AKT3 OVEREXPRESSION Detail (hg38) (AKT3)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr1:243,651,535-244,014,381 View the variant detail on this assembly version. |
| hg38 | chr1:243,488,233-243,851,079 |
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
| Type | Database | ID | Link |
|---|---|---|---|
| Gene | MIM | ||
| HGNC | |||
| Ensembl | |||
| NCBI | |||
| Gene Cards | |||
| OncoKB |
| Type | Database | ID | Link |
|---|---|---|---|
| Variant | TogoVar | ||
| COSMIC | |||
| MONDO |
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
| Disease | Drug | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| breast cancer | Akt Inhibitor MK2206 | D |
Predictive
|
Supports
|
Resistance |
N/A
|
4 | 27297869 | Detail |
| triple-receptor negative breast cancer | Pan-AKT Kinase Inhibitor GSK690693 | E |
Predictive
|
Supports
|
Sensitivity/Response |
N/A
|
4 | 24335962 | Detail |
| melanoma | Vemurafenib | D |
Predictive
|
Supports
|
Resistance | Somatic | 2 | 24265155 | Detail |
DisGeNET
[No Data.]
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| Upregulation of AKT3 due to epigenetic reprogramming may confer acquired resistance to AKT inhibitor... | CIViC Evidence | Detail |
| AKT3 was found to be preferentially required for the proliferation and tumor growth of TNBC. It was ... | CIViC Evidence | Detail |
| An in vitro study of M229 (a human melanoma cell line) endogenously expressing wildtype AKT3 and BRA... | CIViC Evidence | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- Genome
- hg38
- Position
- chr1:243,488,233-243,851,079
- Variant Type
- cnv
- Variant (CIViC) (CIViC Variant)
- OVEREXPRESSION
- Variant URL (CIViC Variant)
- https://civic.genome.wustl.edu/links/variants/1301
Genome browser