colorectal adenocarcinoma (Cancer)
Information
- Disease name
- colorectal adenocarcinoma
- Disease ID
- DOID:0050861
- Description
- "A colorectal carcinoma that derives_from epithelial cells of glandular origin." [url:http\://cancergenome.nih.gov/cancersselected/colorectaladenocarcinoma, url:http\://en.wikipedia.org/wiki/Adenocarcinoma]
Disease area statistics
[No Data.]
Chromosome band
[No Data.]
Annotation
| Genes | Mutation | Description | Source | Links |
|---|
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT03599752 | Active, not recruiting | Phase 2 | Chemotherapy and/or Metastasectomy in Treating Patients With Metastatic Colorectal Adenocarcinoma With Lung Metastases | July 2, 2018 | January 31, 2030 |
| NCT03369041 | Active, not recruiting | Study of the Practice of Debiri in France | February 3, 2016 | October 15, 2022 | |
| NCT05678257 | Active, not recruiting | Phase 2 | A Study of NUC-3373 in Combination With Other Agents in Patients With Colorectal Cancer | April 18, 2023 | March 2025 |
| NCT06339346 | Active, not recruiting | Analysis of Histopathological Factors Predictive of Lymph Node Involvement and Management Practices in pT1 Colorectal Cancers Treated by Primary Endoscopic Resection: a Retrospective Population-based Study (PROMOT1) | December 1, 2022 | April 30, 2024 | |
| NCT04731467 | Active, not recruiting | Phase 1/Phase 2 | A Study of CM24 in Combination With Nivolumab in Adults With Advanced Solid Tumors | March 19, 2021 | January 2025 |
| NCT03642067 | Active, not recruiting | Phase 2 | Study of Nivolumab and Relatlimab in Patients With Microsatellite Stable (MSS) Advanced Colorectal Cancer | February 12, 2019 | February 23, 2025 |
| NCT04474470 | Active, not recruiting | Phase 1/Phase 2 | A Study to Evaluate NT219 Alone and in Combination With ERBITUX® (Cetuximab) in Adults With Advanced Solid Tumors and Head and Neck Cancer | September 3, 2020 | June 1, 2024 |
| NCT04457284 | Active, not recruiting | Phase 2 | Temozolomide, Cisplatin, and Nivolumab in People With Colorectal Cancer | November 18, 2020 | July 2025 |
| NCT04963283 | Active, not recruiting | Phase 2 | Study of Cabozantinib and Nivolumab in Refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer | June 23, 2021 | February 9, 2026 |
| NCT03800602 | Active, not recruiting | Phase 2 | Nivolumab and Metformin in Patients With Treatment Refractory MSS Colorectal Cancer | January 15, 2019 | January 31, 2025 |
| NCT04094688 | Active, not recruiting | Phase 3 | Vitamin D3 With Chemotherapy and Bevacizumab in Treating Patients With Advanced or Metastatic Colorectal Cancer | September 30, 2019 | July 2025 |
| NCT02837263 | Completed | Phase 1 | PI Pembro in Combination With Stereotactic Body Radiotherapy for Liver Metastatic Colorectal Cancer | August 11, 2016 | May 31, 2023 |
| NCT04898842 | Completed | N/A | Feasibility Study of a 4 Stage Bowel Obstruction Cancer Diet | March 2, 2021 | November 2, 2022 |
| NCT03095781 | Completed | Phase 1 | Pembrolizumab and XL888 in Patients With Advanced Gastrointestinal Cancer | July 7, 2017 | June 10, 2021 |
| NCT03206073 | Completed | Phase 1/Phase 2 | A Phase I/II Study of Pexa-Vec Oncolytic Virus in Combination With Immune Checkpoint Inhibition in Refractory Colorectal Cancer | December 7, 2017 | June 30, 2022 |
| NCT00168155 | Completed | Phase 2 | Study of 5-FU + Leucovorin + CPT-11 in Patients With Resectable Liver Metastases From Colorectal Adenocarcinoma | January 2002 | May 2009 |
| NCT03367611 | Completed | N/A | Use of iFOBT in Patients Presenting With Alarm Symptoms of Colorectal Cancer | March 15, 2018 | December 31, 2019 |
| NCT00593060 | Completed | Phase 1 | Temsirolimus (CCI-770, Torisel) Combined With Cetuximab in Cetuximab-Refractory Colorectal Cancer | November 1, 2007 | November 2010 |
| NCT02788006 | Completed | Phase 2 | Efficacy and the Safety of Regorafenib in Patients Aged More Than 70 Years With a Metastatic Colorectal Adenocarcinoma . | January 2016 | September 2017 |
| NCT03683446 | Completed | Trends and Outcomes in Laparoscopic Versus Open Surgery for Rectal Cancer | January 1, 2005 | December 30, 2017 | |
| NCT00597506 | Completed | Phase 2 | Expanded Cohort for Metastatic Colorectal Cancer (MCRC) Using Bevacizumab + Everolimus | October 2007 | June 2010 |
| NCT00034190 | Completed | Phase 2 | Safety and Efficacy of S-8184 in Second Line Treatment of Stage III or IV Colorectal Adenocarcinoma | March 2002 | September 2007 |
| NCT06271980 | Completed | Early-Onset Colorectal Cancer Recurrence | April 15, 2023 | February 1, 2024 | |
| NCT02292758 | Completed | Phase 2 | Irinotecan and Cetuximab With or Without Bevacizumab in Treating Patients With RAS Wild-Type Locally Advanced or Metastatic Colorectal Cancer That Cannot Be Removed by Surgery | December 12, 2014 | September 27, 2019 |
| NCT05592873 | Completed | Oncological Impact of Lateral Nodes in Rectal Cancer | January 1, 2014 | September 30, 2022 | |
| NCT05477836 | Completed | N/A | Feasibility and Safety of MiWEndo-assisted Colonoscopy | October 18, 2022 | November 25, 2022 |
| NCT00165217 | Completed | Phase 2 | Capecitabine and Thalidomide in Previously Treated Metastatic Colorectal Carcinoma | November 2001 | December 2005 |
| NCT03706235 | Completed | Colvera for Detection of Disease Recurrence | February 1, 2018 | April 29, 2020 | |
| NCT02835833 | Completed | Phase 1 | Study of Nintedanib Plus Bevacizumab in Advanced Solid Tumors | June 9, 2016 | June 14, 2018 |
| NCT03373188 | Completed | Phase 1 | VX15/2503 and Immunotherapy in Resectable Pancreatic and Colorectal Cancer | December 15, 2017 | October 28, 2021 |
| NCT03958500 | Completed | N/A | The Problem of Colorectal Anastomosis Safety | April 1, 2019 | January 31, 2022 |
| NCT06118658 | Not yet recruiting | Phase 2 | Chemotherapy Sequential Tislelizumab After Radical Resection in Patients With dMMR/MSI-H or POLE/POLD1 Mutations | November 1, 2023 | December 31, 2026 |
| NCT06067620 | Not yet recruiting | N/A | Robotic Right Hemicolectomy Versus Laparoscopic Right Hemicolectomy | August 1, 2024 | December 31, 2026 |
| NCT06225011 | Not yet recruiting | Phase 1 | Fluoxetine for the Modification of Colorectal Tumor Immune Cells Before Surgery in Patients With Colorectal Cancer | June 1, 2024 | June 1, 2026 |
| NCT06342440 | Recruiting | Early Detection of Advanced Adenomas and Colorectal Cancer | March 15, 2020 | December 15, 2025 | |
| NCT02758951 | Recruiting | Phase 2/Phase 3 | Perioperative Systemic Therapy for Isolated Resectable Colorectal Peritoneal Metastases | June 1, 2017 | August 1, 2026 |
| NCT03366155 | Recruiting | Phase 2 | Hepatic Artery Infusion Pump Chemotherapy With Floxuridine and Dexamethasone in Combination With Systemic Chemotherapy for Patients With Colorectal Cancer Metastatic to the Liver | June 24, 2019 | December 30, 2030 |
| NCT03368963 | Recruiting | Phase 1/Phase 2 | TAS102 in Combination With NAL-IRI in Advanced GI Cancers | January 30, 2018 | November 28, 2025 |
| NCT03715933 | Recruiting | Phase 1 | Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas | October 10, 2018 | July 2026 |
| NCT04430127 | Recruiting | The Role of Quantitative Measures on Dual-energy CT in the Prediction of Colorectal Adenocarcinoma | April 1, 2020 | December 31, 2022 | |
| NCT04739072 | Recruiting | Minimal Residual Disease Assessment in Patients With Colorectal Cancer, the MiRDA-C Study | November 22, 2019 | December 31, 2025 | |
| NCT04802876 | Recruiting | Phase 2 | Efficacy of Tislelizumab and Spartalizumab Across Multiple Cancer-types in Patients With PD1-high mRNA Expressing Tumors | April 12, 2021 | March 31, 2027 |
| NCT04870879 | Recruiting | N/A | Colorectal Metastasis and Liver Transplantation With Organs From Deceased Donors | October 1, 2020 | October 2025 |
| NCT05200442 | Recruiting | Phase 1/Phase 2 | A Study of VS-6766 and Cetuximab in Patients With Advanced Colorectal Cancer | August 22, 2022 | August 1, 2025 |
| NCT05247346 | Recruiting | N/A | Early Detection of Cancer Onset Based on Sensing Field Cancerization at the Organ Level in the Alimentary Tract Using an Integrated Stimulated Raman/Scattering Modality for Endoscopic Real-time in Vivo Measurements | July 1, 2022 | December 1, 2024 |
| NCT05411133 | Recruiting | Phase 1 | Treatment of Cabotamig (ARB202) in Advanced Gastrointestinal Cancer Patients | May 30, 2022 | August 2025 |
| NCT05480306 | Recruiting | Phase 2 | Phase 2 Study of DKN-01 in Colorectal Cancer | August 30, 2022 | October 31, 2025 |
| NCT05504252 | Recruiting | Phase 2 | METIMMOX-2: Metastatic pMMR/MSS Colorectal Cancer - Shaping Anti-Tumor Immunity by Oxaliplatin | October 5, 2022 | December 30, 2027 |
| NCT05620134 | Recruiting | Phase 1/Phase 2 | Study of JK08 in Patients With Unresectable Locally Advanced or Metastatic Cancer | October 17, 2022 | February 20, 2026 |
| NCT05635149 | Recruiting | Predictive Factors for Outcomes of Fruquintinib Plus Immunotherapy in Colorectal Cancer | January 1, 2022 | September 30, 2023 | |
| NCT05731271 | Recruiting | Phase 1/Phase 2 | A First-in-Human, Phase 1 Study of TST003 in Subjects With Solid Tumors | February 8, 2023 | August 2025 |
| NCT05736731 | Recruiting | Phase 1/Phase 2 | A Study to Evaluate the Safety and Efficacy of A2B530, a Logic-gated CAR T, in Subjects With Solid Tumors That Express CEA and Have Lost HLA-A*02 Expression | April 28, 2023 | December 2028 |
| NCT05902988 | Recruiting | Phase 1/Phase 2 | A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer | October 18, 2023 | June 2026 |
| NCT05988645 | Recruiting | N/A | Performance and Safety of MiWEndo-assisted Colonoscopy (MiWEndo II) | August 1, 2023 | December 29, 2024 |
| NCT06050447 | Recruiting | Factors Affecting the Results of Treatment of Patients With Colorectal Cancer | September 1, 2023 | September 1, 2026 | |
| NCT06051695 | Recruiting | Phase 1/Phase 2 | A Study to Evaluate the Safety and Efficacy of A2B694, a Logic-gated CAR T, in Subjects With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression | April 3, 2024 | June 2029 |
| NCT06076811 | Recruiting | DANISH.MRD: Danish Assessment of Minimal Residual Disease by Liquid Biopsies | August 1, 2023 | July 30, 2030 | |
| NCT06134440 | Recruiting | N/A | ImmunoNutrition and Colorectal Adenocarcinoma Surgery - INCAS Study | November 21, 2023 | September 2025 |
| NCT06314958 | Recruiting | Stage II/III Colorectal Cancer Recurrence | March 15, 2023 | March 15, 2025 | |
| NCT06314971 | Recruiting | Predicting Local and Distant Recurrence in T1 Colorectal Cancer | March 15, 2023 | March 15, 2025 | |
| NCT06342401 | Recruiting | Early Onset Colorectal Cancer Detection | April 15, 2023 | October 15, 2025 | |
| NCT04111172 | Suspended | Phase 2 | A Vaccine (Ad5.F35-hGCC-PADRE) for the Treatment of Gastrointestinal Adenocarcinoma | November 10, 2020 | December 31, 2024 |
| NCT04108481 | Suspended | Phase 1/Phase 2 | Immunotherapy With Y90-RadioEmbolization for Metastatic Colorectal Cancer | October 5, 2020 | December 31, 2025 |
| NCT01367275 | Terminated | Phase 2 | Irinotecan Plus Brivanib in Metastatic Colorectal Cancer (CRC) Enriched for Elevated Levels of Plasma FGF | August 2011 | November 2013 |
| NCT02709811 | Terminated | Phase 1/Phase 2 | Safety and Feasibility of Electrochemotherapy in Unresectable Colorectal Adenocarninoma Liver Metastases | August 2012 | January 2015 |
| NCT03050814 | Terminated | Phase 2 | Standard of Care Alone or in Combination With Ad-CEA Vaccine and Avelumab in People With Previously Untreated Metastatic Colorectal Cancer QUILT-2.004 | April 5, 2017 | August 25, 2021 |
| NCT01114256 | Terminated | FNA Tumor Sampling for CD137 Modulation: A Pilot Study | March 2010 | January 2016 | |
| NCT01844076 | Terminated | Phase 1/Phase 2 | Quinacrine-Capecitabine Combinatorial Therapy for Advanced Stage Colorectal Adenocarcinoma | January 14, 2016 | August 9, 2019 |
| NCT02650635 | Terminated | Phase 1 | TLR8 Agonist VTX-2337 and Cyclophosphamide in Treating Patients With Metastatic, Persistent, Recurrent, or Progressive Solid Tumors | February 5, 2016 | June 1, 2017 |
| NCT01856322 | Terminated | Phase 2 | Surgery Plus Sulindac or Surgery Alone for Advanced Colorectal Cancer | April 2013 | January 2015 |
| NCT03781778 | Terminated | Phase 2 | Pilot Trial of Resistant Starch in Stage I-III Colorectal Cancer Survivors | May 7, 2019 | October 1, 2020 |
| NCT02757391 | Terminated | Phase 1 | CD8+ T Cell Therapy and Pembrolizumab in Treating Patients With Metastatic Gastrointestinal Tumors | August 9, 2019 | October 2, 2020 |
| NCT02638909 | Terminated | Phase 2 | Study of Oral Ceritinib in Patients With ALK and ROS1 Activated Gastrointestinal Malignancies | December 2015 | March 29, 2018 |
| NCT03300609 | Terminated | Phase 3 | 5-FU Based Maintenance Therapy in RAS Wild Type Metastatic Colorectal Cancer After Induction With FOLFOX Plus Panitumumab | February 27, 2018 | October 3, 2019 |
| NCT04894123 | Terminated | Phase 2 | Cardiovascular Events From Trifluridine/Tipiracil +/- Oxaliplatin in Colorectal/Oesogastric Adenocarcinoma Patients | February 7, 2022 | February 13, 2023 |
| NCT03376659 | Terminated | Phase 1/Phase 2 | Durvalumab Plus CV301 With Maintenance Chemotherapy in Metastatic Colorectal or Pancreatic Adenocarcinoma | August 8, 2018 | August 1, 2023 |
| NCT01552967 | Unknown status | Phase 2 | Efficacy and Safety Study of a Modified XELOX Regimen in First-Line Treatment of Metastatic Colorectal Adenocarcinoma | March 2012 | February 2014 |
| NCT03699163 | Unknown status | The Colorectal Breath Analysis (COBRA) Study | June 3, 2017 | April 30, 2022 | |
| NCT03507998 | Unknown status | Phase 1 | Phase 1 Dose Escalation Study of CGX1321 in Subjects With Advanced Gastrointestinal Tumors | June 17, 2017 | April 1, 2021 |
| NCT03803891 | Unknown status | Endoscopic Full-Thickness Resection In Colon | May 1, 2018 | July 31, 2020 | |
| NCT03468244 | Unknown status | N/A | Clinical Study of Personalized mRNA Vaccine Encoding Neoantigen in Patients With Advanced Digestive System Neoplasms | May 1, 2018 | December 31, 2021 |
| NCT04148378 | Unknown status | A Pilot Study to Explore the Role of Gut Flora in Colorectal Cancer | March 2, 2020 | July 2023 | |
| NCT04196088 | Unknown status | N/A | To Compare Artificial Intelligence Software Aided Adenoma Detection in Screening Colonoscopies Versus Standard Colonoscopy Without Artificial Intelligence Software Assistance in Participants Between 45 and 75 Years of Age | June 11, 2020 | December 2021 |
| NCT04380103 | Unknown status | Phase 1/Phase 2 | A Phase I/II Study of XELOXIRI and Bevacizumab as First-line Treatment in Metastatic Colorectal Cancer | April 26, 2020 | September 2022 |
| NCT03221920 | Unknown status | N/A | Very Low Carbohydrate Diet Effects to GPS, Serum Lactate and TNF Alpha on Colorectal Cancer | August 5, 2017 | August 30, 2017 |
| NCT03149523 | Unknown status | Exhaustive Genetic and Immunological Characterization of Colon, Kidney and Liver Tumors | May 2017 | April 2019 | |
| NCT04773769 | Unknown status | N/A | Study of Guanábana Leaves for The Treatment of Patients With Gastric, Gastroesophageal Junction, Pancreatic and Colorectal Adenocarcinomas; Hepatocellular Carcinoma, and Low Grade Lymphomas | November 7, 2018 | November 2023 |
| NCT03708536 | Withdrawn | Phase 3 | Bevacizumab Plus Capecitabin vs S-1 as Maintenance Treatment Following First-line Chemotherapy in the Patients With Advanced Colorectal Adenocarcinoma | November 2018 | November 2022 |
| NCT04054752 | Withdrawn | Phase 1 | Vaccine Response With NT-I7 | May 30, 2023 | November 1, 2023 |
| NCT02413853 | Withdrawn | Phase 2 | Combination Chemotherapy and Bevacizumab With or Without PRI-724 in Treating Patients With Newly Diagnosed Metastatic Colorectal Cancer | November 2015 | November 2018 |
| NCT03576963 | Withdrawn | Phase 1/Phase 2 | Guadecitabine and Nivolumab in Treating Refractory Metastatic Colorectal Cancer | January 30, 2020 | January 30, 2023 |
- Disase is a (Disease Ontology)
- DOID:0080199
- Cross Reference ID (Disease Ontology)
- NCI:C5105
- Cross Reference ID (Disease Ontology)
- SNOMEDCT_US_2023_03_01:408645001
- Cross Reference ID (Disease Ontology)
- UMLS_CUI:C1319315