Vemurafenib

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Information
Drug Name
Vemurafenib
Description
Entry(CIViC)
110
CIViC
Disease Mutation EL ET ED CS VO TR Pubmed Links
melanoma BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
B Predictive Supports Sensitivity/Response Somatic 5 24508103 Detail
melanoma BRAF p.Val640Lys (p.V640K)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Lys (p.V640K)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
B Predictive Supports Sensitivity/Response Somatic 4 24508103 Detail
melanoma NRAS Q61 NRAS Q61 B Predictive Supports Resistance Somatic 4 23569304 Detail
melanoma BRAF p.Val640Lys (p.V640K)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Lys (p.V640K)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
C Predictive Supports Sensitivity/Response Somatic 3 26989536 Detail
colorectal cancer BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
B Predictive Does Not Support Sensitivity/Response Somatic 4 26460303 Detail
colorectal cancer BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
D Predictive Supports Sensitivity/Response Somatic 3 22281684 Detail
skin melanoma BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
A Predictive Supports Sensitivity/Response Somatic 5 21639808 Detail
skin melanoma BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
B Predictive Supports Sensitivity/Response Somatic 3 22356324 Detail
colorectal cancer BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
B Predictive Does Not Support Sensitivity/Response Somatic 3 25589621 Detail
thyroid gland papillary carcinoma BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
C Predictive Supports Sensitivity/Response Somatic 4 24987354 Detail
skin melanoma BRAF TRIM24-BRAF D Predictive Supports Resistance N/A 3 24345920 Detail
melanoma BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
B Predictive Supports Sensitivity/Response Somatic 4 25265494 Detail
melanoma BRAF V600 BRAF V600 B Predictive Supports Sensitivity/Response Somatic 4 25265494 Detail
gastrointestinal neuroendocrine tumor BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
C Predictive Supports Sensitivity/Response Somatic 3 27048246 Detail
skin melanoma BRAF p.Leu637Arg (p.L637R)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Leu637Arg (p.L637R)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
D Predictive Supports Sensitivity/Response Somatic 2 22798288 Detail
skin melanoma BRAF p.Leu637Ser (p.L637S)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Leu637Ser (p.L637S)
( ENST00000646891.2, ENST00000644969.2, ENST00000288602.11, ENST00000496384.7 )
D Predictive Supports Sensitivity/Response Somatic 2 22798288 Detail
skin melanoma BRAF p.Leu637Gln (p.L637Q)
( ENST00000496384.7, ENST00000288602.11, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Leu637Gln (p.L637Q)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
D Predictive Supports Sensitivity/Response Somatic 2 22798288 Detail
skin melanoma BRAF p.Lys641Glu (p.K641E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Lys641Glu (p.K641E)
( ENST00000496384.7, ENST00000288602.11, ENST00000644969.2, ENST00000646891.2 )
D Predictive Supports Sensitivity/Response Somatic 3 22798288 Detail
skin melanoma NF1 MUTATION NF1 MUTATION D Predictive Supports Resistance Somatic 2 23171796 Detail
skin melanoma NF1 MUTATION NF1 MUTATION C Predictive Supports Resistance Somatic 4 23288408 Detail
skin melanoma NRAS p.Gln61Lys (p.Q61K)
( ENST00000369535.5 ) NRAS p.Gln61Lys (p.Q61K)
( ENST00000369535.5 )
D Predictive Supports Resistance Somatic 2 22194965 Detail
skin melanoma GNAQ p.Gln209Pro (p.Q209P)
( ENST00000286548.9 ) GNAQ p.Gln209Pro (p.Q209P)
( ENST00000286548.9 )
C Predictive Supports Resistance Somatic 2 24504448 Detail
lung non-small cell carcinoma BRAF V600 BRAF V600 B Predictive Supports Sensitivity/Response Somatic 3 26287849 Detail
Langerhans-cell histiocytosis BRAF V600 BRAF V600 B Predictive Supports Sensitivity/Response Somatic 3 26287849 Detail
colorectal cancer BRAF V600 BRAF V600 B Predictive Supports Resistance Somatic 3 26287849 Detail
hairy cell leukemia BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
B Predictive Supports Sensitivity/Response Somatic 2 26352686 Detail
hairy cell leukemia KRAS p.Gly12Asp (p.G12D)
( ENST00000256078.10, ENST00000311936.8, ENST00000556131.2, ENST00000557334.6, ENST00000685328.1, ENST00000686969.1, ENST00000688940.1, ENST00000692768.1, ENST00000693229.1 ) KRAS p.Gly12Asp (p.G12D)
( ENST00000692768.1, ENST00000256078.10, ENST00000311936.8, ENST00000556131.2, ENST00000557334.6, ENST00000685328.1, ENST00000686969.1, ENST00000688940.1, ENST00000693229.1 )
C Predictive Supports Resistance Somatic 2 26352686 Detail
skin melanoma MET OVEREXPRESSION
( ENST00000318493.11 ) MET OVEREXPRESSION
( ENST00000318493.11 )
B Predictive Supports Resistance N/A 4 26359985 Detail
skin melanoma MET OVEREXPRESSION
( ENST00000318493.11 ) MET OVEREXPRESSION
( ENST00000318493.11 )
B Predictive Does Not Support Resistance N/A 3 23802768 Detail
colorectal cancer MET AMPLIFICATION
( ENST00000318493.11 ) MET AMPLIFICATION
( ENST00000318493.11 )
C Predictive Supports Sensitivity/Response N/A 4 27325282 Detail
colorectal cancer BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
C Predictive Supports Sensitivity/Response Somatic 2 27325282 Detail
thyroid gland papillary carcinoma BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
B Predictive Supports Sensitivity/Response Somatic 3 27460442 Detail
colorectal cancer BRAF V600 BRAF V600 B Predictive Does Not Support Sensitivity/Response Somatic 2 26287849 Detail
melanoma MAP2K1 p.Cys121Ser (p.C121S)
( ENST00000307102.10, ENST00000685172.1, ENST00000685763.1, ENST00000686347.1, ENST00000689951.1, ENST00000691576.1, ENST00000691937.1, ENST00000692683.1, ENST00000693150.1 ) MAP2K1 p.Cys121Ser (p.C121S)
( ENST00000307102.10, ENST00000689951.1, ENST00000691937.1, ENST00000691576.1, ENST00000685172.1, ENST00000685763.1, ENST00000693150.1, ENST00000686347.1, ENST00000692683.1 )
C Predictive Supports Resistance Somatic 4 21383288 Detail
melanoma STAG2 UNDEREXPRESSION
( ENST00000371157.7 ) STAG2 UNDEREXPRESSION
( ENST00000371157.7 )
D Predictive Supports Resistance N/A 4 27500726 Detail
melanoma STAG3 UNDEREXPRESSION
( ENST00000426455.5 ) STAG3 UNDEREXPRESSION
( ENST00000426455.5 )
D Predictive Supports Resistance N/A 4 27500726 Detail
melanoma BRAF p.Leu545His (p.L545H)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Leu545His (p.L545H)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
D Predictive Supports Resistance Somatic 4 24112705 Detail
melanoma BRAF p.Leu545His (p.L545H)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Leu545His (p.L545H)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
B Predictive Supports Resistance Somatic 3 25515853 Detail
multiple myeloma BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
C Predictive Supports Sensitivity/Response Somatic 3 24997557 Detail
multiple myeloma BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
C Predictive Supports Sensitivity/Response Somatic 2 24997557 Detail
melanoma SOX10 LOSS
( ENST00000396884.8 ) SOX10 LOSS
( ENST00000396884.8 )
D Predictive Supports Resistance N/A 4 24670642 Detail
melanoma BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
B Predictive Supports Sensitivity/Response Somatic 4 20818844 Detail
colorectal cancer BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
B Predictive Supports Sensitivity/Response Somatic 4 27729313 Detail
colorectal cancer ARAF p.Ser490Thr (p.S490T)
( ENST00000377045.9 ) ARAF p.Ser490Thr (p.S490T)
( ENST00000377045.9 )
C Predictive Supports Resistance Somatic 1 27729313 Detail
colorectal cancer GNAS p.Arg844Cys (p.R844C)
( ENST00000371095.7, ENST00000265620.11, ENST00000306090.12, ENST00000313949.11, ENST00000349036.9, ENST00000354359.12, ENST00000371075.7, ENST00000371085.8, ENST00000480232.6, ENST00000371100.9, ENST00000371102.8, ENST00000419558.7, ENST00000453292.7, ENST00000462499.6, ENST00000464788.6, ENST00000467227.6, ENST00000467321.6, ENST00000468895.6, ENST00000469431.6, ENST00000470512.6, ENST00000472183.6, ENST00000476935.6, ENST00000477931.5, ENST00000683015.1, ENST00000682803.1, ENST00000676826.2, ENST00000667293.2, ENST00000663479.2, ENST00000657090.1, ENST00000656419.1, ENST00000604005.6, ENST00000603546.2, ENST00000492907.6, ENST00000488652.6, ENST00000488546.6, ENST00000485673.6, ENST00000482112.6, ENST00000481039.6, ENST00000480975.5, ENST00000478585.6 ) GNAS p.Arg844Cys (p.R844C)
( ENST00000470512.6, ENST00000467227.6, ENST00000476935.6, ENST00000485673.6, ENST00000488546.6, ENST00000492907.6, ENST00000371075.7, ENST00000371095.7, ENST00000603546.2, ENST00000481039.6, ENST00000469431.6, ENST00000482112.6, ENST00000371102.8, ENST00000488652.6, ENST00000371100.9, ENST00000480232.6, ENST00000354359.12, ENST00000371085.8, ENST00000480975.5, ENST00000464788.6, ENST00000477931.5, ENST00000604005.6, ENST00000472183.6, ENST00000478585.6, ENST00000419558.7, ENST00000683015.1, ENST00000265620.11, ENST00000306090.12, ENST00000313949.11, ENST00000349036.9, ENST00000453292.7, ENST00000682803.1, ENST00000676826.2, ENST00000462499.6, ENST00000667293.2, ENST00000663479.2, ENST00000657090.1, ENST00000656419.1, ENST00000467321.6, ENST00000468895.6 )
C Predictive Supports Resistance Somatic 2 27729313 Detail
melanoma PIK3CA p.Glu545Lys (p.E545K)
( ENST00000263967.4, ENST00000643187.1 ) PIK3CA p.Glu545Lys (p.E545K)
( ENST00000263967.4, ENST00000643187.1 )
D Predictive Supports Resistance Somatic 2 24265155 Detail
melanoma PIK3CA p.Glu545Gly (p.E545G)
( ENST00000263967.4, ENST00000643187.1 ) PIK3CA p.Glu545Gly (p.E545G)
( ENST00000263967.4, ENST00000643187.1 )
D Predictive Supports Resistance Somatic 2 24265155 Detail
melanoma BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
B Predictive Supports Sensitivity/Response Somatic 23569304 Detail
melanoma BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
B Predictive Supports Sensitivity/Response Somatic 26557775 Detail
melanoma BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
B Predictive Supports Sensitivity/Response Somatic 25524477 Detail
ganglioglioma BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
C Predictive Supports Sensitivity/Response Somatic 25524464 Detail
ovarian cystadenocarcinoma BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
C Predictive Supports Sensitivity/Response Somatic 26490654 Detail
skin squamous cell carcinoma HRAS p.Gly13Asp (p.G13D)
( ENST00000311189.8, ENST00000397594.7, ENST00000397596.6, ENST00000417302.7, ENST00000451590.5 ) HRAS p.Gly13Asp (p.G13D)
( ENST00000311189.8, ENST00000397594.7, ENST00000397596.6, ENST00000417302.7, ENST00000451590.5 )
C Predictive Supports Resistance Somatic 22256804 Detail
melanoma KRAS p.Gly12Asp (p.G12D)
( ENST00000256078.10, ENST00000311936.8, ENST00000556131.2, ENST00000557334.6, ENST00000685328.1, ENST00000686969.1, ENST00000688940.1, ENST00000692768.1, ENST00000693229.1 ) KRAS p.Gly12Asp (p.G12D)
( ENST00000692768.1, ENST00000256078.10, ENST00000311936.8, ENST00000556131.2, ENST00000557334.6, ENST00000685328.1, ENST00000686969.1, ENST00000688940.1, ENST00000693229.1 )
D Predictive Supports Resistance Somatic 2 24265155 Detail
melanoma AKT1 p.Glu17Lys (p.E17K)
( ENST00000402615.6, ENST00000349310.7, ENST00000554848.5, ENST00000555528.5, ENST00000407796.7, ENST00000553797.2, ENST00000554192.6, ENST00000554581.5, ENST00000555458.6, ENST00000649815.2, ENST00000683722.1, ENST00000714123.1, ENST00000714130.1 ) AKT1 p.Glu17Lys (p.E17K)
( ENST00000349310.7, ENST00000402615.6, ENST00000407796.7, ENST00000553797.2, ENST00000554192.6, ENST00000554581.5, ENST00000554848.5, ENST00000555458.6, ENST00000555528.5, ENST00000649815.2, ENST00000683722.1, ENST00000714123.1, ENST00000714130.1 )
D Predictive Supports Resistance Somatic 24265155 Detail
melanoma BRAF p.Val640Lys (p.V640K)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Lys (p.V640K)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
B Predictive Supports Sensitivity/Response Somatic 25524477 Detail
melanoma AKT1 p.Gln79Lys (p.Q79K)
( ENST00000554192.6, ENST00000554581.5, ENST00000402615.6, ENST00000554848.5, ENST00000555458.6, ENST00000407796.7, ENST00000349310.7, ENST00000553797.2, ENST00000555528.5, ENST00000649815.2, ENST00000683722.1, ENST00000714123.1, ENST00000714130.1 ) AKT1 p.Gln79Lys (p.Q79K)
( ENST00000349310.7, ENST00000402615.6, ENST00000407796.7, ENST00000553797.2, ENST00000554192.6, ENST00000554581.5, ENST00000554848.5, ENST00000555458.6, ENST00000555528.5, ENST00000649815.2, ENST00000683722.1, ENST00000714123.1, ENST00000714130.1 )
D Predictive Supports Resistance Somatic 4 24265152 Detail
melanoma BRAF p.Val640Asp (p.V640D)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Asp (p.V640D)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
D Predictive Supports Sensitivity/Response Somatic 18287029 Detail
melanoma BRAF p.Val640Asp (p.V640D)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Asp (p.V640D)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
D Predictive Supports Sensitivity/Response Somatic 20551065 Detail
melanoma AKT1 p.Gln79Lys (p.Q79K)
( ENST00000554192.6, ENST00000554581.5, ENST00000402615.6, ENST00000554848.5, ENST00000555458.6, ENST00000407796.7, ENST00000349310.7, ENST00000553797.2, ENST00000555528.5, ENST00000649815.2, ENST00000683722.1, ENST00000714123.1, ENST00000714130.1 ) AKT1 p.Gln79Lys (p.Q79K)
( ENST00000349310.7, ENST00000402615.6, ENST00000407796.7, ENST00000553797.2, ENST00000554192.6, ENST00000554581.5, ENST00000554848.5, ENST00000555458.6, ENST00000555528.5, ENST00000649815.2, ENST00000683722.1, ENST00000714123.1, ENST00000714130.1 )
D Predictive Supports Resistance Somatic 24265155 Detail
melanoma AKT3 p.Glu17Lys (p.E17K)
( ENST00000492957.2, ENST00000263826.12, ENST00000336199.9, ENST00000366539.6, ENST00000366540.5, ENST00000672238.1, ENST00000672578.1, ENST00000673400.1, ENST00000673466.1, ENST00000680056.1 ) AKT3 p.Glu17Lys (p.E17K)
( ENST00000263826.12, ENST00000336199.9, ENST00000366539.6, ENST00000366540.5, ENST00000492957.2, ENST00000672238.1, ENST00000672578.1, ENST00000673400.1, ENST00000673466.1, ENST00000680056.1 )
D Predictive Supports Resistance Somatic 3 24265155 Detail
melanoma PIK3R2 N561D PIK3R2 N561D D Predictive Supports Resistance Somatic 3 24265155 Detail
melanoma PIK3CA p.Asp350Gly (p.D350G)
( ENST00000263967.4, ENST00000643187.1 ) PIK3CA p.Asp350Gly (p.D350G)
( ENST00000263967.4, ENST00000643187.1 )
D Predictive Supports Resistance Somatic 2 24265155 Detail
cholangiocarcinoma BRAF V600 BRAF V600 B Predictive Supports Sensitivity/Response Somatic 4 26287849 Detail
cholangiocarcinoma BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
C Predictive Supports Sensitivity/Response Somatic 3 26687137 Detail
lung non-small cell carcinoma BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
B Predictive Supports Sensitivity/Response Somatic 4 29320312 Detail
ovarian cancer BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
B Predictive Supports Sensitivity/Response Somatic 3 29320312 Detail
colorectal cancer BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
C Predictive Supports Sensitivity/Response Somatic 2 29320312 Detail
Anaplastic thyroid carcinoma BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
C Predictive Supports Sensitivity/Response Somatic 3 29320312 Detail
laryngeal squamous cell carcinoma BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
C Predictive Supports Sensitivity/Response Somatic 3 29320312 Detail
cancer BRAF p.Gly504Val (p.G504V)
( ENST00000644969.2, ENST00000288602.11, ENST00000496384.7, ENST00000646891.2 ) BRAF p.Gly504Val (p.G504V)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
C Predictive Does Not Support Sensitivity/Response Somatic 2 29320312 Detail
cancer BRAF p.Gly509Ala (p.G509A)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Gly509Ala (p.G509A)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
C Predictive Does Not Support Sensitivity/Response Somatic 2 29320312 Detail
cancer BRAF APC BRAF APC C Predictive Does Not Support Sensitivity/Response Somatic 2 29320312 Detail
cancer BRAF p.Asn621Ser (p.N621S)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Asn621Ser (p.N621S)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
C Predictive Does Not Support Sensitivity/Response Somatic 2 29320312 Detail
cancer BRAF p.Gly506Val (p.G506V)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Gly506Val (p.G506V)
( ENST00000288602.11, ENST00000646891.2, ENST00000496384.7, ENST00000644969.2 )
C Predictive Does Not Support Sensitivity/Response Somatic 2 29320312 Detail
cancer BRAF p.Gly636Arg (p.G636R)
( ENST00000496384.7, ENST00000288602.11, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Gly636Arg (p.G636R)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
C Predictive Does Not Support Sensitivity/Response Somatic 2 29320312 Detail
cancer BRAF p.Gly646Glu (p.G646E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Gly646Glu (p.G646E)
( ENST00000644969.2, ENST00000646891.2, ENST00000288602.11, ENST00000496384.7 )
C Predictive Does Not Support Sensitivity/Response Somatic 2 29320312 Detail
cancer BRAF p.Leu637Gln (p.L637Q)
( ENST00000496384.7, ENST00000288602.11, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Leu637Gln (p.L637Q)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
C Predictive Does Not Support Sensitivity/Response Somatic 2 29320312 Detail
cancer BRAF p.Pro771Thr (p.P771T)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Pro771Thr (p.P771T)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
C Predictive Does Not Support Sensitivity/Response Somatic 2 29320312 Detail
cancer BRAF APC BRAF APC C Predictive Does Not Support Sensitivity/Response Somatic 2 29320312 Detail
cancer BRAF APC BRAF APC C Predictive Does Not Support Sensitivity/Response Somatic 2 29320312 Detail
cancer BRAF MACF1-BRAF Fusion C Predictive Does Not Support Sensitivity/Response Somatic 2 29320312 Detail
cancer BRAF WASFL-BRAF Fusion BRAF WASFL-BRAF Fusion C Predictive Does Not Support Sensitivity/Response Somatic 2 29320312 Detail
pancreatic cancer BRAF CUX1-BRAF C Predictive Supports Sensitivity/Response Somatic 2 29320312 Detail
melanoma BRAF V600 BRAF V600 A Predictive Supports Sensitivity/Response Somatic 5 27480103 Detail
Anaplastic thyroid carcinoma BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
B Predictive Supports Sensitivity/Response Somatic 3 26287849 Detail
melanoma AKT1 OVEREXPRESSION AKT1 OVEREXPRESSION D Predictive Does Not Support Resistance Somatic 3 24265155 Detail
melanoma AKT3 OVEREXPRESSION AKT3 OVEREXPRESSION D Predictive Supports Resistance Somatic 2 24265155 Detail
melanoma BRAF V600E/K AMPLIFICATION BRAF V600E/K AMPLIFICATION B Predictive Supports Resistance Somatic 2 24265155 Detail
melanoma NRAS MUTATION NRAS MUTATION B Predictive Supports Resistance Somatic 2 24265155 Detail
melanoma KRAS MUTATION KRAS MUTATION B Predictive Supports Resistance Somatic 2 24265155 Detail
melanoma PIK3R2 OVEREXPRESSION PIK3R2 OVEREXPRESSION D Predictive Does Not Support Resistance Somatic 2 24265155 Detail
melanoma PREX2 R172I PREX2 R172I C Predictive Supports Resistance Somatic 4 24265155 Detail
melanoma PTEN DELETION
( ENST00000371953.8 ) PTEN DELETION
( ENST00000371953.8 )
D Predictive Supports Resistance Somatic 4 24265155 Detail
melanoma PIK3CA AMPLIFICATION
( ENST00000263967.4, ENST00000497599.5 ) PIK3CA AMPLIFICATION
( ENST00000263967.4 )
D Predictive Supports Resistance Somatic 2 24265155 Detail
melanoma KRAS AMPLIFICATION
( ENST00000256078.10 ) KRAS AMPLIFICATION
( ENST00000256078.10 )
D Predictive Supports Resistance Somatic 2 24265155 Detail
melanoma BRAF APC BRAF APC B Predictive Supports Resistance Somatic 3 24265155 Detail
melanoma BRAF APC BRAF APC B Predictive Supports Resistance Somatic 3 24265155 Detail
melanoma BRAF V600 BRAF V600 B Predictive Supports Sensitivity/Response Somatic 3 25037139 Detail
melanoma BRAF AGK-BRAF D Predictive Supports Resistance Somatic 2 23890088 Detail
melanoma BRAF PAPSS1-BRAF D Predictive Supports Resistance Somatic 3 24345920 Detail
melanoma BRAF p.Leu637Arg (p.L637R)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Leu637Arg (p.L637R)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
C Predictive Supports Sensitivity/Response Somatic 4 23715574 Detail
colorectal cancer BRAF V600 BRAF V600 B Predictive Supports Sensitivity/Response Somatic 3 Detail
colorectal cancer BRAF p.Gly506Val (p.G506V)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Gly506Val (p.G506V)
( ENST00000288602.11, ENST00000646891.2, ENST00000496384.7, ENST00000644969.2 )
D Predictive Does Not Support Sensitivity/Response Somatic 3 28783719 Detail
Solid Tumor BRAF p.Gly506Val (p.G506V)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Gly506Val (p.G506V)
( ENST00000288602.11, ENST00000646891.2, ENST00000496384.7, ENST00000644969.2 )
D Predictive Does Not Support Sensitivity/Response Somatic 3 28783719 Detail
Solid Tumor BRAF p.Asp634Gly (p.D634G)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Asp634Gly (p.D634G)
( ENST00000646891.2, ENST00000496384.7, ENST00000644969.2, ENST00000288602.11 )
D Predictive Does Not Support Sensitivity/Response Somatic 3 28783719 Detail
melanoma RAC1 p.Pro29Ser (p.P29S)
( ENST00000348035.9, ENST00000356142.4, ENST00000704002.1 ) RAC1 p.Pro29Ser (p.P29S)
( ENST00000348035.9, ENST00000356142.4, ENST00000704002.1 )
D Predictive Supports Resistance Somatic 4 25056119 Detail
melanoma BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
D Predictive Supports Resistance Somatic 3 24576830 Detail
colorectal cancer BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
D Predictive Supports Sensitivity/Response Somatic 2 22180495 Detail
colorectal cancer BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
D Predictive Supports Sensitivity/Response Somatic 2 22180495 Detail
Annotation
Description Associated Genes Associated Variants Sensitivity Supported Source Links
The BRIM-3 Phase III trial NCT01006980 assessed BR... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
In the Phase III study of vemurafenib versus dacar... BRAF BRAF p.Val640Lys (p.V640K)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Lys (p.V640K)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
Vemurafenib resistance is associated with gain of ... NRAS NRAS Q61 NRAS Q61 Resitance or Non-Reponse true CIViC Evidence detail
A 53 year old male presented with a scalp lesion w... BRAF BRAF p.Val640Lys (p.V640K)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Lys (p.V640K)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
In this Phase II pilot study (NCT00405587) of BRAF... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity false CIViC Evidence detail
5 of 7 colorectal cancer (CRC) cell lines with BRA... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
Phase 3 randomized clinical trial comparing vemura... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
Phase 2 trial in 132 patients with previously trea... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
Treatment response to mutant BRAF inhibitor vemura... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity false CIViC Evidence detail
A 73 year old patient with prior history of breast... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
Foundation One NGS assay and targeted RNAseq ident... BRAF BRAF TRIM24-BRAF Resitance or Non-Reponse true CIViC Evidence detail
In this Phase III trial (coBRIM, NCT01689519) of 4... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
In a randomized phase 3 study, previously untreate... BRAF BRAF V600 BRAF V600 Sensitivity true CIViC Evidence detail
BRAF mutations were identified in 9% of 108 cases ... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
Preclinical study in 293H cell line. Ectopic expre... BRAF BRAF p.Leu637Arg (p.L637R)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Leu637Arg (p.L637R)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
Preclinical study in 293H cell line. Ectopic expre... BRAF BRAF p.Leu637Ser (p.L637S)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Leu637Ser (p.L637S)
( ENST00000646891.2, ENST00000644969.2, ENST00000288602.11, ENST00000496384.7 )
Sensitivity true CIViC Evidence detail
Preclinical study in 293H cell line. Ectopic expre... BRAF BRAF p.Leu637Gln (p.L637Q)
( ENST00000496384.7, ENST00000288602.11, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Leu637Gln (p.L637Q)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
Preclinical study in 293H cell line. Ectopic expre... BRAF BRAF p.Lys641Glu (p.K641E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Lys641Glu (p.K641E)
( ENST00000496384.7, ENST00000288602.11, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
Preclinical study of mouse melanoma in-vitro and i... NF1 NF1 MUTATION NF1 MUTATION Resitance or Non-Reponse true CIViC Evidence detail
NF1 was identified in an unbiased RNAi screen as m... NF1 NF1 MUTATION NF1 MUTATION Resitance or Non-Reponse true CIViC Evidence detail
Preclinical study in melanoma cell lines. NRAS Q61... NRAS NRAS p.Gln61Lys (p.Q61K)
( ENST00000369535.5 ) NRAS p.Gln61Lys (p.Q61K)
( ENST00000369535.5 )
Resitance or Non-Reponse true CIViC Evidence detail
A 26-year old patient presented with vemurafenib r... GNAQ GNAQ p.Gln209Pro (p.Q209P)
( ENST00000286548.9 ) GNAQ p.Gln209Pro (p.Q209P)
( ENST00000286548.9 )
Resitance or Non-Reponse true CIViC Evidence detail
Patients with BRAF-V600 mutated cancers were ident... BRAF BRAF V600 BRAF V600 Sensitivity true CIViC Evidence detail
Patients with BRAF-V600 mutated cancers were ident... BRAF BRAF V600 BRAF V600 Sensitivity true CIViC Evidence detail
Patients with BRAF-V600 mutated cancers were ident... BRAF BRAF V600 BRAF V600 Resitance or Non-Reponse true CIViC Evidence detail
Two clinical trials evaluated the effects of vemur... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
One patient enrolled in a clinical study to evalua... KRAS KRAS p.Gly12Asp (p.G12D)
( ENST00000256078.10, ENST00000311936.8, ENST00000556131.2, ENST00000557334.6, ENST00000685328.1, ENST00000686969.1, ENST00000688940.1, ENST00000692768.1, ENST00000693229.1 ) KRAS p.Gly12Asp (p.G12D)
( ENST00000692768.1, ENST00000256078.10, ENST00000311936.8, ENST00000556131.2, ENST00000557334.6, ENST00000685328.1, ENST00000686969.1, ENST00000688940.1, ENST00000693229.1 )
Resitance or Non-Reponse true CIViC Evidence detail
Whole exome sequencing, transcriptome and methylom... MET MET OVEREXPRESSION
( ENST00000318493.11 ) MET OVEREXPRESSION
( ENST00000318493.11 )
Resitance or Non-Reponse true CIViC Evidence detail
FFPE tumours from patients enrolled in the BRIM2 (... MET MET OVEREXPRESSION
( ENST00000318493.11 ) MET OVEREXPRESSION
( ENST00000318493.11 )
Resitance or Non-Reponse false CIViC Evidence detail
Case report of a patient with BRAF V600E mutant me... MET MET AMPLIFICATION
( ENST00000318493.11 ) MET AMPLIFICATION
( ENST00000318493.11 )
Sensitivity true CIViC Evidence detail
Case report of a patient with BRAF V600E mutant me... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
Open-label non-randomised phase 2 trial in patient... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
Patients with BRAF-V600 mutated cancers were ident... BRAF BRAF V600 BRAF V600 Sensitivity false CIViC Evidence detail
A patient with BRAF-mutant melanoma relapsed after... MAP2K1 MAP2K1 p.Cys121Ser (p.C121S)
( ENST00000307102.10, ENST00000685172.1, ENST00000685763.1, ENST00000686347.1, ENST00000689951.1, ENST00000691576.1, ENST00000691937.1, ENST00000692683.1, ENST00000693150.1 ) MAP2K1 p.Cys121Ser (p.C121S)
( ENST00000307102.10, ENST00000689951.1, ENST00000691937.1, ENST00000691576.1, ENST00000685172.1, ENST00000685763.1, ENST00000693150.1, ENST00000686347.1, ENST00000692683.1 )
Resitance or Non-Reponse true CIViC Evidence detail
A375 melanoma cells containing an inducible shRNA ... STAG2 STAG2 UNDEREXPRESSION
( ENST00000371157.7 ) STAG2 UNDEREXPRESSION
( ENST00000371157.7 )
Resitance or Non-Reponse true CIViC Evidence detail
A375 melanoma cells containing an inducible shRNA ... STAG3 STAG3 UNDEREXPRESSION
( ENST00000426455.5 ) STAG3 UNDEREXPRESSION
( ENST00000426455.5 )
Resitance or Non-Reponse true CIViC Evidence detail
Using a mutation screen in the BRAFV600E melanoma ... BRAF BRAF p.Leu545His (p.L545H)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Leu545His (p.L545H)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Resitance or Non-Reponse true CIViC Evidence detail
In this study, the investigators followed 10 patie... BRAF BRAF p.Leu545His (p.L545H)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Leu545His (p.L545H)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Resitance or Non-Reponse true CIViC Evidence detail
A 65-year-old man presented with stage II myeloma.... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
A 54-year-old man presented with stage II myeloma.... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
FACS-assisted shRNA genetic screen identified SOX1... SOX10 SOX10 LOSS
( ENST00000396884.8 ) SOX10 LOSS
( ENST00000396884.8 )
Resitance or Non-Reponse true CIViC Evidence detail
Multicenter, phase 1, dose-escalation trial of PLX... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
Phase 1b study of vemurafenib, cetuximab and irino... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
Phase 1b study of vemurafenib, cetuximab and irino... ARAF ARAF p.Ser490Thr (p.S490T)
( ENST00000377045.9 ) ARAF p.Ser490Thr (p.S490T)
( ENST00000377045.9 )
Resitance or Non-Reponse true CIViC Evidence detail
Phase 1b study of vemurafenib, cetuximab and irino... GNAS GNAS p.Arg844Cys (p.R844C)
( ENST00000371095.7, ENST00000265620.11, ENST00000306090.12, ENST00000313949.11, ENST00000349036.9, ENST00000354359.12, ENST00000371075.7, ENST00000371085.8, ENST00000480232.6, ENST00000371100.9, ENST00000371102.8, ENST00000419558.7, ENST00000453292.7, ENST00000462499.6, ENST00000464788.6, ENST00000467227.6, ENST00000467321.6, ENST00000468895.6, ENST00000469431.6, ENST00000470512.6, ENST00000472183.6, ENST00000476935.6, ENST00000477931.5, ENST00000683015.1, ENST00000682803.1, ENST00000676826.2, ENST00000667293.2, ENST00000663479.2, ENST00000657090.1, ENST00000656419.1, ENST00000604005.6, ENST00000603546.2, ENST00000492907.6, ENST00000488652.6, ENST00000488546.6, ENST00000485673.6, ENST00000482112.6, ENST00000481039.6, ENST00000480975.5, ENST00000478585.6 ) GNAS p.Arg844Cys (p.R844C)
( ENST00000470512.6, ENST00000467227.6, ENST00000476935.6, ENST00000485673.6, ENST00000488546.6, ENST00000492907.6, ENST00000371075.7, ENST00000371095.7, ENST00000603546.2, ENST00000481039.6, ENST00000469431.6, ENST00000482112.6, ENST00000371102.8, ENST00000488652.6, ENST00000371100.9, ENST00000480232.6, ENST00000354359.12, ENST00000371085.8, ENST00000480975.5, ENST00000464788.6, ENST00000477931.5, ENST00000604005.6, ENST00000472183.6, ENST00000478585.6, ENST00000419558.7, ENST00000683015.1, ENST00000265620.11, ENST00000306090.12, ENST00000313949.11, ENST00000349036.9, ENST00000453292.7, ENST00000682803.1, ENST00000676826.2, ENST00000462499.6, ENST00000667293.2, ENST00000663479.2, ENST00000657090.1, ENST00000656419.1, ENST00000467321.6, ENST00000468895.6 )
Resitance or Non-Reponse true CIViC Evidence detail
An in vitro study of M229 (a human melanoma cell l... PIK3CA PIK3CA p.Glu545Lys (p.E545K)
( ENST00000263967.4, ENST00000643187.1 ) PIK3CA p.Glu545Lys (p.E545K)
( ENST00000263967.4, ENST00000643187.1 )
Resitance or Non-Reponse true CIViC Evidence detail
An in vitro study of M229 (a human melanoma cell l... PIK3CA PIK3CA p.Glu545Gly (p.E545G)
( ENST00000263967.4, ENST00000643187.1 ) PIK3CA p.Glu545Gly (p.E545G)
( ENST00000263967.4, ENST00000643187.1 )
Resitance or Non-Reponse true CIViC Evidence detail
In a phase 2 clinical trial (NCT00949702) of 132 B... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
In a clinical study of Polish, stage IIIC/IV, mel... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
In a retrospective study of 300 stage IV melanoma ... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
In a case report, a cervicomedullary ganglioglioma... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
A stage 4B, low-grade papillary serous ovarian ade... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
In a retrospective study of 23 patients with BRAF ... HRAS HRAS p.Gly13Asp (p.G13D)
( ENST00000311189.8, ENST00000397594.7, ENST00000397596.6, ENST00000417302.7, ENST00000451590.5 ) HRAS p.Gly13Asp (p.G13D)
( ENST00000311189.8, ENST00000397594.7, ENST00000397596.6, ENST00000417302.7, ENST00000451590.5 )
Resitance or Non-Reponse true CIViC Evidence detail
In vitro studies of M229 (a human melanoma cell li... KRAS KRAS p.Gly12Asp (p.G12D)
( ENST00000256078.10, ENST00000311936.8, ENST00000556131.2, ENST00000557334.6, ENST00000685328.1, ENST00000686969.1, ENST00000688940.1, ENST00000692768.1, ENST00000693229.1 ) KRAS p.Gly12Asp (p.G12D)
( ENST00000692768.1, ENST00000256078.10, ENST00000311936.8, ENST00000556131.2, ENST00000557334.6, ENST00000685328.1, ENST00000686969.1, ENST00000688940.1, ENST00000693229.1 )
Resitance or Non-Reponse true CIViC Evidence detail
In an in vitro study, a M229 cell line endogenousl... AKT1 AKT1 p.Glu17Lys (p.E17K)
( ENST00000402615.6, ENST00000349310.7, ENST00000554848.5, ENST00000555528.5, ENST00000407796.7, ENST00000553797.2, ENST00000554192.6, ENST00000554581.5, ENST00000555458.6, ENST00000649815.2, ENST00000683722.1, ENST00000714123.1, ENST00000714130.1 ) AKT1 p.Glu17Lys (p.E17K)
( ENST00000349310.7, ENST00000402615.6, ENST00000407796.7, ENST00000553797.2, ENST00000554192.6, ENST00000554581.5, ENST00000554848.5, ENST00000555458.6, ENST00000555528.5, ENST00000649815.2, ENST00000683722.1, ENST00000714123.1, ENST00000714130.1 )
Resitance or Non-Reponse true CIViC Evidence detail
In a retrospective study of 300 stage IV melanoma ... BRAF BRAF p.Val640Lys (p.V640K)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Lys (p.V640K)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
The AKT1 Q79K mutation has been shown to confer re... AKT1 AKT1 p.Gln79Lys (p.Q79K)
( ENST00000554192.6, ENST00000554581.5, ENST00000402615.6, ENST00000554848.5, ENST00000555458.6, ENST00000407796.7, ENST00000349310.7, ENST00000553797.2, ENST00000555528.5, ENST00000649815.2, ENST00000683722.1, ENST00000714123.1, ENST00000714130.1 ) AKT1 p.Gln79Lys (p.Q79K)
( ENST00000349310.7, ENST00000402615.6, ENST00000407796.7, ENST00000553797.2, ENST00000554192.6, ENST00000554581.5, ENST00000554848.5, ENST00000555458.6, ENST00000555528.5, ENST00000649815.2, ENST00000683722.1, ENST00000714123.1, ENST00000714130.1 )
Resitance or Non-Reponse true CIViC Evidence detail
In an in vitro study, WM2664, a BRAF V600D express... BRAF BRAF p.Val640Asp (p.V640D)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Asp (p.V640D)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
In an in vitro study, the WM2664 and WM239A cell l... BRAF BRAF p.Val640Asp (p.V640D)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Asp (p.V640D)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
In an in vitro study, a M229 cell line endogenousl... AKT1 AKT1 p.Gln79Lys (p.Q79K)
( ENST00000554192.6, ENST00000554581.5, ENST00000402615.6, ENST00000554848.5, ENST00000555458.6, ENST00000407796.7, ENST00000349310.7, ENST00000553797.2, ENST00000555528.5, ENST00000649815.2, ENST00000683722.1, ENST00000714123.1, ENST00000714130.1 ) AKT1 p.Gln79Lys (p.Q79K)
( ENST00000349310.7, ENST00000402615.6, ENST00000407796.7, ENST00000553797.2, ENST00000554192.6, ENST00000554581.5, ENST00000554848.5, ENST00000555458.6, ENST00000555528.5, ENST00000649815.2, ENST00000683722.1, ENST00000714123.1, ENST00000714130.1 )
Resitance or Non-Reponse true CIViC Evidence detail
An in vitro study of M229 (a human melanoma cell l... AKT3 AKT3 p.Glu17Lys (p.E17K)
( ENST00000492957.2, ENST00000263826.12, ENST00000336199.9, ENST00000366539.6, ENST00000366540.5, ENST00000672238.1, ENST00000672578.1, ENST00000673400.1, ENST00000673466.1, ENST00000680056.1 ) AKT3 p.Glu17Lys (p.E17K)
( ENST00000263826.12, ENST00000336199.9, ENST00000366539.6, ENST00000366540.5, ENST00000492957.2, ENST00000672238.1, ENST00000672578.1, ENST00000673400.1, ENST00000673466.1, ENST00000680056.1 )
Resitance or Non-Reponse true CIViC Evidence detail
An in vitro study of WM2664 (a human melanoma cell... PIK3R2 PIK3R2 N561D PIK3R2 N561D Resitance or Non-Reponse true CIViC Evidence detail
An in vitro study of M229 (a human melanoma cell l... PIK3CA PIK3CA p.Asp350Gly (p.D350G)
( ENST00000263967.4, ENST00000643187.1 ) PIK3CA p.Asp350Gly (p.D350G)
( ENST00000263967.4, ENST00000643187.1 )
Resitance or Non-Reponse true CIViC Evidence detail
Eight patients with BRAF V600 (7 with V600E, 1 wit... BRAF BRAF V600 BRAF V600 Sensitivity true CIViC Evidence detail
Patients with metastatic cholangiocarcinoma havori... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
The phase 2a MyPathway study assigned patients wit... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
The phase 2a MyPathway study assigned patients wit... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
The phase 2a MyPathway study assigned patients wit... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
The phase 2a MyPathway study assigned patients wit... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
The phase 2a MyPathway study assigned patients wit... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
The phase 2a MyPathway study assigned patients wit... BRAF BRAF p.Gly504Val (p.G504V)
( ENST00000644969.2, ENST00000288602.11, ENST00000496384.7, ENST00000646891.2 ) BRAF p.Gly504Val (p.G504V)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity false CIViC Evidence detail
The phase 2a MyPathway study assigned patients wit... BRAF BRAF p.Gly509Ala (p.G509A)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Gly509Ala (p.G509A)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity false CIViC Evidence detail
The phase 2a MyPathway study assigned patients wit... BRAF BRAF APC BRAF APC Sensitivity false CIViC Evidence detail
The phase 2a MyPathway study assigned patients wit... BRAF BRAF p.Asn621Ser (p.N621S)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Asn621Ser (p.N621S)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity false CIViC Evidence detail
The phase 2a MyPathway study assigned patients wit... BRAF BRAF p.Gly506Val (p.G506V)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Gly506Val (p.G506V)
( ENST00000288602.11, ENST00000646891.2, ENST00000496384.7, ENST00000644969.2 )
Sensitivity false CIViC Evidence detail
The phase 2a MyPathway study assigned patients wit... BRAF BRAF p.Gly636Arg (p.G636R)
( ENST00000496384.7, ENST00000288602.11, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Gly636Arg (p.G636R)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity false CIViC Evidence detail
The phase 2a MyPathway study assigned patients wit... BRAF BRAF p.Gly646Glu (p.G646E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Gly646Glu (p.G646E)
( ENST00000644969.2, ENST00000646891.2, ENST00000288602.11, ENST00000496384.7 )
Sensitivity false CIViC Evidence detail
The phase 2a MyPathway study assigned patients wit... BRAF BRAF p.Leu637Gln (p.L637Q)
( ENST00000496384.7, ENST00000288602.11, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Leu637Gln (p.L637Q)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity false CIViC Evidence detail
The phase 2a MyPathway study assigned patients wit... BRAF BRAF p.Pro771Thr (p.P771T)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Pro771Thr (p.P771T)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity false CIViC Evidence detail
The phase 2a MyPathway study assigned patients wit... BRAF BRAF APC BRAF APC Sensitivity false CIViC Evidence detail
The phase 2a MyPathway study assigned patients wit... BRAF BRAF APC BRAF APC Sensitivity false CIViC Evidence detail
The phase 2a MyPathway study assigned patients wit... BRAF BRAF MACF1-BRAF Fusion Sensitivity false CIViC Evidence detail
The phase 2a MyPathway study assigned patients wit... BRAF BRAF WASFL-BRAF Fusion BRAF WASFL-BRAF Fusion Sensitivity false CIViC Evidence detail
The phase 2a MyPathway study assigned patients wit... BRAF BRAF CUX1-BRAF Sensitivity true CIViC Evidence detail
In this double-blind, randomized, placebo-controll... BRAF BRAF V600 BRAF V600 Sensitivity true CIViC Evidence detail
In a phase 2 “basket” study of vemurafenib in BRAF... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
An in vitro study of M229 (a human melanoma cell l... AKT1 AKT1 OVEREXPRESSION AKT1 OVEREXPRESSION Resitance or Non-Reponse false CIViC Evidence detail
An in vitro study of M229 (a human melanoma cell l... AKT3 AKT3 OVEREXPRESSION AKT3 OVEREXPRESSION Resitance or Non-Reponse true CIViC Evidence detail
In a retrospective study of 44 relapsed melanoma p... BRAF BRAF V600E/K AMPLIFICATION BRAF V600E/K AMPLIFICATION Resitance or Non-Reponse true CIViC Evidence detail
In a retrospective study of 44 relapsed melanoma p... NRAS NRAS MUTATION NRAS MUTATION Resitance or Non-Reponse true CIViC Evidence detail
In a retrospective study of 44 relapsed melanoma p... KRAS KRAS MUTATION KRAS MUTATION Resitance or Non-Reponse true CIViC Evidence detail
An in vitro study of WM2664 (a human melanoma cell... PIK3R2 PIK3R2 OVEREXPRESSION PIK3R2 OVEREXPRESSION Resitance or Non-Reponse false CIViC Evidence detail
In a retrospective study of 44 relapsed melanoma p... PREX2 PREX2 R172I PREX2 R172I Resitance or Non-Reponse true CIViC Evidence detail
An in vitro study of M229 (a human melanoma cell l... PTEN PTEN DELETION
( ENST00000371953.8 ) PTEN DELETION
( ENST00000371953.8 )
Resitance or Non-Reponse true CIViC Evidence detail
An in vitro study of M229 (a human melanoma cell l... PIK3CA PIK3CA AMPLIFICATION
( ENST00000263967.4, ENST00000497599.5 ) PIK3CA AMPLIFICATION
( ENST00000263967.4 )
Resitance or Non-Reponse true CIViC Evidence detail
In vitro studies of M229 (a human melanoma cell li... KRAS KRAS AMPLIFICATION
( ENST00000256078.10 ) KRAS AMPLIFICATION
( ENST00000256078.10 )
Resitance or Non-Reponse true CIViC Evidence detail
In a retrospective study of 44 relapsed melanoma p... BRAF BRAF APC BRAF APC Resitance or Non-Reponse true CIViC Evidence detail
In a retrospective study of 44 relapsed melanoma p... BRAF BRAF APC BRAF APC Resitance or Non-Reponse true CIViC Evidence detail
In this Phase 1b study, 129 patients with unresect... BRAF BRAF V600 BRAF V600 Sensitivity true CIViC Evidence detail
A melanoma cell line with AGK-BRAF in-frame fusion... BRAF BRAF AGK-BRAF Resitance or Non-Reponse true CIViC Evidence detail
BRAF-fusion in "pan-negative" melanomas were ident... BRAF BRAF PAPSS1-BRAF Resitance or Non-Reponse true CIViC Evidence detail
A case report of a patient with BRAF L597R mutatio... BRAF BRAF p.Leu637Arg (p.L637R)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Leu637Arg (p.L637R)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
A randomized clinical trial was done with metastat... BRAF BRAF V600 BRAF V600 Sensitivity true CIViC Evidence detail
In the study with a tumor from a patient with meta... BRAF BRAF p.Gly506Val (p.G506V)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Gly506Val (p.G506V)
( ENST00000288602.11, ENST00000646891.2, ENST00000496384.7, ENST00000644969.2 )
Sensitivity false CIViC Evidence detail
RAF inhibitor vemurafenib failed to inhibit ERK si... BRAF BRAF p.Gly506Val (p.G506V)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Gly506Val (p.G506V)
( ENST00000288602.11, ENST00000646891.2, ENST00000496384.7, ENST00000644969.2 )
Sensitivity false CIViC Evidence detail
RAF inhibitor vemurafenib failed to inhibit ERK si... BRAF BRAF p.Asp634Gly (p.D634G)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Asp634Gly (p.D634G)
( ENST00000646891.2, ENST00000496384.7, ENST00000644969.2, ENST00000288602.11 )
Sensitivity false CIViC Evidence detail
Melanoma cell lines harboring the RAC1 P29S hotspo... RAC1 RAC1 p.Pro29Ser (p.P29S)
( ENST00000348035.9, ENST00000356142.4, ENST00000704002.1 ) RAC1 p.Pro29Ser (p.P29S)
( ENST00000348035.9, ENST00000356142.4, ENST00000704002.1 )
Resitance or Non-Reponse true CIViC Evidence detail
In the setting of BRAF(V600E), NF1 loss resulted i... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Resitance or Non-Reponse true CIViC Evidence detail
Mouse xenografts using HT29 cells harboring the BR... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
Cell lines expressing the BRAF V600E mutation resp... BRAF BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 ) BRAF p.Val640Glu (p.V640E)
( ENST00000288602.11, ENST00000496384.7, ENST00000644969.2, ENST00000646891.2 )
Sensitivity true CIViC Evidence detail
NCT ID Status Phase Summary Start date Completion date
NCT01659151 Active, not recruiting Phase 2 Vemurafenib With Lymphodepletion Plus Adoptive Cell Transfer & High Dose IL-2 Metastatic Melanoma August 3, 2012 December 2024
NCT03224767 Active, not recruiting Phase 2 Vemurafenib and Cobimetinib in Treating Patients With BRAF V600E Mutation Positive Craniopharyngioma August 4, 2017 August 2026
NCT04591431 Active, not recruiting Phase 2 The Rome Trial From Histology to Target: the Road to Personalize Target Therapy and Immunotherapy October 7, 2020 June 2025
NCT03101254 Active, not recruiting Phase 1/Phase 2 LY3022855 With BRAF/MEK Inhibition in Patients With Melanoma June 6, 2017 December 31, 2023
NCT02908672 Active, not recruiting Phase 3 A Study of Atezolizumab Plus Cobimetinib and Vemurafenib Versus Placebo Plus Cobimetinib and Vemurafenib in Previously Untreated BRAFv600 Mutation-Positive Patients With Metastatic or Unresectable Locally Advanced Melanoma January 13, 2017 May 15, 2024
NCT01711632 Active, not recruiting Phase 2 BRAF Inhibitor, Vemurafenib, in Patients With Relapsed or Refractory Hairy Cell Leukemia October 2012 October 2025
NCT03498521 Active, not recruiting Phase 2 A Phase II Randomized Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site July 10, 2018 June 9, 2024
NCT01748149 Active, not recruiting Early Phase 1 Vemurafenib in Children With Recurrent/Refractory BRAF Gene V600E (BRAFV600E)-Mutant Gliomas April 29, 2014 December 31, 2025
NCT02314481 Active, not recruiting Phase 2 Deciphering Antitumour Response and Resistance With INtratumour Heterogeneity May 12, 2017 May 2026
NCT03220035 Active, not recruiting Phase 2 Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With BRAF V600 Mutations (A Pediatric MATCH Treatment Trial) November 8, 2017 September 22, 2024
NCT02304809 Active, not recruiting Phase 2 Phase 2 Study Assessing Secured Access to Vemurafenib for Patients With Tumors Harboring BRAF Genomic Alterations October 13, 2014 October 13, 2027
NCT02721459 Active, not recruiting Phase 1 XL888 + Vemurafenib + Cobimetinib for Unresectable BRAF Mutated Stage III/IV Melanoma September 7, 2016 October 2024
NCT03181100 Active, not recruiting Phase 2 Atezolizumab With Chemotherapy in Treating Patients With Anaplastic or Poorly Differentiated Thyroid Cancer July 27, 2017 July 31, 2025
NCT03410875 Active, not recruiting Phase 2 A Phase II Study of the BRAF Inhibitor, Vemurafenib, Plus Obinutuzumab in Patients With Previously Untreated Classical Hairy Cell Leukemia February 9, 2018 January 2025
NCT01787500 Active, not recruiting Phase 1 Vemurafenib, Cetuximab, and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are Metastatic or That Cannot Be Removed by Surgery February 15, 2013 March 31, 2026
NCT02145143 Active, not recruiting N/A Enhancing Radioiodine (RAI) Incorporation Into BRAF Mutant, RAI-Refractory Thyroid Cancers With the BRAF Inhibitor Vemurafenib: A Pilot Study May 2014 May 2025
NCT02036086 Active, not recruiting Phase 2 Study of Neo-adjuvant Use of Vemurafenib Plus Cobimetinib for BRAF Mutant Melanoma With Palpable Lymph Node Metastases August 2015 January 31, 2024
NCT01909453 Active, not recruiting Phase 3 Study Comparing Combination of LGX818 Plus MEK162 Versus Vemurafenib and LGX818 Monotherapy in BRAF Mutant Melanoma September 16, 2013 July 15, 2024
NCT01689519 Completed Phase 3 A Study Comparing Vemurafenib Versus Vemurafenib Plus Cobimetinib in Participants With Metastatic Melanoma January 8, 2013 July 21, 2019
NCT01739764 Completed Phase 4 An Extension (Rollover) Study of Vemurafenib in Participants With BRAF V600 Mutation-Positive Malignancies Previously Enrolled in an Antecedent Vemurafenib Protocol February 19, 2013 February 17, 2020
NCT01765543 Completed Phase 1 A Pharmacokinetics (PK) Study to Investigate the Effect of Rifampin on PK of Vemurafenib (Zelboraf) July 2013 November 2015
NCT01765569 Completed Phase 1 A Pharmacokinetics Study to Investigate the Effect of Vemurafenib on Digoxin in Patients With BRAFV600 Mutation-Positive Metastatic Melanoma July 2013 June 2014
NCT01767623 Completed Phase 1 A Study of The Impact of Severe Hepatic Impairment on the Pharmacokinetics and Safety of Vemurafenib in BRAF V600 Mutation-Positive Cancer Participants August 20, 2013 April 20, 2017
NCT01781026 Completed Phase 2 Phase 2 Study of Neoadjuvant Vemurafenib in Melanoma Patients With Untreated Brain Metastases April 2013 June 2014
NCT00949702 Completed Phase 2 A Study of Vemurafenib in Previously Treated Patients With Metastatic Melanoma September 30, 2009 June 3, 2014
NCT01006980 Completed Phase 3 A Study of Vemurafenib (RO5185426) in Comparison With Dacarbazine in Previously Untreated Patients With Metastatic Melanoma (BRIM 3) January 2010 July 2015
NCT01271803 Completed Phase 1 A Study of Vemurafenib and GDC-0973 (Cobimetinib) in Participants With BRAFV600E Mutation-Positive Metastatic Melanoma February 17, 2011 December 12, 2017
NCT01286753 Completed Phase 2 A Study of Vemurafenib (RO5185426) in Participants With Metastatic or Unresectable Papillary Thyroid Cancer Positive for the BRAF V600 Mutation June 2011 May 2015
NCT01307397 Completed Phase 3 A Study of Vemurafenib in Participants With Metastatic Melanoma March 1, 2011 February 24, 2016
NCT01378975 Completed Phase 2 A Study of Vemurafenib in Metastatic Melanoma Participants With Brain Metastases July 2011 July 2015
NCT01524978 Completed Phase 2 A Study of Vemurafenib in Participants With BRAF V600 Mutation-Positive Cancers April 12, 2012 October 28, 2016
NCT01531361 Completed Phase 1 Vemurafenib With Sorafenib Tosylate or Crizotinib in Treating Patients With Advanced Malignancies With BRAF Mutations February 6, 2012 January 13, 2021
NCT01596140 Completed Phase 1 Vemurafenib in Combination With Everolimus or Temsirolimus With Advanced Cancer December 18, 2012 June 1, 2020
NCT01597908 Completed Phase 3 Dabrafenib Plus Trametinib vs Vemurafenib Alone in Unresectable or Metastatic BRAF V600E/K Cutaneous Melanoma June 4, 2012 April 25, 2019
NCT01603212 Completed Phase 1 Systemic Therapy With Interferon, Interleukin-2 and BRAF Inhibitor July 18, 2013 July 5, 2017
NCT01636622 Completed Phase 1 Study of Vemurafenib, Carboplatin, and Paclitaxel July 9, 2012 April 21, 2020
NCT01636908 Completed N/A Determination of Intratumoral Concentrations of Kinase Inhibitors in Patients With Advanced Solid Malignancies. August 2011 December 1, 2019
NCT01656642 Completed Phase 1 A Phase 1b Study of Atezolizumab in Combination With Vemurafenib or Vemurafenib Plus Cobimetinib in Participants With BRAFV600-Mutation Positive Metastatic Melanoma August 13, 2012 March 25, 2020
NCT01657591 Completed Phase 1 Study of XL888 With Vemurafenib for Patients With Unresectable BRAF Mutated Stage III/IV Melanoma July 27, 2012 September 21, 2021
NCT01667419 Completed Phase 3 A Study of Vemurafenib Adjuvant Therapy in Participants With Surgically Resected Cutaneous BRAF-Mutant Melanoma September 24, 2012 July 13, 2018
NCT01673737 Completed Phase 1 A Phase I/Ib Trial for the Evaluation of SAR260301 in Monotherapy or in Combination With Vemurafenib in Patients With Various Advanced Cancer August 2012 February 2015
NCT01673854 Completed Phase 2 Phase II Safety Study of Vemurafenib Followed by Ipilimumab in Subjects With V600 BRAF Mutated Advanced Melanoma September 13, 2012 May 12, 2015
NCT01844674 Completed Phase 1 A Study on the Effect of Vemurafenib on the Pharmacokinetics of a Single Dose of Tizanidine in Patients With BRAFV600 Mutation-Positive Metastatic Malignancies September 2, 2013 August 26, 2014
NCT01849666 Completed Phase 1 A Study of the Effect of Vemurafenib on the Pharmacokinetics of Phenprocoumon in Patients With BRAFV600 Mutation-Positive Metastatic Malignancy September 2013 April 2014
NCT01851824 Completed Phase 1 A Study of the Effect of Vemurafenib on the Pharmacokinetics of Acenocoumarol in Patients With BRAFV600 Mutation-Positive Metastatic Malignancy August 2013 June 2014
NCT01910181 Completed Phase 1 A Study of Vemurafenib (Zelboraf) in Chinese Participants With BRAF V600 Mutation-Positive Unresectable or Metastatic Melanoma August 17, 2013 April 20, 2018
NCT01943422 Completed Phase 1 Safety and Efficacy Study of Vemurafenib and High-dose Interferon Alfa-2b in Melanoma October 2013 December 2016
NCT01959633 Completed Phase 1/Phase 2 Vemurafenib Plus Cobimetinib Plus PEG-interferon in Advanced Melanoma Patients Harboring the V600BRAF Mutation April 3, 2014 March 26, 2018
NCT02091141 Completed Phase 2 My Pathway: A Study Evaluating Herceptin/Perjeta, Tarceva, Zelboraf/Cotellic, Erivedge, Alecensa, and Tecentriq Treatment Targeted Against Certain Molecular Alterations in Participants With Advanced Solid Tumors April 14, 2014 May 24, 2023
NCT02164916 Completed Phase 2 S1406 Phase II Study of Irinotecan and Cetuximab With or Without Vemurafenib in BRAF Mutant Metastatic Colorectal Cancer November 2014 November 19, 2020
NCT02291289 Completed Phase 2 A Study of Biomarker-Driven Therapy in Metastatic Colorectal Cancer (mCRC) April 17, 2015 March 24, 2021
NCT02354690 Completed Phase 1/Phase 2 Vemurafenib and TIL Therapy for Metastatic Melanoma November 2014 December 31, 2018
NCT02441465 Completed Phase 1 Bioavailability Study of Vemurafenib in Participants With BRAF^V600 Mutation-Positive Malignancies August 13, 2015 January 9, 2017
NCT02456701 Completed Phase 1 Enhancing Radioiodine Incorporation Into BRAF Mutant Thyroid Cancers With the Combination of Vemurafenib and KTN3379 June 2015 October 13, 2016
NCT02608034 Completed Phase 1 A Study to Investigate the Effect of Itraconazole and Rifampin on Pharmacokinetics (PK) of Vemurafenib at Steady State May 26, 2016 September 10, 2018
NCT02768207 Completed Phase 2 A Study to Detect V-Raf Murine Sarcoma Viral Oncogene Homolog B1 (BRAF) V600 Mutation on Cell-Free Deoxyribonucleic Acid (cfDNA) From Plasma in Participants With Advanced Melanoma May 23, 2016 June 27, 2019
NCT02902029 Completed Phase 2 Evaluating the Efficacy and Safety of a Sequencing Schedule of Cobimetinib Plus Vemurafenib Followed by Immunotherapy With an Anti- PD-L1 Antibody in Patients With Unresectable or Metastatic BRAF V600 Mutant Melanoma November 2016 March 2024
NCT03013491 Completed Phase 1/Phase 2 PROCLAIM-CX-072: A Trial to Find Safe and Active Doses of an Investigational Drug CX-072 for Patients With Solid Tumors or Lymphomas January 2017 October 6, 2021
NCT03139513 Completed A Study of Adult Participants With BRAF V600 Mutation-Positive Advanced Melanoma Treated With Cobimetinib (Cotellic®) During the French Early Access Program (Temporary Authorization for Use [TAU]) October 27, 2016 August 22, 2018
NCT03625141 Completed Phase 2 A Study Evaluating the Safety and Efficacy of Cobimetinib Plus Atezolizumab in BRAFV600 Wild-type Melanoma With Central Nervous System Metastases and Cobimetinib Plus Atezolizumab and Vemurafenib in BRAFV600 Mutation-positive Melanoma With Central Nervous System Metastases December 13, 2018 April 13, 2023
NCT04462471 Completed Phase 1 Vemurafenib Plus Copanlisib in Radioiodine-Refractory (RAIR) Thyroid Cancers June 26, 2020 September 29, 2023
NCT04790448 Completed Phase 1/Phase 2 Efficacy of VIC Regimen in BRAF Mutant Metastatic Colorectal Cancer July 27, 2020 December 31, 2021
NCT05260684 Completed Comparative Effectiveness of Targeted Therapies in BRAF Positive Metastatic Melanoma in the US January 17, 2022 December 31, 2023
NCT03178552 Recruiting Phase 2/Phase 3 A Study to Evaluate the Efficacy and Safety of Multiple Targeted Therapies as Treatments for Participants With Non-Small Cell Lung Cancer (NSCLC) September 22, 2017 August 3, 2028
NCT05068752 Recruiting Phase 2 Phase II Trial of Vemurafenib and Sorafenib in Pancreatic Cancer October 28, 2021 December 30, 2024
NCT05525858 Recruiting KPMNG Study of MOlecular Profiling Guided Therapy Based on Genomic Alterations in Advanced Solid Tumors II September 28, 2022 September 2025
NCT01638676 Recruiting Phase 1/Phase 2 A Phase I/II Trial of Vemurafenib and Metformin to Melanoma Patients July 2012 June 2027
NCT05159245 Recruiting Phase 2 The Finnish National Study to Facilitate Patient Access to Targeted Anti-cancer Drugs December 10, 2021 November 25, 2026
NCT03768063 Recruiting Phase 3 A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study February 28, 2019 July 5, 2028
NCT04551521 Recruiting Phase 2 CRAFT: The NCT-PMO-1602 Phase II Trial October 13, 2021 June 30, 2025
NCT05233332 Recruiting Phase 2 Study of HL-085 and Vemurafinib in Metastatic Colorectal Cancer (mCRC) February 24, 2022 July 20, 2024
NCT05768178 Recruiting Phase 2/Phase 3 DETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers. March 1, 2023 October 2029
NCT03554083 Recruiting Phase 2 Vemurafenib, Cobimetinib, Atezolizumab, and Tiragolumab in Treating Patients With High-Risk Stage III Melanoma October 5, 2018 June 29, 2025
NCT05263453 Recruiting Phase 2 HL-085+Vemurafenib to Treat Advanced Melanoma Patients With BRAF V600E/K Mutation September 6, 2021 December 31, 2024
NCT03585686 Recruiting Phase 2 A Combination of Vemurafenib, Cytarabine and 2-chlorodeoxyadenosine in Children With LCH and BRAF V600E Mutation June 26, 2018 December 2023
NCT03781219 Recruiting Phase 1 A PhaseI Study of HL-085 Plus Vemurafenib in Solid Tumor With BRAF V600 Mutation July 1, 2018 December 1, 2023
NCT04943198 Recruiting Phase 2 Optimization of the Time and Dosage of Vemurafenib in BRAF Positive Juvenile Patients With Refractory Histiocytosis April 1, 2021 June 23, 2026
NCT06440850 Recruiting Phase 2 Vemurafenib and Cobimetinib for the Treatment of Patients With High Risk Differentiated Thyroid Carcinoma With BRAFV600E Mutation November 30, 2024 November 30, 2026
NCT03155620 Recruiting Phase 2 Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial) July 31, 2017 September 30, 2027
NCT03430947 Terminated Phase 2 Vemurafenib Plus Cobimetinib After Radiosurgery in Patients With BRAF-mutant Melanoma Brain Metastases July 1, 2018 February 10, 2023
NCT04801966 Terminated N/A Safety and Oversight of the Individually Tailored Treatment Approach: A Novel Pilot Study September 23, 2021 December 30, 2022
NCT02818023 Terminated Phase 1 Dose-seeking Study of Pembrolizumab Plus Vemurafenib and Cobimetinib Advanced Melanoma July 13, 2016 April 23, 2021
NCT01616199 Terminated Phase 1/Phase 2 Study of PX-866 and Vemurafenib in Patients With Advanced Melanoma August 2012 March 2015
NCT01611675 Terminated Phase 1 Leflunomide+Vemurafenib in V600 Mutant Met. Melanoma July 2012 January 2014
NCT01586195 Terminated Phase 2 Study Of Zelboraf (Vemurafenib) in Patients With Locally-Advanced, Unresectable, Stage IIIc Or Metastatic Melanoma and Activating Exon 15 BRAF Mutations Other Than V600E October 31, 2011 April 30, 2015
NCT01585415 Terminated Phase 1 Vemurafenib and White Blood Cell Therapy for Advanced Melanoma April 9, 2012 July 21, 2016
NCT03224208 Terminated Phase 2 Vemurafenib Plus Cobimetinib in Advanced or Metastatic Melanoma Patients May 17, 2018 January 8, 2021
NCT01519323 Terminated Phase 1 BRIM-P: A Study of Vemurafenib in Pediatric Patients With Stage IIIC or Stage IV Melanoma Harboring BRAFV600 Mutations January 2013 December 2015
NCT01495988 Terminated Phase 2 Trial of Vemurafenib/Cobimetinib With or Without Bevacizumab in Patients With Stage IV BRAFV600 Mutant Melanoma August 2013 June 2016
NCT01754376 Terminated Phase 2 Combined BRAF-Targeted Therapy & Immunotherapy for Melanoma January 2013 March 2016
NCT01474551 Terminated Phase 2 Vemurafenib (R05185426) in Poor Performance Status Patients With Unresectable Locally Advanced or Metastatic Melanoma Harboring a V600E/K Mutation November 2011 March 2013
NCT01942993 Terminated Phase 2 The Effects of Treatment With Vemurafenib on the Immune System in Advanced Melanoma September 2013 November 2015
NCT03878524 Terminated Phase 1 Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial April 1, 2020 December 10, 2020
NCT01826448 Terminated Phase 1 A Phase 1b Open Label, Dose Escalation Study of PLX3397 in Combination With Vemurafenib in V600-mutated BRAF Melanoma November 5, 2013 September 22, 2014
NCT02050321 Terminated Phase 2 A Phase II Study of Vemurafenib Combined With Acitretin in Patients With Advanced Melanoma December 2013 July 2015
NCT02052193 Terminated Phase 2 Evaluation of Photosensitivity in Dabrafenib or Vemurafenib Treated Metastatic Melanoma Patients - a Phase IIa/IIb Study January 2014 December 15, 2014
NCT01813214 Terminated Phase 2 The Effects of Vemurafenib + Cobimetinib on Immunity in Patients With Melanoma March 2013 December 2016
NCT02230306 Terminated Phase 2 Phase II Study of Cobimetinib in Combination With Vemurafenib in Active Melanoma Brain Metastases February 2015 March 2016
NCT01400451 Terminated Phase 1 Ph I Ipilimumab Vemurafenib Combo in Patients With v-Raf Murine Sarcoma Viral Oncogene Homolog B1 (BRAF) November 2011 December 2013
NCT02303951 Terminated Phase 2 Neoadjuvant Vemurafenib + Cobimetinib + Atezolizumab in Melanoma: NEO-VC January 22, 2015 May 14, 2020
NCT01835184 Terminated Phase 1 Cabozantinib-S-Malate and Vemurafenib in Treating Patients With Solid Tumors or Melanoma That is Metastatic or That Cannot Be Removed By Surgery May 2013
NCT02638428 Unknown status Phase 2 Genomics-Based Target Therapy for Children With Relapsed or Refractory Malignancy December 2015 December 2023
NCT03727763 Unknown status Phase 2 Cetuximab and Vemurafenib Plus FOLFIRI for BRAF V600E Mutated Advanced Colorectal Cancer (IMPROVEMENT) October 8, 2018 December 31, 2022
NCT03239015 Unknown status Phase 2 Efficacy and Safety of Precision Therapy in Refractory Tumor January 1, 2017 December 31, 2023
NCT05238831 Withdrawn Early Phase 1 SMMART Adaptive Clinical Treatment (ACT) Trial January 30, 2023 May 31, 2026
NCT01974258 Withdrawn Phase 1 Safety, Tolerability, and Pharmacokinetics of Onartuzumab Combined With Vemurafenib and/or Cobimetinib in Cancer Patients February 2014 July 2014
NCT01843738 Withdrawn Phase 1 Radiation Use During Vemurafenib Treatment June 2017 August 2022
NCT01765556 Withdrawn Phase 1 A Pharmacokinetics Study to Investigate the Effect of Ketoconazole on Vemurafenib in Patients With BRAFV600 Mutation-Positive Metastatic Melanoma October 2013 October 2013
NCT02145910 Withdrawn Phase 1 Vemurafenib Combined With Whole Brain Radiation Therapy or Radiosurgery in Patients With BRAF Mutation-Positive Melanoma and Brain Metastases
NCT02427893 Withdrawn Phase 3 Trial of Vemurafenib and Cobimetinib in Patients With Advanced BRAFV600 Mutant Melanoma August 2015 November 2016