Annotation Detail
Information
- Associated Genes
- ABL1
- Associated Variants
- ABL1 p.Thr334Ile (p.T334I) ABL1 p.Thr334Ile (p.T334I)
- Associated Disease
- acute lymphoblastic leukemia
- Source Database
- CIViC Evidence
- Description
- Bone marrow mononuclear cells (BM MNCs) isolated from three acute lymphoblastic leukemia patients with the BCR-ABL1 T315I variant. Patients were pretreated with various chemotherapeutics and dasatinib. The patients' cells were sensitive to Ponatinib and Axitinib and insensitive to Nilotinib, Imatinib, and Dasatinib using drug sensitivity scoring detailed in a referenced paper. Additionally, in a proliferation assay, T315I variants were resistant to imatinib.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/7778
- Gene URL
- https://civic.genome.wustl.edu/links/genes/4
- Variant URL
- https://civic.genome.wustl.edu/links/variants/2
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Acute Lymphoblastic Leukemia
- Evidence Direction
- Supports
- Drug
- Imatinib,Dasatinib,Nilotinib
- Evidence Level
- D
- Clinical Significance
- Resistance
- Pubmed
- 25686603