Annotation Detail
Information
- Associated Genes
- EGFR
- Associated Variants
-
EGFR AMPLIFICATION
(
ENST00000275493.7 )
EGFR AMPLIFICATION ( ENST00000275493.7 ) - Associated Disease
- head and neck squamous cell carcinoma
- Source Database
- CIViC Evidence
- Description
- EGFR amplification was not a predictor of response to cetuximab/5-FU/platinum in patients with recurrent or metastatic HNSSC from the EXTREME study.
- Variant Origin
- somatic
- Variant Origin
- Somatic
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/691
- Gene URL
- https://civic.genome.wustl.edu/links/genes/19
- Variant URL
- https://civic.genome.wustl.edu/links/variants/190
- Rating
- 4
- Evidence Type
- Predictive
- Disease
- Head And Neck Squamous Cell Carcinoma
- Evidence Direction
- Does Not Support
- Drug
- Fluorouracil,Platinum Compound,Cetuximab
- Evidence Level
- B
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 21048039
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Cetuximab | Sensitivity | false |
| Fluorouracil | Sensitivity | false |
| Platinum Compound | Sensitivity | false |