Annotation Detail
Information
- Associated Genes
- TYMS
- Associated Variants
-
TYMS 5' TANDEM REPEAT
TYMS 5' TANDEM REPEAT - Associated Disease
- colorectal cancer
- Source Database
- CIViC Evidence
- Description
- The TYMS 5' 3TPR germline variant was significantly correlated with lower response to irinotecan plus 5-fluorouracil treatment in colorectal cancer patients. 149 metastatic CRC patients treated with irinotecan/5FU as first-line chemotherapy were followed in this study.
- Variant Origin
- germline
- Variant Origin
- Rare Germline
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/678
- Gene URL
- https://civic.genome.wustl.edu/links/genes/5971
- Variant URL
- https://civic.genome.wustl.edu/links/variants/265
- Rating
- 3
- Evidence Type
- Predictive
- Disease
- Colorectal Cancer
- Evidence Direction
- Supports
- Drug
- Fluorouracil,Irinotecan
- Evidence Level
- B
- Clinical Significance
- Resistance
- Pubmed
- 20628391
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Fluorouracil | Resitance or Non-Reponse | true |
| Irinotecan | Resitance or Non-Reponse | true |