chr2:162999392:> Detail (hg19)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr2:162,999,392-163,008,914 |
| hg38 | chr2:162,142,882-162,152,404 |
HGVS
| Type | Transcript | Protein |
|---|---|---|
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
Frequency
[No Data.]
Prediction
[No Data.]
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Links
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
[No Data.]
DisGeNET
| Score | Disease name | Description | Source | Pubmed | Links |
|---|---|---|---|---|---|
| <0.001 | Cardiomyopathy, Dilated | NA | BeFree | Detail | |
| <0.001 | Cardiovascular Diseases | NA | BeFree | Detail | |
| 0.120 | Catalepsy | NA | CTD_human | Detail | |
| 0.120 | colitis | NA | BeFree,CTD_human | Detail | |
| 0.120 | Colonic Neoplasms | NA | CTD_human | Detail | |
| 0.120 | Comatose | NA | CTD_human | Detail | |
| 0.120 | Constipation | NA | CTD_human | Detail | |
| <0.001 | Coronary Arteriosclerosis | NA | BeFree | Detail | |
| <0.001 | Coronary heart disease | NA | BeFree | Detail | |
| <0.001 | Crohn Disease | NA | BeFree | Detail | |
| 0.011 | Diabetes | We investigated whether oral administration of human commensal bacteria engineer... | BeFree | 25626737 | Detail |
| 0.011 | Diabetes | Of these, glucagon and GLP-1 have received the most attention because of importa... | BeFree | 25834231 | Detail |
| 0.016 | diabetes mellitus | Studies of the glucagon-like peptide 1 (GLP-1) receptor have been directed at id... | BeFree,GAD | 24687535 | Detail |
| 0.016 | diabetes mellitus | We investigated whether oral administration of human commensal bacteria engineer... | BeFree,GAD | 25626737 | Detail |
| 0.016 | diabetes mellitus | Of these, glucagon and GLP-1 have received the most attention because of importa... | BeFree,GAD | 25834231 | Detail |
| 0.080 | Diabetes Mellitus, Experimental | NA | RGD | Detail | |
| 0.003 | Diabetes Mellitus, Insulin-Dependent | We also detail evidence that animal models of autoimmune diabetes mimic both the... | BeFree | 25200302 | Detail |
| 0.154 | Diabetes Mellitus, Non-Insulin-Dependent | Due to such advantages, GLP-1-based therapeutics have been rapidly developed and... | BeFree,CTD_human,GAD | 24725840 | Detail |
| 0.154 | Diabetes Mellitus, Non-Insulin-Dependent | The immuno contents of glucagon-like peptide-1 and GIP decreased in T2DM jejunum... | BeFree,CTD_human,GAD | 24831459 | Detail |
| 0.154 | Diabetes Mellitus, Non-Insulin-Dependent | Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide... | BeFree,CTD_human,GAD | 25191754 | Detail |
| 0.154 | Diabetes Mellitus, Non-Insulin-Dependent | To determine the role of GLP-1 in improved glucose tolerance after surgery, we c... | BeFree,CTD_human,GAD | 25204975 | Detail |
| 0.154 | Diabetes Mellitus, Non-Insulin-Dependent | Hence, strategies that prevent GLP-1 degradation or activate the GLP-1 receptor ... | BeFree,CTD_human,GAD | 25412624 | Detail |
| 0.154 | Diabetes Mellitus, Non-Insulin-Dependent | We evaluated the insulinotropic properties of glucagon-like peptide-1 (GLP-1) an... | BeFree,CTD_human,GAD | 25748606 | Detail |
| 0.154 | Diabetes Mellitus, Non-Insulin-Dependent | Polymorphisms of GLP-1 receptor gene and response to GLP-1 analogue in patients ... | BeFree,CTD_human,GAD | 25785276 | Detail |
| <0.001 | Diabetic Nephropathy | NA | BeFree | Detail | |
| <0.001 | diarrhea | NA | BeFree | Detail | |
| <0.001 | fibrosarcoma | NA | BeFree | Detail | |
| 0.003 | food allergy | NA | LHGDN | Detail | |
| 0.001 | Glucagonoma | NA | BeFree | Detail | |
| 0.120 | Heart Diseases | NA | CTD_human | Detail | |
| 0.120 | Heart failure | NA | CTD_human | Detail | |
| <0.001 | Von Hippel-Lindau syndrome | NA | BeFree | Detail | |
| 0.127 | hyperglycemia | Chronic hyperglycaemia is associated with a dramatic reduction in insulin-positi... | BeFree,CTD_human | 25145789 | Detail |
| 0.127 | hyperglycemia | In morbid obesity, proximal intestine glucose absorption is accelerated and rela... | BeFree,CTD_human | 25423571 | Detail |
| 0.127 | hyperglycemia | We investigated whether oral administration of human commensal bacteria engineer... | BeFree,CTD_human | 25626737 | Detail |
| 0.127 | hyperglycemia | Antagonizing glucagon action represents an attractive therapeutic option for red... | BeFree,CTD_human | 26020795 | Detail |
| 0.127 | hyperglycemia | To investigate alterations in gene expression resulting from incubation with GLP... | BeFree,CTD_human | 26315270 | Detail |
| 0.122 | hyperinsulinism | In morbid obesity, proximal intestine glucose absorption is accelerated and rela... | BeFree,CTD_human | 25423571 | Detail |
| 0.120 | Hyperlipidemia | NA | CTD_human | Detail | |
| 0.120 | Hypertensive disease | NA | BeFree,CTD_human | Detail | |
| 0.005 | hypoglycemia | We therefore briefly review the contribution that autonomic activation, and symp... | BeFree | 25200302 | Detail |
| 0.005 | hypoglycemia | The counter-regulatory hormones glucagon, epinephrine, norepinephrine, growth ho... | BeFree | 25263215 | Detail |
| 0.005 | hypoglycemia | Electrophysiological and optogenetic techniques established that Glut2 (also kno... | BeFree | 25421524 | Detail |
| 0.120 | Hypotension | NA | CTD_human | Detail | |
| 0.120 | Hypothermia, natural | NA | CTD_human | Detail | |
| 0.001 | insulinoma | NA | BeFree | Detail | |
| <0.001 | Intestinal Diseases | NA | BeFree | Detail | |
| <0.001 | Intestinal Neoplasms | NA | BeFree | Detail | |
| 0.003 | irritable bowel syndrome | NA | BeFree,LHGDN | Detail | |
| <0.001 | liver cirrhosis | NA | BeFree | Detail | |
| <0.001 | Liver diseases | NA | BeFree | Detail | |
| <0.001 | multiple endocrine neoplasia type 1 | NA | BeFree | Detail | |
| <0.001 | multiple endocrine neoplasia type 2A | NA | BeFree | Detail | |
| <0.001 | meningioma | NA | BeFree | Detail | |
| <0.001 | Metabolic Diseases | NA | BeFree | Detail | |
| <0.001 | spinal muscular atrophy | NA | BeFree | Detail | |
| 0.003 | myocardial infarction | NA | LHGDN | Detail | |
| 0.003 | Neoplasm Metastasis | NA | BeFree,LHGDN | Detail | |
| <0.001 | neuroblastoma | NA | BeFree | Detail | |
| <0.001 | Nodule | NA | BeFree | Detail | |
| <0.001 | pheochromocytoma | NA | BeFree | Detail | |
| <0.001 | Pituitary Diseases | NA | BeFree | Detail | |
| <0.001 | polyps | NA | BeFree | Detail | |
| <0.001 | psoriasis | NA | BeFree | Detail | |
| 0.003 | short bowel syndrome | NA | BeFree,LHGDN | Detail | |
| 0.120 | Spasm | NA | CTD_human | Detail | |
| 0.120 | Stomach Diseases | NA | CTD_human | Detail | |
| <0.001 | subacute sclerosing panencephalitis | NA | BeFree | Detail | |
| <0.001 | substance dependence | Collectively, these data suggest that ghrelin and GLP-1 receptors may be novel t... | BeFree | 24958205 | Detail |
| 0.120 | Tachycardia | NA | CTD_human | Detail | |
| 0.120 | Sinus Tachycardia | NA | CTD_human | Detail | |
| 0.120 | Vascular Diseases | NA | CTD_human | Detail | |
| <0.001 | severe combined immunodeficiency | NA | BeFree | Detail | |
| <0.001 | gestational diabetes | The elevated GLP-1 levels in gestational diabetes women suggested some abnormali... | BeFree | 24639413 | Detail |
| <0.001 | Pancreatitis, Chronic | NA | BeFree | Detail | |
| <0.001 | acute myocardial infarction | Intracoronary infusion of encapsulated glucagon-like peptide-1-eluting mesenchym... | BeFree | 25294400 | Detail |
| <0.001 | Malnutrition | NA | BeFree | Detail | |
| <0.001 | Diabetes, Autoimmune | We also detail evidence that animal models of autoimmune diabetes mimic both the... | BeFree | 25200302 | Detail |
| <0.001 | hepatoblastoma | NA | BeFree | Detail | |
| <0.001 | Neuroendocrine Tumors | NA | BeFree | Detail | |
| <0.001 | pancreatic carcinoma | Based on the results, we suggest the potential use of GCC/GGC and GCG/CGC motifs... | BeFree | 25639356 | Detail |
| <0.001 | Gastrointestinal Stromal Tumors | NA | BeFree | Detail | |
| <0.001 | Dyslipidemias | NA | BeFree | Detail | |
| 0.003 | Muscular Dystrophy, Oculopharyngeal | NA | BeFree | Detail | |
| 0.006 | Impaired glucose tolerance | NA | BeFree,LHGDN | Detail | |
| <0.001 | Fasting Hypoglycemia | NA | BeFree | Detail | |
| <0.001 | Reactive hypoglycemia | NA | BeFree | Detail | |
| <0.001 | benign meningioma | NA | BeFree | Detail | |
| <0.001 | Chronic ulcer | NA | BeFree | Detail | |
| <0.001 | Corneal dystrophy, Lattice type 3 | NA | BeFree | Detail | |
| <0.001 | Maturity onset diabetes mellitus in young | NA | BeFree | Detail | |
| <0.001 | Diabetes mellitus autosomal dominant type II (disorder) | NA | BeFree | Detail | |
| <0.001 | Diabetes-deafness syndrome maternally transmitted (disorder) | NA | BeFree | Detail | |
| <0.001 | Malignant neoplasm of pancreas | Based on the results, we suggest the potential use of GCC/GGC and GCG/CGC motifs... | BeFree | 25639356 | Detail |
| <0.001 | Malignant neoplasm of prostate | NA | BeFree | Detail | |
| <0.001 | Non-alcoholic Fatty Liver Disease | NA | BeFree | Detail | |
| 0.120 | Hyperactive behavior | NA | CTD_human | Detail | |
| 0.120 | Bradycardia | NA | CTD_human | Detail | |
| <0.001 | Metabolic syndrome X | The role of glucagon-like peptide 1 (GLP-1) variants in metabolic syndrome (MS) ... | BeFree | 25376528 | Detail |
| <0.001 | Neurodegenerative Disorders | NA | BeFree | Detail | |
| 0.127 | hyperglycemia | The prevalent Glu23Lys polymorphism in the potassium inward rectifier 6.2 (KIR6.... | BeFree | 12196481 | Detail |
| <0.001 | prostate carcinoma | NA | BeFree | Detail | |
| <0.001 | Lung Diseases, Obstructive | NA | BeFree | Detail | |
| <0.001 | breast carcinoma | NA | BeFree | Detail | |
| <0.001 | colon carcinoma | NA | BeFree | Detail | |
| <0.001 | Central neuroblastoma | NA | BeFree | Detail | |
| <0.001 | Microalbuminuria | NA | BeFree | Detail | |
| <0.001 | Taste sweet | NA | BeFree | Detail | |
| <0.001 | Intraepithelial Neoplasia | NA | BeFree | Detail | |
| <0.001 | sarcoma | NA | BeFree | Detail | |
| <0.001 | Liver regeneration disorder | NA | BeFree | Detail | |
| <0.001 | pancreatic ductal adenocarcinoma | NA | BeFree | Detail | |
| <0.001 | drug dependence | Collectively, these data suggest that ghrelin and GLP-1 receptors may be novel t... | BeFree | 24958205 | Detail |
| 0.003 | Renal Insufficiency | NA | LHGDN | Detail | |
| <0.001 | Cirrhosis | NA | BeFree | Detail | |
| <0.001 | oculopharyngodistal myopathy | NA | BeFree | Detail | |
| <0.001 | Bietti crystalline corneoretinal dystrophy | NA | BeFree | Detail | |
| 0.120 | Aberrant Crypt Foci | NA | CTD_human | Detail | |
| <0.001 | coronary artery disease | NA | BeFree | Detail | |
| <0.001 | liver carcinoma | However, the ACA and GCG haplotypes in the IL-17 gene might be a risk factor and... | BeFree | 25429834 | Detail |
| <0.001 | Nonalcoholic Steatohepatitis | NA | BeFree | Detail | |
| <0.001 | Insulin resistance syndrome | NA | BeFree | Detail | |
| 0.003 | adenocarcinoma | NA | LHGDN | Detail | |
| 0.003 | anorexia nervosa | NA | LHGDN | Detail | |
| <0.001 | arteriosclerosis | A glucagon-like peptide-1 analog liraglutide suppresses macrophage foam cell for... | BeFree | 24418070 | Detail |
| 0.003 | atherosclerosis | A glucagon-like peptide-1 analog liraglutide suppresses macrophage foam cell for... | BeFree,GAD | 24418070 | Detail |
| <0.001 | azoospermia | NA | BeFree | Detail | |
| <0.001 | Malignant neoplasm of breast | NA | BeFree | Detail | |
| <0.001 | Malignant tumor of colon | NA | BeFree | Detail | |
| <0.001 | Malignant neoplasm of larynx | Haplotype analysis indicated that CCA (odds ratio [OR], 5.707; 95% confidence in... | BeFree | 24956286 | Detail |
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| We investigated whether oral administration of human commensal bacteria engineered to secrete GLP-1(... | DisGeNET | Detail |
| Of these, glucagon and GLP-1 have received the most attention because of important roles in glucose ... | DisGeNET | Detail |
| Studies of the glucagon-like peptide 1 (GLP-1) receptor have been directed at identifying polymorphi... | DisGeNET | Detail |
| We investigated whether oral administration of human commensal bacteria engineered to secrete GLP-1(... | DisGeNET | Detail |
| Of these, glucagon and GLP-1 have received the most attention because of important roles in glucose ... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| We also detail evidence that animal models of autoimmune diabetes mimic both the early loss of islet... | DisGeNET | Detail |
| Due to such advantages, GLP-1-based therapeutics have been rapidly developed and used clinically for... | DisGeNET | Detail |
| The immuno contents of glucagon-like peptide-1 and GIP decreased in T2DM jejunum, but incubation wit... | DisGeNET | Detail |
| Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are important... | DisGeNET | Detail |
| To determine the role of GLP-1 in improved glucose tolerance after surgery, we compared glucose and ... | DisGeNET | Detail |
| Hence, strategies that prevent GLP-1 degradation or activate the GLP-1 receptor are used to treat pa... | DisGeNET | Detail |
| We evaluated the insulinotropic properties of glucagon-like peptide-1 (GLP-1) and glucose-dependent ... | DisGeNET | Detail |
| Polymorphisms of GLP-1 receptor gene and response to GLP-1 analogue in patients with poorly controll... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Chronic hyperglycaemia is associated with a dramatic reduction in insulin-positive cells and an incr... | DisGeNET | Detail |
| In morbid obesity, proximal intestine glucose absorption is accelerated and related to increased SGL... | DisGeNET | Detail |
| We investigated whether oral administration of human commensal bacteria engineered to secrete GLP-1(... | DisGeNET | Detail |
| Antagonizing glucagon action represents an attractive therapeutic option for reducing hepatic glucos... | DisGeNET | Detail |
| To investigate alterations in gene expression resulting from incubation with GLP-1 (7-36) or hypergl... | DisGeNET | Detail |
| In morbid obesity, proximal intestine glucose absorption is accelerated and related to increased SGL... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| We therefore briefly review the contribution that autonomic activation, and sympathetic neural activ... | DisGeNET | Detail |
| The counter-regulatory hormones glucagon, epinephrine, norepinephrine, growth hormone and cortisol w... | DisGeNET | Detail |
| Electrophysiological and optogenetic techniques established that Glut2 (also known as Slc2a2)-expres... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Collectively, these data suggest that ghrelin and GLP-1 receptors may be novel targets for developme... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The elevated GLP-1 levels in gestational diabetes women suggested some abnormality in insulin secret... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Intracoronary infusion of encapsulated glucagon-like peptide-1-eluting mesenchymal stem cells preser... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| We also detail evidence that animal models of autoimmune diabetes mimic both the early loss of islet... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Based on the results, we suggest the potential use of GCC/GGC and GCG/CGC motifs as biomarkers in PC... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Based on the results, we suggest the potential use of GCC/GGC and GCG/CGC motifs as biomarkers in PC... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The role of glucagon-like peptide 1 (GLP-1) variants in metabolic syndrome (MS) and its components r... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| The prevalent Glu23Lys polymorphism in the potassium inward rectifier 6.2 (KIR6.2) gene is associate... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Collectively, these data suggest that ghrelin and GLP-1 receptors may be novel targets for developme... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| However, the ACA and GCG haplotypes in the IL-17 gene might be a risk factor and a protective marker... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| A glucagon-like peptide-1 analog liraglutide suppresses macrophage foam cell formation and atheroscl... | DisGeNET | Detail |
| A glucagon-like peptide-1 analog liraglutide suppresses macrophage foam cell formation and atheroscl... | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| NA | DisGeNET | Detail |
| Haplotype analysis indicated that CCA (odds ratio [OR], 5.707; 95% confidence interval [CI], 3.277-9... | DisGeNET | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- -
- dbSNP
- rs386597997 dbSNP
- Genome
- hg19
- Position
- chr2:162,999,392-163,008,914
- Variant Type
- snv
Genome browser