Annotation Detail
Information
- Associated Genes
- MGMT
- Associated Variants
- MGMT UNDEREXPRESSION
- Source Database
- MMMP
- Description
- In this phase I study of extended dosing with lomeguatrib with TMZ in patients with advanced melanoma, only limited clinical activity was seen, suggesting no advantage for this regimen over conventional TMZ administration in the treatment of melanoma
- MMMP State
- inhibited by
- MMMP Molecule
- MGMT
- MMMP Molecule Alias
- O-6-methylguanine-DNA methyltransferase
- MMMP Modifier
- Lomeguatrib
- MMMP Relationship
- no relationship with
- MMMP Drug
- Temozolomide
- MMMP Drug Alias
- TMZ
- MMMP Model
- 5
- MMMP Reference
- Kefford RF, Br J Cancer 2009, 100:1245-9
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Temozolomide | Resitance or Non-Reponse | true |