol-O-methyltransferase (COMT) is associated with depr... DisGeNET Detail
Reduced dopamine receptor sensitivity as an intermediate phenotype in alcohol dependence and the rol... DisGeNET Detail
We studied the association of the catechol O-methyltransferase (COMT) Val158Met polymorphism and the... DisGeNET Detail
Our review examined evidence of an association between the COMT Val(158)Met polymorphism and both ne... DisGeNET Detail
No association found between 158 Val/Met polymorphism of the COMT gene and schizophrenia with minor ... DisGeNET Detail
Cannabis use profiles and COMT Val158Met genotypes were obtained from 80 inpatients with schizophren... DisGeNET Detail
[The effects of gender and catechol O-methyltransferase (COMT) Val108/158Met polymorphism on emotion... DisGeNET Detail
Our results indicate that genotyping for COMT rs4680 and SLC6A4 STin2 VNTR could be useful for the i... DisGeNET Detail
Evidence from pooled data for genetic association with tardive dyskinesia (TD) showed (1) in COMT(va... DisGeNET Detail
Association of the catechol-O-methyltransferase val158met polymorphism and anxiety-related traits: a... DisGeNET Detail
This work first showed the association of combined Leu136Leu and Val158Met variants of COMT gene wit... DisGeNET Detail
The catechol-O-methyltransferase (COMT) Val158Met polymorphism may be a risk factor for nicotine add... DisGeNET Detail
Clinical symptoms in fibromyalgia are associated to catechol-O-methyltransferase (COMT) gene Val158M... DisGeNET Detail
Catechol-O-methyltransferase Val158Met polymorphism in relation to aggressive schizophrenia in a Kor... DisGeNET Detail
Our results indicate that genotyping for COMT rs4680 and SLC6A4 STin2 VNTR could be useful for the i... DisGeNET Detail
The common methionine (met) for valine (val) at codon 158 (val(158)met) polymorphism in the catechol... DisGeNET Detail
No association between the Catechol-O-Methyltransferase (COMT) val158met polymorphism and cognitive ... DisGeNET Detail
Interaction between catechol-O-methyltransferase (COMT) Val158Met genotype and genetic vulnerability... DisGeNET Detail
In subjects of Afrikaner descent, the L/L genotype of the COMT Val158Met polymorphism was significan... DisGeNET Detail
Both the COMT Val158Met polymorphism and serological evidence of HSV-1 infection affect cognitive fu... DisGeNET Detail
Here, we report the investigation of the differential activity of membrane-bound catechol-O-methyltr... DisGeNET Detail
Dopamine 2 receptor gene (DRD2) polymorphism C957T (rs6277) and cathechol-o-methyltransferase (COMT)... DisGeNET Detail
Carriers of the COMT Val(158)Met Val allele, but not subjects with the Met/Met genotype, showed an i... DisGeNET Detail
Polymorphisms of COMT Val158Met and DAT1 3'-UTR VNTR in illicit drug use and drug-related psychiatri... DisGeNET Detail
Association of COMT Val158Met polymorphism and breast cancer risk: an updated meta-analysis. DisGeNET Detail
Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical function in healthy sub... DisGeNET Detail
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progr... DisGeNET Detail
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progr... DisGeNET Detail
Cannabis use and age at onset of psychosis: further evidence of interaction with COMT Val158Met poly... DisGeNET Detail
The present results provide further support for a-potentially female-specific-role of the COMT val15... DisGeNET Detail
The risk of posttraumatic stress disorder after trauma depends on traumatic load and the catechol-o-... DisGeNET Detail
The aim of the study was to evaluate the influence of COMT Val158Met polymorphism genotype in the ph... DisGeNET Detail
These results do not support the hypothesis that the COMT Val158Met gene polymorphism is associated ... DisGeNET Detail
Gender-specific association between the COMT Val158Met polymorphism and openness to experience in pa... DisGeNET Detail
The catechol o-methyltransferase (COMT) val(158)met polymorphism modulates the association of seriou... DisGeNET Detail
Genetic contribution of catechol-O-methyltransferase polymorphism (Val158Met) in children with chron... DisGeNET Detail
A coding variant in one such gene, encoding the dopamine catabolic enzyme catechol-O-methyltransfera... DisGeNET Detail
[We evaluated the association of COMT genotype at this locus with blood pressure (BP) in 839 alcohol... DisGeNET Detail
Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and ... DisGeNET Detail
The paper focuses on such candidate gene polymorphisms that alter alcoholism-related intermediate ph... DisGeNET Detail
Association of the COMT val158met variant with antidepressant treatment response in major depression... DisGeNET Detail
The impact of the Val158Met catechol-O-methyltransferase genotype on neural correlates of sad facial... DisGeNET Detail
The data here are consistent with previous work delineating the different symptom subtypes of OCD, a... DisGeNET Detail
Contribution of catechol-O-methyltransferase Val158Met polymorphism to endometrial cancer risk in po... DisGeNET Detail
Our study indicates an association between rs4680, an SNP in the COMT gene, and lower risk of apathy... DisGeNET Detail
A putative interaction between cannabis and variation at rs4680 within the catechol-methyl-transfera... DisGeNET Detail
The COMT val(158)met polymorphism was associated with abstinence-related working memory deficits in ... DisGeNET Detail
Compared with nonsmokers, European-American COMT Val158Met double-variant carriers who smoked had in... DisGeNET Detail
Previous studies of a functional variant of the catechol-O-methyl transferase (COMT) gene, Val158Met... DisGeNET Detail
Effect of catechol O-methyltransferase val(158)met polymorphism on the p50 gating endophenotype in s... DisGeNET Detail
Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in irritable bowel syndr... DisGeNET Detail
Association of the COMT val158met variant with antidepressant treatment response in major depression... DisGeNET Detail
Catechol-O-Methyltransferase (COMT) Val158Met variations and cannabis use in first-episode non-affec... DisGeNET Detail
COMT Val158Met modulates the effect of childhood adverse experiences on the risk of alcohol dependen... DisGeNET Detail
This study aimed to derive a comprehensive, whole-brain characterization of large-scale axonal conne... DisGeNET Detail
COMT Val 158 Met polymorphism is associated with cognitive flexibility in a signal discrimination ta... DisGeNET Detail
To better evaluate the role of COMT Val158Met in endometrial carcinogenesis, we performed this meta-... DisGeNET Detail
Moreover, variations in the COMT Val158Met functional polymorphism have been associated with prefron... DisGeNET Detail
Association of the COMT synonymous polymorphism Leu136Leu and missense variant Val158Met with mood d... DisGeNET Detail
Catechol O-methyltransferase val158-met polymorphism is associated with abdominal obesity and blood ... DisGeNET Detail
We sought to determine whether the COMT val158met polymorphism (rs4680) is associated with delusions... DisGeNET Detail
Functional polymorphisms in the MAO-A uVNTR promoter gene, the COMT gene (Val158Met) exon 4, and the... DisGeNET Detail
This study tested the hypothesis that genetic variation in COMT Val158Met and DRD2/ANKK1 Taq1A inter... DisGeNET Detail
Association study of catechol-O-methyltransferase (COMT) gene Val158Met polymorphism with auditory P... DisGeNET Detail
The purpose of our study is to examine the association between Ala72Ser and Val158Met functional pol... DisGeNET Detail
In the present study, 256 patients with major depression (DSM-IV) of Caucasian descent were genotype... DisGeNET Detail
Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met gen... DisGeNET Detail
Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorphisms and acute pain... DisGeNET Detail
Catechol-O-methyltransferase Val158Met polymorphism in schizophrenia: associations with cognitive an... DisGeNET Detail
Catechol-O-methyltransferase Val158Met and the risk of dyskinesias in Parkinson's disease. DisGeNET Detail
Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and ... DisGeNET Detail
The Val158Met polymorphism of the COMT (Catechol-O-Methyltransferase) gene, involved in dopamine reg... DisGeNET Detail
A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive p... DisGeNET Detail
Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond. DisGeNET Detail
A total of 11 htSNPs (including COMT Val(158)Met) were selected based on the resequencing and dense ... DisGeNET Detail
Association between the catechol-O-methyltransferase Val158Met polymorphism and panic disorder: a re... DisGeNET Detail
Associations between COMT Val(158)Met genotype and RTV do not appear to reflect transmission of schi... DisGeNET Detail
Among those with history of psychiatric problems, the COMT-Val158Met and 5HTT-LPR risk variants were... DisGeNET Detail
Catechol-O-methyltransferase Val(158)Met association with parahippocampal physiology during memory e... DisGeNET Detail
Influence of the catechol-O-methyltransferase val158met genotype on amygdala and prefrontal cortex e... DisGeNET Detail
In this study, we found that the COMT rs4680 SNP was significantly associated with a reduced risk of... DisGeNET Detail
We examined if the COMT Val158Met SNP could contribute to discogenic subacute low back pain and scia... DisGeNET Detail
A functional interaction between Catechol-O-Methyltransferase (COMT) Val158Met and methylenetetrahyd... DisGeNET Detail
Catechol-O-methyltransferase valine158methionine polymorphism moderates methylphenidate effects on o... DisGeNET Detail
These results suggest that SNPs rs4680 and rs4818 of the COMT gene may be associated with fibromyalg... DisGeNET Detail
To investigate the involvement of COMT Val158Met and DAT1 3'-UTR VNTR genotypes in the pathogenesis ... DisGeNET Detail
Heterozygosity at catechol-O-methyltransferase Val158Met and schizophrenia: new data and meta-analys... DisGeNET Detail
The Val158Met polymorphism of the gene encoding catechol-O-methyltransferase (COMT) is one of the mo... DisGeNET Detail
To investigate the involvement of COMT Val158Met and DAT1 3'-UTR VNTR genotypes in the pathogenesis ... DisGeNET Detail
The aim of this study is to examine the influence of the catechol-O-methyltranferase (COMT) gene (po... DisGeNET Detail
This is the first study suggesting that COMT rs4680 modulates FER differently during BD episodes and... DisGeNET Detail
COMT Val158Met-stress interaction in psychosis: role of background psychosis risk. DisGeNET Detail
Catechol-O-methyltransferase Val158Met polymorphism is associated with pain and disability, but not ... DisGeNET Detail
The present study investigated the effects of familial risk for depression and the 5-HTTLPR and COMT... DisGeNET Detail
Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorphisms and acute pain... DisGeNET Detail
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progr... DisGeNET Detail
Variation in the catechol-O-methyltransferase Val 158 Met polymorphism associated with conduct disor... DisGeNET Detail
Functional polymorphisms in the serotonin transporter (5-HTTLPR), catechol-O-methyltransferase (Val1... DisGeNET Detail
Anhedonia as a phenotype for the Val158Met COMT polymorphism in relatives of patients with schizophr... DisGeNET Detail
We show that Val/Val but neither Met/Met nor Val/Met carriers of the catechol-O-methyltransferase (C... DisGeNET Detail
Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and ... DisGeNET Detail
Catechol-O-methyltransferase Val158Met polymorphism and breast cancer risk in Asian population. DisGeNET Detail
Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical outcomes in patients ... DisGeNET Detail
Previous studies have shown that the met allele of the COMT val158met single nucleotide polymorphism... DisGeNET Detail
Effect of catechol O-methyltransferase val(158)met polymorphism on the p50 gating endophenotype in s... DisGeNET Detail
Functional COMT Val158Met polymorphism, risk of acute coronary events and serum homocysteine: the Ku... DisGeNET Detail
Effect of the COMT val158met polymorphism on white matter connectivity in patients with major depres... DisGeNET Detail
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progr... DisGeNET Detail
Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical outcomes in patients ... DisGeNET Detail
Stress reactivity associated with COMT Val158Met in patients with psychosis may crucially depend on ... DisGeNET Detail
We examined 87 cases and 341 population controls in Taiwan to determine the association between the ... DisGeNET Detail
Catechol-O-methyltransferase Val158Met polymorphism and breast cancer risk in Asian population. DisGeNET Detail
Negative association between catechol-O-methyltransferase (COMT) gene Val158Met polymorphism and per... DisGeNET Detail
We investigated the associations between COMT Val(158)Met and depression in a Swedish population-bas... DisGeNET Detail
Changes in severity of depression were assessed with weekly Hamilton Depression ratings and analyzed... DisGeNET Detail
No evidence of association between Catechol-O-Methyltransferase (COMT) Val158Met genotype and perfor... DisGeNET Detail
This case control study investigated whether polymorphisms of estrogen metabolizing genes CYP1A1 Msp... DisGeNET Detail
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progr... DisGeNET Detail
Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress... DisGeNET Detail
To investigate the involvement of COMT Val158Met and DAT1 3'-UTR VNTR genotypes in the pathogenesis ... DisGeNET Detail
Catechol-O-methyltransferase Val158Met polymorphism influences anxiety, depression, and disability, ... DisGeNET Detail
COMT Val158Met polymorphism in schizophrenia with obsessive-compulsive disorder: a case-control stud... DisGeNET Detail
Catechol-O-methyltransferase (COMT; Val158Met) and DA D4-receptor (DRD4; 48 bp VNTR) genotypes were ... DisGeNET Detail
We investigated the associations between COMT Val(158)Met and depression in a Swedish population-bas... DisGeNET Detail
Opposite effects of catechol-O-methyltransferase Val158Met on cortical function in healthy subjects ... DisGeNET Detail
Based on the pivotal role ascribed to the prefrontal executive control network for absorbed attentio... DisGeNET Detail
The present study investigated the effects of familial risk for depression and the 5-HTTLPR and COMT... DisGeNET Detail
COMT Val158Met polymorphism in relation to activation and de-activation in the prefrontal cortex: A ... DisGeNET Detail
The present study investigated the effects of familial risk for depression and the 5-HTTLPR and COMT... DisGeNET Detail
Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatigue and pain sensitiv... DisGeNET Detail
The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been found to affect fear extinct... DisGeNET Detail
Association between the COMT Val158Met polymorphism and breast cancer risk: a meta-analysis of 30,19... DisGeNET Detail
Prefrontal dysfunction in schizophrenia controlling for COMT Val158Met genotype and working memory p... DisGeNET Detail
Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical outcomes in patients ... DisGeNET Detail
An experimental study of catechol-o-methyltransferase Val158Met moderation of delta-9-tetrahydrocann... DisGeNET Detail
COMT Val(158)Met polymorphism was studied with ARMS-PCR method in 99 outpatients with schizophrenia. DisGeNET Detail
Genetic polymorphism Val158Met of catechol-O-methyltransferase (COMT) may contribute to estrogen-ind... DisGeNET Detail
Catechol-O-methyltransferase Val158Met polymorphism is associated with methylphenidate response in A... DisGeNET Detail
Here, we report the investigation of the differential activity of membrane-bound catechol-O-methyltr... DisGeNET Detail
COMT Val158Met variant and functional haplotypes associated with childhood ADHD history in women wit... DisGeNET Detail
We also found a significant interaction effect of COMT met alleles (β = -32.5 SE 14.1, P = 0.021). i... DisGeNET Detail
The Met allele of the Catechol-O-Methyltransferase (COMT) gene functional polymorphism (COMT-V158M) ... DisGeNET Detail
The catechol O-methyltransferase Val158Met polymorphism and herpes simplex virus type 1 infection ar... DisGeNET Detail
Evidence from pooled data for genetic association with tardive dyskinesia (TD) showed (1) in COMT(va... DisGeNET Detail
Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond. DisGeNET Detail
The COMT rs4680 A allele was negatively related with the risk of spina bifida, with adjusted OR = 0.... DisGeNET Detail
Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence. DisGeNET Detail
Val158Met Polymorphism in catechol-O-methyltransferase gene associated with risk factors for breast ... DisGeNET Detail
Therefore, we evaluated the following ten estrogen metabolism-associated single-nucleotide polymorph... DisGeNET Detail
Influence of COMT Val158Met polymorphism on Alzheimer's disease and mild cognitive impairment in Ita... DisGeNET Detail
COMT Val158Met polymorphism and breast cancer risk: evidence from 26 case-control studies. DisGeNET Detail
Results indicate a main as well as a GxE effect of the COMT Val158Met variant and childhood maltreat... DisGeNET Detail
Only Val158Met polymorphism of the catechol-O-methyltransferase gene has been implicated in suscepti... DisGeNET Detail
Among those with history of psychiatric problems, the COMT-Val158Met and 5HTT-LPR risk variants were... DisGeNET Detail
Catechol-O-methyltransferase Val 158 Met polymorphism and antisaccade eye movements in schizophrenia... DisGeNET Detail
An experimental study of catechol-o-methyltransferase Val158Met moderation of delta-9-tetrahydrocann... DisGeNET Detail
Influence of catechol-o-methyltransferase genotype (Val158Met) on endocrine, sympathetic nervous and... DisGeNET Detail
No evidence for an effect of COMT Val158Met genotype on executive function in patients with 22q11 de... DisGeNET Detail
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progr... DisGeNET Detail
Functional polymorphisms in the MAO-A uVNTR promoter gene, the COMT gene (Val158Met) exon 4, and the... DisGeNET Detail
Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress... DisGeNET Detail
Depression and anxiety in relation to catechol-O-methyltransferase Val158Met genotype in the general... DisGeNET Detail
Given that catechol-O-methyltransferase (COMT) is widely distributed in the hippocampus and its gene... DisGeNET Detail
Val158Met is a common single-nucleotide polymorphism of the COMT gene (Ex4-12 G&gt;A; rs4680) that r... DisGeNET Detail
The paper focuses on such candidate gene polymorphisms that alter alcoholism-related intermediate ph... DisGeNET Detail
When MnSOD Ala was combined with either cytochrome P450 1B1 CYP1B1*1 and catechol O-methyltransferas... DisGeNET Detail
A functional polymorphism of the COMT gene, val158met, has been linked to internalizing symptoms (i.... DisGeNET Detail
The relationship between a common catechol-O-methyltransferase (COMT) polymorphism val(158) met and ... DisGeNET Detail
This study suggests that the Val158Met COMT polymorphism modulated some psychological variables but ... DisGeNET Detail
COMT Val158Met and DRD2 Taq1A may confer their risk of alcohol dependence through reduced dopamine r... DisGeNET Detail
We examined 87 cases and 341 population controls in Taiwan to determine the association between the ... DisGeNET Detail
Cannabis use and age at onset of psychosis: further evidence of interaction with COMT Val158Met poly... DisGeNET Detail
A functional Val158Met polymorphism in the COMT gene has been known as a susceptible marker for brea... DisGeNET Detail
Given that catechol-O-methyltransferase (COMT) is widely distributed in the hippocampus and its gene... DisGeNET Detail
Experimental effects of Delta-9-THC on cognition and psychosis are moderated by COMT Val(158)Met gen... DisGeNET Detail
In a cross-sectional study of 396 Caucasian and African-American women, we evaluated whether polymor... DisGeNET Detail
COMT Val(158)Met polymorphism has been associated with both symptoms of attention-deficit/hyperactiv... DisGeNET Detail
However, neither allele frequencies of COMT Val158Met nor allele frequencies of DAT1 3'-UTR VNTR wer... DisGeNET Detail
Association of COMT Val158Met polymorphism with wearing-off susceptibility in Parkinson's disease. DisGeNET Detail
A well-characterized single nucleotide polymorphism (472G/A-Val/Met-SNP8) in the coding sequence of ... DisGeNET Detail
The findings provide independent support for the hypothesis that the catechol-O-methyltransferase Va... DisGeNET Detail
A functional Val158Met polymorphism in the COMT gene has been known as a susceptible marker for brea... DisGeNET Detail
Meta-analysis of COMT val158met in panic disorder: ethnic heterogeneity and gender specificity. DisGeNET Detail
Val158Met polymorphism of COMT gene and Parkinson's disease risk in Asians. DisGeNET Detail
The val158met polymorphism of the COMT gene exemplifies the lack of consensus in the literature: alt... DisGeNET Detail
A putative interaction between cannabis and variation at rs4680 within the catechol-methyl-transfera... DisGeNET Detail
Evidence from pooled data for genetic association with tardive dyskinesia (TD) showed (1) in COMT(va... DisGeNET Detail
Therefore, we evaluated the following ten estrogen metabolism-associated single-nucleotide polymorph... DisGeNET Detail
Genetic association of catechol-O-methyltransferase val(158)met polymorphism in Saudi schizophrenia ... DisGeNET Detail
Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and ... DisGeNET Detail
The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met which has... DisGeNET Detail
No association of COMT Val158Met polymorphism with suicidal behavior or CSF monoamine metabolites in... DisGeNET Detail
The data here are consistent with previous work delineating the different symptom subtypes of OCD, a... DisGeNET Detail
The findings suggest that the COMT(Val158Met) polymorphism moderates affective and psychotic respons... DisGeNET Detail
The C957T polymorphism in the dopamine D2 receptor (DRD2) gene and the Val158Met polymorphism in the... DisGeNET Detail
The aim of this study is to examine the influence of the catechol-O-methyltranferase (COMT) gene (po... DisGeNET Detail
COMT Val158Met variant and functional haplotypes associated with childhood ADHD history in women wit... DisGeNET Detail
The aim of this study is to examine the role of the COMT gene Val158Met polymorphism on the clinical... DisGeNET Detail
When MnSOD Ala was combined with either cytochrome P450 1B1 CYP1B1*1 and catechol O-methyltransferas... DisGeNET Detail
COMT rs4680 genotypes did not have a modifying effect on the association of green tea intake with br... DisGeNET Detail
Catechol-O-methyltransferase Val158Met polymorphism: modulation of wearing-off susceptibility in a C... DisGeNET Detail
A meta-analysis of the Val158Met COMT polymorphism and violent behavior in schizophrenia. DisGeNET Detail
The effects of the catechol-O-methyltransferase val158met polymorphism on white matter connectivity ... DisGeNET Detail
The val158met polymorphism of the COMT gene exemplifies the lack of consensus in the literature: alt... DisGeNET Detail
Negative association between catechol-O-methyltransferase (COMT) gene Val158Met polymorphism and per... DisGeNET Detail
COMT val158met influence on electroconvulsive therapy response in major depression. DisGeNET Detail
Catechol-O-methyltransferase Val158Met polymorphism and risk of autism spectrum disorders. DisGeNET Detail
The Val158Met polymorphism of the COMT gene is associated with increased pain sensitivity in morphin... DisGeNET Detail
The COMT Val158Met polymorphism did not appear to significantly affect susceptibility, symptomatolog... DisGeNET Detail
However, neither allele frequencies of COMT Val158Met nor allele frequencies of DAT1 3'-UTR VNTR wer... DisGeNET Detail
These preliminary results imply that PPI is influenced by COMT Val(158)Met genotype in schizophrenia... DisGeNET Detail
To investigate the involvement of COMT Val158Met and DAT1 3'-UTR VNTR genotypes in the pathogenesis ... DisGeNET Detail
Changes in severity of depression were assessed with weekly Hamilton Depression ratings and analyzed... DisGeNET Detail
The relationship between catechol-O-methyltransferase gene Val158Met (COMT) polymorphism and premorb... DisGeNET Detail
Catechol-O-methyltransferase Val158Met polymorphism and hyperactivity symptoms in Egyptian children ... DisGeNET Detail
The effects of the catechol-O-methyltransferase val158met polymorphism on white matter connectivity ... DisGeNET Detail
In this paper, we review the findings regarding four polymorphisms-MAOA (Monoamine oxidase A) uVNTR,... DisGeNET Detail
Stress reactivity associated with COMT Val158Met in patients with psychosis may crucially depend on ... DisGeNET Detail
Catechol-O-methyltransferase (COMT) val158met polymorphism as a risk factor for PTSD after urban vio... DisGeNET Detail
In the present study, 256 patients with major depression (DSM-IV) of Caucasian descent were genotype... DisGeNET Detail
Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia. DisGeNET Detail
Structural correlates of COMT Val158Met polymorphism in childhood ADHD: a voxel-based morphometry st... DisGeNET Detail
The catechol o-methyltransferase (COMT) val(158)met polymorphism modulates the association of seriou... DisGeNET Detail
Catechol-O-methyltransferase (COMT; Val158Met) and DA D4-receptor (DRD4; 48 bp VNTR) genotypes were ... DisGeNET Detail
We examined 209 Korean schizophrenic patients using the Abnormal Involuntary Movement Scale (AIMS), ... DisGeNET Detail
Has catechol-O-methyltransferase genotype (Val158Met) an influence on endocrine, sympathetic nervous... DisGeNET Detail
We also examined a putative interaction between cannabis and Val(158)Met within the catechol-O-methy... DisGeNET Detail
The COMT rs4680 Met allele contributes to long-lasting low back pain, sciatica and disability after ... DisGeNET Detail
COMT Val158Met-stress interaction in psychosis: role of background psychosis risk. DisGeNET Detail
Differential association of the COMT Val158Met polymorphism with clinical phenotypes in schizophreni... DisGeNET Detail
Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and ... DisGeNET Detail
Functional polymorphisms in the serotonin transporter (5-HTTLPR), catechol-O-methyltransferase (Val1... DisGeNET Detail
COMT Val(158)Met and 5HTTLPR functional loci interact to predict persistence of anxiety across adole... DisGeNET Detail
Sympathetic nervous function and the effect of the catechol-O-methyltransferase Val(158)Met polymorp... DisGeNET Detail
The role of catechol-O-methyltransferase (COMT) val158met in prefrontal cortical deficits associated... DisGeNET Detail
No association between COMT Val158Met polymorphism and prostate cancer risk: a meta-analysis. DisGeNET Detail
Genotyping of rs4680 and rs4818 Catechol-O-Methyltransferase gene polymorphisms was performed on 380... DisGeNET Detail
The Met allele of the functional COMT Val158Met was associated with protection from OD. DisGeNET Detail
To investigate the involvement of COMT Val158Met and DAT1 3'-UTR VNTR genotypes in the pathogenesis ... DisGeNET Detail
A common Val-&gt;Met polymorphism (rs4680) in the COMT gene, associated with increased prefrontal do... DisGeNET Detail
In subjects of Afrikaner descent, the L/L genotype of the COMT Val158Met polymorphism was significan... DisGeNET Detail
The paper focuses on such candidate gene polymorphisms that alter alcoholism-related intermediate ph... DisGeNET Detail
There have been several reports on the association between the Val(158)Met genetic polymorphism of t... DisGeNET Detail
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progr... DisGeNET Detail
The Val158Met polymorphism of the COMT (Catechol-O-Methyltransferase) gene, involved in dopamine reg... DisGeNET Detail
Lack of association between COMT Val158Met polymorphism and prostate cancer susceptibility. DisGeNET Detail
Val158Met Polymorphism in catechol-O-methyltransferase gene associated with risk factors for breast ... DisGeNET Detail
In this study, we found that the COMT rs4680 SNP was significantly associated with a reduced risk of... DisGeNET Detail
Previous studies have associated the catechol-O-methyltransferase (COMT) enzyme rs4680 polymorphism ... DisGeNET Detail
In this paper, we review the findings regarding four polymorphisms-MAOA (Monoamine oxidase A) uVNTR,... DisGeNET Detail
Multifactor-dimensionality reduction analysis suggested a two locus model (rs6275/DRD2 and rs4680/CO... DisGeNET Detail
The objective of this study was to determine the potential effects of single nucleotide polymorphism... DisGeNET Detail
In this paper, we review the findings regarding four polymorphisms-MAOA (Monoamine oxidase A) uVNTR,... DisGeNET Detail
Lack of association between the COMT rs4680 polymorphism and ovarian cancer risk: evidence from a me... DisGeNET Detail
Monoamine oxidase A gene promoter (MAOA-uVNTR) and catechol-O-methyltransferase V158M (COMT-V158M) g... DisGeNET Detail
The COMT gene is probably not a gene for any mental disorder, but the Val158Met polymorphism appears... DisGeNET Detail
These exploratory findings suggest that DRD3 Ser9Gly and COMT Val158Met may contribute to pain heter... DisGeNET Detail
One of its most widely studied variations comprises a common single nucleotide polymorphism (SNP), a... DisGeNET Detail
Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorphisms and acute pain... DisGeNET Detail
Since our previous association studies between attention deficit hyperactivity disorder (ADHD) and t... DisGeNET Detail
Asymmetry of prefrontal cortex activities and catechol-O-methyltransferase Val158Met genotype in pat... DisGeNET Detail
Gender-specific association between the COMT Val158Met polymorphism and openness to experience in pa... DisGeNET Detail
The functional Val158Met polymorphism in catechol-O-methyltransferase (COMT) is associated with depr... DisGeNET Detail
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progr... DisGeNET Detail
We sought to determine whether the COMT val158met polymorphism (rs4680) is associated with delusions... DisGeNET Detail
The COMT rs4680 A allele was positively associated with lung cancer in never smokers (for G/A or A/A... DisGeNET Detail
The interaction of early life experiences with COMT val158met affects anxiety sensitivity. DisGeNET Detail
Look beyond Catechol-O-Methyltransferase genotype for cathecolamines derangement in migraine: the Bi... DisGeNET Detail
A valine/methionine polymorphism of the catechol O-methyltransferase gene at amino acid 158 (COMT Va... DisGeNET Detail
In this study, using an epidemiologically-based sample of 130 patients experiencing a first-episode ... DisGeNET Detail
The Val158-allele of the catechol-O-methyltransferase (COMT) Val158Met (rs4680) functional polymorph... DisGeNET Detail
In addition, carriers of the COMT Val(158)Met Val allele were more susceptible to the effect of stre... DisGeNET Detail
A functional interaction between Catechol-O-Methyltransferase (COMT) Val158Met and methylenetetrahyd... DisGeNET Detail
Catechol-O-methyltransferase gene val158met polymorphism and depressive symptoms during early childh... DisGeNET Detail
Contribution of catechol-O-methyltransferase Val158Met polymorphism to endometrial cancer risk in po... DisGeNET Detail
Negative association between catechol-O-methyltransferase (COMT) gene Val158Met polymorphism and per... DisGeNET Detail
The COMT Val(158)Met genotype may moderate the effect of stress on psychotic symptoms. DisGeNET Detail
Evidence from pooled data for genetic association with tardive dyskinesia (TD) showed (1) in COMT(va... DisGeNET Detail
In a cross-sectional study of 396 Caucasian and African-American women, we evaluated whether polymor... DisGeNET Detail
To investigate the involvement of COMT Val158Met and DAT1 3'-UTR VNTR genotypes in the pathogenesis ... DisGeNET Detail
COMT rs4680 genotypes did not have a modifying effect on the association of green tea intake with br... DisGeNET Detail
No association of COMT val158met polymorphism and psychotic symptoms in Lewy body dementias. DisGeNET Detail
Experimental effects of Delta-9-THC on cognition and psychosis are moderated by COMT Val(158)Met gen... DisGeNET Detail
The Met allele of the Catechol-O-Methyltransferase (COMT) gene functional polymorphism (COMT-V158M) ... DisGeNET Detail
We examined 135 breast cancer patients and 107 healthy controls in North Syria to determine the asso... DisGeNET Detail
COMT Val 158 Met polymorphism is related with interpersonal problem solving in schizophrenia. DisGeNET Detail
COMT Val(158)Met moderates the effect of stress on psychotic symptoms. DisGeNET Detail
Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical outcomes in patients ... DisGeNET Detail
A valine-108-methionine polymorphism in exon 4 of the catechol-O-methyltransferase (COMT) gene cause... DisGeNET Detail
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progr... DisGeNET Detail
A total of 11 htSNPs (including COMT Val(158)Met) were selected based on the resequencing and dense ... DisGeNET Detail
Lack of association between the COMT rs4680 polymorphism and ovarian cancer risk: evidence from a me... DisGeNET Detail
The association between headache and Val158Met polymorphism in the catechol-O-methyltransferase gene... DisGeNET Detail
Daytime sleepiness and the COMT val158met polymorphism in patients with Parkinson disease. DisGeNET Detail
COMT Val(158)Met polymorphism has been associated with both symptoms of attention-deficit/hyperactiv... DisGeNET Detail
Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and ... DisGeNET Detail
However, neither allele frequencies of COMT Val158Met nor allele frequencies of DAT1 3'-UTR VNTR wer... DisGeNET Detail
To examine, in a sample of young psychiatric patients, (n = 157, mean age 17.01 years (SD = 3.6)) wh... DisGeNET Detail
The catechol O-methyltransferase Val158Met polymorphism and herpes simplex virus type 1 infection ar... DisGeNET Detail
The data here are consistent with previous work delineating the different symptom subtypes of OCD, a... DisGeNET Detail
This work first showed the association of combined Leu136Leu and Val158Met variants of COMT gene wit... DisGeNET Detail
In a regression model, the number of methionine alleles in COMT val158met was linearly related to pl... DisGeNET Detail
Results show that the COMT rs4680 (val(158)met) polymorphism is most strongly associated with outcom... DisGeNET Detail
Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorphisms and acute pain... DisGeNET Detail
Asymmetry of prefrontal cortex activities and catechol-O-methyltransferase Val158Met genotype in pat... DisGeNET Detail
The val158met polymorphism of human catechol-O-methyltransferase (COMT) affects anterior cingulate c... DisGeNET Detail
A functional polymorphism COMT Val158Met has been associated with psychiatric disorders including su... DisGeNET Detail
Influence of catechol-o-methyltransferase genotype (Val158Met) on endocrine, sympathetic nervous and... DisGeNET Detail
COMT val158met influence on electroconvulsive therapy response in major depression. DisGeNET Detail
Our findings suggest that the Val158Met polymorphism of the COMT gene might contribute to morphologi... DisGeNET Detail
The COMT Val158Met genotype seems to modulate the association between cannabis and age at onset of p... DisGeNET Detail
Association between the COMT Val158Met polymorphism and propensity to anxiety in an Australian popul... DisGeNET Detail
In this study, using an epidemiologically-based sample of 130 patients experiencing a first-episode ... DisGeNET Detail
In this paper, we review the findings regarding four polymorphisms-MAOA (Monoamine oxidase A) uVNTR,... DisGeNET Detail
Contribution of catechol-O-methyltransferase Val158Met polymorphism to endometrial cancer risk in po... DisGeNET Detail
Monoamine oxidase A gene promoter (MAOA-uVNTR) and catechol-O-methyltransferase V158M (COMT-V158M) g... DisGeNET Detail
The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain responses to repeated p... DisGeNET Detail
Our previous work has implicated two genetic factors in the development of cognitive dysfunction in ... DisGeNET Detail
These data suggest that involvement of the COMT locus in susceptibility to anxiety-related traits (i... DisGeNET Detail
No association between COMT Val158Met polymorphism and prostate cancer risk: a meta-analysis. DisGeNET Detail
We analysed the COMT Val158Met polymorphism in 50 patients with chronic schizophrenia randomly alloc... DisGeNET Detail
When MnSOD Ala was combined with either cytochrome P450 1B1 CYP1B1*1 and catechol O-methyltransferas... DisGeNET Detail
Association of COMT Val158Met polymorphism and breast cancer risk: an updated meta-analysis. DisGeNET Detail
The present results provide further support for a-potentially female-specific-role of the COMT val15... DisGeNET Detail
Functional polymorphisms in the serotonin transporter (5-HTTLPR), catechol-O-methyltransferase (Val1... DisGeNET Detail
Association between the COMT Val158Met polymorphism and fibromyalgia susceptibility and fibromyalgia... DisGeNET Detail
COMT Val158Met polymorphism in schizophrenia with obsessive-compulsive disorder: a case-control stud... DisGeNET Detail
[COMT genotype influences the effect of alcohol on blood pressure: results from the COMBINE study.] DisGeNET Detail
Catechol-O-methyltransferase (COMT) gene variants: possible association of the Val158Met variant wit... DisGeNET Detail
The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, that has... DisGeNET Detail
Observational studies have suggested that psychometric psychosis liability and a functional polymorp... DisGeNET Detail
Catechol-O-methyltransferase Val158Met polymorphism and clinical characteristics in first episode no... DisGeNET Detail
Our review examined evidence of an association between the COMT Val(158)Met polymorphism and both ne... DisGeNET Detail
Three common haplotypes of the human COMT gene, divergent in two synonymous and one nonsynonymous (v... DisGeNET Detail
COMT val(158)met genotype and smooth pursuit eye movements in schizophrenia. DisGeNET Detail
64 BD type I patients (39 in manic and 25 in depressive episodes) and 75 healthy controls were genot... DisGeNET Detail
Results show that the COMT rs4680 (val(158)met) polymorphism is most strongly associated with outcom... DisGeNET Detail
Increased catechol-O-methyltransferase activity associated with variation in catechol-O-methyltransf... DisGeNET Detail
The Val158Met polymorphism was more frequent in controls than in PE patients and the placental prese... DisGeNET Detail
The paper focuses on such candidate gene polymorphisms that alter alcoholism-related intermediate ph... DisGeNET Detail
The relationship between catechol-O-methyltransferase gene Val158Met (COMT) polymorphism and premorb... DisGeNET Detail
Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical function in healthy sub... DisGeNET Detail
Association study of COMT gene Val158Met polymorphism with auditory P300 and performance on neurocog... DisGeNET Detail
Effect of the COMT val158met polymorphism on white matter connectivity in patients with major depres... DisGeNET Detail
Intriguingly, in migraine patients, the COMT rs4680 polymorphism influenced headache response to tri... DisGeNET Detail
Because of its role in catecholamine metabolism and several lines of evidence pointing to a locus fo... DisGeNET Detail
The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morph... DisGeNET Detail
Lack of association between COMT Val158Met polymorphism and prostate cancer susceptibility. DisGeNET Detail
The COMT rs4680 A allele was positively associated with lung cancer in never smokers (for G/A or A/A... DisGeNET Detail
Dopamine 2 receptor gene (DRD2) polymorphism C957T (rs6277) and cathechol-o-methyltransferase (COMT)... DisGeNET Detail
Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and ... DisGeNET Detail
This work first showed the association of combined Leu136Leu and Val158Met variants of COMT gene wit... DisGeNET Detail
Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and ... DisGeNET Detail
Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatigue and pain sensitiv... DisGeNET Detail
N = 83 female participants genotyped for COMT Val158Met received 200 mg sulpiride versus placebo and... DisGeNET Detail
COMT-Val158Met-polymorphism is not a risk factor for acute kidney injury after cardiac surgery. DisGeNET Detail
The paper focuses on such candidate gene polymorphisms that alter alcoholism-related intermediate ph... DisGeNET Detail
The functional Val158Met COMT polymorphism appears to affect a host of behaviours mediated by the pr... DisGeNET Detail
Polymorphisms of COMT Val158Met and DAT1 3'-UTR VNTR in illicit drug use and drug-related psychiatri... DisGeNET Detail
In this study we found an association between the val/val genotype of the val158met COMT gene and IB... DisGeNET Detail
The COMT rs4680 Met allele contributes to long-lasting low back pain, sciatica and disability after ... DisGeNET Detail
Association between the COMT Val158Met polymorphism and breast cancer risk: a meta-analysis of 30,19... DisGeNET Detail
Catechol O-methyltransferase Val158Met polymorphism in schizophrenia: differential effects of Val an... DisGeNET Detail
No association of COMT val158met polymorphism and psychotic symptoms in Lewy body dementias. DisGeNET Detail
Because of its role in catecholamine metabolism and several lines of evidence pointing to a locus fo... DisGeNET Detail
We studied the association of the catechol O-methyltransferase (COMT) Val158Met polymorphism and the... DisGeNET Detail
Modulation of brain structure by catechol-O-methyltransferase Val(158) Met polymorphism in chronic c... DisGeNET Detail
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progr... DisGeNET Detail
Influence of catechol-O-methyltransferase Val158Met polymorphism on neuropsychological and functiona... DisGeNET Detail
The Met allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with ... DisGeNET Detail
Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatigue and pain sensitiv... DisGeNET Detail
Evidence that the COMT(Val158Met) polymorphism moderates sensitivity to stress in psychosis: an expe... DisGeNET Detail
Carriers of the COMT Val(158)Met Val allele, but not subjects with the Met/Met genotype, showed an i... DisGeNET Detail
COMT Val158Met polymorphism and breast cancer risk: evidence from 26 case-control studies. DisGeNET Detail
Catechol-O-methyltransferase Val158Met polymorphism: frequency analysis in Han Chinese subjects and ... DisGeNET Detail
Catechol-O-Methyltransferase (COMT) Val158Met variations and cannabis use in first-episode non-affec... DisGeNET Detail
Combined family trio and case-control analysis of the COMT Val158Met polymorphism in European patien... DisGeNET Detail
The COMT gene Val158Met polymorphism may be a biomarker for phenotypic variation in ASD, but these p... DisGeNET Detail
Catechol-O-methyltransferase Val158Met polymorphism affects therapeutic response to mood stabilizer ... DisGeNET Detail
Variation in the catechol-O-methyltransferase Val 158 Met polymorphism associated with conduct disor... DisGeNET Detail
Evidence that the COMT(Val158Met) polymorphism moderates sensitivity to stress in psychosis: an expe... DisGeNET Detail
Association between the catechol-O-methyltransferase Val158Met polymorphism and panic disorder: a re... DisGeNET Detail
Our objectives were (1) to examine how baseline stress and change in stress is associated with cours... DisGeNET Detail
In the present study, we analyzed the interaction between pharmacological treatment (clozapine vs ty... DisGeNET Detail
Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress... DisGeNET Detail
These exploratory findings suggest that DRD3 Ser9Gly and COMT Val158Met may contribute to pain heter... DisGeNET Detail
COMT Val158Met had an effect on Neuroticism in females by age 25 (p=0.001, Bonferroni-corrected for ... DisGeNET Detail
While it cannot be determined whether TBI influenced the association of COMT Val158Met to executive ... DisGeNET Detail
COMT Val158met polymorphism was genotyped in 334 Chinese major depressive disorder (MDD) patients wh... DisGeNET Detail
COMT Val158Met polymorphism and socioeconomic status interact to predict attention deficit/hyperacti... DisGeNET Detail
A putative interaction between cannabis and variation at rs4680 within the catechol-methyl-transfera... DisGeNET Detail
Lack of influence of COMT Val158Met genotype on cognition in first-episode non-affective psychosis. DisGeNET Detail
Catechol O-methyltransferase (COMT), the major enzyme determining cortical dopamine flux, has a comm... DisGeNET Detail
Our results indicate that genotyping for COMT rs4680 and SLC6A4 STin2 VNTR could be useful for the i... DisGeNET Detail
The meta-analyses showed that fibromyalgia or chronic widespread pain is the only type of chronic pa... DisGeNET Detail
COMT Val158met polymorphism was genotyped in 334 Chinese major depressive disorder (MDD) patients wh... DisGeNET Detail
Catechol-O-methyltransferase Val158Met polymorphism and negative symptoms after acute antipsychotic ... DisGeNET Detail
Effects of the val(158)met catechol-O-methyltransferase gene polymorphism on olfactory processing in... DisGeNET Detail
We examined 135 breast cancer patients and 107 healthy controls in North Syria to determine the asso... DisGeNET Detail
Sex differences in the influence of COMT Val158Met on alcoholism and smoking in plains American Indi... DisGeNET Detail
Differential association of the COMT Val158Met polymorphism with clinical phenotypes in schizophreni... DisGeNET Detail
The relationship between the val158met catechol-O-methyltransferase (COMT) polymorphism and irritabl... DisGeNET Detail
Results indicate a main as well as a GxE effect of the COMT Val158Met variant and childhood maltreat... DisGeNET Detail
Our results indicate that genotyping for COMT rs4680 and SLC6A4 STin2 VNTR could be useful for the i... DisGeNET Detail
Polymorphisms of COMT Val158Met and DAT1 3'-UTR VNTR in illicit drug use and drug-related psychiatri... DisGeNET Detail
Functional polymorphisms in the MAO-A uVNTR promoter gene, the COMT gene (Val158Met) exon 4, and the... DisGeNET Detail
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progr... DisGeNET Detail
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progr... DisGeNET Detail
There have been several reports on the association between the Val(158)Met genetic polymorphism of t... DisGeNET Detail
We examined 87 cases and 341 population controls in Taiwan to determine the association between the ... DisGeNET Detail
Their presence may be correlated with cognitive impairment; however, the relationship between region... DisGeNET Detail
Our objectives were (1) to examine how baseline stress and change in stress is associated with cours... DisGeNET Detail
Catechol-O-methyltransferase (COMT) val(108/158)met (rs4680) is thought to affect dopamine regulated... DisGeNET Detail
Meta-analysis of COMT val158met in panic disorder: ethnic heterogeneity and gender specificity. DisGeNET Detail
Our previous work has implicated two genetic factors in the development of cognitive dysfunction in ... DisGeNET Detail
Role of the COMT gene Val158Met polymorphism in mental disorders: a review. DisGeNET Detail
Many of these differences are unconfirmed or minor, but some appear to be of reasonable robustness a... DisGeNET Detail
Catechol-O-methyltransferase Val158Met polymorphism (rs4680) is associated with pain in multiple scl... DisGeNET Detail
Influence of the catechol-O-methyltransferase val158met genotype on amygdala and prefrontal cortex e... DisGeNET Detail
Catechol-o-methyltransferase valine(158)methionine genotype and resting regional cerebral blood flow... DisGeNET Detail
It is shown that a polymorphism in the COMT gene, Rs4680 (Val158Met), influence pain sensitivity in ... DisGeNET Detail
When MnSOD Ala was combined with either cytochrome P450 1B1 CYP1B1*1 and catechol O-methyltransferas... DisGeNET Detail
The catechol O-methyltransferase Val158Met polymorphism and herpes simplex virus type 1 infection ar... DisGeNET Detail
A valine-108-methionine polymorphism in exon 4 of the catechol-O-methyltransferase (COMT) gene cause... DisGeNET Detail
This study highlights the importance of COMT rs4680 in influencing the clinical response to drugs us... DisGeNET Detail
The present results provide further support for a-potentially female-specific-role of the COMT val15... DisGeNET Detail
The functional polymorphism of the catecholamine-O-methyl-transferase (COMT) gene Val158Met signific... DisGeNET Detail
When we corrected for multiple testing using these statistical tools, three novel associations of NS... DisGeNET Detail
When we corrected for multiple testing using these statistical tools, three novel associations of NS... DisGeNET Detail
Although CYP1B1 and COMT genotypes did not exhibit statistically significant association with breast... DisGeNET Detail
Although CYP1B1 and COMT genotypes did not exhibit statistically significant association with breast... DisGeNET Detail
Gene-gene interaction analysis revealed significant additive effect of DBH rs1108580 and DRD4 rs1800... DisGeNET Detail
Gene-gene interaction analysis revealed significant additive effect of DBH rs1108580 and DRD4 rs1800... DisGeNET Detail
Pairwise analysis showed that combinations of the ERalpha G allele with the homozygous Trp genotype ... DisGeNET Detail

Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs4680 dbSNP
Genome
hg19
Position
chr22:19,951,271-19,951,271
Variant Type
snv
Reference Allele
G
Alternative Allele
A
Filtering Status (HGVD)
PASS
# of samples (HGVD)
1202
Mean of sample read depth (HGVD)
55.85
Standard deviation of sample read depth (HGVD)
27.78
Number of reference allele (HGVD)
1659
Number of alternative allele (HGVD)
745
Allele Frequency (HGVD)
0.3099001663893511
Gene Symbol (HGVD)
COMT
ToMMo VCF FILTER column value (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
PASS
Total VCF ID column value (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
rs4680
Allele frequency, for each ALT allele (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
0.3173
Allele count in genotypes, for each ALT allele (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
5318
Total number of alleles in called genotypes (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
16760
East Asian Chromosome Counts (ExAC)
8314
East Asian Allele Counts (ExAC)
2369
East Asian Heterozygous Counts (ExAC)
1715
East Asian Homozygous Counts (ExAC)
327
East Asian Allele Frequency (ExAC)
0.2849410632667789
Chromosome Counts in All Race (ExAC)
117012
Allele Counts in All Race (ExAC)
55317
Heterozygous Counts in All Race (ExAC)
28887
Homozygous Counts in All Race (ExAC)
13215
Allele Frequency in All Race (ExAC)
0.4727463849861553
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