Annotation Detail

Information

Associated Genes: DPYD
Associated Variants: DPYD c.1905+1G>A ( ENST00000370192.8 )
DPYD c.1905+1G>A ( ENST00000370192.8 )
Associated Disease: cancer
Source Database: CIViC Evidence
Description: The Clinical Pharmacogenomics Implementation Consortium Guidelines for DPYD genotype and 5-FU dosing does not recommend the use of 5-FU or capecitabine in patients with homozygous DPYD*2A, *13 or rs67376798 and the FDA drug labels warn to use precautions in this patient population.
Variant Origin: Common Germline
Variant Origin: Common Germline
Evidence URL: https://civic.genome.wustl.edu/links/evidence_items/1800
Gene URL: https://civic.genome.wustl.edu/links/genes/1526
Variant URL: https://civic.genome.wustl.edu/links/variants/737
Rating: 5
Evidence Type: Predictive
Disease: Cancer
Evidence Direction: Supports
Drug: Tegafur,Fluorouracil,Capecitabine
Evidence Level: A
Clinical Significance: Adverse Response
Pubmed: 23988873

Drugs