Annotation Detail
Information
- Associated Genes
- KIT
- Associated Variants
- KIT WILD_TYPE
- Source Database
- MMMP
- Description
- The melanoma cell lines showed a heterogenous expression of the imatinib target molecules without functional mutations in the corresponding amino-acid sequences. In vitro imatinib treatment of the cell lines showed no antiproliferative effect
- MMMP State
- wild type
- MMMP Molecule
- KIT
- MMMP Molecule Alias
- c-KIT
- MMMP Relationship
- resistance to
- MMMP Drug
- Imatinib
- MMMP Drug Alias
- Gleevec (R)
- MMMP Model
- 3
- MMMP Reference
- Ugurel S, Br J Cancer 2005, 92:1398-405
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Imatinib | Resitance or Non-Reponse | true |