Imatinib

Search with Google Search with Bing

Information
Drug Name
Imatinib
Description
Entry(CIViC)
127
CIViC
Disease Mutation EL ET ED CS VO TR Pubmed Links
endometrial cancer KIT EXPRESSION KIT EXPRESSION C Predictive Supports Sensitivity/Response N/A 2 18607592 Detail
endometrial cancer KIT EXPRESSION KIT EXPRESSION C Predictive Supports Sensitivity/Response N/A 2 16487996 Detail
gastrointestinal stromal tumor KIT EXON 9 MUTATION KIT EXON 9 MUTATION B Predictive Supports Sensitivity/Response Somatic 4 16624552 Detail
melanoma KIT MUTATION KIT MUTATION B Predictive Supports Sensitivity/Response Somatic 3 21690468 Detail
chronic myeloid leukemia BCL2L11 DELETION POLYMORPHISM BCL2L11 DELETION POLYMORPHISM B Predictive Supports Resistance Common Germline 4 22426421 Detail
gastrointestinal stromal tumor PDGFRA p.Ile843del (p.I843del), ENSG00000282278 p.Ile603del (p.I603del)
( ENST00000257290.10 ) PDGFRA p.Ile843del (p.I843del), ENSG00000282278 p.Ile603del (p.I603del)
( ENST00000257290.10 )
D Predictive Supports Sensitivity/Response Somatic 2 14645423 Detail
acute lymphoblastic leukemia PDGFRB EBF1-PDGFRB C Predictive Supports Sensitivity/Response Somatic 3 23835704 Detail
chronic leukemia KIT p.Met542Leu (p.M542L)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Met542Leu (p.M542L)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
C Predictive Supports Sensitivity/Response Somatic 2 25015329 Detail
myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1 PDGFRA FIP1L1-PDGFRA B Predictive Supports Sensitivity/Response Somatic 4 14504092 Detail
myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1 PDGFRA FIP1L1-PDGFRA A Predictive Supports Sensitivity/Response Somatic 3 12660384 Detail
myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1 PDGFRA FIP1L1-PDGFRA T674I C Predictive Supports Resistance Somatic 2 12660384 Detail
mucosal melanoma KIT AMPLIFICATION
( ENST00000288135.6 ) KIT AMPLIFICATION
( ENST00000288135.6 )
B Predictive Supports Resistance N/A 3 23775962 Detail
myeloproliferative neoplasm PDGFRB PDGFRB FUSIONS PDGFRB PDGFRB FUSIONS A Predictive Supports Sensitivity/Response Somatic 4 16960151 Detail
gastrointestinal stromal tumor PDGFRA p.Asp842Val (p.D842V), ENSG00000282278 p.Asp602Val (p.D602V)
( ENST00000257290.10 ) PDGFRA p.Asp842Val (p.D842V), ENSG00000282278 p.Asp602Val (p.D602V)
( ENST00000257290.10 )
B Predictive Supports Resistance Somatic 4 15928335 Detail
gastrointestinal stromal tumor PDGFRA p.Asp842Val (p.D842V), ENSG00000282278 p.Asp602Val (p.D602V)
( ENST00000257290.10 ) PDGFRA p.Asp842Val (p.D842V), ENSG00000282278 p.Asp602Val (p.D602V)
( ENST00000257290.10 )
B Predictive Supports Resistance Somatic 4 16954519 Detail
myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1 PDGFRA FIP1L1-PDGFRA C Predictive Supports Sensitivity/Response Somatic 3 24456122 Detail
myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1 PDGFRA TNKS2-PDGFRA C Predictive Supports Sensitivity/Response Somatic 3 25658984 Detail
melanoma PDGFRA p.Pro577Ser (p.P577S), ENSG00000282278 c.1018-9C>T
( ENST00000257290.10 ) PDGFRA p.Pro577Ser (p.P577S), ENSG00000282278 c.1018-9C>T
( ENST00000257290.10 )
D Predictive Supports Sensitivity/Response Somatic 3 24132921 Detail
melanoma PDGFRA p.Arg841Lys (p.R841K), ENSG00000282278 p.Arg601Lys (p.R601K)
( ENST00000257290.10 ) PDGFRA p.Arg841Lys (p.R841K), ENSG00000282278 p.Arg601Lys (p.R601K)
( ENST00000257290.10 )
D Predictive Supports Sensitivity/Response 3 24132921 Detail
melanoma PDGFRA p.His845Tyr (p.H845Y), ENSG00000282278 p.His605Tyr (p.H605Y)
( ENST00000257290.10 ) PDGFRA p.His845Tyr (p.H845Y), ENSG00000282278 p.His605Tyr (p.H605Y)
( ENST00000257290.10 )
D Predictive Supports Sensitivity/Response Somatic 3 24132921 Detail
melanoma PDGFRA p.Gly853Asp (p.G853D), ENSG00000282278 p.Gly613Asp (p.G613D)
( ENST00000257290.10 ) PDGFRA p.Gly853Asp (p.G853D), ENSG00000282278 p.Gly613Asp (p.G613D)
( ENST00000257290.10 )
D Predictive Supports Sensitivity/Response Somatic 3 24132921 Detail
chronic myeloid leukemia ABL1 p.Phe378Val (p.F378V)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Phe378Val (p.F378V)
( ENST00000318560.6, ENST00000372348.9 )
D Predictive Supports Resistance Somatic 2 19075254 Detail
chronic myeloid leukemia ABL1 p.Phe378Val (p.F378V)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Phe378Val (p.F378V)
( ENST00000318560.6, ENST00000372348.9 )
C Predictive Supports Resistance Somatic 15930265 Detail
acute myeloid leukemia ABL1 BCR-ABL D Predictive Supports Resistance Somatic 3 12476305 Detail
chronic myeloid leukemia ABL1 p.Glu274Lys (p.E274K) ABL1 p.Glu274Lys (p.E274K) D Predictive Supports Resistance Somatic 4 15194504 Detail
chronic myeloid leukemia ABL1 p.Thr334Ile (p.T334I) ABL1 p.Thr334Ile (p.T334I) B Predictive Supports Resistance Somatic 4 20537386 Detail
chronic myeloid leukemia ABL1 p.Thr334Ile (p.T334I) ABL1 p.Thr334Ile (p.T334I) D Predictive Supports Resistance Somatic 4 15194504 Detail
gastrointestinal stromal tumor KIT UNKNOWN KIT W557_V559insC C Predictive Supports Sensitivity/Response Somatic 2 18955451 Detail
gastrointestinal stromal tumor KIT UNKNOWN KIT W557_V559insC C Predictive Does Not Support Sensitivity/Response Somatic 1 18955451 Detail
cancer KIT p.Asn823His (p.N823H)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Asn823His (p.N823H)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
D Predictive Does Not Support Resistance Somatic 2 14645423 Detail
cancer KIT p.Asn823Lys (p.N823K)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687246.1, ENST00000687109.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Asn823Lys (p.N823K)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
D Predictive Does Not Support Sensitivity/Response Somatic 2 14645423 Detail
cancer KIT p.Asp817Val (p.D817V)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Asp817Val (p.D817V)
( ENST00000686011.1, ENST00000687109.1, ENST00000288135.6, ENST00000412167.7, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
D Predictive Supports Resistance Somatic 2 14645423 Detail
cancer PDGFRA p.Val561Asp (p.V561D), ENSG00000282278 c.1018-56T>A
( ENST00000257290.10 ) PDGFRA p.Val561Asp (p.V561D), ENSG00000282278 c.1018-56T>A
( ENST00000257290.10 )
D Predictive Does Not Support Resistance Somatic 2 14645423 Detail
cancer PDGFRA D842_H845DELDIMH PDGFRA D842_H845DELDIMH D Predictive Does Not Support Resistance Somatic 2 14645423 Detail
cancer PDGFRA p.Asp842Val (p.D842V), ENSG00000282278 p.Asp602Val (p.D602V)
( ENST00000257290.10 ) PDGFRA p.Asp842Val (p.D842V), ENSG00000282278 p.Asp602Val (p.D602V)
( ENST00000257290.10 )
D Predictive Supports Resistance Somatic 2 14645423 Detail
gastrointestinal stromal tumor KIT UNKNOWN KIT W557_V559insC C Predictive Supports Sensitivity/Response Somatic 1 18955451 Detail
gastrointestinal stromal tumor KIT EXON 9 MUTATION KIT EXON 9 MUTATION B Predictive Supports Sensitivity/Response Somatic 3 14645423 Detail
cancer KIT p.Val561Gly (p.V561G)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Val561Gly (p.V561G)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
D Predictive Does Not Support Resistance Somatic 2 14645423 Detail
gastrointestinal stromal tumor KIT EXON 11 MUTATION KIT EXON 11 MUTATION B Predictive Supports Sensitivity/Response Somatic 4 18955451 Detail
cancer KIT p.Lys643Glu (p.K643E)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Lys643Glu (p.K643E)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
D Predictive Does Not Support Resistance Somatic 2 14645423 Detail
gastrointestinal stromal tumor PDGFRA p.Val561Asp (p.V561D), ENSG00000282278 c.1018-56T>A
( ENST00000257290.10 ) PDGFRA p.Val561Asp (p.V561D), ENSG00000282278 c.1018-56T>A
( ENST00000257290.10 )
C Predictive Supports Sensitivity/Response Somatic 1 18955451 Detail
gastrointestinal stromal tumor KIT MUTATION KIT MUTATION C Predictive Supports Sensitivity/Response Somatic 2 14645423 Detail
gastrointestinal stromal tumor KIT EXON 9 MUTATION KIT EXON 9 MUTATION B Predictive Supports Reduced Sensitivity Somatic 2 18955451 Detail
gastrointestinal stromal tumor PDGFRA p.Asp842Val (p.D842V), ENSG00000282278 p.Asp602Val (p.D602V)
( ENST00000257290.10 ) PDGFRA p.Asp842Val (p.D842V), ENSG00000282278 p.Asp602Val (p.D602V)
( ENST00000257290.10 )
C Predictive Supports Resistance Somatic 2 14645423 Detail
gastrointestinal stromal tumor KIT EXPRESSION KIT EXPRESSION B Predictive Supports Sensitivity/Response Somatic 2 18955451 Detail
cancer KIT p.Trp558_Lys559del (p.W558_K559del)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1, ENST00000687109.1, ENST00000687246.1 ) KIT p.Trp558_Lys559del (p.W558_K559del)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
D Predictive Does Not Support Resistance Somatic 2 14645423 Detail
cancer KIT p.Ala503_Tyr504dup (p.A503_Y504dup)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Ala503_Tyr504dup (p.A503_Y504dup)
( ENST00000690543.1, ENST00000692783.1, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000288135.6 )
D Predictive Does Not Support Resistance Somatic 2 14645423 Detail
gastrointestinal stromal tumor PDGFRA MUTATION PDGFRA MUTATION C Predictive Does Not Support Sensitivity/Response Somatic 1 18955451 Detail
gastrointestinal stromal tumor KIT p.Asp580del (p.D580del)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Asp580del (p.D580del)
( ENST00000412167.7, ENST00000288135.6, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
C Predictive Supports Sensitivity/Response Somatic 3 14645423 Detail
gastrointestinal stromal tumor KIT p.Val655Ala (p.V655A)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Val655Ala (p.V655A)
( ENST00000689832.1, ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
D Predictive Supports Resistance Somatic 3 16954519 Detail
acute myeloid leukemia ABL1 BCR-ABL A Predictive Supports Sensitivity/Response Somatic 5 12476305 Detail
chronic myeloid leukemia ABL1 BCR-ABL A Predictive Supports Sensitivity/Response Somatic 5 20537386 Detail
chronic myeloid leukemia ABL1 p.Met263Val (p.M263V)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Met263Val (p.M263V)
( ENST00000318560.6, ENST00000372348.9 )
C Predictive Supports Sensitivity/Response Somatic 15930265 Detail
chronic myeloid leukemia ABL1 p.Leu267Val (p.L267V)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Leu267Val (p.L267V)
( ENST00000318560.6, ENST00000372348.9 )
D Predictive Supports Resistance Somatic 2 19075254 Detail
chronic myeloid leukemia ABL1 p.Gly269Glu (p.G269E)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Gly269Glu (p.G269E)
( ENST00000318560.6, ENST00000372348.9 )
D Predictive Supports Resistance Somatic 3 19075254 Detail
chronic myeloid leukemia ABL1 p.Gly269Glu (p.G269E)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Gly269Glu (p.G269E)
( ENST00000318560.6, ENST00000372348.9 )
C Predictive Supports Resistance Somatic 15930265 Detail
chronic myeloid leukemia ABL1 p.Gln271His (p.Q271H)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Gln271His (p.Q271H)
( ENST00000318560.6, ENST00000372348.9 )
D Predictive Supports Sensitivity/Response Somatic 3 19075254 Detail
chronic myeloid leukemia ABL1 p.Tyr272Phe (p.Y272F)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Tyr272Phe (p.Y272F)
( ENST00000318560.6, ENST00000372348.9 )
D Predictive Supports Resistance Somatic 2 19075254 Detail
chronic myeloid leukemia ABL1 p.Tyr272Phe (p.Y272F)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Tyr272Phe (p.Y272F)
( ENST00000318560.6, ENST00000372348.9 )
C Predictive Supports Resistance Somatic 15930265 Detail
chronic myeloid leukemia ABL1 p.Glu274Lys (p.E274K) ABL1 p.Glu274Lys (p.E274K) D Predictive Supports Resistance Somatic 3 19075254 Detail
chronic myeloid leukemia ABL1 p.Glu274Lys (p.E274K) ABL1 p.Glu274Lys (p.E274K) D Predictive Supports Resistance Somatic 3 15930265 Detail
chronic myeloid leukemia ABL1 p.Asp295Gly (p.D295G)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Asp295Gly (p.D295G)
( ENST00000318560.6, ENST00000372348.9 )
D Predictive Supports Resistance Somatic 2 19075254 Detail
chronic myeloid leukemia ABL1 p.Thr334Ile (p.T334I) ABL1 p.Thr334Ile (p.T334I) D Predictive Supports Resistance Somatic 4 19075254 Detail
chronic myeloid leukemia ABL1 p.Thr334Ile (p.T334I) ABL1 p.Thr334Ile (p.T334I) C Predictive Supports Resistance Somatic 15930265 Detail
chronic myeloid leukemia ABL1 p.Phe336Leu (p.F336L) ABL1 p.Phe336Leu (p.F336L) D Predictive Supports Resistance Somatic 2 19075254 Detail
chronic myeloid leukemia ABL1 p.Phe336Leu (p.F336L) ABL1 p.Phe336Leu (p.F336L) C Predictive Supports Resistance Somatic 15930265 Detail
chronic myeloid leukemia ABL1 p.Phe336Leu (p.F336L) ABL1 p.Phe336Leu (p.F336L) C Predictive Supports Resistance Somatic 15930265 Detail
chronic myeloid leukemia ABL1 p.Met370Thr (p.M370T)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Met370Thr (p.M370T)
( ENST00000318560.6, ENST00000372348.9 )
D Predictive Supports Sensitivity/Response Somatic 3 19075254 Detail
chronic myeloid leukemia ABL1 p.Met370Thr (p.M370T)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Met370Thr (p.M370T)
( ENST00000318560.6, ENST00000372348.9 )
C Predictive Supports Sensitivity/Response Somatic 15930265 Detail
chronic myeloid leukemia ABL1 p.His415Arg (p.H415R)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.His415Arg (p.H415R)
( ENST00000318560.6, ENST00000372348.9 )
D Predictive Supports Resistance Somatic 2 19075254 Detail
chronic myeloid leukemia ABL1 p.His415Arg (p.H415R)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.His415Arg (p.H415R)
( ENST00000318560.6, ENST00000372348.9 )
C Predictive Supports Resistance Somatic 15930265 Detail
melanoma KIT p.Asp821Tyr (p.D821Y)
( ENST00000412167.7, ENST00000689832.1, ENST00000288135.6, ENST00000687246.1, ENST00000686011.1, ENST00000687109.1, ENST00000687295.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Asp821Tyr (p.D821Y)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
C Predictive Supports Resistance Somatic 3 21642685 Detail
mucosal melanoma KIT p.Lys643Glu (p.K643E)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Lys643Glu (p.K643E)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
C Predictive Supports Sensitivity/Response Somatic 2 18510589 Detail
gastrointestinal stromal tumor KIT p.Asn823Lys (p.N823K)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687246.1, ENST00000687109.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Asn823Lys (p.N823K)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
C Predictive Supports Resistance Somatic 3 16954519 Detail
gastrointestinal stromal tumor KIT p.Tyr824Asp (p.Y824D)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Tyr824Asp (p.Y824D)
( ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000288135.6, ENST00000412167.7, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
C Predictive Supports Resistance Somatic 3 16954519 Detail
gastrointestinal stromal tumor KIT p.Cys810Gly (p.C810G)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Cys810Gly (p.C810G)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
C Predictive Supports Resistance Somatic 3 16954519 Detail
gastrointestinal stromal tumor KIT p.Asp821Ala (p.D821A)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Asp821Ala (p.D821A)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
C Predictive Supports Resistance Somatic 3 16954519 Detail
gastrointestinal stromal tumor KIT p.Asp821Gly (p.D821G)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Asp821Gly (p.D821G)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
C Predictive Supports Resistance Somatic 3 16954519 Detail
gastrointestinal stromal tumor KIT p.Asp817His (p.D817H)
( ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1, ENST00000288135.6, ENST00000412167.7, ENST00000686011.1 ) KIT p.Asp817His (p.D817H)
( ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1, ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1 )
C Predictive Supports Resistance Somatic 3 16954519 Detail
gastrointestinal stromal tumor KIT p.Thr671Ile (p.T671I)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Thr671Ile (p.T671I)
( ENST00000412167.7, ENST00000288135.6, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
C Predictive Supports Resistance Somatic 3 16954519 Detail
malignant anus melanoma KIT EXON 11 MUTATION KIT EXON 11 MUTATION C Predictive Supports Sensitivity/Response Somatic 3 18421059 Detail
gastrointestinal stromal tumor KIT p.Val560Asp (p.V560D)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Val560Asp (p.V560D)
( ENST00000690543.1, ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000692783.1 )
C Predictive Supports Sensitivity/Response Somatic 3 22114577 Detail
cancer KIT p.Val560Asp (p.V560D)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Val560Asp (p.V560D)
( ENST00000690543.1, ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000692783.1 )
D Predictive Supports Sensitivity/Response Somatic 2 16046538 Detail
lung non-small cell carcinoma KIT p.Leu577Pro (p.L577P)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Leu577Pro (p.L577P)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
D Predictive Supports Sensitivity/Response Somatic 3 17372901 Detail
melanoma KIT p.Leu577Pro (p.L577P)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Leu577Pro (p.L577P)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
D Predictive Supports Resistance Somatic 3 19671763 Detail
chronic myeloid leukemia ABL1 BCR-ABL A Predictive Supports Sensitivity/Response Somatic 5 20537386 Detail
acute lymphoblastic leukemia CSF1R MEF2D-CSF1R D Predictive Supports Sensitivity/Response Somatic 3 24186003 Detail
gastrointestinal stromal tumor KIT p.Trp558_Lys559del (p.W558_K559del)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1, ENST00000687109.1, ENST00000687246.1 ) KIT p.Trp558_Lys559del (p.W558_K559del)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
D Predictive Supports Sensitivity/Response Somatic 3 25239608 Detail
gastrointestinal stromal tumor KIT p.Val561Asp (p.V561D)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Val561Asp (p.V561D)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
D Predictive Supports Sensitivity/Response Somatic 3 25239608 Detail
cancer KIT p.Leu577Pro (p.L577P)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Leu577Pro (p.L577P)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
D Predictive Supports Sensitivity/Response Somatic 2 25317746 Detail
gastrointestinal stromal tumor KIT P551_E554delPMYE KIT P551_E554delPMYE D Predictive Does Not Support Sensitivity/Response Somatic 3 25239608 Detail
gastrointestinal stromal tumor KIT p.Val560Asp (p.V560D)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Val560Asp (p.V560D)
( ENST00000690543.1, ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000692783.1 )
D Predictive Supports Sensitivity/Response Somatic 2 25239608 Detail
gastrointestinal stromal tumor KIT p.Pro552_Lys559del (p.P552_K559del)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Pro552_Lys559del (p.P552_K559del)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
D Predictive Supports Sensitivity/Response Somatic 4 25239608 Detail
gastrointestinal stromal tumor KIT p.Lys559delinsAsnPro (p.K559delinsNP)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Lys559delinsAsnPro (p.K559delinsNP)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
D Predictive Supports Sensitivity/Response Somatic 3 25239608 Detail
gastrointestinal stromal tumor KIT p.Ala503_Tyr504insAlaTyr (p.A503_Y504insAY)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Ala503_Tyr504insAlaTyr (p.A503_Y504insAY)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
D Predictive Does Not Support Sensitivity/Response Somatic 3 25239608 Detail
gastrointestinal stromal tumor KIT p.Asp817Glu (p.D817E)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Asp817Glu (p.D817E)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
D Predictive Supports Resistance Somatic 4 25239608 Detail
cancer KIT p.Ser629Asn (p.S629N)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Ser629Asn (p.S629N)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
D Predictive Supports Sensitivity/Response Somatic 2 25317746 Detail
thymic carcinoma KIT p.Val561del (p.V561del)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Val561del (p.V561del)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
C Predictive Supports Sensitivity/Response Somatic 5 15201427 Detail
melanoma KIT EXON 11 MUTATION KIT EXON 11 MUTATION B Predictive Supports Sensitivity/Response Somatic 3 23775962 Detail
lung non-small cell carcinoma ABL1 p.Arg351Trp (p.R351W)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Arg351Trp (p.R351W)
( ENST00000318560.6, ENST00000372348.9 )
D Predictive Supports Sensitivity/Response Somatic 5 26758680 Detail
gastrointestinal stromal tumor PDGFRA p.Asp842Val (p.D842V), ENSG00000282278 p.Asp602Val (p.D602V)
( ENST00000257290.10 ) PDGFRA p.Asp842Val (p.D842V), ENSG00000282278 p.Asp602Val (p.D602V)
( ENST00000257290.10 )
D Predictive Supports Resistance Somatic 3 12949711 Detail
gastrointestinal stromal tumor PDGFRA p.Val561Ala (p.V561A), ENSG00000282278 c.1018-56T>C
( ENST00000257290.10 ) PDGFRA p.Val561Ala (p.V561A), ENSG00000282278 c.1018-56T>C
( ENST00000257290.10 )
D Predictive Supports Sensitivity/Response Somatic 3 12949711 Detail
gastrointestinal stromal tumor KIT EXON 11 MUTATION KIT EXON 11 MUTATION B Predictive Supports Sensitivity/Response Somatic 4 14645423 Detail
childhood B-cell acute lymphoblastic leukemia PDGFRB EBF1-PDGFRB C Predictive Supports Sensitivity/Response Somatic 3 24186319 Detail
chronic myeloid leukemia ABL1 p.Gly269Glu (p.G269E)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Gly269Glu (p.G269E)
( ENST00000318560.6, ENST00000372348.9 )
C Predictive Supports Resistance Somatic 3 22371878 Detail
myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1 PDGFRA FIP1L1-PDGFRA T674I C Predictive Supports Resistance Somatic 3 21818111 Detail
childhood B-cell acute lymphoblastic leukemia PDGFRB EBF1-PDGFRB C Predictive Supports Sensitivity/Response Somatic 2 26872634 Detail
Pediatric B-lymphoblastic Leukemia PDGFRB EBF1-PDGFRB C Predictive Supports Sensitivity/Response Somatic 2 25207766 Detail
Pediatric B-cell Acute Lymphoblastic Leukemia ABL1 ABL1-RCSD ABL1 ABL1-RCSD C Predictive Supports Sensitivity/Response Somatic 3 25207766 Detail
gastrointestinal stromal tumor PDGFRA p.Asp842Val (p.D842V), ENSG00000282278 p.Asp602Val (p.D602V)
( ENST00000257290.10 ) PDGFRA p.Asp842Val (p.D842V), ENSG00000282278 p.Asp602Val (p.D602V)
( ENST00000257290.10 )
B Predictive Supports Resistance Somatic 4 26130666 Detail
gastrointestinal stromal tumor KIT V560_L576DEL KIT V560_L576DEL D Predictive Does Not Support Sensitivity/Response Somatic 4 25239608 Detail
gastrointestinal stromal tumor KIT p.Val561Gly (p.V561G)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Val561Gly (p.V561G)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
D Predictive Supports Sensitivity/Response Somatic 3 25239608 Detail
gastrointestinal stromal tumor KIT p.Asn823Lys (p.N823K)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687246.1, ENST00000687109.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Asn823Lys (p.N823K)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
D Predictive Supports Resistance Somatic 4 25239608 Detail
gastrointestinal stromal tumor KIT p.Ala830Pro (p.A830P)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Ala830Pro (p.A830P)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
D Predictive Supports Resistance Somatic 4 25239608 Detail
gastrointestinal stromal tumor KIT p.Thr671Ile (p.T671I)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Thr671Ile (p.T671I)
( ENST00000412167.7, ENST00000288135.6, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
D Predictive Supports Resistance Somatic 5 25239608 Detail
melanoma KIT p.Ser629Asn (p.S629N)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Ser629Asn (p.S629N)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
C Predictive Does Not Support Sensitivity/Response Somatic 3 25317746 Detail
cancer KIT p.Asp817Val (p.D817V)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Asp817Val (p.D817V)
( ENST00000686011.1, ENST00000687109.1, ENST00000288135.6, ENST00000412167.7, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
C Predictive Supports Resistance Somatic 2 25317746 Detail
Pediatric B-cell Acute Lymphoblastic Leukemia ABL1 SNX2-ABL1 Fusion D Predictive Supports Resistance Somatic 3 24367893 Detail
acute lymphoblastic leukemia ABL1 p.Thr334Ile (p.T334I) ABL1 p.Thr334Ile (p.T334I) D Predictive Supports Resistance Somatic 3 25686603 Detail
chronic myeloid leukemia ABL1 p.Thr334Ile (p.T334I) ABL1 p.Thr334Ile (p.T334I) D Predictive Supports Resistance Somatic 3 25686603 Detail
Pediatric B-lymphoblastic Leukemia ABL1 ABL1-RCSD1 C Predictive Supports Sensitivity/Response Somatic 3 27125982 Detail
chronic myeloid leukemia ABL1 BCR-ABL F311V ABL1 BCR-ABL F311V C Predictive Supports Resistance Somatic 1 16775234 Detail
chronic myeloid leukemia ABL1 BCR-ABL F311V ABL1 BCR-ABL F311V C Predictive Supports Resistance Somatic 1 16775234 Detail
chronic myeloid leukemia ABL1 p.Met263Val (p.M263V)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Met263Val (p.M263V)
( ENST00000318560.6, ENST00000372348.9 )
C Predictive Supports Resistance Somatic 1 16775234 Detail
B-cell acute lymphoblastic leukemia PDGFRA BCR-PDGFRA C Predictive Supports Sensitivity/Response Somatic 3 12944919 Detail
chronic myeloid leukemia ABL1 BCR-ABL F311V ABL1 BCR-ABL F311V C Predictive Supports Resistance Somatic 4 12623848 Detail
gastrointestinal stromal tumor KIT MUTATION KIT MUTATION D Predictive Supports Sensitivity/Response Somatic 2 23231951 Detail
Annotation
Description Associated Genes Associated Variants Sensitivity Supported Source Links
Case Report of a 42-year old patient with low-grad... KIT KIT EXPRESSION KIT EXPRESSION Sensitivity true CIViC Evidence detail
Case Report of a 41-year old patient with high-gra... KIT KIT EXPRESSION KIT EXPRESSION Sensitivity true CIViC Evidence detail
In a phase III clinical trial comparing different ... KIT KIT EXON 9 MUTATION KIT EXON 9 MUTATION Sensitivity true CIViC Evidence detail
In a phase II clinical trial of 43 melanoma patien... KIT KIT MUTATION KIT MUTATION Sensitivity true CIViC Evidence detail
DNA sequencing was performed in five Ph+ CML sampl... BCL2L11 BCL2L11 DELETION POLYMORPHISM BCL2L11 DELETION POLYMORPHISM Resitance or Non-Reponse true CIViC Evidence detail
15/127 patients with KIT-WT metastatic gastrointes... PDGFRA PDGFRA p.Ile843del (p.I843del), ENSG00000282278 p.Ile603del (p.I603del)
( ENST00000257290.10 ) PDGFRA p.Ile843del (p.I843del), ENSG00000282278 p.Ile603del (p.I603del)
( ENST00000257290.10 )
Sensitivity true CIViC Evidence detail
A 10-year-old boy with B-cell acute lymphoblastic ... PDGFRB PDGFRB EBF1-PDGFRB Sensitivity true CIViC Evidence detail
In 5 patients with KIT M541L mutation-positive chr... KIT KIT p.Met542Leu (p.M542L)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Met542Leu (p.M542L)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Sensitivity true CIViC Evidence detail
A cohort of seven male patients with myeloprolifer... PDGFRA PDGFRA FIP1L1-PDGFRA Sensitivity true CIViC Evidence detail
Of eleven patients prospectively accrued with hype... PDGFRA PDGFRA FIP1L1-PDGFRA Sensitivity true CIViC Evidence detail
A patient treated with imatinib for a FIP1L1-PDGFR... PDGFRA PDGFRA FIP1L1-PDGFRA T674I Resitance or Non-Reponse true CIViC Evidence detail
Phase 2 trial in metastatic mucosal, acral or chro... KIT KIT AMPLIFICATION
( ENST00000288135.6 ) KIT AMPLIFICATION
( ENST00000288135.6 )
Resitance or Non-Reponse true CIViC Evidence detail
Twelve patients with BCR-ABL-negative chronic myel... PDGFRB PDGFRB PDGFRB FUSIONS PDGFRB PDGFRB FUSIONS Sensitivity true CIViC Evidence detail
GIST cancer with D842V mutation is resistant to im... PDGFRA PDGFRA p.Asp842Val (p.D842V), ENSG00000282278 p.Asp602Val (p.D602V)
( ENST00000257290.10 ) PDGFRA p.Asp842Val (p.D842V), ENSG00000282278 p.Asp602Val (p.D602V)
( ENST00000257290.10 )
Resitance or Non-Reponse true CIViC Evidence detail
While cancer with PDGFRA V561D mutation is known t... PDGFRA PDGFRA p.Asp842Val (p.D842V), ENSG00000282278 p.Asp602Val (p.D602V)
( ENST00000257290.10 ) PDGFRA p.Asp842Val (p.D842V), ENSG00000282278 p.Asp602Val (p.D602V)
( ENST00000257290.10 )
Resitance or Non-Reponse true CIViC Evidence detail
A patient with monoblastic myeloid sarcoma harbour... PDGFRA PDGFRA FIP1L1-PDGFRA Sensitivity true CIViC Evidence detail
A patient harbouring a novel TNKS2–PDGFRA fusion i... PDGFRA PDGFRA TNKS2-PDGFRA Sensitivity true CIViC Evidence detail
Five PDGFRA Mutations (P577S, V658A, R841K, H845Y,... PDGFRA PDGFRA p.Pro577Ser (p.P577S), ENSG00000282278 c.1018-9C>T
( ENST00000257290.10 ) PDGFRA p.Pro577Ser (p.P577S), ENSG00000282278 c.1018-9C>T
( ENST00000257290.10 )
Sensitivity true CIViC Evidence detail
Five PDGFRA Mutations (P577S, V658A, R841K, H845Y,... PDGFRA PDGFRA p.Arg841Lys (p.R841K), ENSG00000282278 p.Arg601Lys (p.R601K)
( ENST00000257290.10 ) PDGFRA p.Arg841Lys (p.R841K), ENSG00000282278 p.Arg601Lys (p.R601K)
( ENST00000257290.10 )
Sensitivity true CIViC Evidence detail
Five PDGFRA Mutations (P577S, V658A, R841K, H845Y,... PDGFRA PDGFRA p.His845Tyr (p.H845Y), ENSG00000282278 p.His605Tyr (p.H605Y)
( ENST00000257290.10 ) PDGFRA p.His845Tyr (p.H845Y), ENSG00000282278 p.His605Tyr (p.H605Y)
( ENST00000257290.10 )
Sensitivity true CIViC Evidence detail
Five PDGFRA Mutations (P577S, V658A, R841K, H845Y,... PDGFRA PDGFRA p.Gly853Asp (p.G853D), ENSG00000282278 p.Gly613Asp (p.G613D)
( ENST00000257290.10 ) PDGFRA p.Gly853Asp (p.G853D), ENSG00000282278 p.Gly613Asp (p.G613D)
( ENST00000257290.10 )
Sensitivity true CIViC Evidence detail
A panel of 18 mutations representing 85% of known ... ABL1 ABL1 p.Phe378Val (p.F378V)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Phe378Val (p.F378V)
( ENST00000318560.6, ENST00000372348.9 )
Resitance or Non-Reponse true CIViC Evidence detail
In two cell-based studies, a panel of either 18 or... ABL1 ABL1 p.Phe378Val (p.F378V)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Phe378Val (p.F378V)
( ENST00000318560.6, ENST00000372348.9 )
Resitance or Non-Reponse true CIViC Evidence detail
BCR-ABL fusions have been found to contribute to i... ABL1 ABL1 BCR-ABL Resitance or Non-Reponse true CIViC Evidence detail
COS7 cell lines transfected with BCR-ABL construct... ABL1 ABL1 p.Glu274Lys (p.E274K) ABL1 p.Glu274Lys (p.E274K) Resitance or Non-Reponse true CIViC Evidence detail
In chronic myeloid leukemia patients with the ABL ... ABL1 ABL1 p.Thr334Ile (p.T334I) ABL1 p.Thr334Ile (p.T334I) Resitance or Non-Reponse true CIViC Evidence detail
COS7 cell lines transfected with BCR-ABL construct... ABL1 ABL1 p.Thr334Ile (p.T334I) ABL1 p.Thr334Ile (p.T334I) Resitance or Non-Reponse true CIViC Evidence detail
This patient was part of a larger cohort of 397 pa... KIT KIT UNKNOWN KIT W557_V559insC Sensitivity true CIViC Evidence detail
This patient was part of a larger cohort of 397 pa... KIT KIT UNKNOWN KIT W557_V559insC Sensitivity false CIViC Evidence detail
In an in vitro study of imatinib sensitivity, KIT ... KIT KIT p.Asn823His (p.N823H)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Asn823His (p.N823H)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Resitance or Non-Reponse false CIViC Evidence detail
In an in vitro study of imatinib sensitivity, KIT ... KIT KIT p.Asn823Lys (p.N823K)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687246.1, ENST00000687109.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Asn823Lys (p.N823K)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Sensitivity false CIViC Evidence detail
In an in vitro study of imatinib sensitivity, KIT ... KIT KIT p.Asp817Val (p.D817V)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Asp817Val (p.D817V)
( ENST00000686011.1, ENST00000687109.1, ENST00000288135.6, ENST00000412167.7, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Resitance or Non-Reponse true CIViC Evidence detail
In an in vitro study of imatinib sensitivity, PDGF... PDGFRA PDGFRA p.Val561Asp (p.V561D), ENSG00000282278 c.1018-56T>A
( ENST00000257290.10 ) PDGFRA p.Val561Asp (p.V561D), ENSG00000282278 c.1018-56T>A
( ENST00000257290.10 )
Resitance or Non-Reponse false CIViC Evidence detail
In an in vitro study of imatinib sensitivity, PDGF... PDGFRA PDGFRA D842_H845DELDIMH PDGFRA D842_H845DELDIMH Resitance or Non-Reponse false CIViC Evidence detail
In an in vitro study of imatinib sensitivity, PDGF... PDGFRA PDGFRA p.Asp842Val (p.D842V), ENSG00000282278 p.Asp602Val (p.D602V)
( ENST00000257290.10 ) PDGFRA p.Asp842Val (p.D842V), ENSG00000282278 p.Asp602Val (p.D602V)
( ENST00000257290.10 )
Resitance or Non-Reponse true CIViC Evidence detail
This patient was from a larger cohort of 397 patie... KIT KIT UNKNOWN KIT W557_V559insC Sensitivity true CIViC Evidence detail
This prospective study of 127 patients with metast... KIT KIT EXON 9 MUTATION KIT EXON 9 MUTATION Sensitivity true CIViC Evidence detail
In an in vitro study of imatinib sensitivity, KIT ... KIT KIT p.Val561Gly (p.V561G)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Val561Gly (p.V561G)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Resitance or Non-Reponse false CIViC Evidence detail
This prospective study of 397 patients with incura... KIT KIT EXON 11 MUTATION KIT EXON 11 MUTATION Sensitivity true CIViC Evidence detail
In an in vitro study of imatinib sensitivity, KIT ... KIT KIT p.Lys643Glu (p.K643E)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Lys643Glu (p.K643E)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Resitance or Non-Reponse false CIViC Evidence detail
This case study examines one patient from a larger... PDGFRA PDGFRA p.Val561Asp (p.V561D), ENSG00000282278 c.1018-56T>A
( ENST00000257290.10 ) PDGFRA p.Val561Asp (p.V561D), ENSG00000282278 c.1018-56T>A
( ENST00000257290.10 )
Sensitivity true CIViC Evidence detail
This prospective study of 127 patients with metast... KIT KIT MUTATION KIT MUTATION Sensitivity true CIViC Evidence detail
This prospective study of 397 patients with incura... KIT KIT EXON 9 MUTATION KIT EXON 9 MUTATION N/A true CIViC Evidence detail
This prospective study of 127 patients with metast... PDGFRA PDGFRA p.Asp842Val (p.D842V), ENSG00000282278 p.Asp602Val (p.D602V)
( ENST00000257290.10 ) PDGFRA p.Asp842Val (p.D842V), ENSG00000282278 p.Asp602Val (p.D602V)
( ENST00000257290.10 )
Resitance or Non-Reponse true CIViC Evidence detail
In a prospective phase III study (SWOG S0033/CALGB... KIT KIT EXPRESSION KIT EXPRESSION Sensitivity true CIViC Evidence detail
In an in vitro study of imatinib sensitivity, KIT ... KIT KIT p.Trp558_Lys559del (p.W558_K559del)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1, ENST00000687109.1, ENST00000687246.1 ) KIT p.Trp558_Lys559del (p.W558_K559del)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Resitance or Non-Reponse false CIViC Evidence detail
In an in vitro study of imatinib sensitivity, KIT ... KIT KIT p.Ala503_Tyr504dup (p.A503_Y504dup)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Ala503_Tyr504dup (p.A503_Y504dup)
( ENST00000690543.1, ENST00000692783.1, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000288135.6 )
Resitance or Non-Reponse false CIViC Evidence detail
These four patients were part of a larger cohort o... PDGFRA PDGFRA MUTATION PDGFRA MUTATION Sensitivity false CIViC Evidence detail
This prospective study of 127 patients with metast... KIT KIT p.Asp580del (p.D580del)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Asp580del (p.D580del)
( ENST00000412167.7, ENST00000288135.6, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Sensitivity true CIViC Evidence detail
KIT V654A results in imatinib resistance in GIST p... KIT KIT p.Val655Ala (p.V655A)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Val655Ala (p.V655A)
( ENST00000689832.1, ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Resitance or Non-Reponse true CIViC Evidence detail
Treatment of Philadelphia chromosome positive leuk... ABL1 ABL1 BCR-ABL Sensitivity true CIViC Evidence detail
The clinical use of imatinib in patients with BCR-... ABL1 ABL1 BCR-ABL Sensitivity true CIViC Evidence detail
In two cell-based studies, a panel of either 18 or... ABL1 ABL1 p.Met263Val (p.M263V)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Met263Val (p.M263V)
( ENST00000318560.6, ENST00000372348.9 )
Sensitivity true CIViC Evidence detail
A panel of 18 mutations representing 85% of known ... ABL1 ABL1 p.Leu267Val (p.L267V)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Leu267Val (p.L267V)
( ENST00000318560.6, ENST00000372348.9 )
Resitance or Non-Reponse true CIViC Evidence detail
A panel of 18 mutations representing 85% of known ... ABL1 ABL1 p.Gly269Glu (p.G269E)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Gly269Glu (p.G269E)
( ENST00000318560.6, ENST00000372348.9 )
Resitance or Non-Reponse true CIViC Evidence detail
In two cell-based studies, a panel of either 18 or... ABL1 ABL1 p.Gly269Glu (p.G269E)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Gly269Glu (p.G269E)
( ENST00000318560.6, ENST00000372348.9 )
Resitance or Non-Reponse true CIViC Evidence detail
A panel of 18 mutations representing 85% of known ... ABL1 ABL1 p.Gln271His (p.Q271H)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Gln271His (p.Q271H)
( ENST00000318560.6, ENST00000372348.9 )
Sensitivity true CIViC Evidence detail
A panel of 18 mutations representing 85% of known ... ABL1 ABL1 p.Tyr272Phe (p.Y272F)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Tyr272Phe (p.Y272F)
( ENST00000318560.6, ENST00000372348.9 )
Resitance or Non-Reponse true CIViC Evidence detail
In two cell-based studies, a panel of either 18 or... ABL1 ABL1 p.Tyr272Phe (p.Y272F)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Tyr272Phe (p.Y272F)
( ENST00000318560.6, ENST00000372348.9 )
Resitance or Non-Reponse true CIViC Evidence detail
A panel of 18 mutations representing 85% of known ... ABL1 ABL1 p.Glu274Lys (p.E274K) ABL1 p.Glu274Lys (p.E274K) Resitance or Non-Reponse true CIViC Evidence detail
A panel of 16 mutations seen in imatinib CML paten... ABL1 ABL1 p.Glu274Lys (p.E274K) ABL1 p.Glu274Lys (p.E274K) Resitance or Non-Reponse true CIViC Evidence detail
A panel of 18 mutations representing 85% of known ... ABL1 ABL1 p.Asp295Gly (p.D295G)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Asp295Gly (p.D295G)
( ENST00000318560.6, ENST00000372348.9 )
Resitance or Non-Reponse true CIViC Evidence detail
A panel of 18 mutations representing 85% of known ... ABL1 ABL1 p.Thr334Ile (p.T334I) ABL1 p.Thr334Ile (p.T334I) Resitance or Non-Reponse true CIViC Evidence detail
In two cell-based studies, a panel of either 18 or... ABL1 ABL1 p.Thr334Ile (p.T334I) ABL1 p.Thr334Ile (p.T334I) Resitance or Non-Reponse true CIViC Evidence detail
A panel of 18 mutations representing 85% of known ... ABL1 ABL1 p.Phe336Leu (p.F336L) ABL1 p.Phe336Leu (p.F336L) Resitance or Non-Reponse true CIViC Evidence detail
In two cell-based studies, a panel of either 18 or... ABL1 ABL1 p.Phe336Leu (p.F336L) ABL1 p.Phe336Leu (p.F336L) Resitance or Non-Reponse true CIViC Evidence detail
In two cell-based studies, a panel of either 18 or... ABL1 ABL1 p.Phe336Leu (p.F336L) ABL1 p.Phe336Leu (p.F336L) Resitance or Non-Reponse true CIViC Evidence detail
A panel of 18 mutations representing 85% of known ... ABL1 ABL1 p.Met370Thr (p.M370T)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Met370Thr (p.M370T)
( ENST00000318560.6, ENST00000372348.9 )
Sensitivity true CIViC Evidence detail
In two cell-based studies, a panel of either 18 or... ABL1 ABL1 p.Met370Thr (p.M370T)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Met370Thr (p.M370T)
( ENST00000318560.6, ENST00000372348.9 )
Sensitivity true CIViC Evidence detail
A panel of 18 mutations representing 85% of known ... ABL1 ABL1 p.His415Arg (p.H415R)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.His415Arg (p.H415R)
( ENST00000318560.6, ENST00000372348.9 )
Resitance or Non-Reponse true CIViC Evidence detail
In two cell-based studies, a panel of either 18 or... ABL1 ABL1 p.His415Arg (p.H415R)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.His415Arg (p.H415R)
( ENST00000318560.6, ENST00000372348.9 )
Resitance or Non-Reponse true CIViC Evidence detail
FFPE tumor specimens from 295 melanoma patients we... KIT KIT p.Asp821Tyr (p.D821Y)
( ENST00000412167.7, ENST00000689832.1, ENST00000288135.6, ENST00000687246.1, ENST00000686011.1, ENST00000687109.1, ENST00000687295.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Asp821Tyr (p.D821Y)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Resitance or Non-Reponse true CIViC Evidence detail
A 69 y.o. woman presented with metastatic mucosal ... KIT KIT p.Lys643Glu (p.K643E)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Lys643Glu (p.K643E)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Sensitivity true CIViC Evidence detail
147 patients with advanced, unresectable GISTs wer... KIT KIT p.Asn823Lys (p.N823K)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687246.1, ENST00000687109.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Asn823Lys (p.N823K)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Resitance or Non-Reponse true CIViC Evidence detail
147 patients with advanced, unresectable GISTs wer... KIT KIT p.Tyr824Asp (p.Y824D)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Tyr824Asp (p.Y824D)
( ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000288135.6, ENST00000412167.7, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Resitance or Non-Reponse true CIViC Evidence detail
147 patients with advanced, unresectable GISTs wer... KIT KIT p.Cys810Gly (p.C810G)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Cys810Gly (p.C810G)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Resitance or Non-Reponse true CIViC Evidence detail
147 patients with advanced, unresectable GISTs wer... KIT KIT p.Asp821Ala (p.D821A)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Asp821Ala (p.D821A)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Resitance or Non-Reponse true CIViC Evidence detail
147 patients with advanced, unresectable GISTs wer... KIT KIT p.Asp821Gly (p.D821G)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Asp821Gly (p.D821G)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Resitance or Non-Reponse true CIViC Evidence detail
147 patients with advanced, unresectable GISTs wer... KIT KIT p.Asp817His (p.D817H)
( ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1, ENST00000288135.6, ENST00000412167.7, ENST00000686011.1 ) KIT p.Asp817His (p.D817H)
( ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1, ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1 )
Resitance or Non-Reponse true CIViC Evidence detail
147 patients with advanced, unresectable GISTs wer... KIT KIT p.Thr671Ile (p.T671I)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Thr671Ile (p.T671I)
( ENST00000412167.7, ENST00000288135.6, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Resitance or Non-Reponse true CIViC Evidence detail
In a case study, a patient with anal melanoma harb... KIT KIT EXON 11 MUTATION KIT EXON 11 MUTATION Sensitivity true CIViC Evidence detail
A patient with an uncontrolled relapse of c-kit-po... KIT KIT p.Val560Asp (p.V560D)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Val560Asp (p.V560D)
( ENST00000690543.1, ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000692783.1 )
Sensitivity true CIViC Evidence detail
KIT(V559D) were expressed in HEK-293 cells (in vit... KIT KIT p.Val560Asp (p.V560D)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Val560Asp (p.V560D)
( ENST00000690543.1, ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000692783.1 )
Sensitivity true CIViC Evidence detail
Ba/F3 cells harboring the KIT L576P mutation are s... KIT KIT p.Leu577Pro (p.L577P)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Leu577Pro (p.L577P)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Sensitivity true CIViC Evidence detail
The melanoma cell line WM3211, which harbors the L... KIT KIT p.Leu577Pro (p.L577P)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Leu577Pro (p.L577P)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Resitance or Non-Reponse true CIViC Evidence detail
BCR-ABL inhibitors such as imatinib have lead to s... ABL1 ABL1 BCR-ABL Sensitivity true CIViC Evidence detail
Cell lines with MEF2D-CSF1R fusion show sensitivit... CSF1R CSF1R MEF2D-CSF1R Sensitivity true CIViC Evidence detail
In an in vitro study, an IL3 independent Ba/F3 cel... KIT KIT p.Trp558_Lys559del (p.W558_K559del)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1, ENST00000687109.1, ENST00000687246.1 ) KIT p.Trp558_Lys559del (p.W558_K559del)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Sensitivity true CIViC Evidence detail
In an in vitro study, an IL3 independent Ba/F3 cel... KIT KIT p.Val561Asp (p.V561D)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Val561Asp (p.V561D)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Sensitivity true CIViC Evidence detail
In an in vitro study, COS-7 cells expressing KIT L... KIT KIT p.Leu577Pro (p.L577P)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Leu577Pro (p.L577P)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Sensitivity true CIViC Evidence detail
In an in vitro study, an IL3 independent Ba/F3 cel... KIT KIT P551_E554delPMYE KIT P551_E554delPMYE Sensitivity false CIViC Evidence detail
In an in vitro kinase study, a KIT V559D primary a... KIT KIT p.Val560Asp (p.V560D)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Val560Asp (p.V560D)
( ENST00000690543.1, ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000692783.1 )
Sensitivity true CIViC Evidence detail
In an in vitro study, an IL3 independent Ba/F3 cel... KIT KIT p.Pro552_Lys559del (p.P552_K559del)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Pro552_Lys559del (p.P552_K559del)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Sensitivity true CIViC Evidence detail
In an in vitro study, an IL3 independent Ba/F3 cel... KIT KIT p.Lys559delinsAsnPro (p.K559delinsNP)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Lys559delinsAsnPro (p.K559delinsNP)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Sensitivity true CIViC Evidence detail
In an in vitro study, an IL3 independent Ba/F3 cel... KIT KIT p.Ala503_Tyr504insAlaTyr (p.A503_Y504insAY)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Ala503_Tyr504insAlaTyr (p.A503_Y504insAY)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Sensitivity false CIViC Evidence detail
Several preclinical studies were done in order to ... KIT KIT p.Asp817Glu (p.D817E)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Asp817Glu (p.D817E)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Resitance or Non-Reponse true CIViC Evidence detail
In an in vitro study, COS-7 cells expressing KIT S... KIT KIT p.Ser629Asn (p.S629N)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Ser629Asn (p.S629N)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Sensitivity true CIViC Evidence detail
In a patient with thymic carcinoma, the tumor expr... KIT KIT p.Val561del (p.V561del)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Val561del (p.V561del)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Sensitivity true CIViC Evidence detail
Melanoma patients with KIT mutation but not KIT am... KIT KIT EXON 11 MUTATION KIT EXON 11 MUTATION Sensitivity true CIViC Evidence detail
In this in vitro study, the H1915 non-small cell l... ABL1 ABL1 p.Arg351Trp (p.R351W)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Arg351Trp (p.R351W)
( ENST00000318560.6, ENST00000372348.9 )
Sensitivity true CIViC Evidence detail
When 293T cells stably transduced with PDGFRA A842... PDGFRA PDGFRA p.Asp842Val (p.D842V), ENSG00000282278 p.Asp602Val (p.D602V)
( ENST00000257290.10 ) PDGFRA p.Asp842Val (p.D842V), ENSG00000282278 p.Asp602Val (p.D602V)
( ENST00000257290.10 )
Resitance or Non-Reponse true CIViC Evidence detail
293T cells stably transduced with PDGFRA V561A sho... PDGFRA PDGFRA p.Val561Ala (p.V561A), ENSG00000282278 c.1018-56T>C
( ENST00000257290.10 ) PDGFRA p.Val561Ala (p.V561A), ENSG00000282278 c.1018-56T>C
( ENST00000257290.10 )
Sensitivity true CIViC Evidence detail
This prospective study of 127 pretreatment patient... KIT KIT EXON 11 MUTATION KIT EXON 11 MUTATION Sensitivity true CIViC Evidence detail
A 16-year-old boy with B-cell acute lymphoblastic ... PDGFRB PDGFRB EBF1-PDGFRB Sensitivity true CIViC Evidence detail
In a study of 39 chronic phase CML patients with B... ABL1 ABL1 p.Gly269Glu (p.G269E)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Gly269Glu (p.G269E)
( ENST00000318560.6, ENST00000372348.9 )
Resitance or Non-Reponse true CIViC Evidence detail
One patient with FIP1L1/PDGFRA-positive CEL was id... PDGFRA PDGFRA FIP1L1-PDGFRA T674I Resitance or Non-Reponse true CIViC Evidence detail
Two patients with EBF1-PDGFRB positive pediatric B... PDGFRB PDGFRB EBF1-PDGFRB Sensitivity true CIViC Evidence detail
The EBF1-PDGFRB fusion was detected in leukemia ce... PDGFRB PDGFRB EBF1-PDGFRB Sensitivity true CIViC Evidence detail
The ABL1-RCSD1 fusion was identified in a 6 yo boy... ABL1 ABL1 ABL1-RCSD ABL1 ABL1-RCSD Sensitivity true CIViC Evidence detail
823 patients with GIST under therapy with imatinib... PDGFRA PDGFRA p.Asp842Val (p.D842V), ENSG00000282278 p.Asp602Val (p.D602V)
( ENST00000257290.10 ) PDGFRA p.Asp842Val (p.D842V), ENSG00000282278 p.Asp602Val (p.D602V)
( ENST00000257290.10 )
Resitance or Non-Reponse true CIViC Evidence detail
In the patient-derived cell line GIST430 harboring... KIT KIT V560_L576DEL KIT V560_L576DEL Sensitivity false CIViC Evidence detail
In an in vitro kinase study, a KIT V560G primary a... KIT KIT p.Val561Gly (p.V561G)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Val561Gly (p.V561G)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Sensitivity true CIViC Evidence detail
Several preclinical studies tested the effects of ... KIT KIT p.Asn823Lys (p.N823K)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687246.1, ENST00000687109.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Asn823Lys (p.N823K)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Resitance or Non-Reponse true CIViC Evidence detail
Several preclinical studies tested the effects of ... KIT KIT p.Ala830Pro (p.A830P)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Ala830Pro (p.A830P)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Resitance or Non-Reponse true CIViC Evidence detail
A preclinical study tested the effects of a tyrosi... KIT KIT p.Thr671Ile (p.T671I)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Thr671Ile (p.T671I)
( ENST00000412167.7, ENST00000288135.6, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Resitance or Non-Reponse true CIViC Evidence detail
A melanoma patient harboring the KIT S628N activat... KIT KIT p.Ser629Asn (p.S629N)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Ser629Asn (p.S629N)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Sensitivity false CIViC Evidence detail
In an in vitro study, COS-7 cells expressing KIT D... KIT KIT p.Asp817Val (p.D817V)
( ENST00000288135.6, ENST00000412167.7, ENST00000686011.1, ENST00000687109.1, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 ) KIT p.Asp817Val (p.D817V)
( ENST00000686011.1, ENST00000687109.1, ENST00000288135.6, ENST00000412167.7, ENST00000687246.1, ENST00000687295.1, ENST00000689832.1, ENST00000689994.1, ENST00000690543.1, ENST00000692783.1 )
Resitance or Non-Reponse true CIViC Evidence detail
SNX2-ABL1 protein (SNX2 exon 3 to ABL1 exon 4) was... ABL1 ABL1 SNX2-ABL1 Fusion Resitance or Non-Reponse true CIViC Evidence detail
Bone marrow mononuclear cells (BM MNCs) isolated f... ABL1 ABL1 p.Thr334Ile (p.T334I) ABL1 p.Thr334Ile (p.T334I) Resitance or Non-Reponse true CIViC Evidence detail
Bone marrow mononuclear cells (BM MNCs) were isola... ABL1 ABL1 p.Thr334Ile (p.T334I) ABL1 p.Thr334Ile (p.T334I) Resitance or Non-Reponse true CIViC Evidence detail
This case report describes a patient with relapsed... ABL1 ABL1 ABL1-RCSD1 Sensitivity true CIViC Evidence detail
One chronic myeloid leukemia patient in chronic ph... ABL1 ABL1 BCR-ABL F311V ABL1 BCR-ABL F311V Resitance or Non-Reponse true CIViC Evidence detail
One chronic myeloid leukemia patient in chronic ph... ABL1 ABL1 BCR-ABL F311V ABL1 BCR-ABL F311V Resitance or Non-Reponse true CIViC Evidence detail
One chronic myeloid leukemia patient in chronic ph... ABL1 ABL1 p.Met263Val (p.M263V)
( ENST00000318560.6, ENST00000372348.9 ) ABL1 p.Met263Val (p.M263V)
( ENST00000318560.6, ENST00000372348.9 )
Resitance or Non-Reponse true CIViC Evidence detail
A 47-year-old man was diagnosed with pre-B-cell ac... PDGFRA PDGFRA BCR-PDGFRA Sensitivity true CIViC Evidence detail
In this study, patients on imatinib monotherapy we... ABL1 ABL1 BCR-ABL F311V ABL1 BCR-ABL F311V Resitance or Non-Reponse true CIViC Evidence detail
Human GISTs with different KIT mutations were graf... KIT KIT MUTATION KIT MUTATION Sensitivity true CIViC Evidence detail
Imatinib: small molecule inhibitor of tyrosine kin... PDGFRA PDGFRA EXPRESSION Resitance or Non-Reponse true MMMP detail
Imatinib: small molecule inhibitor of tyrosine kin... PDGFRB PDGFRB EXPRESSION Resitance or Non-Reponse true MMMP detail
Imatinib: small molecule inhibitor of tyrosine kin... PDGFRB PDGFRB EXPRESSION Resitance or Non-Reponse true MMMP detail
KIT inhibitor imatinib works against KIT mutant-tr... KIT KIT L576P Sensitivity true MMMP detail
KIT inhibitor imatinib works against KIT mutant-tr... KIT KIT K642E Sensitivity true MMMP detail
KIT inhibitor imatinib works against KIT mutant-tr... KRAS KRAS G12V Resitance or Non-Reponse true MMMP detail
Mucosal melanoma; no active control trial (histori... KIT KIT K642E Sensitivity true MMMP detail
Uveal melanoma; no KIT mutations found. The result... KIT KIT EXPRESSION Sensitivity true MMMP detail
Acral lentiginous melanoma. While imatinib did not... KIT KIT D820Y Resitance or Non-Reponse true MMMP detail
Acral and mucosal melanoma; no active control tria... KIT KIT AMP Sensitivity true MMMP detail
Acral and mucosal melanoma; no active control tria... KIT KIT UNKNOWN Sensitivity true MMMP detail
Mucosal melanoma; no active control trial (histori... KIT KIT AMP Sensitivity true MMMP detail
Imatinib mesylate had no effects on three cutaneou... KIT KIT WILD_TYPE Resitance or Non-Reponse true MMMP detail
Mucosal melanoma.Mucosal melanoma cells exhibited ... KIT KIT WILD_TYPE Resitance or Non-Reponse true MMMP detail
No correlation of effect was noted with c-Kit, pla... KIT KIT EXPRESSION Resitance or Non-Reponse true MMMP detail
Uveal melanoma; no KIT mutations found KIT KIT WILD_TYPE Sensitivity true MMMP detail
Imatinib: small molecule inhibitor of tyrosine kin... KIT KIT EXPRESSION Resitance or Non-Reponse true MMMP detail
Imatinib: small molecule inhibitor of tyrosine kin... KIT KIT EXPRESSION Resitance or Non-Reponse true MMMP detail
Uveal melanoma (molecularly unselected patients) KIT KIT UNKNOWN Resitance or Non-Reponse true MMMP detail
The melanoma cell lines showed a heterogenous expr... KIT KIT WILD_TYPE Resitance or Non-Reponse true MMMP detail
In vitro testing showed that the cell viability of... KIT KIT L576P Resitance or Non-Reponse true MMMP detail
Metastatic melanoma (molecularly unselected patien... KIT KIT UNKNOWN Resitance or Non-Reponse true MMMP detail
Uveal melanoma. In this phase II trial of imatinib... KITLG KITLG EXPRESSION Resitance or Non-Reponse true MMMP detail
No correlation of effect was noted with c-kit, pla... PDGFRA PDGFRA EXPRESSION Resitance or Non-Reponse true MMMP detail
No correlation of effect was noted with c-kit, pla... PDGFRB PDGFRB EXPRESSION Resitance or Non-Reponse true MMMP detail
NCT ID Status Phase Summary Start date Completion date
NCT04578847 Active, not recruiting Phase 2 A Study of REduction And DIscontinuation Treatment of TKI (Imatinib, Nilotinib, Dasatinib and Bosutinib) January 15, 2020 January 15, 2025
NCT03654768 Active, not recruiting Phase 2 Testing the Addition of Ruxolitinib to the Usual Treatment (Tyrosine Kinase Inhibitors) for Chronic Myeloid Leukemia October 24, 2018 July 1, 2028
NCT02881086 Active, not recruiting Phase 3 Optimization of Therapy in Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma by Individualised, Targeted and Intensified Treatment August 2016 July 2025
NCT03722420 Active, not recruiting Phase 3 Randomized Evaluation of Radotinib Versus Imatinib in Phase III Study for Efficacy With Chinese Patients (RERISE China) December 28, 2018 June 30, 2025
NCT04971226 Active, not recruiting Phase 3 A Study of Oral Asciminib Versus Other TKIs in Adult Patients With Newly Diagnosed Ph+ CML-CP October 6, 2021 January 18, 2028
NCT03193281 Active, not recruiting Phase 2 KISS Study: Kinase Inhibition With Sprycel Start up July 17, 2017 December 31, 2025
NCT02365441 Active, not recruiting Phase 2 A Randomised Trial of Imatinib Alternating With Regorafenib Compared to Imatinib Alone for the First Line Treatment of Advanced Gastrointestinal Stromal Tumour (GIST) June 30, 2015 December 31, 2023
NCT03578367 Active, not recruiting Phase 2 Study of Efficacy and Safety of Asciminib in Combination With Imatinib in Patients With Chronic Myeloid Leukemia in Chronic Phase (CML-CP) November 22, 2018 February 6, 2025
NCT03589326 Active, not recruiting Phase 3 A Study of Ponatinib Versus Imatinib in Adults With Acute Lymphoblastic Leukemia October 4, 2018 July 31, 2027
NCT03906292 Active, not recruiting Phase 2 Frontline Asciminib Combination in Chronic Phase CML August 19, 2019 December 2027
NCT04070443 Active, not recruiting Phase 2 Safety and Efficacy of Ponatinib Followed by Imatinib in Patients With Chronic Myelogenous Leukemia in Chronic Phase November 13, 2019 June 1, 2029
NCT00476190 Active, not recruiting Phase 2 ALL Adult Consortium Trial: Adult ALL Trial April 2007 December 2024
NCT04138381 Active, not recruiting Phase 1/Phase 2 Selinexor as Single Agent and With Imatinib in Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (SeliGIST) August 16, 2019 April 16, 2023
NCT02413736 Active, not recruiting Phase 3 Three Versus Five Years of Adjuvant Imatinib as Treatment of Patients With Operable GIST May 2015 May 2033
NCT04330690 Active, not recruiting Phase 3 Treatments for COVID-19: Canadian Arm of the SOLIDARITY Trial March 18, 2020 May 18, 2024
NCT01541709 Active, not recruiting Phase 2 Imatinib Dose Escalation to 800 mg/Day in Korean Patients With Metastatic or Unresectable GIST Harboring KIT Exon 9 Mutation: KENEDI March 2012 December 31, 2024
NCT04394416 Active, not recruiting Phase 3 Trial of Imatinib for Hospitalized Adults With COVID-19 June 2, 2020 December 30, 2024
NCT02272777 Completed Phase 3 A Study of Imatinib and Nilotinib in Patients With Chronic Myelogenous Leukemia in Chronic Phase July 17, 2014 January 30, 2017
NCT00079313 Completed Phase 2 Imatinib (Gleevec(Registered Trademark)) to Treat Chronic Myelomonocytic Leukemia and Atypical Chronic Myelogenous Leukemia January 14, 2004 October 25, 2010
NCT03885830 Completed Precision Dosing of Tyrosine Kinase Inhibitors in CML Patients June 20, 2019 June 15, 2022
NCT03891901 Completed Phase 2 A Clinical Trial of the Safety, Pharmacokinetics and Hematologic Effects of Imatinib on Myelopoiesis in Adults When Given With and Without Isoniazid and Rifabutin October 27, 2020 August 30, 2022
NCT00376467 Completed Phase 2 STI 571 (GLIVEC) in the Treatment of Adult Acute Lymphoblastic Leukemia December 2001 February 2011
NCT00390156 Completed Phase 1 Imatinib, Bevacizumab, and Cyclophosphamide in Patients With Refractory Metastatic Solid Tumors August 2006 January 2011
NCT00116935 Completed Phase 3 Study Comparing 12 Months Versus 36 Months of Imatinib in the Treatment of Gastrointestinal Stromal Tumor (GIST) February 2004 December 2010
NCT00130195 Completed Phase 2 Study of Imatinib-Combined Chemotherapy for BCR-ABL-Positive Acute Lymphoblastic Leukemia (ALL) September 2002 May 2008
NCT00420043 Completed Phase 1 Effect of Food on Bioavailability of Modified Release Formulations of Imatinib September 2006 November 2006
NCT00422825 Completed Phase 1 Effect of Food on Bioavailability of a Modified Release Formulation of Imatinib June 2006 September 2006
NCT00424515 Completed Phase 2 Imatinib in Patients With Mucosal or Acral/Lentiginous Melanoma July 2006 July 2011
NCT00426179 Completed Phase 1/Phase 2 Effects of Imatinib in Subjects With Seasonal Allergic Rhinitis and Who Are Sensitive to Timothy Grass Pollen December 2006 August 2007
NCT00471497 Completed Phase 3 A Study of Imatinib Versus Nilotinib in Adult Patients With Newly Diagnosed Philadelphia Chromosome Positive (Ph+) Chronic Myelogenous Leukemia in Chronic Phase (CML-CP) July 31, 2007 August 21, 2019
NCT00481247 Completed Phase 3 A Phase III Study of Dasatinib vs Imatinib in Patients With Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia September 2007 December 2015
NCT00512902 Completed Phase 1/Phase 2 A Study Using The Experimental Drug Called Imatinib (Gleevec) in Subjects With Systemic Sclerosis August 2007 December 2008
NCT00150072 Completed Phase 2 Efficacy and Safety of Imatinib in Chordoma October 2004 April 2008
NCT00574873 Completed Phase 3 Compare Bosutinib To Imatinib In Subjects With Newly Diagnosed Chronic Phase Philadelphia Chromosome Positive CML February 5, 2008 May 27, 2015
NCT01151852 Completed Phase 3 Rechallenge of Imatinib in GIST Having no Effective Treatment: RIGHT June 2010 March 2013
NCT01188278 Completed Treatment With Second Generation Tyrosine Kinase Inhibitors (2G TKI) Post Imatinib Failure Survey July 2010 January 2013
NCT01275196 Completed Phase 3 Safety and Efficacy of Nilotinib vs. Imatinib in the Treatment of Newly Diagnosed Chinese Ph+ CML-CP Patients April 2011 October 2014
NCT01319981 Completed Phase 2 Hyper-CVAD With Liposomal Vincristine in Acute Lymphoblastic Leukemia March 5, 2013 November 11, 2020
NCT01392469 Completed Phase 3 Pharmacokinetic Effects of QTI571 on Sildenafil and Bosentan in Pulmonary Arterial Hypertension Participants April 20, 2011 October 25, 2012
NCT00193258 Completed Phase 1/Phase 2 Bevacizumab, Erlotinib, and Imatinib in the Treatment of Advanced Renal Cell Carcinoma June 2004 August 2011
NCT01404715 Completed Phase 1 Drug-drug Interaction Study With Metformin and Imatinib October 2011 March 2013
NCT01460693 Completed Phase 3 Comparison of Imatinib Versus Dasatinib in Patients With Newly-diagnosed Chronic Phase Chronic Myeloid Leukaemia August 2008 March 7, 2018
NCT01475110 Completed Observational Study in Adults With Imatinib-resistant/Intolerant Chronic Myeloid Leukemia Treated With Nilotinib September 13, 2012 November 24, 2016
NCT01511289 Completed Phase 3 Radotinib Versus Imatinib in Newly Diagnosed Philadelphia Chromosome and Chronic Myeloid Leukemia Chronic Phase Patients August 2011
NCT01593254 Completed Phase 2 Study of Dasatinib vs Imatinib in Patients With Chronic Myeloid Leukemia (CML) Who Did Not Have Favorable Response to Imatinib September 12, 2012 April 12, 2022
NCT02081378 Completed Phase 1 A Phase I Study of Oral Asciminib (ABL001) in Patients With CML or Ph+ ALL April 24, 2014 March 14, 2023
NCT02130557 Completed Phase 3 A Multicenter Phase 3, Open-Label Study of Bosutinib Versus Imatinib in Adult Patients With Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia July 15, 2014 April 17, 2020
NCT00193349 Completed Phase 2 Gleevec Combined With Camptosar Plus Paraplatin in Previously Untreated Extensive Stage Small Cell Lung Cancer September 2002 December 2007
NCT03454503 Completed Effectiveness and Safety Study of Generic Imatinib in Chronic Myeloid Leukemia Patients in Egypt May 13, 2018 December 28, 2020
NCT05286528 Completed Study to Evaluate Chronic Myeloid Leukemia Treatment Landscape and Real-life Treatment Outcomes in Hungary: Analysis of National Health Insurance Fund Database November 18, 2020 January 31, 2022
NCT02352558 Completed Phase 1 A Study of BBI608 in Adult Patients With Advanced, Refractory Hematologic Malignancies May 2015 May 16, 2019
NCT00237120 Completed Phase 3 Efficacy, Safety and Long-term Prognosis of Imatinib in Patients Newly Diagnosed With Chronic Myelogenous Leukemia (Chronic Phase) November 2002 June 2007
NCT02480608 Completed Phase 1/Phase 2 Treatment of CML Patients With Imatinib and Hydroxyurea (CML2004) April 2004 May 2013
NCT02495519 Completed Phase 2 A Trial of Imatinib for Patients With Aggressive Desmoid Tumor (Aggressive Fibromatosis) April 2014 June 2018
NCT00103844 Completed Phase 2 Dasatinib (BMS-354835) Versus Imatinib Mesylate in Subjects With Chronic Myeloid Leukemia February 2005 March 2008
NCT02977312 Completed Study of Cemivil® (Imatinib) in Chronic Myeloid Leukemia Patients in Jordan August 2012 February 2015
NCT03112603 Completed Phase 3 A Study of Ruxolitinib vs Best Available Therapy (BAT) in Patients With Steroid-refractory Chronic Graft vs. Host Disease (GvHD) After Bone Marrow Transplantation (REACH3) June 29, 2017 December 15, 2022
NCT03170180 Completed Phase 2 Exploratory Study of Drug Sensitivity Prediction Software (IRCR-DReSS) With Patient-derived Tumor Cells of Metastatic Gastric Cancer March 1, 2017 December 28, 2021
NCT03328117 Completed Phase 1 A Study to Investigate the Effects of Imatinib on Pulmonary Vascular Dysfunction in a Human Model of Lung Injury November 13, 2017 March 5, 2018
NCT00632255 Completed Long Term Therapy With Imatinib: Development of Late Side Effects and Compliance to Treatment January 2008 May 2009
NCT00707408 Completed Phase 2 High-Dose Imatinib for Relapsed/Refractory c-Kit Positive Acute Myelogenous Leukemia (AML) February 2004 January 2009
NCT00154336 Completed Phase 2 A Study of Imatinib 400 mg Once Daily in Combination With Methotrexate in the Treatment of Rheumatoid Arthritis. July 2004 August 2005
NCT00760877 Completed Phase 3 Nilotinib Versus Standard Imatinib (400/600 mg Every Day (QD)) Comparing the Kinetics of Complete Molecular Response for Chronic Myelogenous Leukemia in Chronic Phase (CML-CP) Pts With Evidence of Persistent Leukemia by Real-time Quantitative Polymerase Chain Reaction (RQ-PCR) June 2009 July 2015
NCT00760981 Completed Phase 1 A Pilot Study of Imatinib Mesylate in Steroid Refractory Chronic Graft Versus Host Disease September 2008 April 2012
NCT00787384 Completed Phase 2 Efficacy of Imatinib Mesylate in Hypereosinophilic Syndromes October 2004 December 2007
NCT00802841 Completed Phase 3 Randomized Phase Lll Study of Imatinib Dose Optimization vs Nilotinib in CML Patients With Suboptimal Response to Imatinib May 2009 July 2014
NCT00852566 Completed Phase 2 Randomized Study Comparing the Effect of Dasatinib and Imatinib on Malignant Stem Cells in Chronic Myeloid Leukemia March 2009 December 2015
NCT00858806 Completed Phase 2 Intermittent Imatinib Treatment in Chronic Myeloid Leukemia and Philadelphia Chromosome (Ph+CML) Patients Who Achieved a Complete Cytogenetic Response (CCgR) on Standard Imatinib Therapy April 2008 December 2014
NCT00940563 Completed Phase 2 A Prospective, Multicenter Study on Best Clinical Use of Imatinib in the Advanced Gastrointestinal Stromal Tumors March 2002
NCT00973752 Completed Phase 2 Treatment of Older Adults With Acute Lymphoblastic Leukemia August 2009 April 2016
NCT00982488 Completed Phase 2 Long-term Safety of Dasatinib in Patients With Chronic Myelogenous Leukemia or Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia October 2007 December 2014
NCT01025505 Completed Phase 2 Ph+/Bcr-Abl+ ALL Imatinib and Nilotinib Rotational Study June 2012 September 1, 2020
NCT01048320 Completed Phase 1 Gemcitabine and Oxaliplatin (Gem-Ox) Plus Glivec in Gemcitabine-refractory Pancreatic Cancer July 2006 December 2010
NCT00193180 Completed Phase 2 Docetaxel Plus Imatinib Mesylate in Metastatic Breast Cancer May 2005 January 2009
NCT01137916 Completed Phase 2 Study to Evaluate Imatinib in Desmoid Tumors June 2010 December 2016
NCT06175702 Not yet recruiting Treatment Protocol for Newky Diagnosed Adult Ph Positive ALL December 25, 2023 December 25, 2030
NCT04688983 Not yet recruiting Phase 2 Study in Adult Ph-positive ALL January 2021 January 2026
NCT06119789 Not yet recruiting Phase 2 Precision Cancer Therapy in Rare Cancers August 2024 August 2033
NCT05367765 Not yet recruiting Phase 4 A Real World Study of the Efficacy and Safety of Flumatinib Versus Imatinib in Patients With Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase April 30, 2022 April 30, 2028
NCT05895942 Recruiting Exploring the Molecular Mechanism Based on KIT Mutation September 10, 2021 September 10, 2025
NCT04877522 Recruiting Phase 4 Asciminib Roll-over Study August 30, 2022 August 30, 2027
NCT06090669 Recruiting Phase 1 Imatinib to Increase RUNX1 Activity in Participants With Germline RUNX1 Deficiency December 19, 2023 October 30, 2027
NCT06219733 Recruiting Phase 2 Vactosertib and Imatinib Combination in Patients With Advanced Desmoid Tumor/Aggressive Fibromatosis (DT/AF) November 23, 2021 September 15, 2029
NCT05816785 Recruiting Early Phase 1 Pilot Study of Imatinib Cetuximab Combo for H & N Cancer April 18, 2023 September 2025
NCT05493215 Recruiting Phase 2 Imatinib TDM in GIST March 26, 2024 December 2025
NCT05413915 Recruiting Phase 3 Asciminib Used in Consolidation With Imatinib vs. Imatinib to Achieve TFR in CP-CML June 19, 2023 December 2025
NCT05071482 Recruiting Phase 4 Flumatinib Versus Imatinib Combined With Chemotherapy for de Novo Ph+ ALL September 16, 2021 October 30, 2025
NCT04598009 Recruiting Phase 2 Binimetinib and Imatinib for Unresectable Stage III-IV KIT-Mutant Melanoma March 3, 2021 March 31, 2026
NCT02611492 Recruiting Phase 3 A Phase III Randomized Trial of the Reduction of Chemotherapy in Philadelphia Chromosome-positive ALL of Young Adults April 2016 December 2025
NCT04933669 Recruiting Phase 2 Prospective Multicenter Clinical Study of Neoadjuvant Imatinib Mesylate for Gastrointestinal Stromal Tumors September 7, 2021 December 31, 2029
NCT04838041 Recruiting Phase 2 Protocol Number: HJKC3-0003. Treatment Free Remission After Combination Therapy With Asciminib (ABL001) Plus Tyrosine Kinase Inhibitors (TKI) in Chronic Phase Chronic Myeloid Leukemia (CP-CML) Patients Who Relapsed After a Prior Attempt at TKI Discontinuation November 11, 2021 July 2029
NCT06061094 Recruiting Phase 2 Randomized Trial in Adult de Novo Ph Positive ALL With Chemotherapy, Imatinib or Ponatinib, Blinatumomab and SCT July 14, 2023 July 1, 2029
NCT02326311 Recruiting Phase 3 Optimization of TKIs Treatment and Quality of Life in Ph+ CML Patients ≥60 Years in Deep Molecular Response June 10, 2015 December 31, 2023
NCT02735707 Recruiting Phase 3 Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia April 11, 2016 February 2028
NCT05245968 Recruiting Phase 1 A Study of Pimitespib in Combination With Imatinib in Patients With GIST (CHAPTER-GIST-101) December 1, 2021 December 2025
NCT00044304 Recruiting Phase 2 Tyrosine Kinase Inhibition to Treat Myeloid Hypereosinophilic Syndrome September 26, 2002 January 1, 2026
NCT06336395 Recruiting Phase 2 Ma-Spore ALL 2020 Study March 4, 2020 March 2030
NCT04307576 Recruiting Phase 3 A Treatment Study Protocol for Participants 0-45 Years With Acute Lymphoblastic Leukaemia July 13, 2020 June 30, 2032
NCT05220280 Recruiting Phase 4 SOLIDARITY Finland Plus Long-COVID February 6, 2022 December 2025
NCT06051409 Recruiting Phase 3 A Study of Olverembatinib in Patients With Newly Diagnosed Ph+ALL. August 31, 2023 October 31, 2028
NCT00585221 Terminated Phase 2 Study of Imatinib and Peginterferon α-2b in Gastrointestinal Stromal Tumor (GIST) Patients July 2007 July 2009
NCT00115739 Terminated Phase 2 Trial Evaluating Gleevec in Patients With Anaplastic Thyroid Carcinoma February 2004 August 2010
NCT00320190 Terminated Phase 2 Study of Dasatinib in Patients With Chronic Phase Chronic Myeloid Leukemia and a Suboptimal Response to Imatinib August 2006 January 2010
NCT00362466 Terminated Phase 3 A Study of Dasatinib vs. High-Dose Imatinib (600 mg) in Patients With Chronic Phase Chronic Myeloid Leukemia (CML) Who Failed to Achieve Complete Cytogenetic Response After 3-18 Months of Imatinib Therapy April 2007 June 2008
NCT00402662 Terminated Phase 2 A Study of Everolimus in Combination With Imatinib in Metastatic Melanoma February 2006 June 2006
NCT00415857 Terminated Phase 2 Proteinase 3 PR1 Peptide Mixed With Montanide ISA-51 VG Adjuvant and Administered With GM-CSF and PEG-INTRON(R) December 2006 September 2013
NCT00421317 Terminated Phase 2 Imatinib in Adult Patients With Metastatic Ocular Melanoma December 2005 March 2007
NCT00519090 Terminated Phase 3 Nilotinib vs Imatinib in Adult Patients With Philadelphia (Ph+) Chronic Myelogenous Leukemia in Chronic Phase (CML-CP) October 2007 October 2008
NCT00751036 Terminated Phase 3 Nilotinib 800 Mg And Imatinib 800 Mg For The Treatment Of Patients With Gastrointestinal Stromal Tumors (Gist) Refractory To Imatinib 400 Mg June 2009 August 2012
NCT00812240 Terminated Phase 3 Masitinib in First Line Treatment of Gastro-Intestinal Stromal Tumor (GIST) January 2009 July 2018
NCT01117987 Terminated Phase 3 Extension to QTI571A2301 to Evaluate the Long-term Safety, Tolerability and Efficacy of Imatinib in Severe Pulmonary Arterial Hypertension (PAH) April 2010 April 2014
NCT01392495 Terminated Phase 3 Extension to CQTI571A2102 to Evaluate Long-term Safety, Tolerability and Efficacy of Imatinib in Severe Pulmonary Arterial Hypertension (PAH) June 2011 March 2014
NCT02146846 Terminated Population Pharmacokinetics of Imatinib in CML Patients in Iran October 2012 July 2017
NCT02174445 Terminated Phase 3 An Open-label, Randomised Multicenter Phase 3b Study to Determine the Confirmed Rate of Molecular Response ≥ 4 Log (MR4) at Two Years March 2014 October 2019
NCT02462538 Terminated Phase 1/Phase 2 Brentuximab Vedotin and Imatinib in Patients With Relapsed or Refractory ALK+ ALCL November 3, 2015 November 3, 2021
NCT02685046 Terminated Phase 2 Imatinib as Pre-operative Anti-Colon Cancer Targeted Therapy April 2016 September 1, 2019
NCT03343600 Terminated Phase 2 Imatinib for Cytomegalovirus Prophylaxis and Treatment After Allogeneic Hematopoietic Stem Cell Transplantation November 9, 2017 August 31, 2019
NCT03878524 Terminated Phase 1 Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial April 1, 2020 December 10, 2020
NCT00149136 Unknown status Phase 2 Treatment of Philadelphia-Positive Acute Lymphocytic Leukemia (Ph+ ALL) in the Elderly With Imatinib Mesylate (STI571) and Chemotherapy. August 2002
NCT03697668 Unknown status Phase 2 Triple Antimalarial Combination to Accelerate the Parasite Clearance and to Prevent the Selection of Resistant Parasites September 17, 2017 December 31, 2019
NCT03515018 Unknown status Phase 3 Evaluation of the Therapeutic Effect of HU Pulse Therapy for CML Patients May 1, 2018 May 1, 2020
NCT02894645 Unknown status Phase 4 Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study October 2008
NCT02638428 Unknown status Phase 2 Genomics-Based Target Therapy for Children With Relapsed or Refractory Malignancy December 2015 December 2023
NCT02602314 Unknown status Phase 4 Sustained Treatment-free Remission in BCR-ABL+ Chronic Myeloid Leukemia November 11, 2016 February 2024
NCT02576080 Unknown status Phase 3 Efficacy of Imatinib in Patients With Intermediate-risk Gastrointestinal Stromal Tumor With a High-risk Genomic Grade Index October 2015 October 2020
NCT02461849 Unknown status Phase 2 Patients With Refractory, Metastatic Cancer Harboring KIT Mutation or Amplification to Investigate the Clinical Efficacy and Safety of Imatinib Therapy April 4, 2014 December 2022
NCT02363361 Unknown status Phase 2 Treatment of Cervical Spinal Cord Injury With Imatinib - a Safety and Feasibility Study April 2018 December 2021
NCT02317159 Unknown status Phase 4 Efficacy and Safety of Imatinib Mesylate as First-line Treatment for the Patients With Chronic Phase of Chronic Myeloid Leukemia February 2015 July 2017
NCT02013089 Unknown status N/A A Pilot Study of Genomic Sequencing Guided Individualized Therapy in Gastrointestinal Cancers, GITIC Study December 2013 December 2017
NCT01804985 Unknown status Phase 2 De- Escalation and Stopping Treatment of Imatinib, Nilotinib or sprYcel in Chronic Myeloid Leukaemia December 2013 May 2018
NCT01782508 Unknown status Phase 2 A Phase II Study of Imatinib Versus Interferon as Adjuvant Therapy in KIT-mutated Melanoma August 2012 December 2014
NCT00180921 Unknown status Phase 2 Study of Imatinib (Glivec) in Patients With Adenoid Cystic Carcinoma of the Head and Neck July 2004
NCT03844360 Unknown status Phase 4 Dose Individualization of Antineoplastic Drugs and Anti-Infective Drug in Children With Hematoplastic Disease January 31, 2016 December 31, 2021
NCT01503502 Unknown status Phase 2 A Phase II Study of Flumatinib Versus Imatinib to Treat Philadelphia Chromosome Positive Chronic Myelogenous Leukemia August 2011 December 2014
NCT01491763 Unknown status Phase 4 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE January 2008 December 2022
NCT00573326 Unknown status Phase 2 Low-Dose Oral Imatinib for Scleroderma Pulmonary Involvement February 2009 June 2010
NCT00327262 Unknown status Phase 3 Comparing Imatinib Standard Dose With Imatinib High Dose Induction in Pretreated Chronic Myeloid Leukemia (CML) Patients in Chronic Phase January 2004 December 2008
NCT00199186 Unknown status Phase 2 Study Comparing Imatinib With Chemotherapy as Induction in Elderly Patients With Philadelphia Positive Acute Lymphoblastic Leukemia (ALL) March 2002
NCT01568645 Withdrawn Phase 1 Imatinib and Carvedilol for High Blood Pressure in the Lungs in Adults With Sickle Cell Disease March 2, 2012 December 11, 2012
NCT01188889 Withdrawn Phase 1/Phase 2 RAD001 in Patients With Chronic Phase Chronic Myeloid Leukemia w/ Molecular Disease. September 2013 December 2017