chr10:112950247:> Detail (hg38)

Information

Genome

Assembly Position
hg19 chr10:114,710,006-114,927,437 
hg38 chr10:112,950,247-113,167,678

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
<0.001 Developmental Disabilities NA BeFree Detail
<0.001 Clubbed Fingers NA BeFree Detail
<0.001 ulcerative colitis NA BeFree Detail
0.133 Colonic Neoplasms NA BeFree,CTD_human,GAD,LHGDN Detail
0.001 Coronary Arteriosclerosis NA BeFree Detail
0.009 Coronary heart disease NA BeFree,GAD,LHGDN Detail
0.006 Crohn Disease NA BeFree,GAD,LHGDN Detail
0.004 Diabetes Mellitus, Insulin-Dependent Interestingly, genetic signals from both T1D and T2D are also seen in LADA, incl... BeFree,GAD 25189437 Detail
0.005 Diabetic Angiopathies NA GAD,LHGDN Detail
0.001 Diabetic Nephropathy NA BeFree Detail
<0.001 diabetic retinopathy Transcription factor 7-like 2 polymorphisms and diabetic retinopathy: a systemat... BeFree 25117344 Detail
<0.001 diabetic retinopathy The gene polymorphisms of UCP1 but not PPAR γ and TCF7L2 are associated with dia... BeFree 25274455 Detail
<0.001 Endocrine System Diseases NA BeFree Detail
0.003 Endometrial Neoplasms NA LHGDN Detail
<0.001 External exotoses Immunohistochemical analyses revealed that TCF7L2 is differentially expressed an... BeFree 25498973 Detail
0.007 Fatty Liver NA GAD,LHGDN Detail
0.002 Fetal Diseases NA GAD Detail
0.005 Fuchs Endothelial Dystrophy Association of common variants in TCF4 and PTPRG with Fuchs' corneal dystrophy: ... BeFree 25299301 Detail
0.005 Fuchs Endothelial Dystrophy Among the several genes and loci associated with FECD, the strongest association... BeFree 25593321 Detail
0.005 Fuchs Endothelial Dystrophy TCF4 Triplet Repeat Expansion and Nuclear RNA Foci in Fuchs' Endothelial Corneal... BeFree 25722209 Detail
0.005 Fuchs Endothelial Dystrophy Association of TCF4 polymorphisms and Fuchs' endothelial dystrophy: a meta-analy... BeFree 26087656 Detail
0.005 Fuchs Endothelial Dystrophy Expansion of CTG18.1 Trinucleotide Repeat in TCF4 Is a Potent Driver of Fuchs' C... BeFree 26200491 Detail
0.005 Fuchs Endothelial Dystrophy Trinucleotide Repeat Expansion in the TCF4 Gene in Fuchs' Endothelial Corneal Dy... BeFree 26218914 Detail
<0.001 Gastrointestinal Neoplasms NA BeFree Detail
<0.001 glioblastoma NA BeFree Detail
<0.001 Glioma NA BeFree Detail
<0.001 Hepatitis, Alcoholic These TFs are AR, EGR1, MYC, TCF4, ATF3, JUN, FOXO3, STAT1, HIF1A and EOMES, whe... BeFree 26166650 Detail
<0.001 Herpes Simplex Infections NA BeFree Detail
<0.001 Hirschsprung Disease NA BeFree Detail
0.003 HIV Infections NA BeFree,GAD Detail
0.012 hyperglycemia Linagliptin significantly improved hyperglycaemia in patients with type 2 diabet... BeFree,GAD,LHGDN 24906949 Detail
<0.001 hyperinsulinism NA BeFree Detail
0.002 Hyperlipidemia NA GAD Detail
<0.001 Hyperlipidemia, Familial Combined NA BeFree Detail
0.120 Hyperplasia NA CTD_human Detail
0.007 Hypertensive disease NA BeFree,GAD Detail
<0.001 Ileal Diseases NA BeFree Detail
<0.001 Inflammatory Bowel Diseases NA BeFree Detail
0.024 Insulin resistance NA GAD Detail
<0.001 Intestinal Neoplasms NA BeFree Detail
<0.001 Intestinal Polyps NA BeFree Detail
0.003 Kidney Diseases NA BeFree,GAD Detail
0.003 leukemia NA BeFree,LHGDN Detail
<0.001 Acute lymphocytic leukemia NA BeFree Detail
0.003 Liver diseases NA BeFree,LHGDN Detail
0.005 Lung Neoplasms NA LHGDN Detail
<0.001 Lymphohistiocytosis, Hemophagocytic NA BeFree Detail
0.001 Malignant neoplasm of stomach Moreover, the expression of WISP3 was positively correlated with the expression ... BeFree 25400723 Detail
<0.001 melanoma NA BeFree Detail
0.001 Mental Retardation NA BeFree Detail
0.002 Neoplasm Metastasis IKKβ Enforces a LIN28B/TCF7L2 Positive Feedback Loop That Promotes Cancer Cell S... BeFree 25744721 Detail
0.030 obesity Thus, we evaluated the association of 17 single-nucleotide polymorphisms (SNPs) ... BeFree,GAD 25224558 Detail
<0.001 Degenerative polyarthritis NA BeFree Detail
<0.001 Cartilaginous exostosis Immunohistochemical analyses revealed that TCF7L2 is differentially expressed an... BeFree 25498973 Detail
<0.001 ovarian carcinoma NA BeFree Detail
0.003 Ovarian Diseases NA BeFree Detail
<0.001 Peripheral neuropathy NA BeFree Detail
0.010 polycystic ovary syndrome NA BeFree,GAD,LHGDN Detail
0.002 Adenomatous Polyposis Coli NA BeFree Detail
0.002 Postoperative Complications NA GAD Detail
0.002 Pregnancy Complications NA GAD Detail
0.002 Pregnancy in Diabetics NA GAD Detail
0.008 Prostatic Neoplasms NA GAD,LHGDN Detail
<0.001 Psychotic Disorders NA BeFree Detail
0.002 Precocious Puberty NA GAD Detail
0.003 Rectal Neoplasms NA LHGDN Detail
<0.001 schizoaffective disorder NA BeFree Detail
<0.001 Seizures NA BeFree Detail
0.001 Severe mental retardation (I.Q. 20-34) NA BeFree Detail
0.002 Starvation NA GAD Detail
0.004 Stomach Neoplasms NA BeFree,LHGDN Detail
<0.001 Cerebrovascular accident NA BeFree Detail
0.002 Thinness NA GAD Detail
0.002 Tobacco use disorder NA GAD Detail
<0.001 Encephalopathies NA BeFree Detail
<0.001 Adenocarcinoma of lung (disorder) NA BeFree Detail
<0.001 proliferative diabetic retinopathy NA BeFree Detail
<0.001 adrenoleukodystrophy NA BeFree Detail
0.002 Malnutrition NA GAD Detail
<0.001 Angelman syndrome NA BeFree Detail
<0.001 Tumor Progression NA BeFree Detail
<0.001 Diabetes, Autoimmune NA BeFree Detail
<0.001 congenital diaphragmatic hernia NA BeFree Detail
0.001 Malignant neoplasm of lung NA BeFree Detail
0.002 age related macular degeneration NA GAD Detail
<0.001 autonomic neuropathy NA BeFree Detail
0.005 Impaired glucose tolerance Interestingly, the persistent overexpression of Tcf7l2 in non-pancreatic tissues... BeFree,GAD 25398947 Detail
<0.001 Liver and Intrahepatic Biliary Tract Carcinoma NA BeFree Detail
<0.001 Conventional (Clear Cell) Renal Cell Carcinoma NA BeFree Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent KCNJ11 Lys23Glu and TCF7L2 rs290487(C/T) polymorphisms affect therapeutic effica... BeFree 20054294 Detail
<0.001 Malignant neoplasm of liver NA BeFree Detail
<0.001 Breast Cancer, Familial NA BeFree Detail
<0.001 Multiple malignancy NA BeFree Detail
<0.001 intestinal cancer A polymorphic enhancer near GREM1 influences bowel cancer risk through different... BeFree 25131200 Detail
<0.001 Nonorganic psychosis NA BeFree Detail
0.007 Malignant neoplasm of prostate Genetic interaction analysis of TCF7L2 for biochemical recurrence after radical ... BeFree,GAD 25678841 Detail
<0.001 Non-alcoholic Fatty Liver Disease NA BeFree Detail
<0.001 Chronic Kidney Insufficiency Is TCF7L2 variant associated with non-diabetic chronic kidney disease progressio... BeFree 24864085 Detail
<0.001 Developmental delay (disorder) NA BeFree Detail
0.001 endometrial carcinoma NA BeFree Detail
0.003 Overweight NA BeFree,GAD Detail
0.129 Metabolic syndrome X NA BeFree,GAD,GWASCAT Detail
<0.001 Thyroid carcinoma NA BeFree Detail
<0.001 Cerebral metastasis NA BeFree Detail
<0.001 primary sclerosing cholangitis NA BeFree Detail
0.018 Diabetes These polymorphisms together with KCNJ11 (Kir6.2)-E23K and TCF7L2-rs7903146 may ... BeFree 17977958 Detail
0.045 diabetes mellitus These polymorphisms together with KCNJ11 (Kir6.2)-E23K and TCF7L2-rs7903146 may ... BeFree 17977958 Detail
0.614 Diabetes Mellitus, Non-Insulin-Dependent Given the phenotypic overlap between PCOS and T2DM, our objective was to investi... BeFree 18958766 Detail
0.007 Carcinogenesis NA BeFree Detail
0.002 prostate carcinoma Genetic interaction analysis of TCF7L2 for biochemical recurrence after radical ... BeFree 25678841 Detail
<0.001 toxic shock syndrome NA BeFree Detail
0.004 breast carcinoma TCF7L2 gene polymorphisms and susceptibility to breast cancer: a meta-analysis. BeFree 25867435 Detail
0.001 Carcinoma of lung NA BeFree Detail
<0.001 Malignant neoplasm of gastrointestinal tract NA BeFree Detail
<0.001 Secondary malignant neoplasm of lymph node NA BeFree Detail
0.004 colon carcinoma TCF4 silencing sensitizes the colon cancer cell line to oxaliplatin as a common ... BeFree 24869759 Detail
0.004 colon carcinoma Thus, the HNF4α isoforms play distinct roles in colon cancer, which could be due... BeFree 26240283 Detail
<0.001 stomach carcinoma Moreover, the expression of WISP3 was positively correlated with the expression ... BeFree 25400723 Detail
<0.001 Malignant neoplasm of kidney NA BeFree Detail
<0.001 Psychotic symptom NA BeFree Detail
<0.001 latent infection NA BeFree Detail
<0.001 Advanced cancer Together, our results establish the LIN28B/TCF7L2 interaction loop as a central ... BeFree 25744721 Detail
0.002 Microsatellite Instability NA GAD Detail
<0.001 Malignant neoplasm of ovary NA BeFree Detail
<0.001 Intestinal Polyposis NA BeFree Detail
<0.001 Abnormal breathing NA BeFree Detail
<0.001 High Grade Intraepithelial Neoplasia NA BeFree Detail
<0.001 renal carcinoma NA BeFree Detail
0.003 Mammary Neoplasms NA LHGDN Detail
<0.001 Neurodevelopmental Disorders To demonstrate adult brain function, we performed expression analyses and ChIPse... BeFree 26194112 Detail
<0.001 Chronic Kidney Diseases Is TCF7L2 variant associated with non-diabetic chronic kidney disease progressio... BeFree 24864085 Detail
<0.001 Glioblastoma multiforme NA BeFree Detail
<0.001 Peripheral Arterial Diseases NA BeFree Detail
<0.001 CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 2 NA BeFree Detail
0.006 coronary artery disease NA BeFree,GAD Detail
<0.001 Latent autoimmune diabetes mellitus in adult NA BeFree Detail
0.002 Precursor Cell Lymphoblastic Leukemia Lymphoma NA GAD Detail
0.007 Pitt-Hopkins syndrome NA BeFree Detail
<0.001 low grade glioma NA BeFree Detail
0.004 liver carcinoma NA BeFree Detail
<0.001 Corneal dystrophy, Fuchs endothelial, 3 NA BeFree Detail
0.002 Weight Loss Adverse Event NA GAD Detail
<0.001 Hirschsprung disease 1 NA BeFree Detail
<0.001 Nonalcoholic Steatohepatitis NA BeFree Detail
0.120 Juvenile arthritis NA CTD_human Detail
<0.001 intellectual disability NA BeFree Detail
0.121 adenocarcinoma NA BeFree,CTD_human Detail
0.004 adenoma NA BeFree,LHGDN Detail
0.002 Alzheimer's disease NA GAD Detail
0.002 arteriosclerosis NA BeFree Detail
<0.001 Astrocytoma NA BeFree Detail
0.016 atherosclerosis NA BeFree,GAD Detail
0.002 Autoimmune Diseases NA GAD Detail
<0.001 Mental disorders NA BeFree Detail
<0.001 Brain Neoplasms NA BeFree Detail
0.127 Malignant neoplasm of breast TCF7L2 gene polymorphisms and susceptibility to breast cancer: a meta-analysis. BeFree,GAD,GWASCAT 25867435 Detail
0.002 calcinosis NA GAD Detail
0.004 Malignant tumor of colon TCF4 silencing sensitizes the colon cancer cell line to oxaliplatin as a common ... BeFree 24869759 Detail
0.004 Malignant tumor of colon Thus, the HNF4α isoforms play distinct roles in colon cancer, which could be due... BeFree 26240283 Detail
<0.001 Rectal Carcinoma The prognostic role of TCF4 expression in locally advanced rectal cancer patient... BeFree 25519018 Detail
<0.001 renal cell carcinoma NA BeFree Detail
Annotation

Annotations

DescrptionSourceLinks
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Interestingly, genetic signals from both T1D and T2D are also seen in LADA, including the key HLA an... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Transcription factor 7-like 2 polymorphisms and diabetic retinopathy: a systematic review. DisGeNET Detail
The gene polymorphisms of UCP1 but not PPAR γ and TCF7L2 are associated with diabetic retinopathy in... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Immunohistochemical analyses revealed that TCF7L2 is differentially expressed and distributed in nor... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Association of common variants in TCF4 and PTPRG with Fuchs' corneal dystrophy: a systematic review ... DisGeNET Detail
Among the several genes and loci associated with FECD, the strongest association is with an intronic... DisGeNET Detail
TCF4 Triplet Repeat Expansion and Nuclear RNA Foci in Fuchs' Endothelial Corneal Dystrophy. DisGeNET Detail
Association of TCF4 polymorphisms and Fuchs' endothelial dystrophy: a meta-analysis. DisGeNET Detail
Expansion of CTG18.1 Trinucleotide Repeat in TCF4 Is a Potent Driver of Fuchs' Corneal Dystrophy. DisGeNET Detail
Trinucleotide Repeat Expansion in the TCF4 Gene in Fuchs' Endothelial Corneal Dystrophy in Japanese. DisGeNET Detail
NA DisGeNET Detail
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These TFs are AR, EGR1, MYC, TCF4, ATF3, JUN, FOXO3, STAT1, HIF1A and EOMES, where ATF3, TCF4 and MY... DisGeNET Detail
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Linagliptin significantly improved hyperglycaemia in patients with type 2 diabetes both with and wit... DisGeNET Detail
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Moreover, the expression of WISP3 was positively correlated with the expression of cyclin D1 and TCF... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
IKKβ Enforces a LIN28B/TCF7L2 Positive Feedback Loop That Promotes Cancer Cell Stemness and Metastas... DisGeNET Detail
Thus, we evaluated the association of 17 single-nucleotide polymorphisms (SNPs) in immune response g... DisGeNET Detail
NA DisGeNET Detail
Immunohistochemical analyses revealed that TCF7L2 is differentially expressed and distributed in nor... DisGeNET Detail
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Interestingly, the persistent overexpression of Tcf7l2 in non-pancreatic tissues results in a signif... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
KCNJ11 Lys23Glu and TCF7L2 rs290487(C/T) polymorphisms affect therapeutic efficacy of repaglinide in... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 ... DisGeNET Detail
NA DisGeNET Detail
Genetic interaction analysis of TCF7L2 for biochemical recurrence after radical prostatectomy in loc... DisGeNET Detail
NA DisGeNET Detail
Is TCF7L2 variant associated with non-diabetic chronic kidney disease progression? Results of a fami... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
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NA DisGeNET Detail
These polymorphisms together with KCNJ11 (Kir6.2)-E23K and TCF7L2-rs7903146 may predict diabetes inc... DisGeNET Detail
These polymorphisms together with KCNJ11 (Kir6.2)-E23K and TCF7L2-rs7903146 may predict diabetes inc... DisGeNET Detail
Given the phenotypic overlap between PCOS and T2DM, our objective was to investigate whether the TCF... DisGeNET Detail
NA DisGeNET Detail
Genetic interaction analysis of TCF7L2 for biochemical recurrence after radical prostatectomy in loc... DisGeNET Detail
NA DisGeNET Detail
TCF7L2 gene polymorphisms and susceptibility to breast cancer: a meta-analysis. DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
TCF4 silencing sensitizes the colon cancer cell line to oxaliplatin as a common chemotherapeutic dru... DisGeNET Detail
Thus, the HNF4α isoforms play distinct roles in colon cancer, which could be due to differential int... DisGeNET Detail
Moreover, the expression of WISP3 was positively correlated with the expression of cyclin D1 and TCF... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Together, our results establish the LIN28B/TCF7L2 interaction loop as a central mediator of cancer s... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
To demonstrate adult brain function, we performed expression analyses and ChIPseq in human neural st... DisGeNET Detail
Is TCF7L2 variant associated with non-diabetic chronic kidney disease progression? Results of a fami... DisGeNET Detail
NA DisGeNET Detail
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TCF7L2 gene polymorphisms and susceptibility to breast cancer: a meta-analysis. DisGeNET Detail
NA DisGeNET Detail
TCF4 silencing sensitizes the colon cancer cell line to oxaliplatin as a common chemotherapeutic dru... DisGeNET Detail
Thus, the HNF4α isoforms play distinct roles in colon cancer, which could be due to differential int... DisGeNET Detail
The prognostic role of TCF4 expression in locally advanced rectal cancer patients treated with neoad... DisGeNET Detail
NA DisGeNET Detail

Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs386597997 dbSNP
Genome
hg38
Position
chr10:112,950,247-113,167,678
Variant Type
snv
Genome browser