Annotation Detail
Information
- Associated Genes
- KIT
- Associated Variants
-
KIT EXON 11 MUTATION
KIT EXON 11 MUTATION - Associated Disease
- melanoma
- Source Database
- CIViC Evidence
- Description
- Melanoma patients with KIT mutation but not KIT amplification showed response to imatinib treatment in a small cohort of patients.
- Drug
- Imatinib
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/58
- Gene URL
- https://civic.genome.wustl.edu/links/genes/29
- Variant URL
- https://civic.genome.wustl.edu/links/variants/66
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Melanoma
- Evidence Direction
- Supports
- Evidence Level
- B
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 23775962
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Imatinib | Sensitivity | true |