Annotation Detail

Information
Associated Genes
CSF1R
Associated Variants
CSF1R MEF2D-CSF1R
Associated Disease
acute lymphoblastic leukemia
Source Database
CIViC Evidence
Description
Cell lines with MEF2D-CSF1R fusion show sensitivity to the tyrosine kinase inhibitors Imatinib and GW-2580.
Variant Origin
somatic
Variant Origin
Somatic
Evidence URL
https://civic.genome.wustl.edu/links/evidence_items/403
Gene URL
https://civic.genome.wustl.edu/links/genes/33
Variant URL
https://civic.genome.wustl.edu/links/variants/30
Rating
3
Evidence Type
Predictive
Disease
Acute Lymphoblastic Leukemia
Evidence Direction
Supports
Drug
GW-2580,Imatinib
Evidence Level
D
Clinical Significance
Sensitivity/Response
Pubmed
24186003
Drugs
Drug NameSensitivitySupported
GW-2580Sensitivitytrue
ImatinibSensitivitytrue