Annotation Detail
Information
- Associated Genes
- ARAF
- Associated Variants
-
ARAF p.Ser490Thr (p.S490T)
(
ENST00000377045.9 )
ARAF p.Ser490Thr (p.S490T) ( ENST00000377045.9 ) - Associated Disease
- colorectal cancer
- Source Database
- CIViC Evidence
- Description
- Phase 1b study of vemurafenib, cetuximab and irinotecan in 19 BRAF V600E mutant colorectal cancer patients. cfDNA panel sequencing was performed in 10 patients after disease progression. One patient had an acquired ARAF S490T mutation that was not identified before treatment initiation.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1905
- Gene URL
- https://civic.genome.wustl.edu/links/genes/3
- Variant URL
- https://civic.genome.wustl.edu/links/variants/825
- Rating
- 1
- Evidence Type
- Predictive
- Disease
- Colorectal Cancer
- Evidence Direction
- Supports
- Drug
- Irinotecan,Cetuximab,Vemurafenib
- Evidence Level
- C
- Clinical Significance
- Resistance
- Pubmed
- 27729313
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Cetuximab | Resitance or Non-Reponse | true |
| Irinotecan | Resitance or Non-Reponse | true |
| Vemurafenib | Resitance or Non-Reponse | true |