Annotation Detail
Information
- Associated Genes
- MGMT
- Associated Variants
- MGMT UNDEREXPRESSION
- Source Database
- MMMP
- Description
- MGMT gene (not promoter) demethylation by 5-AZA inhibits MGMT expression, which increases the therapeutic effect of fotemustine
- MMMP State
- downregulated by
- MMMP Molecule
- MGMT
- MMMP Molecule Alias
- O-6-methylguanine-DNA methyltransferase
- MMMP Modifier
- 5-azacytidine
- MMMP Modifier Alias
- 5-AZA
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Fotemustine
- MMMP Model
- 3
- MMMP Reference
- Christmann M, Int J Cancer 2001, 92:123-9
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Fotemustine | Sensitivity | true |