Annotation Detail
Information
- Associated Genes
- BRAF
- Associated Variants
-
BRAF p.Asp634Gly (p.D634G)
(
ENST00000288602.11,
ENST00000496384.7,
ENST00000644969.2,
ENST00000646891.2 )
BRAF p.Asp634Gly (p.D634G) ( ENST00000646891.2, ENST00000496384.7, ENST00000644969.2, ENST00000288602.11 ) - Associated Disease
- Solid Tumor
- Source Database
- CIViC Evidence
- Description
- RAF inhibitor vemurafenib failed to inhibit ERK signaling in tumor cells and NIH3T3 that express class 3 BRAF mutations (G466V, G466E, D594G, D594N, and G596R).
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/7556
- Gene URL
- https://civic.genome.wustl.edu/links/genes/5
- Variant URL
- https://civic.genome.wustl.edu/links/variants/611
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Solid Tumor
- Evidence Direction
- Does Not Support
- Drug
- Vemurafenib
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 28783719
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Vemurafenib | Sensitivity | false |