Annotation Detail
Information
- Associated Genes
- AKT3
- Associated Variants
-
AKT3 OVEREXPRESSION
AKT3 OVEREXPRESSION - Associated Disease
- breast cancer
- Source Database
- CIViC Evidence
- Description
- Upregulation of AKT3 due to epigenetic reprogramming may confer acquired resistance to AKT inhibitor (MK2206) in breast cancer preclinical model.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1922
- Gene URL
- https://civic.genome.wustl.edu/links/genes/7936
- Variant URL
- https://civic.genome.wustl.edu/links/variants/1301
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Breast Cancer
- Evidence Direction
- Supports
- Drug
- Akt Inhibitor MK2206
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 27297869
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Akt Inhibitor MK2206 | Resitance or Non-Reponse | true |