Annotation Detail
Information
- Associated Genes
- MGMT
- Associated Variants
- MGMT UNDEREXPRESSION
- Source Database
- MMMP
- Description
- Acquired resistance to fotemustine was alleviated by treatment with the MGMT inhibitor O6-benzylguanine demonstrating that reactivation of MGMT is the main underlying cause of acquired alkylating drug resistance
- MMMP State
- inhibited by
- MMMP Molecule
- MGMT
- MMMP Molecule Alias
- O-6-methylguanine-DNA methyltransferase
- MMMP Modifier
- O-6-benzylguanidine
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Fotemustine
- MMMP Model
- 3
- MMMP Reference
- Christmann M, Int J Cancer 2001, 92:123-9
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Fotemustine | Sensitivity | true |