Annotation Detail
Information
- Associated Genes
- HSPH1
- Associated Variants
-
HSPH1 NUCLEAR EXPRESSION
HSPH1 NUCLEAR EXPRESSION - Associated Disease
- gastric adenocarcinoma
- Source Database
- CIViC Evidence
- Description
- 49 patients gastric cancer patients treated with adjuvant chemotherapy were immunohistochemically assessed for nuclear HSPH1 (HSP110) expression. Overall survival rate in the high expression group (2+ moderate/3+ strong staining) was significantly lower compared with the low expression group (0 no/1+ weak staining) (P = 0.0364). In gastric cancer cell lines (MKN7, MKN45), siRNA mediated HSP110 knockdown led to a higher sensitivity to 5-FU and cisplatin compared with the parent and control cells (p < 0.05).
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/1163
- Gene URL
- https://civic.genome.wustl.edu/links/genes/8614
- Variant URL
- https://civic.genome.wustl.edu/links/variants/490
- Rating
- 1
- Evidence Type
- Predictive
- Disease
- Gastric Adenocarcinoma
- Evidence Direction
- Supports
- Drug
- Cisplatin,Fluorouracil
- Evidence Level
- D
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 26943774
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Cisplatin | Sensitivity | true |
| Fluorouracil | Sensitivity | true |