Annotation Detail
Information
- Associated Genes
- TPH1
- Associated Variants
-
TPH1 MUTATION
TPH1 MUTATION
P2RX7 p.His34= (p.H34=) ( ENST00000328963.10 )
P2RX7 p.Gln460Arg (p.Q460R) ( ENST00000328963.10 )
HTR2A p.Val241Leu (p.V241L) ( ENST00000543956.5, ENST00000542664.4 )
HTR2A p.Val241Met (p.V241M) ( ENST00000542664.4, ENST00000543956.5 )
HTR2A p.Ser34= (p.S34=) ( ENST00000542664.4, ENST00000543956.5 )
CRHR1 c.122-1309A>C, LINC02210-CRHR1 c.-404-1309A>C ( ENST00000314537.10, ENST00000577353.5, ENST00000580876.6, ENST00000398285.7, ENST00000634540.1, ENST00000352855.9 )
COMT p.Val158Met (p.V158M) ( ENST00000361682.11, ENST00000403184.5, ENST00000403710.5, ENST00000406520.7, ENST00000407537.5, ENST00000428707.2, ENST00000449653.5, ENST00000676678.1, ENST00000678255.1, ENST00000678769.1, ENST00000678868.1 )
FKBP5 c.106-2636A>G ( ENST00000357266.9, ENST00000536438.5, ENST00000539068.5, ENST00000542713.1 )
P2RX7 p.His34= (p.H34=) ( ENST00000328963.10 )
P2RX7 p.Gln460Arg (p.Q460R) ( ENST00000328963.10 )
HTR2A p.Val241Leu (p.V241L) ( ENST00000542664.4, ENST00000543956.5 )
HTR2A p.Val241Met (p.V241M) ( ENST00000542664.4, ENST00000543956.5 )
HTR2A p.Ser34= (p.S34=) ( ENST00000542664.4, ENST00000543956.5 )
CRHR1 c.122-1309A>C, LINC02210-CRHR1 c.-404-1309A>C ( ENST00000314537.10, ENST00000352855.9, ENST00000398285.7, ENST00000577353.5, ENST00000580876.6, ENST00000634540.1 )
COMT p.Val158Met (p.V158M) ( ENST00000361682.11, ENST00000403184.5, ENST00000403710.5, ENST00000406520.7, ENST00000407537.5, ENST00000428707.2, ENST00000449653.5, ENST00000676678.1, ENST00000678255.1, ENST00000678769.1, ENST00000678868.1 )
FKBP5 c.106-2636A>G ( ENST00000357266.9, ENST00000536438.5, ENST00000539068.5, ENST00000542713.1 ) - Associated Disease
- Mental Depression
- Source Database
- DisGeNET
- Description
- To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
- Pubmed
- 23157339
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.026113296634743
- Year of publication
- 2013
Drugs