chr15:75012985:T>A Detail (hg19) (CYP1A1)
Information
Genome
Assembly | Position |
---|---|
hg19 | chr15:75,012,985-75,012,985 |
hg38 | chr15:74,720,644-74,720,644 View the variant detail on this assembly version. |
HGVS
Type | Transcript | Protein |
---|---|---|
RefSeq | NM_001319216.1:c.1297A>T | NP_001306145.1:p.Ile433Phe |
NM_000499.4:c.1384A>T | NP_000490.1:p.Ile462Phe | |
NM_001319217.1:c.1384A>T | NP_001306146.1:p.Ile462Phe |
Summary
MGeND
Clinical significance | |
Variant entry | |
GWAS entry | |
Disease area statistics | Show details |
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
Score | Disease name | Description | Source | Pubmed | Links |
---|---|---|---|---|---|
0.002 | Malignant neoplasm of gallbladder | These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and t... | BeFree | 17531965 | Detail |
0.080 | breast carcinoma | The increased risk of breast cancer associated with E+P use was greater among wo... | BeFree | 18628428 | Detail |
0.132 | Malignant neoplasm of breast | The increased risk of breast cancer associated with E+P use was greater among wo... | BeFree | 18628428 | Detail |
0.104 | Malignant neoplasm of breast | The increased risk of breast cancer associated with E+P use was greater among wo... | BeFree | 18628428 | Detail |
0.024 | breast carcinoma | The increased risk of breast cancer associated with E+P use was greater among wo... | BeFree | 18628428 | Detail |
0.001 | vascular disease occlusive | All subjects were genotyped for 13 polymorphic variants in the genes of xenobiot... | BeFree | 23107763 | Detail |
0.337 | hyperhomocysteinemia | All subjects were genotyped for 13 polymorphic variants in the genes of xenobiot... | BeFree | 23107763 | Detail |
<0.001 | hyperhomocysteinemia | All subjects were genotyped for 13 polymorphic variants in the genes of xenobiot... | BeFree | 23107763 | Detail |
0.146 | Homocysteinemia | All subjects were genotyped for 13 polymorphic variants in the genes of xenobiot... | BeFree | 23107763 | Detail |
<0.001 | Homocysteinemia | All subjects were genotyped for 13 polymorphic variants in the genes of xenobiot... | BeFree | 23107763 | Detail |
0.001 | Ovarian Diseases | However, further studies are still needed to accurately determine whether the CY... | BeFree | 23848208 | Detail |
0.124 | Malignant neoplasm of lung | We examined an Ile462Val polymorphism (CYP1A1*2 allele) of cytochrome P450 IA1 i... | BeFree | 9610791 | Detail |
<0.001 | Adenocarcinoma of lung (disorder) | Furthermore, the combination of risk genotypes of CYP1B1 Leu432Val with CYP1A1 I... | BeFree | 17980933 | Detail |
0.044 | Malignant neoplasm of lung | CYP1A1 rs4646903 (OR = 1.72, 95% CI = 1.25-2.38), rs1048943 (OR = 1.40, 95% CI =... | BeFree | 22525558 | Detail |
0.072 | colorectal cancer | Relationship between genetic polymorphism of CYP1A1 at codon 462 (Ile462Val) in ... | BeFree | 18409146 | Detail |
<0.001 | Lymphoma, Large-Cell, Follicular | Our data provide evidence that the GSTP1 rs1695 and the CYP1A1 rs1048943 genotyp... | BeFree | 19899130 | Detail |
0.002 | Non-small cell lung carcinoma | In this study, CYP1A1 (Ile462Val), CYP1B1(Asn453Ser), GST M1, GSTP1 exon 5 (Ile1... | BeFree | 20845989 | Detail |
0.097 | Malignant neoplasm of breast | We examined the potential association of breast cancer risk in Mexican women wit... | BeFree | 23000097 | Detail |
0.005 | cervix carcinoma | (2) rs1048943 (CYP1A1 A4889G) showed the strongest association with cervical can... | BeFree | 25928231 | Detail |
0.014 | adenocarcinoma | CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but ... | BeFree | 16195240 | Detail |
0.001 | Uterine Fibroids | The genetic polymorphism of rs3087869 (IVS1+2329C>T) (OR 3.200, 95% CI 1.614-... | BeFree | 24777039 | Detail |
0.007 | Carcinoma of lung | CYP1A1 rs4646903 (OR = 1.72, 95% CI = 1.25-2.38), rs1048943 (OR = 1.40, 95% CI =... | BeFree | 22525558 | Detail |
0.126 | Malignant neoplasm of lung | In this Chinese cohort, with CYP1A1 valine allele frequency intermediate between... | BeFree | 11008920 | Detail |
0.107 | Malignant neoplasm of urinary bladder | CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (n... | BeFree | 23886208 | Detail |
0.104 | Malignant neoplasm of breast | We examined the potential association of breast cancer risk in Mexican women wit... | BeFree | 23000097 | Detail |
0.033 | Malignant neoplasm of lung | Furthermore, the combination of risk genotypes of CYP1B1 Leu432Val with CYP1A1 I... | BeFree | 17980933 | Detail |
0.028 | Cancer of Head and Neck | The estimated head and neck cancer risk for the combination of either CYP1A1 Ile... | BeFree | 18590468 | Detail |
0.005 | cervix carcinoma | CYP1A1 Ile462Val polymorphism and cervical cancer: evidence from a meta-analysis... | BeFree | 22948778 | Detail |
<0.001 | Non-small cell lung carcinoma | In this study, CYP1A1 (Ile462Val), CYP1B1(Asn453Ser), GST M1, GSTP1 exon 5 (Ile1... | BeFree | 20845989 | Detail |
0.008 | Fibroid Tumor | We concluded that the carriage of CYP1A1 Ile462Val AG and CYP1B1 Leu 432Val CC g... | BeFree | 20559649 | Detail |
0.093 | Malignant neoplasm of urinary bladder | CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (n... | BeFree | 23886208 | Detail |
0.124 | Malignant neoplasm of lung | CYP1A1 Ile462Val polymorphism and susceptibility to lung cancer: a meta-analysis... | BeFree | 22025136 | Detail |
0.044 | Carcinoma of lung | CYP1A1 I462V genetic polymorphism and lung cancer risk in a cohort of men in Sha... | BeFree | 11008920 | Detail |
0.006 | Non-small cell lung carcinoma | In this study, CYP1A1 (Ile462Val), CYP1B1(Asn453Ser), GST M1, GSTP1 exon 5 (Ile1... | BeFree | 20845989 | Detail |
0.101 | Malignant neoplasm of breast | We examined the potential association of breast cancer risk in Mexican women wit... | BeFree | 23000097 | Detail |
<0.001 | Non-small cell lung carcinoma | In this study, CYP1A1 (Ile462Val), CYP1B1(Asn453Ser), GST M1, GSTP1 exon 5 (Ile1... | BeFree | 20845989 | Detail |
0.003 | T-Cell Lymphoma | The CYP1A1 rs1048943 AG genotype and the combined AG/GG genotypes were associate... | BeFree | 19899130 | Detail |
0.005 | Lip and oral cavity carcinoma | Cytochrome P450 1A1 Ile462Val polymorphism and oral carcinoma risk: an updated m... | BeFree | 22847262 | Detail |
0.008 | Malignant neoplasm of prostate | To investigate this, we studied the association between prostate cancer and smok... | BeFree | 16614120 | Detail |
0.005 | Carcinoma of lung | Furthermore, the combination of risk genotypes of CYP1B1 Leu432Val with CYP1A1 I... | BeFree | 17980933 | Detail |
0.224 | asthma | To assess the effect of IL13 (-1112 C>T and Arg110Gln), GSTP1 (Ile105Val), an... | BeFree | 22236719 | Detail |
0.102 | Malignant neoplasm of breast | We examined the potential association of breast cancer risk in Mexican women wit... | BeFree | 23000097 | Detail |
0.007 | colorectal carcinoma | Relationship between genetic polymorphism of CYP1A1 at codon 462 (Ile462Val) in ... | BeFree | 18409146 | Detail |
0.009 | Carcinogenesis | Our study therefore suggests that the CYP1A1 Ile(462)Val variant allele might pl... | BeFree | 12771031 | Detail |
0.003 | ovarian carcinoma | CYP1A1 Ile462Val is a risk factor for ovarian cancer development. | BeFree | 22277800 | Detail |
0.005 | Adenocarcinoma of lung (disorder) | Theses results suggest that the CYP1A1 Ile462Val polymorphism is associated with... | BeFree | 17980933 | Detail |
<0.001 | Hereditary Nonpolyposis Colorectal Cancer | Our results suggest that the I462V and Msp1 polymorphisms in CYP1A1 may be an ad... | BeFree | 18768509 | Detail |
0.072 | colorectal cancer | CYP1A1 Ile462Val polymorphism contributes to colorectal cancer risk: a meta-anal... | BeFree | 21246002 | Detail |
0.020 | Carcinoma of lung | CYP1A1 rs4646903 (OR = 1.72, 95% CI = 1.25-2.38), rs1048943 (OR = 1.40, 95% CI =... | BeFree | 22525558 | Detail |
0.011 | Malignant neoplasm of urinary bladder | CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (n... | BeFree | 23886208 | Detail |
0.003 | ovarian carcinoma | In this study, we investigated the impact of the CYP1A1 Ile462Val polymorphism u... | BeFree | 20377136 | Detail |
0.081 | Malignant neoplasm of prostate | To investigate this, we studied the association between prostate cancer and smok... | BeFree | 16614120 | Detail |
0.006 | prostate carcinoma | Quantitative synthesis of the association between the cytochrome P450 1A1 Ile462... | BeFree | 23381648 | Detail |
0.027 | Carcinoma of bladder | CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (n... | BeFree | 23886208 | Detail |
0.005 | cervix carcinoma | CYP1A1 Ile462Val polymorphism as a risk factor in cervical cancer development in... | BeFree | 24626963 | Detail |
0.491 | asthma | To assess the effect of IL13 (-1112 C>T and Arg110Gln), GSTP1 (Ile105Val), an... | BeFree | 22236719 | Detail |
0.019 | Lymphoma, Non-Hodgkin | Our data provide evidence that the GSTP1 rs1695 and the CYP1A1 rs1048943 genotyp... | BeFree | 19899130 | Detail |
0.017 | breast carcinoma | We examined the potential association of breast cancer risk in Mexican women wit... | BeFree | 23000097 | Detail |
0.044 | Carcinoma of lung | CYP1A1 Ile462Val polymorphism contributes to lung cancer susceptibility among lu... | BeFree | 22952673 | Detail |
0.003 | Malignant neoplasm of breast | We here carried out a population based case-control study of the CYP MspI (CYP1A... | BeFree | 22292665 | Detail |
0.075 | Malignant neoplasm of prostate | Quantitative synthesis of the association between the cytochrome P450 1A1 Ile462... | BeFree | 23381648 | Detail |
0.092 | Malignant neoplasm of lung | CYP1A1 rs4646903 (OR = 1.72, 95% CI = 1.25-2.38), rs1048943 (OR = 1.40, 95% CI =... | BeFree | 22525558 | Detail |
0.044 | Carcinoma of lung | We examined an Ile462Val polymorphism (CYP1A1*2 allele) of cytochrome P450 IA1 i... | BeFree | 9610791 | Detail |
0.044 | Carcinoma of lung | The polymorphic frequency of 10 genetic susceptibility genes and their associati... | BeFree | 19963114 | Detail |
<0.001 | Environmental Carcinogenesis | To evaluate the roles of CYP1A1 polymorphisms [Ile 462Val and T 6235C (MspI)] an... | BeFree | 18463401 | Detail |
0.100 | Malignant neoplasm of lung | CYP1A1 rs4646903 (OR = 1.72, 95% CI = 1.25-2.38), rs1048943 (OR = 1.40, 95% CI =... | BeFree | 22525558 | Detail |
0.002 | Uterine Fibroids | The genetic polymorphism of rs3087869 (IVS1+2329C>T) (OR 3.200, 95% CI 1.614-... | BeFree | 24777039 | Detail |
0.021 | breast carcinoma | We examined the potential association of breast cancer risk in Mexican women wit... | BeFree | 23000097 | Detail |
0.005 | cervix carcinoma | Association of CYP1A1 gene variants rs4646903 (T>C) and rs1048943 (A>G) wi... | BeFree | 24657182 | Detail |
0.001 | Uterine Fibroids | The genetic polymorphisms of IVS1+2329C>T and Val158Met loci in COMT, Ile462V... | BeFree | 24320736 | Detail |
0.003 | breast carcinoma | We here carried out a population based case-control study of the CYP MspI (CYP1A... | BeFree | 22292665 | Detail |
<0.001 | Brain Neoplasms | The increased risk of brain tumors was evident for CYP1A1 rs2606345 (P = 0.0028;... | BeFree | 23661361 | Detail |
0.002 | Uterine Fibroids | The genetic polymorphisms of IVS1+2329C>T and Val158Met loci in COMT, Ile462V... | BeFree | 24320736 | Detail |
0.009 | endometrial carcinoma | Lack of association between the CYP1A1 Ile462Val polymorphism and endometrial ca... | BeFree | 23098461 | Detail |
0.030 | Malignant neoplasm of urinary bladder | CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (n... | BeFree | 23886208 | Detail |
0.005 | Fibroid Tumor | We concluded that the carriage of CYP1A1 Ile462Val AG and CYP1B1 Leu 432Val CC g... | BeFree | 20559649 | Detail |
0.016 | breast carcinoma | We examined the potential association of breast cancer risk in Mexican women wit... | BeFree | 23000097 | Detail |
0.008 | Fibroid Tumor | These results suggest that the genotype of CYP1A1 Ile462Val was associated with ... | BeFree | 18763031 | Detail |
0.010 | ovarian neoplasm | The CYP1A1 Ile462Val polymorphism and platinum resistance of epithelial ovarian ... | BeFree | 20377136 | Detail |
0.096 | Malignant neoplasm of breast | We examined the potential association of breast cancer risk in Mexican women wit... | BeFree | 23000097 | Detail |
0.010 | prostate carcinoma | To investigate this, we studied the association between prostate cancer and smok... | BeFree | 16614120 | Detail |
0.013 | Carcinoma of bladder | CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (n... | BeFree | 23886208 | Detail |
0.004 | Uterine Fibroids | We concluded that the carriage of CYP1A1 Ile462Val AG and CYP1B1 Leu 432Val CC g... | BeFree | 20559649 | Detail |
0.003 | adenocarcinoma | CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but ... | BeFree | 16195240 | Detail |
0.024 | breast carcinoma | We examined the potential association of breast cancer risk in Mexican women wit... | BeFree | 23000097 | Detail |
0.044 | Carcinoma of lung | In Caucasians, those with the IIe/Val genotype at CYP1A1 Ile(462)Val locus were ... | BeFree | 17174438 | Detail |
0.001 | acute leukemia | Association between CYP1A1 Ile462Val variation and acute leukemia risk: meta-ana... | BeFree | 23056546 | Detail |
0.023 | Lymphoma, Non-Hodgkin | Our data provide evidence that the GSTP1 rs1695 and the CYP1A1 rs1048943 genotyp... | BeFree | 19899130 | Detail |
0.004 | Malignant neoplasm of endometrium | Lack of association between the CYP1A1 Ile462Val polymorphism and endometrial ca... | BeFree | 23098461 | Detail |
0.016 | Cancer of Head and Neck | The estimated head and neck cancer risk for the combination of either CYP1A1 Ile... | BeFree | 18590468 | Detail |
<0.001 | Carcinoma of ampulla of Vater | The CYP1A1 IVS1 + 606 (rs2606345) T allele was associated with gallbladder [odds... | BeFree | 19168589 | Detail |
<0.001 | Environmental Carcinogenesis | To evaluate the roles of CYP1A1 polymorphisms [Ile 462Val and T 6235C (MspI)] an... | BeFree | 18463401 | Detail |
0.003 | Malignant tumor of cervix | CYP1A1 Ile462Val polymorphism as a risk factor in cervical cancer development in... | BeFree | 24626963 | Detail |
0.002 | Non-small cell lung carcinoma | In this study, CYP1A1 (Ile462Val), CYP1B1(Asn453Ser), GST M1, GSTP1 exon 5 (Ile1... | BeFree | 20845989 | Detail |
0.003 | Malignant tumor of cervix | CYP1A1 Ile462Val polymorphism and cervical cancer: evidence from a meta-analysis... | BeFree | 22948778 | Detail |
0.004 | Uterine Fibroids | The genetic polymorphism of rs3087869 (IVS1+2329C>T) (OR 3.200, 95% CI 1.614-... | BeFree | 24777039 | Detail |
0.124 | Malignant neoplasm of lung | CYP1A1 I462V genetic polymorphism and lung cancer risk in a cohort of men in Sha... | BeFree | 11008920 | Detail |
0.006 | Non-small cell lung carcinoma | These new data establish an association between the CYP1A1 Ile462Val polymorphis... | BeFree | 15986113 | Detail |
0.007 | colorectal carcinoma | CYP1A1 Ile462Val polymorphism and colorectal cancer risk in Polish patients. | BeFree | 24939416 | Detail |
0.019 | breast carcinoma | We examined the potential association of breast cancer risk in Mexican women wit... | BeFree | 23000097 | Detail |
0.003 | Squamous cell carcinoma of lung | CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but ... | BeFree | 16195240 | Detail |
0.006 | prostate carcinoma | To investigate this, we studied the association between prostate cancer and smok... | BeFree | 16614120 | Detail |
<0.001 | Environmental Carcinogenesis | To evaluate the roles of CYP1A1 polymorphisms [Ile 462Val and T 6235C (MspI)] an... | BeFree | 18463401 | Detail |
0.124 | Malignant neoplasm of lung | In Caucasians, those with the IIe/Val genotype at CYP1A1 Ile(462)Val locus were ... | BeFree | 17174438 | Detail |
0.003 | Malignant tumor of cervix | Association of CYP1A1 gene variants rs4646903 (T>C) and rs1048943 (A>G) wi... | BeFree | 24657182 | Detail |
0.026 | prostate carcinoma | To investigate this, we studied the association between prostate cancer and smok... | BeFree | 16614120 | Detail |
0.007 | colorectal carcinoma | CYP1A1 Ile462Val polymorphism contributes to colorectal cancer risk: a meta-anal... | BeFree | 21246002 | Detail |
0.072 | colorectal cancer | CYP1A1 Ile462Val polymorphism and colorectal cancer risk in Polish patients. | BeFree | 24939416 | Detail |
0.099 | Malignant neoplasm of breast | We examined the potential association of breast cancer risk in Mexican women wit... | BeFree | 23000097 | Detail |
0.006 | Non-small cell lung carcinoma | CYP1A1 Ile462Val polymorphism and the risk of non-small cell lung cancer in a Ch... | BeFree | 25343551 | Detail |
0.002 | Carcinoma of bladder | CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (n... | BeFree | 23886208 | Detail |
0.004 | uterine corpus cancer | Lack of association between the CYP1A1 Ile462Val polymorphism and endometrial ca... | BeFree | 23098461 | Detail |
0.124 | Malignant neoplasm of lung | The polymorphic frequency of 10 genetic susceptibility genes and their associati... | BeFree | 19963114 | Detail |
0.011 | polycystic ovary syndrome | Lack of an association between CYP1A1 gene Ile462Val polymorphism and polycystic... | BeFree | 19507064 | Detail |
0.017 | Malignant neoplasm of ovary | In this study, we investigated the impact of the CYP1A1 Ile462Val polymorphism u... | BeFree | 20377136 | Detail |
0.075 | Malignant neoplasm of prostate | To investigate this, we studied the association between prostate cancer and smok... | BeFree | 16614120 | Detail |
0.003 | Malignant tumor of cervix | (2) rs1048943 (CYP1A1 A4889G) showed the strongest association with cervical can... | BeFree | 25928231 | Detail |
0.044 | Carcinoma of lung | CYP1A1 Ile462Val polymorphism and susceptibility to lung cancer: a meta-analysis... | BeFree | 22025136 | Detail |
0.124 | Malignant neoplasm of lung | Theses results suggest that the CYP1A1 Ile462Val polymorphism is associated with... | BeFree | 17980933 | Detail |
<0.001 | Oral Cavity Carcinoma | Cytochrome P450 1A1 Ile462Val polymorphism and oral carcinoma risk: an updated m... | BeFree | 22847262 | Detail |
0.017 | Malignant neoplasm of ovary | CYP1A1 Ile462Val is a risk factor for ovarian cancer development. | BeFree | 22277800 | Detail |
0.022 | breast carcinoma | We examined the potential association of breast cancer risk in Mexican women wit... | BeFree | 23000097 | Detail |
0.087 | Malignant neoplasm of prostate | To investigate this, we studied the association between prostate cancer and smok... | BeFree | 16614120 | Detail |
0.003 | Carcinoma of bladder | CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (n... | BeFree | 23886208 | Detail |
0.001 | Lymphoma, Large-Cell, Follicular | Our data provide evidence that the GSTP1 rs1695 and the CYP1A1 rs1048943 genotyp... | BeFree | 19899130 | Detail |
0.076 | squamous cell carcinoma | CYP1A1 Ile462Val polymorphism contributes to lung cancer susceptibility among lu... | BeFree | 22952673 | Detail |
0.012 | Carcinoma of lung | CYP1A1 rs4646903 (OR = 1.72, 95% CI = 1.25-2.38), rs1048943 (OR = 1.40, 95% CI =... | BeFree | 22525558 | Detail |
0.005 | Adenocarcinoma of lung (disorder) | The odds ratio (OR) of lung cancer for the variant CYP1A1 Ile(462)Val polymorphi... | BeFree | 12771031 | Detail |
0.004 | Uterine Fibroids | The genetic polymorphisms of IVS1+2329C>T and Val158Met loci in COMT, Ile462V... | BeFree | 24320736 | Detail |
0.124 | Malignant neoplasm of lung | CYP1A1 Ile462Val polymorphism contributes to lung cancer susceptibility among lu... | BeFree | 22952673 | Detail |
0.003 | Squamous cell carcinoma of lung | CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but ... | BeFree | 16195240 | Detail |
0.047 | Carcinoma of lung | In this Chinese cohort, with CYP1A1 valine allele frequency intermediate between... | BeFree | 11008920 | Detail |
0.001 | prostate carcinoma | To investigate this, we studied the association between prostate cancer and smok... | BeFree | 16614120 | Detail |
0.044 | Carcinoma of lung | Theses results suggest that the CYP1A1 Ile462Val polymorphism is associated with... | BeFree | 17980933 | Detail |
<0.001 | male infertility | Novel interactions were also observed between the MR of SEC and rs1042389 in CYP... | BeFree | 24488272 | Detail |
0.132 | male infertility | Novel interactions were also observed between the MR of SEC and rs1042389 in CYP... | BeFree | 24488272 | Detail |
0.002 | gallbladder carcinoma | These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and t... | BeFree | 17531965 | Detail |
Annotation
Annotations
Descrption | Source | Links |
---|---|---|
These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and the Pro allele of TP5... | DisGeNET | Detail |
The increased risk of breast cancer associated with E+P use was greater among women with at least on... | DisGeNET | Detail |
The increased risk of breast cancer associated with E+P use was greater among women with at least on... | DisGeNET | Detail |
The increased risk of breast cancer associated with E+P use was greater among women with at least on... | DisGeNET | Detail |
The increased risk of breast cancer associated with E+P use was greater among women with at least on... | DisGeNET | Detail |
All subjects were genotyped for 13 polymorphic variants in the genes of xenobiotics detoxification C... | DisGeNET | Detail |
All subjects were genotyped for 13 polymorphic variants in the genes of xenobiotics detoxification C... | DisGeNET | Detail |
All subjects were genotyped for 13 polymorphic variants in the genes of xenobiotics detoxification C... | DisGeNET | Detail |
All subjects were genotyped for 13 polymorphic variants in the genes of xenobiotics detoxification C... | DisGeNET | Detail |
All subjects were genotyped for 13 polymorphic variants in the genes of xenobiotics detoxification C... | DisGeNET | Detail |
However, further studies are still needed to accurately determine whether the CYP1A1 rs1048943 (A>... | DisGeNET | Detail |
We examined an Ile462Val polymorphism (CYP1A1*2 allele) of cytochrome P450 IA1 in a hospital-based c... | DisGeNET | Detail |
Furthermore, the combination of risk genotypes of CYP1B1 Leu432Val with CYP1A1 Ile462Val was associa... | DisGeNET | Detail |
CYP1A1 rs4646903 (OR = 1.72, 95% CI = 1.25-2.38), rs1048943 (OR = 1.40, 95% CI = 1.02-1.92), the GST... | DisGeNET | Detail |
Relationship between genetic polymorphism of CYP1A1 at codon 462 (Ile462Val) in colorectal cancer. | DisGeNET | Detail |
Our data provide evidence that the GSTP1 rs1695 and the CYP1A1 rs1048943 genotypes affect the risk o... | DisGeNET | Detail |
In this study, CYP1A1 (Ile462Val), CYP1B1(Asn453Ser), GST M1, GSTP1 exon 5 (Ile105Val) and exon 6(Al... | DisGeNET | Detail |
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... | DisGeNET | Detail |
(2) rs1048943 (CYP1A1 A4889G) showed the strongest association with cervical cancer in the allele ef... | DisGeNET | Detail |
CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell ca... | DisGeNET | Detail |
The genetic polymorphism of rs3087869 (IVS1+2329C>T) (OR 3.200, 95% CI 1.614-6.345) and rs4680 (V... | DisGeNET | Detail |
CYP1A1 rs4646903 (OR = 1.72, 95% CI = 1.25-2.38), rs1048943 (OR = 1.40, 95% CI = 1.02-1.92), the GST... | DisGeNET | Detail |
In this Chinese cohort, with CYP1A1 valine allele frequency intermediate between Japanese and Caucas... | DisGeNET | Detail |
CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (null) polymorphisms a... | DisGeNET | Detail |
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... | DisGeNET | Detail |
Furthermore, the combination of risk genotypes of CYP1B1 Leu432Val with CYP1A1 Ile462Val was associa... | DisGeNET | Detail |
The estimated head and neck cancer risk for the combination of either CYP1A1 Ile462Val or CYP1A1 Val... | DisGeNET | Detail |
CYP1A1 Ile462Val polymorphism and cervical cancer: evidence from a meta-analysis. | DisGeNET | Detail |
In this study, CYP1A1 (Ile462Val), CYP1B1(Asn453Ser), GST M1, GSTP1 exon 5 (Ile105Val) and exon 6(Al... | DisGeNET | Detail |
We concluded that the carriage of CYP1A1 Ile462Val AG and CYP1B1 Leu 432Val CC genotypes predict the... | DisGeNET | Detail |
CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (null) polymorphisms a... | DisGeNET | Detail |
CYP1A1 Ile462Val polymorphism and susceptibility to lung cancer: a meta-analysis based on 32 studies... | DisGeNET | Detail |
CYP1A1 I462V genetic polymorphism and lung cancer risk in a cohort of men in Shanghai, China. | DisGeNET | Detail |
In this study, CYP1A1 (Ile462Val), CYP1B1(Asn453Ser), GST M1, GSTP1 exon 5 (Ile105Val) and exon 6(Al... | DisGeNET | Detail |
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... | DisGeNET | Detail |
In this study, CYP1A1 (Ile462Val), CYP1B1(Asn453Ser), GST M1, GSTP1 exon 5 (Ile105Val) and exon 6(Al... | DisGeNET | Detail |
The CYP1A1 rs1048943 AG genotype and the combined AG/GG genotypes were associated with increased ris... | DisGeNET | Detail |
Cytochrome P450 1A1 Ile462Val polymorphism and oral carcinoma risk: an updated meta-analysis includi... | DisGeNET | Detail |
To investigate this, we studied the association between prostate cancer and smoking, as well as the ... | DisGeNET | Detail |
Furthermore, the combination of risk genotypes of CYP1B1 Leu432Val with CYP1A1 Ile462Val was associa... | DisGeNET | Detail |
To assess the effect of IL13 (-1112 C>T and Arg110Gln), GSTP1 (Ile105Val), and CYP1A1 (Ile462Val)... | DisGeNET | Detail |
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... | DisGeNET | Detail |
Relationship between genetic polymorphism of CYP1A1 at codon 462 (Ile462Val) in colorectal cancer. | DisGeNET | Detail |
Our study therefore suggests that the CYP1A1 Ile(462)Val variant allele might play a role in lung ca... | DisGeNET | Detail |
CYP1A1 Ile462Val is a risk factor for ovarian cancer development. | DisGeNET | Detail |
Theses results suggest that the CYP1A1 Ile462Val polymorphism is associated with a reduced risk of l... | DisGeNET | Detail |
Our results suggest that the I462V and Msp1 polymorphisms in CYP1A1 may be an additional susceptibil... | DisGeNET | Detail |
CYP1A1 Ile462Val polymorphism contributes to colorectal cancer risk: a meta-analysis. | DisGeNET | Detail |
CYP1A1 rs4646903 (OR = 1.72, 95% CI = 1.25-2.38), rs1048943 (OR = 1.40, 95% CI = 1.02-1.92), the GST... | DisGeNET | Detail |
CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (null) polymorphisms a... | DisGeNET | Detail |
In this study, we investigated the impact of the CYP1A1 Ile462Val polymorphism upon tumor risk and d... | DisGeNET | Detail |
To investigate this, we studied the association between prostate cancer and smoking, as well as the ... | DisGeNET | Detail |
Quantitative synthesis of the association between the cytochrome P450 1A1 Ile462Val polymorphism and... | DisGeNET | Detail |
CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (null) polymorphisms a... | DisGeNET | Detail |
CYP1A1 Ile462Val polymorphism as a risk factor in cervical cancer development in the Polish populati... | DisGeNET | Detail |
To assess the effect of IL13 (-1112 C>T and Arg110Gln), GSTP1 (Ile105Val), and CYP1A1 (Ile462Val)... | DisGeNET | Detail |
Our data provide evidence that the GSTP1 rs1695 and the CYP1A1 rs1048943 genotypes affect the risk o... | DisGeNET | Detail |
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... | DisGeNET | Detail |
CYP1A1 Ile462Val polymorphism contributes to lung cancer susceptibility among lung squamous carcinom... | DisGeNET | Detail |
We here carried out a population based case-control study of the CYP MspI (CYP1A1*1/M1) and Ile462Va... | DisGeNET | Detail |
Quantitative synthesis of the association between the cytochrome P450 1A1 Ile462Val polymorphism and... | DisGeNET | Detail |
CYP1A1 rs4646903 (OR = 1.72, 95% CI = 1.25-2.38), rs1048943 (OR = 1.40, 95% CI = 1.02-1.92), the GST... | DisGeNET | Detail |
We examined an Ile462Val polymorphism (CYP1A1*2 allele) of cytochrome P450 IA1 in a hospital-based c... | DisGeNET | Detail |
The polymorphic frequency of 10 genetic susceptibility genes and their association with lung cancer ... | DisGeNET | Detail |
To evaluate the roles of CYP1A1 polymorphisms [Ile 462Val and T 6235C (MspI)] and deletion of GSTM1 ... | DisGeNET | Detail |
CYP1A1 rs4646903 (OR = 1.72, 95% CI = 1.25-2.38), rs1048943 (OR = 1.40, 95% CI = 1.02-1.92), the GST... | DisGeNET | Detail |
The genetic polymorphism of rs3087869 (IVS1+2329C>T) (OR 3.200, 95% CI 1.614-6.345) and rs4680 (V... | DisGeNET | Detail |
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... | DisGeNET | Detail |
Association of CYP1A1 gene variants rs4646903 (T>C) and rs1048943 (A>G) with cervical cancer i... | DisGeNET | Detail |
The genetic polymorphisms of IVS1+2329C>T and Val158Met loci in COMT, Ile462Val and Gly45Asp loci... | DisGeNET | Detail |
We here carried out a population based case-control study of the CYP MspI (CYP1A1*1/M1) and Ile462Va... | DisGeNET | Detail |
The increased risk of brain tumors was evident for CYP1A1 rs2606345 (P = 0.0028; OR = 2.06; 95 % CI,... | DisGeNET | Detail |
The genetic polymorphisms of IVS1+2329C>T and Val158Met loci in COMT, Ile462Val and Gly45Asp loci... | DisGeNET | Detail |
Lack of association between the CYP1A1 Ile462Val polymorphism and endometrial cancer risk: a meta-an... | DisGeNET | Detail |
CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (null) polymorphisms a... | DisGeNET | Detail |
We concluded that the carriage of CYP1A1 Ile462Val AG and CYP1B1 Leu 432Val CC genotypes predict the... | DisGeNET | Detail |
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... | DisGeNET | Detail |
These results suggest that the genotype of CYP1A1 Ile462Val was associated with the increased risk o... | DisGeNET | Detail |
The CYP1A1 Ile462Val polymorphism and platinum resistance of epithelial ovarian neoplasms. | DisGeNET | Detail |
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... | DisGeNET | Detail |
To investigate this, we studied the association between prostate cancer and smoking, as well as the ... | DisGeNET | Detail |
CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (null) polymorphisms a... | DisGeNET | Detail |
We concluded that the carriage of CYP1A1 Ile462Val AG and CYP1B1 Leu 432Val CC genotypes predict the... | DisGeNET | Detail |
CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell ca... | DisGeNET | Detail |
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... | DisGeNET | Detail |
In Caucasians, those with the IIe/Val genotype at CYP1A1 Ile(462)Val locus were at decreased risk of... | DisGeNET | Detail |
Association between CYP1A1 Ile462Val variation and acute leukemia risk: meta-analyses including 2164... | DisGeNET | Detail |
Our data provide evidence that the GSTP1 rs1695 and the CYP1A1 rs1048943 genotypes affect the risk o... | DisGeNET | Detail |
Lack of association between the CYP1A1 Ile462Val polymorphism and endometrial cancer risk: a meta-an... | DisGeNET | Detail |
The estimated head and neck cancer risk for the combination of either CYP1A1 Ile462Val or CYP1A1 Val... | DisGeNET | Detail |
The CYP1A1 IVS1 + 606 (rs2606345) T allele was associated with gallbladder [odds ratio (OR) = 2.0, 9... | DisGeNET | Detail |
To evaluate the roles of CYP1A1 polymorphisms [Ile 462Val and T 6235C (MspI)] and deletion of GSTM1 ... | DisGeNET | Detail |
CYP1A1 Ile462Val polymorphism as a risk factor in cervical cancer development in the Polish populati... | DisGeNET | Detail |
In this study, CYP1A1 (Ile462Val), CYP1B1(Asn453Ser), GST M1, GSTP1 exon 5 (Ile105Val) and exon 6(Al... | DisGeNET | Detail |
CYP1A1 Ile462Val polymorphism and cervical cancer: evidence from a meta-analysis. | DisGeNET | Detail |
The genetic polymorphism of rs3087869 (IVS1+2329C>T) (OR 3.200, 95% CI 1.614-6.345) and rs4680 (V... | DisGeNET | Detail |
CYP1A1 I462V genetic polymorphism and lung cancer risk in a cohort of men in Shanghai, China. | DisGeNET | Detail |
These new data establish an association between the CYP1A1 Ile462Val polymorphism and the risk of de... | DisGeNET | Detail |
CYP1A1 Ile462Val polymorphism and colorectal cancer risk in Polish patients. | DisGeNET | Detail |
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... | DisGeNET | Detail |
CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell ca... | DisGeNET | Detail |
To investigate this, we studied the association between prostate cancer and smoking, as well as the ... | DisGeNET | Detail |
To evaluate the roles of CYP1A1 polymorphisms [Ile 462Val and T 6235C (MspI)] and deletion of GSTM1 ... | DisGeNET | Detail |
In Caucasians, those with the IIe/Val genotype at CYP1A1 Ile(462)Val locus were at decreased risk of... | DisGeNET | Detail |
Association of CYP1A1 gene variants rs4646903 (T>C) and rs1048943 (A>G) with cervical cancer i... | DisGeNET | Detail |
To investigate this, we studied the association between prostate cancer and smoking, as well as the ... | DisGeNET | Detail |
CYP1A1 Ile462Val polymorphism contributes to colorectal cancer risk: a meta-analysis. | DisGeNET | Detail |
CYP1A1 Ile462Val polymorphism and colorectal cancer risk in Polish patients. | DisGeNET | Detail |
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... | DisGeNET | Detail |
CYP1A1 Ile462Val polymorphism and the risk of non-small cell lung cancer in a Chinese population. | DisGeNET | Detail |
CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (null) polymorphisms a... | DisGeNET | Detail |
Lack of association between the CYP1A1 Ile462Val polymorphism and endometrial cancer risk: a meta-an... | DisGeNET | Detail |
The polymorphic frequency of 10 genetic susceptibility genes and their association with lung cancer ... | DisGeNET | Detail |
Lack of an association between CYP1A1 gene Ile462Val polymorphism and polycystic ovary syndrome in C... | DisGeNET | Detail |
In this study, we investigated the impact of the CYP1A1 Ile462Val polymorphism upon tumor risk and d... | DisGeNET | Detail |
To investigate this, we studied the association between prostate cancer and smoking, as well as the ... | DisGeNET | Detail |
(2) rs1048943 (CYP1A1 A4889G) showed the strongest association with cervical cancer in the allele ef... | DisGeNET | Detail |
CYP1A1 Ile462Val polymorphism and susceptibility to lung cancer: a meta-analysis based on 32 studies... | DisGeNET | Detail |
Theses results suggest that the CYP1A1 Ile462Val polymorphism is associated with a reduced risk of l... | DisGeNET | Detail |
Cytochrome P450 1A1 Ile462Val polymorphism and oral carcinoma risk: an updated meta-analysis includi... | DisGeNET | Detail |
CYP1A1 Ile462Val is a risk factor for ovarian cancer development. | DisGeNET | Detail |
We examined the potential association of breast cancer risk in Mexican women with the polymorphisms ... | DisGeNET | Detail |
To investigate this, we studied the association between prostate cancer and smoking, as well as the ... | DisGeNET | Detail |
CYP1A1 (Ile462Val), CYP1B1 (Ala119Ser and Val432Leu), GSTM1 (null), and GSTT1 (null) polymorphisms a... | DisGeNET | Detail |
Our data provide evidence that the GSTP1 rs1695 and the CYP1A1 rs1048943 genotypes affect the risk o... | DisGeNET | Detail |
CYP1A1 Ile462Val polymorphism contributes to lung cancer susceptibility among lung squamous carcinom... | DisGeNET | Detail |
CYP1A1 rs4646903 (OR = 1.72, 95% CI = 1.25-2.38), rs1048943 (OR = 1.40, 95% CI = 1.02-1.92), the GST... | DisGeNET | Detail |
The odds ratio (OR) of lung cancer for the variant CYP1A1 Ile(462)Val polymorphism (Ile/Val, Val/Val... | DisGeNET | Detail |
The genetic polymorphisms of IVS1+2329C>T and Val158Met loci in COMT, Ile462Val and Gly45Asp loci... | DisGeNET | Detail |
CYP1A1 Ile462Val polymorphism contributes to lung cancer susceptibility among lung squamous carcinom... | DisGeNET | Detail |
CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell ca... | DisGeNET | Detail |
In this Chinese cohort, with CYP1A1 valine allele frequency intermediate between Japanese and Caucas... | DisGeNET | Detail |
To investigate this, we studied the association between prostate cancer and smoking, as well as the ... | DisGeNET | Detail |
Theses results suggest that the CYP1A1 Ile462Val polymorphism is associated with a reduced risk of l... | DisGeNET | Detail |
Novel interactions were also observed between the MR of SEC and rs1042389 in CYP2B6, rs1048943 in CY... | DisGeNET | Detail |
Novel interactions were also observed between the MR of SEC and rs1042389 in CYP2B6, rs1048943 in CY... | DisGeNET | Detail |
These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and the Pro allele of TP5... | DisGeNET | Detail |
Overlapped Transcript Coordinates
Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
---|
Overlapped Transcript
Gene | Transcript ID | Chromosome | Start | Stop | Links |
---|
- Gene
- -
- dbSNP
- rs1048943 dbSNP
- Genome
- hg19
- Position
- chr15:75,012,985-75,012,985
- Variant Type
- snv
- Reference Allele
- T
- Alternative Allele
- A
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