Annotation Detail

Information

Associated Genes: ERBB2
Associated Variants: ERBB2 p.Leu755Ser (p.L755S) ( ENST00000269571.10, ENST00000406381.6, ENST00000445658.6, ENST00000541774.5, ENST00000584450.5, ENST00000584601.5 )
ERBB2 p.Leu755Ser (p.L755S) ( ENST00000269571.10, ENST00000406381.6, ENST00000445658.6, ENST00000541774.5, ENST00000584450.5, ENST00000584601.5 )
Associated Disease: colorectal adenocarcinoma
Source Database: CIViC Evidence
Description: Patient was a 35 year old male who was treated with pseudoadjuvant FOLFOX chemotherapy. Patient relapsed and was found to have an ERBB2 L755S kinase domain mutation along with mutations in APC and BRAF. He was then treated with trastuzumab combined with infusional 5-Fu and leucovorin but exhibited no response.
Variant Origin: somatic
Variant Origin: Somatic
Evidence URL: https://civic.genome.wustl.edu/links/evidence_items/4955
Gene URL: https://civic.genome.wustl.edu/links/genes/20
Variant URL: https://civic.genome.wustl.edu/links/variants/39
Rating: 3
Evidence Type: Predictive
Disease: Colorectal Adenocarcinoma
Evidence Direction: Does Not Support
Drug: Leucovorin,Fluorouracil,Trastuzumab
Evidence Level: C
Clinical Significance: Sensitivity/Response
Pubmed: 27626067

Drugs