Annotation Detail
Information
- Associated Genes
- MGMT
- Associated Variants
- MGMT UNDEREXPRESSION
- Source Database
- MMMP
- Description
- Inhibition of MGMT with O6-benzylguanine resulted in decrease in cell viability and this correlated with western blot analysis of MGMT levels in the melanoma cells
- MMMP State
- inhibited by
- MMMP Molecule
- MGMT
- MMMP Molecule Alias
- O-6-methylguanine-DNA methyltransferase
- MMMP Modifier
- O-6-benzylguanidine
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Temozolomide
- MMMP Drug Alias
- TMZ
- MMMP Model
- 3
- MMMP Reference
- Mhaidat NM, Br J Cancer 2007, 97:1225-33
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Temozolomide | Sensitivity | true |