Fluorouracil

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Information
Drug Name
Fluorouracil
Description
Entry(CIViC)
22
CIViC
Disease Mutation EL ET ED CS VO TR Pubmed Links
gastric adenocarcinoma HSPH1 NUCLEAR EXPRESSION HSPH1 NUCLEAR EXPRESSION D Predictive Supports Sensitivity/Response N/A 1 26943774 Detail
colorectal cancer HSPH1 T17 DELETION
( ENST00000320027.10 ) HSPH1 T17 DELETION
( ENST00000320027.10 )
B Predictive Supports Sensitivity/Response Somatic 2 24512910 Detail
pancreatic adenocarcinoma RB1 OVEREXPRESSION
( ENST00000267163.6 ) RB1 OVEREXPRESSION
( ENST00000267163.6 )
D Predictive Supports Resistance Somatic 2 11792751 Detail
colorectal cancer SMAD4 LOSS
( ENST00000342988.8 ) SMAD4 LOSS
( ENST00000342988.8 )
B Predictive Supports Resistance N/A 3 12237773 Detail
esophagus squamous cell carcinoma AURKA EXPRESSION AURKA EXPRESSION B Predictive Supports Sensitivity/Response N/A 3 25924824 Detail
rectum cancer MTHFR p.Ala263Val (p.A263V)
( ENST00000376583.7, ENST00000376585.6, ENST00000376590.9, ENST00000376592.6, ENST00000423400.7, ENST00000641407.1, ENST00000641820.1 ) MTHFR p.Ala263Val (p.A263V)
( ENST00000376585.6, ENST00000376583.7, ENST00000376590.9, ENST00000376592.6, ENST00000423400.7, ENST00000641407.1, ENST00000641820.1 )
B Predictive Supports Sensitivity/Response Common Germline 4 26693073 Detail
cancer DPYD c.1905+1G>A
( ENST00000370192.8 ) DPYD c.1905+1G>A
( ENST00000370192.8 )
A Predictive Supports Adverse Response Common Germline 5 23988873 Detail
cancer DPYD p.Ile560Ser (p.I560S)
( ENST00000370192.8 ) DPYD p.Ile560Ser (p.I560S)
( ENST00000370192.8 )
A Predictive Supports Adverse Response Common Germline 5 23988873 Detail
cancer DPYD RS67376798 HOMOZYGOSITY DPYD RS67376798 HOMOZYGOSITY A Predictive Supports Adverse Response Common Germline 5 23988873 Detail
esophageal cancer GNAS p.Leu131= (p.L131=)
( ENST00000306090.12, ENST00000306120.4, ENST00000313949.11, ENST00000349036.9, ENST00000371075.7, ENST00000371098.6, ENST00000371100.9, ENST00000371102.8, ENST00000419558.7, ENST00000423897.7, ENST00000453292.7, ENST00000462499.6, ENST00000467227.6, ENST00000472183.6, ENST00000482112.6, ENST00000491348.5, ENST00000493744.5, ENST00000657090.1, ENST00000663479.2, ENST00000676826.2 ) GNAS p.Leu131= (p.L131=)
( ENST00000306090.12, ENST00000306120.4, ENST00000313949.11, ENST00000349036.9, ENST00000371075.7, ENST00000371098.6, ENST00000371100.9, ENST00000371102.8, ENST00000419558.7, ENST00000423897.7, ENST00000453292.7, ENST00000462499.6, ENST00000467227.6, ENST00000472183.6, ENST00000482112.6, ENST00000491348.5, ENST00000493744.5, ENST00000657090.1, ENST00000663479.2, ENST00000676826.2 )
B Predictive Supports Resistance Common Germline 4 19274060 Detail
colorectal adenocarcinoma ERBB2 p.Leu755Ser (p.L755S)
( ENST00000269571.10, ENST00000406381.6, ENST00000445658.6, ENST00000541774.5, ENST00000584450.5, ENST00000584601.5 ) ERBB2 p.Leu755Ser (p.L755S)
( ENST00000269571.10, ENST00000406381.6, ENST00000445658.6, ENST00000541774.5, ENST00000584450.5, ENST00000584601.5 )
C Predictive Does Not Support Sensitivity/Response Somatic 3 27626067 Detail
breast cancer PIK3CA MUTATION PIK3CA MUTATION B Predictive Does Not Support Sensitivity/Response Somatic 3 18371219 Detail
stomach cancer MTHFR p.Ala263Val (p.A263V)
( ENST00000376583.7, ENST00000376585.6, ENST00000376590.9, ENST00000376592.6, ENST00000423400.7, ENST00000641407.1, ENST00000641820.1 ) MTHFR p.Ala263Val (p.A263V)
( ENST00000376585.6, ENST00000376583.7, ENST00000376590.9, ENST00000376592.6, ENST00000423400.7, ENST00000641407.1, ENST00000641820.1 )
B Predictive Supports Sensitivity/Response Rare Germline 3 18704422 Detail
colorectal cancer TYMS 5' TANDEM REPEAT TYMS 5' TANDEM REPEAT B Predictive Supports Resistance Rare Germline 3 20628391 Detail
head and neck squamous cell carcinoma EGFR AMPLIFICATION
( ENST00000275493.7 ) EGFR AMPLIFICATION
( ENST00000275493.7 )
B Predictive Does Not Support Sensitivity/Response Somatic 4 21048039 Detail
head and neck squamous cell carcinoma DPYD EXON 11-19 DELETION
( ENST00000370192.8 ) DPYD EXON 11-19 DELETION
( ENST00000370192.8 )
C Predictive Supports Sensitivity/Response Somatic 4 31871216 Detail
colorectal cancer VEGFA UNDEREXPRESSION
( ENST00000372055.9 ) VEGFA UNDEREXPRESSION
( ENST00000372055.9 )
B Predictive Supports Sensitivity/Response N/A 2 25973082 Detail
colorectal cancer DKK1 NUCLEAR EXPRESSION DKK1 NUCLEAR EXPRESSION B Predictive Supports Resistance N/A 3 25788273 Detail
colorectal cancer CDKN1A EXPRESSION CDKN1A EXPRESSION B Predictive Supports Resistance N/A 3 24708484 Detail
colorectal cancer ALCAM EXPRESSION ALCAM EXPRESSION B Predictive Supports Resistance N/A 3 24708484 Detail
head and neck squamous cell carcinoma CDKN1B EXPRESSION CDKN1B EXPRESSION B Predictive Supports Sensitivity/Response N/A 2 24239278 Detail
colorectal cancer HSPA5 EXPRESSION HSPA5 EXPRESSION B Predictive Supports Sensitivity/Response N/A 4 23456958 Detail
Annotation
Description Associated Genes Associated Variants Sensitivity Supported Source Links
49 patients gastric cancer patients treated with a... HSPH1 HSPH1 NUCLEAR EXPRESSION HSPH1 NUCLEAR EXPRESSION Sensitivity true CIViC Evidence detail
329 consecutive patients with stage II–III colorec... HSPH1 HSPH1 T17 DELETION
( ENST00000320027.10 ) HSPH1 T17 DELETION
( ENST00000320027.10 )
Sensitivity true CIViC Evidence detail
In Capan-1 cell lines engineered to reduce pRB exp... RB1 RB1 OVEREXPRESSION
( ENST00000267163.6 ) RB1 OVEREXPRESSION
( ENST00000267163.6 )
Resitance or Non-Reponse true CIViC Evidence detail
A retrospective study with 202 colorectal cancer p... SMAD4 SMAD4 LOSS
( ENST00000342988.8 ) SMAD4 LOSS
( ENST00000342988.8 )
Resitance or Non-Reponse true CIViC Evidence detail
A retrospective study examining the expression of ... AURKA AURKA EXPRESSION AURKA EXPRESSION Sensitivity true CIViC Evidence detail
Patients with the wild type (C/C) MTHFR gene are 2... MTHFR MTHFR p.Ala263Val (p.A263V)
( ENST00000376583.7, ENST00000376585.6, ENST00000376590.9, ENST00000376592.6, ENST00000423400.7, ENST00000641407.1, ENST00000641820.1 ) MTHFR p.Ala263Val (p.A263V)
( ENST00000376585.6, ENST00000376583.7, ENST00000376590.9, ENST00000376592.6, ENST00000423400.7, ENST00000641407.1, ENST00000641820.1 )
Sensitivity true CIViC Evidence detail
The Clinical Pharmacogenomics Implementation Conso... DPYD DPYD c.1905+1G>A
( ENST00000370192.8 ) DPYD c.1905+1G>A
( ENST00000370192.8 )
Adverse Response true CIViC Evidence detail
The Clinical Pharmacogenomics Implementation Conso... DPYD DPYD p.Ile560Ser (p.I560S)
( ENST00000370192.8 ) DPYD p.Ile560Ser (p.I560S)
( ENST00000370192.8 )
Adverse Response true CIViC Evidence detail
The Clinical Pharmacogenomics Implementation Conso... DPYD DPYD RS67376798 HOMOZYGOSITY DPYD RS67376798 HOMOZYGOSITY Adverse Response true CIViC Evidence detail
Overall, 63% of the patients in the T-allele group... GNAS GNAS p.Leu131= (p.L131=)
( ENST00000306090.12, ENST00000306120.4, ENST00000313949.11, ENST00000349036.9, ENST00000371075.7, ENST00000371098.6, ENST00000371100.9, ENST00000371102.8, ENST00000419558.7, ENST00000423897.7, ENST00000453292.7, ENST00000462499.6, ENST00000467227.6, ENST00000472183.6, ENST00000482112.6, ENST00000491348.5, ENST00000493744.5, ENST00000657090.1, ENST00000663479.2, ENST00000676826.2 ) GNAS p.Leu131= (p.L131=)
( ENST00000306090.12, ENST00000306120.4, ENST00000313949.11, ENST00000349036.9, ENST00000371075.7, ENST00000371098.6, ENST00000371100.9, ENST00000371102.8, ENST00000419558.7, ENST00000423897.7, ENST00000453292.7, ENST00000462499.6, ENST00000467227.6, ENST00000472183.6, ENST00000482112.6, ENST00000491348.5, ENST00000493744.5, ENST00000657090.1, ENST00000663479.2, ENST00000676826.2 )
Resitance or Non-Reponse true CIViC Evidence detail
Patient was a 35 year old male who was treated wit... ERBB2 ERBB2 p.Leu755Ser (p.L755S)
( ENST00000269571.10, ENST00000406381.6, ENST00000445658.6, ENST00000541774.5, ENST00000584450.5, ENST00000584601.5 ) ERBB2 p.Leu755Ser (p.L755S)
( ENST00000269571.10, ENST00000406381.6, ENST00000445658.6, ENST00000541774.5, ENST00000584450.5, ENST00000584601.5 )
Sensitivity false CIViC Evidence detail
This study of 140 patients with stage II-III breas... PIK3CA PIK3CA MUTATION PIK3CA MUTATION Sensitivity false CIViC Evidence detail
The MTHFR C667T variant was associated with signif... MTHFR MTHFR p.Ala263Val (p.A263V)
( ENST00000376583.7, ENST00000376585.6, ENST00000376590.9, ENST00000376592.6, ENST00000423400.7, ENST00000641407.1, ENST00000641820.1 ) MTHFR p.Ala263Val (p.A263V)
( ENST00000376585.6, ENST00000376583.7, ENST00000376590.9, ENST00000376592.6, ENST00000423400.7, ENST00000641407.1, ENST00000641820.1 )
Sensitivity true CIViC Evidence detail
The TYMS 5' 3TPR germline variant was significantl... TYMS TYMS 5' TANDEM REPEAT TYMS 5' TANDEM REPEAT Resitance or Non-Reponse true CIViC Evidence detail
EGFR amplification was not a predictor of response... EGFR EGFR AMPLIFICATION
( ENST00000275493.7 ) EGFR AMPLIFICATION
( ENST00000275493.7 )
Sensitivity false CIViC Evidence detail
A 69 year old patient diagnosed with HNSCC present... DPYD DPYD EXON 11-19 DELETION
( ENST00000370192.8 ) DPYD EXON 11-19 DELETION
( ENST00000370192.8 )
Sensitivity true CIViC Evidence detail
Decreased peri- and post-therapeutic expression of... VEGFA VEGFA UNDEREXPRESSION
( ENST00000372055.9 ) VEGFA UNDEREXPRESSION
( ENST00000372055.9 )
Sensitivity true CIViC Evidence detail
Nuclear expression of DICKKOPF-1 was identified in... DKK1 DKK1 NUCLEAR EXPRESSION DKK1 NUCLEAR EXPRESSION Resitance or Non-Reponse true CIViC Evidence detail
112 patients with rectal cancer who received 5-FU ... CDKN1A CDKN1A EXPRESSION CDKN1A EXPRESSION Resitance or Non-Reponse true CIViC Evidence detail
112 patients with rectal cancer who received 5-FU ... ALCAM ALCAM EXPRESSION ALCAM EXPRESSION Resitance or Non-Reponse true CIViC Evidence detail
41 HNSSC were analyzed by IHC for expression of EG... CDKN1B CDKN1B EXPRESSION CDKN1B EXPRESSION Sensitivity true CIViC Evidence detail
Expression of GRP78 (HSPA5) in colorectal cancer p... HSPA5 HSPA5 EXPRESSION HSPA5 EXPRESSION Sensitivity true CIViC Evidence detail
NCT ID Status Phase Summary Start date Completion date
NCT04216290 Active, not recruiting Phase 2 A Study of Chemotherapy and Radiation Therapy Compared to Chemotherapy and Radiation Therapy Plus MEDI4736 (Durvalumab) Immunotherapy for Bladder Cancer Which Has Spread to the Lymph Nodes (The INSPIRE Study) March 17, 2021 June 30, 2026
NCT05009069 Active, not recruiting Phase 2 A Study of Atezolizumab With or Without Tiragolumab Following Neoadjuvant Chemoradiotherapy in Participants With Locally Advanced Rectal Cancer March 18, 2022 October 30, 2026
NCT04937738 Active, not recruiting Phase 2 Perioperative Chemotherapy in Gastric Cancer July 21, 2021 July 1, 2029
NCT04522336 Active, not recruiting Phase 1 Pembrolizumab and Chemoradiotherapy for the Treatment of Unresectable Gastroesophageal Cancer September 16, 2020 July 18, 2024
NCT03337087 Active, not recruiting Phase 1/Phase 2 Liposomal Irinotecan, Fluorouracil, Leucovorin Calcium, and Rucaparib in Treating Patients With Metastatic Pancreatic, Colorectal, Gastroesophageal, or Biliary Cancer November 2, 2018 August 9, 2025
NCT05330429 Active, not recruiting Phase 2 Study of Magrolimab Given Together With FOLFIRI/BEV in Patients With Previously Treated Advanced Inoperable Metastatic Colorectal Cancer (mCRC) July 8, 2022 November 2026
NCT03329248 Active, not recruiting Phase 1/Phase 2 QUILT-3.060: NANT Pancreatic Cancer Vaccine: Molecularly Informed Integrated Immunotherapy in Subjects With Pancreatic Cancer Who Have Progressed on or After Standard-of-care Therapy November 6, 2017 December 2020
NCT01013649 Active, not recruiting Phase 3 Gemcitabine Hydrochloride With or Without Erlotinib Hydrochloride Followed by the Same Chemotherapy Regimen With or Without Radiation Therapy and Capecitabine or Fluorouracil in Treating Patients With Pancreatic Cancer That Has Been Removed by Surgery April 5, 2010 February 13, 2025
NCT04164069 Active, not recruiting Phase 1 Dasatinib for the Prevention of Oxaliplatin-Induced Neuropathy in Patients With Metastatic Gastrointestinal Cancer Receiving FOLFOX Chemotherapy With or Without Bevacizumab September 2, 2020 December 31, 2023
NCT03193190 Active, not recruiting Phase 1/Phase 2 A Study of Multiple Immunotherapy-Based Treatment Combinations in Participants With Metastatic Pancreatic Ductal Adenocarcinoma (Morpheus-Pancreatic Cancer) July 5, 2017 October 31, 2026
NCT03143153 Active, not recruiting Phase 3 A Study to Evaluate Efficacy in Subjects With Esophageal Cancer Treated With Nivolumab and Ipilimumab or Nivolumab Combined With Fluorouracil Plus Cisplatin Versus Fluorouracil Plus Cisplatin June 29, 2017 January 13, 2025
NCT00980460 Active, not recruiting Phase 3 Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver Cancer September 14, 2009 March 5, 2025
NCT02912559 Active, not recruiting Phase 3 Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair October 16, 2017 April 2, 2025
NCT03929666 Active, not recruiting Phase 2 A Safety and Efficacy Study of ZW25 (Zanidatamab) Plus Combination Chemotherapy in HER2-expressing Gastrointestinal Cancers, Including Gastroesophageal Adenocarcinoma, Biliary Tract Cancer, and Colorectal Cancer August 29, 2019 October 30, 2026
NCT00873275 Active, not recruiting Phase 1 Ursodiol, Combination Chemotherapy, and Bevacizumab in Treating Patients With Stage IV Colorectal Cancer March 11, 2009 January 13, 2025
NCT02890355 Active, not recruiting Phase 2 FOLFIRI or Modified FOLFIRI and Veliparib as Second Line Therapy in Treating Patients With Metastatic Pancreatic Cancer September 1, 2016 March 5, 2025
NCT02872116 Active, not recruiting Phase 3 Efficacy Study of Nivolumab Plus Ipilimumab or Nivolumab Plus Chemotherapy Against Chemotherapy in Stomach Cancer or Stomach/Esophagus Junction Cancer October 12, 2016 May 31, 2024
NCT04481204 Active, not recruiting Phase 2 New and Emerging Therapies for the Treatment of Resectable, Borderline Resectable, or Locally Advanced Pancreatic Cancer, PIONEER-Panc Study April 18, 2023 April 6, 2025
NCT04094688 Active, not recruiting Phase 3 Vitamin D3 With Chemotherapy and Bevacizumab in Treating Patients With Advanced or Metastatic Colorectal Cancer September 30, 2019 July 2025
NCT04363801 Active, not recruiting Phase 2 A Study of DKN-01 in Combination With Tislelizumab ± Chemotherapy in Patients With Gastric or Gastroesophageal Cancer July 29, 2020 December 2025
NCT04068103 Active, not recruiting Phase 2/Phase 3 Circulating Tumor DNA Testing in Predicting Treatment for Patients With Stage IIA Colon Cancer After Surgery December 16, 2019 April 30, 2027
NCT03693807 Active, not recruiting Phase 2 A Study of the Use of the Medtronic Pump and Codman Catheter to Give Chemotherapy to Patients With Colorectal Carcinoma or Cholangiocarcinoma October 18, 2018 September 2024
NCT02688712 Active, not recruiting Phase 2 ExIST Study of LY2157299 (Galunisertib) in Rectal Cancer March 24, 2016 December 2025
NCT03586869 Active, not recruiting Phase 1/Phase 2 QUILT-3.080: NANT Pancreatic Cancer Vaccine July 28, 2018 December 2019
NCT02560298 Active, not recruiting Phase 2 Cisplatin and Fluorouracil Compared With Carboplatin and Paclitaxel in Treating Patients With Inoperable Locally Recurrent or Metastatic Anal Cancer August 23, 2016 August 2023
NCT00707473 Active, not recruiting Phase 2 Docetaxel, Cisplatin and Fluorouracil in Treating Patients With Previously Untreated Stage II-IV Nasal Cavity and Paranasal Sinus Cancer June 16, 2008 September 30, 2025
NCT04752696 Active, not recruiting Phase 2 Onvansertib in Combination With Nanoliposomal Irinotecan, Leucovorin, and Fluorouracil for Second-Line Treatment of Participants With Metastatic Pancreatic Ductal Adenocarcinoma February 3, 2021 March 11, 2024
NCT00588770 Active, not recruiting Phase 3 Chemotherapy With or Without Bevacizumab in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma August 8, 2008 February 22, 2025
NCT00544414 Active, not recruiting Phase 2 Chemotherapy Followed by Surgery, Chemotherapy, and Radiation Therapy in Treating Patients With Locally Advanced Head And Neck Cancer June 7, 2000 December 30, 2024
NCT03533582 Active, not recruiting Phase 2/Phase 3 Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery May 24, 2018 June 30, 2026
NCT04535401 Active, not recruiting Phase 1 Testing the Addition of an Anticancer Drug, BAY 1895344, to the Usual Chemotherapy With FOLFIRI in Advanced or Metastatic Cancers of the Stomach and Intestines August 13, 2021 April 29, 2025
NCT02419495 Active, not recruiting Phase 1 Phase IB Study to Evaluate the Safety of Selinexor (KPT-330) in Combination With Multiple Standard Chemotherapy or Immunotherapy Agents in Patients With Advanced Malignancies June 26, 2015 December 31, 2024
NCT02258659 Active, not recruiting Phase 2 Nab-paclitaxel and Carboplatin Followed by Response-Based Local Therapy in Treating Patients With Stage III or IV HPV-Related Oropharyngeal Cancer September 22, 2014 December 2025
NCT02135419 Active, not recruiting Phase 3 Treatment in Preventing Anal Cancer in Patients With HIV and Anal High-Grade Lesions September 24, 2014 March 31, 2024
NCT00492999 Active, not recruiting Phase 2 Hepatic Arterial Infusion With Floxuridine and Dexamethasone Combined With Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver May 2007 May 2025
NCT04523818 Active, not recruiting Phase 1 Short-Course Chemoradiotherapy Followed by Chemotherapy for the Treatment of Resectable Gastric Adenocarcinoma August 11, 2020 December 31, 2028
NCT05568095 Active, not recruiting Phase 3 A Clinical Trial of a New Combination Treatment, Domvanalimab and Zimberelimab, Plus Chemotherapy, for People With an Upper Gastrointestinal Tract Cancer That Cannot be Removed With Surgery That Has Spread to Other Parts of the Body November 21, 2022 May 2026
NCT00433420 Active, not recruiting Phase 3 Combination Chemotherapy With or Without Fluorouracil and/or Pegfilgrastim in Treating Women With Node-Positive Breast Cancer April 2003 December 2025
NCT02135042 Active, not recruiting Phase 2/Phase 3 Individualized Treatment in Treating Patients With Stage II-IVB Nasopharyngeal Cancer Based on EBV DNA April 21, 2014 February 2031
NCT00335816 Active, not recruiting Phase 2 Radiation Therapy and Fluorouracil With or Without Combination Chemotherapy Followed by Surgery in Treating Patients With Stage II or Stage III Rectal Cancer August 2008 December 2024
NCT03504397 Active, not recruiting Phase 3 A Phase 3 Efficacy, Safety and Tolerability Study of Zolbetuximab (Experimental Drug) Plus mFOLFOX6 Chemotherapy Compared to Placebo Plus mFOLFOX6 as Treatment for Gastric and Gastroesophageal Junction (GEJ) Cancer June 21, 2018 March 31, 2025
NCT00301925 Active, not recruiting Phase 3 Combination Chemotherapy in Treating Patients With Early Stage Breast Cancer That Has Been Removed By Surgery December 16, 2005 September 2024
NCT02059499 Active, not recruiting Phase 3 Imiquimod, Fluorouracil, or Observation in Treating HIV-Positive Patients With High-Grade Anal Squamous Skin Lesions December 28, 2015 May 21, 2024
NCT03387111 Active, not recruiting Phase 1/Phase 2 QUILT-3.090: NANT Squamous Cell Carcinoma (SCC) Vaccine: Subjects With SCC Who Have Progressed January 13, 2018 April 2021
NCT03837977 Active, not recruiting Phase 2 Second-line Therapy for Patients With Progressive Poorly Differentiated Extra-pulmonary Neuroendocrine Carcinoma November 13, 2018 December 1, 2023
NCT03776487 Active, not recruiting Phase 2 Nivolumab, Ipilimumab and Chemoradiation in Treating Patients With Resectable Gastric Cancer January 7, 2019 December 30, 2026
NCT02047474 Active, not recruiting Phase 2 Combination Chemotherapy Before and After Surgery in Treating Patients With Localized Pancreatic Cancer March 25, 2014 December 2026
NCT02037048 Active, not recruiting Phase 2 FOLFOX-6 Induction Chemotherapy Followed by Esophagectomy and Post-operative Chemoradiotherapy in Patients With Esophageal Adenocarcinoma February 10, 2014 October 1, 2025
NCT00217737 Active, not recruiting Phase 3 Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer September 6, 2005 September 30, 2024
NCT01871571 Active, not recruiting Phase 2 Bevacizumab, Fluorouracil, Leucovorin Calcium, and Oxaliplatin Before Surgery in Treating Patients With Stage II-III Rectal Cancer August 2, 2013 June 24, 2023
NCT01847326 Active, not recruiting Phase 1 Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Carboplatin Followed By Chemoradiation in Treating Patients With Recurrent Head and Neck Cancer March 26, 2013 November 4, 2027
NCT04761614 Active, not recruiting Phase 1 Riluzole in Combination With mFOLFOX6 and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer April 2, 2021 December 31, 2024
NCT00059930 Active, not recruiting Phase 1 Adjuvant Hepatic Arterial Infusion and Combination Chemotherapy in Treating Patients With Resectable Hepatic Metastases From Colorectal Cancer January 2003 June 2024
NCT03775265 Active, not recruiting Phase 3 Chemoradiotherapy With or Without Atezolizumab in Treating Patients With Localized Muscle Invasive Bladder Cancer June 3, 2019 June 1, 2027
NCT01154920 Active, not recruiting Phase 2 Paclitaxel, Carboplatin and Cetuximab (PCC) With Cetuximab, Docetaxel, Cisplatin and Fluorouracil (C-TPF) in Previously Untreated Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma July 9, 2010 December 31, 2025
NCT03773367 Active, not recruiting Phase 2 Irinotecan-based Triplet (FOLFOXIRI) as Perioperative Treatment in Resectable Gastric and Gastroesophageal Junction Adenocarcinoma. December 14, 2018 May 31, 2026
NCT04233866 Active, not recruiting Phase 2 Comparing Two Treatment Combinations, Gemcitabine and Nab-Paclitaxel With 5-Fluorouracil, Leucovorin, and Liposomal Irinotecan for Older Patients With Pancreatic Cancer That Has Spread August 26, 2020 December 31, 2025
NCT03736720 Active, not recruiting Phase 2 Liposomal Irinotecan, Fluorouracil and Leucovorin in Treating Patients With Refractory Advanced High Grade Neuroendocrine Cancer of Gastrointestinal, Unknown, or Pancreatic Origin June 17, 2019 June 17, 2026
NCT03340896 Active, not recruiting Phase 3 Trial of Laryngeal Preservation Comparing Induced CT Followed by RT vs CT Concomitant to RT June 25, 2015 November 2028
NCT03970252 Active, not recruiting Early Phase 1 Nivolumab in Combination With Chemotherapy Pre-Surgery in Treating Patients With Borderline Resectable Pancreatic Cancer July 24, 2019 April 2026
NCT02436044 Approved for marketing HAIC Using Oxaliplatin Plus Fluorouracil/Leucovorin for Patients With Locally Advanced HCC
NCT00003834 Completed Phase 2 Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal Cancer March 1999 December 2005
NCT00003835 Completed Phase 3 Combination Chemotherapy in Treating Patients With Stage III Colon Cancer May 1999
NCT00003862 Completed Phase 2 Chemotherapy and Radiation Therapy in Treating Patients With Stomach Cancer November 1999
NCT00003873 Completed Phase 3 Fluorouracil With or Without Eniluracil in Treating Patients With Advanced Colorectal Cancer April 1999
NCT00003888 Completed Phase 3 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Advanced Head and Neck Cancer April 1999 March 2015
NCT00003893 Completed Phase 3 Adjuvant Chemotherapy Plus Radiation Therapy in Treating Women With Early-Stage Breast Cancer July 1998 April 2006
NCT00003956 Completed Phase 1 Combination Chemotherapy in Treating Patients With Advanced Cancer April 1999 December 2009
NCT00003994 Completed Phase 3 Combination Chemotherapy With or Without Amifostine in Treating Young Patients With Liver Cancer March 1999
NCT00004003 Completed Phase 2 Combination Chemotherapy in Treating Patients With Stage III or Stage IV Pancreatic Cancer That Cannot Be Removed by Surgery April 1999 August 2003
NCT00004005 Completed Phase 2 Irinotecan Followed By Fluorouracil and Leucovorin in Treating Patients With Stage III or Stage IV Colorectal Carcinoma (Cancer), Other Refractory Carcinoma, or Metastatic Adenoma (Cancer) of Unknown Primary Origin September 1998 October 2005
NCT00004059 Completed Phase 1 Fluorouracil Plus UCN-01 in Treating Patients With Advanced or Refractory Solid Tumors July 1999 September 2002
NCT00004089 Completed Phase 2 Chemotherapy Plus Radiation Therapy in Treating Patients With Previously Untreated Thyroid Cancer August 1999 April 2002
NCT00004102 Completed Phase 2 Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer January 1999
NCT00004127 Completed Phase 2 Oxaliplatin Combined With Fluorouracil and Leucovorin in Treating Patients With Recurrent or Metastatic Cancer of the Esophagus or Stomach February 2000 August 2003
NCT00004150 Completed Phase 3 High-Dose Fluorouracil With or Without Leucovorin Compared With Standard Fluorouracil Plus Leucovorin Following Surgery in Treating Patients With Stage III Colon Cancer March 1999 April 2007
NCT00004233 Completed Phase 2 S9915 Triacetyluridine, Fluorouracil, and Leucovorin in Treating Patients With Unresectable, Locally Advanced, or Metastatic Cancer of the Esophagus or Stomach February 2001 January 2007
NCT00004242 Completed Phase 1 Combination Chemotherapy in Treating Patients With Metastatic or Unresectable Solid Tumors October 1999
NCT00004252 Completed Phase 3 Leucovorin and Fluorouracil With or Without SU5416 in Treating Patients With Metastatic Colorectal Cancer November 1999 September 2007
NCT00004257 Completed Phase 1 Oxaliplatin and Fluorouracil Plus Radiation Therapy in Treating Patients With Primary Esophageal or Stomach Cancer January 2000 January 2004
NCT00004865 Completed Phase 2 Cetuximab Plus Cisplatin in Treating Patients With Metastatic or Recurrent Cancer of the Head and Neck That Has Not Responded to Cisplatin Chemotherapy November 1999
NCT00004873 Completed Phase 2 Combination Chemotherapy in Treating Patients With Advanced Stomach Cancer August 1999 July 2003
NCT00004885 Completed Phase 3 Fluorouracil and Leucovorin With or Without Irinotecan in Treating Patients With Metastatic Colorectal Cancer July 1999
NCT00004901 Completed Phase 1/Phase 2 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Advanced Mouth Cancer October 1999 July 2004
NCT00004913 Completed Phase 1 Combination Chemotherapy in Treating Patients With Advanced Solid Tumors January 2000 May 2002
NCT00004931 Completed Phase 3 Fluorouracil Plus Leucovorin With or Without Oxaliplatin in Treating Patients With Stage II or Stage III Colon Cancer February 2000
NCT00005036 Completed Phase 3 Irinotecan Compared With Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer November 1999
NCT00005050 Completed Phase 1/Phase 2 Eniluracil, Fluorouracil, and Oxaliplatin in Treating Patients With Advanced Colorectal Cancer August 1999
NCT00005068 Completed Phase 1 Combination Chemotherapy In Treating Patients With Metastatic or Unresectable Solid Tumors January 2000 June 2003
NCT00005586 Completed Phase 3 Leucovorin and Fluorouracil Compared With Observation in Treating Patients With Colorectal Cancer That Has Been Surgically Removed October 1997
NCT00005791 Completed Phase 1 Combination Chemotherapy in Treating Patients With Locally Advanced or Metastatic Solid Tumors October 1999 December 2009
NCT00005979 Completed Phase 3 Combination Chemotherapy With or Without Irinotecan in Treating Patients With Stage III Colon Cancer July 22, 1998 September 1, 2007
NCT00006038 Completed Phase 2 Combination Chemotherapy Followed by Surgery and Intraperitoneal Chemotherapy in Treating Patients With Locally Advanced Stomach Cancer February 2000 February 2003
NCT00006050 Completed Phase 2 Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver April 4, 1999 April 4, 2003
NCT00006051 Completed Phase 2 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Head and Neck Cancer February 1999 September 2005
NCT00006094 Completed Phase 1/Phase 2 Oxaliplatin, Fluorouracil, and External-Beam Radiation Therapy Followed by Surgery in Treating Patients With Locally Advanced Cancer of the Rectum July 2000
NCT00006103 Completed Phase 3 Combination Chemotherapy in Treating Patients With Colorectal Cancer July 2000 April 2002
NCT00006111 Completed Phase 2 Surgery Plus Combination Chemotherapy and Radiation Therapy in Treating Patients With Cancer of the Urinary Tract April 1999 June 2008
NCT00006248 Completed Phase 2 S0007 - Combination Chemotherapy in Treating Patients With Metastatic or Recurrent Head and Neck Cancer November 2000 June 2005
NCT00006366 Completed Phase 2 Radiation Therapy Plus Chemotherapy Followed by Surgery in Treating Patients With Locally Advanced Cancer of the Rectum February 2001
NCT00006786 Completed Phase 2 Combination Chemotherapy Plus Bevacizumab in Treating Patients With Advanced Colorectal Cancer November 2000 September 2006
NCT00007878 Completed Phase 1 Bortezomib, Fluorouracil, and Leucovorin Calcium in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed By Surgery September 2000
NCT00008060 Completed Phase 3 Combination Chemotherapy in Treating Patients With Unresectable Metastatic Colorectal Cancer May 2000 December 2003
NCT00008294 Completed Phase 1 Combination Chemotherapy in Treating Patients With Unresectable Liver Metastases From Colorectal Cancer August 2000
NCT00009880 Completed Phase 2 Combination Chemotherapy Plus Radiation Therapy With or Without Fluorouracil in Treating Patients With Cancer of the Esophagus or Stomach April 2001
NCT00009893 Completed Phase 2 Combination Chemotherapy in Treating Patients With Unresectable or Metastatic Biliary Tract or Gallbladder Cancer May 2001 October 2009
NCT00014222 Completed Phase 3 Combination Chemotherapy With or Without Colony-stimulating Factors in Treating Women With Breast Cancer December 4, 2000 March 17, 2014
NCT00015886 Completed Phase 2 Combination Chemotherapy in Treating Women With Breast Cancer That is Metastatic or Cannot be Treated With Surgery January 1997 July 2009
NCT00016133 Completed Phase 1/Phase 2 Vaccine Therapy in Treating Patients With Stage II or Stage III Colon Cancer That Has Been Removed During Surgery March 2001 August 2004
NCT00016198 Completed Phase 2 Fluorouracil and Leucovorin With or Without Oxaliplatin in Treating Patients With Recurrent Metastatic Colorectal Cancer May 2001 December 2010
NCT00016952 Completed Phase 2 Irinotecan or Fluorouracil Plus Leucovorin in Treating Patients With Previously Treated Metastatic Colorectal Cancer April 2001 October 2009
NCT00016978 Completed Phase 2 Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer Previously Treated With Irinotecan April 2001
NCT00017095 Completed Phase 3 Biomarker (p53 Gene) Analysis and Combination Chemotherapy Followed by Radiation Therapy and Surgery in Treating Women With Large Operable or Locally Advanced or Inflammatory Breast Cancer March 2001
NCT00019474 Completed Phase 2 Combination Chemotherapy Plus Interferon Alfa Followed by Filgrastim in Treating Patients With Gastrointestinal Tract Cancer March 1998 August 2000
NCT00019513 Completed Phase 1 Combination Chemotherapy in Treating Patients With Recurrent, Refractory, or Metastatic Solid Tumors or Lymphomas August 1998 June 2004
NCT00020345 Completed Phase 2 Combination Chemotherapy and Radiation Therapy Plus Surgery in Treating Patients With Advanced Cancer of the Pancreas September 2000 March 2002
NCT00020488 Completed Phase 1 Combination Chemotherapy in Treating Patients Who Have Advanced Solid Tumors February 2001
NCT00020501 Completed Phase 3 Chemotherapy With or Without Isolated Hepatic Perfusion With Melphalan in Treating Patients With Colorectal Cancer That Has Spread to the Liver March 2001 January 2005
NCT00020787 Completed Phase 3 Vaccine Therapy Plus Chemotherapy in Treating Patients With Metastatic or Locally Recurrent Stomach Cancer or Esophageal Cancer July 2001 December 2002
NCT00020917 Completed Phase 2 Cetuximab Plus Combination Chemotherapy in Treating Patients With Stage IV Colorectal Cancer February 2001 February 2004
NCT00021073 Completed Phase 1 Combination Chemotherapy in Treating Patients With Advanced Cancer May 2001
NCT00021320 Completed Phase 2 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Esophageal Cancer May 2000 April 2009
NCT00021398 Completed Phase 2 Radiation Therapy and Chemotherapy Followed by Surgery and Combination Chemotherapy in Treating Patients With Rectal Cancer July 1996 September 2018
NCT00022139 Completed Phase 2 Radiation Therapy and Paclitaxel, Carboplatin, and Fluorouracil Followed by Esophagectomy in Treating Patients With Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction January 2002 January 2009
NCT00023660 Completed Phase 1/Phase 2 Radiation Therapy Plus Celecoxib, Fluorouracil, and Cisplatin in Patients With Locally Advanced Cervical Cancer August 2001
NCT00023751 Completed Phase 2 Surgery With or Without Chemotherapy and Radiation Therapy in TreatingPatients With Stage I Rectal Cancer July 2001 April 2004
NCT00023959 Completed Phase 1 Bevacizumab, Fluorouracil, and Hydroxyurea Plus Radiation Therapy in Treating Patients With Advanced Head and Neck Cancer July 2001
NCT00024141 Completed Phase 1 Irinotecan Followed by Fluorouracil in Treating Patients With Advanced Solid Tumors May 2001 January 2003
NCT00024349 Completed Phase 3 Radiation Therapy With or Without Chemotherapy in Treating Patients With Stage II or Stage III Bladder Cancer June 2001 April 2012
NCT00024427 Completed Phase 3 Triacetyluridine and Fluorouracil Compared With Gemcitabine in Treating Patients With Unresectable Locally Advanced, or Metastatic Pancreatic Cancer February 2001
NCT00025090 Completed Phase 3 Radiation Therapy Plus Fluorouracil With or Without Additional Chemotherapy in Treating Patients With Primary Anal Cancer March 2001 August 2007
NCT00025142 Completed Phase 2 Gefitinib and Combination Chemotherapy in Treating Patients With Advanced Solid Tumors or Colorectal Cancer July 2001 November 2006
NCT00025337 Completed Phase 3 Combination Chemotherapy With or Without Bevacizumab Compared With Bevacizumab Alone in Treating Patients With Advanced or Metastatic Colorectal Cancer That Has Been Previously Treated September 2001
NCT00026130 Completed Phase 2 Combination Chemotherapy and Radiation Therapy in Treating Patients With Pancreatic Cancer September 2001 June 2010
NCT00026273 Completed Phase 3 Fluorouracil and Leucovorin With or Without Irinotecan in Treating Patients Following Surgery for Stage III Colorectal Cancer January 2001
NCT00026364 Completed Phase 1 ZD 1839 Plus Combination Chemotherapy in Treating Patients With Locally Advanced, Locally Recurrent, or Metastatic Colorectal Cancer November 2001
NCT00030342 Completed Phase 1/Phase 2 Biological Therapy and Chemotherapy in Treating Patients With Metastatic Kidney Cancer or Colorectal Cancer November 2001 January 2008
NCT00033735 Completed Phase 3 Irofulven Compared With Fluorouracil in Treating Patients With Pancreatic Cancer January 2000
NCT00036868 Completed Phase 2 Combination Chemotherapy With Trastuzumab in Treating Women With Metastatic Breast Cancer February 2002 February 2010
NCT00038402 Completed Phase 3 Evaluation of the Addition of Herceptin to Standard Chemotherapy in the Neoadjuvant Setting for Operable Breast Cancer April 2001 July 2011
NCT00039208 Completed Phase 2 Combination Chemotherapy in Treating Patients With Colorectal Cancer February 2002
NCT00039611 Completed N/A Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer May 2002 October 2007
NCT00042861 Completed Phase 1 UCN-01, Fluorouracil, and Leucovorin in Treating Patients With Metastatic or Unresectable Solid Tumors August 2002
NCT00042874 Completed Phase 1 Combination Chemotherapy in Treating Patients With Locally Advanced or Metastatic Solid Tumors May 2002
NCT00043121 Completed Phase 1 Combination Chemotherapy in Treating Patients With Advanced Cancer That is Metastatic or Cannot Be Removed By Surgery June 2002
NCT00045747 Completed Phase 2 UCN-01 and Fluorouracil in Treating Patients With Metastatic Pancreatic Cancer July 2002 September 2004
NCT00047099 Completed Phase 3 Combination Chemotherapy in Treating Women With Breast Cancer August 2001 March 2012
NCT00047112 Completed Phase 3 Surgery With or Without Radiation Therapy and Chemotherapy in Treating Patients With Esophageal Cancer May 2002 September 2010
NCT00049101 Completed Phase 1/Phase 2 Erlotinib and Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer August 2002 August 2004
NCT00049348 Completed Phase 2 Chemotherapy and Radiation Therapy in Treating Patients With Locally Advanced Pancreatic Cancer October 13, 2003 May 2009
NCT00052429 Completed Phase 1/Phase 2 High-Dose Radiation Therapy Plus Chemotherapy in Treating Patients With Advanced Nose or Throat Cancer September 2002 November 2010
NCT00052559 Completed Phase 1 Bevacizumab, Fluorouracil, and External-Beam Radiation Therapy in Treating Patients With Stage II or Stage III Rectal Cancer August 2002
NCT00052910 Completed Phase 3 Chemotherapy and Radiation Therapy After Surgery in Treating Patients With Stomach or Esophageal Cancer December 2002 December 2016
NCT00053807 Completed Phase 3 Interleukin-2, Interferon Alfa, and Fluorouracil Compared With Observation in Treating Patients Who Have Undergone Surgery for Kidney Cancer February 1998
NCT00053820 Completed Phase 3 Interferon Alfa With or Without Interleukin-2 and Fluorouracil in Treating Patients With Advanced Metastatic Kidney Cancer July 2002 December 2006
NCT00054054 Completed Phase 2 S0216, Combination Chemotherapy and RT in Treating Patients With Stage III or Stage IV Head and Neck Cancer April 2003
NCT00054587 Completed Phase 3 Combination Chemotherapy With or Without Trastuzumab in Treating Women With Breast Cancer June 2001 December 2009
NCT00055601 Completed Phase 2 Combination Chemotherapy and Radiation Therapy With/Without Surgery In Patients With Stage II/III Bladder Cancer December 2002 May 14, 2018
NCT00055679 Completed Phase 3 Combination Chemotherapy in Treating Women With Stage I Breast Cancer August 2002 June 2013
NCT00055822 Completed Phase 1/Phase 2 Combination Chemotherapy and Oblimersen in Treating Patients With Advanced Colorectal Cancer October 2002 October 2004
NCT00056030 Completed Phase 2 Combination Chemotherapy Plus Cetuximab in Treating Patients With Liver Metastases From Colorectal Cancer December 2004
NCT00057785 Completed Phase 2 Radiation Therapy With or Without Chemotherapy in Reducing Mouth Dryness in Patients With Nasopharyngeal Cancer February 2003 December 2016
NCT00058201 Completed Phase 3 Two Chemotherapy Regimens Compared With Observation in Treating Patients With Completely Resected Pancreatic Cancer July 2001 September 2010
NCT00000758 Completed Phase 3 A Phase III Randomized Trial of Topical Vaginal Fluorouracil (5-Fluorouracil, 5-FU) Maintenance Therapy Versus Observation After Standard Treatment for High-Grade Cervical Dysplasia in HIV-Infected Women April 1998
NCT00002470 Completed Phase 2 Fluorouracil Plus Interferon Alfa in Treating Patients With Advanced Metastatic Carcinoid Tumors September 1990 January 2004
NCT00002476 Completed Phase 3 Radiation Therapy With or Without Chemotherapy in Treating Patients With Advanced Head and Neck Cancer January 1990 January 2010
NCT00002496 Completed Phase 3 Radiation Therapy With or Without Chemotherapy in Treating Patients With Advanced Cancer of the Larynx August 1992 November 2013
NCT00002523 Completed Phase 3 Radiation Therapy, Surgery, and Chemotherapy in Treating Patients With Rectal Cancer That Can Be Surgically Removed April 1993 January 2016
NCT00002524 Completed Phase 2 Combination Chemotherapy in Treating Patients With AIDS-Related Lymphoma June 1993 October 2005
NCT00002542 Completed Phase 3 Tamoxifen in Treating Women With High-Risk Breast Cancer July 20, 1993 January 11, 2011
NCT00002551 Completed Phase 3 SWOG-9304 Chemotherapy Plus Radiation Therapy in Treating Patients With Rectal Cancer That Has Been Surgically Removed March 1994 October 2008
NCT00002570 Completed Phase 3 Immediate Compared With Delayed Chemotherapy in Advanced Colorectal Cancer Without Signs or Symptoms of Disease July 15, 1994 February 10, 2009
NCT00002579 Completed Phase 3 Tamoxifen Following Combination Chemotherapy in Treating Women With Operable Invasive Breast Cancer March 1993
NCT00002580 Completed Phase 3 Tamoxifen, Ovarian Ablation, and/or Combination Chemotherapy in Treating Premenopausal Women With Stage I, Stage II, or Stage IIIA Invasive Breast Cancer June 1993
NCT00002581 Completed Phase 3 Tamoxifen With or Without Combination Chemotherapy in Treating Postmenopausal Women With Operable Invasive Breast Cancer June 1993
NCT00002582 Completed Phase 3 Tamoxifen, Ovarian Ablation, and/or Chemotherapy in Treating Women With Stage I, Stage II, or Stage IIIA Breast Cancer June 1993 April 2007
NCT00002593 Completed Phase 3 S9415 Chemotherapy in Patients With Stage II or III Colon Cancer That Has Been Surgically Removed December 1994 March 2005
NCT00002615 Completed Phase 3 Surgery With or Without Combination Chemotherapy in Treating Patients With Stomach Cancer June 1994 December 2003
NCT00002631 Completed Phase 3 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Cancer of the Esophagus June 1995
NCT00002689 Completed Phase 2 Radiation Therapy Plus Chemotherapy in Treating Patients With Pancreatic Cancer September 1995 June 2007
NCT00002716 Completed Phase 3 Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal Cancer January 1996 August 2006
NCT00002722 Completed Phase 2 High-Dose Chemotherapy in Treating Patients With Advanced Stomach Cancer January 1996
NCT00002755 Completed Phase 3 Standard Chemotherapy Compared With High-Dose Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Women With Breast Cancer November 1995 June 1999
NCT00002783 Completed Phase 2 Combination Chemotherapy Before and After Surgery in Treating Patients With Stomach Cancer May 1996 January 2001
NCT00002784 Completed Phase 3 High-Dose Combination Chemotherapy Plus Peripheral Stem Cell Transplantation Compared With Standard Combination Chemotherapy in Treating Women With High-Risk Breast Cancer June 1996 December 2011
NCT00002828 Completed Phase 1 Chemotherapy With Raltitrexed and Fluorouracil in Treating Patients With Advanced Colorectal Cancer April 1995 November 2001
NCT00002839 Completed Phase 3 Combination Chemotherapy Plus Radiation Therapy To Preserve the Larynx in Patients With Cancer of the Hypopharynx or Larynx July 1996
NCT00002842 Completed Phase 2 Liver Resection and Floxuridine Plus Fluorouracil and Leucovorin in Treating Patients With Liver Metastases From Colorectal Cancer September 1994 May 2014
NCT00002870 Completed Phase 3 High Dose Chemotherapy Plus Peripheral Stem Cell Transplantation Compared With Standard Therapy in Treating Women With Locally Recurrent or Metastatic Breast Cancer December 1994 January 2002
NCT00002883 Completed Phase 3 Surgery With or Without Combination Chemotherapy in Treating Patients With Cancer of the Esophagus October 1996 August 2010
NCT00002888 Completed Phase 3 Combination Chemotherapy in Treating Patients With Advanced Head and Neck Cancer March 1997 August 2004
NCT00002897 Completed Phase 3 Surgery With or Without Chemotherapy in Treating Patients With Stage II or Stage III Cancer of the Esophagus July 1992 June 2001
NCT00002951 Completed Phase 2 Chemotherapy Plus Radiation Therapy in Treating Patients With Head and Neck Cancer June 1996 July 2006
NCT00002955 Completed Phase 2 Combination Chemotherapy in Treating Patients With Advanced Cancer of the Pancreas August 1995 June 2006
NCT00002984 Completed Phase 1/Phase 2 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Advanced or Metastatic Cancer of the Esophagus March 1997 January 2007
NCT00003012 Completed Phase 3 Combination Chemotherapy Following Surgery in Treating Women With Early Stage Breast Cancer October 1996
NCT00003013 Completed Phase 3 Chemotherapy Plus Surgery in Treating Women With Breast Cancer October 1996 March 2009
NCT00003018 Completed Phase 2 S9700 Combination Chemotherapy in Treating Patients With Stage II or Stage III Pancreatic Cancer September 1997 January 2007
NCT00003029 Completed Phase 3 Fluorouracil With or Without Cisplatin in Treating Patients With Advanced or Metastatic Cancer of the Pancreas May 1997
NCT00003049 Completed Phase 3 Surgery Followed by Radiation Therapy and Chemotherapy in Treating Patients With Cancer of the Pancreas May 1997 July 2007
NCT00003078 Completed Phase 3 Radiation Therapy With or Without Cisplatin or Fluorouracil in Treating Patients With Cancer of the Cervix October 1997
NCT00003118 Completed Phase 3 Surgery With or Without Chemotherapy and Radiation Therapy in Treating Patients With Cancer of the Esophagus October 1997 March 2000
NCT00003172 Completed Phase 2 Comparison of Combination Chemotherapy Regimens in Treating Patients With Advanced Stomach Cancer December 1997 September 2004
NCT00003175 Completed Phase 2 Fluorouracil in Treating Patients With Recurrent or Metastatic Bladder Cancer December 1997 March 2009
NCT00003209 Completed Phase 3 Radiation Therapy With or Without Chemotherapy After Surgery in Treating Patients With Stage IB or Stage IIA Cervical Cancer December 1997
NCT00003216 Completed Phase 3 Fluorouracil, Gemcitabine, and Radiation Therapy in Treating Patients With Cancer of the Pancreas July 1998
NCT00003254 Completed Phase 2 SWOG-S9635 Fluorouracil Plus Ethynyluracil in Advanced Colorectal Cancer Not Responded to Fluorouracil April 1998 October 2003
NCT00003287 Completed Phase 3 Combination Chemotherapy in Treating Patients With Recurrent or Metastatic Colorectal Cancer March 1998
NCT00003298 Completed Phase 2 Chemotherapy, Surgery, and Radiation Therapy in Treating Patients With Gastric Cancer June 1, 1999 May 2011
NCT00003331 Completed Phase 1 Combination Chemotherapy in Treating Patients With Advanced Cancer January 1998
NCT00003422 Completed Phase 3 Radiation Therapy Before Surgery Compared With Chemotherapy Plus Radiation After Surgery in Treating Patients With Rectal Cancer That Can Be Surgically Removed January 1998 June 2010
NCT00003446 Completed Phase 2 Chemotherapy in Treating Patients With Recurrent or Metastatic Colorectal Cancer December 1997 August 2005
NCT00003543 Completed Phase 1 Monoclonal Antibody Therapy Plus Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer June 1998 August 2002
NCT00003549 Completed Phase 2 S9716: Combination Chemotherapy in Treating Patients With Merkel Cell Cancer October 1998 January 2003
NCT00003576 Completed Phase 3 Surgery and Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Stage III or Stage IV Head and Neck Cancer That Can Be Removed During Surgery January 1997 August 2005
NCT00003577 Completed Phase 3 Combination Chemotherapy With or Without Epirubicin in Treating Women With Stage I or Stage II Breast Cancer March 1996 September 2008
NCT00003582 Completed Phase 1/Phase 2 Radiation Therapy, Combination Chemotherapy, and Amifostine in Treating Patients With Head and Neck Cancer May 1988 December 1996
NCT00003585 Completed Phase 1/Phase 2 Biological Therapy Plus Chemotherapy in Treating Patients With Metastatic or Recurrent Kidney Cancer August 1996 August 2002
NCT00003594 Completed Phase 3 Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer October 1998 October 2004
NCT00003596 Completed Phase 3 Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer October 1998 December 2016
NCT00003627 Completed Phase 3 Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Advanced Cancer of the Oropharynx or Hypopharynx October 1998 January 2011
NCT00003652 Completed Phase 3 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer January 4, 1999 March 31, 2007
NCT00003730 Completed N/A Vinorelbine Plus Fluorouracil in Treating Women With Metastatic Breast Cancer December 1998
NCT00003799 Completed Phase 1 Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Locally Advanced Rectal Cancer May 1999
NCT00060411 Completed Phase 1 A Phase I, Pharmacological, and Biological Study of OSI-774 in Combination With FOLFOX 4 (5-FU, Leucovorin, and Oxaliplatin) and Bevacizumab (Avastin) in Patients With Advanced Colorectal Cancer June 2003
NCT00062426 Completed Phase 3 Oxaliplatin and Bevacizumab (Avastin™) With Either Fluorouracil and Leucovorin or Capecitabine in Treating Patients With Advanced Colorectal Cancer May 2003 February 2011
NCT00064181 Completed Phase 3 Combination Chemotherapy With or Without Celecoxib in Treating Patients With Metastatic Colorectal Cancer May 2003
NCT00066274 Completed Phase 2 Comparison of Combination Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer July 23, 2002 April 1, 2007
NCT00066846 Completed Phase 2 Bevacizumab Plus Fluorouracil and Leucovorin in Treating Patients With Locally Advanced or Metastatic Stage IV Colorectal Cancer That Has Progressed After Standard Chemotherapy August 2003 July 2007
NCT00068575 Completed Phase 2 Chemotherapy, Interferon Alfa, and Radiation Therapy in Treating Patients Who Have Undergone Surgery For Pancreatic Cancer May 2002 December 2010
NCT00068692 Completed Phase 3 Comparison of Adjuvant Chemotherapy Regimens in Treating Stage II/III Rectal Cancer October 15, 2003 November 15, 2016
NCT00069953 Completed Phase 2 Combination Chemotherapy Followed By Chemoradiotherapy, With or Without Surgery, in Treating Patients With Resectable Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction September 2003 December 2016
NCT00070213 Completed Phase 3 Leucovorin and Fluorouracil With or Without Oxaliplatin Compared to Capecitabine With or Without Oxaliplatin in Treating Patients With Metastatic Colorectal Cancer September 2003 June 1, 2011
NCT00079274 Completed Phase 3 Comparison of Combination Chemotherapy Regimens With or Without Cetuximab in Treating Patients Who Have Undergone Surgery For Stage III Colon Cancer February 2004 November 2012
NCT00080951 Completed Phase 2 Irinotecan, Fluorouracil, Leucovorin, and Oxaliplatin as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer March 2004 February 2008
NCT00080990 Completed Phase 1 Alvocidib, Oxaliplatin, Fluorouracil, and Leucovorin Calcium in Treating Patients With Advanced Solid Tumors February 2004
NCT00081289 Completed Phase 2 Neoadjuvant Chemoradiotherapy and Adjuvant Chemotherapy in Treating Patients Who Are Undergoing Surgical Resection for Locally Advanced Rectal Cancer March 2004 December 2016
NCT00083109 Completed Phase 1/Phase 2 Fluorouracil and Low-Dose Suramin as Chemosensitization in Treating Patients With Metastatic Renal Cell (Kidney) Cancer March 2004 March 2008
NCT00084773 Completed N/A Neoadjuvant Cetuximab, Fluorouracil, and Pelvic Irradiation in Treating Patients With Locally Advanced or Locally Recurrent Rectal Cancer March 2004 March 2010
NCT00085163 Completed Phase 3 Celecoxib Combined With Fluorouracil and Leucovorin in Treating Patients With Resected Stage III Adenocarcinoma (Cancer) of the Colon March 2004
NCT00086996 Completed Phase 2 S0356 Oxaliplatin, 5-FU, Radiation Therapy (RT), Surgery for Pts With Stage II or III Cancer of Esophagus or Gastroesophageal (GE) Junction September 2004 August 2011
NCT00087178 Completed Phase 3 Comparison of Two Combination Chemotherapy Regimens in Treating Women With Breast Cancer May 2004 May 2016
NCT00089024 Completed Phase 2 Combination Chemotherapy, and Radiation Therapy in Treating Patients With Locally Advanced Pancreatic Cancer February 25, 2004 December 1, 2014
NCT00095875 Completed Phase 3 Combination Chemotherapy and Radiation in Treating Patients With Stage III or IV Head and Neck Cancer (Paradigm Trial) August 2004 April 2012
NCT00096070 Completed Phase 2 Radiotherapy Combined With Oxaliplatin and Fluorouracil Followed By Gemcitabine in Treating Patients With Locally Advanced, Unresectable Pancreatic Cancer December 2004
NCT00096278 Completed Phase 3 Fluorouracil, Leucovorin, and Oxaliplatin With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II or Stage III Colon Cancer September 15, 2004 December 31, 2012
NCT00098787 Completed Phase 2 Bevacizumab and Oxaliplatin Combined With Irinotecan or Leucovorin and Fluorouracil in Treating Patients With Metastatic or Recurrent Colorectal Cancer September 8, 2005 April 2015
NCT00098982 Completed Phase 1 Bortezomib, Fluorouracil, Leucovorin, and Oxaliplatin in Treating Patients With Advanced or Metastatic Colorectal Cancer September 2004
NCT00100841 Completed Phase 2 Phase II Trial of FOLFOX6, Bevacizumab and Cetuximab in Patients With Colorectal Cancer November 2004 July 2011
NCT00103298 Completed Phase 2 Isolated Hepatic Perfusion With Melphalan Followed by Combination Chemotherapy in Treating Patients With Unresectable Liver Metastases From Colorectal Cancer December 2004 July 2006
NCT00112658 Completed Phase 2/Phase 3 Combination Chemotherapy as First-Line Therapy in Treating Patients With Metastatic Pancreatic Cancer November 2004 June 30, 2010
NCT00112697 Completed Phase 2 Radiation Therapy and Docetaxel With Either Fluorouracil or Cisplatin as First-Line Therapy in Treating Patients With Metastatic Pancreatic Cancer That Cannot Be Removed By Surgery October 6, 2003 March 1, 2012
NCT00117572 Completed Phase 3 Docetaxel Based Chemotherapy Plus or Minus Induction Chemotherapy to Decrease Events in Head and Neck Cancer (DeCIDE) November 2004 December 2016
NCT00118261 Completed Phase 1 Erlotinib, Modified FOLFOX6, and Bevacizumab as First-Line Therapy Metastatic Colorectal Cancer March 2005 January 2011
NCT00129389 Completed Phase 3 FAC Versus FAC Plus Weekly Paclitaxel as Adjuvant Treatment of Node Negative High Risk Breast Cancer Patients September 19, 2003 October 1, 2013
NCT00129922 Completed Phase 3 Fluorouracil, Epirubicin, and Cyclophosphamide Alone or Followed by Paclitaxel for Early Breast Cancer November 1999 December 2007
NCT00138177 Completed Phase 1 Suberoylanilide Hydroxamic Acid, Fluorouracil, Leucovorin, and Oxaliplatin in Treating Patients With Progressive Metastatic or Unresectable Colorectal Cancer or Other Solid Tumors July 2005
NCT00193284 Completed Phase 2 Chemotherapy Plus Gefitinib Followed by Chemotherapy, Radiation Therapy, and Gefitinib For Head and Neck Cancer October 2003 January 2009
NCT00209625 Completed Phase 1/Phase 2 Phase I / II Study of Irinotecan (CPT-11) Combined With l-Leucovorin (l-LV) and 5-FU in Patients With Advanced Colorectal Cancer April 2000 November 2004
NCT00252564 Completed Phase 3 Cetuximab, Bevacizumab & 5FU/Leucovorin vs. Oxaliplatin, Bevacizumab & 5FU/Leucovorin in Metastatic Colorectal Cancer September 2005 June 2009
NCT00258323 Completed Phase 2 Radiotherapy,Chemotherapy,Before and After Surgery in Advanced Esophageal or Gastroesophageal Junction Cancer October 2005 February 2010
NCT00262808 Completed Phase 2 GM-CSF and Combination Chemotherapy in Treating Patients Who Are Undergoing Surgery for Stage II or Stage III Colon Cancer March 2004 September 2006
NCT00268333 Completed Phase 2 Combination Chemotherapy and Radiation Therapy in Treating Patients With Recurrent Metastatic Colorectal Cancer August 2005
NCT00274937 Completed Phase 3 Radiation Therapy, Amifostine, and Chemotherapy in Treating Young Patients With Newly Diagnosed Nasopharyngeal Cancer February 20, 2006 September 30, 2022
NCT00280176 Completed Phase 1 Bortezomib, Fluorouracil, and External-Beam Radiation Therapy in Treating Patients With Stage II, Stage III, or Stage IV Rectal Cancer April 2003 September 2010
NCT00281944 Completed Phase 1 Combination Chemotherapy in Treating Young Patients With Advanced Solid Tumors September 2005
NCT00296608 Completed Phase 3 Radiation Therapy With or Without Chemotherapy Before Surgery in Treating Patients With Stage II or Stage III Rectal Cancer April 1993 August 2008
NCT00303758 Completed Phase 3 Combination Chemotherapy in Treating Patients With Metastatic Pancreatic Cancer That Cannot Be Removed By Surgery October 2005 March 2012
NCT00303771 Completed Phase 3 Combination Chemotherapy as First-Line Therapy in Treating Older Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery June 2003 January 2011
NCT00309543 Completed Phase 3 Randomized Trial on Adjuvant Chemotherapy in Colon Carcinoma Dukes B November 1993
NCT00309569 Completed Phase 3 Randomized Study Comparing Pre- and Postoperative vs. Conventional Adjuvant Treatment in Receptor-negative Patients October 1991 September 2000
NCT00311636 Completed Phase 3 Triptorelin in Preventing Early Menopause in Premenopausal Women Who Are Receiving Chemotherapy for Stage I, Stage II, or Stage III Breast Cancer That Has Been Removed By Surgery September 2003 April 2008
NCT00316888 Completed Phase 2 Cetuximab, Cisplatin, Fluorouracil, and Radiation Therapy in Treating Patients With Anal Cancer February 28, 2007 August 17, 2021
NCT00321685 Completed Phase 2 Bevacizumab, Radiation Therapy, and Combination Chemotherapy in Treating Patients Who Are Undergoing Surgery for Locally Advanced Nonmetastatic Rectal Cancer July 25, 2006 February 11, 2019
NCT00321828 Completed Phase 2 Combination Chemotherapy and Bevacizumab in Treating Patients With Stage IV Colon Cancer That Cannot Be Removed By Surgery March 2006 December 2012
NCT00324415 Completed Phase 2 Combined Modality Therapy for Patients With With HIV and Stage I, Stage II, or Stage III Anal Cancer September 2006 May 2016
NCT00336960 Completed Phase 2 Celecoxib, Fluorouracil, and Radiation Therapy in Treating Patients With Stage II or Stage III Rectal Cancer That Can Be Removed By Surgery July 2002 March 2008
NCT00343239 Completed Phase 2 Docetaxel in Locally Advanced Gastric Adenocarcinoma June 2006 March 2012
NCT00343408 Completed Phase 1 AZD2171 and Standard Combination Chemotherapy in Advanced Non-Small Cell Lung Cancer or Colorectal Cancer November 29, 2005 September 22, 2008
NCT00352105 Completed Phase 1/Phase 2 Cisplatin, Fluorouracil, Iressa, and Radiation Therapy Patients With Locally Advanced Head and Neck Cancer April 2006 May 2010
NCT00381862 Completed Phase 2 Phase II Trial of Aprepitant & Palonosetron for CINV Prevention w FOLFOX June 2006 July 2008
NCT00408694 Completed Phase 2 Bevacizumab, Cisplatin, Radiation Therapy, and Fluorouracil in Treating Patients With Stage IIB, Stage III, Stage IVA, or Stage IVB Nasopharyngeal Cancer December 13, 2006 December 15, 2011
NCT00416507 Completed Phase 3 Gemcitabine With or Without Combination Chemotherapy and Radiation Therapy in Treating Patients With Nonmetastatic Pancreatic Cancer That Cannot Be Removed By Surgery March 2000 January 2007
NCT00416767 Completed Phase 2 Combination Chemotherapy as First-Line Therapy in Treating Patients With Locally Advanced or Metastatic Neuroendocrine Tumors of the Duodenum or Pancreas That Cannot Be Removed By Surgery May 2004 July 2007
NCT00416858 Completed Phase 3 Radiation Therapy and Combination Chemotherapy With or Without Surgery in Treating Patients With Locally Advanced Esophageal Cancer That Can Be Removed By Surgery April 2007
NCT00422864 Completed Phase 2 A Single Arm Trial of Oxaliplatin and 5FU With Concurrent Radiation in Patients With Metastatic Rectal Cancer October 2006 January 2011
NCT00423293 Completed Phase 2 Intensity-Modulated Radiation Therapy, Fluorouracil, and Mitomycin C in Treating Patients With Invasive Anal Cancer December 2006 December 2016
NCT00423696 Completed Phase 2 Bevacizumab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery March 23, 2006 August 1, 2011
NCT00425152 Completed Phase 3 Fluorouracil and Leucovorin and/or Levamisole After Surgery In Treating Patients With Dukes' B Or Dukes' C Colon Cancer July 1989 April 2004
NCT00427310 Completed Phase 3 Liver Infusions of Fluorouracil in Treating Patients With Dukes' A, Dukes' B, or Dukes' C Colon Cancer Undergoing Surgery March 1984 February 2001
NCT00427570 Completed Phase 3 Fluorouracil, Semustine, and Vincristine Compared With BCG in Treating Patients With Dukes' B or Dukes' C Colon Cancer That Has Been Removed By Surgery September 1977 May 2006
NCT00429299 Completed Phase 2 Neoadjuvant Study With Chemotherapy, Lapatinib And Trastuzumab In Breast Cancer August 2006 June 2012
NCT00447967 Completed Phase 2 Combination of CPT-11 and LoHP vs Combination of 5-FU, Leucovorin and LoHP as 1st Line Treatment in Gastric Patients July 2004 September 2008
NCT00449137 Completed Phase 1 Arsenic Trioxide, Fluorouracil, and Leucovorin in Treating Patients With Stage IV Colorectal Cancer That Has Relapsed or Not Responded to Treatment June 2005 December 2010
NCT00462501 Completed N/A Combination Chemotherapy and Bevacizumab With or Without Radiation Therapy in Treating Patients With Locally Advanced Rectal Cancer March 2007 February 2014
NCT00462735 Completed Phase 2 Fluorouracil, Hydroxyurea, Cetuximab and Twice-daily Intensity Radiation Therapy for Advanced Head and Neck Cancer February 2007 October 2010
NCT00467142 Completed Phase 2 Bevacizumab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed by Surgery January 23, 2007 December 2011
NCT00498953 Completed Phase 1/Phase 2 Combination Chemotherapy and Radiation Therapy With or Without Lapatinib in Treating Patients With Locally Advanced Cancer of the Larynx or Hypopharynx May 2007 March 2009
NCT00507585 Completed Phase 1 Hepatic Arterial Infusion of Oxaliplatin, Fluorouracil, Leucovorin, and Avastin June 2006 January 2010
NCT00514020 Completed Phase 2 Fluorouracil, Oxaliplatin, and Leucovorin in Treating Patients With Metastatic Stomach Cancer or Gastroesophageal Junction Cancer August 2007 February 2011
NCT00537121 Completed Phase 1 Vorinostat, Irinotecan, Fluorouracil, and Leucovorin in Treating Patients With Advanced Upper Gastrointestinal Cancer November 2006 June 2013
NCT00541125 Completed Phase 2 G-CSF in Preventing Neutropenia During First-Line Treatment With Chemotherapy and Bevacizumab in Patients With Metastatic Colorectal Cancer November 2007 December 2013
NCT00544349 Completed Phase 2 Leucovorin, Fluorouracil, Cetuximab, and Oxaliplatin in Treating Patients With Stage IV Colorectal Cancer and Liver Metastases That Cannot Be Removed by Surgery October 2006
NCT00544362 Completed Phase 1/Phase 2 Fluorouracil, Cisplatin, Cetuximab, and Radiation Therapy in Treating Patients With Esophageal Cancer That Can Be Removed by Surgery July 2007 March 2013
NCT00556413 Completed Phase 2 Cetuximab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer September 2005 November 17, 2011
NCT00557102 Completed Phase 2 Cetuximab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver and/or Lung September 2007 December 2010
NCT00559455 Completed Phase 2 Phase II Study of Eloxatin+5-FU/LV in Patients With Unresectable Hepatocellular Carcinoma September 2007 January 2010
NCT00559676 Completed Phase 4 Study of Biomarkers in Patients Undergoing Chemotherapy for Metastatic Colorectal Cancer March 2005
NCT00559741 Completed Phase 2 Cetuximab and Combination Chemotherapy in Treating Patients With Advanced or Metastatic Colorectal Cancer October 2005
NCT00592501 Completed Phase 2 Proton Radiotherapy With Chemotherapy for Nasopharyngeal Carcinoma October 2006 April 2019
NCT00601627 Completed Phase 2 Panitumumab, Chemotherapy, and External-Beam Radiation Therapy in Treating Patients With Locally Advanced Pancreatic Cancer That Cannot be Removed by Surgery June 2009 May 2013
NCT00601705 Completed Phase 2 Epirubicin, Oxaliplatin and Fluorouracil (EOF) in Cancer of the Esophagus, Gastroesophageal Junction, or Stomach January 5, 2008 January 23, 2015
NCT00602602 Completed Phase 2 Bevacizumab, Combination Chemotherapy, and Radiation Therapy in Treating Patients Undergoing Surgery For Locally Advanced Pancreatic Cancer March 2007 September 2011
NCT00608205 Completed Phase 3 Radiation Therapy Cisplatin With or Without Fluorouracil Patients With Stage III or Stage IV Head and Neck Cancer January 2008 August 2016
NCT00610948 Completed Phase 1 Everolimus, Fluorouracil, Leucovorin, Panitumumab, and Oxaliplatin in Treating Patients With Tumors That Did Not Respond to Treatment March 2008 January 2016
NCT00625092 Completed Phase 1 Hyperthermic Intraperitoneal Oxaliplatin for Peritoneal Malignancies October 2007 September 2011
NCT00628810 Completed Phase 2 Combination Chemotherapy and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer January 2007 December 2008
NCT00629863 Completed N/A Endoscopic Ultrasound in Diagnosing Cancer in Patients With Localized Stomach Cancer or Esophageal Cancer September 2004 January 2010
NCT00630032 Completed Phase 3 Safety and Efficacy Comparison of Docetaxel and Ixabepilone in Non Metastatic Poor Prognosis Breast Cancer September 2007 September 3, 2020
NCT00640081 Completed Phase 2 Combination Chemotherapy and Cetuximab as First-Line Therapy in Treating Patients With Advanced and/or Metastatic Colorectal Cancer July 2007 September 2015
NCT00642577 Completed Phase 3 A Study of Avastin (Bevacizumab) in Combination With Chemotherapy in Chinese Patients With Metastatic Colorectal Cancer. July 2007 December 2010
NCT00654160 Completed Phase 1 Irinotecan, Fluorouracil, and Leucovorin in Treating Patients With Advanced Gastrointestinal Cancer June 2008 December 3, 2012
NCT00665392 Completed Phase 2 Cetuximab and Combination Chemotherapy in Patients With Stage III-IV Resectable Oropharynx Cancer February 2008 July 2012
NCT00707889 Completed Phase 2 Phase 2 Study of ABT-869 in Combination With mFOLFOX6 Versus Bevacizumab in Combination With mFOLFOX6 to Treat Advanced Colorectal Cancer October 2008 May 2012
NCT00711243 Completed Phase 1/Phase 2 Docetaxel, Oxaliplatin, and Fluorouracil in Treating Patients With Metastatic or Unresectable Stomach Cancer, Gastroesophageal Junction Cancer, or Other Solid Tumor April 20, 2005 February 25, 2011
NCT00719797 Completed Phase 3 Combination Chemotherapy and Bevacizumab as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer July 2008
NCT00721513 Completed Phase 2 Docetaxel, Cisplatin, and Fluorouracil Followed By Cetuximab and Radiation Therapy in Treating Patients With Locally Advanced Head and Neck Cancer September 2008 August 2014
NCT00749450 Completed Phase 3 Combination Chemotherapy After Surgery in Treating Patients With High-Risk Stage II or Stage III Colorectal Cancer March 2008
NCT00769405 Completed Phase 3 Systemic Chemotherapy With or Without Intraperitoneal Chemohyperthermia in Treating Patients Undergoing Surgery for Peritoneal Carcinomatosis From Colorectal Cancer February 2008
NCT00820547 Completed Phase 2 Efficacy and Tolerance Study of Bevacizumab in Her2- Inflammatory Breast Cancer Patients January 2009 September 2019
NCT00872625 Completed Phase 1 Radiation Therapy and Docetaxel Followed by Standard Therapy in Treating Women With Breast Cancer April 2007 December 2010
NCT00896181 Completed Phase 2 Phase 2 Sequential and Concurrent Chemoradiation for Advanced Nasopharyngeal Carcinoma (NPC) December 10, 2008 December 2020
NCT00929591 Completed Phase 3 SWOG-8814 Tamoxifen With or Without Combination Chemotherapy in Postmenopausal Women Who Have Undergone Surgery for Breast Cancer May 1989 March 2010
NCT00938470 Completed Phase 2 Docetaxel, Oxaliplatin, Capecitabine, Fluorouracil, and Radiation Therapy in Treating Patients With Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction January 2010 March 2018
NCT00942266 Completed Phase 2 Vorinostat, Fluorouracil, and Leucovorin Calcium in Treating Patients With Metastatic Colorectal Cancer That Has Not Responded to Previous Treatment July 2009 December 2011
NCT00952029 Completed Phase 2/Phase 3 Combination Chemotherapy and Bevacizumab With or Without Bevacizumab Maintenance Therapy in Treating Patients With Metastatic Colorectal Cancer March 2010 January 2018
NCT00957905 Completed Phase 2 Alvocidib and Oxaliplatin With or Without Fluorouracil and Leucovorin Calcium in Treating Patients With Relapsed or Refractory Germ Cell Tumors June 2009 August 2014
NCT00960284 Completed Phase 2/Phase 3 Gemcitabine or Combination Chemotherapy Followed by Chemoradiation for Stage IB, II, or III Pancreatic Cancer June 2003 June 2009
NCT00963729 Completed Phase 3 Chemotherapy or Letrozole Before Surgery in Treating Postmenopausal Women With Breast Cancer That Can Be Removed By Surgery September 2008 March 2011
NCT00975897 Completed Phase 2/Phase 3 Study of Tumor Tissue Testing in Selecting Treatment for Patients With Metastatic or Locally Advanced Colorectal Cancer July 2009 December 2012
NCT00982592 Completed Phase 2 Combination Chemotherapy With or Without Vismodegib in Treating Patients With Advanced Stomach Cancer or Gastroesophageal Junction Cancer September 2009 October 2014
NCT01013805 Completed Phase 2 Preoperative Radiotherapy and Chemotherapy in Patients With Locally Advanced Rectal Cancer November 2009 December 2012
NCT01041404 Completed Phase 3 ToGA Study - A Study of Herceptin (Trastuzumab) in Combination With Chemotherapy Compared With Chemotherapy Alone in Patients With HER2-Positive Advanced Gastric Cancer September 2005 June 2010
NCT01068327 Completed Phase 1 Stereotactic Radiation, Nelfinavir Mesylate & Neoadjuvant Chemotherapy in Locally Advanced Pancreatic Cancer November 5, 2007 February 1, 2015
NCT01164215 Completed Phase 1 Biomarker-Guided Fluorouracil in Treating Patients With Colorectal Cancer Receiving Combination Chemotherapy February 2010 September 2013
NCT01205022 Completed Phase 1 Radiolabeled Monoclonal Antibody Therapy, Combination Chemotherapy, and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer April 2011 January 2014
NCT01205711 Completed Phase 2 Irinotecan Hydrochloride, Fluorouracil, and Leucovorin Calcium With or Without Zibotentan in Treating Patients With Metastatic Colorectal Cancer April 2010 September 2012
NCT01206465 Completed Phase 1 Pralatrexate and Fluorouracil in Treating Patients With Recurrent Solid Tumors September 14, 2010 June 1, 2017
NCT01212822 Completed Phase 2 Bevacizumab and Combination Chemotherapy Before Surgery in Treating Patients With Locally Advanced Esophageal or Stomach Cancer April 27, 2011 January 3, 2018
NCT01231399 Completed Phase 1/Phase 2 Everolimus and Combination Chemotherapy in Treating Patients With Metastatic Stomach or Esophageal Cancer February 2012 July 2016
NCT01249352 Completed Phase 2/Phase 3 A Study of Chemoradiation Associated With Nimotuzumab as the Treatment of Locally Advanced Esophageal Cancer January 2009 November 2013
NCT01263171 Completed Phase 2 Oxaliplatin, Leucovorin, and Fluorouracil Before and After Radiation Therapy and Surgery in Treating Patients With Rectal Cancer That Can Be Removed by Surgery April 2012 November 2015
NCT01333033 Completed Phase 2 PET Scan Imaging in Assessing Response in Patients With Esophageal Cancer Receiving Combination Chemotherapy July 2011 April 1, 2023
NCT01360086 Completed Phase 2 Fluorouracil, Cisplatin, Leucovorin Calcium, and Cetuximab in Treating Patients With Adenocarcinoma of the Stomach or Gastroesophageal Junction June 2011 March 2013
NCT01383343 Completed Phase 1 Sorafenib Tosylate, Bevacizumab, Irinotecan Hydrochloride, Leucovorin Calcium, and Fluorouracil in Treating Patients With Metastatic Colorectal Cancer August 2011 February 2017
NCT01413022 Completed Phase 1 FOLFIRINOX Plus PF-04136309 in Patients With Borderline Resectable and Locally Advanced Pancreatic Adenocarcinoma April 2012 September 2016
NCT01467115 Completed Phase 2 Induction Chemotherapy Followed by Cetuximab and Radiation Therapy for Head and Neck Cancer March 2010 October 7, 2014
NCT01498289 Completed Phase 2 S1201: Combination Chemo for Patients W/Advanced or Metastatic Esophageal, Gastric, or Gastroesophageal Junction Cancer February 2012 September 19, 2019
NCT01534637 Completed Phase 2 Aprepitant in Preventing Nausea and Vomiting in Patients Undergoing Chemotherapy and Radiation Therapy for Pancreatic Cancer August 2006 August 2012
NCT01561014 Completed Phase 1 Oxaliplatin, Fluorouracil, Erlotinib Hydrochloride, and Radiation Therapy Before Surgery and Erlotinib Hydrochloride After Surgery in Treating Patients With Locally Advanced Cancer of the Esophagus or Gastroesophageal Junction April 2007 March 2009
NCT01566435 Completed Phase 2 Induction Chemotherapy With ACF Followed by Chemoradiation Therapy for Adv. Head & Neck Cancer August 9, 2012 October 31, 2019
NCT01567618 Completed Phase 2 Dose-dense Biweekly Docetaxel Combined With 5-fluorouracil as First-line Treatment in Advanced Gastric Cancer March 2012 April 2014
NCT01643499 Completed Phase 1 Genotype-guided Dosing of mFOLFIRINOX Chemotherapy in Patients With Previously Untreated Advanced Gastrointestinal Malignancies March 26, 2012 July 2019
NCT01658943 Completed Phase 2 Selumetinib and Akt Inhibitor MK2206 or mFOLFOX Therapy Comprising Oxaliplatin and Fluorouracil in Treating Patients With Metastatic Pancreatic Cancer Previously Treated With Chemotherapy August 2012 June 2015
NCT01666730 Completed Phase 2 Metformin Plus Modified FOLFOX 6 in Metastatic Pancreatic Cancer February 21, 2013 August 1, 2018
NCT01670721 Completed Phase 3 Colorectal Cancer Metastatic August 2012 June 2015
NCT01711541 Completed Phase 1/Phase 2 Combination Chemotherapy With or Without Veliparib in Treating Patients With Stage IV Head and Neck Cancer October 22, 2012 May 15, 2023
NCT01715233 Completed Phase 2 Phase II Study Using CHFR Methylation Status in Patients With Metastatic Esophageal, Gastroesophageal, Gastric Cancer. December 2012 April 2017
NCT01740648 Completed Phase 1 Trametinib, Fluorouracil, and Radiation Therapy Before Surgery in Treating Patients With Stage II-III Rectal Cancer November 26, 2012 September 29, 2021
NCT01747551 Completed Phase 2 FOLFOX +/- Ziv-Aflibercept for Esophageal and Gastric Cancer January 2013 July 26, 2017
NCT01775501 Completed Phase 2 Sorafenib + mFOLFOX for Hepatocellular Carcinoma January 2013 December 2019
NCT01835041 Completed Phase 1 CPI-613 and Combination Chemotherapy in Treating Patients With Metastatic Pancreatic Cancer April 2013 March 16, 2023
NCT01862003 Completed Phase 2 Phase I/II Trial of Antagonism of HER in GI Cancer May 2014 August 2, 2019
NCT01893294 Completed Phase 1 Gemcitabine Hydrochloride in Treating Patients With Locally Advanced Pancreatic Cancer April 2013 October 30, 2015
NCT01928290 Completed Phase 2 Combination Chemotherapy in Treating Patients With Advanced Stomach, Gastroesophageal, or Esophageal Cancer November 8, 2013 October 28, 2019
NCT01959672 Completed Phase 2 Chemotherapy, Stereotactic Body Radiation Therapy & Nelfinavir Mesylate in Locally Advanced Pancreatic Cancer September 6, 2013 December 1, 2018
NCT02024607 Completed Phase 1/Phase 2 A Study of BBI608 in Combination With Standard Chemotherapies in Adult Patients With Advanced Gastrointestinal Cancer January 2014 November 2019
NCT02041481 Completed Phase 1 MEK Inhibitor MEK162 in Combination With Leucovorin Calcium, Fluorouracil, and Oxaliplatin in Treating Patients With Advanced Metastatic Colorectal Cancer June 2014 January 19, 2018
NCT02042443 Completed Phase 2 Trametinib or Combination Chemotherapy in Treating Patients With Refractory or Advanced Biliary or Gallbladder Cancer or That Cannot Be Removed by Surgery February 2014 April 30, 2017
NCT02047201 Completed Phase 2 Assessing Tumor Response and IMRT Treat Plan After IC Based on FDG-PET/CT for Locally Advanced HNSCC June 2013 January 2016
NCT02124148 Completed Phase 1 A Study of Prexasertib (LY2606368) With Chemotherapy or Targeted Agents in Participants With Advanced Cancer June 18, 2014 February 13, 2020
NCT02231723 Completed Phase 1 A Study of BBI608 in Combination With Standard Chemotherapies in Adult Patients With Pancreatic Cancer August 2014 June 2020
NCT02232152 Completed Phase 1 CPI-613 and Fluorouracil in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed by Surgery January 6, 2015 January 11, 2023
NCT02244632 Completed Phase 1/Phase 2 Modufolin (Arfolitixorin) in Combination With 5-Fluorouracil Alone or Together With Oxaliplatin or Irinotecan in Colorectal Cancer September 2014 January 30, 2020
NCT02270606 Completed Phase 1 Phase I Study of Neoadjuvant Radiotherapy With 5-Fluorouracil for Rectal Cancer December 4, 2014 May 13, 2021
NCT02314117 Completed Phase 3 A Study of Ramucirumab (LY3009806) in Combination With Capecitabine and Cisplatin in Participants With Stomach Cancer January 20, 2015 August 14, 2020
NCT02319018 Completed Phase 1 Alisertib and Combination Chemotherapy in Treating Patients With Gastrointestinal Tumors August 27, 2015 September 29, 2018
NCT02333188 Completed Phase 1 Genetic Analysis-Guided Dosing of FOLFIRABRAX in Treating Patients With Advanced Gastrointestinal Cancer December 2014 December 2017
NCT02414009 Completed Phase 2 Study to Compare CAPTEM vs FOLFIRI as Second Line Treatment in Advanced, Colorectal Cancer Patients September 2014 July 30, 2019
NCT02427841 Completed Phase 2 Nab-paclitaxel and Gemcitabine Hydrochloride Followed by Radiation Therapy Before Surgery in Treating Patients With Pancreatic Cancer That Can Be Removed by Surgery January 21, 2016 December 12, 2022
NCT02562716 Completed Phase 2 S1505: Combination Chemotherapy or Gemcitabine Hydrochloride and Paclitaxel Albumin-Stabilized Nanoparticle Formulation Before Surgery in Treating Patients With Pancreatic Cancer That Can Be Removed by Surgery January 6, 2016 September 26, 2022
NCT02588105 Completed Phase 1 Study to Assess the Safety and Preliminary Efficacy of AZD0156 at Increasing Doses Alone or in Combination With Other Anti-cancer Treatment in Patients With Advanced Cancer November 10, 2015 July 26, 2022
NCT02620865 Completed Phase 1/Phase 2 BATS With in Combination With Low Dose IL-1 and GM-CSF for Advanced Pancreatic Cancer December 2015 June 21, 2021
NCT02641691 Completed Phase 2 Non-Operative Radiation Management of Adenocarcinoma of the Lower Rectum May 27, 2016 March 29, 2020
NCT02730546 Completed Phase 1/Phase 2 Pembrolizumab, Combination Chemotherapy, and Radiation Therapy Before Surgery in Treating Adult Patients With Locally Advanced Gastroesophageal Junction or Gastric Cardia Cancer That Can Be Removed by Surgery June 24, 2016 October 31, 2023
NCT02742051 Completed Phase 2 A Trial of Neoadjuvant Everolimus Plus Letrozole Versus FEC in Women With ER-positive, HER2-negative Breast Cancer June 2016 March 14, 2020
NCT02753127 Completed Phase 3 A Study of Napabucasin (BBI-608) in Combination With FOLFIRI in Adult Patients With Previously Treated Metastatic Colorectal Cancer June 2016 May 12, 2021
NCT02896907 Completed Early Phase 1 Ascorbic Acid and Combination Chemotherapy in Treating Patients With Locally Advanced or Recurrent Pancreatic Cancer That Cannot Be Removed by Surgery October 18, 2016 March 2019
NCT02921256 Completed Phase 2 Veliparib, Pembrolizumab, and Combination Chemotherapy in Treating Patient With Locally Advanced Rectal Cancer January 11, 2017 September 20, 2023
NCT03336216 Completed Phase 2 A Study of Cabiralizumab Given With Nivolumab With and Without Chemotherapy in Patients With Advanced Pancreatic Cancer December 19, 2017 June 1, 2023
NCT03414983 Completed Phase 2/Phase 3 An Investigational Immunotherapy Study of Nivolumab With Standard of Care Therapy vs Standard of Care Therapy for First-Line Treatment of Colorectal Cancer That Has Spread February 20, 2018 December 28, 2022
NCT03532711 Completed Potential Predictive Biomarkers in Patients Undergoing First-line Chemotherapy for Metastatic Colorectal Cancer January 1, 2012 December 31, 2016
NCT03617913 Completed Phase 2 Avelumab in Combination With Fluorouracil and Mitomycin or Cisplatin and Radiation Therapy in Treating Participants With Muscle-Invasive Bladder Cancer September 19, 2018 July 27, 2020
NCT03690921 Completed Phase 2 Linear Energy Transfer (LET)-Optimized Intensity Modulated Proton Therapy (IMPT) as a Component of Definitive Chemoradiation for Newly Diagnosed Squamous Cell Carcinoma of the Anal Canal: a Feasibility Trial November 8, 2018 June 3, 2022
NCT03748134 Completed Phase 3 Sintilimab or Placebo With Chemotherapy in Esophageal Squamous Cell Carcinoma ( ORIENT-15 ) December 24, 2018 July 29, 2023
NCT05178745 Completed A Prospective Observational Cohort Study Evaluating Resection Rate in Patients With Metastatic Colorectal Cancer Treated With Aflibercept in Combination With FOLFIRI - Observatoire résection September 7, 2016 May 27, 2022
NCT05009953 Not yet recruiting Phase 2 Study of Irinotecan Liposome Injection in Patients With Advanced Biliary Tract Cancer September 2021 August 2024
NCT04488159 Not yet recruiting Phase 3 Immunoscore as Decision Guidance for Adjuvant Chemotherapy in Colon Cancer December 1, 2024 June 1, 2026
NCT05846867 Not yet recruiting Phase 1/Phase 2 Study of AK119 and AK 112 With or Without Chemotherapy for Colorectal Cancer Patients May 10, 2023 July 10, 2025
NCT05047991 Not yet recruiting Phase 2 Study of Irinotecan Liposome Injection-containing Regimens Versus Nab-paclitaxel Plus Gemcitabine in Patients With Previously Untreated, Metastatic Pancreatic Adenocarcinoma October 2021 November 2024
NCT06139211 Not yet recruiting Phase 1/Phase 2 A Phase Ib/II Study Of JS015 Combination Therapy in Advanced Solid Tumors November 30, 2023 April 30, 2026
NCT06447662 Not yet recruiting Phase 1 A Study to Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation. July 28, 2024 July 12, 2028
NCT05296005 Not yet recruiting Phase 1 Neoadjuvant Therapy for the Treatment of Gastroesophageal Junction and Gastric Cancers May 31, 2022 December 31, 2024
NCT06268015 Not yet recruiting Phase 2 Botensilimab and Balstilimab Optimization in Colorectal Cancer July 2024 July 2028
NCT05493332 Not yet recruiting Phase 2 HAIC Combined With Donafenib Tosilate and Toripalimab for Unresectable HCC September 2022 September 2024
NCT06381154 Not yet recruiting Phase 2 Photoradiation With Verteporfin to Facilitate Immunologic Activity of Pembrolizumab in Unresectable, Locally Advance or Metastatic Pancreatic Cancer June 30, 2024 July 4, 2029
NCT04430738 Recruiting Phase 1/Phase 2 Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy or Pembrolizumab-containing Combinations for HER2+ Gastrointestinal Cancers September 15, 2020 October 31, 2025
NCT04762953 Recruiting Phase 2 Study of Sequential Systemic Therapy + Intraperitoneal Paclitaxel in Gastric/GEJ Peritoneal Carcinomatosis February 18, 2021 June 2025
NCT05733000 Recruiting Phase 2 CPI-613 (Devimistat) in Combination With Hydroxychloroquine and 5-fluorouracil or Gemcitabine in Treating Patients With Advanced Chemorefractory Solid Tumors March 8, 2023 March 4, 2030
NCT04821284 Recruiting Phase 1/Phase 2 Sonoporation and Chemotherapy for the Treatment of Pancreatic Cancer December 6, 2021 January 31, 2025
NCT03505320 Recruiting Phase 2 A Study to Assess the Antitumor Activity, Safety, Pharmacokinetics and Biomarkers of Zolbetuximab (IMAB362) in Participants With Claudin (CLDN) 18.2 Positive, Metastatic or Advanced Unresectable Gastric and Gastroesophageal Junction (GEJ) Adenocarcinoma and Locoregional Gastric or GEJ Adenocarcinoma June 29, 2018 December 31, 2026
NCT05802056 Recruiting Phase 1 Aldesleukin With Nivolumab and Standard Chemotherapy for Treatment of Gastric Cancer With Peritoneal Metastasis November 29, 2023 January 2026
NCT04329494 Recruiting Phase 1 PIPAC for the Treatment of Peritoneal Carcinomatosis in Patients With Ovarian, Uterine, Appendiceal, Colorectal, or Gastric Cancer August 21, 2020 December 30, 2025
NCT05836584 Recruiting Phase 2 Testing Immunotherapy (Atezolizumab) With or Without Chemotherapy in Locoregional MSI-H/dMMR Gastric and Gastroesophageal Junction (GEJ) Cancer December 6, 2023 October 31, 2027
NCT05843188 Recruiting Phase 2 Study of Hydroxychloroquine With FOLFIRI and Bevacizumab in DTP-high Metastatic Colorectal Cancer August 9, 2023 October 24, 2026
NCT04248452 Recruiting Phase 3 Testing the Addition of Radiotherapy to the Usual Treatment (Chemotherapy) for Patients With Esophageal and Gastric Cancer That Has Spread to a Limited Number of Other Places in the Body May 26, 2020 March 31, 2028
NCT03161522 Recruiting Phase 2 Chemotherapy With or Without Radiation or Surgery in Treating Participants With Oligometastatic Esophageal or Gastric Cancer February 19, 2018 December 31, 2026
NCT05651594 Recruiting Phase 2 Propranolol in Combination With Pembrolizumab and Standard Chemotherapy for the Treatment of Unresectable Locally Advanced or Metastatic Esophageal or Gastroesophageal Junction Adenocarcinoma March 7, 2023 March 30, 2026
NCT05677490 Recruiting Phase 3 mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma January 23, 2023 November 8, 2028
NCT02366819 Recruiting Phase 4 Genetic Analysis-Guided Irinotecan Hydrochloride Dosing of mFOLFIRINOX in Treating Patients With Locally Advanced Gastroesophageal or Stomach Cancer December 11, 2014 June 8, 2025
NCT04245865 Recruiting Phase 2 Tocotrienol and Bevacizumab in Metastatic Colorectal Cancer June 26, 2020 October 2024
NCT05863195 Recruiting Phase 3 Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial October 19, 2023 June 30, 2034
NCT04840264 Recruiting Phase 2 Docetaxel, Oxaliplatin and 5-FU for Gastric Cancer With Inoperable Malignant Bowel Obstruction January 7, 2022 June 30, 2027
NCT04927780 Recruiting Phase 3 Perioperative or Adjuvant mFOLFIRINOX for Resectable Pancreatic Cancer September 7, 2021 July 2029
NCT05379595 Recruiting Phase 1/Phase 2 A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer July 29, 2022 April 27, 2027
NCT05891171 Recruiting Phase 1 Study of AB598 Monotherapy and Combination Therapy in Participants With Advanced Cancers October 13, 2023 August 2025
NCT04929028 Recruiting Phase 2 Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer August 9, 2022 September 15, 2029
NCT06313801 Recruiting Phase 2 Comparing the Safety and Efficacy of First-line Polychemotherapy and Polychemotherapy in Combination With PIPAC Sessions January 19, 2023 January 19, 2026
NCT04539808 Recruiting Phase 2 NeoOPTIMIZE: Early Switching of mFOLFIRINOX or Gemcitabine/Nab-Paclitaxel Before Surgery for the Treatment of Resectable, Borderline Resectable, or Locally-Advanced Unresectable Pancreatic Cancer May 27, 2021 October 5, 2025
NCT06011772 Recruiting Early Phase 1 EGF-Depleting Therapy CIMAvax-EGF in Combination With Standard Therapy for RAS- and BRAF Wild-Type Metastatic Colorectal Cancer December 4, 2023 December 4, 2026
NCT03203525 Recruiting Phase 1 Combination Chemotherapy and Bevacizumab With the NovoTTF-100L(P) System in Treating Participants With Advanced, Recurrent, or Refractory Hepatic Metastatic Cancer June 23, 2020 December 31, 2026
NCT04205968 Recruiting Phase 2 Ramucirumab and Paclitaxel or FOLFIRI in Advanced Small Bowel Cancers June 1, 2020 June 16, 2025
NCT05564377 Recruiting Phase 2 Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial April 7, 2023 July 1, 2030
NCT04166318 Recruiting Phase 2 Lower-Dose Chemoradiation in Treating Patients With Early-Stage Anal Cancer, the DECREASE Study January 2, 2020 December 31, 2029
NCT06022861 Recruiting Phase 3 A Study to Compare the Efficacy and Safety of LY01015 and Opdivo® Combined Respectively With Chemotherapy in Advanced or Metastatic Esophageal Squamous Cell Carcinoma October 12, 2023 December 2026
NCT06028737 Recruiting Phase 2/Phase 3 Total Neoadjuvant Chemotherapy in Locally Advanced Gastric and Gastroesophageal Junction Cancer August 25, 2023 December 2031
NCT06078709 Recruiting Phase 2 Preoperative Hypofractionated Radiotherapy With FOLFOX for Esophageal or Gastroesophageal Junction Adenocarcinoma November 20, 2023 November 30, 2026
NCT05329766 Recruiting Phase 2 A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies June 10, 2022 June 2027
NCT06094140 Recruiting Phase 2 NEO-adjuvant Chemo-immunotherapy in Pancreatic Cancer May 20, 2022 June 2026
NCT05253651 Recruiting Phase 3 A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer October 24, 2022 April 30, 2028
NCT06102395 Recruiting Phase 3 Evaluating the Efficacy and Safety of Pembrolizumab Plus Standard Chemotherapy in the Neoadjuvant Treatment of Local Advanced (LA) HNSCC May 1, 2023 April 30, 2030
NCT06107413 Recruiting Phase 2 Study to Assess Adverse Events and Change in Disease Activity in Previously Treated Adult Participants Receiving Intravenous (IV) ABBV-400 With Unresectable Metastatic Colorectal Cancer in Combination With IV Fluorouracil, Folinic Acid, and Bevacizumab November 12, 2023 October 1, 2026
NCT01954992 Recruiting Phase 3 Glufosfamide Versus 5-FU in Second Line Metastatic Pancreatic Cancer April 2014 December 2025
NCT03899155 Recruiting Phase 2 Pan Tumor Rollover Study August 9, 2019 August 25, 2029
NCT05721755 Recruiting Phase 3 Combining Radiation Therapy With Immunotherapy for the Treatment of Metastatic Squamous Cell Carcinoma of the Head and Neck June 8, 2023 March 31, 2030
NCT02997228 Recruiting Phase 3 Combination Chemotherapy, Bevacizumab, and/or Atezolizumab in Treating Patients With Deficient DNA Mismatch Repair Metastatic Colorectal Cancer, the COMMIT Study January 19, 2018 November 30, 2024
NCT04745988 Recruiting Phase 2 An Open Label Phase 2 Study to Evaluate the Safety and Efficacy of Lenvatinib With Pembrolizumab or Lenvatinib, Pembrolizumab and FLOT in the Neoadjuvant / Adjuvant Treatment for Patients With Gastric Cancer November 11, 2021 August 2027
NCT05727163 Recruiting Phase 2 FOLFOX Via HAI Plus Intravenous Irinotecan With or Without Bevacizumab Versus Systemic FOLFOXIRI With or Without Bevacizumab in Initially Unresectable RAS-mutated CRLM Patients July 29, 2022 December 31, 2026
NCT06280495 Recruiting Phase 2/Phase 3 Neoadjuvant Serplulimab & Bevacizumab With FOLFOX vs. FOLFOX Alone in RAS/BRAF WT, pMMR/MSS CRC Patients February 1, 2024 December 31, 2028
NCT04340141 Recruiting Phase 3 Testing the Use of the Usual Chemotherapy Before and After Surgery for Removable Pancreatic Cancer July 1, 2020 November 2030
NCT04615013 Recruiting Phase 1 NBTXR3, Chemotherapy, and Radiation Therapy for the Treatment of Esophageal Cancer November 23, 2020 October 31, 2025
NCT05627635 Recruiting Phase 1/Phase 2 FOLFOX and Bevacizumab in Combination With Botensilimab and Balstilimab (3B-FOLFOX) for the Treatment of Microsatellite Stable (MSS) Metastatic Colorectal Cancer May 3, 2023 April 1, 2025
NCT03784326 Recruiting Phase 2 Phase I/II Study of Perioperative Chemotherapy Plus Immunotherapy Followed by Surgery in Localized Esophageal and Gastroesophageal Adenocarcinoma February 19, 2019 December 31, 2024
NCT03800693 Recruiting Phase 2 2 Versus 6 Hour Oxaliplatin Infusions in Patients With Gastrointestinal Cancers March 14, 2019 November 4, 2024
NCT04008030 Recruiting Phase 3 A Study of Nivolumab, Nivolumab Plus Ipilimumab, or Investigator's Choice Chemotherapy for the Treatment of Participants With Deficient Mismatch Repair (dMMR)/Microsatellite Instability High (MSI-H) Metastatic Colorectal Cancer (mCRC) August 5, 2019 June 10, 2026
NCT04703101 Recruiting Phase 1 Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer February 11, 2021 October 15, 2026
NCT04668976 Recruiting Phase 2 A Study of the Use of the Medtronic Pump and Codman Catheter to Give Chemotherapy to Patients With Colorectal Carcinoma or Cholangiocarcinoma November 25, 2020 December 2024
NCT06417476 Recruiting Phase 2 Short-course Radiotherapy or Long-course Chemoradiation Followed by mFOLFOXIRI Consolidation Chemotherapy for Organ Preservation in Low Rectal Cancer December 12, 2022 December 2025
NCT05482893 Recruiting Phase 1/Phase 2 PT886 For Treatment of Patients With Metastatic/Advanced Gastric, Gastroesophageal Junction and Pancreatic Adenocarcinoma (the TWINPEAK Study) March 15, 2023 April 2026
NCT06269978 Recruiting Phase 1 Intraperitoneal Oxaliplatin and Fluorouracil for the Treatment of Patients With Peritoneal Metastases From Colorectal Cancer June 30, 2024 December 31, 2025
NCT05564403 Recruiting Phase 2 Study of Chemotherapy, With or Without Binimetinib in Advanced Biliary Tract Cancers in 2nd Line Setting (A ComboMATCH Treatment Trial) February 9, 2024 January 21, 2025
NCT03073785 Recruiting Phase 2 Hypofractionated Stereotactic Body Radiation & Fluorouracil or Capecitabine for Locally Advanced Pancreatic Cancer September 16, 2016 December 2027
NCT06441565 Recruiting Phase 2/Phase 3 Fruquintinib With or Without HAI-FOLFOX for Refractory Colorectal Cancer May 24, 2024 December 30, 2029
NCT05567835 Recruiting Phase 2 A Study of Total Neoadjuvant Chemotherapy With FLOT VS Standard Perioperative FLOT in Patients With Gastric or GEJ Cancer March 6, 2024 January 2029
NCT05699603 Recruiting Phase 2 Testing the Efficacy of Topical Calcipotriene Plus 5-Fluorouracil Combination to Activate the Immune System Against Precancerous Skin Lesions in Organ Transplant Recipients August 18, 2024 February 1, 2029
NCT04354662 Recruiting Phase 2 Toripalimab Combined With FLOT Neoadjuvant Chemotherapy in Patients With Resectable Gastric Cancer September 26, 2019 June 30, 2024
NCT04005339 Recruiting Phase 2 NAPOLI-2: Fluorouracil, Leucovorin, and Nanoliposomal Irinotecan in Biliary Cancer July 29, 2019 July 31, 2024
NCT05688215 Suspended Phase 1/Phase 2 Zimberelimab and Quemliclustat in Combination With Chemotherapy for the Treatment of Patients With Borderline Resectable and Locally Advanced Pancreatic Adenocarcinoma March 7, 2023 May 1, 2026
NCT00002696 Suspended Phase 3 Combination Chemotherapy in Treating Women With Stage III Breast Cancer October 1995
NCT02897050 Suspended Phase 2 Trial of Neoadjuvant Docetaxel ± Metronomic Capecitabine/CTX Followed by FEC in Women With Operable Triple Negative Breast Cancer September 2016 September 2024
NCT04380545 Suspended Phase 1/Phase 2 Nivolumab, Fluorouracil, and Interferon Alpha 2B for the Treatment of Unresectable Fibrolamellar Cancer January 13, 2021 July 31, 2025
NCT00303628 Terminated Phase 3 Postoperative Chemotherapy With or Without Bevacizumab for Patients With Stage II or III Rectal Cancer May 11, 2006 February 11, 2019
NCT00006015 Terminated Phase 2 Combination Chemotherapy Plus Trastuzumab in Treating Patients With Advanced, Recurrent, or Metastatic Colorectal Cancer May 2000 February 2003
NCT00005944 Terminated Phase 2 Second-look Surgery With or Without Intraperitoneal Chemotherapy in Treating Patients With Recurrent Colorectal Cancer July 1, 1999 October 1, 2003
NCT00002525 Terminated Phase 3 Perioperative Chemotherapy in Treating Patients With Colon Cancer That Can Be Surgically Removed October 1, 1993 April 2015
NCT00044785 Terminated Phase 1 Phase I Study of PN401, Fluorouracil, Leucovorin and CPT-11 in Patients With Solid Tumors August 2002 March 2004
NCT03009058 Terminated Phase 1/Phase 2 Study of IMM 101 in Combination With Standard of Care in Patients With Metastatic or Unresectable Cancer May 24, 2017 August 30, 2017
NCT00720512 Terminated Phase 3 Second-Line Combination Chemotherapy With or Without Bevacizumab in Treating Patients With Metastatic Colorectal Cancer Who Have Received First-Line Chemotherapy and Bevacizumab June 2008 March 2014
NCT00352118 Terminated Phase 2 Combination Chemotherapy and Radiation Therapy in Treating Patients With Locally Advanced Head and Neck Cancer March 2006 April 2008
NCT01779050 Terminated Phase 2 Effect of Trastuzumab on Disease Free Survival in Early Stage HER2-Negative Breast Cancer Patients With ERBB2 Expressing Disseminated Tumor Cells December 19, 2013 September 1, 2021
NCT01229111 Terminated Phase 2 Cediranib Maleate and Combination Chemotherapy in Treating Patients With Advanced Biliary Cancers October 2010 March 2014
NCT03300544 Terminated Phase 1 Talimogene Laherparepvec, Chemotherapy, and Radiation Therapy Before Surgery in Treating Patients With Locally Advanced or Metastatic Rectal Cancer May 14, 2019 March 22, 2022
NCT03300609 Terminated Phase 3 5-FU Based Maintenance Therapy in RAS Wild Type Metastatic Colorectal Cancer After Induction With FOLFOX Plus Panitumumab February 27, 2018 October 3, 2019
NCT01238965 Terminated Phase 1 Panobinostat and Fluorouracil Followed By Leucovorin Calcium in Treating Patients With Stage IV Colorectal Cancer Who Did Not Respond to Previous Fluorouracil-Based Chemotherapy October 2010 April 2015
NCT00043004 Terminated Phase 2 Chemotherapy and Bevacizumab With or Without Radiofrequency Ablation in Treating Unresectable Liver Metastases in Patients With Colorectal Cancer May 2002
NCT01897454 Terminated Phase 2 Gemcitabine Hydrochloride, and Radiation Therapy in Patients With Borderline Resectable Pancreatic Cancer January 27, 2012 November 1, 2021
NCT00004897 Terminated Phase 2 Combination Chemotherapy and Interferon Alfa Followed by Surgery and/or Radiation Therapy in Treating Patients With Stage I, Stage II, or Stage III Esophageal Cancer October 1999 November 2007
NCT03387098 Terminated Phase 1/Phase 2 QUILT-3.070:Pancreatic Cancer Vaccine: Subjects With Pancreatic Cancer Who Have Progressed on or After Standard-of-care Therapy December 28, 2017 January 15, 2019
NCT02017600 Terminated Phase 2 A Phase II Trial of Induction Chemotherapy With ND-420, Cisplatin and Fluorouracil Followed by Surgery in the Treatment of Patients With Localized Squamous Cell Carcinoma of the Esophagus August 2013 April 4, 2015
NCT00499369 Terminated Phase 3 Irinotecan and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic Colorectal Cancer That Progressed During First-Line Therapy June 2007 November 2012
NCT00524186 Terminated Phase 1 Sunitinib, Irinotecan, Fluorouracil, and Leucovorin In Treating Patients With Advanced Stomach Cancer or Gastroesophageal Cancer May 2007 April 2016
NCT00537823 Terminated Phase 2 Pre- and Post-operative FOLFOX Based Therapy for Patients With Colorectal Cancer With Liver Involvement June 2007 July 2011
NCT00541112 Terminated Phase 2 Radiation Therapy, Chemotherapy, and Cetuximab Followed by Surgery, Chemotherapy, and Cetuximab in Treating Patients With Locally Advanced or Metastatic Rectal Cancer That Can Be Removed by Surgery October 29, 2007 January 29, 2010
NCT00004099 Terminated Phase 3 Surgery With or Without Combination Chemotherapy in Treating Patients With Stomach Cancer July 1999
NCT01279681 Terminated Phase 3 Combination Chemotherapy Plus Bevacizumab With or Without Oxaliplatin in Treating Older Patients With Metastatic Colorectal Cancer January 2011 November 1, 2014
NCT01280643 Terminated N/A Combination Chemotherapy and Cetuximab or Bevacizumab in Treating Patients With Metastatic Colorectal Cancer March 2010 May 2014
NCT00053911 Terminated Phase 3 Combination Chemotherapy Compared With Observation After Surgery in Treating Women With Relapsed Nonmetastatic Breast Cancer November 2002
NCT01307956 Terminated Phase 2 Panitumumab, Combination Chemotherapy, & Radiation Therapy in Esophageal or Gastroesophageal Junction Cancer February 28, 2011 December 23, 2015
NCT01320683 Terminated Phase 2 Combination Chemotherapy and Bevacizumab Before Surgery and Radiolabeled Monoclonal Antibody Therapy in Treating Liver Metastases in Patients With Metastatic Colorectal Cancer March 2011 December 2014
NCT00646659 Terminated Phase 2 Cetuximab, Combination Chemotherapy, and Radiation Therapy in Treating Patients With Newly Diagnosed Stage III or Stage IV Head and Neck Cancer That Cannot Be Removed By Surgery February 2008 April 2011
NCT00030511 Terminated Phase 2 Radiation Therapy and Fluorouracil Before Surgery in Treating Patients With Primary or Recurrent Bile Duct Cancer October 2001
NCT01197664 Terminated Phase 1 Paricalcitol, Fluorouracil, and Radiation Therapy in Treating Patients With Rectal Cancer That Can Be Removed in Surgery August 2010 April 2014
NCT00003777 Terminated Phase 2 Surgery, Radiation Therapy, and Combination Chemotherapy in Treating Patients With Recurrent Head and Neck Cancer December 1998 April 20, 2001
NCT00602329 Terminated Phase 2 MRI in Predicting Response in Patients Receiving Combination Chemotherapy and Bevacizumab For Advanced or Metastatic Colorectal Cancer February 2006 October 2009
NCT00064259 Terminated Phase 1/Phase 2 A Phase I/II Study of Oblimersen Plus Cisplatin and Fluorouracil in Gastric & Esophageal Junction Cancer June 2003 February 2010
NCT00609765 Terminated Phase 2 Avastin, Fluorouracil, Doxorubicin and Streptozocin in Locally Advanced and Metastatic Pancreatic Endocrine Tumors August 2007 March 2008
NCT00003642 Terminated Phase 2 Radiation Therapy and Chemotherapy Following Surgery in Treating Patients With Stage II or Stage III Bladder Cancer October 1998
NCT01198548 Terminated Phase 2 High-Dose Cholecalciferol in Treating Patients Receiving Combination Chemotherapy and Bevacizumab as First-Line Therapy For Metastatic Colorectal Cancer August 2010 June 2012
NCT01375816 Terminated Phase 2 Liposome-encapsulated Irinotecan Hydrochloride PEP02 or Irinotecan Hydrochloride, Leucovorin Calcium, and Fluorouracil as Second-Line Therapy in Treating Patients With Metastatic Colorectal Cancer May 2011 December 2014
NCT03878524 Terminated Phase 1 Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial April 1, 2020 December 10, 2020
NCT00642746 Terminated Phase 2 Erlotinib and Chemotherapy for 2nd Line Treatment (Tx) of Metastatic Colorectal Cancer (mCRC) March 2008 December 2011
NCT00068744 Terminated Phase 2/Phase 3 Radiation Therapy, Mitomycin, and Either Fluorouracil or Cisplatin in Treating Patients With Locally Advanced Anal Cancer July 2003
NCT00070122 Terminated Phase 3 Combination Chemotherapy and Bevacizumab in Treating Patients With Locally Advanced, Metastatic, or Recurrent Colorectal Cancer April 2004
NCT00955240 Terminated Phase 2 Radiation Therapy, Cisplatin, Fluorouracil, and Cetuximab in Treating Patients With Locally Advanced Anal Cancer March 2009 November 26, 2010
NCT00002735 Terminated Phase 2 SWOG-9451, Combination Chemo & RT For Patients With Stage III/Stage IV Cancer of the Hypopharynx or Tongue April 1996 March 2005
NCT00002796 Terminated Phase 1/Phase 2 Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced Colorectal Cancer May 1997
NCT00006472 Terminated Phase 2 Combination Chemotherapy Plus Radiation Therapy Followed By Surgery in Treating Patients With Stage I, Stage II, or Stage III Esophageal Cancer January 2000 September 10, 2002
NCT02345460 Terminated Phase 2 Preoperative Folfirinox for Resectable Pancreatic Adenocarcinoma - A Phase II Study September 2015 March 2016
NCT01479465 Terminated Phase 2 Efficacy and Safety of Simtuzumab (SIM) With FOLFIRI as Second Line Treatment in Colorectal Adenocarcinoma December 2011 February 2015
NCT01123473 Terminated Phase 2 Epirubicin Hydrochloride, Cisplatin, and Fluorouracil or Capecitabine With or Without Lapatinib Ditosylate as First-Line Therapy in Treating Patients With Stomach Cancer or Gastroesophageal Junction Cancer December 2010 September 2014
NCT02392377 Terminated Phase 2 Molecular Phenotyping in Predicting Response in Patients With Stage IB-III Esophageal Cancer Receiving Combination Chemotherapy February 2015 December 2015
NCT00103103 Terminated Phase 2 Bortezomib, Fluorouracil, and Leucovorin in Treating Patients With Metastatic or Unresectable Stomach Cancer March 2005 August 2005
NCT00113399 Terminated Phase 3 Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Recurrent Head and Neck Cancer That Cannot Be Removed By Surgery April 2005
NCT02508077 Terminated Phase 2 FOLFIRI and Panitumumab in Treating Patients With RAS and BRAF Wild-Type Metastatic Colorectal Cancer February 16, 2016 September 13, 2017
NCT00023868 Terminated Phase 3 Combination Chemotherapy With or Without Chemoembolization in Treating Patients With Colorectal Cancer Metastatic to the Liver (6655) November 1, 2001 September 25, 2002
NCT00052585 Terminated Phase 2 Gefitinib and Combination Chemotherapy in Treating Patients With Advanced or Recurrent Colorectal Cancer October 2002
NCT00262951 Terminated Phase 2 Chemoradiation in Locally Advanced Pancreatic Cancer January 2005 August 2011
NCT00766142 Terminated Phase 2 Chemotherapy and Cetuximab in Patients Undergoing Surgery for Peritoneal Carcinomatosis From Colorectal Cancer May 1, 2007 September 17, 2013
NCT00003086 Terminated Phase 1/Phase 2 Repeated Bone Marrow Transplantation in Treating Women With Advanced Breast Cancer March 1997 January 28, 2001
NCT00006037 Terminated Phase 2 Chemotherapy Plus IM-862 in Treating Patients With Metastatic Colorectal Cancer November 1999 November 2001
NCT01093235 Unknown status Phase 3 Combination Chemotherapy With or Without Bevacizumab in Treating Patients With Nonmetastatic Breast Cancer April 2009
NCT00016042 Unknown status Phase 1 Fluorouracil and Biological Therapy in Treating Patients With Metastatic Kidney or Colorectal Cancer January 2001
NCT00002884 Unknown status Phase 3 Chemotherapy and Radiation Therapy in Treating Patients With Cancer of the Esophagus March 1996
NCT01167725 Unknown status Phase 3 Standard Therapy With or Without Surgery and Mitomycin C in Treating Patients With Advanced Limited Peritoneal Dissemination of Colon Cancer August 2010
NCT00002793 Unknown status Phase 3 Chemotherapy Via an Implantable Pump Compared With a Subcutaneous Port for Unresectable Liver Metastases in Patients With Resected Colorectal Cancer January 1991
NCT01211210 Unknown status Phase 2/Phase 3 Neoadjuvant FOLFOX6 Chemotherapy With or Without Radiation in Rectal Cancer June 2010 June 2020
NCT00002747 Unknown status Phase 3 Surgery and Radiation Therapy With or Without Chemotherapy in Treating Patients With Mouth Cancer September 1992
NCT04755543 Unknown status Phase 1 A Study of LP002 for the Treatment of Patients With Malignant Digestive System Neoplasms June 17, 2019 June 30, 2022
NCT01391572 Unknown status Phase 2 A Trial Estimating The Optimal Radiation Volume Of Postsurgical Radiation For Patients With Esophageal Cancer April 2011
NCT01494363 Unknown status Phase 2 Phase II Study of FOLFOXIRI in Patients With Locally Advanced or Metastatic Biliary Tract Cancer October 2011 December 2013
NCT00002692 Unknown status Phase 3 Intravenous Compared With Intrahepatic Chemotherapy in Treating Patients With Colorectal Cancer Metastatic to the Liver December 1994
NCT01652196 Unknown status Phase 2 Aflibercept and FOLFOX6 Treatment for Previously Untreated Stage IV Colorectal Cancer November 14, 2012 December 31, 2019
NCT01814501 Unknown status Phase 2 Panitumumab and Chemotherapy in Patients With Advanced Colorectal Cancer After Prior Therapy With Bevacizumab February 1, 2013 December 31, 2019
NCT00012311 Unknown status Phase 2 Chemotherapy Plus Peripheral Stem Cell Transplantation Compared With Chemotherapy Alone in Treating Women With Stage IV Breast Cancer January 2000
NCT00010088 Unknown status Phase 2 Chemotherapy in Treating Patients With Locally Advanced or Metastatic Cancer of the Pancreas or Bile Duct January 1999
NCT01880385 Unknown status Phase 1 Efficacy and Safety of Bevacizumab in the Neodjuvant Treatment of Inflammatory Breast Cancer March 2011 April 2017
NCT00002498 Unknown status Phase 2 Combination Chemotherapy Compared With Mitoxantrone in Treating Older Patients With Advanced Breast Cancer July 1992
NCT02021422 Unknown status Phase 1 A Pilot, Prospective, Non-randomized Evaluation of the Safety of Anakinra Plus Standard Chemotherapy June 2013 December 2017
NCT00010075 Unknown status Phase 2 Combination Chemotherapy in Treating Older Women With Metastatic Breast Cancer January 2000
NCT00010062 Unknown status Phase 2 Fluorouracil Plus Radiation Therapy Following Surgery in Treating Patients With Pancreatic Cancer October 2000
NCT00058474 Unknown status Phase 3 Radiation Therapy and Either Capecitabine or Fluorouracil With or Without Oxaliplatin Before Surgery in Treating Patients With Resectable Rectal Cancer July 2004 May 2016
NCT00008281 Unknown status Phase 3 Comparison of Three Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer October 2000
NCT02071069 Unknown status Phase 2 Efficacy and Tolerance of Maintenance Therapy in Patients With Incurable Advanced Colorectal Cancer July 2013 July 2016
NCT02115152 Unknown status Phase 2 Neoadjuvant Trial of Capecitabine for Axillary Lymph Node Positive Operable Breast Cancer June 2014
NCT00008047 Unknown status Phase 1/Phase 2 Combination Chemotherapy Combined With Radiation Therapy in Treating Patients Who Have Stage II or Stage III Cancer of the Esophagus August 1999
NCT00006479 Unknown status Phase 3 Surgery With or Without Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal Cancer September 2000
NCT00072553 Unknown status Phase 2 Celecoxib, Leucovorin, Fluorouracil, and Oxaliplatin in Treating Patients With Metastatic Colorectal Cancer September 2003
NCT00075595 Unknown status Phase 2 Fluorouracil, Leucovorin, and Irinotecan in Treating Patients With Recurrent or Refractory Metastatic Unresectable Colorectal Cancer June 2002
NCT00075738 Unknown status Phase 2 Fluorouracil, Irinotecan, Leucovorin, and Cisplatin as First-Line Therapy in Treating Patients With Metastatic Esophageal Cancer October 2003
NCT00079365 Unknown status N/A Fluorouracil, External-Beam Radiation Therapy, and Gemcitabine With or Without Brachytherapy Using Phosphorus P32 in Treating Patients With Locally or Regionally Advanced Unresectable Adenocarcinoma of the Pancreas May 2001
NCT02325986 Unknown status Phase 2 Concurrent Radiotherapy and Weekly Chemotherapy of PF for Postoperative Locoregional Recurrence of Esophageal Cancer March 2015 December 2017
NCT00091312 Unknown status Phase 3 Fluorouracil and Irinotecan With or Without Leucovorin Compared With Observation in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer June 2004
NCT00093665 Unknown status Phase 2 Fluorouracil, Cisplatin, and Radiation Therapy in Treating Patients With Stage II, Stage III, or Stage IV Nasopharyngeal Cancer November 2003
NCT02415699 Unknown status Phase 2/Phase 3 DC-CIK Immunotherapy Plus Chemotherapy vs Chemotherapy Alone in the Adjuvant Treatment of Stage III Colorectal Cancer August 2015 July 2020
NCT00006468 Unknown status Phase 3 Comparing Two Combination Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer January 2000
NCT00006115 Unknown status Phase 2 Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer April 1999
NCT02500940 Unknown status Phase 3 Comparison the Effects of Different Neoadjuvant Chemotherapy Regimen on Acute Toxicity, Tumor Response, and Survival in Patients With Advanced Nasopharyngeal Carcinoma May 2015 May 2021
NCT02506842 Unknown status Phase 3 Second-Line Adjuvant Therapy With Nab-Paclitaxel Plus Gemcitabine Versus Oxaliplatin Plus Folinic Acid and Fluorouracil for Gemcitabine-Refractory Pancreatic Cancer After Curative Resection June 2015 June 2019
NCT02515734 Unknown status Phase 2 A Study of FOLFOXIRI Plus Cetuximab vs. FOLFOXIRI Plus Bevacizumab August 2015 June 2020
NCT00006112 Unknown status Phase 2 Fluorouracil With or Without Mitomycin in Treating Patients With Peritoneal Cancer January 1996
NCT00182715 Unknown status Phase 3 Combination Chemotherapy With or Without Cetuximab as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer March 2005
NCT00274872 Unknown status Phase 2/Phase 3 Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery January 2004
NCT00275119 Unknown status Phase 2 Gemcitabine and Oxaliplatin Followed By Radiation Therapy, Fluorouracil, and Oxaliplatin in Treating Patients With Locally Advanced Pancreatic Cancer That Cannot Be Removed By Surgery November 2003
NCT00046995 Unknown status Phase 3 Combination Chemotherapy in Treating Patients With Colon Cancer May 2001
NCT00309920 Unknown status N/A Combination Chemotherapy With or Without Darbepoetin Alfa in Treating Women With Stage III Breast Cancer January 2004
NCT02969473 Unknown status Phase 2 Definitive Concurrent Chemoradiotherapy With Docetaxel Plus Cisplatin Versus 5-fluorouracil Plus Cisplatin in Patients With Esophageal Squamous Cell Carcinoma October 2010 May 2017
NCT03002064 Unknown status Phase 3 Docetaxol Plus Cisplatin Versus 5-Fu Plus Cisplatin as 1st-line Chemotherapy in Advanced ESCC Patients December 2016 December 2020
NCT03045770 Unknown status N/A mFOLFOX Versus mFOLFIRI Versus FOLFPTX as First-line Treatment in AGC or EGJA February 10, 2017 December 30, 2019
NCT00408551 Unknown status Phase 2 Chemotherapy and Internal Radiation in Treating Patients With Colorectal Cancer That Has Spread to the Liver November 2005
NCT00005871 Unknown status Phase 3 Nitrocamptothecin or Fluorouracil in Treating Patients With Recurrent or Refractory Pancreatic Cancer November 1998
NCT03167112 Unknown status Phase 2 A Study of Administering FOLFIRINOX Before Surgery For Potentially Curable Pancreatic Cancer July 3, 2017 May 2018
NCT00005870 Unknown status Phase 3 Nitrocamptothecin Compared With Other Chemotherapy in Treating Patients With Recurrent or Refractory Cancer of the Pancreas March 1999
NCT03221400 Unknown status Phase 1/Phase 2 PEN-866 in Patients With Advanced Solid Malignancies August 29, 2017 June 2023
NCT00425425 Unknown status Phase 1/Phase 2 Cetuximab, Oxaliplatin, Fluorouracil, and Radiation Therapy in Treating Patients With Stage II or Stage III Esophageal Cancer July 2006 May 2015
NCT00005607 Unknown status Phase 2 Combination Chemotherapy in Treating Patients With Metastatic or Recurrent Cancer of the Stomach or Esophagus February 2000
NCT00005581 Unknown status Phase 3 Combination Chemotherapy in Treating Women With Stage II or Stage III Breast Cancer June 2000
NCT00436267 Unknown status Phase 2 Internal Radiation Therapy With Y-90 Microspheres, External Radiation Therapy With Tomotherapy, and Fluorouracil in Treating Patients With Newly Diagnosed or Recurrent Pancreatic Cancer and Liver Metastases That Cannot Be Removed By Surgery November 2006
NCT00438737 Unknown status Phase 2 Cetuximab, Leucovorin, Oxaliplatin, and Fluorouracil With or Without Bevacizumab in Treating Patients With Resectable Liver Metastases From Colorectal Cancer January 2007
NCT03349177 Unknown status Phase 2/Phase 3 Pathological Complete Response Rate in Locally Advanced Breast Cancer With FEC, EC-T, or TC as Neoadjuvant Chemotherapy November 27, 2017 November 27, 2019
NCT00004206 Unknown status Phase 2 Oxaliplatin and Fluorouracil in Treating Patients With Recurrent Ovarian Cancer September 1999
NCT00471484 Unknown status Phase 2 Combination Chemotherapy and Interferon Alfa-2b in Treating Patients With Nonmetastatic Liver Cancer That Cannot Be Removed by Surgery March 2007
NCT00482222 Unknown status Phase 3 Combination Chemotherapy With or Without Cetuximab Before and After Surgery in Treating Patients With Resectable Liver Metastases Caused By Colorectal Cancer February 2007
NCT00041262 Unknown status Phase 3 Combination Chemotherapy in Treating Patients With Esophageal Cancer November 2004
NCT00004164 Unknown status Phase 2 Combination Chemotherapy in Treating Patients With Stage IIB, Stage III, or Stage IV Cancer of the Nasopharynx August 1999
NCT00513266 Unknown status Phase 2 Combination Chemotherapy and Monoclonal Antibody Therapy in Treating Patients With Advanced Colorectal Cancer With Liver Metastases or Lung Metastases That Are Potentially Removable by Surgery June 2007
NCT00533936 Unknown status Phase 2 Trastuzumab or Observation After Combination Chemotherapy and Trastuzumab in Treating Patients Undergoing Surgery for Stage II or Stage III Breast Cancer September 2006
NCT03522649 Unknown status Phase 3 A Phase III Clinical Study of Napabucasin (GB201) Plus FOLFIRI in Adult Patients With Metastatic Colorectal Cancer April 12, 2018 November 2021
NCT00544011 Unknown status Phase 2 Bevacizumab and Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer April 2007
NCT03579004 Unknown status Phase 2 Neoadjuvant Chemotherapy Followed by Preoperative Chemoradiation in Resectable Squamous-cell Esophageal Cancer July 10, 2017 July 10, 2020
NCT00033683 Unknown status Phase 2 Combination Chemotherapy in Treating Women With Resected Breast Cancer February 2001
NCT00004097 Unknown status Phase 1 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Advanced and/or Recurrent Head and Neck Cancer August 1999
NCT03668418 Unknown status Xenotransplantation of Primary Cancer Samples in Zebrafish Embryos June 1, 2018 May 31, 2022
NCT00004094 Unknown status Phase 2 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Previously Untreated Advanced Cancer of the Mouth, Pharynx, or Larynx August 1999
NCT03732508 Unknown status Phase 2 SHR-1316 in Combination With Chemotherapy in Patients With Esophageal Squamous Cell Cancer November 2018 October 2020
NCT00003680 Unknown status Phase 3 Standard Chemotherapy Compared With High-Dose Chemotherapy Plus Peripheral Stem Cell Transplant in Treating Women With Advanced or Inflammatory Breast Cancer November 1998
NCT00003664 Unknown status Phase 2 Combination Chemotherapy and Biological Therapy In Treating Patients With Kidney Cancer That Is Metastatic or Cannot Be Removed Surgically October 1998
NCT00629278 Unknown status Phase 3 Combination Chemotherapy and Trastuzumab in Treating Women With Stage I, Stage II, or Stage III HER2-Positive Breast Cancer December 2007
NCT00003637 Unknown status Phase 3 Radiation Therapy Alone Compared to Radiation Therapy Plus Chemotherapy in Treating Patients With Previously Untreated Cancer of the Nasopharynx September 1998
NCT03910634 Unknown status Phase 2 IMRT With Carboplatin Versus IMRT With Carboplatin and Fluorouracil for Eldly Esophageal Cancer Patients April 9, 2019 December 31, 2021
NCT00647530 Unknown status Phase 2/Phase 3 Fluorouracil and Oxaliplatin With or Without Panitumumab In Treating Patients With High-Risk Colon Cancer That Can Be Removed by Surgery May 15, 2008 December 31, 2019
NCT03925233 Unknown status Breast Cancer Treatment Based on Organ-like Culture January 2, 2019 December 15, 2021
NCT00003558 Unknown status Phase 3 Chemotherapy in Treating Patients With Cancer of Unknown Primary Origin August 1998
NCT00027833 Unknown status Phase 2 Vaccine Therapy and Chemotherapy With or Without Tetanus Toxoid Compared With Chemotherapy Alone in Treating Patients With Metastatic Colorectal Cancer December 2001
NCT00003260 Unknown status Phase 3 Combination Chemotherapy in Treating Patients With Recurrent Metastatic Colorectal Cancer January 1998
NCT00003135 Unknown status Phase 2 Whole Body Hyperthermia Combined With Chemotherapy in Treating Patients With Metastatic Breast, Ovarian, Endometrial, or Cervical Cancer November 1997
NCT00766480 Unknown status N/A Study of Tissue Samples in Predicting How Well Chemotherapy and Radiation Therapy Will Kill Cancer Cells in Patients With Squamous Cell Carcinoma of the Esophagus January 2007
NCT00003063 Unknown status Phase 3 Biological Therapy With Combination Chemotherapy in Patients With Colorectal Cancer November 1991
NCT00797485 Unknown status Phase 3 Bevacizumab and Combination Chemotherapy in Treating Patients With Previously Untreated Metastatic Colorectal Cancer That Cannot Be Removed By Surgery July 2008
NCT00884767 Unknown status Phase 2 Biomarkers in Predicting Neurotoxicity in Patients With Colorectal Cancer Receiving Oxaliplatin September 2007
NCT00003001 Unknown status Phase 1/Phase 2 Combination Chemotherapy in Treating Patients With Recurrent or Metastatic Colorectal Cancer April 1997
NCT00002896 Unknown status Phase 3 Radiation Therapy Plus Chemotherapy Before Surgery With or Without Chemotherapy After Surgery in Treating Patients With Rectal Cancer September 1993
NCT00022178 Unknown status Phase 3 Combination Chemotherapy in Treating Patients With Metastatic Cancer of an Unknown Site of Origin December 1998
NCT00021281 Unknown status Phase 3 Combination Chemotherapy With or Without SU5416 in Treating Patients With Metastatic Colorectal Cancer December 2000
NCT01031030 Unknown status Phase 3 Cyclophosphamide, Methotrexate, and Fluorouracil, With or Without Epirubicin Hydrochloride, in Treating Women Who Have Undergone Surgery for Breast Cancer (Group III Closed to New Patients as of 12/7/2009) November 1997
NCT00002893 Unknown status Phase 3 Palliative Chemotherapy in Treating Patients With Advanced Colorectal Cancer June 1995
NCT02575508 Withdrawn Phase 1/Phase 2 Pan FGFR Kinase Inhibitor BGJ398 and Combination Chemotherapy in Treating Patients With Untreated Metastatic Pancreatic Cancer
NCT02573220 Withdrawn Phase 1 Irinotecan Hydrochloride With FOLFIRI and Cetuximab as First-Line Therapy in Treating Patients With RAS Wild-Type Colorectal Cancer June 2015 August 2016
NCT01270438 Withdrawn Phase 2 Combination Chemotherapy and Bevacizumab With or Without RO4929097 in Treating Patients With Metastatic Colorectal Cancer December 2010 August 2013
NCT01142414 Withdrawn Phase 3 Chemotherapy and Radiation Therapy With or Without Panitumumab in Treating Patients Who Have Undergone Surgery for Advanced Hypopharyngeal Cancer, Oropharyngeal Cancer, Laryngeal Cancer, or Oral Cavity Cancer at High Risk of Recurrence
NCT00002999 Withdrawn Phase 2 S9715, Chemotherapy and Radiation Therapy in Treating Patients With Advanced Cancer of the Nasopharynx
NCT00936832 Withdrawn Phase 2 Sunitinib Malate and Combination Chemotherapy as Front-Line Therapy in Treating Patients With Metastatic Rectal Cancer That Cannot Be Removed by Surgery April 2009 March 24, 2010
NCT00571740 Withdrawn Phase 2 Cetuximab and Bevacizumab as First-Line Therapy Followed By Combination Chemotherapy and Bevacizumab With or Without Cetuximab as Second-Line Therapy in Treating Patients With Stage IV Colorectal Cancer
NCT02413853 Withdrawn Phase 2 Combination Chemotherapy and Bevacizumab With or Without PRI-724 in Treating Patients With Newly Diagnosed Metastatic Colorectal Cancer November 2015 November 2018
NCT02344810 Withdrawn Phase 1/Phase 2 C-Met Inhibitor AMG 337, Oxaliplatin, Leucovorin Calcium, and Fluorouracil in Treating Patients With Advanced Stomach or Esophageal Cancer March 6, 2015
NCT02296671 Withdrawn Phase 2 Personalized Therapy for Esophagogastric Cancer Using Thymidylate Synthase Genetic Markers February 2015 February 2022
NCT00070434 Withdrawn Phase 2 S0304 Induct Chemo Then Chemo-RT in Pts w/Locally Advanced Adenocarcinoma of the Rectum August 2004
NCT02235324 Withdrawn Phase 2 Ziv-Aflibercept Followed by Ziv-Aflibercept, Fluorouracil, and Leucovorin Calcium in Treating Patients With Stage IV Colorectal Cancer March 2015 March 2018
NCT03386838 Withdrawn Phase 3 An Immuno-therapy Study of Nivolumab in Combination With Experimental Medication BMS-986205 Compared to Standard of Care EXTREME Regimen in First-line Recurrent/Metastatic Squamous Cell Carcinoma of Head and Neck March 28, 2018 April 19, 2018
NCT03110510 Withdrawn Phase 2 FOLFIRI as Salvage Treatment in Metastatic Biliary Tract Cancer (BTC) Patients Who Were Failed After Gemcitabine Containing Chemotherapy: A Phase II Single Arm Prospective Study September 6, 2019 September 6, 2019
NCT03069950 Withdrawn Phase 2 Study of Chemotherapy With or Without Hepatic Arterial Infusion for Patients With Unresectable Metastatic Colorectal Cancer to the Liver February 28, 2017 May 16, 2019
NCT01941173 Withdrawn N/A Short-Infusion Ziv-aflibercept in Treating Patients With Metastatic Colorectal Cancer Receiving Combination Chemotherapy January 2014
NCT02856867 Withdrawn Phase 2 Nintedanib Plus mFOLFOX6 for Previously Untreated Metastatic Esophagogastric Adenocarcinoma (MEGAN) December 2016
NCT00006106 Withdrawn Phase 1 ONYX-015 With Cisplatin and Fluorouracil in Treating Patients With Advanced Head and Neck Cancer July 1999
NCT04480190 Withdrawn Phase 1 Neoadjuvant Therapy in Biliary Adenocarcinoma February 4, 2021 April 4, 2022
NCT01473303 Withdrawn Phase 1/Phase 2 Combination Chemotherapy With or Without Ganitumab in Treating Patients With Previously Untreated Metastatic Pancreatic Cancer August 2012
NCT01159236 Withdrawn N/A Molecular Triaging of Newly Diagnosed Breast Cancer September 2010
NCT00238160 Withdrawn Phase 3 Surgery With or Without Hepatic Arterial Chemotherapy in Treating Patients With Liver Cancer