Annotation Detail
Information
- Associated Genes
- AKT3
- Associated Variants
-
AKT3 OVEREXPRESSION
AKT3 OVEREXPRESSION - Associated Disease
- triple-receptor negative breast cancer
- Source Database
- CIViC Evidence
- Description
- AKT3 was found to be preferentially required for the proliferation and tumor growth of TNBC. It was found to be upregulated in a set of TNBC cell lines compared to other breast cancer types. Depletion of AKT3 in TNBC sensitizes cells to the pan-Akt inhibitor GSK690693. It was found that depletion of Akt3 potentially inhibits the growth of TNBC cell lines in three-dimensional (3D) spheroid cultures and in mouse xenograft models, which imply that therapeutic targeting of AKT3 may provide a new treatment option for TNBCs.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1923
- Gene URL
- https://civic.genome.wustl.edu/links/genes/7936
- Variant URL
- https://civic.genome.wustl.edu/links/variants/1301
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Triple-receptor Negative Breast Cancer
- Evidence Direction
- Supports
- Drug
- Pan-AKT Kinase Inhibitor GSK690693
- Evidence Level
- E
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 24335962
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Pan-AKT Kinase Inhibitor GSK690693 | Sensitivity | true |