chr15:75012985:T>G Detail (hg19) (CYP1A1)

Information

Genome

Assembly Position
hg19 chr15:75,012,985-75,012,985
hg38 chr15:74,720,644-74,720,644 View the variant detail on this assembly version.

HGVS

Type Transcript Protein
RefSeq NM_001319216.1:c.1297A>C NP_001306145.1:p.Ile433Leu
NM_000499.4:c.1384A>C NP_000490.1:p.Ile462Leu
NM_001319217.1:c.1384A>C NP_001306146.1:p.Ile462Leu
Summary

MGeND

Clinical significance
Variant entry
GWAS entry
Disease area statistics Show details

Frequency

[No Data.]

Prediction

ClinVar

Clinical Significance
Review star [No Data.]
Show details
Links
Type Database ID Link
Gene MIM 108330 OMIM
HGNC 2595 HGNC
Ensembl ENSG00000140465 Ensembl
NCBI NCBI
Gene Cards Gene Cards
OncoKB OncoKB
Type Database ID Link
Variant TogoVar
COSMIC
MONDO
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score Disease name Description Source Pubmed Links
0.002 Malignant neoplasm of gallbladder These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and t... BeFree 17531965 Detail
0.080 breast carcinoma The increased risk of breast cancer associated with E+P use was greater among wo... BeFree 18628428 Detail
0.132 Malignant neoplasm of breast The increased risk of breast cancer associated with E+P use was greater among wo... BeFree 18628428 Detail
0.104 Malignant neoplasm of breast The increased risk of breast cancer associated with E+P use was greater among wo... BeFree 18628428 Detail
0.024 breast carcinoma The increased risk of breast cancer associated with E+P use was greater among wo... BeFree 18628428 Detail
0.001 vascular disease occlusive All subjects were genotyped for 13 polymorphic variants in the genes of xenobiot... BeFree 23107763 Detail
0.337 hyperhomocysteinemia All subjects were genotyped for 13 polymorphic variants in the genes of xenobiot... BeFree 23107763 Detail
<0.001 hyperhomocysteinemia All subjects were genotyped for 13 polymorphic variants in the genes of xenobiot... BeFree 23107763 Detail
0.146 Homocysteinemia All subjects were genotyped for 13 polymorphic variants in the genes of xenobiot... BeFree 23107763 Detail
<0.001 Homocysteinemia All subjects were genotyped for 13 polymorphic variants in the genes of xenobiot... BeFree 23107763 Detail
0.001 Ovarian Diseases However, further studies are still needed to accurately determine whether the CY... BeFree 23848208 Detail
0.124 Malignant neoplasm of lung We examined an Ile462Val polymorphism (CYP1A1*2 allele) of cytochrome P450 IA1 i... BeFree 9610791 Detail
<0.001 Adenocarcinoma of lung (disorder) Furthermore, the combination of risk genotypes of CYP1B1 Leu432Val with CYP1A1 I... BeFree 17980933 Detail
0.044 Malignant neoplasm of lung CYP1A1 rs4646903 (OR = 1.72, 95% CI = 1.25-2.38), rs1048943 (OR = 1.40, 95% CI =... BeFree 22525558 Detail
0.072 colorectal cancer Relationship between genetic polymorphism of CYP1A1 at codon 462 (Ile462Val) in ... BeFree 18409146 Detail
<0.001 Lymphoma, Large-Cell, Follicular Our data provide evidence that the GSTP1 rs1695 and the CYP1A1 rs1048943 genotyp... BeFree 19899130 Detail
0.002 Non-small cell lung carcinoma In this study, CYP1A1 (Ile462Val), CYP1B1(Asn453Ser), GST M1, GSTP1 exon 5 (Ile1... BeFree 20845989 Detail
0.097 Malignant neoplasm of breast We examined the potential association of breast cancer risk in Mexican women wit... BeFree 23000097 Detail
0.005 cervix carcinoma (2) rs1048943 (CYP1A1 A4889G) showed the strongest association with cervical can... BeFree 25928231 Detail
0.014 adenocarcinoma CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but ... BeFree 16195240 Detail
0.001 Uterine Fibroids The genetic polymorphism of rs3087869 (IVS1+2329C&gt;T) (OR 3.200, 95% CI 1.614-... BeFree 24777039 Detail
0.007 Carcinoma of lung CYP1A1 rs4646903 (OR = 1.72, 95% CI = 1.25-2.38), rs1048943 (OR = 1.40, 95% CI =... BeFree 22525558 Detail
0.126 Malignant neoplasm of lung In this Chinese cohort, with CYP1A1 valine allele frequency intermediate between... BeFree 11008920 Detail
0.107 Malignant neoplasm of urinary bladder CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (n... BeFree 23886208 Detail
0.104 Malignant neoplasm of breast We examined the potential association of breast cancer risk in Mexican women wit... BeFree 23000097 Detail
0.033 Malignant neoplasm of lung Furthermore, the combination of risk genotypes of CYP1B1 Leu432Val with CYP1A1 I... BeFree 17980933 Detail
0.028 Cancer of Head and Neck The estimated head and neck cancer risk for the combination of either CYP1A1 Ile... BeFree 18590468 Detail
0.005 cervix carcinoma CYP1A1 Ile462Val polymorphism and cervical cancer: evidence from a meta-analysis... BeFree 22948778 Detail
<0.001 Non-small cell lung carcinoma In this study, CYP1A1 (Ile462Val), CYP1B1(Asn453Ser), GST M1, GSTP1 exon 5 (Ile1... BeFree 20845989 Detail
0.008 Fibroid Tumor We concluded that the carriage of CYP1A1 Ile462Val AG and CYP1B1 Leu 432Val CC g... BeFree 20559649 Detail
0.093 Malignant neoplasm of urinary bladder CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (n... BeFree 23886208 Detail
0.124 Malignant neoplasm of lung CYP1A1 Ile462Val polymorphism and susceptibility to lung cancer: a meta-analysis... BeFree 22025136 Detail
0.044 Carcinoma of lung CYP1A1 I462V genetic polymorphism and lung cancer risk in a cohort of men in Sha... BeFree 11008920 Detail
0.006 Non-small cell lung carcinoma In this study, CYP1A1 (Ile462Val), CYP1B1(Asn453Ser), GST M1, GSTP1 exon 5 (Ile1... BeFree 20845989 Detail
0.101 Malignant neoplasm of breast We examined the potential association of breast cancer risk in Mexican women wit... BeFree 23000097 Detail
<0.001 Non-small cell lung carcinoma In this study, CYP1A1 (Ile462Val), CYP1B1(Asn453Ser), GST M1, GSTP1 exon 5 (Ile1... BeFree 20845989 Detail
0.003 T-Cell Lymphoma The CYP1A1 rs1048943 AG genotype and the combined AG/GG genotypes were associate... BeFree 19899130 Detail
0.005 Lip and oral cavity carcinoma Cytochrome P450 1A1 Ile462Val polymorphism and oral carcinoma risk: an updated m... BeFree 22847262 Detail
0.008 Malignant neoplasm of prostate To investigate this, we studied the association between prostate cancer and smok... BeFree 16614120 Detail
0.005 Carcinoma of lung Furthermore, the combination of risk genotypes of CYP1B1 Leu432Val with CYP1A1 I... BeFree 17980933 Detail
0.224 asthma To assess the effect of IL13 (-1112 C&gt;T and Arg110Gln), GSTP1 (Ile105Val), an... BeFree 22236719 Detail
0.102 Malignant neoplasm of breast We examined the potential association of breast cancer risk in Mexican women wit... BeFree 23000097 Detail
0.007 colorectal carcinoma Relationship between genetic polymorphism of CYP1A1 at codon 462 (Ile462Val) in ... BeFree 18409146 Detail
0.009 Carcinogenesis Our study therefore suggests that the CYP1A1 Ile(462)Val variant allele might pl... BeFree 12771031 Detail
0.003 ovarian carcinoma CYP1A1 Ile462Val is a risk factor for ovarian cancer development. BeFree 22277800 Detail
0.005 Adenocarcinoma of lung (disorder) Theses results suggest that the CYP1A1 Ile462Val polymorphism is associated with... BeFree 17980933 Detail
<0.001 Hereditary Nonpolyposis Colorectal Cancer Our results suggest that the I462V and Msp1 polymorphisms in CYP1A1 may be an ad... BeFree 18768509 Detail
0.072 colorectal cancer CYP1A1 Ile462Val polymorphism contributes to colorectal cancer risk: a meta-anal... BeFree 21246002 Detail
0.020 Carcinoma of lung CYP1A1 rs4646903 (OR = 1.72, 95% CI = 1.25-2.38), rs1048943 (OR = 1.40, 95% CI =... BeFree 22525558 Detail
0.011 Malignant neoplasm of urinary bladder CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (n... BeFree 23886208 Detail
0.003 ovarian carcinoma In this study, we investigated the impact of the CYP1A1 Ile462Val polymorphism u... BeFree 20377136 Detail
0.081 Malignant neoplasm of prostate To investigate this, we studied the association between prostate cancer and smok... BeFree 16614120 Detail
0.006 prostate carcinoma Quantitative synthesis of the association between the cytochrome P450 1A1 Ile462... BeFree 23381648 Detail
0.027 Carcinoma of bladder CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (n... BeFree 23886208 Detail
0.005 cervix carcinoma CYP1A1 Ile462Val polymorphism as a risk factor in cervical cancer development in... BeFree 24626963 Detail
0.491 asthma To assess the effect of IL13 (-1112 C&gt;T and Arg110Gln), GSTP1 (Ile105Val), an... BeFree 22236719 Detail
0.019 Lymphoma, Non-Hodgkin Our data provide evidence that the GSTP1 rs1695 and the CYP1A1 rs1048943 genotyp... BeFree 19899130 Detail
0.017 breast carcinoma We examined the potential association of breast cancer risk in Mexican women wit... BeFree 23000097 Detail
0.044 Carcinoma of lung CYP1A1 Ile462Val polymorphism contributes to lung cancer susceptibility among lu... BeFree 22952673 Detail
0.003 Malignant neoplasm of breast We here carried out a population based case-control study of the CYP MspI (CYP1A... BeFree 22292665 Detail
0.075 Malignant neoplasm of prostate Quantitative synthesis of the association between the cytochrome P450 1A1 Ile462... BeFree 23381648 Detail
0.092 Malignant neoplasm of lung CYP1A1 rs4646903 (OR = 1.72, 95% CI = 1.25-2.38), rs1048943 (OR = 1.40, 95% CI =... BeFree 22525558 Detail
0.044 Carcinoma of lung We examined an Ile462Val polymorphism (CYP1A1*2 allele) of cytochrome P450 IA1 i... BeFree 9610791 Detail
0.044 Carcinoma of lung The polymorphic frequency of 10 genetic susceptibility genes and their associati... BeFree 19963114 Detail
<0.001 Environmental Carcinogenesis To evaluate the roles of CYP1A1 polymorphisms [Ile 462Val and T 6235C (MspI)] an... BeFree 18463401 Detail
0.100 Malignant neoplasm of lung CYP1A1 rs4646903 (OR = 1.72, 95% CI = 1.25-2.38), rs1048943 (OR = 1.40, 95% CI =... BeFree 22525558 Detail
0.002 Uterine Fibroids The genetic polymorphism of rs3087869 (IVS1+2329C&gt;T) (OR 3.200, 95% CI 1.614-... BeFree 24777039 Detail
0.021 breast carcinoma We examined the potential association of breast cancer risk in Mexican women wit... BeFree 23000097 Detail
0.005 cervix carcinoma Association of CYP1A1 gene variants rs4646903 (T&gt;C) and rs1048943 (A&gt;G) wi... BeFree 24657182 Detail
0.001 Uterine Fibroids The genetic polymorphisms of IVS1+2329C&gt;T and Val158Met loci in COMT, Ile462V... BeFree 24320736 Detail
0.003 breast carcinoma We here carried out a population based case-control study of the CYP MspI (CYP1A... BeFree 22292665 Detail
<0.001 Brain Neoplasms The increased risk of brain tumors was evident for CYP1A1 rs2606345 (P = 0.0028;... BeFree 23661361 Detail
0.002 Uterine Fibroids The genetic polymorphisms of IVS1+2329C&gt;T and Val158Met loci in COMT, Ile462V... BeFree 24320736 Detail
0.009 endometrial carcinoma Lack of association between the CYP1A1 Ile462Val polymorphism and endometrial ca... BeFree 23098461 Detail
0.030 Malignant neoplasm of urinary bladder CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (n... BeFree 23886208 Detail
0.005 Fibroid Tumor We concluded that the carriage of CYP1A1 Ile462Val AG and CYP1B1 Leu 432Val CC g... BeFree 20559649 Detail
0.016 breast carcinoma We examined the potential association of breast cancer risk in Mexican women wit... BeFree 23000097 Detail
0.008 Fibroid Tumor These results suggest that the genotype of CYP1A1 Ile462Val was associated with ... BeFree 18763031 Detail
0.010 ovarian neoplasm The CYP1A1 Ile462Val polymorphism and platinum resistance of epithelial ovarian ... BeFree 20377136 Detail
0.096 Malignant neoplasm of breast We examined the potential association of breast cancer risk in Mexican women wit... BeFree 23000097 Detail
0.010 prostate carcinoma To investigate this, we studied the association between prostate cancer and smok... BeFree 16614120 Detail
0.013 Carcinoma of bladder CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (n... BeFree 23886208 Detail
0.004 Uterine Fibroids We concluded that the carriage of CYP1A1 Ile462Val AG and CYP1B1 Leu 432Val CC g... BeFree 20559649 Detail
0.003 adenocarcinoma CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but ... BeFree 16195240 Detail
0.024 breast carcinoma We examined the potential association of breast cancer risk in Mexican women wit... BeFree 23000097 Detail
0.044 Carcinoma of lung In Caucasians, those with the IIe/Val genotype at CYP1A1 Ile(462)Val locus were ... BeFree 17174438 Detail
0.001 acute leukemia Association between CYP1A1 Ile462Val variation and acute leukemia risk: meta-ana... BeFree 23056546 Detail
0.023 Lymphoma, Non-Hodgkin Our data provide evidence that the GSTP1 rs1695 and the CYP1A1 rs1048943 genotyp... BeFree 19899130 Detail
0.004 Malignant neoplasm of endometrium Lack of association between the CYP1A1 Ile462Val polymorphism and endometrial ca... BeFree 23098461 Detail
0.016 Cancer of Head and Neck The estimated head and neck cancer risk for the combination of either CYP1A1 Ile... BeFree 18590468 Detail
<0.001 Carcinoma of ampulla of Vater The CYP1A1 IVS1 + 606 (rs2606345) T allele was associated with gallbladder [odds... BeFree 19168589 Detail
<0.001 Environmental Carcinogenesis To evaluate the roles of CYP1A1 polymorphisms [Ile 462Val and T 6235C (MspI)] an... BeFree 18463401 Detail
0.003 Malignant tumor of cervix CYP1A1 Ile462Val polymorphism as a risk factor in cervical cancer development in... BeFree 24626963 Detail
0.002 Non-small cell lung carcinoma In this study, CYP1A1 (Ile462Val), CYP1B1(Asn453Ser), GST M1, GSTP1 exon 5 (Ile1... BeFree 20845989 Detail
0.003 Malignant tumor of cervix CYP1A1 Ile462Val polymorphism and cervical cancer: evidence from a meta-analysis... BeFree 22948778 Detail
0.004 Uterine Fibroids The genetic polymorphism of rs3087869 (IVS1+2329C&gt;T) (OR 3.200, 95% CI 1.614-... BeFree 24777039 Detail
0.124 Malignant neoplasm of lung CYP1A1 I462V genetic polymorphism and lung cancer risk in a cohort of men in Sha... BeFree 11008920 Detail
0.006 Non-small cell lung carcinoma These new data establish an association between the CYP1A1 Ile462Val polymorphis... BeFree 15986113 Detail
0.007 colorectal carcinoma CYP1A1 Ile462Val polymorphism and colorectal cancer risk in Polish patients. BeFree 24939416 Detail
0.019 breast carcinoma We examined the potential association of breast cancer risk in Mexican women wit... BeFree 23000097 Detail
0.003 Squamous cell carcinoma of lung CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but ... BeFree 16195240 Detail
0.006 prostate carcinoma To investigate this, we studied the association between prostate cancer and smok... BeFree 16614120 Detail
<0.001 Environmental Carcinogenesis To evaluate the roles of CYP1A1 polymorphisms [Ile 462Val and T 6235C (MspI)] an... BeFree 18463401 Detail
0.124 Malignant neoplasm of lung In Caucasians, those with the IIe/Val genotype at CYP1A1 Ile(462)Val locus were ... BeFree 17174438 Detail
0.003 Malignant tumor of cervix Association of CYP1A1 gene variants rs4646903 (T&gt;C) and rs1048943 (A&gt;G) wi... BeFree 24657182 Detail
0.026 prostate carcinoma To investigate this, we studied the association between prostate cancer and smok... BeFree 16614120 Detail
0.007 colorectal carcinoma CYP1A1 Ile462Val polymorphism contributes to colorectal cancer risk: a meta-anal... BeFree 21246002 Detail
0.072 colorectal cancer CYP1A1 Ile462Val polymorphism and colorectal cancer risk in Polish patients. BeFree 24939416 Detail
0.099 Malignant neoplasm of breast We examined the potential association of breast cancer risk in Mexican women wit... BeFree 23000097 Detail
0.006 Non-small cell lung carcinoma CYP1A1 Ile462Val polymorphism and the risk of non-small cell lung cancer in a Ch... BeFree 25343551 Detail
0.002 Carcinoma of bladder CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (n... BeFree 23886208 Detail
0.004 uterine corpus cancer Lack of association between the CYP1A1 Ile462Val polymorphism and endometrial ca... BeFree 23098461 Detail
0.124 Malignant neoplasm of lung The polymorphic frequency of 10 genetic susceptibility genes and their associati... BeFree 19963114 Detail
0.011 polycystic ovary syndrome Lack of an association between CYP1A1 gene Ile462Val polymorphism and polycystic... BeFree 19507064 Detail
0.017 Malignant neoplasm of ovary In this study, we investigated the impact of the CYP1A1 Ile462Val polymorphism u... BeFree 20377136 Detail
0.075 Malignant neoplasm of prostate To investigate this, we studied the association between prostate cancer and smok... BeFree 16614120 Detail
0.003 Malignant tumor of cervix (2) rs1048943 (CYP1A1 A4889G) showed the strongest association with cervical can... BeFree 25928231 Detail
0.044 Carcinoma of lung CYP1A1 Ile462Val polymorphism and susceptibility to lung cancer: a meta-analysis... BeFree 22025136 Detail
0.124 Malignant neoplasm of lung Theses results suggest that the CYP1A1 Ile462Val polymorphism is associated with... BeFree 17980933 Detail
<0.001 Oral Cavity Carcinoma Cytochrome P450 1A1 Ile462Val polymorphism and oral carcinoma risk: an updated m... BeFree 22847262 Detail
0.017 Malignant neoplasm of ovary CYP1A1 Ile462Val is a risk factor for ovarian cancer development. BeFree 22277800 Detail
0.022 breast carcinoma We examined the potential association of breast cancer risk in Mexican women wit... BeFree 23000097 Detail
0.087 Malignant neoplasm of prostate To investigate this, we studied the association between prostate cancer and smok... BeFree 16614120 Detail
0.003 Carcinoma of bladder CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (n... BeFree 23886208 Detail
0.001 Lymphoma, Large-Cell, Follicular Our data provide evidence that the GSTP1 rs1695 and the CYP1A1 rs1048943 genotyp... BeFree 19899130 Detail
0.076 squamous cell carcinoma CYP1A1 Ile462Val polymorphism contributes to lung cancer susceptibility among lu... BeFree 22952673 Detail
0.012 Carcinoma of lung CYP1A1 rs4646903 (OR = 1.72, 95% CI = 1.25-2.38), rs1048943 (OR = 1.40, 95% CI =... BeFree 22525558 Detail
0.005 Adenocarcinoma of lung (disorder) The odds ratio (OR) of lung cancer for the variant CYP1A1 Ile(462)Val polymorphi... BeFree 12771031 Detail
0.004 Uterine Fibroids The genetic polymorphisms of IVS1+2329C&gt;T and Val158Met loci in COMT, Ile462V... BeFree 24320736 Detail
0.124 Malignant neoplasm of lung CYP1A1 Ile462Val polymorphism contributes to lung cancer susceptibility among lu... BeFree 22952673 Detail
0.003 Squamous cell carcinoma of lung CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but ... BeFree 16195240 Detail
0.047 Carcinoma of lung In this Chinese cohort, with CYP1A1 valine allele frequency intermediate between... BeFree 11008920 Detail
0.001 prostate carcinoma To investigate this, we studied the association between prostate cancer and smok... BeFree 16614120 Detail
0.044 Carcinoma of lung Theses results suggest that the CYP1A1 Ile462Val polymorphism is associated with... BeFree 17980933 Detail
<0.001 male infertility Novel interactions were also observed between the MR of SEC and rs1042389 in CYP... BeFree 24488272 Detail
0.132 male infertility Novel interactions were also observed between the MR of SEC and rs1042389 in CYP... BeFree 24488272 Detail
0.002 gallbladder carcinoma These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and t... BeFree 17531965 Detail
Annotation

Annotations

DescrptionSourceLinks
These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and the Pro allele of TP5... DisGeNET Detail
The increased risk of breast cancer associated with E+P use was greater among women with at least on... DisGeNET Detail
The increased risk of breast cancer associated with E+P use was greater among women with at least on... DisGeNET Detail
The increased risk of breast cancer associated with E+P use was greater among women with at least on... DisGeNET Detail
The increased risk of breast cancer associated with E+P use was greater among women with at least on... DisGeNET Detail
All subjects were genotyped for 13 polymorphic variants in the genes of xenobiotics detoxification C... DisGeNET Detail
All subjects were genotyped for 13 polymorphic variants in the genes of xenobiotics detoxification C... DisGeNET Detail
All subjects were genotyped for 13 polymorphic variants in the genes of xenobiotics detoxification C... DisGeNET Detail
All subjects were genotyped for 13 polymorphic variants in the genes of xenobiotics detoxification C... DisGeNET Detail
All subjects were genotyped for 13 polymorphic variants in the genes of xenobiotics detoxification C... DisGeNET Detail
However, further studies are still needed to accurately determine whether the CYP1A1 rs1048943 (A&gt... DisGeNET Detail
We examined an Ile462Val polymorphism (CYP1A1*2 allele) of cytochrome P450 IA1 in a hospital-based c... DisGeNET Detail
Furthermore, the combination of risk genotypes of CYP1B1 Leu432Val with CYP1A1 Ile462Val was associa... DisGeNET Detail
CYP1A1 rs4646903 (OR = 1.72, 95% CI = 1.25-2.38), rs1048943 (OR = 1.40, 95% CI = 1.02-1.92), the GST... DisGeNET Detail
Relationship between genetic polymorphism of CYP1A1 at codon 462 (Ile462Val) in colorectal cancer. DisGeNET Detail
Our data provide evidence that the GSTP1 rs1695 and the CYP1A1 rs1048943 genotypes affect the risk o... DisGeNET Detail
In this study, CYP1A1 (Ile462Val), CYP1B1(Asn453Ser), GST M1, GSTP1 exon 5 (Ile105Val) and exon 6(Al... DisGeNET Detail
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... DisGeNET Detail
(2) rs1048943 (CYP1A1 A4889G) showed the strongest association with cervical cancer in the allele ef... DisGeNET Detail
CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell ca... DisGeNET Detail
The genetic polymorphism of rs3087869 (IVS1+2329C&gt;T) (OR 3.200, 95% CI 1.614-6.345) and rs4680 (V... DisGeNET Detail
CYP1A1 rs4646903 (OR = 1.72, 95% CI = 1.25-2.38), rs1048943 (OR = 1.40, 95% CI = 1.02-1.92), the GST... DisGeNET Detail
In this Chinese cohort, with CYP1A1 valine allele frequency intermediate between Japanese and Caucas... DisGeNET Detail
CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (null) polymorphisms a... DisGeNET Detail
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... DisGeNET Detail
Furthermore, the combination of risk genotypes of CYP1B1 Leu432Val with CYP1A1 Ile462Val was associa... DisGeNET Detail
The estimated head and neck cancer risk for the combination of either CYP1A1 Ile462Val or CYP1A1 Val... DisGeNET Detail
CYP1A1 Ile462Val polymorphism and cervical cancer: evidence from a meta-analysis. DisGeNET Detail
In this study, CYP1A1 (Ile462Val), CYP1B1(Asn453Ser), GST M1, GSTP1 exon 5 (Ile105Val) and exon 6(Al... DisGeNET Detail
We concluded that the carriage of CYP1A1 Ile462Val AG and CYP1B1 Leu 432Val CC genotypes predict the... DisGeNET Detail
CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (null) polymorphisms a... DisGeNET Detail
CYP1A1 Ile462Val polymorphism and susceptibility to lung cancer: a meta-analysis based on 32 studies... DisGeNET Detail
CYP1A1 I462V genetic polymorphism and lung cancer risk in a cohort of men in Shanghai, China. DisGeNET Detail
In this study, CYP1A1 (Ile462Val), CYP1B1(Asn453Ser), GST M1, GSTP1 exon 5 (Ile105Val) and exon 6(Al... DisGeNET Detail
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... DisGeNET Detail
In this study, CYP1A1 (Ile462Val), CYP1B1(Asn453Ser), GST M1, GSTP1 exon 5 (Ile105Val) and exon 6(Al... DisGeNET Detail
The CYP1A1 rs1048943 AG genotype and the combined AG/GG genotypes were associated with increased ris... DisGeNET Detail
Cytochrome P450 1A1 Ile462Val polymorphism and oral carcinoma risk: an updated meta-analysis includi... DisGeNET Detail
To investigate this, we studied the association between prostate cancer and smoking, as well as the ... DisGeNET Detail
Furthermore, the combination of risk genotypes of CYP1B1 Leu432Val with CYP1A1 Ile462Val was associa... DisGeNET Detail
To assess the effect of IL13 (-1112 C&gt;T and Arg110Gln), GSTP1 (Ile105Val), and CYP1A1 (Ile462Val)... DisGeNET Detail
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... DisGeNET Detail
Relationship between genetic polymorphism of CYP1A1 at codon 462 (Ile462Val) in colorectal cancer. DisGeNET Detail
Our study therefore suggests that the CYP1A1 Ile(462)Val variant allele might play a role in lung ca... DisGeNET Detail
CYP1A1 Ile462Val is a risk factor for ovarian cancer development. DisGeNET Detail
Theses results suggest that the CYP1A1 Ile462Val polymorphism is associated with a reduced risk of l... DisGeNET Detail
Our results suggest that the I462V and Msp1 polymorphisms in CYP1A1 may be an additional susceptibil... DisGeNET Detail
CYP1A1 Ile462Val polymorphism contributes to colorectal cancer risk: a meta-analysis. DisGeNET Detail
CYP1A1 rs4646903 (OR = 1.72, 95% CI = 1.25-2.38), rs1048943 (OR = 1.40, 95% CI = 1.02-1.92), the GST... DisGeNET Detail
CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (null) polymorphisms a... DisGeNET Detail
In this study, we investigated the impact of the CYP1A1 Ile462Val polymorphism upon tumor risk and d... DisGeNET Detail
To investigate this, we studied the association between prostate cancer and smoking, as well as the ... DisGeNET Detail
Quantitative synthesis of the association between the cytochrome P450 1A1 Ile462Val polymorphism and... DisGeNET Detail
CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (null) polymorphisms a... DisGeNET Detail
CYP1A1 Ile462Val polymorphism as a risk factor in cervical cancer development in the Polish populati... DisGeNET Detail
To assess the effect of IL13 (-1112 C&gt;T and Arg110Gln), GSTP1 (Ile105Val), and CYP1A1 (Ile462Val)... DisGeNET Detail
Our data provide evidence that the GSTP1 rs1695 and the CYP1A1 rs1048943 genotypes affect the risk o... DisGeNET Detail
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... DisGeNET Detail
CYP1A1 Ile462Val polymorphism contributes to lung cancer susceptibility among lung squamous carcinom... DisGeNET Detail
We here carried out a population based case-control study of the CYP MspI (CYP1A1*1/M1) and Ile462Va... DisGeNET Detail
Quantitative synthesis of the association between the cytochrome P450 1A1 Ile462Val polymorphism and... DisGeNET Detail
CYP1A1 rs4646903 (OR = 1.72, 95% CI = 1.25-2.38), rs1048943 (OR = 1.40, 95% CI = 1.02-1.92), the GST... DisGeNET Detail
We examined an Ile462Val polymorphism (CYP1A1*2 allele) of cytochrome P450 IA1 in a hospital-based c... DisGeNET Detail
The polymorphic frequency of 10 genetic susceptibility genes and their association with lung cancer ... DisGeNET Detail
To evaluate the roles of CYP1A1 polymorphisms [Ile 462Val and T 6235C (MspI)] and deletion of GSTM1 ... DisGeNET Detail
CYP1A1 rs4646903 (OR = 1.72, 95% CI = 1.25-2.38), rs1048943 (OR = 1.40, 95% CI = 1.02-1.92), the GST... DisGeNET Detail
The genetic polymorphism of rs3087869 (IVS1+2329C&gt;T) (OR 3.200, 95% CI 1.614-6.345) and rs4680 (V... DisGeNET Detail
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... DisGeNET Detail
Association of CYP1A1 gene variants rs4646903 (T&gt;C) and rs1048943 (A&gt;G) with cervical cancer i... DisGeNET Detail
The genetic polymorphisms of IVS1+2329C&gt;T and Val158Met loci in COMT, Ile462Val and Gly45Asp loci... DisGeNET Detail
We here carried out a population based case-control study of the CYP MspI (CYP1A1*1/M1) and Ile462Va... DisGeNET Detail
The increased risk of brain tumors was evident for CYP1A1 rs2606345 (P = 0.0028; OR = 2.06; 95 % CI,... DisGeNET Detail
The genetic polymorphisms of IVS1+2329C&gt;T and Val158Met loci in COMT, Ile462Val and Gly45Asp loci... DisGeNET Detail
Lack of association between the CYP1A1 Ile462Val polymorphism and endometrial cancer risk: a meta-an... DisGeNET Detail
CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (null) polymorphisms a... DisGeNET Detail
We concluded that the carriage of CYP1A1 Ile462Val AG and CYP1B1 Leu 432Val CC genotypes predict the... DisGeNET Detail
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... DisGeNET Detail
These results suggest that the genotype of CYP1A1 Ile462Val was associated with the increased risk o... DisGeNET Detail
The CYP1A1 Ile462Val polymorphism and platinum resistance of epithelial ovarian neoplasms. DisGeNET Detail
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... DisGeNET Detail
To investigate this, we studied the association between prostate cancer and smoking, as well as the ... DisGeNET Detail
CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (null) polymorphisms a... DisGeNET Detail
We concluded that the carriage of CYP1A1 Ile462Val AG and CYP1B1 Leu 432Val CC genotypes predict the... DisGeNET Detail
CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell ca... DisGeNET Detail
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... DisGeNET Detail
In Caucasians, those with the IIe/Val genotype at CYP1A1 Ile(462)Val locus were at decreased risk of... DisGeNET Detail
Association between CYP1A1 Ile462Val variation and acute leukemia risk: meta-analyses including 2164... DisGeNET Detail
Our data provide evidence that the GSTP1 rs1695 and the CYP1A1 rs1048943 genotypes affect the risk o... DisGeNET Detail
Lack of association between the CYP1A1 Ile462Val polymorphism and endometrial cancer risk: a meta-an... DisGeNET Detail
The estimated head and neck cancer risk for the combination of either CYP1A1 Ile462Val or CYP1A1 Val... DisGeNET Detail
The CYP1A1 IVS1 + 606 (rs2606345) T allele was associated with gallbladder [odds ratio (OR) = 2.0, 9... DisGeNET Detail
To evaluate the roles of CYP1A1 polymorphisms [Ile 462Val and T 6235C (MspI)] and deletion of GSTM1 ... DisGeNET Detail
CYP1A1 Ile462Val polymorphism as a risk factor in cervical cancer development in the Polish populati... DisGeNET Detail
In this study, CYP1A1 (Ile462Val), CYP1B1(Asn453Ser), GST M1, GSTP1 exon 5 (Ile105Val) and exon 6(Al... DisGeNET Detail
CYP1A1 Ile462Val polymorphism and cervical cancer: evidence from a meta-analysis. DisGeNET Detail
The genetic polymorphism of rs3087869 (IVS1+2329C&gt;T) (OR 3.200, 95% CI 1.614-6.345) and rs4680 (V... DisGeNET Detail
CYP1A1 I462V genetic polymorphism and lung cancer risk in a cohort of men in Shanghai, China. DisGeNET Detail
These new data establish an association between the CYP1A1 Ile462Val polymorphism and the risk of de... DisGeNET Detail
CYP1A1 Ile462Val polymorphism and colorectal cancer risk in Polish patients. DisGeNET Detail
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... DisGeNET Detail
CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell ca... DisGeNET Detail
To investigate this, we studied the association between prostate cancer and smoking, as well as the ... DisGeNET Detail
To evaluate the roles of CYP1A1 polymorphisms [Ile 462Val and T 6235C (MspI)] and deletion of GSTM1 ... DisGeNET Detail
In Caucasians, those with the IIe/Val genotype at CYP1A1 Ile(462)Val locus were at decreased risk of... DisGeNET Detail
Association of CYP1A1 gene variants rs4646903 (T&gt;C) and rs1048943 (A&gt;G) with cervical cancer i... DisGeNET Detail
To investigate this, we studied the association between prostate cancer and smoking, as well as the ... DisGeNET Detail
CYP1A1 Ile462Val polymorphism contributes to colorectal cancer risk: a meta-analysis. DisGeNET Detail
CYP1A1 Ile462Val polymorphism and colorectal cancer risk in Polish patients. DisGeNET Detail
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... DisGeNET Detail
CYP1A1 Ile462Val polymorphism and the risk of non-small cell lung cancer in a Chinese population. DisGeNET Detail
CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (null) polymorphisms a... DisGeNET Detail
Lack of association between the CYP1A1 Ile462Val polymorphism and endometrial cancer risk: a meta-an... DisGeNET Detail
The polymorphic frequency of 10 genetic susceptibility genes and their association with lung cancer ... DisGeNET Detail
Lack of an association between CYP1A1 gene Ile462Val polymorphism and polycystic ovary syndrome in C... DisGeNET Detail
In this study, we investigated the impact of the CYP1A1 Ile462Val polymorphism upon tumor risk and d... DisGeNET Detail
To investigate this, we studied the association between prostate cancer and smoking, as well as the ... DisGeNET Detail
(2) rs1048943 (CYP1A1 A4889G) showed the strongest association with cervical cancer in the allele ef... DisGeNET Detail
CYP1A1 Ile462Val polymorphism and susceptibility to lung cancer: a meta-analysis based on 32 studies... DisGeNET Detail
Theses results suggest that the CYP1A1 Ile462Val polymorphism is associated with a reduced risk of l... DisGeNET Detail
Cytochrome P450 1A1 Ile462Val polymorphism and oral carcinoma risk: an updated meta-analysis includi... DisGeNET Detail
CYP1A1 Ile462Val is a risk factor for ovarian cancer development. DisGeNET Detail
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... DisGeNET Detail
To investigate this, we studied the association between prostate cancer and smoking, as well as the ... DisGeNET Detail
CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (null) polymorphisms a... DisGeNET Detail
Our data provide evidence that the GSTP1 rs1695 and the CYP1A1 rs1048943 genotypes affect the risk o... DisGeNET Detail
CYP1A1 Ile462Val polymorphism contributes to lung cancer susceptibility among lung squamous carcinom... DisGeNET Detail
CYP1A1 rs4646903 (OR = 1.72, 95% CI = 1.25-2.38), rs1048943 (OR = 1.40, 95% CI = 1.02-1.92), the GST... DisGeNET Detail
The odds ratio (OR) of lung cancer for the variant CYP1A1 Ile(462)Val polymorphism (Ile/Val, Val/Val... DisGeNET Detail
The genetic polymorphisms of IVS1+2329C&gt;T and Val158Met loci in COMT, Ile462Val and Gly45Asp loci... DisGeNET Detail
CYP1A1 Ile462Val polymorphism contributes to lung cancer susceptibility among lung squamous carcinom... DisGeNET Detail
CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell ca... DisGeNET Detail
In this Chinese cohort, with CYP1A1 valine allele frequency intermediate between Japanese and Caucas... DisGeNET Detail
To investigate this, we studied the association between prostate cancer and smoking, as well as the ... DisGeNET Detail
Theses results suggest that the CYP1A1 Ile462Val polymorphism is associated with a reduced risk of l... DisGeNET Detail
Novel interactions were also observed between the MR of SEC and rs1042389 in CYP2B6, rs1048943 in CY... DisGeNET Detail
Novel interactions were also observed between the MR of SEC and rs1042389 in CYP2B6, rs1048943 in CY... DisGeNET Detail
These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and the Pro allele of TP5... DisGeNET Detail

Overlapped Transcript Coordinates

Gene Transcript ID Exon Number Chromosome Start Stop Type Amino Mutation Transcript Position Links

Overlapped Transcript

Gene Transcript ID Chromosome Start Stop Links
Gene
-
dbSNP
rs1048943 dbSNP
Genome
hg19
Position
chr15:75,012,985-75,012,985
Variant Type
snv
Reference Allele
T
Alternative Allele
G
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