Annotation Detail
Information
- Associated Genes
- PIK3R2
- Associated Variants
-
PIK3R2 OVEREXPRESSION
PIK3R2 OVEREXPRESSION - Associated Disease
- melanoma
- Source Database
- CIViC Evidence
- Description
- An in vitro study of WM2664 (a human melanoma cell line) endogenously expressing wildtype PIK3R2 and BRAF V600D (a known BRAF inhibitor sensitizing mutation) found that cells induced to stably over-express PIK3R2 (via viral transduction with additional copies of wildtype PIK3R2) were not significantly more resistant to vemurafenib (a BRAFi) than cells transduced with empty vectors, which served as the negative controls.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/6266
- Gene URL
- https://civic.genome.wustl.edu/links/genes/4290
- Variant URL
- https://civic.genome.wustl.edu/links/variants/2363
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Melanoma
- Evidence Direction
- Does Not Support
- Drug
- Vemurafenib
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 24265155
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Vemurafenib | Resitance or Non-Reponse | false |