Annotation Detail

Information
Associated Genes
TP53
Associated Variants
TP53 p.Pro72Arg (p.P72R) ( ENST00000359597.8, ENST00000413465.6, ENST00000604348.6, ENST00000269305.9, ENST00000455263.6, ENST00000420246.6, ENST00000445888.6, ENST00000576024.2, ENST00000610292.4, ENST00000610538.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 )
TP53 p.Pro72Arg (p.P72R) ( ENST00000269305.9, ENST00000359597.8, ENST00000413465.6, ENST00000420246.6, ENST00000445888.6, ENST00000455263.6, ENST00000576024.2, ENST00000604348.6, ENST00000610292.4, ENST00000610538.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 )
Associated Disease
Bone marrow failure syndrome 5 hepatocellular carcinoma bone osteosarcoma Familial cancer of breast Nasopharyngeal carcinoma Li-Fraumeni syndrome 1 Carcinoma of pancreas Glioma susceptibility 1 choroid plexus papilloma colorectal cancer Adrenocortical carcinoma, hereditary Basal cell carcinoma, susceptibility to, 7
Source Database
ClinVar
Description
NM_000546.6(TP53):c.215C>G (p.Pro72Arg) AND multiple conditions
ClinVar Allele ID
27390
ClinVar RefSeq Alternation Syntax
NM_001126118.2:c.98C>G
ClinVar RefSeq Alternation Syntax
NM_001276761.3:c.98C>G
ClinVar RefSeq Alternation Syntax
NM_001126114.3:c.215C>G
ClinVar RefSeq Alternation Syntax
NM_001126112.3:c.215C>G
ClinVar RefSeq Alternation Syntax
NM_001276696.3:c.98C>G
ClinVar RefSeq Alternation Syntax
NM_001276760.3:c.98C>G
ClinVar RefSeq Alternation Syntax
NM_001126113.3:c.215C>G
ClinVar RefSeq Alternation Syntax
NM_000546.6:c.215C>G
ClinVar RefSeq Alternation Syntax
NM_001276695.3:c.98C>G
Clinical Significance Description
Benign
Clinical Significance Last Update
2021-12-20
Clinical Significance Review Status
criteria provided, single submitter
URL
https://www.ncbi.nlm.nih.gov/clinvar/RCV002496335
ClinVar Disease
Nasopharyngeal carcinoma
ClinVar Disease
Choroid plexus papilloma
ClinVar Disease
Bone osteosarcoma
ClinVar Disease
Carcinoma of pancreas
ClinVar Disease
Bone marrow failure syndrome 5
ClinVar Disease
Adrenocortical carcinoma, hereditary
ClinVar Disease
Basal cell carcinoma, susceptibility to, 7
ClinVar Disease
Colorectal cancer
ClinVar Disease
Familial cancer of breast
ClinVar Disease
Hepatocellular carcinoma
ClinVar Disease
Glioma susceptibility 1
ClinVar Disease
Li-Fraumeni syndrome 1
Observed Origin Sample
unknown
Drugs