MGMT UNDEREXPRESSION Detail (hg19) (MGMT)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr10:131,265,454-131,569,247 |
| hg38 | chr10:129,467,190-129,770,983 |
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
| Type | Database | ID | Link |
|---|---|---|---|
| Gene | MIM | ||
| HGNC | |||
| Ensembl | |||
| NCBI | |||
| Gene Cards | |||
| OncoKB |
| Type | Database | ID | Link |
|---|---|---|---|
| Variant | TogoVar | ||
| COSMIC | |||
| MONDO |
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
[No Data.]
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| MGMT gene (not promoter) demethylation by 5-AZA inhibits MGMT expression, which increases the therap... | MMMP | Detail |
| Acquired resistance to fotemustine was alleviated by treatment with the MGMT inhibitor O6-benzylguan... | MMMP | Detail |
| BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) is a chloroethylnitrosourea | MMMP | Detail |
| Cystemustine is a chloroethylnitrosourea | MMMP | Detail |
| MGMT causes resistance to TMZ | MMMP | Detail |
| Inhibition of MGMT with O6-benzylguanine resulted in decrease in cell viability and this correlated ... | MMMP | Detail |
| 4BTG was less toxic (but equally effective) than O6-benzylguanine | MMMP | Detail |
| MGMT inactivation by O(6)-benzylguanine sensitized all melanoma cell lines expressing MGMT to TMZ an... | MMMP | Detail |
| MGMT inactivation by O(6)-benzylguanine sensitized all melanoma cell lines expressing MGMT to TMZ an... | MMMP | Detail |
| Coincubation of melanoma cells with O6-benzylguanine significantly increased the cytotoxicity of fot... | MMMP | Detail |
| IBgBZ is designed as a conjugate of O(6)-(4-iododbenzyl)guanine (IBg) as the MGMT inactivator and a ... | MMMP | Detail |
| Isolated limb infusion model (locoregional therapy) | MMMP | Detail |
| Interleukin-24 overcomes temozolomide resistance and enhances cell death by downregulation of O6-met... | MMMP | Detail |
| In this phase I study of extended dosing with lomeguatrib with TMZ in patients with advanced melanom... | MMMP | Detail |
| RCT of the combination of lomeguatrib and temozolomide compared with temozolomide alone in chemother... | MMMP | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- Genome
- hg19
- Position
- chr10:131,265,454-131,569,247
- Variant Type
- cnv
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