Annotation Detail
Information
- Associated Genes
- MGMT
- Associated Variants
- MGMT UNDEREXPRESSION
- Source Database
- MMMP
- Description
- MGMT inactivation by O(6)-benzylguanine sensitized all melanoma cell lines expressing MGMT to TMZ and fotemustine-induced apoptosis, and MGMT transfection attenuated the apoptotic response
- MMMP State
- inhibited by
- MMMP Molecule
- MGMT
- MMMP Molecule Alias
- O-6-methylguanine-DNA methyltransferase
- MMMP Modifier
- O-6-benzylguanidine
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Fotemustine
- MMMP Model
- 3
- MMMP Reference
- Naumann SC, Br J Cancer 2009, 100:322-33
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Fotemustine | Sensitivity | true |