Annotation Detail
Information
- Associated Genes
- KIT
- Associated Variants
- KIT WILD_TYPE
- Source Database
- MMMP
- Description
- Mucosal melanoma.Mucosal melanoma cells exhibited imatinib sensitivity correlating with KIT mutational status (imatinib decreased proliferation and was cytotoxic to KIT mutated but not wild type melanoma cells)
- MMMP State
- wild type
- MMMP Molecule
- KIT
- MMMP Molecule Alias
- c-KIT
- MMMP Relationship
- resistance to
- MMMP Drug
- Imatinib
- MMMP Drug Alias
- Gleevec (R)
- MMMP Model
- 3
- MMMP DNA/mRNA/Protein
- DNA
- MMMP Reference
- Jiang X, Clin Cancer Res 2008, 14:7726-32
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Imatinib | Resitance or Non-Reponse | true |