chr17:7676154:G>C Detail (hg38) (TP53)

Information

Genome

Assembly Position
hg19 chr17:7,579,472-7,579,472 View the variant detail on this assembly version.
hg38 chr17:7,676,154-7,676,154

HGVS

Type Transcript Protein
RefSeq NM_000546.5:c.215C>G NP_000537.3:p.Pro72Arg
NM_001126112.2:c.215C>G NP_001119584.1:p.Pro72Arg
NM_001276760.1:c.215C>G NP_001263689.1:p.Pro72Arg
Summary

MGeND

Clinical significance Uncertain significance
Variant entry 1
GWAS entry
Disease area statistics Show details

Frequency

JP HGVD:0.652
ToMMo:0.645
NCBN:[No Data.]
NCBN(Hondo):[No Data.]
NCBN(Ryukyu):[No Data.]
East asia ExAC:0.589

Prediction

ClinVar

Clinical Significance Benign
Review star
Show details
Links
Type Database ID Link
Gene MIM 191170 OMIM
HGNC 11998 HGNC
Ensembl ENSG00000141510 Ensembl
NCBI NCBI
Gene Cards Gene Cards
OncoKB OncoKB
Type Database ID Link
Variant TogoVar tgv56957723 TogoVar
COSMIC COSM250061 COSMIC
MONDO
Disease area statistics
MGeND
Clinical significance Last evaluated Condition Origin Submission ID Submitter Institute Citation Comment Image
Uncertain significance li-fraumeni syndrome germline MGS000001
(TMGS000178) 		Kenjiro Kosaki Keio University
ClinVar
Clinical significance Last evaluated Review status Condition Origin Links
Benign 2009-10-01 no assertion criteria provided CODON 72 POLYMORPHISM unknown Detail
Benign 2023-11-30 criteria provided, multiple submitters, no conflicts not provided germline Detail
Benign 2016-04-05 criteria provided, multiple submitters, no conflicts not specified germline unknown Detail
Benign 2022-06-18 criteria provided, multiple submitters, no conflicts Hereditary cancer-predisposing syndrome germline Detail
Benign 2022-06-18 criteria provided, multiple submitters, no conflicts Li-Fraumeni syndrome 1 germline unknown Detail
Benign 2024-02-05 criteria provided, multiple submitters, no conflicts Li-Fraumeni syndrome germline Detail
Pathogenic 2019-04-30 no assertion criteria provided Lip and oral cavity carcinoma somatic Detail
Benign 2022-04-19 criteria provided, multiple submitters, no conflicts hereditary breast ovarian cancer syndrome germline Detail
Benign 2021-12-20 criteria provided, single submitter Bone marrow failure syndrome 5,hepatocellular carcinoma,bone osteosarcoma,Familial cancer of breast,Nasopharyngeal carcinoma,Li-Fraumeni syndrome 1,Carcinoma of pancreas,Glioma susceptibility 1,choroid plexus papilloma,colorectal cancer,Adrenocortical carcinoma, hereditary,Basal cell carcinoma, susceptibility to, 7 unknown Detail
Benign 2021-12-20 criteria provided, single submitter Bone marrow failure syndrome 5,hepatocellular carcinoma,bone osteosarcoma,Familial cancer of breast,Nasopharyngeal carcinoma,Li-Fraumeni syndrome 1,Carcinoma of pancreas,Glioma susceptibility 1,choroid plexus papilloma,colorectal cancer,Adrenocortical carcinoma, hereditary,Basal cell carcinoma, susceptibility to, 7 unknown Detail
Benign 2021-12-20 criteria provided, single submitter Bone marrow failure syndrome 5,hepatocellular carcinoma,bone osteosarcoma,Familial cancer of breast,Nasopharyngeal carcinoma,Li-Fraumeni syndrome 1,Carcinoma of pancreas,Glioma susceptibility 1,choroid plexus papilloma,colorectal cancer,Adrenocortical carcinoma, hereditary,Basal cell carcinoma, susceptibility to, 7 unknown Detail
Benign 2021-12-20 criteria provided, single submitter Bone marrow failure syndrome 5,hepatocellular carcinoma,bone osteosarcoma,Familial cancer of breast,Nasopharyngeal carcinoma,Li-Fraumeni syndrome 1,Carcinoma of pancreas,Glioma susceptibility 1,choroid plexus papilloma,colorectal cancer,Adrenocortical carcinoma, hereditary,Basal cell carcinoma, susceptibility to, 7 unknown Detail
Benign 2021-12-20 criteria provided, single submitter Bone marrow failure syndrome 5,hepatocellular carcinoma,bone osteosarcoma,Familial cancer of breast,Nasopharyngeal carcinoma,Li-Fraumeni syndrome 1,Carcinoma of pancreas,Glioma susceptibility 1,choroid plexus papilloma,colorectal cancer,Adrenocortical carcinoma, hereditary,Basal cell carcinoma, susceptibility to, 7 unknown Detail
Benign 2021-12-20 criteria provided, single submitter Bone marrow failure syndrome 5,hepatocellular carcinoma,bone osteosarcoma,Familial cancer of breast,Nasopharyngeal carcinoma,Li-Fraumeni syndrome 1,Carcinoma of pancreas,Glioma susceptibility 1,choroid plexus papilloma,colorectal cancer,Adrenocortical carcinoma, hereditary,Basal cell carcinoma, susceptibility to, 7 unknown Detail
Benign 2021-12-20 criteria provided, single submitter Bone marrow failure syndrome 5,hepatocellular carcinoma,bone osteosarcoma,Familial cancer of breast,Nasopharyngeal carcinoma,Li-Fraumeni syndrome 1,Carcinoma of pancreas,Glioma susceptibility 1,choroid plexus papilloma,colorectal cancer,Adrenocortical carcinoma, hereditary,Basal cell carcinoma, susceptibility to, 7 unknown Detail
Benign 2021-12-20 criteria provided, single submitter Bone marrow failure syndrome 5,hepatocellular carcinoma,bone osteosarcoma,Familial cancer of breast,Nasopharyngeal carcinoma,Li-Fraumeni syndrome 1,Carcinoma of pancreas,Glioma susceptibility 1,choroid plexus papilloma,colorectal cancer,Adrenocortical carcinoma, hereditary,Basal cell carcinoma, susceptibility to, 7 unknown Detail
Benign 2021-12-20 criteria provided, single submitter Bone marrow failure syndrome 5,hepatocellular carcinoma,bone osteosarcoma,Familial cancer of breast,Nasopharyngeal carcinoma,Li-Fraumeni syndrome 1,Carcinoma of pancreas,Glioma susceptibility 1,choroid plexus papilloma,colorectal cancer,Adrenocortical carcinoma, hereditary,Basal cell carcinoma, susceptibility to, 7 unknown Detail
Benign 2021-12-20 criteria provided, single submitter Bone marrow failure syndrome 5,hepatocellular carcinoma,bone osteosarcoma,Familial cancer of breast,Nasopharyngeal carcinoma,Li-Fraumeni syndrome 1,Carcinoma of pancreas,Glioma susceptibility 1,choroid plexus papilloma,colorectal cancer,Adrenocortical carcinoma, hereditary,Basal cell carcinoma, susceptibility to, 7 unknown Detail
Benign 2021-12-20 criteria provided, single submitter Bone marrow failure syndrome 5,hepatocellular carcinoma,bone osteosarcoma,Familial cancer of breast,Nasopharyngeal carcinoma,Li-Fraumeni syndrome 1,Carcinoma of pancreas,Glioma susceptibility 1,choroid plexus papilloma,colorectal cancer,Adrenocortical carcinoma, hereditary,Basal cell carcinoma, susceptibility to, 7 unknown Detail
Benign 2021-12-20 criteria provided, single submitter Bone marrow failure syndrome 5,hepatocellular carcinoma,bone osteosarcoma,Familial cancer of breast,Nasopharyngeal carcinoma,Li-Fraumeni syndrome 1,Carcinoma of pancreas,Glioma susceptibility 1,choroid plexus papilloma,colorectal cancer,Adrenocortical carcinoma, hereditary,Basal cell carcinoma, susceptibility to, 7 unknown Detail
Benign no assertion criteria provided acute myeloid leukemia somatic Detail
CIViC
Disease Drug EL ET ED CS VO TR Pubmed Links
breast cancer B Predisposing Does Not Support Positive Common Germline 4 17909070 Detail
lung carcinoma B Prognostic Does Not Support Poor Outcome Common Germline 3 12840112 Detail
cervical cancer B Prognostic Does Not Support Poor Outcome Common Germline 2 11535556 Detail
DisGeNET
Score Disease name Description Source Pubmed Links
<0.001 Carcinoma of lung We therefore investigated the combined effects of polymorphisms in TP53 (Arg72Pr... BeFree 17059853 Detail
0.013 colorectal carcinoma Association between XRCC1 ARG399GLN and P53 ARG72PRO polymorphisms and the risk ... BeFree 21971103 Detail
0.009 gallbladder carcinoma We therefore tested associations between CYP1A1 T3801C, CYP1A1 Ile462Val, GSTM1d... BeFree 18990008 Detail
0.033 breast carcinoma Pairwise analysis showed that combinations of the ERalpha G allele with the homo... BeFree 18820009 Detail
0.019 breast carcinoma A case (n=250)-control (n=500) study was undertaken to investigate the role of S... BeFree 18058229 Detail
0.056 Malignant tumor of cervix The Arg variant of p53 Arg72Pro is associated with progression of SIL to cervica... BeFree 23065429 Detail
0.010 HIV Infections To investigate the associations of TP53 R72P and MDM2 T309G SNPs with HPV infect... BeFree 24586820 Detail
0.085 colorectal carcinoma The p53 R72P genotype was identified by polymerase chain reaction-restriction fr... BeFree 18988302 Detail
0.031 esophageal carcinoma This study aimed to evaluate the prognostic significance of two functional singl... BeFree 19383811 Detail
0.062 colorectal cancer Association between XRCC1 ARG399GLN and P53 ARG72PRO polymorphisms and the risk ... BeFree 21971103 Detail
0.240 Malignant neoplasm of breast The TP53 gene polymorphisms, Arg72Pro and PIN3 (+16 bp), can have prognostic and... BeFree 21365326 Detail
0.009 Keloid Meta-analysis demonstrates association between Arg72Pro polymorphism in the P53 ... BeFree 22843046 Detail
0.002 Non-small cell lung carcinoma This study investigated whether the functional polymorphisms in P53 pathway gene... BeFree 21841506 Detail
0.084 Malignant neoplasm of stomach Pro variant of TP53 Arg72Pro contributes to gastric cancer risk in Asians: evide... BeFree 22631671 Detail
0.080 breast carcinoma Individual and combined effects of MDM2 SNP309 and TP53 Arg72Pro on breast cance... BeFree 22729912 Detail
0.080 Carcinoma of lung Lack of evidence that p53 Arg72Pro influences lung cancer prognosis: an analysis... BeFree 17400332 Detail
0.034 endometriosis Meta-analysis of association between the TP53 Arg72Pro polymorphism and risk of ... BeFree 25819169 Detail
<0.001 neutropenia MDM2 SNP309 and TP53 R72P are significantly associated with severe neutropenia a... BeFree 21706156 Detail
0.012 osteosarcoma Effect of TP53 Arg72Pro and MDM2 SNP309 polymorphisms on the risk of high-grade ... BeFree 19451596 Detail
0.015 Solid tumour Among the natural sequence variants of TP53, rs1042522 (R72P) modifies the risk ... BeFree 19837266 Detail
0.150 renal cell carcinoma Polymorphisms of p53 Arg(72)Pro and p21 Ser(31)Arg did not show significant asso... BeFree 17634539 Detail
0.006 Diabetes Mellitus, Non-Insulin-Dependent Using SNP- and gene-based analysis methods, we replicated previously reported SN... BeFree 18678618 Detail
0.014 melanoma Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105... BeFree 23568549 Detail
<0.001 Experimental Organism Basal Cell Carcinoma We evaluated the effect of MDM2 SNP309 and its interaction with the p53 Arg72Pro... BeFree 18814047 Detail
0.001 Cutaneous Melanoma Investigation of the effect of MDM2 SNP309 and TP53 Arg72Pro polymorphisms on th... BeFree 22336942 Detail
0.003 Nasopharyngeal carcinoma The results suggested that the Arg399Gln polymorphism of XRCC1 gene, the 1G/2G p... BeFree 25481674 Detail
0.007 Adenocarcinoma of large intestine The current case-control study was conducted in order to elucidate any possible ... BeFree 18507052 Detail
0.080 breast carcinoma These findings indicate that the SNPs in P53BP1 and p53 jointly contribute to br... BeFree 16314399 Detail
0.080 breast carcinoma Involvement of p53 R72P polymorphism in the association of MDM2-SNP309 with brea... BeFree 21479369 Detail
0.056 Malignant tumor of cervix We failed to confirm earlier reports of increased cervical cancer susceptibility... BeFree 12142377 Detail
<0.001 Xeroderma Pigmentosum, Complementation Group D Specifically, 2 polymorphisms-an arginine-to-glutamine substitution at codon 399... BeFree 23096768 Detail
<0.001 Cutaneous Melanoma Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105... BeFree 23568549 Detail
0.017 uterine corpus cancer Association of p73 G4C14-to-A4T14 polymorphism at exon 2 and p53 Arg72Pro polymo... BeFree 15723718 Detail
0.021 breast carcinoma Involvement of p53 R72P polymorphism in the association of MDM2-SNP309 with brea... BeFree 21479369 Detail
0.157 pancreatic carcinoma This meta-analysis suggests that Pro allele in P53 Arg72Pro is significantly ass... BeFree 21376265 Detail
0.002 Lip and oral cavity carcinoma To explore the role of polymorphisms of p53-related genes in etiology of oral ca... BeFree 22052649 Detail
0.085 colorectal carcinoma Association between XRCC1 ARG399GLN and P53 ARG72PRO polymorphisms and the risk ... BeFree 21971103 Detail
<0.001 Malignant tumor of cervix We genotyped 4 single nucleotide polymorphisms (SNPs) with amino acid changes, T... BeFree 19482343 Detail
<0.001 Malignant neoplasm of endometrium We searched multiple databases (through March 8, 2011) for studies investigating... BeFree 23729685 Detail
0.080 breast carcinoma The significance of MDM2 SNP309 and p53 Arg72Pro in young women with breast canc... BeFree 19639206 Detail
0.011 Malignant neoplasm of breast Association of p53 codon Arg72Pro and p73 G4C14-to-A4T14 at exon 2 genetic polym... BeFree 14634508 Detail
0.059 Malignant neoplasm of breast We pooled data from four breast cancer cohorts within the Breast Cancer Associat... BeFree 20021639 Detail
0.012 melanoma Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105... BeFree 23568549 Detail
0.019 Thyroid carcinoma Association between p53 Arg72Pro polymorphism and thyroid cancer risk: a meta-an... BeFree 24037912 Detail
0.059 Malignant neoplasm of breast Involvement of p53 R72P polymorphism in the association of MDM2-SNP309 with brea... BeFree 21479369 Detail
0.017 uterine corpus cancer Genotype misclassification in genetic association studies of the rs1042522 TP53 ... BeFree 23729685 Detail
0.004 Malignant neoplasm of endometrium Association of MDM2 SNP309 and TP53 Arg72Pro polymorphisms with risk of endometr... BeFree 23624782 Detail
0.014 Carcinogenesis In case-only analysis, the homozygous p73 G4C14-to-A4T14 variant of p73 genotype... BeFree 21976716 Detail
0.066 Malignant neoplasm of esophagus When all 11 studies were pooled into the analysis, an increased esophageal cance... BeFree 20389250 Detail
0.069 prostate carcinoma Detection of human papillomavirus (HPV) DNA prevalence and p53 codon 72 (Arg72Pr... BeFree 25213701 Detail
0.002 Non-small cell lung carcinoma We evaluated seven single-nucleotide polymorphisms of six genes CDA Lys27Gln (A/... BeFree 22052224 Detail
<0.001 Hereditary Nonpolyposis Colorectal Cancer The additive effect of p53 Arg72Pro and RNASEL Arg462Gln genotypes on age of dis... BeFree 17224235 Detail
0.001 Adenocarcinoma Of Esophagus Association of MDM2 T309G and p53 Arg72Pro polymorphisms and gastroesophageal re... BeFree 23735059 Detail
0.085 colorectal carcinoma Age of diagnosis of colorectal cancer in HNPCC patients is more complex than tha... BeFree 16353134 Detail
0.099 Malignant neoplasm of breast Role of GSTM1 (Null/Present), GSTP1 (Ile105Val) and P53 (Arg72Pro) genetic polym... BeFree 17696741 Detail
<0.001 cervical cancer squamous cell The p53 Arg72Pro polymorphism, human papillomavirus, and invasive squamous cell ... BeFree 10698487 Detail
0.034 endometriosis TP53 Arg72Pro polymorphism (rs1042522) and risk of endometriosis among Asian and... BeFree 25889195 Detail
0.329 Glioma Prognostic value of TP53 Pro47Ser and Arg72Pro single nucleotide polymorphisms a... BeFree 18393224 Detail
0.163 lymphoma Polymorphisms of p53 Arg72Pro, p73 G4C14-to-A4T14 at exon 2 and p21 Ser31Arg and... BeFree 15291355 Detail
0.400 sarcoma The functional MDM2 T309G genetic variant but not P53 Arg72Pro polymorphism is a... BeFree 22205265 Detail
0.080 Carcinoma of lung Cox regression analysis showed p53 Arg72Pro heterozygous genotype was overall an... BeFree 18181044 Detail
0.309 Esophageal Neoplasms This study aimed to evaluate the prognostic significance of two functional singl... BeFree 19383811 Detail
0.056 Malignant tumor of cervix The p53 R72P polymorphism does not influence cervical cancer development in a Po... BeFree 18205229 Detail
<0.001 gastroesophageal reflux disease Association of MDM2 T309G and p53 Arg72Pro polymorphisms and gastroesophageal re... BeFree 23735059 Detail
0.007 Sporadic Breast Carcinoma We here studied the association of rs1219648 in FGFR2 and rs1042522 in TP53 and ... BeFree 25292094 Detail
0.006 Cutaneous Melanoma MDM2 SNP309 and p53 Arg72Pro in cutaneous melanoma: association between SNP309 G... BeFree 20535124 Detail
<0.001 Premenopausal breast cancer Association of rs1219648 in FGFR2 and rs1042522 in TP53 with premenopausal breas... BeFree 25292094 Detail
0.080 breast carcinoma Functional MDM4 rs4245739 genetic variant, alone and in combination with P53 Arg... BeFree 23793604 Detail
0.240 Malignant neoplasm of breast Association of the germline TP53 R72P and MDM2 SNP309 variants with breast cance... BeFree 21667122 Detail
0.219 Non-small cell lung carcinoma Frequency of TP53 mutations in relation to Arg72Pro genotypes in non small cell ... BeFree 17932356 Detail
0.080 Carcinoma of lung Four of the variants were found to be weakly associated with lung cancer risk wi... BeFree 18990748 Detail
0.025 Malignant neoplasm of skin We evaluated the effect of MDM2 SNP309 and its interaction with the p53 Arg72Pro... BeFree 18814047 Detail
0.006 Diabetes Mellitus, Non-Insulin-Dependent We demonstrated that the polymorphism in TP53 (rs1042522) was associated with ty... BeFree 21146886 Detail
0.002 Malignant neoplasm of gallbladder These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and t... BeFree 17531965 Detail
0.160 Malignant neoplasm of lung TP53 Arg72Pro polymorphism and lung cancer risk: a meta-analysis. BeFree 19623649 Detail
0.160 Malignant neoplasm of lung Therefore, we hypothesized that the genetic variants in these three genes influe... BeFree 16912209 Detail
<0.001 Prostate Cancer, Hereditary, 7 We did not observe any statistically significant association between the p53 Arg... BeFree 20855462 Detail
0.160 colorectal cancer TP53 Arg72Pro polymorphism and colorectal cancer risk: a systematic review and m... BeFree 20615891 Detail
0.151 schizophrenia In order to examine the role of the p53 gene for the pathogenesis of schizophren... BeFree 11814547 Detail
0.025 Malignant neoplasm of skin TP53 Arg72Pro polymorphism and skin cancer risk: a meta-analysis. BeFree 20861852 Detail
<0.001 gastroesophageal reflux disease Association of MDM2 T309G and p53 Arg72Pro polymorphisms and gastroesophageal re... BeFree 23735059 Detail
0.240 Malignant neoplasm of breast TGFbeta1 (Leu10Pro), p53 (Arg72Pro) can predict for increased risk for breast ca... BeFree 18058229 Detail
0.511 liver carcinoma Homozygosity for Pro of p53 Arg72Pro as a potential risk factor for hepatocellul... BeFree 15633234 Detail
0.003 Cerebrovascular accident The human Tp53 Arg72Pro polymorphism explains different functional prognosis in ... BeFree 21357744 Detail
0.240 Malignant neoplasm of breast The significance of MDM2 SNP309 and p53 Arg72Pro in young women with breast canc... BeFree 19639206 Detail
0.213 cervix carcinoma The Arg variant of p53 Arg72Pro is associated with progression of SIL to cervica... BeFree 23065429 Detail
0.085 ovarian carcinoma We conducted a case-control study in order to investigate the association of RAD... BeFree 24114315 Detail
0.240 Malignant neoplasm of breast The p53 Arg72Pro and MDM2 -309 polymorphisms and risk of breast cancer in the nu... BeFree 17387621 Detail
0.440 squamous cell carcinoma In a large prospective cohort, p53 Arg72Pro Pro/Pro was associated with a 2-fold... BeFree 19383811 Detail
0.006 rheumatoid arthritis Association of rheumatoid arthritis with Mdm2 SNP309 and genetic evidence for an... BeFree 19772793 Detail
0.007 Malignant neoplasm of gallbladder We therefore tested associations between CYP1A1 T3801C, CYP1A1 Ile462Val, GSTM1d... BeFree 18990008 Detail
0.001 Premenopausal breast cancer Association of rs1219648 in FGFR2 and rs1042522 in TP53 with premenopausal breas... BeFree 25292094 Detail
0.001 cervix carcinoma Genetic polymorphisms of p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro and the r... BeFree 15036661 Detail
0.005 breast carcinoma Association of p53 codon Arg72Pro and p73 G4C14-to-A4T14 at exon 2 genetic polym... BeFree 14634508 Detail
0.134 Non-small cell lung carcinoma We evaluated seven single-nucleotide polymorphisms of six genes CDA Lys27Gln (A/... BeFree 22052224 Detail
0.005 Undifferentiated carcinoma Recent studies have shown a significant correlation between the presence of p53 ... BeFree 12684657 Detail
0.160 colorectal cancer We have previously reported that the common, functionally different variants Arg... BeFree 17224235 Detail
0.080 breast carcinoma Role of GSTM1 (Null/Present), GSTP1 (Ile105Val) and P53 (Arg72Pro) genetic polym... BeFree 17696741 Detail
0.006 breast carcinoma Association of p53 codon Arg72Pro and p73 G4C14-to-A4T14 at exon 2 genetic polym... BeFree 14634508 Detail
0.080 breast carcinoma Association of the germline TP53 R72P and MDM2 SNP309 variants with breast cance... BeFree 21667122 Detail
0.160 Malignant neoplasm of lung Cox regression analysis showed p53 Arg72Pro heterozygous genotype was overall an... BeFree 18181044 Detail
<0.001 Febrile Neutropenia MDM2 SNP309 and TP53 R72P associated with severe and febrile neutropenia in brea... BeFree 21706156 Detail
0.010 Preleukemia The relationship of TP53 R72P polymorphism to disease outcome and TP53 mutation ... BeFree 25768405 Detail
0.213 cervix carcinoma Genetic polymorphisms of p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro and the r... BeFree 15036661 Detail
0.160 colorectal cancer TP53 Pro47Ser and Arg72Pro polymorphisms and colorectal cancer predisposition in... BeFree 20449797 Detail
0.007 Breast Cancer, Familial The G13964C intronic variant was significantly associated with familial breast c... BeFree 20233677 Detail
0.005 Hereditary Nonpolyposis Colorectal Cancer We have previously reported that the common, functionally different variants Arg... BeFree 17224235 Detail
0.440 squamous cell carcinoma An SNP, Arg72Pro, of the TP53 gene encoding a DNA damage response protein showed... BeFree 15609317 Detail
<0.001 Malignant neoplasm of mouth To explore the role of polymorphisms of p53-related genes in etiology of oral ca... BeFree 22052649 Detail
0.213 cervix carcinoma The p53 R72P polymorphism does not influence cervical cancer development in a Po... BeFree 18205229 Detail
0.240 Malignant neoplasm of breast Combining the two 'candidate' SNPs (P187S and R72P) revealed an increased risk f... BeFree 15138483 Detail
0.001 Premenopausal breast cancer The results indicate protective associations of p53 Arg72Pro heterozygous varian... BeFree 17719241 Detail
0.025 Malignant neoplasm of skin Arg72Pro polymorphism of TP53 gene and the risk of skin cancer: a meta-analysis. BeFree 24260330 Detail
0.214 Malignant neoplasm of lung Four of the variants were found to be weakly associated with lung cancer risk wi... BeFree 18990748 Detail
0.007 Sporadic Breast Carcinoma The study provides evidence of the association of the TP53 gene polymorphisms Ar... BeFree 21061796 Detail
0.133 Lymphoma, Non-Hodgkin The functional TP53 rs1042522 and MDM4 rs4245739 genetic variants contribute to ... BeFree 25203442 Detail
0.001 Hereditary Nonpolyposis Colorectal Cancer Recently a polymorphism at codon 72 (R72P) in the tumour suppressor gene TP53 ha... BeFree 16353134 Detail
0.039 Cervical Intraepithelial Neoplasia [TP53 polymorphisms may affect both CIN3+ and persistent HPV infection. However,... GAD 19423538 Detail
0.029 Malignant neoplasm of mouth Polymorphism of the p53 codon 72 Arg/Pro and the risk of HPV type 16/18-associat... BeFree 14577584 Detail
<0.001 Multiple tumors Several studies have examined the prognostic value of the TP53 Arg72Pro polymorp... BeFree 23423487 Detail
0.021 breast carcinoma Association of the germline TP53 R72P and MDM2 SNP309 variants with breast cance... BeFree 21667122 Detail
0.005 Malignant neoplasm of breast Association of p53 codon Arg72Pro and p73 G4C14-to-A4T14 at exon 2 genetic polym... BeFree 14634508 Detail
0.002 Squamous intraepithelial lesion The Arg variant of p53 Arg72Pro is associated with progression of SIL to cervica... BeFree 23065429 Detail
0.004 lymphoma Polymorphisms of p53 Arg72Pro, p73 G4C14-to-A4T14 at exon 2 and p21 Ser31Arg and... BeFree 15291355 Detail
0.010 Blast Phase Two functional single nucleotide polymorphisms (SNPs), p53 R72P and MDM2 SNP309,... BeFree 23818300 Detail
0.044 Malignant neoplasm of lung Four of the variants were found to be weakly associated with lung cancer risk wi... BeFree 18990748 Detail
<0.001 uterine corpus cancer Association of p73 G4C14-to-A4T14 polymorphism at exon 2 and p53 Arg72Pro polymo... BeFree 15723718 Detail
<0.001 Amyotrophic Lateral Sclerosis, Sporadic TP53 Arg72Pro polymorphism in Turkish patients with sporadic amyotrophic lateral... BeFree 21741128 Detail
0.031 esophageal carcinoma Association of p53 Arg72Pro polymorphism with esophageal cancer: a meta-analysis... BeFree 23844939 Detail
0.123 Malignant neoplasm of ovary In conclusion SNPs in WRAP53 (rs2287497 and rs2287498) have stronger association... BeFree 23192612 Detail
0.069 prostate carcinoma Although we did not find a significant relationship between the frequency of the... BeFree 17785557 Detail
<0.001 Malignant neoplasm of lung We therefore investigated the combined effects of polymorphisms in TP53 (Arg72Pr... BeFree 17059853 Detail
0.001 Sporadic Breast Carcinoma We here studied the association of rs1219648 in FGFR2 and rs1042522 in TP53 and ... BeFree 25292094 Detail
0.017 Malignant neoplasm of endometrium Association of MDM2 SNP309 and TP53 Arg72Pro polymorphisms with risk of endometr... BeFree 23624782 Detail
0.440 squamous cell carcinoma In this study, we analyzed the association of TP53 Pro72Arg polymorphism with sq... BeFree 25436609 Detail
0.085 colorectal carcinoma We aimed to investigate the association between miR-34b/c rs4938723 and TP53 Arg... BeFree 23183747 Detail
0.121 endometrial carcinoma Association of MDM2 SNP309 and TP53 Arg72Pro polymorphisms with risk of endometr... BeFree 23624782 Detail
0.240 Malignant neoplasm of breast Epistatic interaction of Arg72Pro TP53 and -710 C/T VEGFR1 polymorphisms in brea... BeFree 23716179 Detail
0.329 Glioma Quantitative assessment of the association between TP53 Arg72Pro polymorphism an... BeFree 24046089 Detail
0.132 Adenocarcinoma Of Esophagus Association of MDM2 T309G and p53 Arg72Pro polymorphisms and gastroesophageal re... BeFree 23735059 Detail
0.096 Malignant neoplasm of breast A case (n=250)-control (n=500) study was undertaken to investigate the role of S... BeFree 18058229 Detail
0.064 Carcinoma of bladder The role of TP53 PRO47SER and ARG72PRO single nucleotide polymorphisms in the su... BeFree 19523860 Detail
0.329 Glioma The effects of p53 Arg72Pro polymorphism on glioma susceptibility: a meta-analys... BeFree 24488625 Detail
0.309 Esophageal Neoplasms Among the five TP53 polymorphisms investigated, only p.R72P polymorphism may con... BeFree 25339039 Detail
0.006 ovarian carcinoma We conducted a case-control study in order to investigate the association of RAD... BeFree 24114315 Detail
0.309 Esophageal Neoplasms Association of p53 Arg72Pro polymorphism with esophageal cancer: a meta-analysis... BeFree 23844939 Detail
0.080 breast carcinoma The TP53 gene polymorphisms, Arg72Pro and PIN3 (+16 bp), can have prognostic and... BeFree 21365326 Detail
0.003 Diabetes Mellitus, Non-Insulin-Dependent Studies of the association of Arg72Pro of tumor suppressor protein p53 with type... BeFree 21283750 Detail
0.039 Cervical Intraepithelial Neoplasia We performed a case-control association study to evaluate the association betwee... BeFree 24474455 Detail
0.080 breast carcinoma The p53 Arg72Pro and MDM2 -309 polymorphisms and risk of breast cancer in the nu... BeFree 17387621 Detail
0.085 colorectal carcinoma We have previously reported that the common, functionally different variants Arg... BeFree 17224235 Detail
0.017 Carcinogenesis In case-only analysis, the homozygous p73 G4C14-to-A4T14 variant of p73 genotype... BeFree 21976716 Detail
0.085 ovarian carcinoma In conclusion SNPs in WRAP53 (rs2287497 and rs2287498) have stronger association... BeFree 23192612 Detail
0.016 breast carcinoma A case (n=250)-control (n=500) study was undertaken to investigate the role of S... BeFree 18058229 Detail
0.160 Malignant neoplasm of lung Present report evaluated the association of polymorphism in exon 4 Arg72Pro (G&g... BeFree 23317414 Detail
0.030 squamous cell carcinoma In a large prospective cohort, p53 Arg72Pro Pro/Pro was associated with a 2-fold... BeFree 19383811 Detail
<0.001 Hereditary pancreatitis In conclusions, p53 Arg72Pro polymorphism is a potential marker of HP infection-... BeFree 24289637 Detail
<0.001 Cutaneous Melanoma Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105... BeFree 23568549 Detail
0.084 Malignant neoplasm of stomach This meta-analysis suggests that Pro allele in P53 Arg72Pro is significantly ass... BeFree 21376265 Detail
0.014 Carcinoma of lung Four of the variants were found to be weakly associated with lung cancer risk wi... BeFree 18990748 Detail
0.080 Carcinoma of lung Therefore, we hypothesized that the genetic variants in these three genes influe... BeFree 16912209 Detail
0.075 stomach carcinoma Association of p53 Arg72Pro polymorphism with gastric cancer: a meta-analysis. BeFree 22780299 Detail
0.039 Cervical Intraepithelial Neoplasia [TP53 genetic polymorphisms and environmental risk factors associated with cervi... GAD 20563922 Detail
0.056 Malignant tumor of cervix Genetic polymorphisms of p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro and the r... BeFree 15036661 Detail
0.006 endometrial carcinoma Association of MDM2 SNP309 and TP53 Arg72Pro polymorphisms with risk of endometr... BeFree 23624782 Detail
0.017 uterine corpus cancer TP53 Arg72Pro polymorphism and endometrial cancer risk: a meta-analysis. BeFree 20552298 Detail
0.007 lymphoma Polymorphisms of p53 Arg72Pro, p73 G4C14-to-A4T14 at exon 2 and p21 Ser31Arg and... BeFree 15291355 Detail
0.066 Malignant neoplasm of esophagus These results suggest that p53 Arg72Pro polymorphism, but not GSTP1 Ile105Val, m... BeFree 20827430 Detail
0.264 Bladder Neoplasm Several studies have investigated the association between TP53 Arg72Pro and an i... BeFree 19523860 Detail
0.030 squamous cell carcinoma We evaluated the effect of MDM2 SNP309 and its interaction with the p53 Arg72Pro... BeFree 18814047 Detail
0.240 Malignant neoplasm of breast Role of GSTM1 (Null/Present), GSTP1 (Ile105Val) and P53 (Arg72Pro) genetic polym... BeFree 17696741 Detail
0.075 stomach carcinoma This study provides evidence supporting the association of p53 SNP Arg72Pro with... BeFree 21443127 Detail
0.002 Malignant neoplasm of oropharynx Stratification analyses showed that a reduced risk associated with the -606CC ge... BeFree 20935061 Detail
<0.001 neutropenia MDM2 SNP309 and TP53 R72P are significantly associated with severe neutropenia a... BeFree 21706156 Detail
0.134 Li-Fraumeni syndrome Impact of the MDM2 SNP309 and p53 Arg72Pro polymorphism on age of tumour onset i... BeFree 16258005 Detail
0.017 Malignant neoplasm of endometrium Association of p73 G4C14-to-A4T14 polymorphism at exon 2 and p53 Arg72Pro polymo... BeFree 15723718 Detail
0.080 breast carcinoma An evaluation of the polymorphisms Ins16bp and Arg72Pro in p53 as breast cancer ... BeFree 18781154 Detail
0.240 Malignant neoplasm of breast Individual and combined effects of MDM2 SNP309 and TP53 Arg72Pro on breast cance... BeFree 22729912 Detail
0.064 Carcinoma of bladder Association of p53 Arg72Pro polymorphism with bladder cancer: a meta-analysis. BeFree 23073555 Detail
0.014 Experimental Organism Basal Cell Carcinoma We evaluated the effect of MDM2 SNP309 and its interaction with the p53 Arg72Pro... BeFree 18814047 Detail
0.121 Malignant neoplasm of urinary bladder Association of p53 Arg72Pro polymorphism with bladder cancer: a meta-analysis. BeFree 23073555 Detail
0.216 Malignant neoplasm of breast RAD51 135G&gt;C and TP53 Arg72Pro polymorphisms and susceptibility to breast can... BeFree 24114315 Detail
0.027 ulcerative colitis R72P polymorphism of TP53 in ulcerative colitis patients is associated with the ... BeFree 20309662 Detail
<0.001 Lymphoma, Non-Hodgkin The functional TP53 rs1042522 and MDM4 rs4245739 genetic variants contribute to ... BeFree 25203442 Detail
0.511 liver carcinoma Association between TP53 Arg72Pro polymorphism and hepatocellular carcinoma risk... BeFree 23167333 Detail
0.002 Multiple tumors Several studies have examined the prognostic value of the TP53 Arg72Pro polymorp... BeFree 23423487 Detail
0.005 diabetes mellitus The SNP rs4938723 and diabetes mellitus (DM) together were associated with an in... BeFree 24337371 Detail
0.085 ovarian carcinoma Meta-analysis shows significant association of the TP53 Arg72Pro with ovarian ca... BeFree 21952824 Detail
0.021 breast carcinoma Individual and combined effects of MDM2 SNP309 and TP53 Arg72Pro on breast cance... BeFree 22729912 Detail
0.012 Transitional cell carcinoma of bladder Clinical implications of the MDM2 SNP309 and p53 Arg72Pro polymorphisms in trans... BeFree 18575717 Detail
<0.001 Dissecting aneurysm of the thoracic aorta To evaluate the role of genetic P53 polymorphism in RP, we analyzed the P53 Arg7... BeFree 20729006 Detail
0.080 breast carcinoma Association of p53 codon Arg72Pro and p73 G4C14-to-A4T14 at exon 2 genetic polym... BeFree 14634508 Detail
0.005 Leukemia, Lymphocytic, Acute, L1 Genetic polymorphisms in the 3'UTR region of the CXCL12 (rs1801157) and TP53 cod... BeFree 23653000 Detail
<0.001 uterine corpus cancer We searched multiple databases (through March 8, 2011) for studies investigating... BeFree 23729685 Detail
0.018 Malignant neoplasm of ovary We conducted a case-control study in order to investigate the association of RAD... BeFree 24114315 Detail
0.156 Non-small cell lung carcinoma We evaluated seven single-nucleotide polymorphisms of six genes CDA Lys27Gln (A/... BeFree 22052224 Detail
0.017 Malignant neoplasm of endometrium TP53 Arg72Pro polymorphism and endometrial cancer risk: a meta-analysis. BeFree 20552298 Detail
0.029 Malignant neoplasm of mouth To explore the role of polymorphisms of p53-related genes in etiology of oral ca... BeFree 22052649 Detail
0.004 cervix carcinoma Genetic polymorphisms of p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro and the r... BeFree 15036661 Detail
0.309 Esophageal Neoplasms TP53 Arg72Pro polymorphism is associated with esophageal cancer risk: a meta-ana... BeFree 21448430 Detail
0.004 Glaucoma, Primary Open Angle Association between p53 codon 72 (Arg72Pro) polymorphism and primary open-angle ... BeFree 25605490 Detail
0.132 Malignant neoplasm of breast These findings indicate that the SNPs in P53BP1 and p53 jointly contribute to br... BeFree 16314399 Detail
0.001 Malignant tumor of cervix Genetic polymorphisms of p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro and the r... BeFree 15036661 Detail
0.001 hepatitis B Thus, MDM2 SNP 309 and p53 Arg72Pro are associated with the early development of... BeFree 18390844 Detail
<0.001 Febrile Neutropenia MDM2 SNP309 and TP53 R72P associated with severe and febrile neutropenia in brea... BeFree 21706156 Detail
0.080 breast carcinoma The results of present study indicated that among the five TP53 polymorphisms in... BeFree 25169539 Detail
0.017 Malignant neoplasm of endometrium Genotype misclassification in genetic association studies of the rs1042522 TP53 ... BeFree 23729685 Detail
0.003 hepatitis A Subgroup analyses by source of controls and hepatitis virus infection status fur... BeFree 23564481 Detail
0.088 Papillomavirus Infections [TP53 polymorphisms may affect both CIN3+ and persistent HPV infection. However,... GAD 19423538 Detail
0.240 Malignant neoplasm of breast The p53 R72P polymorphism has been suggested to play a role in many cancers, inc... BeFree 16033823 Detail
0.160 colorectal cancer Association between XRCC1 ARG399GLN and P53 ARG72PRO polymorphisms and the risk ... BeFree 21971103 Detail
0.031 esophageal carcinoma These results suggest that p53 Arg72Pro polymorphism, but not GSTP1 Ile105Val, m... BeFree 20827430 Detail
0.309 Esophageal Neoplasms When all 11 studies were pooled into the analysis, an increased esophageal cance... BeFree 20389250 Detail
0.085 colorectal carcinoma TP53 R72P and MDM2 SNP309 polymorphisms and colorectal cancer risk: the Fukuoka ... BeFree 21051533 Detail
0.014 glaucoma Rare WDR36 variants and the P53 p.R72P polymorphism behaved as moderate glaucoma... BeFree 21931130 Detail
0.213 cervix carcinoma We failed to confirm earlier reports of increased cervical cancer susceptibility... BeFree 12142377 Detail
0.230 Squamous cell carcinoma of esophagus Pro variant of TP53 Arg72Pro contributes to esophageal squamous cell carcinoma r... BeFree 20389250 Detail
0.004 Ichthyosis, X-Linked We investigated p53 codon 72 polymorphism (Arg72Pro) frequencies with respect to... BeFree 19065769 Detail
0.008 Malignant neoplasm of thyroid Association between p53 Arg72Pro polymorphism and thyroid cancer risk: a meta-an... BeFree 24037912 Detail
0.001 Salivary Gland Neoplasms TP53 single nucleotide polymorphism rs1042522 in salivary gland neoplasms. BeFree 24115240 Detail
0.099 Malignant neoplasm of breast A case (n=250)-control (n=500) study was undertaken to investigate the role of S... BeFree 18058229 Detail
0.160 Malignant neoplasm of lung Four of the variants were found to be weakly associated with lung cancer risk wi... BeFree 18990748 Detail
0.261 Nasopharyngeal carcinoma The results suggested that the Arg399Gln polymorphism of XRCC1 gene, the 1G/2G p... BeFree 25481674 Detail
0.019 breast carcinoma RAD51 135G&gt;C and TP53 Arg72Pro polymorphisms and susceptibility to breast can... BeFree 24114315 Detail
0.172 Squamous cell carcinoma of the head and neck Stratification analyses showed that a reduced risk associated with the -606CC ge... BeFree 20935061 Detail
0.064 Carcinoma of bladder Meta-analysis of association between TP53 Arg72Pro polymorphism and bladder canc... BeFree 20630574 Detail
0.080 Carcinogenesis The gene-gene interaction between TP53 Arg72Pro and MDM2 T309G may interact in c... BeFree 22744426 Detail
0.031 esophageal carcinoma When all 11 studies were pooled into the analysis, an increased esophageal cance... BeFree 20389250 Detail
0.010 Xeroderma Pigmentosum, Complementation Group D Specifically, 2 polymorphisms-an arginine-to-glutamine substitution at codon 399... BeFree 23096768 Detail
0.226 melanoma Investigation of the effect of MDM2 SNP309 and TP53 Arg72Pro polymorphisms on th... BeFree 22336942 Detail
0.080 breast carcinoma These findings indicate that the SNPs in P53BP1 and p53 jointly contribute to br... BeFree 16314399 Detail
0.080 breast carcinoma Combined effects of MDM2 SNP309 and TP53 R72P polymorphisms, and soy isoflavones... BeFree 21833626 Detail
0.056 Malignant tumor of cervix The results indicated that the polymorphism in TP53 (rs1042522) might be associa... BeFree 23534750 Detail
0.080 breast carcinoma Combining the two 'candidate' SNPs (P187S and R72P) revealed an increased risk f... BeFree 15138483 Detail
0.084 Malignant neoplasm of stomach Association of p53 Arg72Pro polymorphism with gastric cancer: a meta-analysis. BeFree 22780299 Detail
0.393 Diabetes Mellitus, Non-Insulin-Dependent Using SNP- and gene-based analysis methods, we replicated previously reported SN... BeFree 18678618 Detail
0.080 Carcinogenesis Polymorphism of p53 gene codon72 arginine (Arg)/proline (Pro) (rs1042522) may in... BeFree 24326769 Detail
0.019 Thyroid carcinoma Association between TP53 Arg72Pro polymorphism and thyroid carcinoma risk. BeFree 24375191 Detail
0.134 Li-Fraumeni syndrome Previous studies have highlighted the contribution of the common functional poly... BeFree 21814224 Detail
0.002 Nasopharyngeal carcinoma The results suggested that the Arg399Gln polymorphism of XRCC1 gene, the 1G/2G p... BeFree 25481674 Detail
0.160 colorectal cancer We aimed to investigate the association between miR-34b/c rs4938723 and TP53 Arg... BeFree 23183747 Detail
0.019 breast carcinoma Role of GSTM1 (Null/Present), GSTP1 (Ile105Val) and P53 (Arg72Pro) genetic polym... BeFree 17696741 Detail
0.219 Non-small cell lung carcinoma This study investigated whether the functional polymorphisms in P53 pathway gene... BeFree 21841506 Detail
0.005 breast carcinoma Epistatic interaction of Arg72Pro TP53 and -710 C/T VEGFR1 polymorphisms in brea... BeFree 23716179 Detail
0.001 Lymphoma, Large-Cell, Follicular Our findings provide evidence that the TP53 Arg72Pro is associated with an incre... BeFree 20734458 Detail
0.019 chronic lymphocytic leukemia Although the p53 R72P SNPs and MDM2 SNP309 did not associate with any of the par... BeFree 17981213 Detail
0.080 Carcinogenesis In case-only analysis, the homozygous p73 G4C14-to-A4T14 variant of p73 genotype... BeFree 21976716 Detail
0.002 mycosis fungoides Association of p53 Arg72Pro polymorphism and beta-catenin accumulation in mycosi... BeFree 17107393 Detail
0.160 Malignant neoplasm of lung The association between TP53 Arg72Pro polymorphism and lung cancer susceptibilit... BeFree 23595658 Detail
0.230 Squamous cell carcinoma of esophagus We used SSCP and DNA sequencing to assess and compare frequencies of R72P (TP53)... BeFree 12670525 Detail
0.001 Malignant tumor of cervix Polymorphisms in TP53 (rs1042522), p16 (rs11515 and rs3088440) and NQO1 (rs18005... BeFree 23534750 Detail
0.010 Preleukemia Lack of association between MDM2 SNP309 and TP53 Arg72Pro polymorphisms with cli... BeFree 22668018 Detail
0.022 medulloblastoma Prognostic value of the TP53 Arg72Pro single-nucleotide polymorphism and suscept... BeFree 22886512 Detail
0.132 melanoma MDM2 SNP309 and p53 Arg72Pro in cutaneous melanoma: association between SNP309 G... BeFree 20535124 Detail
0.466 Diabetes Mellitus, Non-Insulin-Dependent Using SNP- and gene-based analysis methods, we replicated previously reported SN... BeFree 18678618 Detail
0.004 uterine corpus cancer Association of MDM2 SNP309 and TP53 Arg72Pro polymorphisms with risk of endometr... BeFree 23624782 Detail
<0.001 Proliferative vitreoretinopathy The p53 codon 72 polymorphism (rs1042522) is associated with proliferative vitre... BeFree 23207172 Detail
0.001 cervix carcinoma Polymorphisms in TP53 (rs1042522), p16 (rs11515 and rs3088440) and NQO1 (rs18005... BeFree 23534750 Detail
0.005 Neoplasm Metastasis BRCA2 methylation frequency was 44%, p53 Pro22 allele frequency was 32% and hete... BeFree 25027116 Detail
0.240 Malignant neoplasm of breast Involvement of p53 R72P polymorphism in the association of MDM2-SNP309 with brea... BeFree 21479369 Detail
0.085 colorectal carcinoma TP53 Pro47Ser and Arg72Pro polymorphisms and colorectal cancer predisposition in... BeFree 20449797 Detail
<0.001 Malignant neoplasm of mouth To explore the role of polymorphisms of p53-related genes in etiology of oral ca... BeFree 22052649 Detail
0.080 breast carcinoma A case (n=250)-control (n=500) study was undertaken to investigate the role of S... BeFree 18058229 Detail
0.132 glioblastoma Our study suggests that the polymorphism of p53 codon 72 Arg/Pro may play a prot... BeFree 23860773 Detail
0.080 Carcinoma of lung The updated meta-analysis suggests that the p53 codon 72 Arg/Pro polymorphism is... BeFree 23812725 Detail
0.123 Nasopharyngeal carcinoma The results suggested that the Arg399Gln polymorphism of XRCC1 gene, the 1G/2G p... BeFree 25481674 Detail
0.075 stomach carcinoma This meta-analysis suggests that Pro allele in P53 Arg72Pro is significantly ass... BeFree 21376265 Detail
<0.001 Treatment related acute myeloid leukaemia MDM2 SNP309 and TP53 Arg72Pro interact to alter therapy-related acute myeloid le... BeFree 18426989 Detail
0.121 Malignant neoplasm of urinary bladder Quantitative assessment of the association between TP53 Arg72Pro polymorphism an... BeFree 23184052 Detail
0.003 endometrial carcinoma Association of p73 G4C14-to-A4T14 polymorphism at exon 2 and p53 Arg72Pro polymo... BeFree 15723718 Detail
0.003 squamous cell carcinoma An SNP, Arg72Pro, of the TP53 gene encoding a DNA damage response protein showed... BeFree 15609317 Detail
0.066 Malignant neoplasm of esophagus Among the five TP53 polymorphisms investigated, only p.R72P polymorphism may con... BeFree 25339039 Detail
0.090 Uterine Cervical Neoplasm [TP53 genetic polymorphisms and environmental risk factors associated with cervi... GAD 20563922 Detail
0.059 Malignant neoplasm of breast Combined effects of MDM2 SNP309 and TP53 R72P polymorphisms, and soy isoflavones... BeFree 21833626 Detail
0.031 esophageal carcinoma TP53 Arg72Pro polymorphism is associated with esophageal cancer risk: a meta-ana... BeFree 21448430 Detail
0.160 colorectal cancer Age of diagnosis of colorectal cancer in HNPCC patients is more complex than tha... BeFree 16353134 Detail
0.080 breast carcinoma An evaluation of the polymorphisms Ins16bp and Arg72Pro in p53 as breast cancer ... BeFree 18781154 Detail
0.440 squamous cell carcinoma Polymorphism Arg72Pro of p53 confers susceptibility to squamous cell carcinoma o... BeFree 23317414 Detail
0.001 gastric cardia adenocarcinoma This study examined the effect of P53 Arg72Pro variants on transactivation of po... BeFree 17638920 Detail
0.021 breast carcinoma The p53 Arg72Pro and MDM2 -309 polymorphisms and risk of breast cancer in the nu... BeFree 17387621 Detail
0.016 Glioma Association of p53 Arg72Pro and MDM2 SNP309 polymorphisms with glioma. BeFree 23096687 Detail
0.240 Malignant neoplasm of breast Association of p53 codon Arg72Pro and p73 G4C14-to-A4T14 at exon 2 genetic polym... BeFree 14634508 Detail
0.329 Glioma Association of p53 Arg72Pro and MDM2 SNP309 polymorphisms with glioma. BeFree 23096687 Detail
0.008 Hodgkin Disease The role of the TP53 gene's R72P polymorphism in non-Hodgkin lymphoma (NHL) has ... BeFree 21546086 Detail
<0.001 Lip and oral cavity carcinoma To explore the role of polymorphisms of p53-related genes in etiology of oral ca... BeFree 22052649 Detail
0.001 Malignant tumor of cervix Genetic polymorphisms of p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro and the r... BeFree 15036661 Detail
0.021 breast carcinoma Combined effects of MDM2 SNP309 and TP53 R72P polymorphisms, and soy isoflavones... BeFree 21833626 Detail
0.064 Carcinoma of bladder These data do not support an association between the p53 Arg72Pro polymorphism a... BeFree 11828992 Detail
0.017 Congenital chromosomal disease Association between TP53 gene ARG72PRO polymorphism and chromosome aberrations i... BeFree 20512840 Detail
0.059 Malignant neoplasm of breast The significance of MDM2 SNP309 and p53 Arg72Pro in young women with breast canc... BeFree 19639206 Detail
0.080 Carcinoma of lung The TP53 Arg72Pro polymorphism and lung cancer risk in a population of Northern ... BeFree 18336951 Detail
0.017 chronic lymphocytic leukemia Although the p53 R72P SNPs and MDM2 SNP309 did not associate with any of the par... BeFree 17981213 Detail
0.009 Lupus Erythematosus, Systemic Lack of association of the TP53 Arg72Pro SNP and the MDM2 SNP309 with systemic l... BeFree 19074170 Detail
0.022 medulloblastoma Loss of heterozygosity and p53 polymorphism Pro72Arg in a young patient with med... BeFree 12684657 Detail
0.010 adenocarcinoma We investigated the distribution of the p53 Arg72Pro (rs1042522) and MDM2 SNP309... BeFree 24175836 Detail
0.382 osteosarcoma Effect of TP53 Arg72Pro and MDM2 SNP309 polymorphisms on the risk of high-grade ... BeFree 19451596 Detail
0.226 melanoma Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105... BeFree 23568549 Detail
0.066 Malignant neoplasm of esophagus TP53 Arg72Pro polymorphism is associated with esophageal cancer risk: a meta-ana... BeFree 21448430 Detail
0.021 breast carcinoma Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large p... BeFree 17909070 Detail
<0.001 Treatment related acute myeloid leukaemia MDM2 SNP309 and TP53 Arg72Pro interact to alter therapy-related acute myeloid le... BeFree 18426989 Detail
0.080 breast carcinoma MDM2 SNP309 and TP53 R72P associated with severe and febrile neutropenia in brea... BeFree 21706156 Detail
0.160 Malignant neoplasm of lung The TP53 Arg72Pro polymorphism and lung cancer risk in a population of Northern ... BeFree 18336951 Detail
0.003 glaucoma Rare WDR36 variants and the P53 p.R72P polymorphism behaved as moderate glaucoma... BeFree 21931130 Detail
0.005 Malignant neoplasm of breast Epistatic interaction of Arg72Pro TP53 and -710 C/T VEGFR1 polymorphisms in brea... BeFree 23716179 Detail
0.085 colorectal carcinoma TP53 Arg72Pro polymorphism and colorectal cancer risk: a systematic review and m... BeFree 20615891 Detail
0.240 Malignant neoplasm of breast Pairwise analysis showed that combinations of the ERalpha G allele with the homo... BeFree 18820009 Detail
<0.001 uterine corpus cancer Association of p73 G4C14-to-A4T14 polymorphism at exon 2 and p53 Arg72Pro polymo... BeFree 15723718 Detail
0.001 Cutaneous Melanoma MDM2 SNP309 and p53 Arg72Pro in cutaneous melanoma: association between SNP309 G... BeFree 20535124 Detail
0.309 Esophageal Neoplasms These results suggest that p53 Arg72Pro polymorphism, but not GSTP1 Ile105Val, m... BeFree 20827430 Detail
0.080 breast carcinoma The present study was undertaken to investigate the association of p53 Arg72Pro,... BeFree 20233677 Detail
0.075 stomach carcinoma However, no overall association was found between the TP53 Arg72Pro polymorphism... BeFree 25190020 Detail
0.370 Diabetes Mellitus, Non-Insulin-Dependent Using SNP- and gene-based analysis methods, we replicated previously reported SN... BeFree 18678618 Detail
0.001 Malignant neoplasm of mouth To explore the role of polymorphisms of p53-related genes in etiology of oral ca... BeFree 22052649 Detail
0.369 Li-Fraumeni syndrome Impact of the MDM2 SNP309 and p53 Arg72Pro polymorphism on age of tumour onset i... BeFree 16258005 Detail
0.059 Malignant neoplasm of breast Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large p... BeFree 17909070 Detail
0.121 endometrial carcinoma Genotype misclassification in genetic association studies of the rs1042522 TP53 ... BeFree 23729685 Detail
0.003 cervix carcinoma We genotyped 4 single nucleotide polymorphisms (SNPs) with amino acid changes, T... BeFree 19482343 Detail
0.240 Malignant neoplasm of breast MDM2 SNP309 and TP53 R72P associated with severe and febrile neutropenia in brea... BeFree 21706156 Detail
0.066 Malignant neoplasm of esophagus In a large prospective cohort, p53 Arg72Pro Pro/Pro was associated with a 2-fold... BeFree 19383811 Detail
0.240 Malignant neoplasm of breast Functional MDM4 rs4245739 genetic variant, alone and in combination with P53 Arg... BeFree 23793604 Detail
0.002 Papillary thyroid carcinoma In the analyses of ATM/TP53 (rs1801516/rs664677/rs609429/rs1042522) combinations... BeFree 19286843 Detail
<0.001 Diabetes Mellitus, Non-Insulin-Dependent Studies of the association of Arg72Pro of tumor suppressor protein p53 with type... BeFree 21283750 Detail
0.020 Lip and oral cavity carcinoma To explore the role of polymorphisms of p53-related genes in etiology of oral ca... BeFree 22052649 Detail
0.003 hepatitis Subgroup analyses by source of controls and hepatitis virus infection status fur... BeFree 23564481 Detail
0.080 breast carcinoma Lack of influence of TP53 Arg72Pro and 16bp duplication polymorphisms on risk of... BeFree 25854391 Detail
0.240 Malignant neoplasm of breast An evaluation of the polymorphisms Ins16bp and Arg72Pro in p53 as breast cancer ... BeFree 18781154 Detail
0.008 melanoma Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105... BeFree 23568549 Detail
0.084 Malignant neoplasm of stomach Updated meta-analysis of the TP53 Arg72Pro polymorphism and gastric cancer risk. BeFree 22901123 Detail
0.151 schizophrenia Convergent evidence of the contribution of TP53 genetic variation (Pro72Arg) to ... BeFree 21296169 Detail
0.172 Squamous cell carcinoma of the head and neck Association between p53 Arg72Pro polymorphism and the risk of human papillomavir... BeFree 24289637 Detail
0.360 Malignant neoplasm of breast An evaluation of the polymorphisms Ins16bp and Arg72Pro in p53 as breast cancer ... BeFree 18781154 Detail
0.240 Malignant neoplasm of breast RAD51 135G&gt;C and TP53 Arg72Pro polymorphisms and susceptibility to breast can... BeFree 24114315 Detail
0.031 esophageal carcinoma Among the five TP53 polymorphisms investigated, only p.R72P polymorphism may con... BeFree 25339039 Detail
0.004 Squamous cell carcinoma of lung Elevated risk of squamous-cell carcinoma of the lung in heavy smokers carrying t... BeFree 17059853 Detail
0.160 colorectal cancer Association between p53 Arg72Pro polymorphism and colorectal cancer risk: a meta... BeFree 21124037 Detail
0.017 uterine corpus cancer Association of MDM2 SNP309 and TP53 Arg72Pro polymorphisms with risk of endometr... BeFree 23624782 Detail
<0.001 schizophrenia Though rs1042522 and rs8064946 did not show positive association with schizophre... BeFree 15450681 Detail
0.080 breast carcinoma Pairwise analysis showed that combinations of the ERalpha G allele with the homo... BeFree 18820009 Detail
<0.001 Malignant neoplasm of endometrium Association of p73 G4C14-to-A4T14 polymorphism at exon 2 and p53 Arg72Pro polymo... BeFree 15723718 Detail
0.029 Malignant neoplasm of mouth No significant association between p53 codon 72 Arg/Pro polymorphism and risk of... BeFree 23192640 Detail
0.240 Malignant neoplasm of breast These findings indicate that the SNPs in P53BP1 and p53 jointly contribute to br... BeFree 16314399 Detail
0.080 breast carcinoma The p53 R72P polymorphism has been suggested to play a role in many cancers, inc... BeFree 16033823 Detail
<0.001 endometrial carcinoma Association of p73 G4C14-to-A4T14 polymorphism at exon 2 and p53 Arg72Pro polymo... BeFree 15723718 Detail
0.031 rheumatoid arthritis Association of rheumatoid arthritis with Mdm2 SNP309 and genetic evidence for an... BeFree 19772793 Detail
0.085 ovarian carcinoma Effect of the codon 72 polymorphism (c.215G&gt;C, p.Arg72Pro) in combination wit... BeFree 15221786 Detail
0.080 Carcinogenesis In addition to TP53 gene mutations, a common polymorphism, Arg72Pro, has been in... BeFree 18068527 Detail
0.240 Malignant neoplasm of breast The present study was undertaken to investigate the association of p53 Arg72Pro,... BeFree 20233677 Detail
0.017 colorectal cancer TP53 R72P and MDM2 SNP309 polymorphisms and colorectal cancer risk: the Fukuoka ... BeFree 21051533 Detail
0.009 Well Differentiated Oligodendroglioma Aiming to study the role of TP53 Pro47Ser and Arg72Pro on glioma susceptibility ... BeFree 18393224 Detail
<0.001 leukopenia MDM2 SNP309 and TP53 R72P are significantly associated with severe neutropenia a... BeFree 21706156 Detail
<0.001 neutropenia MDM2 rs2279744 and TP53 rs1042522 polymorphisms associated with etoposide- and c... BeFree 24732641 Detail
0.121 Malignant neoplasm of urinary bladder These data do not support an association between the p53 Arg72Pro polymorphism a... BeFree 11828992 Detail
0.230 Malignant neoplasm of prostate Detection of human papillomavirus (HPV) DNA prevalence and p53 codon 72 (Arg72Pr... BeFree 25213701 Detail
0.163 Epithelial ovarian cancer Effect of the codon 72 polymorphism (c.215G&gt;C, p.Arg72Pro) in combination wit... BeFree 15221786 Detail
0.121 Malignant neoplasm of urinary bladder Role of TP53 Arg72Pro polymorphism in urinary bladder cancer predisposition and ... BeFree 21156242 Detail
0.005 Hereditary Nonpolyposis Colorectal Cancer Age of diagnosis of CRC in HNPCC patients is therefore more complex than that pr... BeFree 16353134 Detail
0.163 lymphoma Through searching PubMed databases (or hand searching) up to April 2012 using th... BeFree 23029260 Detail
0.121 endometrial carcinoma Association of p73 G4C14-to-A4T14 polymorphism at exon 2 and p53 Arg72Pro polymo... BeFree 15723718 Detail
0.003 Oropharyngeal Carcinoma Stratification analyses showed that a reduced risk associated with the -606CC ge... BeFree 20935061 Detail
0.080 Carcinoma of lung The association between TP53 Arg72Pro polymorphism and lung cancer susceptibilit... BeFree 23595658 Detail
0.080 breast carcinoma An evaluation of the polymorphisms Ins16bp and Arg72Pro in p53 as breast cancer ... BeFree 18781154 Detail
0.440 squamous cell carcinoma We evaluated the effect of MDM2 SNP309 and its interaction with the p53 Arg72Pro... BeFree 18814047 Detail
0.511 liver carcinoma However, we did not find any main effect of TP53 Arg72Pro on HCC risk in this po... BeFree 20309940 Detail
0.240 Malignant neoplasm of breast Lack of influence of TP53 Arg72Pro and 16bp duplication polymorphisms on risk of... BeFree 25854391 Detail
0.038 sarcoma The functional MDM2 T309G genetic variant but not P53 Arg72Pro polymorphism is a... BeFree 22205265 Detail
0.132 Adenocarcinoma Of Esophagus In subgroup analyses based on pathological type, the Pro variant was significant... BeFree 20389250 Detail
0.005 Non-small cell lung carcinoma We evaluated seven single-nucleotide polymorphisms of six genes CDA Lys27Gln (A/... BeFree 22052224 Detail
0.075 stomach carcinoma Pro variant of TP53 Arg72Pro contributes to gastric cancer risk in Asians: evide... BeFree 22631671 Detail
0.248 Mammary Neoplasms We investigated the effects of the germ-line single nucleotide polymorphisms TP5... BeFree 20021639 Detail
0.007 Breast Cancer, Familial The R72P P53 mutation is associated with familial breast cancer in Jewish women. BeFree 15756275 Detail
0.005 Leukemia, Lymphocytic, Acute, L1 TP53 R72P and MDM2 SNP309 polymorphisms in modification of childhood acute lymph... BeFree 19837266 Detail
0.080 breast carcinoma TGFbeta1 (Leu10Pro), p53 (Arg72Pro) can predict for increased risk for breast ca... BeFree 18058229 Detail
<0.001 Small cell lung cancer extensive stage MDM2 rs2279744 and TP53 rs1042522 SNPs were associated with EP-induced high-grad... BeFree 24732641 Detail
0.031 Osteosarcoma of bone Effect of TP53 Arg72Pro and MDM2 SNP309 polymorphisms on the risk of high-grade ... BeFree 19451596 Detail
0.166 Brain Neoplasms Our results suggest a possible association between P53 Arg72Pro polymorphisms an... BeFree 15950766 Detail
0.121 endometrial carcinoma TP53 Arg72Pro polymorphism and endometrial cancer risk: a meta-analysis. BeFree 20552298 Detail
0.230 Malignant neoplasm of prostate Although we did not find a significant relationship between the frequency of the... BeFree 17785557 Detail
0.064 Carcinoma of bladder Role of TP53 Arg72Pro polymorphism in urinary bladder cancer predisposition and ... BeFree 21156242 Detail
0.102 Malignant neoplasm of breast A case (n=250)-control (n=500) study was undertaken to investigate the role of S... BeFree 18058229 Detail
0.181 Neoplasm Metastasis Genetic polymorphisms in the 3'UTR region of the CXCL12 (rs1801157) and TP53 cod... BeFree 23653000 Detail
<0.001 gastric cardia carcinoma Interaction of P53 Arg72Pro and MDM2 T309G polymorphisms and their associations ... BeFree 17638920 Detail
0.002 Leukemia, Lymphocytic, Acute, L1 TP53 R72P and MDM2 SNP309 polymorphisms in modification of childhood acute lymph... BeFree 19837266 Detail
0.006 Osteosarcoma of bone Effect of TP53 Arg72Pro and MDM2 SNP309 polymorphisms on the risk of high-grade ... BeFree 19451596 Detail
<0.001 Cutaneous Melanoma Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105... BeFree 23568549 Detail
0.003 colorectal cancer We have previously reported that the common, functionally different variants Arg... BeFree 17224235 Detail
0.031 multiple myeloma Through searching PubMed databases (or hand searching) up to April 2012 using th... BeFree 23029260 Detail
0.066 Malignant neoplasm of esophagus Modeling gene-environment interactions in oral cavity and esophageal cancers dem... BeFree 23475592 Detail
0.080 Carcinoma of lung TP53 Arg72Pro polymorphism and lung cancer risk: a meta-analysis. BeFree 19623649 Detail
0.011 Hepatitis B, Chronic This study investigated the influence of combined p53 Arg72Pro and MDM2 SNP309 o... BeFree 23292895 Detail
0.219 Non-small cell lung carcinoma We evaluated seven single-nucleotide polymorphisms of six genes CDA Lys27Gln (A/... BeFree 22052224 Detail
<0.001 Diabetes Mellitus, Non-Insulin-Dependent Studies of the association of Arg72Pro of tumor suppressor protein p53 with type... BeFree 21283750 Detail
0.038 Malignant neoplasm of lung Therefore, we hypothesized that the genetic variants in these three genes influe... BeFree 16912209 Detail
0.240 Malignant neoplasm of breast Association of p53 genetic polymorphism (Arg72Pro) with estrogen receptor positi... BeFree 15183535 Detail
0.030 Carcinoma of lung Therefore, we hypothesized that the genetic variants in these three genes influe... BeFree 16912209 Detail
0.440 squamous cell carcinoma Our data indicate that the TP53 Arg72Pro polymorphism increases the risk for squ... BeFree 17059853 Detail
0.080 breast carcinoma Epistatic interaction of Arg72Pro TP53 and -710 C/T VEGFR1 polymorphisms in brea... BeFree 23716179 Detail
0.008 Hodgkin Disease This meta-analysis indicates that the p53 Arg72Pro polymorphism may contribute t... BeFree 23029260 Detail
0.330 Diabetes Mellitus, Non-Insulin-Dependent Using SNP- and gene-based analysis methods, we replicated previously reported SN... BeFree 18678618 Detail
0.511 liver carcinoma Because our results suggest for the first time that the Pro/Pro homozygote of p5... BeFree 21607615 Detail
0.213 cervix carcinoma The results indicated that the polymorphism in TP53 (rs1042522) might be associa... BeFree 23534750 Detail
<0.001 neutropenia MDM2 rs2279744 and TP53 rs1042522 polymorphisms associated with etoposide- and c... BeFree 24732641 Detail
0.080 Carcinoma of lung Present report evaluated the association of polymorphism in exon 4 Arg72Pro (G&g... BeFree 23317414 Detail
0.059 Malignant neoplasm of breast The p53 Arg72Pro and MDM2 -309 polymorphisms and risk of breast cancer in the nu... BeFree 17387621 Detail
0.003 Diabetes Mellitus, Non-Insulin-Dependent Using SNP- and gene-based analysis methods, we replicated previously reported SN... BeFree 18678618 Detail
0.085 colorectal carcinoma Association between p53 Arg72Pro polymorphism and colorectal cancer risk: a meta... BeFree 21124037 Detail
0.007 Carcinoma of lung Four of the variants were found to be weakly associated with lung cancer risk wi... BeFree 18990748 Detail
<0.001 gastric cardia carcinoma Interaction of P53 Arg72Pro and MDM2 T309G polymorphisms and their associations ... BeFree 17638920 Detail
0.075 stomach carcinoma Updated meta-analysis of the TP53 Arg72Pro polymorphism and gastric cancer risk. BeFree 22901123 Detail
0.160 Malignant neoplasm of lung The updated meta-analysis suggests that the p53 codon 72 Arg/Pro polymorphism is... BeFree 23812725 Detail
0.160 Malignant neoplasm of lung Lack of evidence that p53 Arg72Pro influences lung cancer prognosis: an analysis... BeFree 17400332 Detail
0.240 Malignant neoplasm of breast Combined effects of MDM2 SNP309 and TP53 R72P polymorphisms, and soy isoflavones... BeFree 21833626 Detail
0.323 Neoplasm Metastasis Genetic polymorphisms in the 3'UTR region of the CXCL12 (rs1801157) and TP53 cod... BeFree 23653000 Detail
0.102 Malignant neoplasm of breast Role of GSTM1 (Null/Present), GSTP1 (Ile105Val) and P53 (Arg72Pro) genetic polym... BeFree 17696741 Detail
0.123 Malignant neoplasm of ovary Meta-analysis shows significant association of the TP53 Arg72Pro with ovarian ca... BeFree 21952824 Detail
0.059 Malignant neoplasm of breast Individual and combined effects of MDM2 SNP309 and TP53 Arg72Pro on breast cance... BeFree 22729912 Detail
0.006 colorectal carcinoma TP53 R72P and MDM2 SNP309 polymorphisms and colorectal cancer risk: the Fukuoka ... BeFree 21051533 Detail
0.085 colorectal carcinoma Few reports have investigated the association of two p53 polymorphisms (Arg72Pro... BeFree 17374954 Detail
0.002 Nasopharyngeal carcinoma The results suggested that the Arg399Gln polymorphism of XRCC1 gene, the 1G/2G p... BeFree 25481674 Detail
0.006 Papillary thyroid carcinoma In the analyses of ATM/TP53 (rs1801516/rs664677/rs609429/rs1042522) combinations... BeFree 19286843 Detail
0.353 Mammary Neoplasms In addition, the Arg72Pro genotype of 116 breast tumors was determined, and corr... BeFree 23071787 Detail
0.021 breast carcinoma The significance of MDM2 SNP309 and p53 Arg72Pro in young women with breast canc... BeFree 19639206 Detail
0.039 Malignant neoplasm of pancreas This meta-analysis suggests that Pro allele in P53 Arg72Pro is significantly ass... BeFree 21376265 Detail
0.008 breast carcinoma Functional MDM4 rs4245739 genetic variant, alone and in combination with P53 Arg... BeFree 23793604 Detail
0.226 melanoma MDM2 SNP309 and p53 Arg72Pro in cutaneous melanoma: association between SNP309 G... BeFree 20535124 Detail
0.064 Carcinoma of bladder Quantitative assessment of the association between TP53 Arg72Pro polymorphism an... BeFree 23184052 Detail
0.160 colorectal cancer Few reports have investigated the association of two p53 polymorphisms (Arg72Pro... BeFree 17374954 Detail
0.022 breast carcinoma A case (n=250)-control (n=500) study was undertaken to investigate the role of S... BeFree 18058229 Detail
0.329 Glioma The relationship of p53 codon 72 Arg/Pro polymorphism with the susceptibility to... BeFree 23860773 Detail
0.123 Malignant neoplasm of ovary We conducted a case-control study in order to investigate the association of RAD... BeFree 24114315 Detail
0.002 gallbladder carcinoma These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and t... BeFree 17531965 Detail
0.016 myelodysplastic syndrome The relationship of TP53 R72P polymorphism to disease outcome and TP53 mutation ... BeFree 25768405 Detail
0.132 melanoma Investigation of the effect of MDM2 SNP309 and TP53 Arg72Pro polymorphisms on th... BeFree 22336942 Detail
0.080 breast carcinoma Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large p... BeFree 17909070 Detail
<0.001 endometriosis To examine whether TP53 polymorphisms may be involved with in vitro fertilizatio... BeFree 23013791 Detail
0.121 Malignant neoplasm of urinary bladder Meta-analysis of association between TP53 Arg72Pro polymorphism and bladder canc... BeFree 20630574 Detail
0.248 Mammary Neoplasms Association of the germline TP53 R72P and MDM2 SNP309 variants with breast cance... BeFree 21667122 Detail
0.002 Infiltrating Cervical Carcinoma We performed a case-control association study to evaluate the association betwee... BeFree 24474455 Detail
0.133 Malignant neoplasm of breast Functional MDM4 rs4245739 genetic variant, alone and in combination with P53 Arg... BeFree 23793604 Detail
0.001 Diabetes Mellitus, Non-Insulin-Dependent Using SNP- and gene-based analysis methods, we replicated previously reported SN... BeFree 18678618 Detail
0.066 Malignant neoplasm of esophagus Association of p53 Arg72Pro polymorphism with esophageal cancer: a meta-analysis... BeFree 23844939 Detail
0.240 Malignant neoplasm of breast The results of present study indicated that among the five TP53 polymorphisms in... BeFree 25169539 Detail
<0.001 leukopenia MDM2 rs2279744 and TP53 rs1042522 polymorphisms associated with etoposide- and c... BeFree 24732641 Detail
0.021 breast carcinoma We pooled data from four breast cancer cohorts within the Breast Cancer Associat... BeFree 20021639 Detail
0.511 liver carcinoma Association between the p53 codon 72 Arg/Pro polymorphism and hepatocellular car... BeFree 23564481 Detail
0.240 Malignant neoplasm of breast Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large p... BeFree 17909070 Detail
0.511 liver carcinoma TP53 R72P polymorphism modulates DNA methylation in hepatocellular carcinoma. BeFree 25889455 Detail
0.353 Mammary Neoplasms We investigated the effects of the germ-line single nucleotide polymorphisms TP5... BeFree 20021639 Detail
0.059 Malignant neoplasm of breast Association of the germline TP53 R72P and MDM2 SNP309 variants with breast cance... BeFree 21667122 Detail
0.037 hepatitis B Thus, MDM2 SNP 309 and p53 Arg72Pro are associated with the early development of... BeFree 18390844 Detail
0.022 breast carcinoma Role of GSTM1 (Null/Present), GSTP1 (Ile105Val) and P53 (Arg72Pro) genetic polym... BeFree 17696741 Detail
0.084 Malignant neoplasm of stomach However, no overall association was found between the TP53 Arg72Pro polymorphism... BeFree 25190020 Detail
<0.001 gastric cardia adenocarcinoma This study examined the effect of P53 Arg72Pro variants on transactivation of po... BeFree 17638920 Detail
0.006 Cutaneous Melanoma Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105... BeFree 23568549 Detail
0.080 breast carcinoma Association of p53 genetic polymorphism (Arg72Pro) with estrogen receptor positi... BeFree 15183535 Detail
0.007 Sporadic Breast Carcinoma Haplotype analysis of p53 polymorphisms: Arg72Pro, Ins16bp and G13964C in Tunisi... BeFree 20233677 Detail
0.021 oligodendroglioma Aiming to study the role of TP53 Pro47Ser and Arg72Pro on glioma susceptibility ... BeFree 18393224 Detail
0.480 Malignant neoplasm of breast An evaluation of the polymorphisms Ins16bp and Arg72Pro in p53 as breast cancer ... BeFree 18781154 Detail
0.114 Malignant neoplasm of breast Pairwise analysis showed that combinations of the ERalpha G allele with the homo... BeFree 18820009 Detail
<0.001 endometrial carcinoma We searched multiple databases (through March 8, 2011) for studies investigating... BeFree 23729685 Detail
0.003 Nasopharyngeal carcinoma The results suggested that the Arg399Gln polymorphism of XRCC1 gene, the 1G/2G p... BeFree 25481674 Detail
0.004 Huntington disease Age at onset of Huntington disease is not modulated by the R72P variation in TP5... BeFree 16202123 Detail
0.039 Cervical Intraepithelial Neoplasia The results of our study suggest that combined analysis of TP53 polymorphisms Ar... BeFree 24782034 Detail
0.080 breast carcinoma RAD51 135G&gt;C and TP53 Arg72Pro polymorphisms and susceptibility to breast can... BeFree 24114315 Detail
0.006 Cutaneous Melanoma Investigation of the effect of MDM2 SNP309 and TP53 Arg72Pro polymorphisms on th... BeFree 22336942 Detail
0.157 Leukemia, Myelocytic, Acute Postchemotherapy response analysis revealed that AML patients heterozygous for A... BeFree 20232390 Detail
0.020 Lip and oral cavity carcinoma Polymorphism of the p53 codon 72 Arg/Pro and the risk of HPV type 16/18-associat... BeFree 14577584 Detail
0.240 Malignant neoplasm of breast Association of p53 genetic polymorphism (Arg72Pro) with estrogen receptor positi... BeFree 15183535 Detail
0.080 breast carcinoma Association of p53 genetic polymorphism (Arg72Pro) with estrogen receptor positi... BeFree 15183535 Detail
<0.001 colorectal carcinoma We have previously reported that the common, functionally different variants Arg... BeFree 17224235 Detail
0.160 colorectal cancer Association of Arg72Pro of P53 polymorphism with colorectal cancer susceptibilit... BeFree 22393962 Detail
0.240 Malignant neoplasm of breast A case (n=250)-control (n=500) study was undertaken to investigate the role of S... BeFree 18058229 Detail
0.121 Malignant neoplasm of urinary bladder The role of TP53 PRO47SER and ARG72PRO single nucleotide polymorphisms in the su... BeFree 19523860 Detail
<0.001 leukopenia MDM2 rs2279744 and TP53 rs1042522 polymorphisms associated with etoposide- and c... BeFree 24732641 Detail
<0.001 Malignant neoplasm of endometrium Association of p73 G4C14-to-A4T14 polymorphism at exon 2 and p53 Arg72Pro polymo... BeFree 15723718 Detail
0.001 Lip and oral cavity carcinoma To explore the role of polymorphisms of p53-related genes in etiology of oral ca... BeFree 22052649 Detail
0.085 colorectal carcinoma Association of Arg72Pro of P53 polymorphism with colorectal cancer susceptibilit... BeFree 22393962 Detail
<0.001 Blast Phase Two functional single nucleotide polymorphisms (SNPs), p53 R72P and MDM2 SNP309,... BeFree 23818300 Detail
0.160 colorectal cancer TP53 R72P and MDM2 SNP309 polymorphisms and colorectal cancer risk: the Fukuoka ... BeFree 21051533 Detail
0.020 Lip and oral cavity carcinoma No significant association between p53 codon 72 Arg/Pro polymorphism and risk of... BeFree 23192640 Detail
0.016 myelodysplastic syndrome Lack of association between MDM2 SNP309 and TP53 Arg72Pro polymorphisms with cli... BeFree 22668018 Detail
<0.001 leukopenia MDM2 SNP309 and TP53 R72P are significantly associated with severe neutropenia a... BeFree 21706156 Detail
0.003 Hepatitis B, Chronic This study investigated the influence of combined p53 Arg72Pro and MDM2 SNP309 o... BeFree 23292895 Detail
Annotation

Annotations

DescrptionSourceLinks
Large meta-analysis of 5,191 breast cancer patients and 3,834 controls did not find a conclusive lin... CIViC Evidence Detail
Pooled data from 13 studies of patients with lung cancer found little effect of codon 72 allele on t... CIViC Evidence Detail
In a relatively small meta-analysis of 119 women with cervical cancer and 127 controls, associations... CIViC Evidence Detail
NM_000546.6(TP53):c.215C>G (p.Pro72Arg) AND CODON 72 POLYMORPHISM ClinVar Detail
NM_000546.6(TP53):c.215C>G (p.Pro72Arg) AND not provided ClinVar Detail
NM_000546.6(TP53):c.215C>G (p.Pro72Arg) AND not specified ClinVar Detail
NM_000546.6(TP53):c.215C>G (p.Pro72Arg) AND Hereditary cancer-predisposing syndrome ClinVar Detail
NM_000546.6(TP53):c.215C>G (p.Pro72Arg) AND Li-Fraumeni syndrome 1 ClinVar Detail
NM_000546.6(TP53):c.215C>G (p.Pro72Arg) AND Li-Fraumeni syndrome ClinVar Detail
NM_000546.6(TP53):c.215C>G (p.Pro72Arg) AND Lip and oral cavity carcinoma ClinVar Detail
NM_000546.6(TP53):c.215C>G (p.Pro72Arg) AND Hereditary breast ovarian cancer syndrome ClinVar Detail
NM_000546.6(TP53):c.215C>G (p.Pro72Arg) AND multiple conditions ClinVar Detail
NM_000546.6(TP53):c.215C>G (p.Pro72Arg) AND multiple conditions ClinVar Detail
NM_000546.6(TP53):c.215C>G (p.Pro72Arg) AND multiple conditions ClinVar Detail
NM_000546.6(TP53):c.215C>G (p.Pro72Arg) AND multiple conditions ClinVar Detail
NM_000546.6(TP53):c.215C>G (p.Pro72Arg) AND multiple conditions ClinVar Detail
NM_000546.6(TP53):c.215C>G (p.Pro72Arg) AND multiple conditions ClinVar Detail
NM_000546.6(TP53):c.215C>G (p.Pro72Arg) AND multiple conditions ClinVar Detail
NM_000546.6(TP53):c.215C>G (p.Pro72Arg) AND multiple conditions ClinVar Detail
NM_000546.6(TP53):c.215C>G (p.Pro72Arg) AND multiple conditions ClinVar Detail
NM_000546.6(TP53):c.215C>G (p.Pro72Arg) AND multiple conditions ClinVar Detail
NM_000546.6(TP53):c.215C>G (p.Pro72Arg) AND multiple conditions ClinVar Detail
NM_000546.6(TP53):c.215C>G (p.Pro72Arg) AND multiple conditions ClinVar Detail
NM_000546.6(TP53):c.215C>G (p.Pro72Arg) AND Acute myeloid leukemia ClinVar Detail
We therefore investigated the combined effects of polymorphisms in TP53 (Arg72Pro) and p21/CDKN1A (S... DisGeNET Detail
Association between XRCC1 ARG399GLN and P53 ARG72PRO polymorphisms and the risk of gastric and color... DisGeNET Detail
We therefore tested associations between CYP1A1 T3801C, CYP1A1 Ile462Val, GSTM1deletion, and TP53 Ar... DisGeNET Detail
Pairwise analysis showed that combinations of the ERalpha G allele with the homozygous Trp genotype ... DisGeNET Detail
A case (n=250)-control (n=500) study was undertaken to investigate the role of Single Nucleotide Pol... DisGeNET Detail
The Arg variant of p53 Arg72Pro is associated with progression of SIL to cervical cancer only in the... DisGeNET Detail
To investigate the associations of TP53 R72P and MDM2 T309G SNPs with HPV infection status, HPV onco... DisGeNET Detail
The p53 R72P genotype was identified by polymerase chain reaction-restriction fragment length polymo... DisGeNET Detail
This study aimed to evaluate the prognostic significance of two functional single nucleotide polymor... DisGeNET Detail
Association between XRCC1 ARG399GLN and P53 ARG72PRO polymorphisms and the risk of gastric and color... DisGeNET Detail
The TP53 gene polymorphisms, Arg72Pro and PIN3 (+16 bp), can have prognostic and predictive value in... DisGeNET Detail
Meta-analysis demonstrates association between Arg72Pro polymorphism in the P53 gene and susceptibil... DisGeNET Detail
This study investigated whether the functional polymorphisms in P53 pathway genes, P53 Arg72Pro (rs1... DisGeNET Detail
Pro variant of TP53 Arg72Pro contributes to gastric cancer risk in Asians: evidence from a meta-anal... DisGeNET Detail
Individual and combined effects of MDM2 SNP309 and TP53 Arg72Pro on breast cancer risk: an updated m... DisGeNET Detail
Lack of evidence that p53 Arg72Pro influences lung cancer prognosis: an analysis of survival in 619 ... DisGeNET Detail
Meta-analysis of association between the TP53 Arg72Pro polymorphism and risk of endometriosis based ... DisGeNET Detail
MDM2 SNP309 and TP53 R72P are significantly associated with severe neutropenia and FN, respectively,... DisGeNET Detail
Effect of TP53 Arg72Pro and MDM2 SNP309 polymorphisms on the risk of high-grade osteosarcoma develop... DisGeNET Detail
Among the natural sequence variants of TP53, rs1042522 (R72P) modifies the risk for solid tumors. DisGeNET Detail
Polymorphisms of p53 Arg(72)Pro and p21 Ser(31)Arg did not show significant association with RCC. DisGeNET Detail
Using SNP- and gene-based analysis methods, we replicated previously reported SNP-type 2 diabetes as... DisGeNET Detail
Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105Val) polymorphisms i... DisGeNET Detail
We evaluated the effect of MDM2 SNP309 and its interaction with the p53 Arg72Pro polymorphism on pig... DisGeNET Detail
Investigation of the effect of MDM2 SNP309 and TP53 Arg72Pro polymorphisms on the age of onset of cu... DisGeNET Detail
The results suggested that the Arg399Gln polymorphism of XRCC1 gene, the 1G/2G polymorphism of MMP-1... DisGeNET Detail
The current case-control study was conducted in order to elucidate any possible association of the s... DisGeNET Detail
These findings indicate that the SNPs in P53BP1 and p53 jointly contribute to breast cancer risk, pa... DisGeNET Detail
Involvement of p53 R72P polymorphism in the association of MDM2-SNP309 with breast cancer. DisGeNET Detail
We failed to confirm earlier reports of increased cervical cancer susceptibility in women who harbor... DisGeNET Detail
Specifically, 2 polymorphisms-an arginine-to-glutamine substitution at codon 399 (Q399R) in XRCC1 an... DisGeNET Detail
Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105Val) polymorphisms i... DisGeNET Detail
Association of p73 G4C14-to-A4T14 polymorphism at exon 2 and p53 Arg72Pro polymorphism with the risk... DisGeNET Detail
Involvement of p53 R72P polymorphism in the association of MDM2-SNP309 with breast cancer. DisGeNET Detail
This meta-analysis suggests that Pro allele in P53 Arg72Pro is significantly associated with the inc... DisGeNET Detail
To explore the role of polymorphisms of p53-related genes in etiology of oral cancer, we investigate... DisGeNET Detail
Association between XRCC1 ARG399GLN and P53 ARG72PRO polymorphisms and the risk of gastric and color... DisGeNET Detail
We genotyped 4 single nucleotide polymorphisms (SNPs) with amino acid changes, TP53 Pro72Arg (rs1042... DisGeNET Detail
We searched multiple databases (through March 8, 2011) for studies investigating the association of ... DisGeNET Detail
The significance of MDM2 SNP309 and p53 Arg72Pro in young women with breast cancer. DisGeNET Detail
Association of p53 codon Arg72Pro and p73 G4C14-to-A4T14 at exon 2 genetic polymorphisms with the ri... DisGeNET Detail
We pooled data from four breast cancer cohorts within the Breast Cancer Association Consortium for w... DisGeNET Detail
Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105Val) polymorphisms i... DisGeNET Detail
Association between p53 Arg72Pro polymorphism and thyroid cancer risk: a meta-analysis. DisGeNET Detail
Involvement of p53 R72P polymorphism in the association of MDM2-SNP309 with breast cancer. DisGeNET Detail
Genotype misclassification in genetic association studies of the rs1042522 TP53 (Arg72Pro) polymorph... DisGeNET Detail
Association of MDM2 SNP309 and TP53 Arg72Pro polymorphisms with risk of endometrial cancer. DisGeNET Detail
In case-only analysis, the homozygous p73 G4C14-to-A4T14 variant of p73 genotype was associated with... DisGeNET Detail
When all 11 studies were pooled into the analysis, an increased esophageal cancer risk was significa... DisGeNET Detail
Detection of human papillomavirus (HPV) DNA prevalence and p53 codon 72 (Arg72Pro) polymorphism in p... DisGeNET Detail
We evaluated seven single-nucleotide polymorphisms of six genes CDA Lys27Gln (A/C); CDA C435T; ERCC1... DisGeNET Detail
The additive effect of p53 Arg72Pro and RNASEL Arg462Gln genotypes on age of disease onset in Lynch ... DisGeNET Detail
Association of MDM2 T309G and p53 Arg72Pro polymorphisms and gastroesophageal reflux disease with su... DisGeNET Detail
Age of diagnosis of colorectal cancer in HNPCC patients is more complex than that predicted by R72P ... DisGeNET Detail
Role of GSTM1 (Null/Present), GSTP1 (Ile105Val) and P53 (Arg72Pro) genetic polymorphisms and the ris... DisGeNET Detail
The p53 Arg72Pro polymorphism, human papillomavirus, and invasive squamous cell cervical cancer. DisGeNET Detail
TP53 Arg72Pro polymorphism (rs1042522) and risk of endometriosis among Asian and Caucasian populatio... DisGeNET Detail
Prognostic value of TP53 Pro47Ser and Arg72Pro single nucleotide polymorphisms and the susceptibilit... DisGeNET Detail
Polymorphisms of p53 Arg72Pro, p73 G4C14-to-A4T14 at exon 2 and p21 Ser31Arg and the risk of non-Hod... DisGeNET Detail
The functional MDM2 T309G genetic variant but not P53 Arg72Pro polymorphism is associated with risk ... DisGeNET Detail
Cox regression analysis showed p53 Arg72Pro heterozygous genotype was overall an independent prognos... DisGeNET Detail
This study aimed to evaluate the prognostic significance of two functional single nucleotide polymor... DisGeNET Detail
The p53 R72P polymorphism does not influence cervical cancer development in a Portuguese population:... DisGeNET Detail
Association of MDM2 T309G and p53 Arg72Pro polymorphisms and gastroesophageal reflux disease with su... DisGeNET Detail
We here studied the association of rs1219648 in FGFR2 and rs1042522 in TP53 and their interaction in... DisGeNET Detail
MDM2 SNP309 and p53 Arg72Pro in cutaneous melanoma: association between SNP309 GG genotype and tumor... DisGeNET Detail
Association of rs1219648 in FGFR2 and rs1042522 in TP53 with premenopausal breast cancer in an Irani... DisGeNET Detail
Functional MDM4 rs4245739 genetic variant, alone and in combination with P53 Arg72Pro polymorphism, ... DisGeNET Detail
Association of the germline TP53 R72P and MDM2 SNP309 variants with breast cancer survival in specif... DisGeNET Detail
Frequency of TP53 mutations in relation to Arg72Pro genotypes in non small cell lung cancer. DisGeNET Detail
Four of the variants were found to be weakly associated with lung cancer risk with borderline signif... DisGeNET Detail
We evaluated the effect of MDM2 SNP309 and its interaction with the p53 Arg72Pro polymorphism on pig... DisGeNET Detail
We demonstrated that the polymorphism in TP53 (rs1042522) was associated with type 2 diabetes, and t... DisGeNET Detail
These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and the Pro allele of TP5... DisGeNET Detail
TP53 Arg72Pro polymorphism and lung cancer risk: a meta-analysis. DisGeNET Detail
Therefore, we hypothesized that the genetic variants in these three genes influence the predispositi... DisGeNET Detail
We did not observe any statistically significant association between the p53 Arg72Pro polymorphism a... DisGeNET Detail
TP53 Arg72Pro polymorphism and colorectal cancer risk: a systematic review and meta-analysis. DisGeNET Detail
In order to examine the role of the p53 gene for the pathogenesis of schizophrenic disorders, patien... DisGeNET Detail
TP53 Arg72Pro polymorphism and skin cancer risk: a meta-analysis. DisGeNET Detail
Association of MDM2 T309G and p53 Arg72Pro polymorphisms and gastroesophageal reflux disease with su... DisGeNET Detail
TGFbeta1 (Leu10Pro), p53 (Arg72Pro) can predict for increased risk for breast cancer in south Indian... DisGeNET Detail
Homozygosity for Pro of p53 Arg72Pro as a potential risk factor for hepatocellular carcinoma in Chin... DisGeNET Detail
The human Tp53 Arg72Pro polymorphism explains different functional prognosis in stroke. DisGeNET Detail
The significance of MDM2 SNP309 and p53 Arg72Pro in young women with breast cancer. DisGeNET Detail
The Arg variant of p53 Arg72Pro is associated with progression of SIL to cervical cancer only in the... DisGeNET Detail
We conducted a case-control study in order to investigate the association of RAD51 135G&gt;C and TP5... DisGeNET Detail
The p53 Arg72Pro and MDM2 -309 polymorphisms and risk of breast cancer in the nurses' health studies... DisGeNET Detail
In a large prospective cohort, p53 Arg72Pro Pro/Pro was associated with a 2-fold increased risk of d... DisGeNET Detail
Association of rheumatoid arthritis with Mdm2 SNP309 and genetic evidence for an allele-specific int... DisGeNET Detail
We therefore tested associations between CYP1A1 T3801C, CYP1A1 Ile462Val, GSTM1deletion, and TP53 Ar... DisGeNET Detail
Association of rs1219648 in FGFR2 and rs1042522 in TP53 with premenopausal breast cancer in an Irani... DisGeNET Detail
Genetic polymorphisms of p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro and the risk of cervical canc... DisGeNET Detail
Association of p53 codon Arg72Pro and p73 G4C14-to-A4T14 at exon 2 genetic polymorphisms with the ri... DisGeNET Detail
We evaluated seven single-nucleotide polymorphisms of six genes CDA Lys27Gln (A/C); CDA C435T; ERCC1... DisGeNET Detail
Recent studies have shown a significant correlation between the presence of p53 Arg72Pro polymorphis... DisGeNET Detail
We have previously reported that the common, functionally different variants Arg72Pro in p53 and Arg... DisGeNET Detail
Role of GSTM1 (Null/Present), GSTP1 (Ile105Val) and P53 (Arg72Pro) genetic polymorphisms and the ris... DisGeNET Detail
Association of p53 codon Arg72Pro and p73 G4C14-to-A4T14 at exon 2 genetic polymorphisms with the ri... DisGeNET Detail
Association of the germline TP53 R72P and MDM2 SNP309 variants with breast cancer survival in specif... DisGeNET Detail
Cox regression analysis showed p53 Arg72Pro heterozygous genotype was overall an independent prognos... DisGeNET Detail
MDM2 SNP309 and TP53 R72P associated with severe and febrile neutropenia in breast cancer patients t... DisGeNET Detail
The relationship of TP53 R72P polymorphism to disease outcome and TP53 mutation in myelodysplastic s... DisGeNET Detail
Genetic polymorphisms of p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro and the risk of cervical canc... DisGeNET Detail
TP53 Pro47Ser and Arg72Pro polymorphisms and colorectal cancer predisposition in an ethnic Kashmiri ... DisGeNET Detail
The G13964C intronic variant was significantly associated with familial breast cancer risk (p=0.0018... DisGeNET Detail
We have previously reported that the common, functionally different variants Arg72Pro in p53 and Arg... DisGeNET Detail
An SNP, Arg72Pro, of the TP53 gene encoding a DNA damage response protein showed the strongest assoc... DisGeNET Detail
To explore the role of polymorphisms of p53-related genes in etiology of oral cancer, we investigate... DisGeNET Detail
The p53 R72P polymorphism does not influence cervical cancer development in a Portuguese population:... DisGeNET Detail
Combining the two 'candidate' SNPs (P187S and R72P) revealed an increased risk for breast cancer of ... DisGeNET Detail
The results indicate protective associations of p53 Arg72Pro heterozygous variant with postmenopausa... DisGeNET Detail
Arg72Pro polymorphism of TP53 gene and the risk of skin cancer: a meta-analysis. DisGeNET Detail
Four of the variants were found to be weakly associated with lung cancer risk with borderline signif... DisGeNET Detail
The study provides evidence of the association of the TP53 gene polymorphisms Arg72Pro and PIN3 (+16... DisGeNET Detail
The functional TP53 rs1042522 and MDM4 rs4245739 genetic variants contribute to Non-Hodgkin lymphoma... DisGeNET Detail
Recently a polymorphism at codon 72 (R72P) in the tumour suppressor gene TP53 has been implicated in... DisGeNET Detail
[TP53 polymorphisms may affect both CIN3+ and persistent HPV infection. However, in our population p... DisGeNET Detail
Polymorphism of the p53 codon 72 Arg/Pro and the risk of HPV type 16/18-associated cervical and oral... DisGeNET Detail
Several studies have examined the prognostic value of the TP53 Arg72Pro polymorphism (rs1042522) and... DisGeNET Detail
Association of the germline TP53 R72P and MDM2 SNP309 variants with breast cancer survival in specif... DisGeNET Detail
Association of p53 codon Arg72Pro and p73 G4C14-to-A4T14 at exon 2 genetic polymorphisms with the ri... DisGeNET Detail
The Arg variant of p53 Arg72Pro is associated with progression of SIL to cervical cancer only in the... DisGeNET Detail
Polymorphisms of p53 Arg72Pro, p73 G4C14-to-A4T14 at exon 2 and p21 Ser31Arg and the risk of non-Hod... DisGeNET Detail
Two functional single nucleotide polymorphisms (SNPs), p53 R72P and MDM2 SNP309, are associated with... DisGeNET Detail
Four of the variants were found to be weakly associated with lung cancer risk with borderline signif... DisGeNET Detail
Association of p73 G4C14-to-A4T14 polymorphism at exon 2 and p53 Arg72Pro polymorphism with the risk... DisGeNET Detail
TP53 Arg72Pro polymorphism in Turkish patients with sporadic amyotrophic lateral sclerosis. DisGeNET Detail
Association of p53 Arg72Pro polymorphism with esophageal cancer: a meta-analysis based on 14 case-co... DisGeNET Detail
In conclusion SNPs in WRAP53 (rs2287497 and rs2287498) have stronger association with an ovarian can... DisGeNET Detail
Although we did not find a significant relationship between the frequency of the Arg/Pro + Pro/Pro g... DisGeNET Detail
We therefore investigated the combined effects of polymorphisms in TP53 (Arg72Pro) and p21/CDKN1A (S... DisGeNET Detail
We here studied the association of rs1219648 in FGFR2 and rs1042522 in TP53 and their interaction in... DisGeNET Detail
Association of MDM2 SNP309 and TP53 Arg72Pro polymorphisms with risk of endometrial cancer. DisGeNET Detail
In this study, we analyzed the association of TP53 Pro72Arg polymorphism with squamous cell carcinom... DisGeNET Detail
We aimed to investigate the association between miR-34b/c rs4938723 and TP53 Arg72Pro polymorphisms ... DisGeNET Detail
Association of MDM2 SNP309 and TP53 Arg72Pro polymorphisms with risk of endometrial cancer. DisGeNET Detail
Epistatic interaction of Arg72Pro TP53 and -710 C/T VEGFR1 polymorphisms in breast cancer: predispos... DisGeNET Detail
Quantitative assessment of the association between TP53 Arg72Pro polymorphism and risk of glioma. DisGeNET Detail
Association of MDM2 T309G and p53 Arg72Pro polymorphisms and gastroesophageal reflux disease with su... DisGeNET Detail
A case (n=250)-control (n=500) study was undertaken to investigate the role of Single Nucleotide Pol... DisGeNET Detail
The role of TP53 PRO47SER and ARG72PRO single nucleotide polymorphisms in the susceptibility to blad... DisGeNET Detail
The effects of p53 Arg72Pro polymorphism on glioma susceptibility: a meta-analysis. DisGeNET Detail
Among the five TP53 polymorphisms investigated, only p.R72P polymorphism may contributes to EC susce... DisGeNET Detail
We conducted a case-control study in order to investigate the association of RAD51 135G&gt;C and TP5... DisGeNET Detail
Association of p53 Arg72Pro polymorphism with esophageal cancer: a meta-analysis based on 14 case-co... DisGeNET Detail
The TP53 gene polymorphisms, Arg72Pro and PIN3 (+16 bp), can have prognostic and predictive value in... DisGeNET Detail
Studies of the association of Arg72Pro of tumor suppressor protein p53 with type 2 diabetes in a com... DisGeNET Detail
We performed a case-control association study to evaluate the association between common polymorphis... DisGeNET Detail
The p53 Arg72Pro and MDM2 -309 polymorphisms and risk of breast cancer in the nurses' health studies... DisGeNET Detail
We have previously reported that the common, functionally different variants Arg72Pro in p53 and Arg... DisGeNET Detail
In case-only analysis, the homozygous p73 G4C14-to-A4T14 variant of p73 genotype was associated with... DisGeNET Detail
In conclusion SNPs in WRAP53 (rs2287497 and rs2287498) have stronger association with an ovarian can... DisGeNET Detail
A case (n=250)-control (n=500) study was undertaken to investigate the role of Single Nucleotide Pol... DisGeNET Detail
Present report evaluated the association of polymorphism in exon 4 Arg72Pro (G&gt;C) of the p53 gene... DisGeNET Detail
In a large prospective cohort, p53 Arg72Pro Pro/Pro was associated with a 2-fold increased risk of d... DisGeNET Detail
In conclusions, p53 Arg72Pro polymorphism is a potential marker of HP infection-related HNSCC rather... DisGeNET Detail
Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105Val) polymorphisms i... DisGeNET Detail
This meta-analysis suggests that Pro allele in P53 Arg72Pro is significantly associated with the inc... DisGeNET Detail
Four of the variants were found to be weakly associated with lung cancer risk with borderline signif... DisGeNET Detail
Therefore, we hypothesized that the genetic variants in these three genes influence the predispositi... DisGeNET Detail
Association of p53 Arg72Pro polymorphism with gastric cancer: a meta-analysis. DisGeNET Detail
[TP53 genetic polymorphisms and environmental risk factors associated with cervical carcinogenesis i... DisGeNET Detail
Genetic polymorphisms of p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro and the risk of cervical canc... DisGeNET Detail
Association of MDM2 SNP309 and TP53 Arg72Pro polymorphisms with risk of endometrial cancer. DisGeNET Detail
TP53 Arg72Pro polymorphism and endometrial cancer risk: a meta-analysis. DisGeNET Detail
Polymorphisms of p53 Arg72Pro, p73 G4C14-to-A4T14 at exon 2 and p21 Ser31Arg and the risk of non-Hod... DisGeNET Detail
These results suggest that p53 Arg72Pro polymorphism, but not GSTP1 Ile105Val, may contribute to eso... DisGeNET Detail
Several studies have investigated the association between TP53 Arg72Pro and an increased risk of dev... DisGeNET Detail
We evaluated the effect of MDM2 SNP309 and its interaction with the p53 Arg72Pro polymorphism on pig... DisGeNET Detail
Role of GSTM1 (Null/Present), GSTP1 (Ile105Val) and P53 (Arg72Pro) genetic polymorphisms and the ris... DisGeNET Detail
This study provides evidence supporting the association of p53 SNP Arg72Pro with GC with invasive ph... DisGeNET Detail
Stratification analyses showed that a reduced risk associated with the -606CC genotype was more pron... DisGeNET Detail
MDM2 SNP309 and TP53 R72P are significantly associated with severe neutropenia and FN, respectively,... DisGeNET Detail
Impact of the MDM2 SNP309 and p53 Arg72Pro polymorphism on age of tumour onset in Li-Fraumeni syndro... DisGeNET Detail
Association of p73 G4C14-to-A4T14 polymorphism at exon 2 and p53 Arg72Pro polymorphism with the risk... DisGeNET Detail
An evaluation of the polymorphisms Ins16bp and Arg72Pro in p53 as breast cancer risk modifiers in BR... DisGeNET Detail
Individual and combined effects of MDM2 SNP309 and TP53 Arg72Pro on breast cancer risk: an updated m... DisGeNET Detail
Association of p53 Arg72Pro polymorphism with bladder cancer: a meta-analysis. DisGeNET Detail
We evaluated the effect of MDM2 SNP309 and its interaction with the p53 Arg72Pro polymorphism on pig... DisGeNET Detail
Association of p53 Arg72Pro polymorphism with bladder cancer: a meta-analysis. DisGeNET Detail
RAD51 135G&gt;C and TP53 Arg72Pro polymorphisms and susceptibility to breast cancer in Serbian women... DisGeNET Detail
R72P polymorphism of TP53 in ulcerative colitis patients is associated with the incidence of colecto... DisGeNET Detail
The functional TP53 rs1042522 and MDM4 rs4245739 genetic variants contribute to Non-Hodgkin lymphoma... DisGeNET Detail
Association between TP53 Arg72Pro polymorphism and hepatocellular carcinoma risk: a meta-analysis. DisGeNET Detail
Several studies have examined the prognostic value of the TP53 Arg72Pro polymorphism (rs1042522) and... DisGeNET Detail
The SNP rs4938723 and diabetes mellitus (DM) together were associated with an increased CRC risk, bu... DisGeNET Detail
Meta-analysis shows significant association of the TP53 Arg72Pro with ovarian cancer risk. DisGeNET Detail
Individual and combined effects of MDM2 SNP309 and TP53 Arg72Pro on breast cancer risk: an updated m... DisGeNET Detail
Clinical implications of the MDM2 SNP309 and p53 Arg72Pro polymorphisms in transitional cell carcino... DisGeNET Detail
To evaluate the role of genetic P53 polymorphism in RP, we analyzed the P53 Arg72Pro polymorphism in... DisGeNET Detail
Association of p53 codon Arg72Pro and p73 G4C14-to-A4T14 at exon 2 genetic polymorphisms with the ri... DisGeNET Detail
Genetic polymorphisms in the 3'UTR region of the CXCL12 (rs1801157) and TP53 codon 72 (rs1042522) ge... DisGeNET Detail
We searched multiple databases (through March 8, 2011) for studies investigating the association of ... DisGeNET Detail
We conducted a case-control study in order to investigate the association of RAD51 135G&gt;C and TP5... DisGeNET Detail
We evaluated seven single-nucleotide polymorphisms of six genes CDA Lys27Gln (A/C); CDA C435T; ERCC1... DisGeNET Detail
TP53 Arg72Pro polymorphism and endometrial cancer risk: a meta-analysis. DisGeNET Detail
To explore the role of polymorphisms of p53-related genes in etiology of oral cancer, we investigate... DisGeNET Detail
Genetic polymorphisms of p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro and the risk of cervical canc... DisGeNET Detail
TP53 Arg72Pro polymorphism is associated with esophageal cancer risk: a meta-analysis. DisGeNET Detail
Association between p53 codon 72 (Arg72Pro) polymorphism and primary open-angle glaucoma in Iranian ... DisGeNET Detail
These findings indicate that the SNPs in P53BP1 and p53 jointly contribute to breast cancer risk, pa... DisGeNET Detail
Genetic polymorphisms of p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro and the risk of cervical canc... DisGeNET Detail
Thus, MDM2 SNP 309 and p53 Arg72Pro are associated with the early development of HCC in Korean patie... DisGeNET Detail
MDM2 SNP309 and TP53 R72P associated with severe and febrile neutropenia in breast cancer patients t... DisGeNET Detail
The results of present study indicated that among the five TP53 polymorphisms investigated, the p.R7... DisGeNET Detail
Genotype misclassification in genetic association studies of the rs1042522 TP53 (Arg72Pro) polymorph... DisGeNET Detail
Subgroup analyses by source of controls and hepatitis virus infection status further demonstrated th... DisGeNET Detail
[TP53 polymorphisms may affect both CIN3+ and persistent HPV infection. However, in our population p... DisGeNET Detail
The p53 R72P polymorphism has been suggested to play a role in many cancers, including breast cancer... DisGeNET Detail
Association between XRCC1 ARG399GLN and P53 ARG72PRO polymorphisms and the risk of gastric and color... DisGeNET Detail
These results suggest that p53 Arg72Pro polymorphism, but not GSTP1 Ile105Val, may contribute to eso... DisGeNET Detail
When all 11 studies were pooled into the analysis, an increased esophageal cancer risk was significa... DisGeNET Detail
TP53 R72P and MDM2 SNP309 polymorphisms and colorectal cancer risk: the Fukuoka Colorectal Cancer St... DisGeNET Detail
Rare WDR36 variants and the P53 p.R72P polymorphism behaved as moderate glaucoma risk factors in Spa... DisGeNET Detail
We failed to confirm earlier reports of increased cervical cancer susceptibility in women who harbor... DisGeNET Detail
Pro variant of TP53 Arg72Pro contributes to esophageal squamous cell carcinoma risk: evidence from a... DisGeNET Detail
We investigated p53 codon 72 polymorphism (Arg72Pro) frequencies with respect to the susceptibility ... DisGeNET Detail
Association between p53 Arg72Pro polymorphism and thyroid cancer risk: a meta-analysis. DisGeNET Detail
TP53 single nucleotide polymorphism rs1042522 in salivary gland neoplasms. DisGeNET Detail
A case (n=250)-control (n=500) study was undertaken to investigate the role of Single Nucleotide Pol... DisGeNET Detail
Four of the variants were found to be weakly associated with lung cancer risk with borderline signif... DisGeNET Detail
The results suggested that the Arg399Gln polymorphism of XRCC1 gene, the 1G/2G polymorphism of MMP-1... DisGeNET Detail
RAD51 135G&gt;C and TP53 Arg72Pro polymorphisms and susceptibility to breast cancer in Serbian women... DisGeNET Detail
Stratification analyses showed that a reduced risk associated with the -606CC genotype was more pron... DisGeNET Detail
Meta-analysis of association between TP53 Arg72Pro polymorphism and bladder cancer risk. DisGeNET Detail
The gene-gene interaction between TP53 Arg72Pro and MDM2 T309G may interact in carcinogenesis of CRC... DisGeNET Detail
When all 11 studies were pooled into the analysis, an increased esophageal cancer risk was significa... DisGeNET Detail
Specifically, 2 polymorphisms-an arginine-to-glutamine substitution at codon 399 (Q399R) in XRCC1 an... DisGeNET Detail
Investigation of the effect of MDM2 SNP309 and TP53 Arg72Pro polymorphisms on the age of onset of cu... DisGeNET Detail
These findings indicate that the SNPs in P53BP1 and p53 jointly contribute to breast cancer risk, pa... DisGeNET Detail
Combined effects of MDM2 SNP309 and TP53 R72P polymorphisms, and soy isoflavones on breast cancer ri... DisGeNET Detail
The results indicated that the polymorphism in TP53 (rs1042522) might be associated with risk of cer... DisGeNET Detail
Combining the two 'candidate' SNPs (P187S and R72P) revealed an increased risk for breast cancer of ... DisGeNET Detail
Association of p53 Arg72Pro polymorphism with gastric cancer: a meta-analysis. DisGeNET Detail
Using SNP- and gene-based analysis methods, we replicated previously reported SNP-type 2 diabetes as... DisGeNET Detail
Polymorphism of p53 gene codon72 arginine (Arg)/proline (Pro) (rs1042522) may influence the function... DisGeNET Detail
Association between TP53 Arg72Pro polymorphism and thyroid carcinoma risk. DisGeNET Detail
Previous studies have highlighted the contribution of the common functional polymorphisms p53 p.Arg7... DisGeNET Detail
The results suggested that the Arg399Gln polymorphism of XRCC1 gene, the 1G/2G polymorphism of MMP-1... DisGeNET Detail
We aimed to investigate the association between miR-34b/c rs4938723 and TP53 Arg72Pro polymorphisms ... DisGeNET Detail
Role of GSTM1 (Null/Present), GSTP1 (Ile105Val) and P53 (Arg72Pro) genetic polymorphisms and the ris... DisGeNET Detail
This study investigated whether the functional polymorphisms in P53 pathway genes, P53 Arg72Pro (rs1... DisGeNET Detail
Epistatic interaction of Arg72Pro TP53 and -710 C/T VEGFR1 polymorphisms in breast cancer: predispos... DisGeNET Detail
Our findings provide evidence that the TP53 Arg72Pro is associated with an increased risk of NHL in ... DisGeNET Detail
Although the p53 R72P SNPs and MDM2 SNP309 did not associate with any of the parameters studied, the... DisGeNET Detail
In case-only analysis, the homozygous p73 G4C14-to-A4T14 variant of p73 genotype was associated with... DisGeNET Detail
Association of p53 Arg72Pro polymorphism and beta-catenin accumulation in mycosis fungoides. DisGeNET Detail
The association between TP53 Arg72Pro polymorphism and lung cancer susceptibility: evidence from 30,... DisGeNET Detail
We used SSCP and DNA sequencing to assess and compare frequencies of R72P (TP53) and 5'UTR203G&gt;A,... DisGeNET Detail
Polymorphisms in TP53 (rs1042522), p16 (rs11515 and rs3088440) and NQO1 (rs1800566) genes in Thai ce... DisGeNET Detail
Lack of association between MDM2 SNP309 and TP53 Arg72Pro polymorphisms with clinical outcomes in my... DisGeNET Detail
Prognostic value of the TP53 Arg72Pro single-nucleotide polymorphism and susceptibility to medullobl... DisGeNET Detail
MDM2 SNP309 and p53 Arg72Pro in cutaneous melanoma: association between SNP309 GG genotype and tumor... DisGeNET Detail
Using SNP- and gene-based analysis methods, we replicated previously reported SNP-type 2 diabetes as... DisGeNET Detail
Association of MDM2 SNP309 and TP53 Arg72Pro polymorphisms with risk of endometrial cancer. DisGeNET Detail
The p53 codon 72 polymorphism (rs1042522) is associated with proliferative vitreoretinopathy: the Re... DisGeNET Detail
Polymorphisms in TP53 (rs1042522), p16 (rs11515 and rs3088440) and NQO1 (rs1800566) genes in Thai ce... DisGeNET Detail
BRCA2 methylation frequency was 44%, p53 Pro22 allele frequency was 32% and heterozygous frequency o... DisGeNET Detail
Involvement of p53 R72P polymorphism in the association of MDM2-SNP309 with breast cancer. DisGeNET Detail
TP53 Pro47Ser and Arg72Pro polymorphisms and colorectal cancer predisposition in an ethnic Kashmiri ... DisGeNET Detail
To explore the role of polymorphisms of p53-related genes in etiology of oral cancer, we investigate... DisGeNET Detail
A case (n=250)-control (n=500) study was undertaken to investigate the role of Single Nucleotide Pol... DisGeNET Detail
Our study suggests that the polymorphism of p53 codon 72 Arg/Pro may play a protective role in the d... DisGeNET Detail
The updated meta-analysis suggests that the p53 codon 72 Arg/Pro polymorphism is a risk factor for l... DisGeNET Detail
The results suggested that the Arg399Gln polymorphism of XRCC1 gene, the 1G/2G polymorphism of MMP-1... DisGeNET Detail
This meta-analysis suggests that Pro allele in P53 Arg72Pro is significantly associated with the inc... DisGeNET Detail
MDM2 SNP309 and TP53 Arg72Pro interact to alter therapy-related acute myeloid leukemia susceptibilit... DisGeNET Detail
Quantitative assessment of the association between TP53 Arg72Pro polymorphism and bladder cancer ris... DisGeNET Detail
Association of p73 G4C14-to-A4T14 polymorphism at exon 2 and p53 Arg72Pro polymorphism with the risk... DisGeNET Detail
An SNP, Arg72Pro, of the TP53 gene encoding a DNA damage response protein showed the strongest assoc... DisGeNET Detail
Among the five TP53 polymorphisms investigated, only p.R72P polymorphism may contributes to EC susce... DisGeNET Detail
[TP53 genetic polymorphisms and environmental risk factors associated with cervical carcinogenesis i... DisGeNET Detail
Combined effects of MDM2 SNP309 and TP53 R72P polymorphisms, and soy isoflavones on breast cancer ri... DisGeNET Detail
TP53 Arg72Pro polymorphism is associated with esophageal cancer risk: a meta-analysis. DisGeNET Detail
Age of diagnosis of colorectal cancer in HNPCC patients is more complex than that predicted by R72P ... DisGeNET Detail
An evaluation of the polymorphisms Ins16bp and Arg72Pro in p53 as breast cancer risk modifiers in BR... DisGeNET Detail
Polymorphism Arg72Pro of p53 confers susceptibility to squamous cell carcinoma of lungs in a North I... DisGeNET Detail
This study examined the effect of P53 Arg72Pro variants on transactivation of polymorphic MDM2 promo... DisGeNET Detail
The p53 Arg72Pro and MDM2 -309 polymorphisms and risk of breast cancer in the nurses' health studies... DisGeNET Detail
Association of p53 Arg72Pro and MDM2 SNP309 polymorphisms with glioma. DisGeNET Detail
Association of p53 codon Arg72Pro and p73 G4C14-to-A4T14 at exon 2 genetic polymorphisms with the ri... DisGeNET Detail
Association of p53 Arg72Pro and MDM2 SNP309 polymorphisms with glioma. DisGeNET Detail
The role of the TP53 gene's R72P polymorphism in non-Hodgkin lymphoma (NHL) has been analyzed in sev... DisGeNET Detail
To explore the role of polymorphisms of p53-related genes in etiology of oral cancer, we investigate... DisGeNET Detail
Genetic polymorphisms of p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro and the risk of cervical canc... DisGeNET Detail
Combined effects of MDM2 SNP309 and TP53 R72P polymorphisms, and soy isoflavones on breast cancer ri... DisGeNET Detail
These data do not support an association between the p53 Arg72Pro polymorphism and bladder cancer. DisGeNET Detail
Association between TP53 gene ARG72PRO polymorphism and chromosome aberrations in human cancers. DisGeNET Detail
The significance of MDM2 SNP309 and p53 Arg72Pro in young women with breast cancer. DisGeNET Detail
The TP53 Arg72Pro polymorphism and lung cancer risk in a population of Northern Spain. DisGeNET Detail
Although the p53 R72P SNPs and MDM2 SNP309 did not associate with any of the parameters studied, the... DisGeNET Detail
Lack of association of the TP53 Arg72Pro SNP and the MDM2 SNP309 with systemic lupus erythematosus i... DisGeNET Detail
Loss of heterozygosity and p53 polymorphism Pro72Arg in a young patient with medulloblastoma. DisGeNET Detail
We investigated the distribution of the p53 Arg72Pro (rs1042522) and MDM2 SNP309 (rs2279744) genotyp... DisGeNET Detail
Effect of TP53 Arg72Pro and MDM2 SNP309 polymorphisms on the risk of high-grade osteosarcoma develop... DisGeNET Detail
Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105Val) polymorphisms i... DisGeNET Detail
TP53 Arg72Pro polymorphism is associated with esophageal cancer risk: a meta-analysis. DisGeNET Detail
Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large pooled series from th... DisGeNET Detail
MDM2 SNP309 and TP53 Arg72Pro interact to alter therapy-related acute myeloid leukemia susceptibilit... DisGeNET Detail
MDM2 SNP309 and TP53 R72P associated with severe and febrile neutropenia in breast cancer patients t... DisGeNET Detail
The TP53 Arg72Pro polymorphism and lung cancer risk in a population of Northern Spain. DisGeNET Detail
Rare WDR36 variants and the P53 p.R72P polymorphism behaved as moderate glaucoma risk factors in Spa... DisGeNET Detail
Epistatic interaction of Arg72Pro TP53 and -710 C/T VEGFR1 polymorphisms in breast cancer: predispos... DisGeNET Detail
TP53 Arg72Pro polymorphism and colorectal cancer risk: a systematic review and meta-analysis. DisGeNET Detail
Pairwise analysis showed that combinations of the ERalpha G allele with the homozygous Trp genotype ... DisGeNET Detail
Association of p73 G4C14-to-A4T14 polymorphism at exon 2 and p53 Arg72Pro polymorphism with the risk... DisGeNET Detail
MDM2 SNP309 and p53 Arg72Pro in cutaneous melanoma: association between SNP309 GG genotype and tumor... DisGeNET Detail
These results suggest that p53 Arg72Pro polymorphism, but not GSTP1 Ile105Val, may contribute to eso... DisGeNET Detail
The present study was undertaken to investigate the association of p53 Arg72Pro, Ins16bp and G13964C... DisGeNET Detail
However, no overall association was found between the TP53 Arg72Pro polymorphism and gastric cancer ... DisGeNET Detail
Using SNP- and gene-based analysis methods, we replicated previously reported SNP-type 2 diabetes as... DisGeNET Detail
To explore the role of polymorphisms of p53-related genes in etiology of oral cancer, we investigate... DisGeNET Detail
Impact of the MDM2 SNP309 and p53 Arg72Pro polymorphism on age of tumour onset in Li-Fraumeni syndro... DisGeNET Detail
Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large pooled series from th... DisGeNET Detail
Genotype misclassification in genetic association studies of the rs1042522 TP53 (Arg72Pro) polymorph... DisGeNET Detail
We genotyped 4 single nucleotide polymorphisms (SNPs) with amino acid changes, TP53 Pro72Arg (rs1042... DisGeNET Detail
MDM2 SNP309 and TP53 R72P associated with severe and febrile neutropenia in breast cancer patients t... DisGeNET Detail
In a large prospective cohort, p53 Arg72Pro Pro/Pro was associated with a 2-fold increased risk of d... DisGeNET Detail
Functional MDM4 rs4245739 genetic variant, alone and in combination with P53 Arg72Pro polymorphism, ... DisGeNET Detail
In the analyses of ATM/TP53 (rs1801516/rs664677/rs609429/rs1042522) combinations, the GG/TC/CG/GC ge... DisGeNET Detail
Studies of the association of Arg72Pro of tumor suppressor protein p53 with type 2 diabetes in a com... DisGeNET Detail
To explore the role of polymorphisms of p53-related genes in etiology of oral cancer, we investigate... DisGeNET Detail
Subgroup analyses by source of controls and hepatitis virus infection status further demonstrated th... DisGeNET Detail
Lack of influence of TP53 Arg72Pro and 16bp duplication polymorphisms on risk of breast cancer in Ir... DisGeNET Detail
An evaluation of the polymorphisms Ins16bp and Arg72Pro in p53 as breast cancer risk modifiers in BR... DisGeNET Detail
Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105Val) polymorphisms i... DisGeNET Detail
Updated meta-analysis of the TP53 Arg72Pro polymorphism and gastric cancer risk. DisGeNET Detail
Convergent evidence of the contribution of TP53 genetic variation (Pro72Arg) to metabolic activity a... DisGeNET Detail
Association between p53 Arg72Pro polymorphism and the risk of human papillomavirus-related head and ... DisGeNET Detail
An evaluation of the polymorphisms Ins16bp and Arg72Pro in p53 as breast cancer risk modifiers in BR... DisGeNET Detail
RAD51 135G&gt;C and TP53 Arg72Pro polymorphisms and susceptibility to breast cancer in Serbian women... DisGeNET Detail
Among the five TP53 polymorphisms investigated, only p.R72P polymorphism may contributes to EC susce... DisGeNET Detail
Elevated risk of squamous-cell carcinoma of the lung in heavy smokers carrying the variant alleles o... DisGeNET Detail
Association between p53 Arg72Pro polymorphism and colorectal cancer risk: a meta-analysis. DisGeNET Detail
Association of MDM2 SNP309 and TP53 Arg72Pro polymorphisms with risk of endometrial cancer. DisGeNET Detail
Though rs1042522 and rs8064946 did not show positive association with schizophrenia, we did observe ... DisGeNET Detail
Pairwise analysis showed that combinations of the ERalpha G allele with the homozygous Trp genotype ... DisGeNET Detail
Association of p73 G4C14-to-A4T14 polymorphism at exon 2 and p53 Arg72Pro polymorphism with the risk... DisGeNET Detail
No significant association between p53 codon 72 Arg/Pro polymorphism and risk of oral cancer. DisGeNET Detail
These findings indicate that the SNPs in P53BP1 and p53 jointly contribute to breast cancer risk, pa... DisGeNET Detail
The p53 R72P polymorphism has been suggested to play a role in many cancers, including breast cancer... DisGeNET Detail
Association of p73 G4C14-to-A4T14 polymorphism at exon 2 and p53 Arg72Pro polymorphism with the risk... DisGeNET Detail
Association of rheumatoid arthritis with Mdm2 SNP309 and genetic evidence for an allele-specific int... DisGeNET Detail
Effect of the codon 72 polymorphism (c.215G&gt;C, p.Arg72Pro) in combination with somatic sequence v... DisGeNET Detail
In addition to TP53 gene mutations, a common polymorphism, Arg72Pro, has been involved in the carcin... DisGeNET Detail
The present study was undertaken to investigate the association of p53 Arg72Pro, Ins16bp and G13964C... DisGeNET Detail
TP53 R72P and MDM2 SNP309 polymorphisms and colorectal cancer risk: the Fukuoka Colorectal Cancer St... DisGeNET Detail
Aiming to study the role of TP53 Pro47Ser and Arg72Pro on glioma susceptibility and oncologic progno... DisGeNET Detail
MDM2 SNP309 and TP53 R72P are significantly associated with severe neutropenia and FN, respectively,... DisGeNET Detail
MDM2 rs2279744 and TP53 rs1042522 polymorphisms associated with etoposide- and cisplatin-induced gra... DisGeNET Detail
These data do not support an association between the p53 Arg72Pro polymorphism and bladder cancer. DisGeNET Detail
Detection of human papillomavirus (HPV) DNA prevalence and p53 codon 72 (Arg72Pro) polymorphism in p... DisGeNET Detail
Effect of the codon 72 polymorphism (c.215G&gt;C, p.Arg72Pro) in combination with somatic sequence v... DisGeNET Detail
Role of TP53 Arg72Pro polymorphism in urinary bladder cancer predisposition and predictive impact of... DisGeNET Detail
Age of diagnosis of CRC in HNPCC patients is therefore more complex than that predicted by the R72P ... DisGeNET Detail
Through searching PubMed databases (or hand searching) up to April 2012 using the following MeSH ter... DisGeNET Detail
Association of p73 G4C14-to-A4T14 polymorphism at exon 2 and p53 Arg72Pro polymorphism with the risk... DisGeNET Detail
Stratification analyses showed that a reduced risk associated with the -606CC genotype was more pron... DisGeNET Detail
The association between TP53 Arg72Pro polymorphism and lung cancer susceptibility: evidence from 30,... DisGeNET Detail
An evaluation of the polymorphisms Ins16bp and Arg72Pro in p53 as breast cancer risk modifiers in BR... DisGeNET Detail
We evaluated the effect of MDM2 SNP309 and its interaction with the p53 Arg72Pro polymorphism on pig... DisGeNET Detail
However, we did not find any main effect of TP53 Arg72Pro on HCC risk in this population. DisGeNET Detail
Lack of influence of TP53 Arg72Pro and 16bp duplication polymorphisms on risk of breast cancer in Ir... DisGeNET Detail
The functional MDM2 T309G genetic variant but not P53 Arg72Pro polymorphism is associated with risk ... DisGeNET Detail
In subgroup analyses based on pathological type, the Pro variant was significantly associated with a... DisGeNET Detail
We evaluated seven single-nucleotide polymorphisms of six genes CDA Lys27Gln (A/C); CDA C435T; ERCC1... DisGeNET Detail
Pro variant of TP53 Arg72Pro contributes to gastric cancer risk in Asians: evidence from a meta-anal... DisGeNET Detail
We investigated the effects of the germ-line single nucleotide polymorphisms TP53 R72P (215G&gt;C) a... DisGeNET Detail
The R72P P53 mutation is associated with familial breast cancer in Jewish women. DisGeNET Detail
TP53 R72P and MDM2 SNP309 polymorphisms in modification of childhood acute lymphoblastic leukemia su... DisGeNET Detail
TGFbeta1 (Leu10Pro), p53 (Arg72Pro) can predict for increased risk for breast cancer in south Indian... DisGeNET Detail
MDM2 rs2279744 and TP53 rs1042522 SNPs were associated with EP-induced high-grade neutropenia in ext... DisGeNET Detail
Effect of TP53 Arg72Pro and MDM2 SNP309 polymorphisms on the risk of high-grade osteosarcoma develop... DisGeNET Detail
Our results suggest a possible association between P53 Arg72Pro polymorphisms and susceptibility to ... DisGeNET Detail
TP53 Arg72Pro polymorphism and endometrial cancer risk: a meta-analysis. DisGeNET Detail
Although we did not find a significant relationship between the frequency of the Arg/Pro + Pro/Pro g... DisGeNET Detail
Role of TP53 Arg72Pro polymorphism in urinary bladder cancer predisposition and predictive impact of... DisGeNET Detail
A case (n=250)-control (n=500) study was undertaken to investigate the role of Single Nucleotide Pol... DisGeNET Detail
Genetic polymorphisms in the 3'UTR region of the CXCL12 (rs1801157) and TP53 codon 72 (rs1042522) ge... DisGeNET Detail
Interaction of P53 Arg72Pro and MDM2 T309G polymorphisms and their associations with risk of gastric... DisGeNET Detail
TP53 R72P and MDM2 SNP309 polymorphisms in modification of childhood acute lymphoblastic leukemia su... DisGeNET Detail
Effect of TP53 Arg72Pro and MDM2 SNP309 polymorphisms on the risk of high-grade osteosarcoma develop... DisGeNET Detail
Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105Val) polymorphisms i... DisGeNET Detail
We have previously reported that the common, functionally different variants Arg72Pro in p53 and Arg... DisGeNET Detail
Through searching PubMed databases (or hand searching) up to April 2012 using the following MeSH ter... DisGeNET Detail
Modeling gene-environment interactions in oral cavity and esophageal cancers demonstrates a role for... DisGeNET Detail
TP53 Arg72Pro polymorphism and lung cancer risk: a meta-analysis. DisGeNET Detail
This study investigated the influence of combined p53 Arg72Pro and MDM2 SNP309 on the risk of develo... DisGeNET Detail
We evaluated seven single-nucleotide polymorphisms of six genes CDA Lys27Gln (A/C); CDA C435T; ERCC1... DisGeNET Detail
Studies of the association of Arg72Pro of tumor suppressor protein p53 with type 2 diabetes in a com... DisGeNET Detail
Therefore, we hypothesized that the genetic variants in these three genes influence the predispositi... DisGeNET Detail
Association of p53 genetic polymorphism (Arg72Pro) with estrogen receptor positive breast cancer ris... DisGeNET Detail
Therefore, we hypothesized that the genetic variants in these three genes influence the predispositi... DisGeNET Detail
Our data indicate that the TP53 Arg72Pro polymorphism increases the risk for squamous-cell carcinoma... DisGeNET Detail
Epistatic interaction of Arg72Pro TP53 and -710 C/T VEGFR1 polymorphisms in breast cancer: predispos... DisGeNET Detail
This meta-analysis indicates that the p53 Arg72Pro polymorphism may contribute to susceptibility to ... DisGeNET Detail
Using SNP- and gene-based analysis methods, we replicated previously reported SNP-type 2 diabetes as... DisGeNET Detail
Because our results suggest for the first time that the Pro/Pro homozygote of p53 Arg72Pro polymorph... DisGeNET Detail
The results indicated that the polymorphism in TP53 (rs1042522) might be associated with risk of cer... DisGeNET Detail
MDM2 rs2279744 and TP53 rs1042522 polymorphisms associated with etoposide- and cisplatin-induced gra... DisGeNET Detail
Present report evaluated the association of polymorphism in exon 4 Arg72Pro (G&gt;C) of the p53 gene... DisGeNET Detail
The p53 Arg72Pro and MDM2 -309 polymorphisms and risk of breast cancer in the nurses' health studies... DisGeNET Detail
Using SNP- and gene-based analysis methods, we replicated previously reported SNP-type 2 diabetes as... DisGeNET Detail
Association between p53 Arg72Pro polymorphism and colorectal cancer risk: a meta-analysis. DisGeNET Detail
Four of the variants were found to be weakly associated with lung cancer risk with borderline signif... DisGeNET Detail
Interaction of P53 Arg72Pro and MDM2 T309G polymorphisms and their associations with risk of gastric... DisGeNET Detail
Updated meta-analysis of the TP53 Arg72Pro polymorphism and gastric cancer risk. DisGeNET Detail
The updated meta-analysis suggests that the p53 codon 72 Arg/Pro polymorphism is a risk factor for l... DisGeNET Detail
Lack of evidence that p53 Arg72Pro influences lung cancer prognosis: an analysis of survival in 619 ... DisGeNET Detail
Combined effects of MDM2 SNP309 and TP53 R72P polymorphisms, and soy isoflavones on breast cancer ri... DisGeNET Detail
Genetic polymorphisms in the 3'UTR region of the CXCL12 (rs1801157) and TP53 codon 72 (rs1042522) ge... DisGeNET Detail
Role of GSTM1 (Null/Present), GSTP1 (Ile105Val) and P53 (Arg72Pro) genetic polymorphisms and the ris... DisGeNET Detail
Meta-analysis shows significant association of the TP53 Arg72Pro with ovarian cancer risk. DisGeNET Detail
Individual and combined effects of MDM2 SNP309 and TP53 Arg72Pro on breast cancer risk: an updated m... DisGeNET Detail
TP53 R72P and MDM2 SNP309 polymorphisms and colorectal cancer risk: the Fukuoka Colorectal Cancer St... DisGeNET Detail
Few reports have investigated the association of two p53 polymorphisms (Arg72Pro and PIN3-A2) with c... DisGeNET Detail
The results suggested that the Arg399Gln polymorphism of XRCC1 gene, the 1G/2G polymorphism of MMP-1... DisGeNET Detail
In the analyses of ATM/TP53 (rs1801516/rs664677/rs609429/rs1042522) combinations, the GG/TC/CG/GC ge... DisGeNET Detail
In addition, the Arg72Pro genotype of 116 breast tumors was determined, and correlated with intratum... DisGeNET Detail
The significance of MDM2 SNP309 and p53 Arg72Pro in young women with breast cancer. DisGeNET Detail
This meta-analysis suggests that Pro allele in P53 Arg72Pro is significantly associated with the inc... DisGeNET Detail
Functional MDM4 rs4245739 genetic variant, alone and in combination with P53 Arg72Pro polymorphism, ... DisGeNET Detail
MDM2 SNP309 and p53 Arg72Pro in cutaneous melanoma: association between SNP309 GG genotype and tumor... DisGeNET Detail
Quantitative assessment of the association between TP53 Arg72Pro polymorphism and bladder cancer ris... DisGeNET Detail
Few reports have investigated the association of two p53 polymorphisms (Arg72Pro and PIN3-A2) with c... DisGeNET Detail
A case (n=250)-control (n=500) study was undertaken to investigate the role of Single Nucleotide Pol... DisGeNET Detail
The relationship of p53 codon 72 Arg/Pro polymorphism with the susceptibility to glioma needs furthe... DisGeNET Detail
We conducted a case-control study in order to investigate the association of RAD51 135G&gt;C and TP5... DisGeNET Detail
These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and the Pro allele of TP5... DisGeNET Detail
The relationship of TP53 R72P polymorphism to disease outcome and TP53 mutation in myelodysplastic s... DisGeNET Detail
Investigation of the effect of MDM2 SNP309 and TP53 Arg72Pro polymorphisms on the age of onset of cu... DisGeNET Detail
Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large pooled series from th... DisGeNET Detail
To examine whether TP53 polymorphisms may be involved with in vitro fertilization (IVF) failure and ... DisGeNET Detail
Meta-analysis of association between TP53 Arg72Pro polymorphism and bladder cancer risk. DisGeNET Detail
Association of the germline TP53 R72P and MDM2 SNP309 variants with breast cancer survival in specif... DisGeNET Detail
We performed a case-control association study to evaluate the association between common polymorphis... DisGeNET Detail
Functional MDM4 rs4245739 genetic variant, alone and in combination with P53 Arg72Pro polymorphism, ... DisGeNET Detail
Using SNP- and gene-based analysis methods, we replicated previously reported SNP-type 2 diabetes as... DisGeNET Detail
Association of p53 Arg72Pro polymorphism with esophageal cancer: a meta-analysis based on 14 case-co... DisGeNET Detail
The results of present study indicated that among the five TP53 polymorphisms investigated, the p.R7... DisGeNET Detail
MDM2 rs2279744 and TP53 rs1042522 polymorphisms associated with etoposide- and cisplatin-induced gra... DisGeNET Detail
We pooled data from four breast cancer cohorts within the Breast Cancer Association Consortium for w... DisGeNET Detail
Association between the p53 codon 72 Arg/Pro polymorphism and hepatocellular carcinoma risk. DisGeNET Detail
Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large pooled series from th... DisGeNET Detail
TP53 R72P polymorphism modulates DNA methylation in hepatocellular carcinoma. DisGeNET Detail
We investigated the effects of the germ-line single nucleotide polymorphisms TP53 R72P (215G&gt;C) a... DisGeNET Detail
Association of the germline TP53 R72P and MDM2 SNP309 variants with breast cancer survival in specif... DisGeNET Detail
Thus, MDM2 SNP 309 and p53 Arg72Pro are associated with the early development of HCC in Korean patie... DisGeNET Detail
Role of GSTM1 (Null/Present), GSTP1 (Ile105Val) and P53 (Arg72Pro) genetic polymorphisms and the ris... DisGeNET Detail
However, no overall association was found between the TP53 Arg72Pro polymorphism and gastric cancer ... DisGeNET Detail
This study examined the effect of P53 Arg72Pro variants on transactivation of polymorphic MDM2 promo... DisGeNET Detail
Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105Val) polymorphisms i... DisGeNET Detail
Association of p53 genetic polymorphism (Arg72Pro) with estrogen receptor positive breast cancer ris... DisGeNET Detail
Haplotype analysis of p53 polymorphisms: Arg72Pro, Ins16bp and G13964C in Tunisian patients with fam... DisGeNET Detail
Aiming to study the role of TP53 Pro47Ser and Arg72Pro on glioma susceptibility and oncologic progno... DisGeNET Detail
An evaluation of the polymorphisms Ins16bp and Arg72Pro in p53 as breast cancer risk modifiers in BR... DisGeNET Detail
Pairwise analysis showed that combinations of the ERalpha G allele with the homozygous Trp genotype ... DisGeNET Detail
We searched multiple databases (through March 8, 2011) for studies investigating the association of ... DisGeNET Detail
The results suggested that the Arg399Gln polymorphism of XRCC1 gene, the 1G/2G polymorphism of MMP-1... DisGeNET Detail
Age at onset of Huntington disease is not modulated by the R72P variation in TP53 and the R196K vari... DisGeNET Detail
The results of our study suggest that combined analysis of TP53 polymorphisms Arg72Pro and 16-bp Ins... DisGeNET Detail
RAD51 135G&gt;C and TP53 Arg72Pro polymorphisms and susceptibility to breast cancer in Serbian women... DisGeNET Detail
Investigation of the effect of MDM2 SNP309 and TP53 Arg72Pro polymorphisms on the age of onset of cu... DisGeNET Detail
Postchemotherapy response analysis revealed that AML patients heterozygous for ATM 4138C&gt;T (rs309... DisGeNET Detail
Polymorphism of the p53 codon 72 Arg/Pro and the risk of HPV type 16/18-associated cervical and oral... DisGeNET Detail
Association of p53 genetic polymorphism (Arg72Pro) with estrogen receptor positive breast cancer ris... DisGeNET Detail
Association of p53 genetic polymorphism (Arg72Pro) with estrogen receptor positive breast cancer ris... DisGeNET Detail
We have previously reported that the common, functionally different variants Arg72Pro in p53 and Arg... DisGeNET Detail
Association of Arg72Pro of P53 polymorphism with colorectal cancer susceptibility risk in Malaysian ... DisGeNET Detail
A case (n=250)-control (n=500) study was undertaken to investigate the role of Single Nucleotide Pol... DisGeNET Detail
The role of TP53 PRO47SER and ARG72PRO single nucleotide polymorphisms in the susceptibility to blad... DisGeNET Detail
MDM2 rs2279744 and TP53 rs1042522 polymorphisms associated with etoposide- and cisplatin-induced gra... DisGeNET Detail
Association of p73 G4C14-to-A4T14 polymorphism at exon 2 and p53 Arg72Pro polymorphism with the risk... DisGeNET Detail
To explore the role of polymorphisms of p53-related genes in etiology of oral cancer, we investigate... DisGeNET Detail
Association of Arg72Pro of P53 polymorphism with colorectal cancer susceptibility risk in Malaysian ... DisGeNET Detail
Two functional single nucleotide polymorphisms (SNPs), p53 R72P and MDM2 SNP309, are associated with... DisGeNET Detail
TP53 R72P and MDM2 SNP309 polymorphisms and colorectal cancer risk: the Fukuoka Colorectal Cancer St... DisGeNET Detail
No significant association between p53 codon 72 Arg/Pro polymorphism and risk of oral cancer. DisGeNET Detail
Lack of association between MDM2 SNP309 and TP53 Arg72Pro polymorphisms with clinical outcomes in my... DisGeNET Detail
MDM2 SNP309 and TP53 R72P are significantly associated with severe neutropenia and FN, respectively,... DisGeNET Detail
This study investigated the influence of combined p53 Arg72Pro and MDM2 SNP309 on the risk of develo... DisGeNET Detail

Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs1042522 dbSNP
Genome
hg38
Position
chr17:7,676,154-7,676,154
Variant Type
snv
Reference Allele
G
Alternative Allele
C
Filtering Status (HGVD)
PASS
# of samples (HGVD)
1050
Mean of sample read depth (HGVD)
33.28
Standard deviation of sample read depth (HGVD)
19.99
Number of reference allele (HGVD)
730
Number of alternative allele (HGVD)
1369
Allele Frequency (HGVD)
0.6522153406383993
Gene Symbol (HGVD)
TP53
ToMMo VCF FILTER column value (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
PASS
Total VCF ID column value (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
rs1042522
Allele frequency, for each ALT allele (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
0.6448
Allele count in genotypes, for each ALT allele (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
10805
Total number of alleles in called genotypes (ToMMo 8.3KJPN Allele Frequency Panel(v20200831))
16758
East Asian Chromosome Counts (ExAC)
8620
East Asian Allele Counts (ExAC)
5079
East Asian Heterozygous Counts (ExAC)
2059
East Asian Homozygous Counts (ExAC)
1510
East Asian Allele Frequency (ExAC)
0.5892111368909513
Chromosome Counts in All Race (ExAC)
120924
Allele Counts in All Race (ExAC)
79805
Heterozygous Counts in All Race (ExAC)
25193
Homozygous Counts in All Race (ExAC)
27306
Allele Frequency in All Race (ExAC)
0.6599599748602428
Variant (CIViC) (CIViC Variant)
P72R
Transcript 1 (CIViC Variant)
ENST00000269305.4
Variant URL (CIViC Variant)
https://civic.genome.wustl.edu/links/variants/531
Summary (CIViC Variant)
This polymorphism is relatively widely studied across cancer types, but meta-analyses in breast, lung and cervical cancer cohorts have so far been inconclusive as to the significance of a patient's genotype at this locus as it relates to cancer susceptibility and prognosis.
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