NRAS NRAS proto-oncogene, GTPase

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Information
Clinical Significance
Ranking
Frequency
Disease area statistics
Locus Zoom
Variants
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Information

Symbol: NRAS
Type: protein-coding
Description: NRAS proto-oncogene, GTPase
Entrez Gene ID: 4893
Genome: hg19
Position: chr1:115,247,090-115,259,392
Genome: hg38
Position: chr1:114,704,469-114,716,771
MIM: 164790 OMIM
HGNC: HGNC:7989 HGNC
Ensembl: ENSG00000213281 Ensembl
Links: NCBI Gene Cards OncoKB

Clinical Significance

	MGeND	ClinVar
Pathogenic	11	40
Likely pathogenic	6	38
Benign	0	54
Likely benign	0	168
Conflicting classifications of pathogenicity	0	46
not provided	58	0
other	1	0
Uncertain significance	6	248

Ranking

	ClinVar
	0
	0
	92
	394
	34

Frequency

EXAC_EAS

EXAC_EAS

HGVD

HGVD

TOMMO

TOMMO

Gene

Position

EXAC_EAS

EXAC_EAS

HGVD

HGVD

TOMMO

TOMMO

Gene

Position

Disease area statistics

Locus Zoom

Variants

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Target data	:	MGeND data only
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Variant name	Gene	AA change	CDS	Japanese frequency	TogoVar	MGeND				Genome	ClinVar			CIViC evidence	DisGeNET entry	COSMIC occurrence	Prediction
Variant name	Gene	AA change	CDS	Japanese frequency	TogoVar	Entry	Origin	Type	Annotation	Genome	Entry	Origin	Annotation	CIViC evidence	DisGeNET entry	COSMIC occurrence	Prediction

Search Word

Target data	:	MGeND data only
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Name	MGeND				Type	Genome	Size	Chromosome	Start	Stop	Ref	Alt	ClinVar	Origin	Entry	CIViC evidence	DisGeNET entry
Name	Entry	Origin	Type	Annotation	Type	Genome	Size	Chromosome	Start	Stop	Ref	Alt	ClinVar	Origin	Entry	CIViC evidence	DisGeNET entry

Search Word

Target data	:	MGeND data only
Category	:
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Name	MGeND				Type	Genome	Gene symbol	Chromosome	Genomic start	Genomic stop	Strand	Ref	Alt	ClinVar	Origin	Entry	CIViC evidence	DisGeNET entry
Name	Entry	Origin	Type	Annotation	Type	Genome	Gene symbol	Chromosome	Genomic start	Genomic stop	Strand	Ref	Alt	ClinVar	Origin	Entry	CIViC evidence	DisGeNET entry

Type	ID
SYNONYM	ALPS4
SYNONYM	CMNS
SYNONYM	KRAS
SYNONYM	N-ras
SYNONYM	NCMS
SYNONYM	NRAS1
SYNONYM	NS6
MIM	164790 OMIM
HGNC	HGNC:7989 HGNC
Ensembl	ENSG00000213281 Ensembl
AllianceGenome	HGNC:7989

Descrption	Source	Links

ID	Genome	Chromosome	Start	End	Length
ENST00000369535.5	hg38	chr1	114,704,469	114,716,771	12,303
ENST00000369535.5	hg19	chr1	115,247,090	115,259,392	12,303

Key	Value
strand	-
UniProt	OG
start	115,247,084
Vogelstein	OG
Gene Symbol	NRAS
Entrez GeneId	4,893
Chr Band	1p13.2
end	115,259,514
chr	chr1
Name	neuroblastoma RAS viral (v-ras) oncogene homolog

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