chr19:13049423:> Detail (hg19) (CALR)

Information

Genome

Assembly Position
hg19 chr19:13,049,423-13,055,303
hg38 chr19:12,938,609-12,944,489 

HGVS

Type Transcript Protein
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

[No Data.]

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
Disease Drug EL ET ED CS VO TR Pubmed Links
essential thrombocythemia A Diagnostic Supports Positive Somatic 5 27069254 Detail
DisGeNET
Score Disease name Description Source Pubmed Links
<0.001 squamous cell carcinoma We previously revealed that the calreticulin (CRT) gene is a candidate oncogene ... BeFree 25231404 Detail
<0.001 squamous cell carcinoma Adenosquamous carcinoma of the head and neck: Molecular analysis using CRTC-MAML... BeFree 26255977 Detail
<0.001 Cardiomyopathy, Dilated NA BeFree Detail
<0.001 Malignant tumor of cervix NA BeFree Detail
0.003 Colonic Neoplasms NA LHGDN Detail
0.001 colorectal carcinoma To accurately analyze the association between the histological types and molecul... BeFree 25110432 Detail
0.120 Colorectal Neoplasms NA CTD_human Detail
<0.001 eclampsia NA BeFree Detail
<0.001 Esophageal Neoplasms Calreticulin promotes migration and invasion of esophageal cancer cells by upreg... BeFree 25231404 Detail
<0.001 Exanthema NA BeFree Detail
0.080 Fibrosis NA RGD Detail
<0.001 Gastrointestinal Neoplasms Moreover, Honokiol significantly suppressed MNNG-induced gastrointestinal tumor ... BeFree 25619450 Detail
<0.001 glioblastoma NA BeFree Detail
0.003 Glioma NA BeFree,LHGDN Detail
<0.001 Graves Disease NA BeFree Detail
<0.001 Heart block NA BeFree Detail
<0.001 Heart failure NA BeFree Detail
<0.001 congestive heart failure NA BeFree Detail
<0.001 heart valve disease NA BeFree Detail
<0.001 hemochromatosis NA BeFree Detail
<0.001 Hepatitis, Chronic NA BeFree Detail
<0.001 Herpes Simplex Infections NA BeFree Detail
<0.001 HIV Infections NA BeFree Detail
<0.001 Hypercholesterolemia NA BeFree Detail
<0.001 Immunologic Deficiency Syndromes NA BeFree Detail
<0.001 arthropathy NA BeFree Detail
<0.001 Speech and language disorder NA BeFree Detail
<0.001 leukemia NA BeFree Detail
<0.001 chronic lymphocytic leukemia NA BeFree Detail
0.002 Leukemia, Myelocytic, Acute We analysed CSF3R exons 14 and 17, and CALR exon 9, using direct sequencing in s... BeFree 25858548 Detail
<0.001 chronic neutrophilic leukemia CSF3R, SETBP1 and CALR mutations in chronic neutrophilic leukemia. BeFree 25316523 Detail
<0.001 liposarcoma NA BeFree Detail
<0.001 liver cirrhosis NA BeFree Detail
<0.001 Lupus Vulgaris NA BeFree Detail
<0.001 Lupus Erythematosus, Discoid NA BeFree Detail
0.002 Lupus Erythematosus, Systemic NA BeFree Detail
<0.001 Malignant neoplasm of stomach Knockdown CRT in gastric cancer cells was found to effectively reduce growth abi... BeFree 25619450 Detail
0.003 melanoma NA BeFree,LHGDN Detail
0.120 Melanoma, Experimental NA CTD_human Detail
0.005 Myeloproliferative disease Calreticulin: a new horizon for the testing and treatment of myeloproliferative ... BeFree 24849893 Detail
0.005 Myeloproliferative disease Distinct clinical characteristics of myeloproliferative neoplasms with calreticu... BeFree 24895336 Detail
0.005 Myeloproliferative disease The mutation profile of JAK2 and CALR in Chinese Han patients with Philadelphia ... BeFree 25023898 Detail
0.005 Myeloproliferative disease CALR mutations were present in 44% of ET (15/34), 14% of persistent thrombocytos... BeFree 25068507 Detail
0.005 Myeloproliferative disease Myeloproliferative neoplasms (MPNs) are stem cell-derived clonal myeloid maligna... BeFree 25139710 Detail
0.005 Myeloproliferative disease Frequency and molecular characteristics of calreticulin gene (CALR) mutations in... BeFree 25323779 Detail
0.005 Myeloproliferative disease Calreticulin mutations in myeloproliferative neoplasms and new methodology for t... BeFree 25349114 Detail
0.005 Myeloproliferative disease The JAK2 46/1 haplotype does not predispose to CALR-mutated myeloproliferative n... BeFree 25482455 Detail
0.005 Myeloproliferative disease Evaluation of methods to detect CALR mutations in myeloproliferative neoplasms. BeFree 25499808 Detail
0.005 Myeloproliferative disease The mutation profile of JAK2, MPL and CALR in Mexican patients with Philadelphia... BeFree 25637689 Detail
0.005 Myeloproliferative disease In this chapter, we detail the genomic alterations that underlie MPNs, with a fo... BeFree 25696868 Detail
0.005 Myeloproliferative disease Mutations in the colony-stimulating factor 3 receptor (CSF3R) and calreticulin (... BeFree 25858548 Detail
0.005 Myeloproliferative disease The prognostic significance of CALR mutations likely differs among the MPN subty... BeFree 25873496 Detail
0.005 Myeloproliferative disease The true frequency of the JAK2 46/1 haplotype in patients of myeloproliferative ... BeFree 25976465 Detail
0.005 Myeloproliferative disease The combined genetic tests of JAK2 V617F, JAK2 exon 12, MPL exon 10, and CALR ex... BeFree 26071474 Detail
0.005 Myeloproliferative disease ATG2B and GSKIP cooperate with acquired JAK2, MPL and CALR mutations during MPN ... BeFree 26280900 Detail
0.005 Myeloproliferative disease Fourteen samples from 10 patients with JAK2 and MPL wild-type myeloproliferative... BeFree 26486738 Detail
0.005 Myeloproliferative disease Clinical validation of a multipurpose assay for detection and genotyping of CALR... BeFree 26486739 Detail
0.120 Neoplasm Invasiveness NA CTD_human Detail
0.005 Neoplasm Metastasis Our findings suggest that NRP1 is a critical downstream effector of CRT in promo... BeFree,LHGDN 25231404 Detail
0.005 Neoplasm Metastasis The present study provides insight into the specific biological behavior of CRT ... BeFree,LHGDN 25619450 Detail
0.005 Neoplasm Metastasis Here, we reviewed the biological roles of calreticulin and summarized the potent... BeFree,LHGDN 25918716 Detail
<0.001 neuroblastoma NA BeFree Detail
<0.001 onchocerciasis NA BeFree Detail
<0.001 Degenerative polyarthritis NA BeFree Detail
<0.001 ovarian carcinoma NA BeFree Detail
<0.001 pituitary adenoma NA BeFree Detail
<0.001 Pituitary Neoplasms NA BeFree Detail
<0.001 Pleural effusion disorder NA BeFree Detail
<0.001 Adenomatous Polyposis Coli NA BeFree Detail
0.002 polyps NA BeFree Detail
0.003 pre-eclampsia NA LHGDN Detail
<0.001 Preleukemia We analysed CSF3R exons 14 and 17, and CALR exon 9, using direct sequencing in s... BeFree 25858548 Detail
0.120 Prostatic Neoplasms NA BeFree,CTD_human Detail
<0.001 Psychotic Disorders NA BeFree Detail
<0.001 Rectal Neoplasms NA BeFree Detail
<0.001 Rheumatism NA BeFree Detail
<0.001 scarlet fever NA BeFree Detail
<0.001 schizoaffective disorder NA BeFree Detail
<0.001 schizophrenia NA BeFree Detail
<0.001 paranoid schizophrenia NA BeFree Detail
<0.001 Shared Paranoid Disorder NA BeFree Detail
<0.001 Dermatologic disorders NA BeFree Detail
<0.001 Stomach Neoplasms Taken together, our results suggest that the therapeutic inhibition of CRT by Ho... BeFree 25619450 Detail
<0.001 gastric ulcer NA BeFree Detail
<0.001 thyroiditis NA BeFree Detail
<0.001 Chagas disease NA BeFree Detail
<0.001 vitiligo NA BeFree Detail
<0.001 intestinal volvulus NA BeFree Detail
0.004 congenital heart block Only 2% of mothers positive for anti-SSA/Ro (Ro) antibodies have children with c... BeFree 25994441 Detail
0.120 Myocardial Ischemia NA CTD_human Detail
<0.001 esophageal carcinoma Calreticulin promotes migration and invasion of esophageal cancer cells by upreg... BeFree 25231404 Detail
<0.001 Secondary malignant neoplasm of lung NA BeFree Detail
0.001 Tumor Progression NA BeFree Detail
<0.001 Liposarcoma, Dedifferentiated NA BeFree Detail
<0.001 Lung Diseases, Interstitial NA BeFree Detail
<0.001 Adenomatous Polyps NA BeFree Detail
<0.001 Neuroendocrine Tumors NA BeFree Detail
<0.001 Fibrillation NA BeFree Detail
<0.001 pancreatic carcinoma NA BeFree Detail
<0.001 Mucosa-Associated Lymphoid Tissue Lymphoma NA BeFree Detail
<0.001 Rheumatic disease of heart valve NA BeFree Detail
<0.001 Systemic amyloidosis NA BeFree Detail
<0.001 Oculocutaneous albinism type 1 NA BeFree Detail
<0.001 Malignant neoplasm of stomach stage IV CRT was significantly down-regulated in highly metastatic gastric cancer cell li... BeFree 25619450 Detail
<0.001 Metastatic melanoma NA BeFree Detail
0.121 Squamous cell carcinoma of esophagus The expression levels of three genes determined by qPCR provide a possible model... BeFree,CTD_human 24907633 Detail
0.121 Squamous cell carcinoma of esophagus Our findings suggest that NRP1 is a critical downstream effector of CRT in promo... BeFree,CTD_human 25231404 Detail
0.121 Squamous cell carcinoma of esophagus Efficient induction of anti-tumor immune response in esophageal squamous cell ca... BeFree,CTD_human 25863743 Detail
<0.001 Primary Systemic Amyloidosis NA BeFree Detail
<0.001 cervix carcinoma NA BeFree Detail
<0.001 Tumor necrosis NA BeFree Detail
0.003 Hyperplastic Polyp To accurately analyze the association between the histological types and molecul... BeFree 25110432 Detail
<0.001 Multiple polyps NA BeFree Detail
<0.001 Tubulovillous adenoma NA BeFree Detail
<0.001 Acute panmyelosis with myelofibrosis CALR mutations were not found in PV or APMF. BeFree 25873496 Detail
<0.001 Insulin resistance - type A NA BeFree Detail
<0.001 Streptococcal toxic shock syndrome Most isolates had scpA, ska, saga, and slo genes, whereas speC, speG, speH, speI... BeFree 24210866 Detail
<0.001 Neoplasm of ampulla of Vater NA BeFree Detail
<0.001 Malignant neoplasm of pancreas NA BeFree Detail
<0.001 Nonorganic psychosis NA BeFree Detail
<0.001 juvenile myelomonocytic leukemia We analysed CSF3R exons 14 and 17, and CALR exon 9, using direct sequencing in s... BeFree 25858548 Detail
0.001 Malignant neoplasm of prostate NA BeFree Detail
<0.001 Hematologic Neoplasms With the discoveries of underlying mutations in JAK2, MPL, and, most recently, c... BeFree 25696868 Detail
<0.001 Hereditary hemochromatosis NA BeFree Detail
<0.001 lupus erythematosus NA BeFree Detail
0.002 Neonatal Systemic lupus erythematosus NA BeFree Detail
<0.001 Reactive thrombocytosis CALR mutations were present in 44% of ET (15/34), 14% of persistent thrombocytos... BeFree 25068507 Detail
<0.001 Mood Disorders NA BeFree Detail
<0.001 Malignant neoplasm of esophagus Calreticulin promotes migration and invasion of esophageal cancer cells by upreg... BeFree 25231404 Detail
<0.001 Malignant glioma NA BeFree Detail
0.001 Carcinogenesis In addition to immunogenicity and tumorigenesis, interactions between calreticul... BeFree 25918716 Detail
0.248 Thrombocythemia, Essential JAK2/MPL wild-type, CALR mutated hypercellular ET associated with PMGM is featur... BeFree 25116092 Detail
0.001 prostate carcinoma NA BeFree Detail
0.002 polycythemia vera Molecular profiling must include the analysis of JAK2 (looking for the V617F poi... BeFree 25189723 Detail
0.127 Primary myelofibrosis Patients with JAK2 V617F-positive MPN have a heterogeneous histology while CALR-... BeFree 24957246 Detail
0.248 Thrombocythemia, Essential Patients with JAK2 V617F-positive MPN have a heterogeneous histology while CALR-... BeFree 24957246 Detail
0.248 Thrombocythemia, Essential Frequency and allele burden of CALR mutations in Chinese with essential thromboc... BeFree 25746303 Detail
0.248 Thrombocythemia, Essential Calreticulin mutations (CALR(MUT)) are found in a significant proportion of pati... BeFree 25139350 Detail
0.127 Primary myelofibrosis The classical Philadelphia chromosome-negative myeloproliferative neoplasms (MPN... BeFree 25870379 Detail
0.122 myelofibrosis The classical Philadelphia chromosome-negative myeloproliferative neoplasms (MPN... BeFree 25870379 Detail
0.127 Primary myelofibrosis Frequency and allele burden of CALR mutations in Chinese with essential thromboc... BeFree 25746303 Detail
<0.001 Epithelial ovarian cancer NA BeFree Detail
0.248 Thrombocythemia, Essential Molecular profiling must include the analysis of JAK2 (looking for the V617F poi... BeFree 25189723 Detail
0.127 Primary myelofibrosis The recent discovery of mutations within the CALR gene in up to 80% of JAK2 V617... BeFree 25259626 Detail
<0.001 breast carcinoma NA BeFree Detail
0.002 polycythemia vera In the current study, mutations of JAK2 V617F, JAK2 exon 12, MPL exon 10, and CA... BeFree 26071474 Detail
0.122 myelofibrosis This study revealed that CALR mutant essential thrombocythemia is associated wit... BeFree 25934766 Detail
0.127 Primary myelofibrosis This study revealed that CALR mutant essential thrombocythemia is associated wit... BeFree 25934766 Detail
0.127 Primary myelofibrosis Four main molecular types of clonal MPN can be distinguished: JAK2(V617F)-positi... BeFree 25116092 Detail
0.002 polycythemia vera JAK2/MPL wild-type, CALR mutated hypercellular ET associated with PMGM is featur... BeFree 25116092 Detail
<0.001 Secondary malignant neoplasm of lymph node CRT and NRP1 coexpression was significantly associated with lymph node metastasi... BeFree 25231404 Detail
<0.001 colon carcinoma Sessile serrated adenomas/polyps (SSA/Ps) are a putative precursor of colon canc... BeFree 25314065 Detail
<0.001 stomach carcinoma Knockdown CRT in gastric cancer cells was found to effectively reduce growth abi... BeFree 25619450 Detail
<0.001 Carcinoma of bladder NA BeFree Detail
<0.001 Central neuroblastoma NA BeFree Detail
<0.001 thrombocytosis CALR mutations were present in 44% of ET (15/34), 14% of persistent thrombocytos... BeFree 25068507 Detail
<0.001 Spots on skin NA BeFree Detail
<0.001 Mental Retardation, X-Linked NA BeFree Detail
0.002 Traditional Serrated Adenoma With regard to the histological type, the IGF2 DMR0 methylation levels of SSAs (... BeFree 25110432 Detail
0.002 Traditional Serrated Adenoma Then we summarize the clinicopathological features, classification and molecular... BeFree 25263173 Detail
0.002 Traditional Serrated Adenoma The SSA/Ps are more common and are more likely to be flat than TSAs. BeFree 25368744 Detail
<0.001 Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative NA BeFree Detail
0.005 Chronic myeloproliferative disorder Calreticulin: a new horizon for the testing and treatment of myeloproliferative ... BeFree 24849893 Detail
0.005 Chronic myeloproliferative disorder Distinct clinical characteristics of myeloproliferative neoplasms with calreticu... BeFree 24895336 Detail
0.005 Chronic myeloproliferative disorder The mutation profile of JAK2 and CALR in Chinese Han patients with Philadelphia ... BeFree 25023898 Detail
0.005 Chronic myeloproliferative disorder CALR mutations were present in 44% of ET (15/34), 14% of persistent thrombocytos... BeFree 25068507 Detail
0.005 Chronic myeloproliferative disorder Myeloproliferative neoplasms (MPNs) are stem cell-derived clonal myeloid maligna... BeFree 25139710 Detail
0.005 Chronic myeloproliferative disorder Frequency and molecular characteristics of calreticulin gene (CALR) mutations in... BeFree 25323779 Detail
0.005 Chronic myeloproliferative disorder Calreticulin mutations in myeloproliferative neoplasms and new methodology for t... BeFree 25349114 Detail
0.005 Chronic myeloproliferative disorder The JAK2 46/1 haplotype does not predispose to CALR-mutated myeloproliferative n... BeFree 25482455 Detail
0.005 Chronic myeloproliferative disorder Evaluation of methods to detect CALR mutations in myeloproliferative neoplasms. BeFree 25499808 Detail
0.005 Chronic myeloproliferative disorder The mutation profile of JAK2, MPL and CALR in Mexican patients with Philadelphia... BeFree 25637689 Detail
0.005 Chronic myeloproliferative disorder In this chapter, we detail the genomic alterations that underlie MPNs, with a fo... BeFree 25696868 Detail
0.005 Chronic myeloproliferative disorder The prognostic significance of CALR mutations likely differs among the MPN subty... BeFree 25873496 Detail
0.005 Chronic myeloproliferative disorder The true frequency of the JAK2 46/1 haplotype in patients of myeloproliferative ... BeFree 25976465 Detail
0.005 Chronic myeloproliferative disorder The combined genetic tests of JAK2 V617F, JAK2 exon 12, MPL exon 10, and CALR ex... BeFree 26071474 Detail
0.005 Chronic myeloproliferative disorder ATG2B and GSKIP cooperate with acquired JAK2, MPL and CALR mutations during MPN ... BeFree 26280900 Detail
0.005 Chronic myeloproliferative disorder Fourteen samples from 10 patients with JAK2 and MPL wild-type myeloproliferative... BeFree 26486738 Detail
0.005 Chronic myeloproliferative disorder Clinical validation of a multipurpose assay for detection and genotyping of CALR... BeFree 26486739 Detail
<0.001 Ovarian Serous Adenocarcinoma NA BeFree Detail
<0.001 Tumor Immunity NA BeFree Detail
<0.001 colorectal cancer To accurately analyze the association between the histological types and molecul... BeFree 25110432 Detail
<0.001 Sjogren's syndrome Lupus-like manifestations consisted of pericarditis, pleuritis, and positive ant... BeFree 26216333 Detail
<0.001 Rectal Tumors NA BeFree Detail
<0.001 Cirrhosis NA BeFree Detail
<0.001 VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) NA BeFree Detail
<0.001 liver carcinoma NA BeFree Detail
0.003 Sessile Serrated Adenoma/Polyp To accurately analyze the association between the histological types and molecul... BeFree 25110432 Detail
0.003 Sessile Serrated Adenoma/Polyp Then we summarize the clinicopathological features, classification and molecular... BeFree 25263173 Detail
0.003 Sessile Serrated Adenoma/Polyp B-RAF mutation and accumulated gene methylation in aberrant crypt foci (ACF), se... BeFree 25314065 Detail
<0.001 Bisphosphonate-associated osteonecrosis NA BeFree Detail
<0.001 Serrated polyp NA BeFree Detail
<0.001 myelodysplastic syndrome We analysed CSF3R exons 14 and 17, and CALR exon 9, using direct sequencing in s... BeFree 25858548 Detail
0.003 adenocarcinoma NA BeFree,LHGDN Detail
0.002 adenoma NA BeFree Detail
<0.001 Albinism NA BeFree Detail
<0.001 Alzheimer's disease Serum calreticulin is a negative biomarker in patients with Alzheimer's disease. BeFree 25429433 Detail
<0.001 Anaplasia NA BeFree Detail
<0.001 anemia Patients with CALR mutation had a lower risk of developing anemia, thrombocytope... BeFree 24986690 Detail
<0.001 anthrax disease NA BeFree Detail
<0.001 rheumatoid arthritis NA BeFree Detail
<0.001 Astrocytoma NA BeFree Detail
<0.001 Autoimmune Diseases NA BeFree Detail
<0.001 Mental disorders NA BeFree Detail
<0.001 bipolar disorder NA BeFree Detail
<0.001 Malignant neoplasm of urinary bladder NA BeFree Detail
0.003 Bladder Neoplasm NA LHGDN Detail
<0.001 Blast Phase Patients with CALR-mutated ET more frequently progressed to the accelerated or b... BeFree 25873496 Detail
<0.001 Malignant neoplasm of breast NA BeFree Detail
0.001 Malignant tumor of colon Sessile serrated adenomas/polyps (SSA/Ps) are a putative precursor of colon canc... BeFree 25314065 Detail
<0.001 Rectal Carcinoma NA BeFree Detail
Annotation

Annotations

DescrptionSourceLinks
Diagnostic criterion for essential thrombocytemia according to the World Health Organization (WHO) c... CIViC Evidence Detail
We previously revealed that the calreticulin (CRT) gene is a candidate oncogene promoting cell migra... DisGeNET Detail
Adenosquamous carcinoma of the head and neck: Molecular analysis using CRTC-MAML FISH and survival c... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
To accurately analyze the association between the histological types and molecular features of each ... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Calreticulin promotes migration and invasion of esophageal cancer cells by upregulating neuropilin-1... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Moreover, Honokiol significantly suppressed MNNG-induced gastrointestinal tumor growth and over-expr... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
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NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
We analysed CSF3R exons 14 and 17, and CALR exon 9, using direct sequencing in samples of paediatric... DisGeNET Detail
CSF3R, SETBP1 and CALR mutations in chronic neutrophilic leukemia. DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Knockdown CRT in gastric cancer cells was found to effectively reduce growth ability and metastasis ... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Calreticulin: a new horizon for the testing and treatment of myeloproliferative neoplasms. DisGeNET Detail
Distinct clinical characteristics of myeloproliferative neoplasms with calreticulin mutations. DisGeNET Detail
The mutation profile of JAK2 and CALR in Chinese Han patients with Philadelphia chromosome-negative ... DisGeNET Detail
CALR mutations were present in 44% of ET (15/34), 14% of persistent thrombocytosis suggestive of MPN... DisGeNET Detail
Myeloproliferative neoplasms (MPNs) are stem cell-derived clonal myeloid malignancies characterized ... DisGeNET Detail
Frequency and molecular characteristics of calreticulin gene (CALR) mutations in patients with JAK2 ... DisGeNET Detail
Calreticulin mutations in myeloproliferative neoplasms and new methodology for their detection and m... DisGeNET Detail
The JAK2 46/1 haplotype does not predispose to CALR-mutated myeloproliferative neoplasms. DisGeNET Detail
Evaluation of methods to detect CALR mutations in myeloproliferative neoplasms. DisGeNET Detail
The mutation profile of JAK2, MPL and CALR in Mexican patients with Philadelphia chromosome-negative... DisGeNET Detail
In this chapter, we detail the genomic alterations that underlie MPNs, with a focus on the recent di... DisGeNET Detail
Mutations in the colony-stimulating factor 3 receptor (CSF3R) and calreticulin (CALR) genes have bee... DisGeNET Detail
The prognostic significance of CALR mutations likely differs among the MPN subtypes. DisGeNET Detail
The true frequency of the JAK2 46/1 haplotype in patients of myeloproliferative neoplasms (MPN) with... DisGeNET Detail
The combined genetic tests of JAK2 V617F, JAK2 exon 12, MPL exon 10, and CALR exon 9 help improve th... DisGeNET Detail
ATG2B and GSKIP cooperate with acquired JAK2, MPL and CALR mutations during MPN development. DisGeNET Detail
Fourteen samples from 10 patients with JAK2 and MPL wild-type myeloproliferative neoplasms were posi... DisGeNET Detail
Clinical validation of a multipurpose assay for detection and genotyping of CALR mutations in myelop... DisGeNET Detail
NA DisGeNET Detail
Our findings suggest that NRP1 is a critical downstream effector of CRT in promoting cell migration ... DisGeNET Detail
The present study provides insight into the specific biological behavior of CRT in epithelial-to-mes... DisGeNET Detail
Here, we reviewed the biological roles of calreticulin and summarized the potential mechanisms of ca... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
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We analysed CSF3R exons 14 and 17, and CALR exon 9, using direct sequencing in samples of paediatric... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Taken together, our results suggest that the therapeutic inhibition of CRT by Honokiol suppresses bo... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
Only 2% of mothers positive for anti-SSA/Ro (Ro) antibodies have children with congenital heart bloc... DisGeNET Detail
NA DisGeNET Detail
Calreticulin promotes migration and invasion of esophageal cancer cells by upregulating neuropilin-1... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
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CRT was significantly down-regulated in highly metastatic gastric cancer cell lines and metastatic a... DisGeNET Detail
NA DisGeNET Detail
The expression levels of three genes determined by qPCR provide a possible model for ESCC CRT predic... DisGeNET Detail
Our findings suggest that NRP1 is a critical downstream effector of CRT in promoting cell migration ... DisGeNET Detail
Efficient induction of anti-tumor immune response in esophageal squamous cell carcinoma via dendriti... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
To accurately analyze the association between the histological types and molecular features of each ... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
CALR mutations were not found in PV or APMF. DisGeNET Detail
NA DisGeNET Detail
Most isolates had scpA, ska, saga, and slo genes, whereas speC, speG, speH, speI, speK, smez, and ss... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
We analysed CSF3R exons 14 and 17, and CALR exon 9, using direct sequencing in samples of paediatric... DisGeNET Detail
NA DisGeNET Detail
With the discoveries of underlying mutations in JAK2, MPL, and, most recently, calreticulin (CALR), ... DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
NA DisGeNET Detail
CALR mutations were present in 44% of ET (15/34), 14% of persistent thrombocytosis suggestive of MPN... DisGeNET Detail
NA DisGeNET Detail
Calreticulin promotes migration and invasion of esophageal cancer cells by upregulating neuropilin-1... DisGeNET Detail
NA DisGeNET Detail
In addition to immunogenicity and tumorigenesis, interactions between calreticulin and integrins hav... DisGeNET Detail
JAK2/MPL wild-type, CALR mutated hypercellular ET associated with PMGM is featured by dense clustere... DisGeNET Detail
NA DisGeNET Detail
Molecular profiling must include the analysis of JAK2 (looking for the V617F point-mutation in PV an... DisGeNET Detail
Patients with JAK2 V617F-positive MPN have a heterogeneous histology while CALR-positive ET is assoc... DisGeNET Detail
Patients with JAK2 V617F-positive MPN have a heterogeneous histology while CALR-positive ET is assoc... DisGeNET Detail
Frequency and allele burden of CALR mutations in Chinese with essential thrombocythemia and primary ... DisGeNET Detail
Calreticulin mutations (CALR(MUT)) are found in a significant proportion of patients with essential ... DisGeNET Detail
The classical Philadelphia chromosome-negative myeloproliferative neoplasms (MPN), which include ess... DisGeNET Detail
The classical Philadelphia chromosome-negative myeloproliferative neoplasms (MPN), which include ess... DisGeNET Detail
Frequency and allele burden of CALR mutations in Chinese with essential thrombocythemia and primary ... DisGeNET Detail
NA DisGeNET Detail
Molecular profiling must include the analysis of JAK2 (looking for the V617F point-mutation in PV an... DisGeNET Detail
The recent discovery of mutations within the CALR gene in up to 80% of JAK2 V617F-negative ET and PM... DisGeNET Detail
NA DisGeNET Detail
In the current study, mutations of JAK2 V617F, JAK2 exon 12, MPL exon 10, and CALR exon 9 were analy... DisGeNET Detail
This study revealed that CALR mutant essential thrombocythemia is associated with younger age, highe... DisGeNET Detail
This study revealed that CALR mutant essential thrombocythemia is associated with younger age, highe... DisGeNET Detail
Four main molecular types of clonal MPN can be distinguished: JAK2(V617F)-positive ET and PV; JAK2 w... DisGeNET Detail
JAK2/MPL wild-type, CALR mutated hypercellular ET associated with PMGM is featured by dense clustere... DisGeNET Detail
CRT and NRP1 coexpression was significantly associated with lymph node metastasis (P = 0.025). DisGeNET Detail
Sessile serrated adenomas/polyps (SSA/Ps) are a putative precursor of colon cancer with microsatelli... DisGeNET Detail
Knockdown CRT in gastric cancer cells was found to effectively reduce growth ability and metastasis ... DisGeNET Detail
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CALR mutations were present in 44% of ET (15/34), 14% of persistent thrombocytosis suggestive of MPN... DisGeNET Detail
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With regard to the histological type, the IGF2 DMR0 methylation levels of SSAs (mean ± SD, 73.1 ± 12... DisGeNET Detail
Then we summarize the clinicopathological features, classification and molecular profiles of the two... DisGeNET Detail
The SSA/Ps are more common and are more likely to be flat than TSAs. DisGeNET Detail
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Calreticulin: a new horizon for the testing and treatment of myeloproliferative neoplasms. DisGeNET Detail
Distinct clinical characteristics of myeloproliferative neoplasms with calreticulin mutations. DisGeNET Detail
The mutation profile of JAK2 and CALR in Chinese Han patients with Philadelphia chromosome-negative ... DisGeNET Detail
CALR mutations were present in 44% of ET (15/34), 14% of persistent thrombocytosis suggestive of MPN... DisGeNET Detail
Myeloproliferative neoplasms (MPNs) are stem cell-derived clonal myeloid malignancies characterized ... DisGeNET Detail
Frequency and molecular characteristics of calreticulin gene (CALR) mutations in patients with JAK2 ... DisGeNET Detail
Calreticulin mutations in myeloproliferative neoplasms and new methodology for their detection and m... DisGeNET Detail
The JAK2 46/1 haplotype does not predispose to CALR-mutated myeloproliferative neoplasms. DisGeNET Detail
Evaluation of methods to detect CALR mutations in myeloproliferative neoplasms. DisGeNET Detail
The mutation profile of JAK2, MPL and CALR in Mexican patients with Philadelphia chromosome-negative... DisGeNET Detail
In this chapter, we detail the genomic alterations that underlie MPNs, with a focus on the recent di... DisGeNET Detail
The prognostic significance of CALR mutations likely differs among the MPN subtypes. DisGeNET Detail
The true frequency of the JAK2 46/1 haplotype in patients of myeloproliferative neoplasms (MPN) with... DisGeNET Detail
The combined genetic tests of JAK2 V617F, JAK2 exon 12, MPL exon 10, and CALR exon 9 help improve th... DisGeNET Detail
ATG2B and GSKIP cooperate with acquired JAK2, MPL and CALR mutations during MPN development. DisGeNET Detail
Fourteen samples from 10 patients with JAK2 and MPL wild-type myeloproliferative neoplasms were posi... DisGeNET Detail
Clinical validation of a multipurpose assay for detection and genotyping of CALR mutations in myelop... DisGeNET Detail
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To accurately analyze the association between the histological types and molecular features of each ... DisGeNET Detail
Lupus-like manifestations consisted of pericarditis, pleuritis, and positive antinuclear and anti-SS... DisGeNET Detail
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To accurately analyze the association between the histological types and molecular features of each ... DisGeNET Detail
Then we summarize the clinicopathological features, classification and molecular profiles of the two... DisGeNET Detail
B-RAF mutation and accumulated gene methylation in aberrant crypt foci (ACF), sessile serrated adeno... DisGeNET Detail
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We analysed CSF3R exons 14 and 17, and CALR exon 9, using direct sequencing in samples of paediatric... DisGeNET Detail
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Serum calreticulin is a negative biomarker in patients with Alzheimer's disease. DisGeNET Detail
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Patients with CALR mutation had a lower risk of developing anemia, thrombocytopenia, and marked leuk... DisGeNET Detail
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Patients with CALR-mutated ET more frequently progressed to the accelerated or blast phases compared... DisGeNET Detail
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Sessile serrated adenomas/polyps (SSA/Ps) are a putative precursor of colon cancer with microsatelli... DisGeNET Detail
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Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs386626619 dbSNP
Genome
hg19
Position
chr19:13,049,423-13,055,303
Variant Type
snv
Variant (CIViC) (CIViC Variant)
MUTATION
Variant URL (CIViC Variant)
https://civic.genome.wustl.edu/links/variants/2388
Genome browser