Annotation Detail

Information

Associated Genes: DKK1
Associated Variants: DKK1 NUCLEAR EXPRESSION
DKK1 NUCLEAR EXPRESSION
Associated Disease: colorectal cancer
Source Database: CIViC Evidence
Description: Nuclear expression of DICKKOPF-1 was identified in 15% of 699 patients with colorectal cancer and was associated with decreased progression-free survival (PFS) and overall survival (OS) after chemotherapy (FOLFOX, FOLFIRI, or 5-FU) [adjusted HR, 1.65; 95% confidence interval (CI), 1.23-2.21; P = 0.002)].
Variant Origin: N/A
Variant Origin: N/A
Evidence URL: https://civic.genome.wustl.edu/links/evidence_items/824
Gene URL: https://civic.genome.wustl.edu/links/genes/9171
Variant URL: https://civic.genome.wustl.edu/links/variants/340
Rating: 3
Evidence Type: Predictive
Disease: Colorectal Cancer
Evidence Direction: Supports
Drug: Fluorouracil,Oxaliplatin,Levoleucovorin,Irinotecan
Evidence Level: B
Clinical Significance: Resistance
Pubmed: 25788273

Drugs