Annotation Detail
Information
- Associated Genes
- VEGFA
- Associated Variants
-
VEGFA UNDEREXPRESSION
(
ENST00000372055.9 )
VEGFA UNDEREXPRESSION ( ENST00000372055.9 ) - Associated Disease
- colorectal cancer
- Source Database
- CIViC Evidence
- Description
- Decreased peri- and post-therapeutic expression of VEGFA were significantly associated with response to FOLFIRI plus bevacizumab in 57 patients with metastatic CRC.
- Variant Origin
- N/A
- Variant Origin
- N/A
- Evidence URL
- https://civic.genome.wustl.edu/links/evidence_items/818
- Gene URL
- https://civic.genome.wustl.edu/links/genes/6071
- Variant URL
- https://civic.genome.wustl.edu/links/variants/334
- Rating
- 2
- Evidence Type
- Predictive
- Disease
- Colorectal Cancer
- Evidence Direction
- Supports
- Drug
- Irinotecan,Fluorouracil,Levoleucovorin,Bevacizumab
- Evidence Level
- B
- Clinical Significance
- Sensitivity/Response
- Pubmed
- 25973082
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Bevacizumab | Sensitivity | true |
| Fluorouracil | Sensitivity | true |
| Irinotecan | Sensitivity | true |
| Levoleucovorin | Sensitivity | true |