Annotation Detail
Information
- Associated Genes
- PDGFRA
- Associated Variants
- PDGFRA EXPRESSION
- Source Database
- MMMP
- Description
- Imatinib: small molecule inhibitor of tyrosine kinase receptors (TKR) such as KIT and PDGFR. This study supports an antiproliferative effect of imatinib (STI571) on cultured human cutaneous melanoma-derived cell lines: however, no relationship could be established between the expression of c-Kit, ABL, PDGFR-alpha or PDGFR-beta and the response of cell lines to STI571. The identification of an unknown target of STI571 in human cutaneous melanoma cells would allow the selection of patients who could benefit from this treatment
- MMMP State
- expressed
- MMMP Molecule
- PDGFRA
- MMMP Molecule Alias
- PDGF receptor alpha
- MMMP Relationship
- no relationship with
- MMMP Drug
- Imatinib
- MMMP Drug Alias
- Gleevec (R)
- MMMP Model
- 3
- MMMP Reference
- Mayorga ME, Melanoma Res 2006, 16:127-35
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Imatinib | Resitance or Non-Reponse | true |