gastrointestinal stromal tumor (Cancer)
Information
- Disease name
- gastrointestinal stromal tumor
- Disease ID
- DOID:9253
- Description
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT02834013 | Active, not recruiting | Phase 2 | Nivolumab and Ipilimumab in Treating Patients With Rare Tumors | January 30, 2017 | May 1, 2026 |
| NCT00265798 | Active, not recruiting | Phase 2 | Sorafenib in Treating Patients With Malignant Gastrointestinal Stromal Tumor That Progressed During or After Previous Treatment With Imatinib Mesylate and Sunitinib Malate | September 14, 2005 | March 8, 2025 |
| NCT00004910 | Completed | Phase 1/Phase 2 | Endoscopic Placement of Metal Stents in Treating Patients With Cancer- Related Duodenal Obstruction | January 2000 | February 2003 |
| NCT00004911 | Completed | Phase 1/Phase 2 | Endoscopic Placement of Metal Stent in Patients With Cancer-Related Bowel Obstruction | January 2000 | February 2003 |
| NCT00005049 | Completed | Phase 2 | Combination Chemotherapy in Treating Patients With Stage III Ovarian Epithelial Cancer or Gastrointestinal Cancer | May 1997 | |
| NCT00005597 | Completed | Phase 2 | S9926 Temozolomide in Patients With Unresectable/Metastatic Gastrointestinal Stromal Tumors | April 2000 | October 2005 |
| NCT00005862 | Completed | Phase 2 | SU5416 in Treating Patients With Advanced, Metastatic, or Recurrent Soft Tissue Sarcomas | October 2000 | |
| NCT00005874 | Completed | Phase 2 | Nitrocamptothecin in Treating Patients With Soft Tissue Sarcomas | June 1999 | April 2004 |
| NCT00006357 | Completed | Phase 1/Phase 2 | STI571 in Treating Patients With Recurrent or Refractory Soft Tissue Sarcoma | August 2000 | |
| NCT00003939 | Completed | Phase 2 | Ecteinascidin 743 in Treating Patients With Advanced Soft Tissue Sarcoma | ||
| NCT00025246 | Completed | Phase 2 | Imatinib Mesylate in Treating Patients With Gastrointestinal Stromal Tumor That Has Been Completely Removed During Surgery | September 2001 | |
| NCT00025415 | Completed | Phase 1 | Imatinib Mesylate in Treating Patients With Advanced Cancer and Liver Dysfunction | August 2001 | |
| NCT00028002 | Completed | Phase 2 | Neoadjuvant and Adjuvant Imatinib Mesylate in Treating Patients With Primary or Recurrent Malignant Gastrointestinal Stromal Tumor | March 31, 2002 | January 28, 2009 |
| NCT00030667 | Completed | Phase 2 | Imatinib Mesylate in Treating Patients With Relapsed or Refractory Solid Tumors of Childhood | May 2002 | December 2005 |
| NCT00031681 | Completed | Phase 1 | 7-Hydroxystaurosporine and Irinotecan Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007) | December 2001 | |
| NCT00041197 | Completed | Phase 3 | Imatinib Mesylate in Treating Patients With Primary Gastrointestinal Stromal Tumor That Has Been Completely Removed By Surgery | June 2002 | |
| NCT00041249 | Completed | Phase 2 | Brostallicin in Treating Patients With Locally Advanced or Metastatic Soft Tissue Sarcoma | May 2002 | |
| NCT00069940 | Completed | Phase 1 | Vaccine Therapy and Sargramostim in Treating Patients With Sarcoma or Brain Tumor | December 2000 | August 2008 |
| NCT00075218 | Completed | Phase 3 | A Study To Assess The Safety And Efficacy Of SU11248 In Patients With Gastrointestinal Stromal Tumor(GIST) | December 2003 | May 2008 |
| NCT00087074 | Completed | Phase 2 | CCI-779 in Treating Patients With Soft Tissue Sarcoma or Gastrointestinal Stromal Tumor | June 2004 | |
| NCT04256226 | Completed | Clinical Outcome of Female Non-gastric Gastrointestinal Stromal Tumor | February 1, 2020 | March 31, 2020 | |
| NCT02884154 | Completed | N/A | Feasibility and Yield of a New 20 G ProCore Needle With Coiled Sheath in the Gastrointestinal Subepithelial Tumors | August 2016 | July 2017 |
| NCT00098579 | Completed | Phase 1 | Doxorubicin Hydrochloride and Alvocidib in Treating Patients With Metastatic or Recurrent Sarcoma That Cannot Be Removed By Surgery | October 2004 | |
| NCT00103168 | Completed | Phase 3 | Imatinib Mesylate or Observation Only in Treating Patients Who Have Undergone Surgery for Localized Gastrointestinal Stromal Tumor | December 2004 | September 2017 |
| NCT00112463 | Completed | Phase 2 | Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma | January 7, 2005 | October 23, 2008 |
| NCT00112632 | Completed | Phase 2 | Imatinib Mesylate in Treating Patients With Locally Advanced Gastrointestinal Stromal Tumor | February 2005 | |
| NCT02880020 | Completed | Phase 2 | Nivolumab With or Without Ipilimumab in Treating Patients With Gastrointestinal Stromal Tumor That Is Metastatic or Cannot Be Removed by Surgery | December 14, 2016 | August 9, 2022 |
| NCT00397384 | Completed | Phase 1 | Erlotinib Hydrochloride and Cetuximab in Treating Patients With Advanced Gastrointestinal Cancer, Head and Neck Cancer, Non-Small Cell Lung Cancer, or Colorectal Cancer | January 2007 | June 2013 |
| NCT00428220 | Completed | N/A | A Continuation Study Using Sunitinib Malate For Patients Leaving Treatment On A Previous Sunitinib Study. | July 2007 | September 2014 |
| NCT00568750 | Completed | Phase 2 | Dasatinib as First-Line Therapy in Treating Patients With Gastrointestinal Stromal Tumors | January 22, 2008 | May 16, 2018 |
| NCT02686944 | Completed | Phase 1 | A Study to Evaluate the Safety of Intuvax Administered Intra-tumorally in Patients With Gastrointestinal Stromal Tumors | June 1, 2016 | May 10, 2019 |
| NCT00654160 | Completed | Phase 1 | Irinotecan, Fluorouracil, and Leucovorin in Treating Patients With Advanced Gastrointestinal Cancer | June 2008 | December 3, 2012 |
| NCT02164240 | Completed | Phase 1 | Phase Ib Study of SUnitinib Alternating With REgorafenib in Patients With Metastatic and/or Unresectable GIST | July 2014 | May 2021 |
| NCT00764595 | Completed | Phase 2 | Imatinib Mesylate in Treating Patients With Liver Metastasis From a Gastrointestinal Stromal Tumor | October 2008 | March 2016 |
| NCT00769782 | Completed | Phase 2 | Surgery in Treating Patients With Liver Metastasis From a Gastrointestinal Stromal Tumor | October 2008 | March 2016 |
| NCT02103322 | Completed | Phase 2/Phase 3 | Comparative Bioequivalence Study in Adult Patients Suffering From Chronic Myeloid Leukemia & Gastrointestinal Stromal Tumor Under Fed Conditions | February 2014 | June 2014 |
| NCT00954655 | Completed | Study of Tumor Samples in Patients Undergoing Treatment for Gastrointestinal Stromal Tumors on Clinical Trial ACOSOG-Z9001 | December 2008 | April 2013 | |
| NCT01865565 | Completed | Surgery for Locally Unresectable Advanced GISTs Without Metastasis After Imatinib Therapy | January 1, 2013 | December 31, 2017 | |
| NCT01039519 | Completed | Phase 2 | A Study Evaluating STA-9090 in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor (GIST) | January 2010 | December 2011 |
| NCT01068769 | Completed | Phase 2 | Regorafenib in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor | February 2010 | August 2020 |
| NCT01110668 | Completed | Phase 2 | Evaluation of Nilotinib In Patients With Advanced Gastrointestinal Stromal Tumor (GIST) | September 2008 | September 2011 |
| NCT01154452 | Completed | Phase 1/Phase 2 | Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma | June 2010 | February 2015 |
| NCT01267695 | Completed | Phase 2 | Perioperative Imatinib Mesylate in Treating Patients With Locally Advanced Gastrointestinal Stromal Tumor | May 2010 | October 2014 |
| NCT01774162 | Completed | N/A | EUS-guided Fine Needle Biopsy With a New Core Histology Needle Versus Conventional Fine Needle Aspiration | September 2011 | June 2012 |
| NCT01404650 | Completed | Phase 2 | Study of Hsp90 Inhibitor AUY922 for the Treatment of Patients With Refractory Gastrointestinal Stromal Tumor | December 2011 | February 2015 |
| NCT01560260 | Completed | Phase 2 | Linsitinib in Treating Patients With Gastrointestinal Stromal Tumors | March 2012 | October 2015 |
| NCT01751919 | Completed | Phase 1 | A Clinical Trial to Compare the Pharmacokinetics of Imatinib Mesylate Tablet 400mg (1 Tablet) and Glivec Film-coated Tablet 100mg (4 Tablets)(Phase I) | May 2012 | August 2012 |
| NCT00004895 | Completed | Phase 2 | Octreotide as Palliative Therapy for Cancer-Related Bowel Obstruction That Cannot Be Removed by Surgery | October 1999 | October 2002 |
| NCT01769248 | Completed | N/A | Prospective Trial of EUS-FNA Versus EUS-FNB Using a Novel Core Biopsy Needle | September 2012 | February 2014 |
| NCT01643278 | Completed | Phase 1 | Dasatinib and Ipilimumab in Treating Patients With Gastrointestinal Stromal Tumors or Other Sarcomas That Cannot Be Removed by Surgery or Are Metastatic | July 2012 | June 2016 |
| NCT01613053 | No longer available | Continuation of Drug Supply in Chinese Patients After CAMN107DBR01study Termination | |||
| NCT04933669 | Recruiting | Phase 2 | Prospective Multicenter Clinical Study of Neoadjuvant Imatinib Mesylate for Gastrointestinal Stromal Tumors | September 7, 2021 | December 31, 2029 |
| NCT02924714 | Suspended | N/A | SSG XXV: The Stop-GIST Trial; Discontinuation of Imatinib in Patients With Oligo-metastatic GIST | January 2017 | November 2022 |
| NCT03493152 | Temporarily not available | Expanded Access to Everolimus, for an Individual Patient With GIST (Gastrointestinal Stromal Tumors)(CTMS#18-0019) | |||
| NCT00372567 | Terminated | Phase 3 | Safety And Effectiveness Of Daily Dosing With Sunitinib Or Imatinib In Patients With Gastrointestinal Stromal Tumors | June 2007 | November 2009 |
| NCT00324987 | Terminated | Phase 3 | Imatinib Mesylate With or Without Bevacizumab in Treating Patients With Metastatic or Unresectable Gastrointestinal Stromal Tumor | April 2008 | July 2015 |
| NCT00091078 | Terminated | Phase 2 | Oblimersen and Imatinib Mesylate in Treating Patients With Advanced Gastrointestinal Stromal Tumors That Cannot Be Removed By Surgery | September 2005 | |
| NCT00573404 | Terminated | Phase 1 | Imatinib Mesylate and Sunitinib in Treating Patients With Gastrointestinal Stromal Tumors | July 2007 | March 2011 |
| NCT00009906 | Terminated | Phase 3 | Comparison of Two Different Doses of STI571 in Treating Patients With Metastatic or Unresectable Gastrointestinal Stromal Tumor | December 2000 | November 2014 |
| NCT00956072 | Terminated | Phase 3 | Imatinib Mesylate With or Without Surgery in Treating Patients With Metastatic Gastrointestinal Stromal Tumor That is Responding to Imatinib Mesylate | May 2009 | |
| NCT00087191 | Terminated | N/A | EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or Non-Small Cell Lung Cancer | May 2004 | |
| NCT02185937 | Terminated | Phase 1 | Influence of an Acidic Beverage on the Imatinib Exposure After Major Gastrectomy | August 2014 | November 2016 |
| NCT04143048 | Unknown status | A Study on Non-invasive Early Diagnosis of Gastrointestinal Stromal Tumors and Differentiation of Benign and Malignant Nodules | September 1, 2019 | May 31, 2020 | |
| NCT02763748 | Unknown status | N/A | the Laparoscopic and Endoscopic Cooperative Surgery of Gastrointestinal Stromal Tumor | June 2016 | December 2018 |
| NCT00777504 | Unknown status | Phase 4 | Study to the Optimal Duration of Therapy With Oral Angiogenesis Inhibitors | October 2008 | April 2012 |
| NCT00685828 | Unknown status | Phase 3 | Imatinib Mesylate in Treating Patients With Unresectable or Metastatic Gastrointestinal Stromal Tumor | January 2001 | |
| NCT02336724 | Unknown status | Phase 2 | A Study of Famitinib in Patients With Gastrointestinal Stromal Tumor | March 2012 | June 2019 |
| NCT02353052 | Unknown status | Prospective Cohort Study of the Clinical Applications for the Pathologic Type, Staging, and Grading of GIST | July 2013 | ||
| NCT02426762 | Unknown status | Phase 2 | Quick Skin Sealant in Closure of Surgical Wound After Laparoscopic Surgery | February 2015 | October 2015 |
| NCT02576080 | Unknown status | Phase 3 | Efficacy of Imatinib in Patients With Intermediate-risk Gastrointestinal Stromal Tumor With a High-risk Genomic Grade Index | October 2015 | October 2020 |
| NCT01389583 | Unknown status | Phase 2 | A Study of AUY922 for GIST(Gastrointestinal Stromal Tumor) Patients | October 2011 | October 2019 |
| NCT02776878 | Unknown status | N/A | A Clinical Trial Evaluating the Efficacy and Safety of Dasatinib in Refractory Metastatic GIST | May 2016 | May 2018 |
| NCT02931981 | Unknown status | Serum Dickkopf-4 as a Biomarker for the Diagnosis and Treatment of Gastrointestinal Stromal Tumor | October 2016 | October 2019 | |
| NCT02734823 | Withdrawn | Long Term Effects of Tyrosine Kinase Inhibitor Therapy on Ovarian Reserve and Fertility in Patients With Chronic Myeloid Leukemia or Gastrointestinal Stromal Tumor | March 1, 2016 | March 14, 2024 |
- Disase is a (Disease Ontology)
- DOID:3119
- Cross Reference ID (Disease Ontology)
- GARD:8598
- Cross Reference ID (Disease Ontology)
- ICD10CM:C49.A
- Cross Reference ID (Disease Ontology)
- ICDO:8936/3
- Cross Reference ID (Disease Ontology)
- MESH:D046152
- Cross Reference ID (Disease Ontology)
- MIM:606764
- Cross Reference ID (Disease Ontology)
- NCI:C3868
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:1187383001
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C0238198
- Exact Synonym (Disease Ontology)
- GANT
- Exact Synonym (Disease Ontology)
- gastrointestinal stromal tumour
- Exact Synonym (Disease Ontology)
- GIST
- Exact Synonym (Disease Ontology)
- Stromal tumor of gastrointestinal tract
- Exact Synonym (Disease Ontology)
- Stromal tumour of gastrointestinal tract
- OrphaNumber from OrphaNet (Orphanet)
- 44890