Annotation Detail
Information
- Associated Genes
- KITLG
- Associated Variants
- KITLG EXPRESSION
- Source Database
- MMMP
- Description
- Uveal melanoma. In this phase II trial of imatinib for the treatment of advanced uveal melanoma, no objective response was observed, despite the fact that c-KIT was overexpressed in 55% of primary tumors and in 76% of metastatic samples (no KIT mutations found), and SCF was overexpressed in 43% of primary tumors and in 58% of metastatic samples
- MMMP State
- expressed
- MMMP Molecule
- SCF
- MMMP Relationship
- no relationship with
- MMMP Drug
- Imatinib
- MMMP Drug Alias
- Gleevec (R)
- MMMP Model
- 5
- MMMP Reference
- Hofmann UB, Clin Cancer Res 2009, 15:324-9
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Imatinib | Resitance or Non-Reponse | true |