chr6:35639794:T>C Detail (hg38) (FKBP5)

Information

Genome

Assembly Position
hg19 chr6:35,607,571-35,607,571 View the variant detail on this assembly version.
hg38 chr6:35,639,794-35,639,794

HGVS

Type Transcript Protein
RefSeq NM_004117.3:c.106-2636A>G
NM_001145775.2:c.106-2636A>G
NM_001145776.1:c.106-2636A>G
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

JP HGVD:[No Data.]
ToMMo:0.773
NCBN:[No Data.]
NCBN(Hondo):[No Data.]
NCBN(Ryukyu):[No Data.]
East asia ExAC:[No Data.]

Prediction

ClinVar

Clinical Significance Likely risk allele
Review star
Show details
Links
Type Database ID Link
Gene MIM 602623 OMIM
HGNC 3721 HGNC
Ensembl ENSG00000096060 Ensembl
NCBI NCBI
Gene Cards Gene Cards
OncoKB OncoKB
Type Database ID Link
Variant TogoVar tgv24952240 TogoVar
COSMIC
MONDO
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
Clinical significance Last evaluated Review status Condition Origin Links
Likely risk allele no assertion criteria provided post-traumatic stress disorder germline Detail
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.001 child abuse behavior FKBP5 (rs1360780) and CRHR1 (rs12944712) polymorphisms significantly interacted ... BeFree 24099078 Detail
0.001 child abuse behavior FKBP5 (rs1360780) and CRHR1 (rs12944712) polymorphisms significantly interacted ... BeFree 24099078 Detail
0.127 major depressive disorder To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.082 depressive disorder To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.018 Mental Depression The FKBP5 rs1360780 polymorphism is associated with plasma cortisol and FKBP5 mR... BeFree 25522420 Detail
0.085 post-traumatic stress disorder As FKBP5 single-nucleotide polymorphism rs1360780 has a putative functional role... BeFree 24959896 Detail
0.026 Mental Depression To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.002 Unipolar Depression To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.013 Mental Depression To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.006 depressive disorder To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.088 depressive disorder To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.018 Mental Depression This study revealed interactions between physical abuse and rs1360780 of the FKB... BeFree 21654733 Detail
0.126 major depressive disorder In the present study, we investigated whether the FKBP5 polymorphism rs1360780 a... BeFree 25522420 Detail
0.018 Mental Depression To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
<0.001 heroin dependence Fourteen SNPs showed nominally significant association with heroin addiction (p ... BeFree 24766650 Detail
0.087 depressive disorder To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.002 depressive disorder To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.208 depressive disorder Polymorphisms in the FK506 binding protein 5 (FKBP5) gene have been shown to inf... BeFree 25522420 Detail
0.004 Unipolar Depression In the present study, we investigated whether the FKBP5 polymorphism rs1360780 a... BeFree 25522420 Detail
<0.001 Stress, Psychological The purpose of this study was to examine whether FKBP5 rs1360780 moderates relat... BeFree 25462914 Detail
0.003 major depressive disorder To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.020 Mental Depression Polymorphisms in the FK506 binding protein 5 (FKBP5) gene have been shown to inf... BeFree 25522420 Detail
0.004 Unipolar Depression To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.020 Mental Depression To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.005 Mental disorders The common single nucleotide polymorphism (SNP) rs1360780 (C/T) of the FK506 Bin... BeFree 25331639 Detail
<0.001 Stress, Psychological It has been reported that a C/T single nucleotide polymorphism in the intron 2 o... BeFree 20849924 Detail
0.007 post-traumatic stress disorder The common single nucleotide polymorphism (SNP) rs1360780 (C/T) of the FK506 Bin... BeFree 25331639 Detail
0.005 Mental disorders The FKBP5 gene single nucleotide polymorphisms (SNP), rs1360780, has been found ... BeFree 22825419 Detail
0.006 depressive disorder This study revealed interactions between physical abuse and rs1360780 of the FKB... BeFree 21654733 Detail
0.009 depressive disorder To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.033 Mental Depression To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.006 depressive disorder To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.038 Mental Depression To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.009 Mental Depression To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.043 Mental Depression To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.007 depressive disorder To investigate the possible relationship between genetic risk factors and depres... BeFree 23157339 Detail
0.006 depressive disorder The FKBP5 rs1360780 polymorphism is associated with plasma cortisol and FKBP5 mR... BeFree 25522420 Detail
0.003 major depressive disorder The single nucleotide polymorphisms FKBP5:rs1360780, BDNF:rs6265 (Val66Met), P2R... BeFree 20226536 Detail
0.003 Unipolar Depression The single nucleotide polymorphisms FKBP5:rs1360780, BDNF:rs6265 (Val66Met), P2R... BeFree 20226536 Detail
Annotation

Annotations

DescrptionSourceLinks
NM_004117.4(FKBP5):c.106-2636A>G AND Post-traumatic stress disorder ClinVar Detail
FKBP5 (rs1360780) and CRHR1 (rs12944712) polymorphisms significantly interacted with child abuse and... DisGeNET Detail
FKBP5 (rs1360780) and CRHR1 (rs12944712) polymorphisms significantly interacted with child abuse and... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
The FKBP5 rs1360780 polymorphism is associated with plasma cortisol and FKBP5 mRNA expression after ... DisGeNET Detail
As FKBP5 single-nucleotide polymorphism rs1360780 has a putative functional role in the regulation o... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
This study revealed interactions between physical abuse and rs1360780 of the FKBP5 gene, confirming ... DisGeNET Detail
In the present study, we investigated whether the FKBP5 polymorphism rs1360780 and lifetime history ... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
Fourteen SNPs showed nominally significant association with heroin addiction (p &lt; 0.05), includin... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
Polymorphisms in the FK506 binding protein 5 (FKBP5) gene have been shown to influence glucocorticoi... DisGeNET Detail
In the present study, we investigated whether the FKBP5 polymorphism rs1360780 and lifetime history ... DisGeNET Detail
The purpose of this study was to examine whether FKBP5 rs1360780 moderates relations between differe... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
Polymorphisms in the FK506 binding protein 5 (FKBP5) gene have been shown to influence glucocorticoi... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
The common single nucleotide polymorphism (SNP) rs1360780 (C/T) of the FK506 Binding Protein 5 (FKBP... DisGeNET Detail
It has been reported that a C/T single nucleotide polymorphism in the intron 2 of FKBP5 gene (rs1360... DisGeNET Detail
The common single nucleotide polymorphism (SNP) rs1360780 (C/T) of the FK506 Binding Protein 5 (FKBP... DisGeNET Detail
The FKBP5 gene single nucleotide polymorphisms (SNP), rs1360780, has been found to modulate GC sensi... DisGeNET Detail
This study revealed interactions between physical abuse and rs1360780 of the FKBP5 gene, confirming ... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
To investigate the possible relationship between genetic risk factors and depression in AD, we asses... DisGeNET Detail
The FKBP5 rs1360780 polymorphism is associated with plasma cortisol and FKBP5 mRNA expression after ... DisGeNET Detail
The single nucleotide polymorphisms FKBP5:rs1360780, BDNF:rs6265 (Val66Met), P2RX7:2230912 (Gln460Ar... DisGeNET Detail
The single nucleotide polymorphisms FKBP5:rs1360780, BDNF:rs6265 (Val66Met), P2RX7:2230912 (Gln460Ar... DisGeNET Detail

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
Genome
hg38
Position
chr6:35,639,794-35,639,794
Variant Type
snv
Reference Allele
T
Alternative Allele
C
ToMMo VCF FILTER column value (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
PASS
Total VCF ID column value (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
rs1360780
Allele frequency, for each ALT allele (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
0.7728
Allele count in genotypes, for each ALT allele (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
12952
Total number of alleles in called genotypes (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
16760
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