Annotation Detail

Information
Associated Genes
KIT
Associated Variants
KIT EXPRESSION
Source Database
MMMP
Description
Uveal melanoma; no KIT mutations found. The results confirm that c-Kit is vastly expressed in uveal melanoma, suggest that the c-Kit molecular pathway may be important in uveal melanoma growth, and point to its use as a target for therapy with imatinib (STI571)
MMMP Relationship
sensitivity to
MMMP Drug
Imatinib
MMMP Drug Alias
Gleevec (R)
MMMP Model
3
MMMP State
expressed
MMMP Molecule
KIT
MMMP Molecule Alias
c-KIT
MMMP Reference
All-Ericsson C, Invest Ophthalmol Vis Sci 2004, 45:2075-82
MMMP DNA/mRNA/Protein
protein
Drugs
Drug NameSensitivitySupported
ImatinibSensitivitytrue