chr16:11254417:> Detail (hg38)

Information

Genome

Assembly Position
hg19 chr16:11,348,274-11,350,061 
hg38 chr16:11,254,417-11,256,204

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.003 squamous cell carcinoma NA BeFree,LHGDN Detail
0.002 celiac disease NA GAD Detail
<0.001 Malignant tumor of cervix NA BeFree Detail
<0.001 Primary biliary cirrhosis NA BeFree Detail
0.004 ulcerative colitis No association between the SOCS-1 -1478CA/del polymorphism and ulcerative coliti... BeFree,LHGDN 24985978 Detail
0.004 ulcerative colitis MiR-155 modulates the inflammatory phenotype of intestinal myofibroblasts by tar... BeFree,LHGDN 25998827 Detail
0.001 colorectal carcinoma NA BeFree Detail
0.003 Colorectal Neoplasms NA LHGDN Detail
<0.001 craniopharyngioma NA BeFree Detail
0.120 Crohn Disease NA GWASCAT Detail
<0.001 Dermatitis, Atopic Positive correlations were found between miR-155 expression and AD severity, Th1... BeFree 25761610 Detail
<0.001 Diabetes NA BeFree Detail
<0.001 diabetes mellitus NA BeFree Detail
0.006 Diabetes Mellitus, Insulin-Dependent NA BeFree,GAD Detail
0.003 Diabetes Mellitus, Non-Insulin-Dependent NA BeFree,GAD Detail
<0.001 Eczema Positive correlations were found between miR-155 expression and AD severity, Th1... BeFree 25761610 Detail
<0.001 Filarial Elephantiases NA BeFree Detail
<0.001 Enterovirus Infections NA BeFree Detail
0.003 glioblastoma NA BeFree,LHGDN Detail
<0.001 Severe Dengue Augmented miR-150 expression associated with depressed SOCS1 expression involved... BeFree 24907421 Detail
<0.001 hepatitis NA BeFree Detail
<0.001 hepatitis A NA BeFree Detail
0.001 hepatitis B An integrated analysis of SOCS1 down-regulation in HBV infection-related hepatoc... BeFree 23941364 Detail
0.001 hepatitis B These data indicate that SOCS1 polymorphisms might affect the susceptibility and... BeFree 24768946 Detail
0.003 hepatitis C NA BeFree,GAD Detail
0.003 Herpes Simplex Infections NA BeFree,LHGDN Detail
0.001 HIV Infections NA BeFree Detail
0.009 Hodgkin Disease NA BeFree,LHGDN Detail
0.003 Inflammation NA LHGDN Detail
<0.001 influenza NA BeFree Detail
0.002 Insulin resistance NA GAD Detail
<0.001 leprosy Besides confirming all previously published loci, we discovered six new suscepti... BeFree 25642632 Detail
0.001 leukemia NA BeFree Detail
<0.001 chronic lymphocytic leukemia NA BeFree Detail
0.002 Leukemia, Myelocytic, Acute NA BeFree Detail
0.006 Myeloid Leukemia, Chronic NA BeFree,GAD,LHGDN Detail
<0.001 Leukemia, Myeloid, Chronic-Phase NA BeFree Detail
<0.001 Leukemia, T-Cell NA BeFree Detail
0.003 Adult T-Cell Lymphoma/Leukemia NA BeFree,LHGDN Detail
<0.001 Leukoencephalopathy, Progressive Multifocal NA BeFree Detail
0.001 liver cirrhosis We found high frequencies of SOCS1 gene hypermethylation in both tumour (56.03%)... BeFree 23941364 Detail
0.120 Liver Cirrhosis, Experimental NA CTD_human Detail
0.120 Liver diseases NA CTD_human Detail
<0.001 Liver neoplasms NA BeFree Detail
0.120 Liver Neoplasms, Experimental NA CTD_human Detail
0.001 Lupus Erythematosus, Systemic NA BeFree Detail
0.003 lymphadenitis NA LHGDN Detail
0.004 lymphoma NA BeFree,LHGDN Detail
<0.001 Lymphoma, Follicular NA BeFree Detail
0.001 Malignant neoplasm of stomach Low expression of SOCS-1 and SOCS-3 is a poor prognostic indicator for gastric c... BeFree 25261987 Detail
0.001 Malignant neoplasm of stomach Gene therapy with SOCS1 for gastric cancer induces G2/M arrest and has an antitu... BeFree 26180928 Detail
0.007 melanoma Effects of suppressor of cytokine signaling 1 silencing on human melanoma cell p... BeFree,LHGDN 25322862 Detail
<0.001 mitral valve stenosis NA BeFree Detail
0.011 multiple myeloma Additionally, t-anti-miR-155 significantly increased CD19 positive cell numbers,... BeFree,LHGDN 25185784 Detail
0.001 multiple sclerosis Our results revealed that, SOCS1 mRNA overexpressed (24.5 times) in MS patients ... BeFree 25701091 Detail
<0.001 myelofibrosis NA BeFree Detail
0.007 Myeloproliferative disease NA BeFree,LHGDN Detail
0.080 myocardial infarction NA RGD Detail
<0.001 Neoplasm Metastasis NA BeFree Detail
<0.001 Melanocytic nevus NA BeFree Detail
0.083 obesity During influenza infection, SOCS1 and SOCS3 expression was higher in the lean in... BeFree,GAD,RGD 24182768 Detail
0.003 Degenerative polyarthritis NA BeFree,GAD Detail
<0.001 ovarian carcinoma NA BeFree Detail
0.003 Pancreatic Neoplasm NA LHGDN Detail
<0.001 pituitary adenoma NA BeFree Detail
0.003 Pituitary Neoplasms NA LHGDN Detail
<0.001 plasmacytoma NA BeFree Detail
<0.001 polycythemia NA BeFree Detail
<0.001 polycythemia vera NA BeFree Detail
<0.001 polyps NA BeFree Detail
<0.001 Preleukemia NA BeFree Detail
0.120 psoriasis NA BeFree,GWASCAT Detail
0.003 pulmonary fibrosis NA LHGDN Detail
0.120 Reperfusion Injury NA CTD_human Detail
<0.001 seminoma NA BeFree Detail
<0.001 Dermatologic disorders NA BeFree Detail
<0.001 Skin lesion Positive correlations were found between miR-155 expression and AD severity, Th1... BeFree 25761610 Detail
<0.001 ankylosing spondylitis NA BeFree Detail
0.003 status epilepticus NA LHGDN Detail
<0.001 Stomach Neoplasms SOCS-1 and SOCS-3 mRNA expression levels were lower in gastric tumor tissues tha... BeFree 25261987 Detail
<0.001 Thrombocythemia, Essential NA BeFree Detail
0.003 tuberculosis NA BeFree,LHGDN Detail
<0.001 Tuberculosis, Pulmonary NA BeFree Detail
<0.001 uveitis NA BeFree Detail
<0.001 Virus Diseases Genetic variations of SOCS1 are associated with chronic hepatitis B virus infect... BeFree 24768946 Detail
0.009 B-Cell Lymphomas NA BeFree,LHGDN Detail
<0.001 diffuse large B-cell lymphoma NA BeFree Detail
<0.001 ovarian hyperstimulation syndrome Interleukin-2 and SOCS-1 proteins involvement in the pathophysiology of severe o... BeFree 25424734 Detail
<0.001 Liver failure Prognoses of patients with acute-on-chronic hepatitis B liver failure are closel... BeFree 24727541 Detail
<0.001 Liver failure The degree of methylation of the SOCS1 in ACHBLF patients (35.0%, 21/60) was sig... BeFree 25045829 Detail
<0.001 Active tuberculosis The differential expression levels of TLR2, BIC, and SOCS1 were involved in regu... BeFree 25721573 Detail
0.120 Dermatitis, Allergic Contact NA CTD_human Detail
<0.001 Tumor Progression NA BeFree Detail
<0.001 Germ cell tumor NA BeFree Detail
<0.001 Ki-1+ Anaplastic Large Cell Lymphoma To investigate its function, we over-expressed miR-155 in ALCL ALK(+) cell lines... BeFree 25820993 Detail
0.003 hepatoblastoma NA BeFree,LHGDN Detail
<0.001 Neuroendocrine Tumors NA BeFree Detail
<0.001 Metastatic malignant neoplasm to brain NA BeFree Detail
<0.001 pancreatic carcinoma NA BeFree Detail
<0.001 Fibrosis, Liver NA BeFree Detail
<0.001 Malignant neoplasm of lung NA BeFree Detail
0.080 Sepsis NA RGD Detail
<0.001 Rhinovirus infection We report induction of SOCS1 in bronchial epithelial cells (BECs) by asthma exac... BeFree 25630941 Detail
<0.001 Metastatic melanoma NA BeFree Detail
<0.001 cervical squamous cell carcinoma NA BeFree Detail
<0.001 Solid tumour NA BeFree Detail
<0.001 laryngeal squamous cell carcinoma NA BeFree Detail
0.001 cervix carcinoma NA BeFree Detail
<0.001 Fulminant hepatitis Suppressor of cytokine signalling 1 (SOCS1) was demonstrated to play an importan... BeFree 25045829 Detail
<0.001 Hyperplastic Polyp NA BeFree Detail
<0.001 Chronic liver disease NA BeFree Detail
<0.001 Malignant neoplasm of pancreas NA BeFree Detail
<0.001 juvenile myelomonocytic leukemia NA BeFree Detail
<0.001 Malignant neoplasm of prostate NA BeFree Detail
<0.001 Hematologic Neoplasms The inactivation of suppressor of cytokine signaling SOCS-1, a negative regulato... BeFree 25123164 Detail
<0.001 Hereditary hemochromatosis NA BeFree Detail
<0.001 Chronic Kidney Insufficiency NA BeFree Detail
0.003 Hepatitis B, Chronic Prognoses of patients with acute-on-chronic hepatitis B liver failure are closel... BeFree,LHGDN 24727541 Detail
0.003 Hepatitis B, Chronic Genetic variations of SOCS1 are associated with chronic hepatitis B virus infect... BeFree,LHGDN 24768946 Detail
<0.001 Hepatitis C, Chronic NA BeFree Detail
<0.001 Thyroid carcinoma NA BeFree Detail
0.003 Carcinogenesis NA BeFree Detail
<0.001 prostate carcinoma NA BeFree Detail
<0.001 invasive cancer NA BeFree Detail
<0.001 breast carcinoma NA BeFree Detail
<0.001 Carcinoma of lung NA BeFree Detail
0.007 Myeloproliferative disease SOCS1 expression was raised in myeloproliferative disorder granulocytes but the ... BeFree 18815196 Detail
<0.001 Chronic myeloproliferative disorder SOCS1 expression was raised in myeloproliferative disorder granulocytes but the ... BeFree 18815196 Detail
<0.001 Secondary malignant neoplasm of lymph node NA BeFree Detail
<0.001 colon carcinoma NA BeFree Detail
0.002 stomach carcinoma Low expression of SOCS-1 and SOCS-3 is a poor prognostic indicator for gastric c... BeFree 25261987 Detail
0.002 stomach carcinoma Gene therapy with SOCS1 for gastric cancer induces G2/M arrest and has an antitu... BeFree 26180928 Detail
<0.001 Carcinoma of bladder NA BeFree Detail
<0.001 Multiple Sclerosis, Relapsing-Remitting Expression of suppressor of cytokine signaling 1 (SOCS1) gene dramatically incre... BeFree 25701091 Detail
<0.001 malignant pleural mesothelioma NA BeFree Detail
<0.001 Rhabdoid Tumor of the Kidney NA BeFree Detail
<0.001 Acute coronary syndrome NA BeFree Detail
<0.001 Malignant neoplasm of ovary NA BeFree Detail
<0.001 Squamous cell carcinoma of the head and neck NA BeFree Detail
<0.001 Ductal Carcinoma NA BeFree Detail
<0.001 Mediastinal (Thymic) Large B-Cell Lymphoma NA BeFree Detail
<0.001 Precursor B-cell lymphoblastic leukemia NA BeFree Detail
<0.001 Chronic myeloproliferative disorder NA BeFree Detail
<0.001 Pancreatic intraepithelial neoplasia NA BeFree Detail
<0.001 Classical Hodgkin's Lymphoma NA BeFree Detail
0.005 Mammary Neoplasms NA LHGDN Detail
0.001 Hepatocarcinogenesis NA BeFree Detail
0.002 colorectal cancer NA BeFree Detail
<0.001 Pneumocystis jiroveci pneumonia NA BeFree Detail
<0.001 Chronic Kidney Diseases NA BeFree Detail
<0.001 Glioblastoma multiforme NA BeFree Detail
0.001 Cirrhosis We found high frequencies of SOCS1 gene hypermethylation in both tumour (56.03%)... BeFree 23941364 Detail
0.003 Idiopathic Pulmonary Fibrosis Expression of suppressor of cytokine signaling 1 in the peripheral blood of pati... BeFree,LHGDN 24890164 Detail
<0.001 campomelic dysplasia NA BeFree Detail
0.015 liver carcinoma An integrated analysis of SOCS1 down-regulation in HBV infection-related hepatoc... BeFree,LHGDN 23941364 Detail
<0.001 Promyelocytic leukemia NA BeFree Detail
<0.001 Treatment related leukaemia NA BeFree Detail
<0.001 myelodysplastic syndrome NA BeFree Detail
<0.001 adenocarcinoma NA BeFree Detail
<0.001 Primary myelofibrosis NA BeFree Detail
0.002 Alzheimer's disease NA GAD Detail
<0.001 Refractory anaemia with excess blasts This may be due to high association between SOCS1 methylation and higher risk su... BeFree 25123164 Detail
<0.001 arteriosclerosis NA BeFree Detail
0.004 rheumatoid arthritis NA BeFree,GAD Detail
0.008 asthma Increased nuclear suppressor of cytokine signaling 1 in asthmatic bronchial epit... BeFree,GAD,LHGDN 25630941 Detail
<0.001 atherosclerosis NA BeFree Detail
<0.001 Autoimmune Diseases NA BeFree Detail
<0.001 Malignant neoplasm of urinary bladder NA BeFree Detail
<0.001 Malignant neoplasm of breast NA BeFree Detail
0.001 Malignant tumor of colon NA BeFree Detail
<0.001 Malignant neoplasm of thyroid NA BeFree Detail
<0.001 Non-small cell lung carcinoma MicroRNA-19a functions as an oncogenic microRNA in non-small cell lung cancer by... BeFree 25604748 Detail
<0.001 renal cell carcinoma NA BeFree Detail
Annotation

Annotations

DescrptionSourceLinks
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
No association between the SOCS-1 -1478CA/del polymorphism and ulcerative colitis in Turkish subject... DisGeNET Detail
MiR-155 modulates the inflammatory phenotype of intestinal myofibroblasts by targeting SOCS1 in ulce... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Positive correlations were found between miR-155 expression and AD severity, Th17 cell percentage, R... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Positive correlations were found between miR-155 expression and AD severity, Th17 cell percentage, R... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Augmented miR-150 expression associated with depressed SOCS1 expression involved in dengue haemorrha... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
An integrated analysis of SOCS1 down-regulation in HBV infection-related hepatocellular carcinoma. DisGeNET Detail
These data indicate that SOCS1 polymorphisms might affect the susceptibility and outcome of HBV infe... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Besides confirming all previously published loci, we discovered six new susceptibility loci, and fur... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
We found high frequencies of SOCS1 gene hypermethylation in both tumour (56.03%) and adjacent nontum... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Low expression of SOCS-1 and SOCS-3 is a poor prognostic indicator for gastric cancer patients. DisGeNET Detail
Gene therapy with SOCS1 for gastric cancer induces G2/M arrest and has an antitumour effect on perit... DisGeNET Detail
Effects of suppressor of cytokine signaling 1 silencing on human melanoma cell proliferation and int... DisGeNET Detail
NA DisGeNET Detail
Additionally, t-anti-miR-155 significantly increased CD19 positive cell numbers, which are novel bio... DisGeNET Detail
Our results revealed that, SOCS1 mRNA overexpressed (24.5 times) in MS patients versus healthy contr... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
During influenza infection, SOCS1 and SOCS3 expression was higher in the lean infected volunteers in... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Positive correlations were found between miR-155 expression and AD severity, Th17 cell percentage, R... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
SOCS-1 and SOCS-3 mRNA expression levels were lower in gastric tumor tissues than in matched normal ... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Genetic variations of SOCS1 are associated with chronic hepatitis B virus infection. DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Interleukin-2 and SOCS-1 proteins involvement in the pathophysiology of severe ovarian hyperstimulat... DisGeNET Detail
Prognoses of patients with acute-on-chronic hepatitis B liver failure are closely associated with al... DisGeNET Detail
The degree of methylation of the SOCS1 in ACHBLF patients (35.0%, 21/60) was significantly higher th... DisGeNET Detail
The differential expression levels of TLR2, BIC, and SOCS1 were involved in regulating the immune re... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
To investigate its function, we over-expressed miR-155 in ALCL ALK(+) cell lines and demonstrated re... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
We report induction of SOCS1 in bronchial epithelial cells (BECs) by asthma exacerbation-related cyt... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Suppressor of cytokine signalling 1 (SOCS1) was demonstrated to play an important negative role in f... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
The inactivation of suppressor of cytokine signaling SOCS-1, a negative regulator of cytokine pathwa... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Prognoses of patients with acute-on-chronic hepatitis B liver failure are closely associated with al... DisGeNET Detail
Genetic variations of SOCS1 are associated with chronic hepatitis B virus infection. DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
SOCS1 expression was raised in myeloproliferative disorder granulocytes but the level was independen... DisGeNET Detail
SOCS1 expression was raised in myeloproliferative disorder granulocytes but the level was independen... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Low expression of SOCS-1 and SOCS-3 is a poor prognostic indicator for gastric cancer patients. DisGeNET Detail
Gene therapy with SOCS1 for gastric cancer induces G2/M arrest and has an antitumour effect on perit... DisGeNET Detail
NA DisGeNET Detail
Expression of suppressor of cytokine signaling 1 (SOCS1) gene dramatically increases in relapsing-re... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
We found high frequencies of SOCS1 gene hypermethylation in both tumour (56.03%) and adjacent nontum... DisGeNET Detail
Expression of suppressor of cytokine signaling 1 in the peripheral blood of patients with idiopathic... DisGeNET Detail
NA DisGeNET Detail
An integrated analysis of SOCS1 down-regulation in HBV infection-related hepatocellular carcinoma. DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
This may be due to high association between SOCS1 methylation and higher risk subtypes of MDS (such ... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Increased nuclear suppressor of cytokine signaling 1 in asthmatic bronchial epithelium suppresses rh... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
MicroRNA-19a functions as an oncogenic microRNA in non-small cell lung cancer by targeting the suppr... DisGeNET Detail
NA DisGeNET Detail

Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs386626619 dbSNP
Genome
hg38
Position
chr16:11,254,417-11,256,204
Variant Type
snv
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