chr12:72332625:> Detail (hg19)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr12:72,332,625-72,426,220 |
| hg38 | chr12:71,938,845-72,032,440 |
HGVS
| Type | Transcript | Protein |
|---|---|---|
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
Frequency
[No Data.]
Prediction
[No Data.]
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
| Score | Disease name | Description | Source | Pubmed | Links |
|---|---|---|---|---|---|
| <0.001 | dental enamel hypoplasia | NA | BeFree | Detail | |
| 0.028 | Mental Depression | Tryptophan hydroxylase 2 gene is associated with cognition in late-onset depress... | BeFree,GAD | 26057341 | Detail |
| <0.001 | diarrhea | NA | BeFree | Detail | |
| <0.001 | Drug abuse | Rs7305115 (TPH2) revealed significant effects in SNP × abuse and SNP × SNP as we... | BeFree | 25214390 | Detail |
| <0.001 | Eating Disorders | NA | BeFree | Detail | |
| <0.001 | Epilepsy, Temporal Lobe | Tryptophan hydroxylase 2 (TPH2) gene polymorphisms and psychiatric comorbidities... | BeFree | 24491795 | Detail |
| <0.001 | Fatigue | NA | BeFree | Detail | |
| 0.007 | chronic fatigue syndrome | NA | GAD | Detail | |
| 0.120 | Fever | NA | CTD_human | Detail | |
| <0.001 | Atrial Septal Defects | NA | BeFree | Detail | |
| 0.003 | heroin dependence | NA | BeFree,GAD | Detail | |
| <0.001 | Hyperphagia | NA | BeFree | Detail | |
| <0.001 | irritable bowel syndrome | NA | BeFree | Detail | |
| 0.002 | liver cirrhosis | NA | GAD | Detail | |
| <0.001 | Malabsorption Syndrome | NA | BeFree | Detail | |
| <0.001 | Metabolic Diseases | NA | BeFree | Detail | |
| 0.003 | Mucocutaneous Lymph Node Syndrome | NA | BeFree,GAD | Detail | |
| <0.001 | muscular dystrophy | NA | BeFree | Detail | |
| 0.001 | obsessive-compulsive disorder | NA | BeFree | Detail | |
| <0.001 | osteochondritis dissecans | NA | BeFree | Detail | |
| 0.014 | panic disorder | NA | BeFree,GAD,LHGDN | Detail | |
| <0.001 | Personality Disorders | NA | BeFree | Detail | |
| <0.001 | Pituitary Diseases | NA | BeFree | Detail | |
| <0.001 | Prader-Willi syndrome | NA | BeFree | Detail | |
| 0.002 | Prenatal Exposure Delayed Effects | NA | GAD | Detail | |
| 0.002 | Psychophysiologic Disorders | NA | GAD | Detail | |
| 0.005 | schizophrenia | NA | BeFree,GAD | Detail | |
| <0.001 | paranoid schizophrenia | NA | BeFree | Detail | |
| <0.001 | post-traumatic stress disorder | TPH2 genotype is associated with PTSD's avoidance symptoms in Chinese female ear... | BeFree | 25014617 | Detail |
| <0.001 | Stress Disorders, Traumatic | NA | BeFree | Detail | |
| <0.001 | Stress, Psychological | NA | BeFree | Detail | |
| 0.005 | sudden infant death syndrome | NA | GAD,LHGDN | Detail | |
| 0.005 | Tobacco use disorder | NA | GAD | Detail | |
| 0.003 | Gilles de la Tourette syndrome | NA | LHGDN | Detail | |
| 0.007 | Unipolar Depression | Lack of association between TPH2 gene polymorphisms with major depressive disord... | BeFree | 24376086 | Detail |
| 0.007 | Unipolar Depression | Accumulating evidences suggest that Tryptophan hydroxylase 2 (TPH2) gene is asso... | BeFree | 26057341 | Detail |
| 0.002 | Weight Gain | NA | GAD | Detail | |
| <0.001 | Mood swings | NA | BeFree | Detail | |
| 0.001 | Depressive Symptoms | NA | BeFree | Detail | |
| <0.001 | Small cell carcinoma of lung | NA | BeFree | Detail | |
| 0.005 | Migraine Disorders | NA | BeFree,GAD | Detail | |
| <0.001 | osteochondritis dissecans | Five SNPs achieved 0.004 (the nominal p-value expected by chance), 3 with empiri... | BeFree | 23337130 | Detail |
| 0.001 | obsessive-compulsive disorder | Five SNPs achieved 0.004 (the nominal p-value expected by chance), 3 with empiri... | BeFree | 23337130 | Detail |
| <0.001 | Self-induced vomiting | NA | BeFree | Detail | |
| 0.005 | Personality Traits | NA | GAD | Detail | |
| <0.001 | Fibrosis, Liver | NA | BeFree | Detail | |
| 0.127 | depressive disorder | Six functional SNPs in genes related to the serotonergic system were examined: s... | BeFree | 20515362 | Detail |
| 0.028 | Mental Depression | Six functional SNPs in genes related to the serotonergic system were examined: s... | BeFree | 20515362 | Detail |
| <0.001 | Common Migraine | NA | BeFree | Detail | |
| <0.001 | Mixed anxiety and depressive disorder | NA | BeFree | Detail | |
| <0.001 | Ichthyosis bullosa of Siemens | NA | BeFree | Detail | |
| 0.003 | Metabolic syndrome X | NA | BeFree,GAD | Detail | |
| <0.001 | Neurobehavioral Manifestations | NA | BeFree | Detail | |
| 0.005 | Mood Disorders | NA | BeFree,LHGDN | Detail | |
| 0.003 | cocaine dependence | NA | BeFree,GAD | Detail | |
| 0.002 | hepatopulmonary syndrome | NA | GAD | Detail | |
| <0.001 | Hashimoto Disease | NA | BeFree | Detail | |
| <0.001 | depression anxiety disorder | NA | BeFree | Detail | |
| <0.001 | perfectionism | NA | BeFree | Detail | |
| 0.001 | Completed Suicide | NA | BeFree | Detail | |
| <0.001 | bipolar I disorder | NA | BeFree | Detail | |
| <0.001 | Adult attention deficit hyperactivity disorder | NA | BeFree | Detail | |
| 0.211 | major depressive disorder | Lack of association between TPH2 gene polymorphisms with major depressive disord... | BeFree,CTD_human,GAD,MGD | 24376086 | Detail |
| 0.211 | major depressive disorder | Accumulating evidences suggest that Tryptophan hydroxylase 2 (TPH2) gene is asso... | BeFree,CTD_human,GAD,MGD | 26057341 | Detail |
| <0.001 | Autism Spectrum Disorders | NA | BeFree | Detail | |
| <0.001 | Depression and Suicide | NA | BeFree | Detail | |
| <0.001 | MAJOR AFFECTIVE DISORDER 2 | NA | BeFree | Detail | |
| <0.001 | NEUROTICISM | Significant association of the TPH2 genotype with Neuroticism and Conscientiousn... | BeFree | 25455586 | Detail |
| <0.001 | COGNITIVE FUNCTION 1, SOCIAL | NA | BeFree | Detail | |
| <0.001 | MAJOR AFFECTIVE DISORDER 1 | NA | BeFree | Detail | |
| 0.001 | PANIC DISORDER 1 | NA | BeFree | Detail | |
| <0.001 | MAJOR AFFECTIVE DISORDER 4 | NA | BeFree | Detail | |
| <0.001 | MAJOR AFFECTIVE DISORDER 5 | NA | BeFree | Detail | |
| <0.001 | MAJOR AFFECTIVE DISORDER 6 | NA | BeFree | Detail | |
| <0.001 | Loose stool | NA | BeFree | Detail | |
| <0.001 | Major affective disorder 7 | NA | BeFree | Detail | |
| <0.001 | MAJOR AFFECTIVE DISORDER 8 | NA | BeFree | Detail | |
| <0.001 | MAJOR AFFECTIVE DISORDER 9 | NA | BeFree | Detail | |
| 0.002 | Weight Gain Adverse Event | NA | GAD | Detail | |
| <0.001 | agoraphobia | NA | BeFree | Detail | |
| <0.001 | alcohol use disorder | NA | BeFree | Detail | |
| 0.011 | Alcoholic Intoxication, Chronic | Genetic variability in tryptophan hydroxylase 2 gene in alcohol dependence and a... | BeFree,GAD | 26232682 | Detail |
| <0.001 | anorexia nervosa | NA | BeFree | Detail | |
| 0.002 | As If Personality | NA | GAD | Detail | |
| 0.135 | autistic disorder | NA | BeFree,CTD_human,GAD | Detail | |
| 0.003 | Mental disorders | NA | BeFree | Detail | |
| 0.021 | bipolar disorder | Association study of TPH2 polymorphisms and bipolar disorder in the Han Chinese ... | BeFree,GAD,LHGDN | 25152196 | Detail |
| 0.001 | borderline personality disorder | The aim of this study was to examine the association between the polymorphisms i... | BeFree | 25152196 | Detail |
| <0.001 | bronchopulmonary dysplasia | The aim of this study was to examine the association between the polymorphisms i... | BeFree | 25152196 | Detail |
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| NA | DisGeNET | Detail |
| Tryptophan hydroxylase 2 gene is associated with cognition in late-onset depression in a Chinese Han... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Rs7305115 (TPH2) revealed significant effects in SNP × abuse and SNP × SNP as well as in the three-w... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Tryptophan hydroxylase 2 (TPH2) gene polymorphisms and psychiatric comorbidities in temporal lobe ep... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| TPH2 genotype is associated with PTSD's avoidance symptoms in Chinese female earthquake survivors. | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Lack of association between TPH2 gene polymorphisms with major depressive disorder in multiethnic Ma... | DisGeNET | Detail |
| Accumulating evidences suggest that Tryptophan hydroxylase 2 (TPH2) gene is associated with major de... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Five SNPs achieved 0.004 (the nominal p-value expected by chance), 3 with empirical significant p-va... | DisGeNET | Detail |
| Five SNPs achieved 0.004 (the nominal p-value expected by chance), 3 with empirical significant p-va... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Six functional SNPs in genes related to the serotonergic system were examined: serotonin transporter... | DisGeNET | Detail |
| Six functional SNPs in genes related to the serotonergic system were examined: serotonin transporter... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Lack of association between TPH2 gene polymorphisms with major depressive disorder in multiethnic Ma... | DisGeNET | Detail |
| Accumulating evidences suggest that Tryptophan hydroxylase 2 (TPH2) gene is associated with major de... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Significant association of the TPH2 genotype with Neuroticism and Conscientiousness was found at age... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Genetic variability in tryptophan hydroxylase 2 gene in alcohol dependence and alcohol-related psych... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Association study of TPH2 polymorphisms and bipolar disorder in the Han Chinese population. | DisGeNET | Detail |
| The aim of this study was to examine the association between the polymorphisms in TPH2 and BPD. | DisGeNET | Detail |
| The aim of this study was to examine the association between the polymorphisms in TPH2 and BPD. | DisGeNET | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- dbSNP
- rs1074815 dbSNP
- Genome
- hg19
- Position
- chr12:72,332,625-72,426,220
- Variant Type
- snv
Genome browser