acute lymphoblastic leukemia (Cancer)

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Information
Disease name
acute lymphoblastic leukemia
Disease ID
DOID:9952
Description
"A acute leukemia that is characterized by over production of lymphoblasts." [url:http\://www.cancer.gov/dictionary?CdrID=46332]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
Genes Mutation Description Source Links
NCT ID Status Phase Summary Start date Completion date
NCT04340154 Active, not recruiting Phase 2 Study of Sequential CAR-T Cell Treating Leukemia Children May 1, 2020 November 1, 2024
NCT03178617 Active, not recruiting N/A High-Intensity Parent Intervention Program in Improving Learning and School Functioning in Latino Children With Acute Leukemia or Lymphoblastic Lymphoma February 14, 2018 December 15, 2024
NCT03147612 Active, not recruiting Phase 2 Low-Intensity Chemotherapy, Ponatinib and Blinatumomab in Treating Patients With Philadelphia Chromosome-Positive and/or BCR-ABL Positive Acute Lymphoblastic Leukemia February 8, 2018 February 28, 2025
NCT03434730 Active, not recruiting Phase 2 Tocilizumab for the Prevention of Graft Versus Host Disease After Cord Blood Transplantation February 7, 2018 February 7, 2025
NCT01494103 Active, not recruiting Phase 1 Administration of Donor T Cells With the Caspase-9 Suicide Gene November 2011 May 2029
NCT02003222 Active, not recruiting Phase 3 Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia May 19, 2014 December 4, 2024
NCT01503632 Active, not recruiting Phase 3 Assessing Compliance With Mercaptopurine Treatment in Younger Patients With Acute Lymphoblastic Leukemia in First Remission February 21, 2012 December 31, 2029
NCT03821610 Active, not recruiting Phase 2 A Comparison of Reduced Dose Total Body Irradiation (TBI) and Cyclophosphamide With Fludarabine and Melphalan Reduced Intensity Conditioning in Adults With Acute Lymphoblastic Leukaemia (ALL) in Complete Remission. (ALL-RIC) November 22, 2018 November 22, 2027
NCT05515029 Active, not recruiting Phase 3 Preventing of GVHD With Post-transplantation Cyclophosphamide, Abatacept, Vedolizumab and Calcineurin Inhibitor at Patients With Hemoblastosis August 23, 2022 October 16, 2026
NCT01044069 Active, not recruiting Phase 1 Precursor B Cell Acute Lymphoblastic Leukemia (B-ALL) Treated With Autologous T Cells Genetically Targeted to the B Cell Specific Antigen CD19 January 5, 2010 January 2025
NCT00003861 Active, not recruiting Diagnostic Study of Patients With Acute Lymphoblastic Leukemia or Acute Promyelocytic Leukemia April 1999
NCT00476190 Active, not recruiting Phase 2 ALL Adult Consortium Trial: Adult ALL Trial April 2007 December 2024
NCT03117751 Active, not recruiting Phase 2/Phase 3 Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma March 29, 2017 March 31, 2028
NCT03333486 Active, not recruiting Phase 2 Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer December 7, 2017 August 28, 2024
NCT00719888 Active, not recruiting Phase 2 Umbilical Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With Hematologic Disease November 18, 2005 December 22, 2024
NCT04329325 Active, not recruiting Phase 2 Blinatumomab and Tyrosine Kinase Inhibitor Therapy in People With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia March 30, 2020 March 2025
NCT02143414 Active, not recruiting Phase 2 Blinatumomab and Combination Chemotherapy or Dasatinib, Prednisone, and Blinatumomab in Treating Older Patients With Acute Lymphoblastic Leukemia June 30, 2015 October 23, 2024
NCT00048958 Active, not recruiting Cytogenetic Studies in Acute Leukemia and Multiple Myeloma June 1984
NCT05687032 Active, not recruiting Phase 4 A Study of Inotuzumab Ozogamicin in Chinese Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia February 24, 2023 November 7, 2025
NCT03114865 Active, not recruiting Phase 1/Phase 2 A Study of Blinatumomab in Patients With Pre B-cell ALL and B-cell NHL as Post-allo-HSCT Remission Maintenance September 5, 2017 June 30, 2025
NCT01574274 Active, not recruiting Phase 2 SC-PEG Asparaginase vs. Oncaspar in Pediatric Acute Lymphoblastic Leukemia (ALL) and Lymphoblastic Lymphoma June 2012 July 2027
NCT01593488 Active, not recruiting Phase 2 Liposomal Cytarabine in the Treatment of Central Nervous System Resistant or Relapsed Acute Lymphoblastic Leukemia in Children March 2012 December 2024
NCT05774990 Active, not recruiting Study Protocol: Study on Incidence and Risk Factors of Mold Infections in Children During Leukemia Treatment April 1, 2023 August 2025
NCT03301168 Active, not recruiting Phase 1/Phase 2 Study of Gene Modified Donor T-cells Following TCR Alpha Beta Positive Depleted Stem Cell Transplant April 2014 May 2034
NCT02256137 Active, not recruiting A Longitudinal Assessment of Frailty in Young Adult Survivors of Childhood Cancer October 8, 2014 August 17, 2025
NCT03642626 Active, not recruiting MT2017-45: CAR-T Cell Therapy for Heme Malignancies December 18, 2018 June 1, 2028
NCT04233346 Active, not recruiting Phase 2 The Study for CML Who Failed Prior TKIs or With T315I Mutation or Ph+ ALL Who Failed Prior TKIs or With T315I Mutation July 9, 2020 December 31, 2025
NCT02996773 Active, not recruiting Phase 1 Haploidentical BMT With Post-Transplant Cyclophosphamide and Bendamustine November 29, 2016 August 25, 2025
NCT04191187 Active, not recruiting Phase 2 Reduced Intensity Flu/Mel/TBI Conditioning for HAPLO HCT Patients With Hematologic Malignancies December 6, 2019 February 2025
NCT00557193 Active, not recruiting Phase 3 Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia January 15, 2008 June 28, 2024
NCT05326516 Active, not recruiting Phase 1 A Study of Revumenib in Combination With Chemotherapy in Participants With R/R Acute Leukemia March 9, 2022 June 2024
NCT02315612 Active, not recruiting Phase 1 Anti-CD22 Chimeric Receptor T Cells in Pediatric and Young Adults With Recurrent or Refractory CD22-expressing B Cell Malignancies December 12, 2014 June 1, 2040
NCT05972577 Active, not recruiting N/A Geriatric Optimization Plan to Improve Survival in Older Adult Allogeneic Hematopoietic Cell Transplant Candidates, OTIS Study June 2, 2021 December 31, 2024
NCT01139970 Active, not recruiting Phase 1 Veliparib and Temozolomide in Treating Patients With Acute Leukemia May 21, 2010 February 22, 2025
NCT03904134 Active, not recruiting N/A Clinical Transplant-Related Long-term Outcomes of Alternative Donor Allogeneic Transplantation (BMT CTN 1702) June 14, 2019 March 2025
NCT03844048 Active, not recruiting Phase 3 An Extension Study of Venetoclax for Subjects Who Have Completed a Prior Venetoclax Clinical Trial September 6, 2019 May 27, 2025
NCT03204916 Active, not recruiting Cancer Care Delivery in Adolescent and Young Adult Patients With Acute Lymphoblastic Leukemia December 18, 2017 September 30, 2024
NCT04105530 Active, not recruiting N/A Transcranial Direct Current Stimulation of the Temporal Cortex in Survivors of Childhood Acute Lymphoblastic Leukemia (ALL) November 18, 2019 September 2024
NCT02881086 Active, not recruiting Phase 3 Optimization of Therapy in Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma by Individualised, Targeted and Intensified Treatment August 2016 July 2025
NCT02443831 Active, not recruiting Phase 1 CARPALL: Immunotherapy With CD19/22 CAR T-cells for CD19+ Haematological Malignancies April 2016 December 31, 2036
NCT05386576 Active, not recruiting Early Phase 1 A Study of Venetoclax in Combination With Chemotherapy to Treat Newly Diagnosed Acute Lymphoblastic Leukemia (ALL) June 16, 2022 May 2025
NCT00136435 Active, not recruiting Phase 2 A Study in Adults With Untreated Acute Lymphoblastic Leukemia June 2002 July 2024
NCT02494882 Active, not recruiting Phase 1 Adding Ruxolitinib to a Combination of Dasatinib Plus Dexamethasone in Remission Induction Therapy in Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Patients Aged 40 Years or Older June 29, 2015 June 2025
NCT01744223 Active, not recruiting Phase 1/Phase 2 Safety Study of Gene Modified Donor T-cells Following Partially Mismatched Stem Cell Transplant March 2013 October 2032
NCT01424982 Active, not recruiting Phase 2 Combination Chemotherapy and Ponatinib Hydrochloride in Treating Patients With Acute Lymphoblastic Leukemia October 5, 2011 October 31, 2025
NCT04060277 Active, not recruiting Phase 2 Triplex Vaccine in Preventing CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplantation November 27, 2019 April 7, 2030
NCT04473911 Active, not recruiting Phase 1 Haplo Peripheral Blood Sct In GVHD Prevention August 14, 2020 October 2024
NCT00792948 Active, not recruiting Phase 2 Combination Chemotherapy With or Without Donor Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia September 1, 2009 January 6, 2025
NCT00710892 Active, not recruiting Phase 1 CASPALLO: Allodepleted T Cells Transduced With Inducible Caspase 9 Suicide Gene December 2008 July 2026
NCT01190930 Active, not recruiting Phase 3 Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma August 9, 2010 March 31, 2028
NCT02553460 Active, not recruiting Phase 1/Phase 2 Total Therapy for Infants With Acute Lymphoblastic Leukemia (ALL) I January 29, 2016 October 2031
NCT04943952 Approved for marketing JZP458 - Recombinant Erwinia Asparaginase for Treatment of ALL / LBL Patients With Hypersensitivity to E. Coli-derived Asparaginase
NCT05776134 Available Expanded Access Study for the Treatment of Patients With Commercially Out-of-Specification Brexucabtagene Autoleucel
NCT00552825 Completed Pulmonary Function at Presentation and Follow-up in Hemato-Oncology 3-7 Years Old Children October 2005 October 2006
NCT00560794 Completed Phase 2 Phase II Study of the BiTE® Blinatumomab (MT103) in Patients With Minimal Residual Disease of B-precursor Acute Lymphoblastic Leukemia (ALL) January 2008 November 2014
NCT00576472 Completed Phase 4 Learning Impairments Among Survivors of Childhood Cancer January 2000 March 2010
NCT04888468 Completed Phase 1 Phase I Study of pCAR-19B in the Treatment of CD19-positive Relapsed/Refractory B-ALL in Children and Adolescents November 5, 2019 September 1, 2021
NCT00600977 Completed Phase 2 Liposomal Anthracyclin in the Treatment of Elderly ALL March 2002 October 2006
NCT00602134 Completed N/A Bioequivalence Study of 6-Mercaptopurine Under Fasting Conditions November 2002 November 2002
NCT00606216 Completed Structural Imaging and Cognitive Functions in Adult Stem Cell Transplant Recipients Treated With Chemotherapy Alone or in Combination With Radiotherapy January 2007 December 2015
NCT04843514 Completed TDM of Asparaginase in ALL2008 April 1, 2021 January 31, 2024
NCT00659425 Completed Phase 1 CAT-8015 in Children, Adolescents and Young Adults With Acute Lymphoblastic Leukemia or Non-Hodgkin's Lymphoma September 2008 December 2014
NCT00664131 Completed Neurologic Morbidity and Disability in Acute Lymphoblastic Leukemia Survivors August 2005 October 2008
NCT00671034 Completed Phase 3 Calaspargase Pegol or Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia July 21, 2008 March 31, 2021
NCT00671658 Completed Phase 2 Modified Hyper-CVAD (Cyclophosphamide, Vincristine, Adriamycin, and Dexamethasone) Program for Acute Lymphoblastic Leukemia November 2002 July 2013
NCT04843150 Completed Pharmacokinetics and Immunogenicity of the First Doses of PEG-Asparaginase -An ALLTogether Pilot Study July 1, 2020 October 1, 2023
NCT00678275 Completed Phase 3 Chronic Graft-versus-host Disease (cGvHD) Prophylaxis With or Without ATG Prior to Stem Cell Transplantation (SCT) From HLA-identical Siblings in Patients With Acute Leukemia October 2006 March 2015
NCT00682305 Completed Phase 2 Allogeneic Stem Cell Transplantation (SCT) With Treosulfan, VP-16 and Cyclophosphamid for Patients With Acute Lymphoblastic Leukemia (ALL) March 2007 August 2013
NCT00686556 Completed Phase 1 Total Marrow Irradiation for Refractory Acute Leukemia August 2012 December 2016
NCT00693602 Completed Phase 1 Compassionate Use of Erwinase For Pediatric Patients With Acute Lymphoblastic Leukemia Or Non Hodgkins Lymphoma June 2006 December 2011
NCT00697671 Completed Phase 1 Pilot Study of Haploidentical Natural Killer Cell Infusions for Poor Prognosis Non-AML Hematologic Malignancies March 2007 May 2013
NCT00718757 Completed Phase 1 Irinotecan, Vincristine, and Dexamethasone In Children With Relapsed And/Or Refractory Hematologic Malignancies January 2005 January 2009
NCT00719147 Completed AVN of Weight-Bearing Joints In Patients With Hematologic Malignancies Treated With Dexamethasone Or Prednisone July 2001 July 2005
NCT00720109 Completed Phase 2/Phase 3 Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia July 14, 2008 March 31, 2020
NCT00723099 Completed Phase 2 Donor Umbilical Cord Blood Transplant in Treating Patients With Hematologic Cancer June 25, 2008 July 31, 2018
NCT00723346 Completed Phase 1/Phase 2 Administration of Allogenic Red Blood Cells Loaded L-asparaginase in Cases of Relapse of Acute Lymphoblastic Leukaemia January 2006 March 2009
NCT00726934 Completed N/A The Effectiveness of the Neutropenic Diet in Pediatric Oncology Patients September 2007 January 2017
NCT00750659 Completed Phase 2 Nilotinib Pre and Post Allogeneic Stem Cell Transplantation July 2009 April 2016
NCT00766311 Completed N/A Aerobic and Strengthening Exercise for Acute Leukemia January 2008 December 2011
NCT04825548 Completed Post-thrombotic Syndrome After Deep Venous Thrombosis (DVT) in Patients Treated According to the NOPHO ALL2008 Protocol July 1, 2020 December 31, 2023
NCT00784017 Completed Phase 3 Comparative Efficacy and Safety of Two Asparaginase Preparations in Children With Previously Untreated Acute Lymphoblastic Leukaemia October 2008 October 2012
NCT00789776 Completed Phase 1/Phase 2 Fludarabine Phosphate, Cyclophosphamide, Total-Body Irradiation, and Donor Bone Marrow Transplant Followed by Donor Natural Killer Cell Therapy, Mycophenolate Mofetil, and Tacrolimus in Treating Patients With Hematologic Cancer October 13, 2008 May 2017
NCT04699162 Completed Efficacy of Intermediate and High Intensity Regimens in Patients With Relapsed Acute Lymphoblastic Leukemia July 1, 2016 December 31, 2020
NCT00795756 Completed Phase 2/Phase 3 Intrathecal DepoCyte and Lineage-targeted Minimal Residual Disease-oriented Therapy of Acute Lymphoblastic Leukemia January 2008 October 2013
NCT00795886 Completed Phase 2 Rapamycin for Immunosuppression and B Cell Modulation Post Stem Cell Transplant for Acute Lymphoblastic Leukemia (ALL) August 2005 March 2010
NCT04666025 Completed SARS-CoV-2 Donor-Recipient Immunity Transfer September 23, 2020 May 5, 2023
NCT00807677 Completed Phase 1 A Phase 1 Dose Escalation Study of TAK-901 in Subjects With Advanced Hematologic Malignancies March 2009 March 2013
NCT00816049 Completed Phase 3 ALL2008 Protocol for Childhood Acute Lymphoblastic Leukemia (ALL) - 6MP Consolidation Therapy January 2009 March 2, 2016
NCT00819351 Completed Phase 3 ALL2008 Protocol for Childhood Acute Lymphoblastic Leukemia Intermittent Versus Continuous PEG Asparaginase January 1, 2009 March 2, 2016
NCT04629430 Completed N/A Effects of Prebiotics on Gut Microbiome in Patients Undergoing HSCT February 19, 2021 October 28, 2022
NCT00853008 Completed Phase 4 Treatment of High Risk Adult Acute Lymphoblastic Leukemia January 2003 December 2012
NCT00861679 Completed N/A Therapy Protocol Acute Lymphoblastic Leukemia Stem Cell Transplantation International January 2007 September 2014
NCT00862719 Completed Phase 2 Sitagliptin Umbilical Cord Blood Transplant Study March 2009 February 2015
NCT04524455 Completed Phase 1 Blinatumomab in Combination With AMG 404 for the Treatment of Adults With Relapsed or Refractory B Cell Precursor ALL October 2, 2020 January 24, 2023
NCT00866307 Completed Phase 1 Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia (Closed to Accrual 4-22-2011) February 23, 2009 March 31, 2021
NCT00874562 Completed Phase 1 Rapamycin in Relapsed Acute Lymphoblastic Leukemia July 2007 April 2016
NCT00890656 Completed Phase 2 Study of Augmented Hyper-CVAD in Acute Lymphoblastic Leukemia Salvage June 2003 January 2011
NCT04452604 Completed Multicentric Registry of Patients With Acute Leukemia Infected by COVID-19 September 11, 2020 July 7, 2021
NCT00902213 Completed N/A Physical Activity to Modify Sequelae and Quality of Life in Childhood Acute Lymphoblastic Leukemia November 2009 May 2015
NCT00911066 Completed Phase 1 MLN4924 for the Treatment of Acute Myelogenous Leukemia, Myelodysplastic Syndrome, and Acute Lymphoblastic Leukemia June 2009 October 2013
NCT00930098 Completed Phase 2 A Phase II, Open-Label Study of Clofarabine in Paediatric Patients With Refractory/Relapsed Acute Lymphoblastic Leukaemia December 2003 July 2007
NCT00940524 Completed Phase 1 Induction Therapy With Cytarabine, High-Dose Mitoxantrone and Dasatinib for Patients With Philadelphia-Chromosome Positive (Ph+) Acute Lymphoblastic Leukemia July 2009 April 2014
NCT00945828 Completed N/A Assessing the Effectiveness of Individual Education Plans for Childhood Cancer Survivors January 2003 October 2010
NCT00954720 Completed Observational Study of Iron Overload in Stem Cell Transplantation March 2008 May 2011
NCT04323657 Completed Phase 1/Phase 2 TC-110 T Cells in Adults With Relapsed or Refractory Non-Hodgkin Lymphoma or Acute Lymphoblastic Leukemia March 27, 2020 February 24, 2023
NCT00964873 Completed Phase 1 A Phase 1 Study of the HSP90 Inhibitor, STA-9090 in Subjects With Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Blast-phase Chronic Myelogenous Leukemia August 2009 August 2011
NCT04187248 Completed The Association Between Asparaginase Enzyme Activity Levels and Toxicities in Childhood Acute Lymphoblastic Leukaemia in NOPHOALL 2008 July 1, 2008 March 1, 2017
NCT04145531 Completed Phase 2/Phase 3 An Open-Label Study of JZP-458 (RC-P) in Patients With Acute Lymphoblastic Leukemia (ALL)/Lymphoblastic Lymphoma (LBL) December 27, 2019 July 13, 2022
NCT00973752 Completed Phase 2 Treatment of Older Adults With Acute Lymphoblastic Leukemia August 2009 April 2016
NCT04082286 Completed Phase 1 Yttrium-90 Anti CD66 Monoclonal Antibody in Childhood Relapsed/Refractory Leukaemia May 2016 May 14, 2020
NCT00990249 Completed Phase 2 Busulfan Plus Clofarabine Followed by Allogeneic Hematopoietic Stem Cell Transplantation October 2009 May 2016
NCT04067518 Completed Phase 2 A Clinical Study of SHP674 (Pegaspargase) in Participants With Newly Diagnosed, Untreated Acute Lymphoblastic Leukemia October 17, 2019 February 4, 2022
NCT01004497 Completed Phase 2 First-line Dasatinib Plus Conventional Chemotherapy in Adults With Newly Diagnosed Ph-Positive ALL March 2010 April 2015
NCT01014195 Completed Risk of Psychopathology and Neurocognitive Impairment in Leukemia Survivors January 2010 October 2014
NCT01015261 Completed Phase 2/Phase 3 Allogenic Bone Marrow Transplantation (BMT) Compare With Cytoreduction and Chemotherapy in Acute Lymphoblastic Leukemia (ALL) Patients October 2008 September 2010
NCT01025778 Completed Phase 2 Haploidentical Stem Cell Transplantation for Children With Therapy Resistant Leukemia December 2009 December 2012
NCT01036009 Completed Phase 2 A Study of Withdrawal of Immunosuppression and Donor Lymphocyte Infusions Following Allogeneic Transplant for Pediatric Hematologic Malignancies October 2009 July 2015
NCT01047020 Completed Motor Proficiency And Physical Activity in Adult Survivors of Childhood Acute Lymphoblastic Leukemia (ALL) June 2009 April 2013
NCT01051154 Completed Phase 2 Effect of Enteral Docosahexaenoic Acid Administration in Children With Acute Lymphoblastic Leukemia September 2010 August 2016
NCT01068301 Completed Phase 1 A Pediatric Study of a Plerixafor Containing Regimen In Second Allogeneic Stem Cell Transplantation May 2010 October 2013
NCT01077544 Completed Phase 1 A Pharmacokinetic (PK) Study of Nilotinib in Pediatric Patients With Philadelphia Chromosome-positive (Ph+) Chronic Myelogenous Leukemia (CML) or Acute Lymphoblastic Leukemia (ALL) April 14, 2011 July 1, 2015
NCT04015882 Completed N/A Effects of Exercises on Total Body Health in Children With Acute Lymphoblastic Leukemia August 1, 2019 December 31, 2019
NCT04014764 Completed Collect and Assess Tissue Samples From Subjects With Hematologic Malignancy December 15, 2019 March 31, 2022
NCT01094392 Completed Hemostasis During Asparaginase Treatment in Acute Lymphoblastic Leukemia(ALL) March 2010 October 10, 2018
NCT01095926 Completed Phase 2 Pharmacokinetic Study of Doxorubicin in Children With Cancer May 2010 May 2013
NCT04007601 Completed N/A Neurostimulation In Adult Survivors of Childhood Acute Lymphoblastic Leukemia (ALL) December 12, 2019 June 21, 2023
NCT01110473 Completed Phase 1 ABT-348 as Monotherapy and in Combination With Azacitidine to Treat Advanced Hematologic Malignancies April 2010 June 2013
NCT01119066 Completed Phase 2 HLA-Compatible Related or Unrelated Donors With CD34+ Enriched, T-cell Depleted Peripheral Blood Stem Cells Isolated by the CliniMACS System in the Treatment of Patients With Hematologic Malignancies May 3, 2010 March 30, 2021
NCT01134575 Completed Phase 2 CMC-544 in Relapsed Refractory Acute Lymphoblastic Leukemia (ALL) June 4, 2010 April 18, 2018
NCT01142427 Completed Risk-Based Classification System of Patients With Newly Diagnosed Acute Lymphoblastic Leukemia August 9, 2010 September 30, 2023
NCT03964259 Completed Phase 1 Reduced IV Fluids to Improve Clearance of HDMTX in Children w/Lymphoma or Acute Lymphoblastic Leukemia October 2, 2019 December 28, 2022
NCT01148927 Completed Quality of Life Study for Adult Patients With Acute Lymphoblastic Leukemia November 2009 October 2012
NCT01149915 Completed Phase 1 Study of Hypoxia-Activated Prodrug TH-302 to Treat Advanced Leukemias June 2010 August 2013
NCT01159028 Completed Phase 1 Clinical Trial of BP1001 (L-Grb-2 Antisense Oligonucleotide) in CML, AML, ALL & MDS June 2010 March 30, 2017
NCT01169012 Completed Phase 1 PK Study of Oral and IV Clofarabine in High Risk Myelodysplasia+Acute Leukemias September 2010 January 2013
NCT01184885 Completed Early Phase 1 A Pilot Study to Determine the Safety and Tolerability of Sirolimus Given With Hyper-CVAD Chemotherapy July 2010 April 2013
NCT03919526 Completed Phase 1 Anti-CD19/CD22 Bispecific Chimeric Antigen Receptor(CAR)-T Cell Therapy for Measurable Residual Disease(MRD) Positive ALL August 11, 2019 November 1, 2023
NCT01188798 Completed Phase 3 Methotrexate or Pentostatin for Graft-versus-host Disease Prophylaxis in Risk-adapted Allogeneic Bone Marrow Transplantation for Hematologic Malignancies September 2010 February 2012
NCT01196013 Completed Phase 1 A Study of Clofarabine in Japanese Paediatric Patients With Relapsed or Refractory Acute Lymphoblastic Leukaemia August 2010 May 2011
NCT01217996 Completed N/A Computerized Intervention for Amelioration of Cognitive Late Effects Among Childhood Cancer Survivors October 2010 November 2013
NCT03803670 Completed Clinical Significance of Occult Central Nervous System Disease In Adult Acute Lymphoblastic Leukemia January 1, 2007 January 10, 2019
NCT01231412 Completed Phase 3 Graft-Versus-Host Disease Prophylaxis in Treating Patients With Hematologic Malignancies Undergoing Unrelated Donor Peripheral Blood Stem Cell Transplant November 2010 June 30, 2017
NCT01253720 Completed N/A PACE CALL: Weight Loss Study for Childhood Leukemia Survivors June 2008 June 2013
NCT01256398 Completed Phase 2 Dasatinib Followed by Stem Cell Transplant in Treating Older Patients With Newly Diagnosed Acute Lymphoblastic Leukemia December 14, 2010 November 15, 2021
NCT01266083 Completed Phase 2 WT-1 Analog Peptide Vaccine in Acute Myeloid Leukemia (AML) or Acute Lymphoblastic Leukemia (ALL) December 2010 February 2018
NCT01279473 Completed Phase 1/Phase 2 Study to Evaluate Nilotinib in Adult Patients With Imatinib-resistant or Imatinib-intolerant Chronic Myelogenous Leukemia (CML), or Relapse/Refractory Ph+ Acute Lymphoblastic Leukemia (ALL) (Extension Study) August 2005
NCT01297543 Completed Phase 1/Phase 2 Safety Study of Human Myeloid Progenitor Cells (CLT-008) After Chemotherapy for Leukemia March 2011 January 2015
NCT03677596 Completed Phase 4 A Study Of Two Inotuzumab Ozogamicin Doses in Relapsed/ Refractory Acute Lymphoblastic Leukemia Transplant Eligible Patients July 1, 2019 May 26, 2023
NCT01324180 Completed Phase 1 Vincristine, Dexamethasone, Doxorubicin, and PEG-asparaginase (VPLD) and Metformin for Relapsed Childhood Acute Lymphoblastic Leukemia (ALL) July 18, 2011 July 27, 2017
NCT01324336 Completed Comparative Pharmacokinetics of a Compounded 6-mercaptopurine Liquid Formulation Preparation and Tablets July 2011 December 2013
NCT03581045 Completed Postural Control Under Different Cognitive Loads in Adult Survivors of Acute Lymphoblastic Leukemia and Age-Matched Healthy Individuals October 2, 2018 April 27, 2021
NCT03575325 Completed Phase 2 Vyxeos(CPX-351) in Adults w R/R Acute Lymphoblastic Leukemia October 11, 2018 September 14, 2023
NCT03555955 Completed Phase 1 A Trial to Evaluate the Potential Impact of Renal Impairment on the Pharmacokinetics and Safety of CPX-351 November 20, 2018 May 26, 2021
NCT01358253 Completed Phase 4 Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia December 2010 December 2012
NCT01363128 Completed Phase 2 Combination Chemotherapy and Ofatumumab in Treating Patients With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma July 12, 2011 April 8, 2020
NCT01364363 Completed N/A Unrelated Donor Stem Cell Transplantation March 2005 July 2015
NCT03476239 Completed Phase 3 Efficacy and Safety of the BiTE Antibody Blinatumomab in Chinese Adult Subjects With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia (ALL) October 18, 2017 April 8, 2021
NCT01380587 Completed Utility of XCL1 as a Prognostic Marker in Acute Lymphoblastic Leukemia November 2010 September 2012
NCT01393249 Completed PEG-Asparaginase Associated Pancreatitis, Hepatotoxicity and Hyperlipidemia in Children With ALL July 2011 June 2014
NCT01439217 Completed Endothelial Function, Arterial Stiffness and Components June 2011 February 2013
NCT01457040 Completed Phase 2/Phase 3 Intensified Conditioning Regimen With High-Dose-Etoposide for Allo-HSCT for Adult Acute Lymphoblastic Leukemia October 2011 December 2016
NCT01462253 Completed Phase 2 Clofarabine-cyclophosphamide as Salvage Therapy for Refractory and Relapsed Acute Lymphoblastic Leukemia (ALL) Adults October 2012 March 11, 2017
NCT01466179 Completed Phase 2 Clinical Study With Blinatumomab in Patients With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia (ALL) December 2011 January 2017
NCT01470924 Completed Acute Lymphoblastic Leukemia Relapse in Sweden 2003-2007 January 2003 June 2011
NCT01471782 Completed Phase 1/Phase 2 Clinical Study With Blinatumomab in Pediatric and Adolescent Patients With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia January 2012 May 2016
NCT01476462 Completed Second Malignant Neoplasms After Childhood ALL Therapy January 2009 December 2011
NCT03471416 Completed Nutritional Status in Children With ALL in Guatemala May 1, 2019 September 1, 2022
NCT01506453 Completed Phase 2 Therapeutic Interventions For Pain Induced By Vincristine Treatment For Childhood Acute Lymphoblastic Leukemia (ALL) January 24, 2012 January 2, 2018
NCT03429387 Completed N/A PET/CT and Bacterial/Fungal PCR in High Risk Febrile Neutropenia January 8, 2018 January 23, 2021
NCT01517035 Completed Phase 1/Phase 2 Improving Blood Stem Cell Collection and Transplant Procedures January 13, 2012 March 29, 2017
NCT01523782 Completed Phase 2 Administration of GRASPA (Suspension of Erythrocytes Encapsulating L-asparaginase) in Elderly Patients With First Line Acute Lymphoblastic Leukemia April 2009 October 2012
NCT01523977 Completed Phase 1 Everolimus With Multiagent Re-Induction Chemotherapy in Pediatric Patients With ALL November 2011 November 2018
NCT01540812 Completed Treatment of Acute Lymphoblastic Leukemia HIGH RISK BCR / ABL NEGATIVE IN ADULTS February 2012 December 1, 2019
NCT01556386 Completed Pharmacogenetic Analysis of Korean Pediatric Patients With Acute Lymphoblastic Leukemia June 2006 May 2012
NCT01564784 Completed Phase 3 A Study Of Inotuzumab Ozogamicin Versus Investigator's Choice Of Chemotherapy In Patients With Relapsed Or Refractory Acute Lymphoblastic Leukemia August 2, 2012 January 4, 2017
NCT01565447 Completed Acute Lymphoblastic Leukemia (ALL) and Lymphoblastic Lymphoma Gait Parameters Study December 2011 March 20, 2023
NCT01611298 Completed N/A Donor-Derived Humoral Immunity, Hematopoietic Stem Cell Transplantation, TAR March 2008 July 2013
NCT01641107 Completed Phase 2 Phase II Front-line Ponatinib in Adult Philadelphia+/BCR-ABL+ Acute Lymphoblastic Leukemia. December 4, 2014 September 30, 2021
NCT01643408 Completed Phase 2 A Study of Erwinaze Administered Intravenously in Patients Who Had an Allergy to Frontline Asparaginase Therapy November 2012 December 2013
NCT01643668 Completed Phase 2 Busulfan/Clofarabine + Allogeneic Stem Cell Transplantation July 2012 August 2016
NCT01663129 Completed Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence Study January 2005 March 6, 2014
NCT03267186 Completed Phase 2 Ibrutinib in Preventing Acute Leukemia in Patients After Reduced-Intensity Conditioning and Stem Cell Transplant September 12, 2017 April 30, 2021
NCT01678508 Completed Pharmacogenetically Based Dosing of Thiopurines in Childhood Acute Lymphoblastic Leukemia January 2002 February 2012
NCT01684150 Completed Phase 1 A Phase 1, Open-Label, Dose-Escalation & Expanded Cohort, Continuous IV Infusion, Multi-center Study of the Safety, Tolerability,PK & PD of EPZ-5676 in Treatment Relapsed/Refractory Patients With Leukemias Involving September 2012 February 2016
NCT03267030 Completed Phase 2 Asparaginase Encapsulated in Erythrocytes for Patients With ALL and Hypersensitivity to PEG-asparaginase August 23, 2017 October 22, 2020
NCT03190499 Completed Quality of Life in Children With Cancer August 1, 2017 August 1, 2018
NCT01696461 Completed Phase 2 A Phase II Study Evaluating the Safety and Efficacy of Subcutaneous Plerixafor May 2013 August 2016
NCT01697020 Completed Phase 1 Bioequivalence of An Oral Mercaptopurine Suspension 100 Mg / 5 Ml Versus Tablet in Healthy Male Subjects Under Fasting Conditions September 2012 November 2012
NCT01713582 Completed Phase 1 A Dose-finding Study of the Bromodomain (Brd) Inhibitor OTX015/ Birabresib (MK-8628) in Hematologic Malignancies (MK-8628-001) December 14, 2012 January 20, 2017
NCT01756118 Completed Phase 1 A Phase I, Dose-finding Study of BEZ235 in Adult Patients With Relapsed or Refractory Acute Leukemia June 2012 February 7, 2020
NCT01766804 Completed N/A Effect of Bovine Colostrum on Toxicity and Inflammatory Responses March 2013 December 2016
NCT01794299 Completed Phase 2 Safety and Efficacy of Donor T-lymphocytes Depleted ex Vivo of Host Alloreactive T-cells (ATIR) in Patients With a Hematologic Malignancy Who Received a Hematopoietic Stem Cell Transplantation From a Haploidentical Donor March 2013 September 2017
NCT01795378 Completed Phase 1/Phase 2 Safety and Efficacy Study of Donor Natural Killer Cells Given After Haploidentical Hematopoietic Cell Transplantation February 2013 May 2015
NCT01810120 Completed Phase 1/Phase 2 Trial to Assess the Efficacy of a TCR Alfa Beta Depleted Graft in Pediatric Affected by ALL or AML and Receiving an HSCT January 2012 December 2016
NCT01842672 Completed Phase 1/Phase 2 Mitoxantrone and Clofarabine for Treatment of Recurrent NHL or Acute Leukemia March 2013 September 2022
NCT01854567 Completed Phase 3 P3 Study of Umbilical Cord Blood Cells Expanded With MPCs for Transplantation in Patients With Hematologic Malignancies August 2013 May 5, 2017
NCT03187977 Completed N/A Cognitive Intervention at the End of Therapy for Survivors of Childhood ALL Treated on TOTXVI August 3, 2017 October 13, 2021
NCT01886651 Completed The Influence of Thiopurine Methyltransferase Activity on Toxicity After High-dose Methotrexate in Childhood Acute Lymphoblastic Leukemia July 2011 February 2012
NCT01943682 Completed Phase 1 Safety Study of CPX-351 in Children With Relapsed Leukemia or Lymphoma September 2013 April 2019
NCT01951885 Completed Phase 3 Tac, Mini-MTX, MMF Versus Tac, MTX for GVHD Prevention July 7, 2014 August 11, 2021
NCT02003612 Completed Historical Data Analysis of Hematological Remission and Survival in Adults With R/R Acute Lymphoblastic Leukemia October 1, 2013 April 28, 2014
NCT03147365 Completed N/A Effect of Different Exercises on Quality of Life of Leukemia Patients. March 5, 2017 April 5, 2020
NCT02010931 Completed Retrospective Analysis of Survival in Adult MRD Positive Acute Lymphoblastic Leukemia Patients September 2013 June 2014
NCT02042690 Completed Phase 3 Haplo-identical HSCT Versus Chemotherapy for Adult Acute Lymphoblastic Leukemia Patients July 2014 April 2019
NCT03123939 Completed Phase 3 Phase III B in Acute Lymphoblastic Leukemia April 24, 2017 October 13, 2020
NCT03118128 Completed N/A Metformin Reduce the Relapse Rate on Patients With B-cell Precursor (Ph+ Negative) Acute Lymphoblastic Leukemia January 1, 2015 April 30, 2017
NCT02086773 Completed Phase 1 Red Cell Transfusion Goals in Patients With Acute Leukemias April 2014 September 2015
NCT02099266 Completed N/A Use of Hyperbaric Oxygen Therapy to Improve Umbilical Cord Blood Stem Cell Homing and Subsequent Engraftment June 2013 February 2016
NCT02118324 Completed N/A Exergaming Intervention in ALL Patients March 2014 January 2016
NCT02181478 Completed Early Phase 1 Intra-Osseous Co-Transplant of UCB and hMSC July 22, 2015 February 7, 2020
NCT02185781 Completed Phase 1 Phase I Study of Adoptive Immunotherapy With Enriched and Expanded Autologous Natural Killer (NK) Cells for Patients With Ph+ Acute Lymphoblastic Leukemia (ALL) January 28, 2015 November 29, 2021
NCT02188290 Completed Transplant-Related Mortality in Patients Undergoing a Peripheral Blood Stem Cell Transplantation or an Umbilical Cord Blood Transplantation September 2014 June 2015
NCT03096782 Completed Phase 2 Umbilical Cord Blood Transplant With Added Sugar and Chemotherapy and Radiation Therapy in Treating Patients With Leukemia or Lymphoma October 13, 2017 September 20, 2022
NCT02228772 Completed Phase 1 Phase I Study of MLN 9708 in Addition to Chemotherapy for the Treatment of Acute Lymphoblastic Leukemia in Older Adults December 2014 November 2019
NCT03023046 Completed Phase 2 Etoposide, Prednisone, Vincristine Sulfate, Cyclophosphamide, and Doxorubicin in Treating Patients With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma February 23, 2017 May 1, 2022
NCT03005392 Completed Phase 1/Phase 2 Home-exercise Program for Children and Adolescent Survivors of Acute Lymphoblastic Leukemia June 2015 March 2016
NCT02272673 Completed The Effects of Honey on Febrile Neutropenia in Children With Acute Lymphoblastic Leukemia March 2011 September 2014
NCT02295839 Completed N/A Sleep Hygiene and Relaxation Intervention to Improve Sleep and Fatigue for Children Receiving Maintenance Chemotherapy May 2011 August 2014
NCT02960646 Completed Phase 1 Engineered Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies January 18, 2017 February 13, 2023
NCT02912676 Completed Phase 1/Phase 2 Thiopurine EnhAnced Maintenance Therapy October 2016 April 2020
NCT02336282 Completed N/A Treatment for Executive Dysfunction in Adult Survivors of Childhood Acute Lymphoblastic Leukemia January 12, 2015 July 20, 2017
NCT02890758 Completed Phase 1 Phase I Trial of Universal Donor NK Cell Therapy in Combination With ALT803 May 22, 2018 February 17, 2023
NCT02340884 Completed Phase 2 A Pilot RCT of the PRISM Intervention for AYAs With Cancer January 30, 2015 December 19, 2021
NCT02369653 Completed Phase 3 A Study of the Safety and Effectiveness of Apixaban in Preventing Blood Clots in Children With Leukemia Who Have a Central Venous Catheter and Are Treated With Asparaginase October 22, 2015 July 7, 2021
NCT02373579 Completed Phase 2 Effect of Omega-3 Fatty Acids on Methotrexate Induced Hepatotoxicity in Children With Acute Lymphoblastic Leukemia June 2012 October 2014
NCT02447718 Completed Phase 4 Vaccinating Children After Chemotherapy November 16, 2015 March 5, 2018
NCT02862652 Completed N/A Role of the Microparticles and of Tissue Factor in the Pro-thrombotic Phenotype and the Thromboembolic Complications During the Acute Lymphoblastic Leukemia in Children. May 2014 March 21, 2017
NCT02500550 Completed Phase 2 Safety and Efficacy of Two Doses of ATIR101, a T-lymphocyte Enriched Leukocyte Preparation Depleted of Host Alloreactive T-cells, in Patients With a Hematologic Malignancy Who Received a Hematopoietic Stem Cell Transplantation From a Haploidentical Donor October 9, 2015 December 17, 2018
NCT02847130 Completed Identifying, Understanding, and Overcoming Barriers to the Use of Clinical Practice Guidelines in Pediatric Oncology November 21, 2016 June 30, 2023
NCT02813252 Completed Long-Term Follow-up Study for Patients Previously Treated With JCAR015 August 30, 2016 October 22, 2021
NCT02529813 Completed Phase 1 CD19-Specific T-cells in Treating Patients With Advanced Lymphoid Malignancies December 16, 2015 November 8, 2021
NCT02807883 Completed Phase 2 Blinatumomab Maintenance Following Allogeneic Hematopoietic Cell Transplantation for Patients With Acute Lymphoblastic Leukemia August 2016 February 1, 2022
NCT02779283 Completed Phase 1 Personalized Kinase Inhibitor Therapy Combined With Chemotherapy in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia January 13, 2016 September 20, 2018
NCT02544438 Completed Phase 1/Phase 2 Study Evaluating the Safety and Efficacy of Astarabine in Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia September 2015 September 20, 2017
NCT02544789 Completed Phase 2 Clofarabine in Chinese Pediatric Patients With Refractory or Relapsed Acute Lymphoblastic Leukemia June 2009 May 2012
NCT02566395 Completed Phase 3 Stem Cell Transplantation From HLA Partially-Matched Related Donors for Patients With Hematologic Malignancies December 2014 February 14, 2022
NCT00003838 Completed Phase 2 Specialized Blood Cell Transplants for Cancers of the Blood and Bone Marrow April 15, 1999 June 18, 2020
NCT02743351 Completed Phase 1/Phase 2 Study of ProTmune for Allogeneic HCT in Adult Patients With Hematologic Malignancies December 20, 2016 November 5, 2021
NCT02639559 Completed Phase 2 Safety and Efficacy of BL-8040 for the Mobilization of Donor Hematopoietic Stem Cells and Allogeneic Transplantation in Patients With Advanced Hematological Malignancies March 31, 2016 April 7, 2023
NCT00015587 Completed Molecular Epidemiology of Childhood Leukemia (Aka The California Childhood Leukemia Study) April 1995 July 2016
NCT00026780 Completed Eligibility Screening for a NCI Pediatric Oncology Branch Research Study September 24, 2001 October 7, 2020
NCT00075725 Completed Phase 3 Dexamethasone Compared With Prednisone During Induction Therapy and Methotrexate With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia December 29, 2003 March 31, 2021
NCT00096161 Completed Phase 2 Pentostatin and Lymphocyte Infusion in Preventing Graft Rejection in Patients Who Have Undergone Donor Stem Cell Transplant May 2003 August 2015
NCT00103285 Completed Phase 3 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia April 11, 2005 March 31, 2021
NCT00130195 Completed Phase 2 Study of Imatinib-Combined Chemotherapy for BCR-ABL-Positive Acute Lymphoblastic Leukemia (ALL) September 2002 May 2008
NCT00143559 Completed Phase 2 Stem Cell Transplantation as Immunotherapy for Hematologic Malignancies August 2005 January 2009
NCT00144677 Completed Phase 2 Sirolimus With Tacrolimus for Graft-vs-Host Disease Prophylaxis After Un-Related Stem Cell Transplantation November 2003 June 2006
NCT00144703 Completed Phase 2 Sirolimus With Tacrolimus for Graft-vs-Host Disease Prophylaxis After Related Stem Cell Transplantation July 2002 November 2006
NCT00144963 Completed Phase 1/Phase 2 Liposomal Vincristine Plus Dexamethasone in Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia July 2002 August 2006
NCT06338020 Completed N/A Adaptive Variable-Resistance Training in Pediatric Survivors of Acute Lymphoblastic Leukemia December 29, 2022 January 4, 2024
NCT00165178 Completed Phase 3 Treatment of Acute Lymphoblastic Leukemia in Children September 2000 May 2011
NCT00171249 Completed Phase 2 An Extension Study to Determine the Safety and Anti-Leukemic Effects of Imatinib Mesylate in Adult Participants With Ph+ Leukemia August 9, 1999 September 23, 2013
NCT00184041 Completed Phase 2 Intensified Post Remission Therapy Containing PEG-Asparaginase July 2004 December 2012
NCT00186875 Completed Phase 2 Therapy for Pediatric Relapsed or Refractory Acute Lymphoblastic Leukemia November 2003 August 2016
NCT06195735 Completed Forecasting Hypersensitivity Against PEG-asparaginase to Optimize Outcome in ALL July 17, 2020 December 21, 2023
NCT00187083 Completed Phase 3 A Study of Children With Refractory or Relapsed ALL February 1997 December 2003
NCT00222027 Completed Phase 2 Feasibility of Risk-Adapted Therapy in Young Adult Acute Lymphoblastic Leukemia: a Multicenter Trial November 2003 December 2008
NCT00270881 Completed Phase 1/Phase 2 Safety and Efficacy of Unrelated Cord Blood Transplantation for Adult Patients With Hematologic Malignancies January 2006 January 2011
NCT00285259 Completed Phase 2 Cytomegalovirus (CMV) Vaccine in Donors and Recipients Undergoing Allogeneic Hematopoietic Cell Transplant (HCT) January 31, 2006 November 30, 2010
NCT00287105 Completed Phase 2 Safety and Efficacy of Imatinib Added to Chemotherapy in Treatment of Ph+ Acute Lymphoblastic Leukemia in Children December 2005 March 3, 2017
NCT00300664 Completed Phase 2/Phase 3 A Randomized Trial of Human Growth Hormone (hGH) vs Placebo in Intensively Treated Haemato-Oncology Patients. July 2002 April 2005
NCT00315705 Completed Phase 1/Phase 2 A Study of Clofarabine in Combination With Etoposide and Cyclophosphamide in Children With Acute Leukemias. March 2006 May 2010
NCT05679817 Completed N/A How Effective is the Dose-graded Aerobic Training in Children Survivors of Acute Lymphoblastic Leukemia? October 3, 2021 November 24, 2022
NCT05563545 Completed Phase 1 Anti-CD19 CAR-Engineered NK Cells in the Treatment of Relapsed/Refractory Acute Lymphoblastic Leukemia July 21, 2022 November 25, 2022
NCT00358072 Completed Phase 2 Treatment of Adult ALL With an MRD-directed Programme. May 2000 September 2008
NCT00368355 Completed Phase 2 T Cell Depletion for Recipients of HLA Haploidentical Related Donor Stem Cell Grafts April 2000 November 2016
NCT00374933 Completed Phase 1 Enhancing Graft vs Leukemia Via Delayed Ex-Vivo Co-Stimulated DLI After Non-Myeloablative Stem Cell Transplantation April 2007 December 2009
NCT00376467 Completed Phase 2 STI 571 (GLIVEC) in the Treatment of Adult Acute Lymphoblastic Leukemia December 2001 February 2011
NCT00378534 Completed Phase 2 Methods to Enhance the Safety and Effectiveness of Stem Cell Transplants September 2006 April 2014
NCT00388193 Completed Phase 2 Rituximab Combined With Chemotherapy in Burkitt's Lymphoma August 2006 December 2013
NCT00388895 Completed Phase 2 Glivec in Ph Positive Lymphoblastic Leukemia June 2002 October 2007
NCT00390793 Completed Phase 2 Combination Chemotherapy and Dasatinib in Treating Participants With Philadelphia Positive or BCR-ABL Positive Acute Lymphoblastic Leukemia. September 28, 2006 February 2, 2024
NCT00411541 Completed Phase 4 Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia April 1995 January 2004
NCT00412243 Completed Phase 1/Phase 2 Clofarabine and Cyclophosphamide Combination in Acute Lymphoblastic Leukemia Patients March 2006 April 2012
NCT00435864 Completed N/A Natural Killer Index From Hematopoietic Stem Cell Graft April 2007 November 2013
NCT05433532 Completed Phase 2 Study of Azacitidine,Venetoclax,and Flumatinib in Newly Diagnosed Ph-positive Acute Leukemia and CML-AP/BP Patients May 1, 2022 April 13, 2024
NCT00440726 Completed Phase 1/Phase 2 Bortezomib With Chemotherapy for Relapsed Pediatric Acute Lymphoblastic Leukemia (ALL) August 4, 2006 February 26, 2011
NCT00460694 Completed Phase 1/Phase 2 Allogeneic Cytokine-induced Killer Immunotherapy for Relapse After Allogeneic Marrow Transplant for Haematological Malignancies August 2006 December 2012
NCT00466895 Completed Phase 1 Lenalidomide in Acute Leukemias and Chronic Lymphocytic Leukemia. April 2007 July 2016
NCT00494897 Completed Phase 4 PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia June 1996 December 2007
NCT00505141 Completed Urban Environmental Exposures and Childhood Cancer September 2004 February 2006
NCT00513175 Completed Non-Myeloablative Allogeneic Stem Cell Transplantation With Matched Unrelated Donors for Treatment of Hematologic Malignancies, Renal Cell Carcinoma, and Aplastic Anemia October 2001 November 2007
NCT04956666 Completed Phase 2 A Roll-over Study to Provide Continued Treatment With Lyophilized Pegaspargase (S95014) in Pediatric Patients With Acute Lymphoblastic Leukemia (ALL) June 15, 2021 January 23, 2023
NCT04954326 Completed Phase 2 A Study Comparing the Blood Levels of Both Pegaspargase (S95014) Formulations (Liquid vs Lyophilized) in the Treatment of Paediatric Patients With Acute Lymphoblastic Leukemia (ALL) May 7, 2021 May 20, 2022
NCT00526175 Completed Phase 4 LAL-BR/2001: Study Treatment to Low Risk ALL June 2001 December 2015
NCT00526305 Completed Phase 4 LAL-Ph-2000: Treatment of Acute Lymphoblastic Leukemia Chromosome Philadelphia Positive January 2000 April 2005
NCT00526409 Completed Phase 4 LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia June 2005 October 2014
NCT00529360 Completed Phase 1/Phase 2 Allogeneic Stem Cell Transplant With Clofarabine, Ara-C and TBI for AML and ALL June 2007 March 2016
NCT00539695 Completed Phase 2 Low Dose IL-2, Hematopoietic Stem Cell Transplantation, IL2 for GVHD June 2007 March 2014
NCT00549848 Completed Phase 3 Total Therapy Study XVI for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia October 29, 2007 March 26, 2022
NCT02646839 Enrolling by invitation Phase 2 KIR Favorable Mismatched Haplo Transplant and KIR Polymorphism in ALL/AML/MDS Allo-HCT Children October 2015 August 2024
NCT00923442 Enrolling by invitation Biology Studies of Hematologic Cancers February 24, 2004
NCT03226704 Enrolling by invitation Leukapheresis for CAR or Adoptive Cell Therapy Manufacturing August 14, 2017 July 31, 2030
NCT02197650 No longer available Expanded Access Program: Safety of Erythrocytes Encapsulating L-asparaginase (GRASPA®) in Combination With Polychemotherapy in Patients Under 55 Years Old With Acute Lymphoblastic Leukemia (ALL) at Risk to Receive Other Formulation of Asparaginase
NCT01200017 No longer available Expanded Access Protocol (EAP) Using the CliniMACS® Device for Pediatric Haplocompatible Donor Stem Cell Transplant
NCT03594162 No longer available Compassionate Use of CAR T Cells Targeting the CD19 Antigen and Containing the Inducible Caspase 9 Safety Switch
NCT05054465 Not yet recruiting Phase 1/Phase 2 A Phase 1b-2 Trial to Assess Venetoclax and Navitoclax Consolidation and Post-transplant Maintenance in High-risk Patients With T-ALL October 1, 2021 August 1, 2026
NCT06323044 Not yet recruiting N/A MedSupport Intervention to Identify and Address Barriers to Pediatric Medication Adherence June 15, 2024 June 15, 2029
NCT06242353 Not yet recruiting Coagulopathy in Childhood Acute Lymphoblastic Leukaemia March 1, 2024 November 2028
NCT06128070 Not yet recruiting Phase 2 Ruxolitinib With Tacrolimus and Methotrexate for the Prevention of Graft Versus Host Disease in Pediatric and Young Adult Patients Undergoing Allogeneic Hematopoietic Cell Transplant for Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome June 14, 2024 October 31, 2027
NCT03932903 Not yet recruiting N/A Mobile Health Intervention to Support Oral Chemotherapy Adherence in Adolescents and Young Adults With Leukemia March 1, 2024 August 31, 2024
NCT06160115 Not yet recruiting The Role of NK Cells to Detect Blood Infection in ALL. February 1, 2024 April 1, 2025
NCT06308588 Not yet recruiting Phase 2 Phase II Study of the Combination of Blinatumomab and Asciminib in Patients With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia September 30, 2024 May 2029
NCT06289673 Not yet recruiting Phase 4 Identification of Necessary Information for Treatment Induction in Newly Diagnosed Acute Lymphoblastic Leukemia/Lymphoma July 2024 May 2039
NCT06452732 Not yet recruiting Using Multiparametric Flow Cytometry to Detect Peripheral Blood and Bone Marrow Leukaemia Stem Cells for Relapse Prediction in P-AML June 15, 2024 June 30, 2026
NCT05968170 Not yet recruiting N/A TCRαβ/CD19 Depletion of Stem Cell Grafts for Transplant December 1, 2023 July 1, 2035
NCT06350994 Not yet recruiting Early Assessment of Cardiac Function After Treatment With CAR-T Cells September 2024 January 2027
NCT05521087 Not yet recruiting Phase 1 A Study of JNJ-75276617 in Combination With Conventional Chemotherapy for Pediatric and Young Adult Participants With Relapsed/Refractory Acute Leukemias December 26, 2025 January 29, 2030
NCT05025774 Not yet recruiting Fitness and Lung Function Among Survivors of Heart Transplant, Leukemia and Infant BPD Through Exercise September 1, 2024 August 1, 2025
NCT05381181 Not yet recruiting Phase 1 Safety and Efficacy Evaluation of Next-generation CD19-UCART December 20, 2023 May 3, 2026
NCT05223686 Not yet recruiting Phase 1 To Evaluate the Safety and Tolerability of Human CD19-CD22 Targeted T Cells Injection for Subjects With R/R B-ALL. February 10, 2022 March 10, 2025
NCT06291428 Not yet recruiting Raman Spectroscopy Compared to Flow Cytometry October 15, 2024 December 30, 2026
NCT06287944 Not yet recruiting Phase 1 225Ac-DOTA-Anti-CD38 Daratumumab Monoclonal Antibody With Fludarabine, Melphalan and Total Marrow and Lymphoid Irradiation as Conditioning Treatment for Donor Stem Cell Transplant in Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Myelodysplastic Syndrome June 18, 2024 February 24, 2027
NCT04092348 Not yet recruiting FoxO3a and PU.1 in Acute Lymphoblastic Leukemia August 1, 2023 December 30, 2024
NCT06087419 Not yet recruiting Phase 1/Phase 2 A Prospective Clinical Study of Bridging alloHSCT After Treatment With Obinutuzumab in Combination With Chidamide and Venetoclax in RR Ph-ALL and B-cell Lymphoma Patients October 30, 2023 December 30, 2025
NCT05751044 Not yet recruiting Phase 1/Phase 2 HEM-iSMART-B: Dasatinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies October 1, 2023 October 1, 2030
NCT06461091 Not yet recruiting the Efficacy and Safety of Total Myeloid Irradiation (TMI) in the Treatment of Adult Acute Lymphoblastic Leukemia June 2024 April 30, 2025
NCT06446661 Not yet recruiting N/A Using Text Messages to Improve Oral Chemotherapy for Adolescents and Young Adults With Acute Lymphoblastic Leukemia June 15, 2024 June 15, 2028
NCT04888741 Recruiting Phase 2 Methods of T Cell Depletion Trial (MoTD) February 22, 2021 January 2026
NCT04904588 Recruiting Phase 2 HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide September 30, 2021 July 2024
NCT06367725 Recruiting Pharmacokinetics of Dexamethasone in Childhood ALL and Reduction in Bone Mineral Density April 11, 2024 December 30, 2030
NCT03286634 Recruiting Phase 2 ASIA Down Syndrome Acute Lymphoblastic Leukemia 2016 April 18, 2017 March 31, 2033
NCT05442515 Recruiting Phase 1/Phase 2 CD19/CD22 Bicistronic Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory CD19/CD22-expressing B Cell Malignancies December 28, 2022 July 1, 2029
NCT04975555 Recruiting Phase 2 Study to Evaluate the Role of Siltuximab in Treatment of Cytokine Release Syndrome (CRS) and Immune Effector Cell Associated Neurotoxicity (ICANS) Related to CAR-T Cell Therapy November 15, 2021 December 31, 2025
NCT05014165 Recruiting Backtracking Leukemia-Typical Somatic Mutations in Cord Blood August 25, 2021 September 30, 2026
NCT05031897 Recruiting Phase 2 Reduced-Intensity Conditioning for the Prevention of Treatment-Related Mortality in Patients Who Undergo a Hematopoietic Stem Cell Transplant October 25, 2021 October 1, 2024
NCT05428176 Recruiting N/A A High Intensity Electronic Health Intervention for the Reduction of Learning Disparities in Childhood Cancer Survivors February 16, 2023 June 30, 2027
NCT05400122 Recruiting Phase 1 Natural Killer (NK) Cells in Combination With Interleukin-2 (IL-2) and Transforming Growth Factor Beta (TGFbeta) Receptor I Inhibitor Vactosertib in Cancer September 9, 2022 June 1, 2026
NCT05139004 Recruiting Phase 1 90Y-DOTA-anti-CD25 Basiliximab, Fludarabine, Melphalan, and Total Marrow and Lymphoid Irradiation for the Treatment of High-Risk Acute Leukemia or Myelodysplastic Syndrome July 19, 2022 December 13, 2024
NCT05153330 Recruiting Phase 1 Study of BMF-219, a Covalent Menin Inhibitor, in Adult Patients With AML, ALL (With KMT2A/ MLL1r, NPM1 Mutations), DLBCL, MM, and CLL/SLL January 24, 2022 March 31, 2025
NCT05252403 Recruiting Phase 2 Residual Disease Driven Strategy for CARCIK (CD19) in Adults/Pediatric BCP-ALL December 1, 2021 March 2025
NCT05268003 Recruiting Phase 2 A Phase II Study of the Combination of Ponatinib With Mini-hyper CVD Chemotherapy and Venetoclax in Patients With Relapsed or Refractory T-cell Acute Lymphoblastic Leukemia June 7, 2022 October 5, 2026
NCT05375617 Recruiting European Prospective Investigation Into Childhood Cancer July 7, 2023 March 1, 2031
NCT06144606 Recruiting Phase 2 Study of KTE-X19 in Minimal Residual Disease (MRD) Positive B-Cell Acute Lymphoblastic Leukemia (B-ALL) December 26, 2023 November 15, 2028
NCT05326919 Recruiting The Patient Cohort of the National Center for Precision Medicine in Leukemia March 28, 2022 March 2042
NCT05364762 Recruiting Phase 2 Adding Itacitinib to Cyclophosphamide and Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Hematopoietic Stem Cell Transplants November 23, 2022 April 28, 2024
NCT05327894 Recruiting Phase 3 Interfant-21 Treatment Protocol for Infants Under 1 Year With KMT2A-rearranged ALL or Mixed Phenotype Acute Leukemia December 15, 2022 September 2030
NCT05334069 Recruiting Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection August 1, 2022 February 2025
NCT05334823 Recruiting Phase 2 A Study of pCAR-19B in the Treatment of CD19-positive Relapsed/Refractory B-ALL in Children and Adolescents January 26, 2022 July 1, 2025
NCT02300961 Recruiting N/A Feasibility Neurocognitive Outcome After Transplant December 1, 2014 September 2026
NCT03314974 Recruiting Phase 2 Myeloablative Allo HSCT With Related or Unrelated Donor for Heme Disorders March 30, 2018 November 10, 2025
NCT03318770 Recruiting Post-Frontline Sequential Treatment of Adult Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia May 10, 2019 May 2024
NCT06125106 Recruiting Phase 1 Prospective, Single-arm, Multicenter Clinical Study on Haploidentical Hematopoietic Stem Cell Transplantation in Patients With MRD Positive CD19+ALL Treated With Conditioning Regimens Containing Blinatumomab November 16, 2023 February 1, 2026
NCT06093334 Recruiting N/A Imaging of Chemotherapy-induced Morphological and Functional Lung Changes in Childhood ALL and HD October 17, 2023 December 2024
NCT03399773 Recruiting Phase 2 Infusion of Expanded Cord Blood Cells in Addition to Single Cord Blood Transplant in Treating Patients With Acute Leukemia, Chronic Myeloid Leukemia, or Myelodysplastic Syndromes May 10, 2022 June 30, 2026
NCT03422731 Recruiting Early Phase 1 Multi-modality Imaging and Collection of Biospecimen Samples in Understanding Bone Marrow Changes in Patients With Acute Myeloid Leukemia Undergoing TBI and Chemotherapy February 15, 2018 November 6, 2024
NCT02716233 Recruiting Phase 3 A French Protocol for the Treatment of Acute Lymphoblastic Leukemia (ALL) in Children and Adolescents April 2016 April 2026
NCT03441061 Recruiting Phase 2 Inotuzumab Ozogamicin in Treating Patients With B-cell Acute Lymphocytic Leukemia With Positive Minimal Residual Disease February 15, 2018 February 28, 2025
NCT03448393 Recruiting Phase 1 CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory CD19/CD22-expressing B Cell Malignancies March 26, 2018 December 31, 2040
NCT06059391 Recruiting Phase 2 CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant August 30, 2024 January 1, 2028
NCT03494569 Recruiting Phase 1 Total Marrow and Lymphoid Irradiation, Fludarabine, and Melphalan Before Donor Stem Cell Transplant in Treating Participants With High-Risk Acute Leukemia or Myelodysplastic Syndrome July 6, 2018 November 11, 2028
NCT03533816 Recruiting Phase 1 Expanded/Activated Gamma Delta T-cell Infusion Following Hematopoietic Stem Cell Transplantation and Post-transplant Cyclophosphamide January 31, 2020 January 2025
NCT06025682 Recruiting Retrospective Observational Study on Infective Complications and Outcome of Patients With ALL Treated With INO April 4, 2024 January 2025
NCT03564678 Recruiting Phase 2 Levocarnitine and Vitamin B Complex in Treating PEG-Asparaginase or Inotuzumab Ozogamicin-Induced Hyperbilirubinemia in Patients With Acute Lymphoblastic Leukemia May 17, 2018 December 31, 2036
NCT03568266 Recruiting Pharmacogenomics of Asparaginase Induced Hepatotoxicity May 22, 2018 May 22, 2026
NCT03571321 Recruiting Phase 1 Ruxolitinib and Chemotherapy in Adolescents and Young Adults With Ph-like Acute Lymphoblastic Leukemia May 28, 2019 September 5, 2027
NCT06013423 Recruiting Phase 2 Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With High-Risk Hematologic Diseases July 6, 2024 October 31, 2025
NCT02727803 Recruiting Phase 2 Personalized NK Cell Therapy in CBT May 19, 2016 May 31, 2025
NCT03622788 Recruiting Phase 1/Phase 2 Cytokine-Treated Veto Cells in Treating Patients With Hematologic Malignancies Following Stem Cell Transplant August 8, 2019 December 1, 2025
NCT06001385 Recruiting Phase 2 HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation With Reduced Dose Post Transplantation Cyclophosphamide GvHD Prophylaxis December 8, 2023 June 30, 2026
NCT05969002 Recruiting Pilot Prospective Study for PET-CT Imaging in Participants With Relapsed/Refractory Acute Leukemias August 25, 2023 April 30, 2026
NCT03007147 Recruiting Phase 3 Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia August 8, 2017 September 30, 2027
NCT03016377 Recruiting Phase 1/Phase 2 Administration of Autologous CAR-T CD19 Antigen With Inducible Safety Switch in Patients With Relapsed/Refractory ALL March 22, 2012 April 22, 2041
NCT02670564 Recruiting Phase 4 ALL SCTped FORUM - Pharmacogenomic Study (add-on Study) April 2013 April 2026
NCT03765177 Recruiting Phase 1/Phase 2 CLIC-1901 for the Treatment of Patients With Relapsed/Refractory CD19 Positive Hematologic Malignancies October 16, 2019 October 31, 2037
NCT03779854 Recruiting Phase 2 Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant August 29, 2019 December 31, 2025
NCT05963971 Recruiting N/A A Bilingual Virtually-based Intervention (PEDALL) for the Prevention of Weight Gain in Childhood ALL Patients Considering Key Genetic and Sociodemographic Risk Factors June 23, 2023 June 23, 2027
NCT03802695 Recruiting Phase 1 A Phase 1 Study of Orca-Q in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies April 8, 2019 April 2028
NCT06299462 Recruiting Phase 1/Phase 2 PTCy and ATG for MSD and MUD Transplants June 20, 2024 June 1, 2031
NCT03810196 Recruiting N/A CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post TCRαβ/CD19 Depleted HSCT March 1, 2019 January 2026
NCT03856216 Recruiting Phase 2 Inotuzumab Ozogamicin and Chemotherapy in Treating Patients With Leukemia or Lymphoma Undergoing Stem Cell Transplantation October 28, 2019 March 31, 2025
NCT06408194 Recruiting Phase 1 Autologous CD22 CAR T Cells Following Commercial CD19 CAR T Cells in B Cell Malignancies May 13, 2024 June 2025
NCT05950204 Recruiting N/A Effect of Supplementation With ω-3 Fatty Acids, Vitamin D and Calcium in Patients With Acute Lymphoblastic Leukemia. September 10, 2022 December 31, 2024
NCT05929976 Recruiting InterNatIonal CHildhood Leukemia Microbiome/MEtabolome Cohort October 26, 2022 October 1, 2029
NCT05918692 Recruiting Phase 1 A Phase 1, Study of BMF-500 in Adults With Acute Leukemia July 26, 2023 July 31, 2026
NCT02047578 Recruiting Phase 2 Targeted Busulfan, Fludarabine, Etoposide Conditioning Regimen for HSCT in Childhood and Adolescent ALL. February 5, 2014 December 2023
NCT03913559 Recruiting Phase 2 Inotuzumab Ozogamicin for Children With MRD Positive CD22+ Lymphoblastic Leukemia May 14, 2019 January 2025
NCT05887167 Recruiting Phase 1 Feasibility and Safety of Collecting and Combining Autologous Hematopoietic Stem Cells With Chimeric Antigen Receptor (CAR) T-Cell Therapy in Subjects With Relapsed/Refractory Hematological Malignancies March 2, 2024 December 15, 2026
NCT03934372 Recruiting Phase 1/Phase 2 Safety and Efficacy of Ponatinib for Treatment of Pediatric Recurrent or Refractory Leukemias, Lymphomas or Solid Tumors January 29, 2020 January 4, 2025
NCT03960840 Recruiting Phase 1/Phase 2 Phase I/II Study of Rapcabtagene Autoleucel in CLL, 3L+ DLBCL, ALL and 1L HR LBCL June 26, 2019 June 30, 2027
NCT03970096 Recruiting Phase 2 Graft Versus Host Disease-Reduction Strategies for Donor Blood Stem Cell Transplant Patients With Acute Leukemia or Myelodysplastic Syndrome (MDS) November 19, 2019 December 31, 2028
NCT05866887 Recruiting N/A Insomnia Prevention in Children With Acute Lymphoblastic Leukemia September 26, 2023 October 1, 2024
NCT05811845 Recruiting Mercaptopurine Therapeutic Drug Monitoring to Optimize the Maintenance Phase of Childhood ALL July 30, 2022 December 31, 2026
NCT05809167 Recruiting Phase 2 Venetoclax+Azacytidine+Modified BUCY Conditioning Regimen for Acute Lymphoblastic Leukemia Undergoing Allo-HSCT January 20, 2022 January 20, 2026
NCT05800210 Recruiting Phase 2 Alpha/Beta T Cell and CD19+ B Cell Depletion in Allogeneic Stem Cell Transplantation in Patients With Malignant Diseases May 3, 2024 May 2027
NCT05793463 Recruiting Anti-mullerian Hormone in Acute Lymphoblastic Leukemia February 15, 2018 March 15, 2024
NCT05772000 Recruiting Clinical Significance of Occult Central Nervous System Localization September 8, 2020 September 8, 2024
NCT04028479 Recruiting The Registry of Oncology Outcomes Associated With Testing and Treatment May 5, 2021 October 1, 2031
NCT04049383 Recruiting Phase 1 CAR-20/19-T Cells in Patients With Relapsed/Refractory B Cell ALL October 16, 2020 June 1, 2026
NCT04065399 Recruiting Phase 1/Phase 2 A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation November 5, 2019 December 2024
NCT02508038 Recruiting Phase 1 Alpha/Beta CD19+ Depleted Haploidentical Transplantation + Zometa for Pediatric Hematologic Malignancies and Solid Tumors February 12, 2016 December 2025
NCT06277011 Recruiting Early Phase 1 Safety and Efficacy of Metabolically Armed CD19 CAR-T Cells (Meta10-19) in the Treatment of Relapsed and/or Refractory CD19-positive B Cell Hematological Malignancies Clinical Research February 10, 2023 May 15, 2025
NCT04532268 Recruiting Early Phase 1 A Study of Humanized CD19 CAR-T Cells Therapy for Patients With Relapsed and/or Refractory B-cell ALL and B-cell NHL August 23, 2020 August 23, 2026
NCT04537871 Recruiting Cardiovascular Reserve Evaluation in Survivors of Transplant, CREST Study November 18, 2020 December 4, 2024
NCT05579132 Recruiting Phase 1/Phase 2 A Phase Ib/II Study of CN201 in Precursor B-cell Acute Lymphoblastic Leukemia September 30, 2022 July 31, 2025
NCT04606433 Recruiting Phase 1 Phase I Clinical Study of GNC-038 in Patients With Non-Hodgkin's Lymphoma or Acute Lymphoblastic Leukemia November 4, 2020 November 2024
NCT05578378 Recruiting Phase 2/Phase 3 Cladribine Combined With G-CSF and Cytarabine as a Salvage Treatment in R/R ALL January 1, 2022 December 31, 2024
NCT04635384 Recruiting Assessment of Chimerism and Relapse Post Bone Marrow/Hematopoietic Cell Transplant (HCT) Using AlloHeme Test June 30, 2021 December 31, 2024
NCT05541341 Recruiting Effectiveness and Safety of Tisagenlecleucel Therapy in Brazilian Patients With B-lymphocyte Malignancies November 24, 2023 December 16, 2038
NCT05535855 Recruiting Phase 1 UCD19 CAR T Therapy in Adults With B-ALL and MRD Positivity in CR1 January 24, 2024 July 2027
NCT04684563 Recruiting Phase 1 huCART19-IL18 in NHL/CLL Patients May 6, 2021 May 2036
NCT04689204 Recruiting Early Phase 1 A Study of CTA30X Cell Injection in Patients With Relapsed or Refractory CD19-positive B-line Hematological Malignancies December 29, 2020 May 31, 2027
NCT03263572 Recruiting Phase 2 Blinatumomab, Methotrexate, Cytarabine, and Ponatinib in Treating Patients With Philadelphia Chromosome-Positive, or BCR-ABL Positive, or Relapsed/Refractory, Acute Lymphoblastic Leukemia November 29, 2017 November 30, 2025
NCT04726241 Recruiting Phase 1/Phase 2 The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study April 18, 2022 December 31, 2026
NCT04732845 Recruiting Phase 1 Human AntiCD19 Chimeric Antigen Receptor T Cells for Relapsed or Refractory Lymphoid Malignancies April 26, 2021 December 1, 2024
NCT04747912 Recruiting Phase 2 Study of Chemotherapy-Free Induction Regimen for Ph+ Acute Lymphoblastic Leukemia With Inotuzumab Ozogamicin (InO) March 2, 2021 May 1, 2026
NCT04764513 Recruiting Phase 1/Phase 2 Safety and Efficiency of γδ T Cell Against Hematological Malignancies After Allo-HSCT September 12, 2021 April 2025
NCT04787263 Recruiting Phase 1/Phase 2 CD19-CAR_Lenti T Cells in Pediatric Patients Affected by Relapsed/Refractory CD19+ ALL and DLBCL or PML March 4, 2021 March 3, 2038
NCT04811560 Recruiting Phase 1/Phase 2 A Study of JNJ-75276617 in Participants With Acute Leukemia May 19, 2021 February 16, 2026
NCT05519579 Recruiting Phase 2 Intrathecal Chemoprophylaxis to Prevent Neurotoxicity Associated With Blinatumomab Therapy for Acute Lymphoblastic Leukemia June 30, 2023 August 1, 2025
NCT04817761 Recruiting Phase 2/Phase 3 SPARK-ALL: Calaspargase Pegol in Adults With ALL July 7, 2021 February 2027
NCT05501899 Recruiting Early Phase 1 Use of Levocarnitine to Reduce Asparaginase Hepatotoxicity in Patients With Acute Lymphoblastic Leukemia March 3, 2023 December 31, 2023
NCT06195891 Recruiting Phase 1 Orca-T Following Chemotherapy and Total Marrow and Lymphoid Irradiation for the Treatment of Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia or Myelodysplastic Syndrome September 28, 2024 June 21, 2027
NCT06392581 Recruiting Observational Study on Invasive Fungal Infection Incidence in Ph-neg Acute Lymphoblastic Leukemia Patients April 14, 2022 June 14, 2024
NCT05457556 Recruiting Phase 3 Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for Children, Adolescents, and Young Adults With Acute Leukemia or Myelodysplastic Syndrome March 15, 2023 December 1, 2027
NCT04872478 Recruiting Phase 1 Pharmacokinetic and Safety Study of MRX-2843 in Adolescents and Adults With Relapsed/Refractory AML, ALL, or MPAL April 1, 2022 December 31, 2024
NCT03275493 Recruiting Phase 1/Phase 2 CD19 CAR-T Cells With CRS Suppression Technology for r/r CD19+ Acute Lymphoblastic Leukemia July 1, 2017 December 31, 2025
NCT00898755 Recruiting Collecting and Storing Tissue From Young Patients With Cancer March 5, 2007
NCT05581030 Recruiting Phase 1 CalPeg for Newly Diagnosed Acute Lymphoblastic Leukemia (ALL) May 1, 2023 November 2027
NCT06209190 Recruiting N/A Safety and Feasibility of TMLI as Conditioning Regimen in Allogeneic Hematopoietic Stem-cell Transplantation September 1, 2023 August 31, 2024
NCT04532203 Recruiting Early Phase 1 A Study of CAR-T Cells Therapy for Patients With Relapsed and/or Refractory Central Nervous System Hematological Malignancies November 1, 2020 November 1, 2026
NCT04532281 Recruiting Early Phase 1 A Study of Murine CD19 CAR-T Therapy for Patients With Relapsed or Refractory CD19+ B-cell Hematological Malignancies November 1, 2020 November 1, 2026
NCT05763290 Recruiting Childhood Cancer Survivors' Affective Response to Exercise March 22, 2023 December 2024
NCT06227026 Recruiting Phase 1 Pilot Study of Anti-CD19 Chimeric Antigen Receptor T Cells (CAR-T Cells) for the Treatment of Relapsed/Refractory CD19+ Malignancies February 20, 2024 January 15, 2027
NCT05748171 Recruiting Phase 2 A Study to Learn More About the Study Medicine Called Inotuzumab Ozogamicin (InO) in Children (1 to <18 Years) With First Relapse ALL May 17, 2023 July 9, 2031
NCT05739227 Recruiting Early Phase 1 Safety and Efficacy of Allogenic CD19-CAR-NK Cells in Treatmenting r/r B-cell Hematologic Malignancies March 1, 2023 May 2025
NCT05735717 Recruiting Phase 2 MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies May 11, 2023 November 30, 2030
NCT04179929 Recruiting N/A Treatment of Breakpoint Cluster Region-Abelson (BCR-ABL) Negative ALL in Adults November 25, 2019 February 2027
NCT06220487 Recruiting Phase 2 A Single-arm, Open-label Study of Olverembatinib, CD3/CD19 Bispecific T-cell Engager, and Chidamide in Patients With Newly Diagnosed Ph+ALL February 1, 2024 January 1, 2028
NCT05694364 Recruiting Phase 1 Dose Escalation/Dose Expansion Study of PRGN-3007 UltraCAR-T Cells in Patients With Advanced Hematologic and Solid Tumor Malignancies January 25, 2023 January 2026
NCT04195633 Recruiting Phase 2 Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignancies January 25, 2021 December 31, 2026
NCT05657652 Recruiting N/A CAV Regimen for R/R Ph- B-ALL October 1, 2022 October 2024
NCT06393335 Recruiting Early Phase 1 Safety and Efficacy of Metabolically Armed CD19 CAR-T Cells (Meta10-19) in the Treatment of Relapsed and/or Refractory CD19-positive B Cell Hematological Malignancies Clinical Research May 15, 2024 March 15, 2026
NCT05639673 Recruiting Severe Toxicity Free Survival Following Childhood Acute Lymphoblastic Leukemia June 15, 2023 November 1, 2025
NCT04227015 Recruiting Early Phase 1 A Study of CTA101 UCAR-T Cell Injection in Patients With Relapsed or Refractory CD19+ B-line Hematological Malignancy January 8, 2020 May 31, 2027
NCT02872987 Recruiting GMALL Registry and Collection of Biomaterial: Prospective Data Collection Regarding Diagnosis, Treatment and Outcome of Adult Acute Lymphoblastic Leukemia (ALL) Patients and Related Diseases Associated With a Prospective Collection of Biomaterial February 2009 December 2030
NCT04262843 Recruiting Phase 2 Total Marrow and Lymphoid Irradiation as Conditioning Regimen Before Hematopoietic Cell Transplantation in Patients With Myelodysplastic Syndrome or Acute Leukemia February 7, 2020 August 4, 2025
NCT05621291 Recruiting N/A A Study to Evaluate Next-Generation Sequencing (NGS) Testing and Monitoring of B-cell Recovery to Guide Management Following Chimeric Antigen Receptor T-cell (CART) Induced Remission in Children and Young Adults With B Lineage Acute Lymphoblastic Leu... June 23, 2024 December 31, 2025
NCT04322084 Recruiting Continuous Ambulatory Monitoring to Predict Elevated Risk of Infection in Children With Lymphoblastic Leukemia Undergoing Induction Chemotherapy (CAMPER-ALL) June 2024 July 2025
NCT05618041 Recruiting N/A The Safety and Efficay Investigation of CAR-T Cell Therapy for Patients With Hematological Malignancies September 7, 2022 December 6, 2024
NCT03246906 Recruiting Phase 2 Comparison of Triple GVHD Prophylaxis Regimens for Nonmyeloablative or Reduced Intensity Conditioning Unrelated Mobilized Blood Cell Transplantation September 11, 2017 October 11, 2026
NCT04340167 Recruiting Phase 2 Study of Anti-CD22 CAR-T Cells Treating Leukemia Children May 1, 2020 October 1, 2024
NCT05589896 Recruiting Phase 1/Phase 2 A First-in-Human Study of HLA-Partially to Fully Matched Allogenic Cryopreserved Deceased Donor Bone Marrow Transplantation for Patients With Hematologic Malignancies March 30, 2024 August 2025
NCT05587582 Recruiting Behavioral Parenting Skills As A Novel Target for Improving Pediatric Medication Adherence September 1, 2022 November 30, 2026
NCT00991744 Suspended Phase 3 Liposomal Cytarabine for Central Nervous System (CNS)-Treatment in High-risk Acute Lymphoblastic Leukemia (ALL) January 2009 December 2018
NCT03128034 Suspended Phase 1/Phase 2 211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute Leukemia October 24, 2017 March 31, 2027
NCT04151706 Suspended Phase 2 CD34 Selected Allogeneic HCT w/ Myeloablative Conditioning Plus CD8+ Memory TCell Infusion in MDS, AL and CML February 27, 2020 February 2026
NCT03326921 Suspended Phase 1 HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplant February 23, 2018 July 16, 2028
NCT04928599 Suspended Financial Distress During Treatment for Pediatric Acute Lymphoblastic Leukemia in the United States March 14, 2022 March 31, 2028
NCT00593554 Terminated Phase 2 Phase 2 Haplotype Mismatched HSCT in Patients With Hematological Malignancies August 7, 2007 July 28, 2017
NCT02588092 Terminated Phase 1 Study of ADCT-301 in Patients With Relapsed/Refractory CD25-positive Acute Myeloid Leukemia (AML) or CD25-positive Acute Lymphoblastic Leukemia (ALL) February 1, 2016 August 29, 2018
NCT02535806 Terminated Phase 2 Four Drug Reinduction With Bortezomib for Relapsed or Refractory ALL or LL in Children and Young Adults July 2015 May 25, 2017
NCT02535364 Terminated Phase 2 Study Evaluating the Efficacy and Safety of JCAR015 in Adult B-cell Acute Lymphoblastic Leukemia (B-ALL) August 21, 2015 September 1, 2017
NCT02518750 Terminated Phase 2 Re-Induction Therapy for Relapsed Pediatric T-Cell Acute Lymphoblastic Leukemia or Lymphoma November 23, 2016 March 11, 2018
NCT02404220 Terminated Phase 1/Phase 2 Safety and Efficacy of Entospletinib With Vincristine and Dexamethasone in Adults With Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL) May 6, 2015 December 17, 2018
NCT02991898 Terminated Phase 2 Adoptive TReg Cell for Suppression of aGVHD After UCB HSCT for Heme Malignancies February 16, 2017 June 20, 2019
NCT02999854 Terminated Phase 3 Safety and Efficacy of ATIR101 as Adjunctive Treatment to Blood Stem Cell Transplantation From a Haploidentical Family Donor Compared to Post-transplant Cyclophosphamide in Patients With Blood Cancer November 29, 2017 December 17, 2021
NCT02257684 Terminated Phase 2 A Dose Confirmation and Pharmacokinetic Study of Pegcrisantaspase Administered as Intravenous (IV) Infusion in Children and Young Adults With Acute Lymphoblastic Leukemia (ALL) /Lymphoblastic Lymphoma (LBL). Following Hypersensitivity to Pegaspargase (Oncaspar) September 2014 January 2016
NCT02231853 Terminated Phase 1 Phase I/II Trial of Early Infusion of Rapidly-generated Multivirus Specific T Cells (MVST) to Prevent Post Transplant Viral Infections September 3, 2014 December 29, 2017
NCT02065869 Terminated Phase 1/Phase 2 Safety Study of Gene Modified Donor T-cells Following TCRαβ+ Depleted Stem Cell Transplant April 2014 September 7, 2021
NCT01910428 Terminated Phase 1 L-asparaginase Encapsulated in Red Blood Cells (Eryaspase) for Treatment of Adult Patients With ALL or LBL October 2013 March 2018
NCT03195010 Terminated Phase 2 Management of Platelet Transfusion Therapy in Patients With Blood Cancer or Treatment-Induced Thrombocytopenia June 9, 2017 December 21, 2018
NCT01685411 Terminated N/A Busulfan and Cyclophosphamide Followed By ALLO BMT January 2013 February 10, 2020
NCT01685021 Terminated Phase 2 Study of Fc-Optimized Anti-CD19 Antibody (MOR00208) to Treat B-cell Acute Lymphoblastic Leukemia(B-ALL) April 2013 March 2015
NCT03272633 Terminated Early Phase 1 Irradiated Donor Cells Following Stem Cell Transplant in Controlling Cancer in Patients With Hematologic Malignancies October 26, 2020 September 22, 2022
NCT03286114 Terminated Phase 1 Augmentation of the Graft vs. Leukemia Effect Via Checkpoint Blockade With Pembrolizumab December 21, 2017 April 28, 2021
NCT01621477 Terminated Phase 2 T-Cell Replete Haploidentical Donor Hematopoietic Stem Cell Plus Natural Killer (NK) Cell Transplantation in Patients With Hematologic Malignancies Relapsed or Refractory Despite Previous Allogeneic Transplant August 2012 December 2015
NCT01532635 Terminated Phase 2 A Two-Step Approach to Bone Marrow Transplant Using Cells From Two Partially-Matched Relatives March 2012 May 2013
NCT01486043 Terminated N/A Metformin and Transient Hyperglycemia December 2011 May 2013
NCT01483690 Terminated Phase 1/Phase 2 A Pilot Study of Decitabine and Vorinostat With Chemotherapy for Relapsed ALL December 2011 July 31, 2015
NCT01326728 Terminated Relapsed Malignant Blood Cancer After Allogeneic Hematopoietic Stem Cell Transplantation March 30, 2011 July 14, 2017
NCT01312818 Terminated Phase 2 Bortezomib, Vorinostat and Dexamethasone for Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) June 2011 January 2013
NCT03668392 Terminated Phase 2 Asparaginase Activity Monitoring (AAM) in Adult Patients With Acute Lymphoblastic Leukemia (ALL) June 25, 2020 December 31, 2021
NCT01300611 Terminated Phase 1 TXA127 in Enhancement of Engraftment in Adult Double Cord Blood Transplantation January 2011 December 2020
NCT03705507 Terminated Phase 1/Phase 2 International Trial of Selumetinib in Combination With Dexamethasone for the Treatment of Acute Lymphoblastic Leukaemia May 18, 2018 May 3, 2023
NCT03733249 Terminated Phase 1/Phase 2 Long Term Follow-up Study for Patients Enrolled on the BP-004 Clinical Study January 2017 April 14, 2023
NCT03742323 Terminated Phase 1/Phase 2 REALIB-LLA-2017: Idelalisib in Patients With Acute Lymphoblastic Leukemia July 1, 2018 June 2, 2020
NCT01230788 Terminated N/A Rituximab for Patients With Relapsed Acute Lymphoblastic Leukemia September 2010 October 2012
NCT01207076 Terminated Phase 1 AHN-12 Biodistribution in Advanced Leukemia December 2013 July 2014
NCT03860844 Terminated Phase 2 Isatuximab in Combination With Chemotherapy in Pediatric Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia August 6, 2019 May 26, 2023
NCT01195480 Terminated Phase 1/Phase 2 CD19-CAR Immunotherapy for Childhood Acute Lymphoblastic Leukemia (ALL) May 2012 November 2015
NCT01187810 Terminated Phase 1 Fenretinide in Children With Recurrent/Resistant ALL, AML, and NHL August 2010 April 2018
NCT01148134 Terminated Pharmacokinetic Profile of Vincristine Administered With Imatinib for Bcr-Abl Positive Acute Lymphoblastic Leukemia (ALL) Compared to That Without Imatinib for Bcr-Abl Negative ALL June 2010 April 2012
NCT01001390 Terminated N/A The Effects of Ankle Foot Orthoses on Gait Efficiency in Children With Acute Lymphoblastic Leukemia and Foot Drop October 2009 June 2011
NCT00983528 Terminated Phase 1/Phase 2 Alemtuzumab and Clofarabine for Relapsed or Refractory Acute Lymphoblastic Leukemia September 2009 September 2011
NCT04083170 Terminated Phase 2 Cord Blood Transplant With Dilanubicel for the Treatment of HIV Positive Hematologic Cancers October 6, 2022 November 30, 2022
NCT04095858 Terminated Phase 3 Efprezimod Alfa (CD24Fc, MK-7110) for the Prevention of Acute Graft Versus Host Disease (GVHD) Following Myeloablative Hematopoietic Stem Cell Transplantation (HSCT) (MK-7110-005) January 5, 2021 November 5, 2021
NCT00968864 Terminated Phase 2 T-cell Depleted Alternative Donor Transplantation August 2009 November 2016
NCT00967525 Terminated N/A Intraosseous Infusion of Unrelated Cord Blood Grafts March 2007 July 2011
NCT04225676 Terminated Phase 2 Study of Efficacy and Safety of Reinfusion of Tisagenlecleucel in Pediatric and Young Adult Patients With Acute Lymphoblastic Leukemia (ALL) October 19, 2020 October 19, 2021
NCT00961142 Terminated Phase 2 Haploidentical Stem Cell Transplantation With CD3/CD19 Depletion and Reduced Intensity Conditioning in Patients With Acute Leukemia June 2009 December 30, 2015
NCT00944008 Terminated Phase 3 PROCEDYTE: Depocyte® Administration (Liposomal Cytarabine) as Prophylaxis of Neuromeningeal Infiltration in Acute Lymphoblastic Leukemia September 2009 July 2012
NCT00905398 Terminated Phase 1/Phase 2 Nilotinib With Chemotherapy for the Treatment of Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia May 2009 July 2015
NCT00866281 Terminated Phase 1/Phase 2 A Study of the Safety and Preliminary Efficacy of Oral Midostaurin (PKC412) in Relapsed or Refractory Pediatric Leukemia September 2009 September 2014
NCT00790855 Terminated Phase 1/Phase 2 Bendamustine in Acute Leukemia and MDS November 2008 March 2012
NCT04762875 Terminated Phase 2 MGTA-145 + Plerixafor in the Mobilization of HSCs for Allogeneic Transplant in Hematologic Malignancies June 16, 2021 March 14, 2022
NCT00674427 Terminated Phase 1 Trial of Donor Lymphocyte Infusion (DLI) and Activated DLI Following Relapse After Allogeneic Stem Cell Transplant January 2008 January 2012
NCT00658411 Terminated N/A Deferoxamine for Iron Overload Before Allogeneic Stem Cell Transplantation August 2008 December 2011
NCT02669264 Terminated Phase 1 Study of ADCT-402 in Patients With Relapsed or Refractory B-cell Lineage Acute Lymphoblastic Leukemia (B-ALL) March 2016 July 3, 2018
NCT00579111 Terminated Phase 1/Phase 2 Reduced Intensity Preparative Regimen Followed by Stem Cell Transplant (FAB) June 2007 October 2010
NCT00522990 Terminated Phase 1/Phase 2 Study to Assess the Safety of Escalating Doses of AT9283, in Patients With Leukemias September 2006 April 2009
NCT00514722 Terminated N/A Pilot Study of Umbilical Cord Blood Transplantation in Adult Patient With Advanced Hematopoietic Malignancies October 2002 March 2009
NCT00513318 Terminated Pilot Study of Reduced-Intensity Umbilical Cord Blood Transplantation in Adult Patients Wtih Advanced Hematopoietic Malignancies August 2004 June 2009
NCT05410574 Terminated N/A Family-Based Behavioral Treatment for Childhood Survivors of Acute Lymphoblastic Leukemia July 22, 2022 March 26, 2024
NCT00439296 Terminated Phase 1/Phase 2 ABT-751 With Chemotherapy for Relapsed Pediatric ALL May 22, 2006 September 23, 2009
NCT00346632 Terminated Phase 1 An Ascending Dose Study of KW-2449 in Acute Leukemias, Myelodysplastic Syndromes, and Chronic Myelogenous Leukemia June 2006 April 2008
NCT00276159 Terminated Phase 2 Study of Immune Response Modifier in the Treatment of Hematologic Malignancies January 2006 November 2008
NCT00187005 Terminated Phase 3 Total Therapy Study XIV for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia July 1998 July 2002
NCT00165087 Terminated Phase 3 Treatment of Childhood Acute Lymphoblastic Leukemia January 1996 September 2006
NCT02339350 Unknown status Phase 2 Treatment of Newly Diagnosed High Risk Acute Lymphoblastic Leukemia in Children January 2015 April 2023
NCT02451774 Unknown status Phase 2/Phase 3 Pentoxifylline In Pediatric Acute Lymphoblastic Leukemia During Induction January 2015 December 2020
NCT04969601 Unknown status Phase 1/Phase 2 Anti-Covid-19 Vaccine in Children With Acute Leukemia and Their Siblings September 29, 2021 March 29, 2023
NCT03318419 Unknown status Phase 2 Cladribine in Combination With GAP in Patients With Refractory/Relapsed Acute Lymphoblastic Leukemia January 1, 2016 December 31, 2020
NCT03298828 Unknown status Phase 1 CD19 CAR and PD-1 Knockout Engineered T Cells for CD19 Positive Malignant B-cell Derived Leukemia and Lymphoma November 2017 October 2022
NCT03278145 Unknown status Dependence Receptors and Leukemia November 2017 November 2019
NCT02744768 Unknown status Phase 2 D-ALBA Frontline Sequential Dasatinib and Blinatumomab in Adult Philadelphia Positive Acute Lymphoblastic Leukemia May 31, 2017 June 2021
NCT03249636 Unknown status New Markers for Minimal Residual Disease in Acute Lymphoblastic Leukemia December 2017 October 2019
NCT01873807 Unknown status Phase 4 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL May 2013 December 2015
NCT01906671 Unknown status Phase 4 Study on Two Different Formulations of 6-mercaptopurine. Tablet Versus Oral Liquid June 2013 November 2018
NCT02007811 Unknown status Phase 1/Phase 2 Open-label Clinical Trial to Investigate the Safety and Tolerability of Allogeneic B-cell Concentrates for Immune Reconstitution After Allogeneic Stem Cell Transplantation Measured as Response to a Antedated Single Vaccination November 2013 December 2015
NCT02070523 Unknown status Phase 3 Pegylated Liposomal Doxorubicin Versus Daunorubicin to Treat Acute Lymphoblastic Leukemia: December 2013 December 2015
NCT02186860 Unknown status Phase 1 Chimeric Antigen Receptor (CAR)-Modified T Cell Therapy in Treating Patients With Acute Lymphoblastic Leukemia July 2016 December 2021
NCT03027739 Unknown status Phase 2/Phase 3 CART-19 Cells For MRD Positive CD19+ ALL November 2016 December 2020
NCT02290132 Unknown status ATG Could Improve the Outcome Of Hematopoietic Stem Cell Transplant in Patients With Highly Aggressive T Cell Tumors August 2013 July 2017
NCT02965092 Unknown status Phase 1/Phase 2 CD19 Chimeric Antigen Receptor (CAR)-Modified T Cell Therapy in Treating Patients With B-cell Malignancies December 2, 2015 December 2021
NCT02310243 Unknown status Phase 1/Phase 2 Study of Palbociclib in MLL-rearranged Acute Leukemias July 2015 July 2019
NCT05326984 Unknown status N/A Effect of Metformin on ABCB1 and AMPK Expression in Adolescents With Newly Diagnosed Acute Lymphoblastic Leukemia February 9, 2021 December 2023
NCT00439920 Unknown status Phase 2 GIMEMA LAL 0496: High-dose Anthracycline in the Induction Regimen for the Treatment of Adult ALL. October 1996 December 2018
NCT05133310 Unknown status Phase 4 Effect of Simvastatin on Sepsis and Febrile Neutropenia in Patients With Acute Lymphoblastic Leukemia November 19, 2021 June 23, 2023
NCT00774332 Unknown status Phase 2 A Phase II Study of CODOX-M/ IVAC in Relapsed/Refractory ALL June 2006 December 2009
NCT00402090 Unknown status DHPLC Determination of TPMT Polymorphisms. April 2005 November 2006
NCT04814004 Unknown status Phase 1 Clinical Study of CAR-iNKT Cells in the Treatment of Relapsed/Refractory/High-risk B-cell Tumors March 19, 2021 April 1, 2024
NCT04796688 Unknown status Phase 1 Universal Chimeric Antigen Receptor-modified AT19 Cells for CD19+ Relapsed/Refractory Hematological Malignancies March 10, 2021 March 10, 2024
NCT04677231 Unknown status Evaluation of Long-term Health Status and Quality of Life in Adult Survivors With Philadelphia-negative Acute Lymphoblastic Leukemia/Lymphoma Treated With an Intensive Pediatric or Pediatric-inspired Protocol January 2021 March 2024
NCT00797810 Unknown status Phase 4 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults December 2006
NCT00846703 Unknown status Phase 4 The GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia July 2008 December 2018
NCT04554381 Unknown status Phase 1 Assesment of JL1 Expression in Acute Leukemia October 13, 2020 November 2023
NCT04488237 Unknown status Vitamin D and Methotrexate Adverse Effects September 2020 December 2021
NCT04364451 Unknown status Correlation of Polymorphisms of Lipoprotein Lipase (LpL) and Apolipoprotein E (Apo E) With Lipid Profile of Children With Acute Lymphoblastic Eukaemia During Therapy With L - Asparaginase. September 1, 2019 August 31, 2022
NCT04226989 Unknown status Early Phase 1 A Study of CT-RD06 Cell Injection in Patients With Relapsed or Refractory CD19+ B-cell Hematological Malignancy February 5, 2020 May 31, 2024
NCT04206943 Unknown status Phase 1/Phase 2 Study of CD19 Specific Chimeric Antigen Receptor Positive T Cells (CAR-T) in ALL and NHL October 12, 2019 January 1, 2021
NCT00328237 Unknown status Phase 2 Treatment of Hematologic Malignancies With Single-Unit or Double-Unit Cord Blood Transplantation November 2005
NCT00961285 Unknown status Genotyping Analysis of Acute Lymphoblastic Leukemia March 2009 December 2012
NCT04168788 Unknown status N/A Pharmacogenetic Study of Antimitotic Therapies Involved in Hepatic VOD in Children With Nephroblastoma or ALL January 1, 2020 January 1, 2022
NCT04158011 Unknown status A Retrospective Study of Patients With Leukemia Relapse in the CNS Treated With CAR T Cells November 6, 2019 January 1, 2021
NCT04154709 Unknown status Phase 1 CTA101 UCAR-T Cell Injection for Treatment of Relapsed or Refractory CD19+ B-cell Acute Lymphoblastic Leukemia December 10, 2019 June 2022
NCT00982514 Unknown status Thromboembolic Complications Related to Asparaginase in Children With Acute Lymphoblastic Leukemia (ALL) Treated According to NOPHO ALL 2008 September 2009 December 2014
NCT04096846 Unknown status Effect of Vitamin D Diffiency on Oral Mucosa in Patients Recieving Methotrexate Chemotherapy November 1, 2019 December 1, 2020
NCT01079507 Unknown status Genome-wide Single Nucleotide Polymorphism (SNP) Array-based Approach to Predict Chemoresponse and Survival in Patients With Acute Lymphoblastic Leukemia February 2010
NCT02810223 Unknown status Phase 1 Efficacy of CART-19 Cell Therapy in B Cell Acute Lymphoblastic Leukemia May 2016
NCT00222612 Unknown status Phase 4 Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 October 2003 August 2013
NCT01089907 Unknown status Genomic Changes in Childhood Acute Lymphoblastic Leukemia April 2010 June 2013
NCT04008251 Unknown status Phase 1 Humanized CD19 Chimeric Antigen Receptor (CAR)-Modified T Cell Therapy in Treating Patients With B-cell Malignancies May 27, 2019 December 31, 2022
NCT04007978 Unknown status Phase 1 Anti-CD22 Chimeric Antigen Receptor (CAR)-Modified T Cell Therapy for Relapsed Refractory B-cell Malignancies August 5, 2019 December 30, 2022
NCT01104324 Unknown status Osteonecrosis in Children With Acute Lymphoblastic Leukemia July 2009 December 2012
NCT03920813 Unknown status Phase 4 Determinants of Mercaptopurine Toxicity in Paediatric Acute Lymphoblastic Leukemia Maintenance Therapy January 2015 December 2021
NCT03902197 Unknown status Phase 2 CD19 hsCAR-T for Refractory/Relapsed CD19+ B-ALL Patients April 22, 2019 December 21, 2023
NCT03898128 Unknown status ItaliaN Observational Study of Patients With Acute Lymphoblastic Leukemia Treated With Anti-CD22 Immunoconjugate November 27, 2019 September 2021
NCT03887156 Unknown status Phase 2/Phase 3 Evaluation of a Donor Testing Kit for the Prediction of AGVHD in Patient Receiving a Peripheral Blood Stem Cell Allograft September 16, 2019 March 16, 2023
NCT03798509 Unknown status Phase 1 Human CD19 Targeted T Cells Injection Therapy for Relapsed and Refractory CD19-positive Leukemia March 13, 2019 January 2024
NCT03655145 Unknown status Phase 3 HLA 10/10 Matched Unrelated Donor vs Haploidentical Allogenic Hematopoietic Stem Cell Transplantation August 2018 June 2023
NCT00192673 Unknown status Phase 4 Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses June 2005 December 2013
NCT01354457 Unknown status Phase 1/Phase 2 Safety and Efficacy of Radio-immunotherapy (RIT) for Patients With Relapse or Refractory Acute Lymphoblastic Leukaemia (ALL) B CD22+ November 2010 June 2016
NCT01358201 Unknown status Phase 4 PETHEMA LAL-07FRAIL: All Treatment In Fragile Patients Ph' Negative Over 55 Years May 2010 December 2022
NCT01366898 Unknown status Phase 4 Protocol For the Treatment Acute Lymphoblastic Leukemia With Ph 'Negative in Elderly Patients (> 55 Years) June 30, 2007 December 2022
NCT01513603 Unknown status Phase 2 Trial of Cladribine, Cytarabine, Mitoxantrone, Filgrastim (CLAG-M) in Relapsed Acute Lymphoblastic Leukemia January 2012 January 2014
NCT03366350 Unknown status Phase 1/Phase 2 Anti-CD19 CAR-T Therapy Bridging to HSCT for CD19+ B-Cell Malignancies April 15, 2016 June 1, 2021
NCT03366324 Unknown status Phase 1/Phase 2 Anti-CD19 CAR-T Therapy Combine With HSCT to Treat MRD+ B-cell Malignancies May 1, 2016 June 1, 2021
NCT04845035 Withdrawn Phase 2 Pediatric-Inspired Chemotherapy Plus Tyrosine Kinase Inhibitor in Adult Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia January 2024 January 2029
NCT02815059 Withdrawn Phase 1 Study of Pts With Philadelphia Chromosome-Pos ALL With Comb of Ibrutinib, Dasatinib, and Prednisone September 28, 2016 January 9, 2018
NCT05168748 Withdrawn Phase 1 CD19- and CD22-directed CAR-T Cell Therapy in Patients With Acute Lymphoblastic Leukemia January 24, 2023 August 13, 2026
NCT03628053 Withdrawn Phase 3 Tisagenlecleucel vs Blinatumomab or Inotuzumab for Patients With Relapsed/Refractory B-cell Precursor Acute Lymphoblastic Leukemia June 5, 2020 January 7, 2026
NCT05037669 Withdrawn Phase 1 Programmed Allogeneic CRISPR-edited T Cells Engineered to Express Anti-CD19 Chimeric Antigen Receptor (PACE CART19) in Patients With Relapsed Or Refractory CD19+ Leukemia and Lymphoma July 2022 January 2038
NCT03982992 Withdrawn Phase 2 Allogeneic Donor Lymphocyte Infusions Combined With Blinatumomab June 1, 2019 November 30, 2021
NCT03141398 Withdrawn Comparing CGM and OGTT in Relation to Iron Overload Detected by Pancreas T2* MRI in High-Risk Hematology Group August 2017 December 2018
NCT00349518 Withdrawn Phase 2/Phase 3 Study of Dasatinib in Imatinib Resistant or Intolerant Subjects With Chronic or Advanced Phase CML or Philadelphia Chromosome Positive ALL December 2006
NCT01677949 Withdrawn Phase 2 Clofarabine, Cyclophosphamide and Etoposide for Minimal Residual Disease Positive Acute Leukemia December 2013 January 2016
NCT02632903 Withdrawn Phase 2 Intravenous Zoledronic Acid for the Treatment of Osteoporosis and Osteonecrosis in Children With Leukemia: A Pilot Study October 2016 August 20, 2018
NCT01688752 Withdrawn Cardiometabolic Status in Childhood Acute Lymphoblastic Leukemia
NCT00900445 Withdrawn Studying Body Mass Index in Younger Patients Who Are Receiving Treatment for High-Risk Acute Lymphoblastic Leukemia March 24, 2008
NCT05321940 Withdrawn Phase 1 Safety Trial of STING-dependent Activators and Stimulated Dendritic Cells for Aggressive Relapsed/Refractory Leukemias November 30, 2023 November 30, 2026
NCT00957320 Withdrawn Phase 1 Study of Sirolimus With PEG-Asparaginase in Acute Lymphoblastic Leukemia (ALL) June 2009 August 2012
NCT04282174 Withdrawn Phase 2 CD34+ Enriched Transplants From HLA-Compatible Patients With Hematologic Malignancies September 2022 March 1, 2030
NCT03768310 Withdrawn Phase 1 CD19.CAR-multiVSTs for Patients With CD19+ B-ALL or NHL Undergoing Related Allogeneic HSCT (CARMA) June 2022 August 2040
NCT03187691 Withdrawn Phase 2 Safety and PK of Oral Encochleated Amphotericin B (CAMB/MAT2203) for Antifungal Prophylaxis in Patients Undergoing Induction Chemotherapy for Acute Myelogenous and Lymphoblastic Leukaemia August 2019 December 2020
Disase is a (Disease Ontology)
DOID:12603
Cross Reference ID (Disease Ontology)
EFO:0000220
Cross Reference ID (Disease Ontology)
GARD:522
Cross Reference ID (Disease Ontology)
ICD10CM:C91.00
Cross Reference ID (Disease Ontology)
ICD9CM:204.0
Cross Reference ID (Disease Ontology)
MIM:247640
Cross Reference ID (Disease Ontology)
MIM:613065
Cross Reference ID (Disease Ontology)
NCI:C3167
Cross Reference ID (Disease Ontology)
NCI:C7055
Cross Reference ID (Disease Ontology)
ORDO:513
Cross Reference ID (Disease Ontology)
SNOMEDCT_US_2023_03_01:128822004
Cross Reference ID (Disease Ontology)
UMLS_CUI:C0023449
Cross Reference ID (Disease Ontology)
UMLS_CUI:C1335469
Exact Synonym (Disease Ontology)
acute lymphoblastic leukaemia
Exact Synonym (Disease Ontology)
acute lymphocytic leukaemia
Exact Synonym (Disease Ontology)
ALL
Exact Synonym (Disease Ontology)
precursor lymphoblastic lymphoma/leukemia
HPO alt_id (Human Phenotype Ontology)
HP:0004803
HPO alt_id (Human Phenotype Ontology)
HP:0005555
HPO Human Phenotype ID (Human Phenotype Ontology)
HP:0006721
OrphaNumber from OrphaNet (Orphanet)
513